BBC Inside Science

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African genomes sequenced; Space weather; sports head injuries Oct 31, 2019

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Since the human genome was first sequenced nearly 20 years ago, around a million people have had theirs decoded, giving us new insights into the links between genes, ancestry and disease. But most of the genomes studied have been in people of European descent. Now a decade-long collaboration between scientists in the UK and in Uganda has created the largest African genome dataset to date. Dr Deepti Gurdasani discusses her research with Gaia Vince.

After 7 years of orbiting the Earth and sending us important information about space weather, NASA’s Van Allen Probes are retiring. Professor Lucie Green from UCL explains how the sun can spit out superhot plasma and streams of high energy particles in our direction. We are mostly protected by the Earth’s magnetic field - but not always. The worst-case scenario is that the radiation could disrupt navigation satellites and bring down electrical power supplies. Professor Green will be keeping an eye on space weather with a new spacecraft.

Growing evidence shows that repeatedly getting your head knocked around during competitive sports can lead to long-term serious consequences. The head doesn’t necessarily need to be the target of the blow – a hard tackle can ricochet through your body giving your head a jolt. Roland Pease speaks with sports scientist Liz Williams of Swansea University about a new device to measure these impacts.

Presenter: Gaia Vince Producers: Jen Whyntie and Louisa Field

Organic farming emissions; Staring at seagulls; Salt and dementia Oct 24, 2019

Show notes

Switching to 100% organic food production in England and Wales would see an overall increase in greenhouse gas emissions. Although going fully organic would produce fewer direct emissions than conventional farming, researchers say it would limit food production. Making up the shortfall with imports from overseas would increase overall emissions. But is the sustainability of our food production about more than greenhouse gas emissions alone? Professor Dave Reay is Chair in Carbon Management & Education at the University of Edinburgh, and has recently acquired a smallholding in Scotland. He discusses the study and answer your questions about sustainable food and population growth.

Seagulls have become notorious food thieves in recent times as they move into towns to find new habitats and sustenance. Scientists at the University of Exeter have found that if you stare at a herring gull, it’s much less likely to steal your chips. Reporter Graihagh Jackson went to Falmouth to meet with researchers Madeleine Goumas and Neeltje Boogert to see the tactic in action.

More than 800,000 people in the UK live with dementia, which is an umbrella term for over 200 specific diagnoses that all involve some form of neurodegeneration. Epidemiological evidence has suggested that high dietary salt intake may somehow be linked to developing cognitive impairment. A study released this week shows a mechanism for how this might occur biologically in the brains of mice who were fed a high salt diet. Professor Carol Brayne is Director of the Cambridge Institute of Public Health at the University of Cambridge, and she explains how this new research fits into the field and our understanding of dementia’s causes.

Ebola model, Partula snails, Malaria origin Oct 17, 2019

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Zoonotic diseases are infections that transfer from animals to people, and include killers such as bubonic plague, malaria, ebola and a whole host of others. Trying to understand how diseases make the leap from animals to humans – so called spillover – and how outbreaks occur is a crucial part of preventing them. But outbreaks are complex and dynamic, with a huge number of factors playing a role: What animal is hosting the disease, the environment in which it lives, the changing climate, human presence and impact on the local area and many other factors. Kate Jones is professor of ecology and biodiversity at University College London, and has been tracking ebola in Africa. Her team has just published a new study that models how and when spillover might happen in the future.

On the lushly forest islands of French Polynesia, there lives a very special snail. Partula are around 100 species of tiny snails who give birth to live young and feed on decomposing plants. Each species is uniquely adapted to a particular ecological niche. But in 1967, the highly edible Giant African Land Snail was introduced to the islands as a source of food. They quickly became pests, and in response, the French Polynesian government then introduced carnivorous Rosy Wolf Snails - aka Euglandina rosea - to quell the spread of the introduced Giant Land snails. Reporter Naomi Clements-Brode picks up the story with scientist Ann Clarke, along with Dave Clarke and Paul Pearce-Kelly at ZSL London Zoo.

Finally this week, malaria is, as best we can account for it, the single greatest killer in human history. The vast majority of malaria is caused by a type of single celled protozoan called Plasmodium falciparum, carried by mosquitos. But according to new research published this week, it started out around fifty thousand years ago not in us, but as a gorilla disease, and in one particularly unlucky gorilla, two simultaneous infections prompted the mutation and rise of the plasmodium parasite that would go on to kill millions. Dr Gavin Wright from the Wellcome Sanger Institute in Hinxton lead the team behind this molecular archaeology.

