This Week in Virology

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TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection Apr 21, 2020

Show notes

Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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Nonpathogenic enteroviruses to prevent human disease (pdf)
OPV for COVID-19 (pdf)
Enteroviruses to prevent human infections (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 603: Cloudy with a chance of coronavirus Apr 19, 2020

Show notes

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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CpG frequency in SARS-CoV-2 genome (Mol Biol Evol)
SARS-CoV-2 screening before delivery (NEJM)
SARS-CoV-2 seroprevalence in Santa Clara (medRxiv)
SARS-CoV-2 seroprevalence in homeless shelter (NEPR)
Letters read on TWiV 603
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 602: Coronavirus immunology with Stanley Perlman Apr 16, 2020

Show notes

Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Stanley Perlman

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Perlman Laboratory
An Iowa Caucus of Viruses (TWiV 538)
Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight)
T cell responses to respiratory CoV (Immunol Res)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 601: Das coronavirus with Christian Drosten Apr 14, 2020

Show notes

Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

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Links for this episode

Das Coronavirus podcast
Identification of SARS-CoV in Germany (NEJM)
29 nt deletion in genome of SARS-CoV (Sci Rep)
382 nt deletion in genome of SARS-CoV-2 (bioRxiv)
Virological assessment of COVID-19 patients (Nature)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 600: SARS-CoV-2 - enter the Coronials Apr 12, 2020

Show notes

Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Links for this episode

382 nt deletion in genome of SARS-CoV-2 (bioRxiv)
Recombination and mutation leading to SARS-CoV-2 (bioRxiv)
Letters read on TWiV 600
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 599: Coronavirus update - we need a plan Apr 08, 2020

Show notes

Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

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Links for this episode

Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res)
Tiger at NY zoo positive for SARS-CoV-2 (NY Times)
IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv)
Infection fatality rate for managing pandemic (virology blog)
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 598: Who was that masked man? Coronavirus update with Daniel Griffin Apr 05, 2020

Show notes

Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

Restricted dispensing of Plaquenil in NY state
Virology of COVID-19 patients (Nature)
Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_
Cloth face masks for all of US (NY Times)
Masks and respiratory virus shedding (Nat Med)
50 million face masks to Japanese households (Kyodo News)
More than you want to know about face masks (Slate Star Codex)
Why is COVID-19 less severe in children? (virology blog)
Tracking SARS-CoV-2 in sewage (UM)
1918 flattening the curve (Nat Geo)
COVID near you
Pandemic stops polio eradication (Science)
SARS-CoV-2 vaccine patch in mice (U Pitt)
Letters read on TWiV 595
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 597: A lot of immunology and some COVID-19 with Jon Yewdell Apr 03, 2020

Show notes

Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jon Yewdell

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Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 596: COVID-19 - an ounce of prevention Apr 02, 2020

Show notes

TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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Links for this episode

Emergency use of hydroxychloroquine (FDA)
Trial of hydroxycholorquine in COVID-19 patients (China, France)
COVID-19 in critically ill patients, Seattle (NEJM)
Feasibility of convalescent plasma therapy for COVID-19 (medRxiv)
Letters read on TWiV 596
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 595: Coronavirus update - Daniel Griffin MD in the parking lot Mar 29, 2020

Show notes

Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

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Links for this episode