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Google's AI Infrastructure Chief, Amin Vahdat, on the Physics & Economics of Frontier AI Oct 06, 2026

Show notes

At 100,000-accelerator scale, something fails multiple times an hour, which is why Google's Chief Technologist for AI Infrastructure Amin Vahdat thinks FLOPS is a vanity metric. The metric that matters is what he calls goodput: the useful work a workload actually delivers through real failures. Amin walks through the calculus that split the TPU line into 8i and 8t for the first time, why the TPU's core primitives haven't changed since v1, and how Google and DeepMind co-design in the same rooms, intercepting chip architectures mid-flight before tape-out. He explains why long-horizon agents are sending demand for CPUs and storage through the roof alongside accelerators, how optical circuit switches reroute light to a spare rack in milliseconds, and why Google would rather wait on a utility than build its own gigawatt. We also cover orbital data centers and the multi-megawatt rack of 2036.

Hosted by Sonya Huang, Sequoia Capital

0:00 – Introduction

1:47 – What makes a data center an AI data center

5:30 – Goodput, not FLOPS: holding yourself accountable when something fails every hour

11:52 – Doubling token capacity every six months, and where the gains actually come from

15:32 – The TPU bet: from a contrarian call in 2013 to splitting 8i and 8t

23:30 – The case for and against co-design

26:11 – Shoulder to shoulder with DeepMind: intercepting chips mid-flight

34:16 – Long-horizon agents change the shape of the data center

37:50 – Optical circuit switching and the state of networking

42:35 – Power is the binding constraint: utilities, gigawatts, and sizing a data center

49:23 – Training vs. serving clusters, seven-year-old TPUs, and open standards

58:29 – Orbital data centers and the supercomputer of 2036

Box's Aaron Levie: On Reinventing Yourself in the AI Age and Enterprise Diffusion Sep 15, 2026

Show notes

Starting a company is hard. Reinventing your company for AI as a public company with quarterly earnings results is even harder. Aaron Levie has pulled off the transition with Box and offers hard-won advice for founders. The cofounder and CEO of Box argues the value isn't only in the model; it's in the bridge from a model's raw capability to the actual workflow inside a bank, a law firm, or a pharma company. That's the case for the application layer, and Box is building it: an agent harness tuned so tightly to its own file system, permissions, and search that it beats handing the raw API to Claude or ChatGPT on both accuracy and latency. Aaron explains why token subsidies from the labs can't last, why you want a model-agnostic company routing your tokens rather than the one selling them, and why coding diffused fast while the rest of knowledge work won't. (There's no "give us your GitHub" for a sales rep.) His prediction: within five years, 90% of enterprise tokens go to work no human user ever initiated.

Hosted by Sonya Huang, Sequoia Capital

0:00 – Introduction

1:55 – Are application companies the hottest neolabs?

6:56 – Will the labs move up the stack?

12:34 – Box and betting the company on AI

16:50 – Hero use cases: reading a million contracts and long-running agents

18:42 – Work slop: why AI code is embraced but AI content isn't

24:08 – Building Box's agentic harness and the evals that matter

27:23 – The state of the model race

29:25 – Open-weight model adoption in the enterprise

32:34 – Memory, continual learning, and what belongs in the weights

37:29 – Box Labs and systems of record in a world of agents

44:55 – Will chat be the dominant UI for enterprise AI?

48:00 – Why coding diffused fast and the rest of knowledge work hasn't

54:31 – Staying wired in, making a company AI-first, and what it takes to win

Making Cities Awesome: Peregrine’s Nick Noone & Ben Rudolph Sep 01, 2026

Show notes

Most public safety technology companies grow by collecting more data. Peregrine inverted the model: no sensors, no new data, a business built on connecting the data and information cities already own. Co-founders Nick Noone and Ben Rudolph received more than two dozen no's before San Pablo PD let them in the door in February 2018. Today, Peregrine powers law enforcement, emergency medical services, fire and rescue, and other services in more than 400 cities and communities globally. Nick and Ben explain their north star for data sovereignty, and discuss how Peregrine's philosophy and privacy-first approach to data access and ownership preserves individual privacy and cities' sovereignty. They walk through how AI and long-horizon agents are being deployed: a cold case agent that reproduced an exoneration detectives had reached by hand, a Wisconsin county that placed a suspect using cell records buried in 300GB of evidence, identifying threats to a synagogue, root-causing an escalation in weather-related incidents, and more.

