unPAUSED with Dr. Mary Claire Haver

Latest Episodes:

Female Libido in Menopause: Desire Loss, Biology & Solutions with Cindy Eckert Feb 10, 2026

Show notes

This week on unPaused, Dr. Mary Claire Haver sits down with Cindy Eckert, founder and CEO of Sprout Pharmaceuticals and creator of Addyi, the first FDA approved treatment for low libido in women. Cindy is a pharmaceutical entrepreneur who began her career at Merck before founding her first company in 2007, focusing on undermarketed FDA approved products. After successfully building and selling a male sexual health company, she became the only woman running a sexual health company and witnessed firsthand the stark contrast between how medicine treats male versus female sexual dysfunction. Her journey to bring Addyi to market became a cultural battle about whether women's sexual desire matters, leading to two FDA rejections, public hearings, and ultimately a historic approval in 2015 after a six year fight.

In this conversation, Dr. Haver and Cindy explore how Addyi works differently from Viagra, targeting brain chemistry and desire rather than blood flow and arousal. Cindy explains that Addyi is a mood drug originally developed for depression that showed an unexpected effect on female libido during clinical trials. The medication works on neurotransmitters in the brain, building over approximately eight weeks to restore spontaneous thoughts, fantasies, and desire in women with hypoactive sexual desire disorder or HSDD. She walks through the massive clinical trial requirements, including 13,000 patients compared to Viagra's 4,000, and the three things they had to prove with statistical significance versus placebo: increased interest in sex, more satisfying sexual experiences, and decreased distress from the condition.

ADDYI, flibanserin, is for women <65 with low sexual desire disorder who have not had problems with low sexual desire in the past, and who have low sexual desire that is troubling to them no matter the type of sexual activity, situation, or sexual partner. The low sexual desire is not due to a medical or mental health problem, problems in the relationship or medicine or other drug use. ADDYI is not for men or to enhance sexual performance.

Your risk of severe low blood pressure and fainting is increased if you drink 1-2 standard alcoholic drinks close in time to your ADDYI dose. Wait at least 2 hours after one to two drinks before taking ADDYI at bedtime and skip your dose if you drink three or more drinks that evening. If you take certain prescription, OTC or herbal medications, or have liver problems, the risk of low blood pressure and fainting increases and you should not take ADDYI. Do not take if you are allergic to any of ADDYI’s ingredients. Sometimes serious sleepiness can occur. Common side effects include dizziness, nausea, tiredness, difficulty falling asleep or staying asleep and dry mouth. See PI and Boxed Warning at addyi.com/pi
Guest links:

Cindy Eckert
Cindy Eckert (Instagram)

Recommended Books:

“Mars and Venus in the Bedroom: A Guide to Lasting Romance and Passion,” by John Gray

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

Understanding Your Brain Through Perimenopause and Menopause with Dr. Louisa Nicola Feb 03, 2026

Show notes

Menopause, Hormones and Women’s Sexual Health with Dr. Rachel Rubin Jan 27, 2026

Show notes

In this episode Dr. Mary Claire Haver is joined by Dr. Rachel Rubin, a board-certified urologist and nationally recognized expert in sexual medicine, fellowship trained in both female and male sexual health. As assistant clinical professor of urology at Georgetown University and former education chair of the International Society for the Study of Women's Sexual Health, she brings unique insight into the stark disparities in how sexual dysfunction is treated across genders. Dr. Rubin founded the Sexual Medicine Research Team, and her advocacy work has been instrumental in changing FDA labeling on hormone therapy and advancing the American Urological Association Guidelines on genital urinary syndrome of menopause.

During the conversation, Dr. Haver and Dr. Rubin explore the intersection of menopause, hormones and women's sexual health, revealing why most doctors, including OB-GYNs, receive virtually no training in sexual health despite sexual dysfunction affecting millions of women. Dr. Rubin explains how men's sexual health benefits from 27 fellowship programs while women's sexual health has only three, and why erectile dysfunction research receives billions while female orgasm research gets nothing from the NIH. She breaks down the complete anatomy of the clitoris that most medical professionals never learned, explaining why understanding this matters for surgical outcomes, pleasure, and treating conditions like vulvar vestibule pain that affects penetration, tampon use, and pelvic exams. Dr. Rubin discusses how the vulvar vestibule, the hormone sensitive tissue surrounding the urethra, becomes a source of pain for many women during perimenopause, on birth control pills, or postpartum due to low estrogen and testosterone.

