Beyond the Scope

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Single-center COVID-19 remote sign out experience, featuring medical student correspondent Harrison Dai Sep 27, 2021

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Beyond the Scope returns as David and Giovanni discuss a publication from Archives of Pathology and Laboratory Medicine: "Digital Pathology Initiatives and Experience of a Large Academic Institution During the Coronavirus Disease 2019 (COVID-19) Pandemic". Topics include process to establish a 100% digital workflow, the remote validation process, and how the workflow was also useful for research and education. (24:49) Then, Harrison Dai (MS2, Eastern Virginia University) joins the show in a new segment sharing his experience as a medical student during the pandemic, in addition to the medical student perspective on digital pathology.
Reference paper:
https://meridian.allenpress.com/aplm/article/145/9/1051/464723/Digital-Pathology-Initiatives-and-Experience-of-a
DPA links:
https://digitalpathologyassociation.org/
https://dpa-dapa.com/login

A forum to engage with the hosts and other listeners has been launched on the DPA website www.digitalpathologyassociation.org. DPA members may login to the DPA Collaborate hub (under the Resources tab) and join the Beyond The Scope community. All listeners are encouraged to use this forum to suggest future topics and guests, submit questions and corrections, and provide general feedback.

Raj Singh, MD | Northwell & Matthew Hannah, MD | MSKCC Aug 18, 2021

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Raj and Matt join Beyond the Scope to discuss the the Digital Anatomic Pathology Academy, hosted on PathPresenter - a primarily open source cloud based viewing platform for digital slides. DAPA is used as an educational, clinical, and publication tool. DPA members can access DAPA for free to make use of the numerous educational modules (dpa-dapa.com).
NOTE: this episode utilizes video for platform tutorials. Please visit https://digitalpathologyassociation.org/dpa-podcast-beyond-the-scope for the video version.

2:48 Guest intro
7:21 Introduction to the cloud based viewing and educational platform
8:47 Tutorial for navigating the platform
17:20 DAPA educational module features and demonstration
20:45 DAPA use cases; including an interactive way to study for boards
26:00 How DPA members and other can access the platform
27:50 Open source platform vs. licensed version for private data
30:10 MSKCC experience using the platform as an education portal and conference tool
33:00 Long term clinical goals of the platform
37:55 Utilizing the platform in underserved areas
39:23 Utilizing the platform for publications and E-books

Marilyn M. Bui, MD, PhD, FCAP | Moffitt Cancer Center Jul 15, 2021

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Marilyn M. Bui, MD, PhD, FCAP is a senior member in the Department of Pathology at Moffitt Cancer Center where she serves as the scientific director of the Analytic Microscopy Core. She has previously served as president of the DPA and currently chairs many committees for CAP and DPA. Dr. Bui joins Beyond the Scope to discuss her work toward digital pathology adoption and building a connected network of pathologists.

1:58 Introduction and what it means to be a pathologist in the digital age
6:03 Evolution of pathology toward the digital era
10:18 How experience as a molecular biology researcher led to a career focused on DP/AI
14:25 Building relationships through the DPA and how to get involved
18:24 Highlights throughout the years of DPA leadership
22:34 Global digital pathology collaborations
24:23 DAPA - a cloud based platform for DP education
31:05 Using social media to promote DP adoption and education
32:47 Digital health initiatives at Moffitt Cancer Center
36:33 Current research projects in DP/AI
41:55 The future of pathology - how to improve the workforce,promote a healthy lifestyle, and decrease the workload

Chen Sagiv, PhD, Co-founder & CEO of DeePathology Jun 21, 2021

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Chen Sagiv is an entrepreneur and computer scientist. She joins Beyond the Scope to discuss her story as a co-founder of DeePathology, a start-up providing AI tools for pathologists, as well as the challenges and excitement surrounding innovation in the digital pathology industry.

3:01 Introduction
7:29 Early applications of computer science in healthcare and why deep learning/AI methods are mandatory knowledge for modern computer scientists
11:15 The importance of cross disciplinary work between engineers, pathologists, and computer scientists
18:15 Story behind DeePathology and how the start-up helps pathologists use and understand AI tools
25:47 The perceived "black box" of AI vs. DIY AI platforms
31:50 Building AI algorithms from scratch
37:19 Advice for innovators in the pathology space

David Clunie, MD | DICOM Standards Author Jun 01, 2021

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Dr. David Clunie is a radiologist, medical informaticist, DICOM open source software author and editor of the DICOM standard. He joins Beyond The Scope to discuss image format standards surrounding digital pathology adoption. For more information, please visit: https://www.dclunie.com/ .