00:00 Introduction

02:07 What Forward Deployed Engineering Means

03:58 What Silicon Valley Gets Wrong

05:23 UNHCR, Dimagi And Downstream Data Problems

08:25 Why Cities, Why Safety

10:45 Two Dozen Nos And San Pablo PD

14:19 Building Through Defund The Police

18:16 The Inversion Of The Collection Model

21:20 Data Ownership And Governance

22:57 From Nice Search To Deep Analysis

29:59 Agents Writing The Integrations

31:45 The Cold Case Agent

35:02 The Anti-Network-Effect Proposition

38:40 Facial Recognition And Hard Decisions

40:48 Technology For The Underdogs

42:54 Trusting The Individual Contributor

48:50 Ten Thousand Cities

Parallel’s Parag Agrawal: Building a New Web for AI Agents Aug 25, 2026

Show notes

Parag Agrawal is making a bet that goes against two decades of web search: agents will query the web a thousand times more than humans ever have, and the infrastructure built around human clicks is wrong for them. The former Twitter CEO, now founder and CEO of Parallel Web Systems, explains why Parallel treats human click data as a bug and trains on agent feedback instead. He unpacks the counterintuitive choice to ship a search agent before a search engine, building an index incrementally, and how the new Turbo product cut agentic search to 200 milliseconds. But the problem Parag keeps returning to is economic: the ad-supported internet collapses when agents show up instead of people. His fix draws on Shapley values to pay content owners for the value their pages provide agents, with real dollars reaching publishers, he predicts, within 12 to 24 months.

Hosted by Sonya Huang and Andrew Reed, Sequoia Capital

00:00 Introduction 03:25 What Is Web Search 05:17 Why Start a New Index 07:52 Search Agents First 10:17 Not a Neolab 13:14 Agents vs Google Search 19:38 Inside the Search Stack 28:59 Search Multipliers With Agents 30:21 Meeting Prep Agent Workflows 31:46 Quality Cost Latency And Turbo 32:42 Are Agents Overtaking Humans 34:28 Ads Model Meets Agent Web 37:20 New Incentives For Content 40:48 Shapley Values Attribution 47:46 Parallel Web And Future Vision

Rich Sutton and Khurram Javed: Why AI Models Stop Learning, and How to Start It Again Aug 18, 2026

Show notes

Rich Sutton, who helped pioneer reinforcement learning and wrote the seminal AI essay The Bitter Lesson, has now cofounded Oak Lab with his former student Khurram Javed. Their goal: to build agents that continuously learn from their own experience rather than from us. Rich doesn't think he holds a radical view: "I'm not weird. The field is weird." He says all learning is continual, and the field is the one that needed a new name for it. Rich and Khurram argue synthetic data is "a big mistake." Their "big world hypothesis" is that the world is massively more complex than any agent or simulator, so approximations have to be updated continuously rather than frozen at deployment. Rich calls LLMs an unanticipated scientific breakthrough, but says they represent roughly a quarter of intelligence. He says catastrophic forgetting is "totally curable" with the ideas behind their continual backprop algorithm. Khurram explains why the frontier labs can't follow: they sit in a local minimum where a new paradigm gets worse before it gets better. Their target, five to ten years out, is a trillion-parameter mind that keeps learning, stays coherent, and runs on 20 watts.

Hosted by Sonya Huang and Alfred Lin, Sequoia Capital

00:00 Introduction 02:10 An AI winter, a cancer diagnosis, and the move to Alberta 07:07 Writing "The Bitter Lesson," and what people get wrong 09:53 Are LLMs a positive or a negative example of it? 11:03 Synthetic data is "just a big mistake," and the Big World Hypothesis 18:01 AlphaGo, human priors, and why prior knowledge and learning should be friends 22:37 "Their weights never change": do LLM assistants actually learn? 26:09 Babies, squirrels, and why no animal learns by supervised learning 32:02 Rockets, imagination, and where paradigm shifts come from 36:42 The Alberta Plan and its 12 steps 38:53 Catastrophic forgetting and the cure 43:43 Oak's biggest ambition: a self-maintaining mind 47:56 Why the big labs are stuck in a local minimum 49:13 If everything goes right: LLMs, many minds, and hiring

Chai Discovery's Bitter Lesson: Drug Design Is Another Scaling Problem Aug 04, 2026

Show notes

Most people treat biology as a bespoke, messy science. Josh Meier and Matt McPartlon, co-founders of Chai Discovery, treat it as an engineering problem. They make the case that drug design obeys the bitter lesson: scale data, models, and compute, and the model can learn what a hand-built pipeline simply couldn't capture. The results are concrete: Chai-2 pushed de novo antibody design from a sub 0.1% hit rate to 16%, turning a needle-in-a-haystack search into something more like designing a key to fit a lock. Josh argues, counterintuitively, that biology is more verifiable than code, and explains why the goal should be more lab experiments, not fewer. Their bet: a design suite that collapses drug discovery from nine months to nine days, and arms the pharma industry rather than competing with it.