Guest links:

Dr. Rachel Rubin (Instagram)

Dr. Rachel Rubin (YouTube)

Dr. Rachel Rubin (Website)

Dr. Rachel Rubin (LinkedIn)

Dr. Rachel Rubin (Facebook)

Dr. Rachel Rubin (X)

Books

“Vagina Obscura: An Anatomical Voyage Hardcover,” by Rachel E. Gross

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

⁠"The New Menopause"⁠ by Dr. Mary Claire Haver

Articles

Sexual function after hysterectomy according to surgical indication: a prospective cohort study (Sexual Health)

The ...

Strong Bones, Strong Body, Stronger Second Half with Dr Jocelyn Wittstein - Part 2 Jan 22, 2026

Show notes

In this continuation of their conversation, Dr. Jocelyn Wittstein and Dr. Mary Claire Haver shift from understanding why menopause affects bones and joints to what actually works for building stronger bones and preventing fractures. If you've been told your bone density is declining, or you're worried about falls and fractures, this episode delivers the practical protocols you need.

Dr. Wittstein is a practicing orthopedic surgeon, researcher, and associate professor at Duke University specializing in sports medicine and the female athlete across the lifespan. She's also a former collegiate gymnast and mother of five. Her research focuses on frozen shoulder, ACL injuries in female athletes, and the musculoskeletal syndrome of menopause. As president of the Forum for Women in Sports Medicine, Dr. Wittstein is changing how we understand the intersection of hormones, movement, and independence in women's bodies.

They tackle the questions women ask most. How much exercise is enough? What types build bone? Is jumping necessary? They discuss the LIFT More trial and EFOPS trial, research showing women in structured exercise programs had fifty percent reduction in fracture risk, even as bone density eventually declined. This reveals something crucial: preventing fractures goes beyond bone density numbers alone.

Guest links:

Jocelyn Ross Wittstein, MD (Duke Health)

Jocelyn Wittstein, MD (Instagram)

Duke Female Athlete Program

Milken Institute Women’s Health Initiative

Books:
“The Complete Bone and Joint Health Plan: Help Prevent and Treat Osteoporosis and Arthritis,” by Dr. Jocelyn Wittstein and Sydney Nitzkorski, MS, RD

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

⁠"The New Menopause"⁠ by Dr. Mary Claire Haver

Menopause, Frozen Shoulder and the Joint Pain Wake Up Call with Dr. Jocelyn Wittstein - Part 1 Jan 20, 2026

Show notes

If you've ever struggled to put on a bra, reach behind your back, or lift your arm without searing pain in your shoulder, you're not alone. Frozen shoulder strikes women in midlife at alarming rates, yet for decades, medicine dismissed it as a mystery condition with no known cause. Orthopedic surgeon Dr. Jocelyn Wittstein saw what others missed: her patients with frozen shoulder were almost all women between forty and sixty, experiencing hot flashes, night sweats, and other symptoms of perimenopause and menopause. What she discovered is changing how we understand the impact of declining estrogen on women's joints, bones, and muscles.

Dr. Wittstein is a practicing orthopedic surgeon, researcher, and associate professor at Duke University, specializing in sports medicine and the female athlete across the lifespan. She's also a former collegiate gymnast and mother of five. Her research focuses on frozen shoulder, ACL injuries in female athletes, and the musculoskeletal syndrome of menopause. As president of the Forum for Women in Sports Medicine, Dr. Wittstein is changing how we understand the intersection of hormones, movement, and independence in women's bodies.

In this conversation, Dr. Mary Claire Haver and Dr. Wittstein explore how declining estrogen during perimenopause and menopause impacts joints, bones, muscles, and connective tissue. They discuss why frozen shoulder disproportionately affects women in midlife, with some Asian cultures having their own term for it that translates to fifty year shoulder. Dr. Wittstein explains the critical window for treatment, why early intervention can be transformative, and how hormone replacement therapy may prevent it, with preliminary data suggesting women using systemic estradiol have half the risk of developing frozen shoulder. She shares why physical therapy during the inflammatory phase can worsen it and how to recognize the early warning signs.