Extinction Rebellion, UK net zero emissions and climate change; Nobel Prizes Oct 10, 2019

Show notes

Extinction Rebellion is in the news with its stated aim of civil disobedience and protest, and goal to compel governments around the world to act on the climate crisis. Meanwhile, the UK government this week announced that it was overruling its own Planning Inspectorate, by approving in principle new gas-fired turbines at the Drax power station in North Yorkshire. The Inspectors had advised that the new developments would undermine UK climate policies on carbon emissions. In the UK we are committed to reaching net zero carbon emissions by 2050, in order to comply with our ratification of the Paris agreement, which aims to limit global temperature rise to 1.5 degrees. So what are we to do? Are the government policies and commitments enough, and are we sticking to them? Adam Rutherford discusses these questions with Jim Skea, Professor of Sustainable Energy at Imperial College, London, and co-chair of the Working Group tackling reducing emissions of greenhouse gases, part of the Intergovernmental Panel on Climate Change.

This week has been the annual jamboree and drama of the Nobel Prizes: the announcements of the biggest gongs in science. The Physiology or Medicine Prize went to William Kaelin from Harvard University, Sir Peter Ratcliffe from the Crick Institute in London and Gregg Semenza from Johns Hopkins University for their work on how the body responds to changing oxygen levels. The Physics Prize went to James Peebles of Princeton for cosmological discoveries, and Michel Mayor and Didier Queloz, then at the University of Geneva, for the 1995 discovery of the first exoplanet, 51 Pegasi b. And the Chemistry Prize was awarded for the invention of something that we utterly rely on every day, the lithium battery. The winners are John Goodenough, University of Texas at Austin, Stanley Whittingham, State University of New York, and Akira Yoshino of the Asahi Kasei Corporation in Japan. These awards offer plenty to discuss, so Adam is joined by Lisa Kaltenegger, Director of Carl Sagan Institute & Associate Professor of Astronomy, Andrew Pontzen, Professor of Astrophysics at University College, London, and reporter and presenter Marnie Chesterton, who spent some time with chemistry laureate John Goodenough.

HIV protective gene paper retraction, Imaging ancient Herculaneum scrolls, Bill Bryson's The Body Oct 03, 2019

Show notes

In November 2018 news broke via YouTube that He Jiankui, then a professor at Southern University of Science and Technology in Shenzhen, China had created the world’s first gene-edited babies from two embryos. The edited gene was CCR5 delta 32 - a gene that conferred protection against HIV. Alongside the public, most of the scientific community were horrified. There was a spate of correspondence, not just on the ethics, but also on the science. One prominent paper was by Rasmus Nielsen and Xinzhu Wei’s of the University of California, Berkeley. They published a study in June 2019 in Nature Medicine that found an increased mortality rate in people with an HIV-preventing gene variant. It was another stick used to beat Jiankiu – had he put a gene in these babies that was not just not helpful, but actually harmful? However it now turns out that the study by Nielsen and Wei has a major flaw. In a series of tweets, Nielsen was notified of an error in the UK Biobank data and his analysis. Sean Harrison at the University of Bristol tried and failed to replicate the result using the UK Biobank data. He posted his findings on Twitter and communicated with Nielsen and Wei who have now requested a retraction. UCL's Helen O'Neill is intimately acquainted with the story and she chats to Adam Rutherford about the role of social media in the scientific process of this saga.

The Herculaneum Library is perhaps the most remarkable collection of texts from the Roman era. Discovered two centuries ago in the villa of Julius Caesar’s father in law, many of the papyrus scrolls bear the writings of the house philosopher, Philodemus. Others are thought to be the works of the philosophers and poets he admired. However, the big drawback is that the villa was buried in the eruption that engulfed Pompeii, and the heat from the volcanic ash turned them all to charcoal. To make life even more difficult, the ink the scribes used was also made of carbon – think black on black. However, now a team from the University of Kentucky are hoping to decipher the texts using X-rays, and have just scanned two complete scrolls, and some fragments at the Diamond Synchrotron in near Oxford.

When renowned author Bill Bryson decided to apply his unique eye for anecdote and trivia to the human body he thought he's start at the head and work down. But as he reveals to Adam, it's a lot more complicated and interconnected than that. His book "The Body - A Guide for Occupants" is an indispensable guide to the inner workings of ourselves.