3:00 Intro
4:15 Background on PACS and DICOM, and the importance to pathology
6:39 History of DICOM as the image standard for radiology
10:04 Why an image standard has yet to emerge for pathology
15:38 How pathology departments can work with IT departments to aid the digital transition
16:54 Clarifying misconceptions about PACS
21:52 Discussing all cost elements associated with digital pathology transition
27:43 Advice to pathologists regarding image archival standards long term
33:20 Collaborative efforts between pathology, radiology, and IT departments
37:22 Educating the pathology community on image standards and regulatory barriers
44:51 The role of enterprise IT in DP adoption

Raisa Glabman, MSPH, VMD | NIH NCI CBSTP Fellow May 17, 2021

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Raisa Glabman is a veterinary pathologist and a fellow in the NIH/NCI Comparative Biomedical Scientist Training Program (CBSTP). Raisa joins Beyond the Scope to discuss her research on immunotherapy and the tumor microenvironment, how researchers in her field are using DP/AI, and the current state of DP adoption in veterinary medicine.

2:28 Introduction
4:37 NCI CBSTP program
9:00 Why veterinary pathology is interested in DP/AI for clinical and research applications
12:45 What human and veterinary pathologists can learn from each other regarding DP adoption
16:30 DP applications in various veterinary pathology settings - industrial labs, academic centers, and small clinics
20:25 Raisa's research on immunotherapy and the tumor microenvironment
25:53 How Raisa is using DP/AI for her research
28:10 Doing research during the pandemic
29:43 Being an early adopter of DP/AI tools for this specific type of research
34:50 How DP will help researchers ask new scientific questions

George Green, PhD | Bristol Myers Squibb Apr 30, 2021

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George Green, Head of Pharmacodiagnostics at Bristol Meyers Squibb, joins Beyond the Scope to discuss the pharmaceutical industry's perspective on digital pathology and artificial intelligence. The conversation revolves around how digital pathology will see increased applications in the current era of precision medicine.

1:22 Introduction
4:15 The companion diagnostics revolution in pharma
9:54 Early applications of digital pathology in pharma
14:38 How the mindset of pathologists has evolved since the dawn of DP/AI
19:55 Pharma perspective on how DP/AI will drive the future of precision medicine
25:00 Increasing DP adoption in the pharma industry
28:40 Digital pathology bringing better patient care around the world

Esther Abels | Visiopharm; DPA President-Elect Apr 06, 2021

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Esther Abels, co-chair of the DPA Regulatory & Standards Task Force, has worked on the regulatory approval of digital pathology systems since the beginning. She joins Beyond The Scope to discuss her current role advancing the regulatory science of digital pathology and provides an update on the initiatives of the DPA Regulatory and Standards Task Force. Esther also discusses the excitement surrounding digital pathology for precision medicine.

2:21 Introduction
6:25 Early applications of digital pathology to the pharma industry
8:00 Process of validating and achieving FDA approval of the first slide scanners
10:00 How collaboration and teamwork help achieve regulatory approval
17:48 Current initiatives of the DPA Regulatory and Standars Task Force
21:40 510(k) exemption of digital pathology devices
25:00 Real world data initiative and is remote sign out permanent?
31:08 Using digital pathology for precision medicine

Dr. Talat Zehra, MBBS, FCPS | Jinnah Sindh Medical University,Karachi,Pakistan Mar 30, 2021

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Talat Zehra is a pathologist at Jinnah Sindh University in Karachi, Pakistan. Dr. Zehra joins Beyond The Scope to share how the scarcity of pathologists in Pakistan and many other regions of the world affect patient care. Dr. Zehra also discusses the advantages and challenges of bringing digital pathology to developing countries.

1:00 Introduction
3:30 Dr. Zehra's research with WSI in Pakistan
6:15 Pathology services in Pakistan and other developing countries
13:15 Pathology in rural areas of the world
14:33 Benefits of digital pathology in developing countries
17:42 Challenges of digital pathology adoption in developing countries
19:05 Ideas for vendors and other pathologists to help increase adoption in developing countries

Please visit other resources mentioned in this podcast:

https://digitalpathologyassociation.org/blog/digital-pathology-enabling-remote-operations-during-covid-19-pandemic-and-beyond-pathologist-perception-working-in-pakistan

https://healthcare-in-europe.com/en/news/digital-pathology-dawns-in-developing-countries.html

Liron Pantanowitz, MD | University of Michigan Mar 17, 2021

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Liron Pantanowitz is an early adopter and major driving force behind global digital pathology adoption. He currently serves as a Professor in the Department of Pathology at the University of Michigan and has authored hundreds of papers related to digital pathology. Dr. Pantanowitz joins David and Giovanni to discuss the past, present, and future of digital pathology. This podcast is a must-listen for all levels of digital pathology adopters.

5:45 Introduction and background leading to a career focused on digital pathology
8:38 Milestones of digital pathology adoption
12:10 Digital pathology applications and the business case
15:46 The effect of COVID-19 on digital pathology adoption
23:23 Global digital pathology adoption
29:00 Training the next generation of digital pathologists
41:04 What's next for digital pathology

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