Guest links:

Jocelyn Ross Wittstein, MD (Duke Health)

Jocelyn Wittstein, MD (Instagram)

Duke Female Athlete Program

Milken Institute Women’s Health Initiative

Books
“The Complete Bone and Joint Health Plan: Help Prevent and Treat Osteoporosis and Arthritis,” by Dr. Jocelyn Wittstein and Sydney Nitzkorski, MS, RD

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

⁠"The New Menopause"⁠ by Dr. Mary Claire Haver

For full show notes, please click here.

Sally Wainwright on Riot Women, Identity Theft of Menopause, and Writing Real Female Characters Jan 17, 2026

Show notes

Award-winning British television creator Sally Wainwright joins Dr. Mary Claire Haver to discuss her groundbreaking new BBC series Riot Women, a drama about five midlife women who form a punk rock band while navigating menopause, aging parents, and the complexities of life after 50. Sally, the creative force behind acclaimed series including Happy Valley, Gentlemen Jack, and Last Tango in Halifax, shares how her own experience with perimenopause and menopause inspired the show and why she calls this life stage "identity theft."

The conversation explores Sally's journey from bus driver to one of British television's most celebrated showrunners, her commitment to portraying authentic female characters who carry grief, desire, sexuality, rage, and resilience in bodies that reflect actual lived experience, and how brain fog, joylessness, and depression led her to finally try hormone replacement therapy after initially believing outdated myths about breast cancer risk, and how that decision transformed her wellbeing.

Dr. Haver and Sally discuss the critical importance of naming menopause symptoms, from the devastating loss of motivation and confidence that can accompany hormonal changes to the sandwich generation pressures of dementia care for aging parents while raising teenagers. The episode examines why female stories, particularly those featuring women over 50, face funding challenges in entertainment, how male writers have historically constructed female characters through the male gaze, and why Sally believes women are more heroic and emotionally articulate than men.

They explore the revolutionary aspects of Riot Women, including its honest portrayal of sexual health, libido changes, medical gaslighting, and the transformative power of HRT, rarely if ever depicted on screen with such nuance and optimism. Sally discusses audience response to the series, including an unprecedented volume of thank-you letters to the BBC from viewers who felt seen for the first time, men's surprising embrace of the show despite its focus on female experience, and a handful of critics who complained about the absence of "nice men" despite the show's ensemble of complex, flawed characters of all genders. This conversation offers validation for anyone navigating the physical and emotional challenges of perimenopause and menopause, inspiration for creative midlife reinvention, and hope that entertainment is finally beginning to tell the truth about women's lives with the honesty, ferocity, humor, tenderness, and rage they deserve.

Guest links:

Sally Wainwright (Instagram)

Sally Wainwright (IMDB)

Articles

Menopausal Hormone Therapy and the Breast: A Review of Clinical Studies (Breast Care)

Anhedonia: A Concept Analysis (Archives of Psychiatric Nursing)

Other Resources

Primary Ovarian Insufficiency in Adolescents and Young Women (American College of Obstetricians and Gynecologists)

Riot Women (BBC)

Clips from Riot Women:

251105_RiotWomen_Ep1_Clip_Satisfaction_Bug.mp4

251105_RiotWom ...

From Hysteria to Medical Gaslighting and the Path Forward with Dr. Elizabeth Comen Jan 13, 2026

Show notes

Dr. Elizabeth Comen is a board certified oncologist at NYU Langone Health, co-director of the Mignoni Women's Health Collaborative, and author of the groundbreaking book “All In Her Head: The Truth and Lies Early Medicine Taught Us About Women’s Bodies and Why It Matters Today”. In this powerful conversation about medical gaslighting and women's healthcare, she and Dr. Mary Claire Haver trace the deep roots of medical misogyny and reveal why the healthcare system still dismisses women's symptoms today.

Dr. Comen shares the story of a breast cancer patient on her deathbed who, hours from death, apologized for sweating during a hug. It's a moment that captures what nearly every woman experiences in a doctor's office, the reflexive apology for being in a normal human body. Whether it's apologizing for leg hair in stirrups or hiding underwear during an exam, women have internalized tremendous shame about their bodies. Dr. Comen explains this isn't random. It's the legacy of a medical system built by men who dismissed women's pain and symptoms as hysteria, neurosis, or anxiety.

