The Inner Workings of Cells, Winter 2008

Class Overview Jan 07, 2008

Lecture 01: Kaplan discusses class mechanics, student questions and the central questions of cell biology.

Goals of Cell Biology Jan 09, 2008

Lecture 02: Goals of cell biologists and the overall course plan are discussed and students introduced to the question of how to study cells.

Antibodies Jan 11, 2008

Lecture 03: This class reviews what characteristics a gene needs to be "necessary and sufficient." A discussion of antibodies and their application to various techniques of cell biologists.

Subcellular Fractionation Jan 14, 2008

Lecture 04: How to use subcellular fractionation and other techniques to study complex cellular processes and molecules.

Cell Membranes Jan 16, 2008

Lecture 05: This class wraps up of tools to study complex cellular behavior (including microscopy), and introduces membrane proteins.

Membrane Reactions Jan 18, 2008

Lecture 06: This is a continued discussion of cellular membranes and their various functions in biochemical reactions.

Membrane Proteins Jan 23, 2008

Lecture 07: Kaplan discusses the various classes of membrane proteins and movement of molecules across the membrane.

Secretory Pathway Jan 25, 2008

Lecture 08: Kaplan talks about how various proteins are directed to certain areas within the cell and to the plasma membrane.

Protein Movement Jan 28, 2008

Lecture 09: Kaplan discusses the secretory pathway, with emphasis on protein targeting and translocation.

Protein Movement Jan 30, 2008

Lecture 10: In this continued discussion on protein translocation, Kaplan gives emphasis to glycosylation and the Scavenger pathway.

ER Reactions Feb 01, 2008

Lecture 11: Kaplan reviews glycosylation and gives an in-depth look at the work done to understand protein translocation and examples of protein trafficking.

Vesicular Transport Feb 04, 2008

Lecture 12: Kaplan gives an in-depth discussion of in-vitro coupled translation and translocation.

Review of Protein Trafficking Feb 08, 2008

Lecture 14: The professor wraps up protein trafficking and non-secretory transport.

Review for Midterm 1 Feb 10, 2008

Review for Midterm 1: This class covers cell biology techniques, cell compartmentalization, cell membranes, the secretory pathway and protein trafficking.

Cell Movement Feb 13, 2008

Lecture 15: Kaplan discusses how cytoskeletal elements of a cell are involved in cell movement, such as actin.

Filament Dynamics Feb 15, 2008

Lecture 16: Kaplan continues talking about actin, how it can lead to cell motility, as well as how it and other filament dynamics are regulated within the cell.

Intermediate Filaments Feb 20, 2008

Lecture 17: This class covers actin polymerization, and an introduction to other parts of the cytoskeleton, such as the intermediate filaments.

Intermediate Filaments Feb 22, 2008

Lecture 18: In a continued discussion of intermediate filaments, Kaplan talks about their relation to other cytoskeletal filaments and microtubule dynamics.

Microtubules Feb 25, 2008

Lecture 19: In this class, microtubule dynamics and stability and how these aspects of microtubules are controlled to produce energy and force for processes such as mitosis.

Microtubles and Cell Motility Feb 27, 2008

Lecture 20: Kaplan wraps up of the cytoskeleton, relation of microtubles to cell motility, introduction to cell division.

Cell Division Feb 29, 2008

Lecture 21: The stages of the cell cycle, the regulatory cycle, and biochemical switches involved in these two cycles are covered.

Regulation of Cell Division Mar 03, 2008

Lecture 22: This is a continued discussion of the regulation of cell division -- how mitosis is coordinated within the cell.

Review for Midterm 2 Mar 04, 2008

Review for Midterm 2: This covers protein trafficking, the cytoskeleton and cell division.

Cell Division Mar 07, 2008

Lecture 24: Students learn more about cell division, and introduction to cell checkpoints along the regulatory cycle.

Cell Signaling Mar 10, 2008

Lecture 25: This class is a wrap-up of cell division and checkpoints in the regulatory cycle, and introduction to how cells interpret various biochemical signals.

Signal Transduction Mar 12, 2008

Lecture 26: Kaplan talks about properties of signaling modules and different kinds of membrane receptors that interpret signals from outside the cell.

Signal Transduction Mar 14, 2008

Lecture 27: Kaplan continues his discussion of signal transduction, the role of signals in cell migration, and the ability of cells to see which direction to move.

Cell Signaling & Cancer Cells Mar 17, 2008

Lecture 28: The instructor reviews some major pathways dealing with signal transduction and an application of principles learned to cancerous cells.

Review for Final Exam Mar 21, 2008

Review for Final Exam: This class covers all topics discussed in the course, with an emphasis on cell signaling.