Hosted by Pat Grady and Sonali Singh, Sequoia Capital

00:00 Introduction 01:52 From Discovery to Design 03:25 Protein AI Breakthroughs Timeline 06:04 Why Start in 2024 10:13 Diffusion Models Intuition 11:41 Building the Avengers Team 15:22 Hit Rates and Scaling Laws 25:01 Molecular CAD Vision 25:24 Faster Design Loops 26:32 Future Drug Discovery 28:37 Platform Business Model 31:14 Partnering Reality Check 33:44 Data Flywheel Explained 37:16 Staying Ahead at Scale 39:44 Culture and What's Next

Building the Automated AGI Lab: Core Automation's Jerry Tworek and Rohan Anil Jul 29, 2026

Show notes

Jerry Tworek led reasoning at OpenAI, convinced that scaling reinforcement learning was the path to AGI. Rohan Anil co-led Gemini pre-training and built the Shampoo optimizer. Now they've teamed up at Core Automation on a contrarian premise: the transformer has carried us as far as it can, and the bottleneck to smarter systems is no longer scale — it's the architecture itself. The missing capability is continual learning, models that adapt at test time, which transformers can't do. In-context learning taps out fast (Codex needs compacting after ~20 minutes) and fine-tuning invites catastrophic forgetting. Rohan argues pre-training and RL should be optimized end-to-end, and that transformers spend computation inefficiently. They lay out why the largest labs won't chase alternatives while locked in the coding-agent race, and why building the world's most automated lab starts with automating kernel generation—the one place frontier models still lose to a high-taste human.

Hosted by Sonya Huang and Pat Grady, Sequoia Capital

Factory's Matan Grinberg: The Coming ‘Dark Factory’ Where Software Builds Itself Jul 21, 2026

Show notes

Factory started building fully autonomous coding agents in April 2023, two years before enterprises were ready. Matan Grinberg now says this is indistinguishable from being wrong. The Factory co-founder and CEO explains how the company survived its "journey in the desert," including the decision to hand nearly all of its revenue back to customers when the product wasn't making developers obsessed. Matan makes the contrarian technical case that a model-agnostic harness beats the model-and-harness co-design that labs like OpenAI and Anthropic favor, because exposing a harness to many models keeps it from overfitting to any single one. He argues open-weight models like GLM will capture the majority of tokens by staying one generation behind the frontier at a fraction of the cost, and that CIOs will soon justify every incremental token the way they justify headcount. Looking ahead, he predicts 90% of coding tokens will run asynchronously—the "dark factory" where software builds itself.

Hosted by Sonya Huang and Pat Grady, Sequoia Capital

Anthropic's Katelyn Lesse & Angela Jiang: Building an Ecosystem, not a Walled Garden Jul 14, 2026

Show notes

Katelyn Lesse and Angela Jiang lead the team building Anthropic's developer platform - the layer that both outside builders and Anthropic's own products run on top of. Angela frames the platform as a three-layer stack: knowledge, execution, and coordination. She argues the real leverage is what’s at the top: "strategies," or meta-harnesses that give each token a different job, from advising to executing to reflecting to memory. On the question of open ecosystem vs. walled garden, they say they aren't precious about owning the stack. Katelyn points to Anthropic's self-hosted sandboxes with partners like Modal, Vercel, and Cloudflare. Whether the work runs on Anthropic's infrastructure or someone else's, what really matters to them is that the architecture is sound. The deeper bet is standards: they hand skills and MCP to the whole industry, build connectors on the MCP spec, and help agents (Claude and non-Claude) work together. The one place they stay closed is model routing: they argue harnesses should be tuned to a model family, so they're designing for Claude rather than routing across models. Angela's frame for the ecosystem bet is electricity: transformative only because everyone could plug in, and no company wired it alone.
Hosted by Sonya Huang and Lauren Reeder, Sequoia Capital

00:00 Introduction

01:49 Two North Stars

02:27 External Builders And Primitives

03:54 What To Externalize

06:00 From Messages To Agents

08:19 Managed Agents Adoption

09:07 Three Layer Cake

10:22 Execution Harnesses Explained

11:09 Coordination Strategies Roadmap

12:13 Ecosystem Standards And Safety

15:39 Open Ecosystem Not Walled

17:12 Vertical Products And Form Factors

22:26 Claude Tag Under The Hood

26:04 Harness Best Practices

38:13 Token Costs And Whats Next

Inside Zipline's Autonomous System: 140M Miles, Zero Incidents Jul 07, 2026

Show notes

The largest commercial autonomous system on earth isn't a robotaxi fleet — it's Zipline, which has flown 140 million autonomous miles with zero safety incidents. Co-founder Keller Rinaudo Cliffton and Eric Watson, who leads systems engineering and safety, explain why the drone itself is only 15% of the solution. The rest spans inventory management, air traffic integration, and engineering systems such as a dual flight computer failover protocol that recently saved a delivery mid-flight. They trace Zipline's path from launching blood delivery in Rwanda in 2016 (when drone delivery was illegal in the US) to a 51% reduction in maternal mortality in that country, a $550 million commercial diplomacy partnership with the State Department, and a cost curve that fell from $300 per delivery to $12. Zipline is now racing toward a million deliveries a day, and a quiet inflection point when autonomous delivery becomes cheaper than sending a car.

Hosted by Alfred Lin and Pat Grady, Sequoia Capital

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