Through meticulous research into medical history, Dr. Comen reveals how this medical gaslighting became embedded in healthcare. She discusses William Osler, one of cardiology's founding fathers, who described women's chest pain as "neurotic angina" and wrote that "these women do not die." Yet heart disease is the number one killer of women. She explains how women are twice as likely to call an ambulance for their husband's heart attack than for themselves, and when they do seek help for chest pain, they're far more likely to be misdiagnosed with a panic attack instead of receiving proper cardiac care.

Dr. Haver and Dr. Comen discuss the systemic healthcare gaps across medical specialties: why 80% of autoimmune diseases affect women yet it's not considered a women's health field, why female specific surgeries are reimbursed at significantly lower rates than comparable male procedures, why Alzheimer's disease is twice as common in women but received almost no research funding, and how the legacy of dismissing women's sexual health continues in breast cancer and oncology care today. They explore bizarre historical medical fears like "bicycle face," the myth that women would become ugly and infertile from exercise, and how plastic surgery evolved to make women "marriage material" rather than serve their actual health needs.

Despite the sobering history of medical misogyny, this conversation ends with hope. Dr. Comen shares why she's optimistic about the cultural shift happening in women's healthcare now, the importance of women advocating for themselves in medical settings, and how the next generation doesn't have to wait for menopause to stop apologizing and start demanding better healthcare.

Guest links:

Dr. Elizabeth Comen

Dr. Elizabeth Comen (Instagram)

Dr. Elizabeth Comen (LinkedIn)

Dr. Elizabeth Comen, MD (NYU)

Books

“All in Her Head: The Truth and Lies Early Medicine Taught Us About Women’s Bodies and Why It Matters Today,” by Dr. Elizabeth Comen

“The New Menopause,” by Dr. Mary Claire Haver
“The New Perimenopause: An Evidence-Based Guide to Surviving the Zone of Chaos and Feeling Like Yourself Again,” by Dr. Mary Claire Haver

...

Menopause Masterclass: Hormones, Brain Fog, Weight & Mental Health with Dr. Mary Claire Haver Jan 06, 2026

Show notes

Dr. Mary Claire Haver breaks down everything you need to know about perimenopause, menopause, and postmenopause in this solo episode, answering critical questions about hormones, symptoms, and treatment with the medical expertise and personal experience that's made her a trusted voice for millions of women.

Most women don't realize perimenopause can begin at 35-36 years old, a full seven to ten years before periods stop. Dr. Haver explains why the first signs are often brain-related: fog, anxiety, feeling like "something's not right," rather than physical changes. Menopause itself is just one day (one year after your last period), but postmenopause represents 30-50 years of life without ovarian hormones. Understanding these three phases changes everything about how women can navigate this transition.

In this episode, Dr. Haver answers questions like: What is menopause and when does it really start? Why am I gaining weight around my middle even though my diet hasn't changed? Why am I suddenly experiencing anxiety and depression? What changes happen to the vagina and bladder? What are my hormone therapy options? And what about testosterone, do I need it?

With estrogen receptors mapped throughout the body, Dr. Haver reveals how declining hormones affect nearly every system. She lists over 40 potential symptoms beyond hot flashes: frozen shoulder, elevated cholesterol, insulin resistance, joint pain, kidney stones, even heightened hearing. Understanding the biology of how your hypothalamus frantically signals ovaries that can't respond explains why menopause impacts so much more than your cycle. She also explains why visceral belly fat triples during this transition regardless of diet and exercise changes, and what that means for long-term health.

Dr. Haver shares a revealing statistic: only 8% of OB-GYN residents feel competent treating menopause, and 77% receive zero menopause training. She explains what doctors should know but often don't: hormone therapy as first-line treatment for mental health changes in perimenopause, prophylactic vaginal estrogen for all perimenopausal women (considered safe even for many breast cancer patients), no mandatory stop date for hormone therapy when benefits outweigh risks, and affordable bioidentical options that exist beyond expensive pellets.

