This Week in Virology

Latest Episodes:

TWiV 319: Breaking breakbone Jan 11, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.

Links for this episode

Efficacy of dengue vaccine (NEJM)
Preventing dengue (NEJM)
Dengue viruses (Scitable)
Intention to treat (Wikipedia)
Image credit: Jean-Yves Sgro
Letters read on TWiV 319

Weekly Science Picks

Alan - The Toaster Project by Thomas ThwaitesRich - SpaceX reusable rocket (SpaceX)Kathy - Antarctica: A Year on IceDickson - NHL Mumps outbreak and Hubble Andromeda image Vincent - We the Microbiologist

Listener Pick of the Week

Neva - Mosquito earrings Basel - Flu vaccine selection meeting

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TWiV 318: Last year in virology Jan 04, 2015

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.

Ten virology stories of 2014

Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283)
Directional uncoating of rhinovirus RNA (TWiV 267)
Pandemic pathogen controversy (TWiV 287)
Viral evolution (TWiV 275)
Borna virus inhibition by endogenous DNA (TWiV 303)
MERS-CoV in dromedary camels (TWiV special, TWiV 287)
Oncolytic measles virus (TWiV 298)
Amazing norovirus findings (TWiV 312 and 313)
Toxin delivery to aphids (TWiV 272)
The Salk Legacy (TWiV 281)

Links for this episode

Bat-filled tree (Science)
Possible Ebola virus lab exposure (CIDRAP)
Mishandling of Ebola virus sample (NY Times)
Where could Ebola virus strike next? (NPR)
New Legos of female scientists
Photo and cookie by Kathy Spindler
Letters read on TWiV 318

Weekly Science Picks

Alan - Mystery photos from CERN Rich - Adam E. Cohen: Bringing bioelectricity to lightKathy - Wired's top microbe stories of 2014Dickson - Mouse joke Vincent - The Science of Epidemics (Time Inc Special)

Listener Pick of the Week

Neva - Sir BacteriophageSagi - An unboring polio documentary

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TWiV 317: Brazil goes viral Dec 28, 2014

Show notes

Host: Vincent Racaniello

Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa

On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.

Video of this episode: view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 316: The enemy of my enemy is not my friend Dec 21, 2014

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis.

Links for this episode

IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS)
Th17 cells involved in influenza mediated gut injury (J Exp Med)
Helper T cells
2014-15 flu season (CDC)
Key facts about flu & flu vaccine (CDC)
Does the flu vaccine work? (Turbid plaque)
Effectiveness of flu vaccine (virology blog)
Image credit
Letters read on TWiV 316

Weekly Science Picks

Alan - It came from the pond Rich - WanderersKathy - The Sense of Style by Steven Pinker Vincent - Life in Our Phage World

Listener Pick of the Week

Fernando - Reality based?

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TWiV 315: Must be something in the water Dec 13, 2014

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.

Links for this episode

National Influenza Immunization Week (CDC)
Densovirus associated with sea star wasting disease (PNAS)
A virus that melts sea stars (virology blog)
Chlorovirus in human oropharynx (PNAS)
Algal virus in humans (virology blog)
Image credit
Letters read on TWiV 315

Weekly Science Picks

Alan - ReelLife Science 2014 Winners Rich - The Martian by Andy WeirKathy - Dance Your Ph.D. Winner Vincent - Time Person of the Year 2014 - The Ebola Fighters

Listener Pick of the Week

Ricardo - MiniPCREli - Let's outsmart Ebola together AND The Ebola virus explained

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TWiV 314: Einstein goes viral Dec 07, 2014

Show notes

Host: Vincent Racaniello

Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.

Links for this episode

Antibodies that protect against Sudan virus (ACS Chem Biol)
Ebola virus entry requires NPC1 (EMBO J)
A toggle switch for virus entry (Nat Comm)
Imaging alphavirus exit (J Virol)
Defects in HIV-1 unable to interact with INI1 (Retrovirol)
Cell cycle arrest by INI1 (Mol Cell Biol)
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 313: With viruses like these, who needs enemas? Nov 30, 2014

Show notes

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.

Links for this episode

Ebola virus update (WHO)
Norovirus can replace functions of gut microbiome (Nature)
Post-vaccinal distemper encephalitis (N Z Vet J)
Novel sea otter poxvirus (J Wildl Dis)
Poliovirus escapes antibodies (virology blog)
CDC whistleblower saga (Sci Based Med)
Snopes on CDC whistleblower
Image credit
Letters read on TWiV 313
Video of this episode - view at YouTube

Weekly Science Picks

Alan - Retrocomputing Rich - Where is Rosetta?Vincent - Antares rocket explosion

Listener Pick of the Week

Simon - Relatively PrimeMark - Giant Microbes

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 312: She sells B cells Nov 23, 2014

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode

Ebola virus appropriations (White House)
ASM Ebola FAQ
Quarantine due to Ebola virus in semen (NPR)
Enteric bacteria promote norovirus infection of B cells (Science)
Norovirus emerges (Zimmer)
Stephanie Karst on TWiV 134
Image credit
Letters read on TWiV 312

Weekly Science Picks

Alan - How Ebola airlifts workKathy - Fred Murphy's Foundations of VirologyRich - Pendulum wave Dickson - Young Dipterists Vincent - Microbes After Hours: Ebola and TWiV iPhone 6 case

Listener Pick of the Week

Alane - Health MapTodd - Formaldehyde in vaccines

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 311: Bulldogs go viral Nov 16, 2014

Show notes

Host: Vincent Racaniello

Guests: Zhen Fu and Biao He

Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses.

Links for this episode

Blood-brain permeability and rabies survival (Antiviral Res)
Rabies induces blood-brain permeability (J Virol)
Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis)
RSV vaccine based on PIV5 (Vaccine)
New mumps vaccine (J Virol)
PIV5-based influenza virus vaccine (J Virol)
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 310: From bacteriophage to retroviruses with Ann Skalka Nov 09, 2014

Show notes

Hosts: Vincent Racaniello and Glenn Rall

Guest: Ann Skalka

Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.

Links for this episode

Skalka laboratory
Asilomar Conference on recombinant DNA
Unexpected inheritance (PLoS Path)
Viral sequences in vertebrate genomes (J Virol)
Assembly of integrase multimers (J Biol Chem)
Cell cycle and retrovirus integration (J Cell Bioch)
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

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