Producer: Fiona Roberts

Oceans, ice and climate change; Neolithic baby bottles; Caroline Criado-Perez wins RS Book Prize Sep 26, 2019

Show notes

The Intergovernmental Panel on Climate Change's special report on the oceans and cryosphere makes pretty grim reading on the state of our seas and icy places. Ocean temperatures are rising, permafrost and sea ice are melting, sea levels are rising and marine life is either moving or suffering the effects of temperature changes and acidification. Dr Phil Williamson, research fellow at the University of East Anglia, worked on the report and he explains to Adam Rutherford how the watery and icy parts of the planet connect to the atmosphere and climate.

It's a good job the small, round, spouted clay vessels found in 3000 year old baby graves in Bavaria weren't washed up very well. Crusts of food deposits have shown that these early baby bottles were used to give infants milk from ruminants such as cows, goats and sheep. This discovery, and previous discoveries of even earlier spouted vessels in Europe, indicate that settling down from hunter-gathering to agriculture in prehistoric Iron and Bronze-Age people impacted all ages. Dr Julie Dunne, organic geochemist at the University of Bristol, thinks that this more settled lifestyle with domesticated animals and cereals to supplement a baby's diet, led to earlier weaning and maybe more babies.

Caroline Criado Perez’s ground-breaking gender bias exposé wins the 2019 Royal Society Science Book Prize. 'Invisible Women: Exposing Data Bias in a World Designed for Men' by writer, broadcaster and feminist campaigner Caroline Criado Perez, becomes the 32nd winner of the prestigious Royal Society Insight Investment Science Books Prize. Caroline explains to Adam how a range of case studies, stories and new research highlights ways in which women are ‘forgotten’ on a daily basis. From government policy and medical research to technology, media and workplaces, she exposes the lack of gender-specific data that has unintentionally created a world biased against women

Producer - Fiona Roberts

MOSAiC Arctic super-expedition, Likely extinction of the Bahama nuthatch, Tim Smedley's book on air pollution Sep 19, 2019

Show notes

On Friday, 20 September, a powerful icebreaker called The Polarstern will set sail from Tromsø, Norway, with the aim of getting stuck into the polar ice. The plan is for the ship to spend the next year drifting past the North Pole, and this should enable scientists to collect unprecedented data on the Arctic. The Polarstern is the ‘mothership’ of a substantial international collaboration called the Multidisciplinary drifting Observatory for the Study of Arctic Climate (or project MOSAiC). Scientists from over seventy research institutions across 19 different countries are involved, and a total of six hundred experts will be aboard throughout the expedition. They plan to construct a ‘research city’ around the vessel with different neighbourhoods, each focused on a particular scientific area including: ecosystem, bio-geo-chemistry, ocean, atmosphere and sea ice. Adam spoke to UCL’s Professor Julienne Stroeve, who will be aboard The Polarstern for two months during the Arctic winter, looking at the depth and density of snow in order to improve our understanding of the Arctic, and enhance our ability to predict effects of global climate change.

The residents of the Bahamas are still struggling to come to terms with the devastation of Hurricane Dorian (which hit 2 weeks ago) and also with the additional impact of Tropical Storm Humberto which reached the islands on Friday night, bringing more heavy rain and more strong winds. But the human population is resilient and they will eventually rebuild and resume their lives on the Caribbean islands. But for the Bahama nuthatch, it’s thought that Dorian was the final straw. The endemic bird, is (or was) one of the rarest birds in the western hemisphere, in fact it was already thought extinct (after the damage wrought by Hurricane Mathew in June 2016) until last year when Professor Diana Bell and her team of conservationists from the University of East Anglia rediscovered it. But now, after the hurricane it is feared lost forever, and it may not be the only irreversible ecological loss for the Bahamas.

Tim Smedley's book 'Cleaning the Air: The Beginning and End of Air Pollution' is shortlisted for the Royal Society's science book prize. Tim tells the full story of air pollution: what it is, which pollutants are harmful, and where they come from. It's scary stuff, but there is good news that air pollution can be avoided and drastically reduced with sensible measures.

Producer - Fiona Roberts

Model embryos from stem cells, Paul Steinhardt's book on impossible crystals, Mother Thames Sep 12, 2019

Show notes

One of the most fundamental developmental stages we humans go through is extremely poorly understood. The first few days of the embryo, once it's been implanted in the womb is incredibly hard to study. Yet it's the time when the majority of pregnancies fail. Professor Magdalena Zernika-Goetz at Cambridge University is a leader in the field of making 'model embryos' in both mice and humans. Model embryos until now have been grown in the lab from donated fertilised eggs, but these are hard to come by and governed by strict laws and ethical guidelines. Now researchers in the University of Michigan have used human pluripotent stem cell lines (originally isolated from embryos, but kept and nurtured as clumps of dividing cells in petri-dishes for many years) to make a model embryo that has shown signs of development and organisation in the crucial 7-10 day window. Magdalena and Gaia Vince discuss how helpful these will be to understanding crucial early stage pregnancies and as a tool to test drugs, treatments and disease processes. The ethical side of growing human embryos from stem cells is addressed by Stanford University ethicist Professor Hank Greely.

