This Week in Virology

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TWiV 624: SeXX matters with Sabra Klein Jun 07, 2020

Show notes

Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein

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Links for this episode

SeXX matters in infectious disease pathogenesis (PLoS Path)
Sex and gender impact immune responses to vaccines (Physiol)
Testosterone and disease severity in mice (Cell Immunol)
Age-associated effects on impact of sex steroids on vaccine responses (NPJ Vaccines)
Evolution of greater humoral immunity in females (Curr Opin Physiol)
Impact of sex and gender on COVID-19 (Biol Sex Diff)
COVID-19 trials should include sex as variable (J Clin Inves)
Global Health 50/50
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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TWiV 623: Bats and coronaviruses with Peter Daszak Jun 04, 2020

Show notes

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak

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Links for this episode

Bats are reservoirs of SARSr-CoV (Science)
Bat SARSr-CoV that binds ACE2 (Nature)
Rich gene pool of bat SARSr-CoV (PLoS Path)
Bat SARSr-CoV infect humans (Virol Sin)
Transmission of bat SARSr-CoV in China (bioRxiv)
Global Virome Project (Science)
ASV Virtual Workshops 2020
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 622: Nonhuman primate model for COVID-19 with Emmie de Wit Jun 02, 2020

Show notes

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Emmie de Wit

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Links for this episode

Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature)
Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv)
Remdesivir for MERS-CoV infection in macaques (PNAS)
ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv)
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 621: An era of COVID-19 poppycock May 31, 2020

Show notes

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Links for this episode

Safety of Ad5 vectored COVID-19 vaccine (Lancet)
Analysis of hydroxychloroquine use (Lancet)
Remdesivir study (NEJM)
Ancient COVID-19 history (MMWR)
Drug repurposing for COVID-19 (bioRxiv)
Why do few COVID-19 patients infect others? (Science)
Overdispersion in COVID-19 transmission (Wellcome Open Res)
Reducing airborne transmission (Science)
Letters read on TWiV 621
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 620: Antibodies and T cells in COVID-19 patients May 29, 2020

Show notes

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Links for this episode

T cell targets in COVID-19 patients (Cell)
SARS-CoV-2 seroconversion in humans (Nat Med)
Convergent antibody responses to SARS-CoV-2 infection (bioRxiv)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 619: Recombination led to emergence of SARS-CoV-2 May 27, 2020

Show notes

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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Links for this episode

Rabadan Laboratory
Understanding Coronavirus (Amazon)
Topological Data Analysis for Genomics and Evolution (Amazon)
Recombination and mutation shaped SARS-CoV-2 (bioRxiv)
Bat CoV with cleavage site insertion (Curr Biol)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 618: Nipah virus at 20 May 26, 2020

Show notes

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 617: Coronavirus Times May 24, 2020

Show notes

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Links for this episode

Playing tennis safely (USTA)
Scientists denounce end to CoV grant (NY Times)
ASMBMB denounces end to CoV grant (pdf)
For TETRIS, turn to Paterson NJ (NY Times)
NJ Dept of Health (image credit)
Differential effects of intervention timing (medRxiv and NY Times)
Texas to stop combining test results (Statesman)
How could CDC make that mistake? (Atlantic)
The Pandemic and Information Network (Columbia Journ Rev)
Helmet and tent (Science)
New song, old melody (Cell Host Microbe)
Letters read on TWiV 617
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 616: Singing about coronavirus May 21, 2020

Show notes

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Links for this episode

Drowning in COVID-19 papers (Science)
CORD-19
2019 NCRC
AI powered literature review
SciSight
Graphical guide to CoV vaccines (Nature)
Moderna Phase I results
Liposomes and lipid nanoparticles (Exelead)
Cigarette smoke increases ACE2 (Dev Cell)
Letters read on TWiV 616
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 615: Peter Daszak of EcoHealth Alliance May 19, 2020

Show notes

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.

Hosts: Vincent Racaniello

Guests: Peter Daszak

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Intro music is by Ronald Jenkees.

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Send your virology questions and comments to twiv@microbe.tv