This Week in Virology

Latest Episodes:

TWiV 329: Pox in the balance Mar 22, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.

Links for this episode

Immune signatures in ME/CFS (Science Adv) 11:15
Systemic exertion intolerance disease (Lancet) 19:50
Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10
Poxvirus decapping enzymes prevent innate responses (Cell Host Micr) 1:15:40
Caps off to poxviruses (Cell Host Micr)
Drummer Mohr (YouTube) 1:24:05
Bornavirus in squirrel breeders (ProMedMail) 1:28:45
Principles of Microbial Diversity 5:30
Journal of Microbiology & Biology Education 1:24:25
Cross-stitch by Anne Marie 1:34:40
Letters read on TWiV 329 1:25:00

Timestamps by Jennifer. Thank you!

Weekly Science Picks 1:35:10

Alan - NASA Solar Dynamics Observatory video Rich - Mutagenic chain reaction (Video: Genome editing with CRISPR)Kathy - Science Ambassadors Program Dickson - Street Art Vincent - End Polio Now

Listener Pick of the Week

Ross - Three PhD Comics on Nature vs Science (one, two, three)Ricardo - Demographic Party Trick

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TWiV 328: Lariat tricks in 3D Mar 15, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.

Links for this episode

Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path)
Prp8 protein of the spliceosome (RNA)
Nuclear entry of poliovirus RdRp (Virol)
RNA processing (TWiV 216)
Measles in USA (CDC)
Principles of Microbial Diversity
Journal of Microbiology & Biology Education
Letters read on TWiV 328

Weekly Science Picks

Alan - Positively Negative (PLoS One)Rich - ISS assembly (YouTube)Kathy - Ancient trees Dickson - Carolyn Porco Vincent - Tony Fauci on Ebola outbreak (YouTube)

Listener Pick of the Week

David - Shot by Shot Judi - The Power of Herd Immunity

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TWiV 327: Does a gorilla shift in the woods? Mar 08, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas.

Links for this episode

Traces of ATCV-1 associated with laboratory contamination (PNAS)
ATCV-1 findings not explained by contamination (PNAS)
Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS)
INNO-LIA
Principles of Microbial Diversity
Image credit: John
Letters read on TWiV 327

Weekly Science Picks

Alan - California bill to eliminate personal vaccine exemptions Rich - Kepler observatory (Kepler-186f)Kathy - USGS disease mapDickson - Philosphy of Microbiology by Maureen O'MalleyVincent - Nautilus

Listener Pick of the Week

Ken - Life in our phage world (online, book party); All about that base Neal - Gilles van Cutsem at CROIRicardo - Flow hive

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TWiV 326: Giving HIV a flat tyr Mar 01, 2015

Show notes

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles.

Links for this episode

Dif-tor heh smusma (NY Times)
Immunization preterm premature infants (Thanks, Johnye!)
HIV and SHIV protection conferred by eCD4-Ig (Nature)
Tyrosine sulfation (Wikipedia)
GBV-C and Ebolavirus infection (J Virol)
Letters read on TWiV 326

Weekly Science Picks

Alan - Toms River by Dan FaginRich - Spin by Robert CharlesVincent - FCC votes for net neutrality (ArsTechnica)

Listener Pick of the Week

Neal - Why doesn't everyone get the flu vaccine?Fernando - Zombie Jonas Salk hunts idiotsNeva - Physicists in biology

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 325: Wildcats go viral Feb 22, 2015

Show notes

Host: Vincent Racaniello

Guests: Rollie Clem and Lorena Passarelli

Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses.

Links for this episode

Apoptosis inhibition in A. aegypti (Apop)
Initiator caspase in armyworm (Insect Bioc Mol Biol)
Manipulating apoptosis in A. aegypti (J Virol)
Viral inhibitors of apoptosis (Sem Cell Dev Biol)
Baculoviruses: Sophisticated pathogens (PLoS Path)
Baculovirus morphogenesis (Virol)
Barriers to baculovirus success (Virol)
Baculovirus endonuclease (J Virol)
Baculovirus DNA damage response (J Virol)
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 324: Viruses in the miR may appear more numerous Feb 15, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Lee Feinman

Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus.