Physicist Paul Steinhardt has spent a great deal of his career trying to understand crystals with seemingly impossible five fold symmetries. Most of this was with pen and pencil in his Princeton laboratory. But in his Royal Society Science Book Prize shortlisted book, 'The Second Kind of Impossible', he documents his adventurous quest for these 'quasicrystals' in the wilds of Russia's Kamchatka Peninsular.

In 1957 the River Thames was so polluted it was declared ecologically dead. But since then The Zoological Society of London in partnership with over 30 conservation and research organisations have been working to improve the health of the River Thames and bring back the plethora of life and biodiversity. They are set to publish the first complete analysis of the river in over 60 years this Autumn. They're calling it 'Mother Thames' in recognition of the now nurturing nature of one of Britain's biggest rivers.

Presenter - Gaia Vince Producer - Fiona Roberts

Inventing GPS, Carbon nanotube computer, Steven Strogatz and Monty Lyman discuss calculus and skin Sep 05, 2019

Show notes

Global Positioning System, or GPS is perhaps the best known of the satellite navigation systems, helping us find our way every day. Back in the 1970's Bradford Parkinson and Hugo Fruehauf were two of the inventors who miniaturised atomic clocks and launched them in Earth orbit satellites. This was part of the US Department of Defense's plan to track ships and aircraft and guide targeted missiles. In the intervening years, Brad and Hugo had no idea just how far the civilian applications of GPS would go. Alongside Richard Schwartz and James Spilker, they have just been awarded the prestigious the Queen Elizabeth Prize for Engineering.

The age of silicon chip based computing could be coming to an end. Difficulties in shrinking silicon transistors, or switches, into ever smaller processors led researchers at MIT to search for alternative semiconducting materials to replace them. Cue carbon nanotubes, tubes of carbon atoms many tens of thousands of times narrower than a human hair. Electrical engineer Max Shulaker and his team have overcome spaghetti-like tangles of CNTs and varying levels of conductivity to create a 16bit processor. He says that rather than a straight forward replacement to silicon, the initial hope is that CNT chip technology can be added to existing silicon wafers.

Steven Strogatz and Monty Lyman have been shortlisted for the Royal Society Insight Investment Science Book Prize this year. In "Infinite Powers", Professor of applied maths at Cornell University, Steven Strogatz tells Adam Rutherford the story of calculus and why his book has a warning saying "this book is dangerous, it will make you love mathematics!" And in "The Remarkable Life of the Skin" Dr. Monty Lyman takes Claudia Hammond on an intimate journey across our surface. They discuss advances in skin treatments, new research on the importance of our diet and our skin and the vital role our largest organ plays in our lives.

Producer - Fiona Roberts Presenter - Gareth Mitchell

Amazon fires, Royal Society Book Prize shortlist announced, John Gribben on quantum physics Aug 29, 2019

Show notes

Satellite data has shown an 85% increase in the number of fires across Brazil this year. There are more than 2,500 fires active across the Amazon region. This represents the most active number of fires since 2010. The increase in fires has been attributed to deliberate deforestation and clearing for agriculture or mining. The new president of Brazil, Jair Bolsanaro, supports the commercialisation of the Amazon forest and this is said to have encouraged the wide scale burning. Professor of Earth System Science at the University of California Irvine, Jim Randerson and Luiz Aragão of Brazil’s National Institute of Space Research are just two scientists concerned about the destruction and carbon emissions from the extensive burning.

The 6 shortlisted books have been announced in the Royal Society Insight Investment Science Book Prize this year. Judges Professor Sir Nigel Shadbolt, a computer scientist and best-selling author Dorothy Koomson run through the list: Infinite Powers – Steven Strogatz The Remarkable Life of the Skin – Monty Lyman Clearing the Air – Tim Smedley Invisible Women – Caroline Criado Perez The Second Kind of Impossible – Paul Steinhardt Six Impossible Things – John Gribbin

Science writer and journalist John Gribben takes Gareth through the world of quantum physics when he discusses his book "Six Impossible Things - The Quanta of Solace and the Mysteries of the Subatomic World"

Producer - Fiona Roberts

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