This episode arms you with knowledge to find menopause-educated clinicians, recognize quality care, and demand treatment that actually works. As Dr. Haver emphasizes throughout the episode, no woman should suffer unnecessarily when safe, effective options exist.

Guest links:

Books

“The New Menopause,” by Dr. Mary Claire Haver

Other Resources

The Menopause Society

The Women’s Health Initiative

Dr. Kelly Casperson

Dr. Corinne Menn

Books:

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

Midlife Divorce: The Facts, The Finances, and The Fallout with Jenny Hutt Dec 30, 2025

Show notes

Divorce rates for people over 50 have doubled since the 1990s, and women are initiating the majority of them. What's really driving this shift? In this episode of unPAUSED, Dr. Mary Claire Haver sits down with family law attorney and broadcaster Jenny Hutt to discuss the facts, finances, and fallout of midlife divorce.

Jenny Hutt is a family law attorney specializing in divorce and mediation in New York, and she spent two decades as a broadcaster on SiriusXM. She's one of Dr. Haver's earliest supporters, and she brings both personal experience and professional insight to this conversation about a controversial topic relating to women's health: the connection between menopause and divorce.

Dr. Haver and Jenny start with the facts: the statistics behind gray divorce, why women are initiating most of them, and what's really happening beyond the oversimplification of "dry vagina" causing divorces. They discuss feeling unsupported, undervalued, and reaching a breaking point after years of caregiving. They also dive into finances: what every woman should know about her money whether she's thinking about divorce or not, the three things to do if you're considering divorce, the difference between mediation and legal representation, how to protect inheritance, and the details around a postnuptial agreement. They also address the financial reality that women's household income drops 41% on average after divorce compared to 23% for men. Finally, they explore the fallout: the stress on the sandwich generation of caring for aging parents while raising children, how trauma strains marriages, rebuilding identity after a long marriage, the shame women feel, and why the other side of divorce can bring unexpected peace and freedom.

Guest links:

Jennifer Hutt

Just Jenny Podcast (Apple Podcasts)

Jennifer Koppleman Hutt (Wisselman Harounian Family Law)

Jenny Hutt (e-mail)

Jenny Hutt (Instagram)

Other Resources

U.S. Divorce Rates Down, Marriage Rates Stagnant From 2012-2022 (U.S. Census Bureau)

Women More Likely Than Men to Initiate Divorces, But Not Non-Marital Breakups (American Sociological Association)

Books
“The Galveston Diet: The Doctor-Developed, Patient-Proven Plan to Burn Fat and Tame Your Hormonal Symptoms,” by Dr. Mary Claire Haver

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

Leaving Her Dream Job for Menopause Advocacy: Tamsen Fadal on HRT & Purpose After 50 Dec 23, 2025

Show notes

What happens when a news anchor loses her words on live television and discovers it's not stress, but menopause? Emmy Award-winning journalist Tamsen Fadal joins Dr. Mary Claire Haver to share why she walked away from her dream job in pursuit of changing the conversation around women's health, the powerful story behind her New York Times bestselling book How to Menopause, and her groundbreaking PBS documentary The M Factor.

Tamsen spent 30 years in broadcast journalism without saying the word "menopause" on air—not once. Then perimenopause hit. Brain fog made her skip words on the teleprompter. A hot flash so severe during a live newscast left her sweating and pale, eventually forcing her off the set entirely. Despite erratic bleeding, insomnia, and mounting symptoms, doctor after doctor missed the diagnosis.

But once she understood what was happening, she couldn't stop talking about it. She co-produced The M Factor: Shredding the Silence on Menopause with three other women, self-funding the documentary after she was told there was no audience. The trailer went viral. PBS picked it up. Over 1,000 community screenings followed in 43 countries.

Dr. Haver and Tamsen reflect on meeting at their first menopause conference, the moment they both realized how little training doctors receive, and why this work feels like a calling.

Guest links:

Tamsen Fadal

The Tamsen Show

“The (M) Factor” Documentary

Tamsen Fadal (Facebook)

Tamsen Fadal (YouTube)

Tamsen Fadal (LinkedIn)

Tamsen Fadal (Instagram)

Tamsen Fadal (TikTok)

Books

“How to Menopause,” by Tamsen Fadal

“The New Menopause,” by Dr. Mary Claire Haver