Links for this episode

Spin by Robert Charles Wilson
Immunization of preterm infants (Dev Period Med)
miR-122 alters HCV translation-replication balance (Cell Host Micr)
Holding a miR to HCV (TWiV 180)
Treating hepatitis C by blocking miR-122 (virology blog)
Click chemistry (Wikipedia)
Image credit
Ebolavirus sitrep (WHO)
Letters read on TWiV 324

Weekly Science Picks

Lee - Furthering America's Research and Upgoer five and sixAlan - Best snow shovel Rich - Ripple tank Kathy - Fractals Dickson - World Press Photo Contest 2015 Vincent - What to do about antivax politicians and physicians

Listener Pick of the Week

Patricia - Future of Bioscience Graduate & Postdoc training Paul - This is my son Griffin, and he may have measles

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 323: A skid loader full of viromes Feb 07, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis.

Links for this episode

Enteric virome changes in inflammatory bowel disease (Cell)
Gov. Christie stumbles on vaccination (NY Times)
Anti-vax psychology (NPR)
Vaccine skeptic changes her mind (NPR)
Ebolavirus sitrep (WHO)
Letters read on TWiV 323

Weekly Science Picks

Alan - SitesuckerRich - Snake picked wrong dinner Dickson - Sapporo Snow Festival Vincent - Mapping NYC subway DNA

Listener Pick of the Week

Gretchen - Scientific way to cut a cake Leslie - Principles of Virology, Second Edition

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 322: Postcards from the edge of the membrane Feb 01, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.

Links for this episode

Bourbon virus (NY Times)
Thogotovirus (ViralZone)
Drug induced apoptosis and HIV infection (PLoS One)
Mumps cases and outbreaks (CDC)
Opossums as pets? (doc)
Cat found
Letters read on TWiV 322

Weekly Science Picks

Alan - Boom by Tony HorowitzKathy - Octopus supermom Dickson - Macrophotography Vincent - Virology lectures 2015 (virology blog and YouTube)

Listener Pick of the Week

Paul - Illsville: Fight the Disease Ramon - Vaccinate! Do it for the testiclesSandra - Who can you trust?

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 321: aTRIP and a pause Jan 25, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Guest: Paul Duprex

Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.

Links for this episode

Wain-Hobson objects (one, two, three, four)
Influenza H7N1 transmission experiments (J Virol)
Epistemological perspective on aTRIP experiments (mBio)
Limited scientific value and risk (mBio)
Reply to limited scientific value (mBio)
Risks and benefits of aTRIP experiments (mBio)
Apocalypse as rhetorical device in aTRIP debate (mBio)
Moratorium on aTRIP experiments
Moratorium on aTRIP research (mBio)
Risks of influenza virus transmission experiments (mBio)
Reply to risks of influenza virus transmission experiments (mBio)
Vagueness of moratorium on aTRIP experiments (mBio)
Role of aTRIP experiments in vaccine recommendation (mBio)
Use of aTRIP data for surveillance and preparedness (mBio)
aTRIP towards lexiconic precision (mBio)
October 2014 NSABB meeting on aTRIP
NAS aTRIP meeting (YouTube)
MERS-CoV aTRIP experiments exempted (ScienceInsider)
aTRIP: time for a debate (Nat Rev Micro)
Effect of aTRIP moratorium on trainee plans (mBio)
Make the moratorium permanent (Sci Am)
Image credirt: John Morris
Letters read on TWiV 321

Weekly Science Picks

Alan - In a Sunburned Country by Bill BrysonPaul - Saving the lives of our dogs (blog post)Kathy - New all-female Lego set Dickson - Female storm-chaser Vincent - Despommier Photo Art

Listener Pick of the Week

Jacob - Exaggeration in news and press releases (BMJ)Peter - Quartet game (photos: one, two, three, four, five)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 320: Retroviruses and cranberries Jan 17, 2015

Show notes

Host: Vincent Racaniello

Guest: John Coffin

Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries.

Links for this episode

John Coffin (Wikipedia)
Specific HIV integration sites (Science)
Novel retrovirus in modern birds (J Virol)
Recombinant origin of XMRV (Science)
Cranberry harvest (jpg)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

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