This Week in Startups

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DeepSeek Rattles Markets + SailPoint's Going Public… again? | E2077 Jan 27, 2025

Show notes

Today's show: A $6M open-source AI model from China, DeepSeek, sends shockwaves through Wall Street, wiping billions off NVIDIA's market cap and forcing a rethink on AI infrastructure spending. We explore the 25% surge in startup shutdowns, the lessons from leaner teams, and why some companies just couldn't make the runway. Plus, SailPoint returns to the public markets saddled with $1.6B in debt—what does this say about private equity's "buy, fix, and flip" strategy? Don't miss this deep dive into the latest tech and startup news!

Timestamps:

(0:00) Jason and Alex kick off the show. (1:58) DeepSeek's market impact and Project Stargate (4:18) Innovation, H100 GPUs, and open-source AI models (8:41) Jevons paradox, Pat Gelsinger's analogy, and AI efficiency

(10:03) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit https://www.northwestregisteredagent.com/twist today. (13:25) AI's benefits for startups and privacy concerns (19:32) Squarespace. TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST (19:51) AI optimization vs. hardware consumption

(22:20) OpenAI's revenue, valuation, and NVIDIA's market value (30:13) LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist (33:21) Unified AI digital assistants and DeepSeq's new model (35:01) AI's role in venture capital and team size reduction (41:04) China's influence and DeepSeek's market impact (43:22) Startup shutdowns and potential for increased M&A activity (53:02) Nvidia's historical analysis, risks of leverage, and SailPoint's IPO

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(10:03) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit https://www.northwestregisteredagent.com/twist today. (19:32) Squarespace. TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST (30:13) LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist *

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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Twilio Bets Small, DeepSeek Scares & the GameOn Fraud | E2076 Jan 24, 2025

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Today's show: Jason and Alex cover Twilio's team size compression, DeepSeek's scary good AI for only $6M and the GameOn fraud saga that sounds too crazy to be true.

Timestamps:

(0:00) Alex and Jason kick off the show (6:27) Rundown of potential topics (7:10) Twilio's team size strategy and AI's impact on workforce

(9:40) Fitbod. Get 25% off your Fitbod subscription or try out the app for FREE when you sign up: fitbod.me/TWIST (14:52) Entrepreneurship in the AI era and automation concerns

(19:30) Squarespace. TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST (22:49) Meta's investment in data centers and surplus compute power

(26:36) Technology's potential to solve humanity's problems (30:12) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up. (32:01) Empathy for workers displaced by automation (34:11) DeepSeq's role in reducing AI industry costs (37:27) Game On startup fraud case and due diligence in startups (53:13) Venture capital's role in startup oversight (55:36) OpenAI's Operator announcement and AI autonomy risks

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Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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Created By Humans | Sila's Battery Evolution | E2075 Jan 23, 2025

Show notes

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Today's show: Alex covers The Stargate Project, other hot news items, and two great interviews. Created By Humans' Co-founder Trip Adler talks about the future of copyrights and AI. Gene Berdichevsky, Co-founder and CEO of Sila, discusses the future of batteries and our clean energy future.

Timestamps:

(0:00) Alex kicks off the show.(1:22) Introduction to Mistral's IPO, Anthropic's funding, and Project Stargate(6:01) Market reactions and AI funding landscape(10:19) Gusto. Get three months free when you run your first payroll at http://gusto.com/twist(11:35) Tripp Adler discusses AI in literature and Created by Humans(16:20) Authors' concerns and AI companies' reactions(19:42) Netsuite. Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(20:58) Tripp Adler on AI, copyright, and the future of authorship(27:47) Human-created content symbol and synthetic vs. human data

(29:52) Atlassian. Head to Atlassian.com/Startups/TWiST to see if you qualify for 50 free seats for 12 months.(34:08) Gene Berdichevsky on Sila's battery technology and Titan Silicon anodes(41:29) Battery tech's role in industry transformation and consumer devices(48:25) The impact on renewable energy and grid storage(53:02) Hard tech challenges, fundraising, and IPO considerations(56:38) Netflix's quarterly earnings and tech market forecasts

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Created by Humans:

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*Gusto pricing shown in ad is based on pricing prior to March 2025(19:42) Netsuite. Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(29:52) Atlassian. Head to Atlassian.com/Startups/TWiST to see if you qualify for 50 free seats for 12 months.

Great TWIST interviews: Will Guidara,Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta,Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason's suite of newsletters: https://substack.com/@calacanis

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Trump, Memecoins, and What to Expect from the New Administration | E2074 Jan 21, 2025

Show notes

Today's show: Jason and Alex explore America's fascination with billionaires and self-made figures, touching on recent events in Washington, DC, and the tech industry's political influence. They discuss Gen X's rising political power, tech CEOs' prominence at inaugurations, and critique Democrats' tech policies. The conversation covers economic factors in elections, like inflation and abortion rights, COVID's origins, immigration policy, and foreign policy. AI regulation under Biden and Trump's economic strategies, including crypto regulations, are debated. They also discuss Trump's impact on M&A, antitrust laws, and the startup ecosystem, with insights on tech IPOs and tax policy.

Timestamps:

(0:00) Jason and Alex kick off the show. (1:06) Diving into recent DC events and tech's political role (3:13) Gen X's rising political influence and tech CEOs' prominence at inauguration (7:00) Discussion on tech founders' importance and criticism of Democrats' tech stance (10:17) PrizePicks. TWiST listeners, download the app today and use code TWIST to get $50 instantly after you play your first $5 lineup! Go to: https://prizepicks.onelink.me/LME0/TWIST PrizePicks - Run your game. (11:35) Economic factors influencing elections: Inflation and abortion rights (17:15) COVID origins investigation and executive orders affecting tech (19:58) OpenPhone. TWiST listeners can get 20% off your first 6 months at https://openphone.com/twist

(21:25) Steve Bannon, JD Vance, and immigration policy discussions (23:20) US potential territory expansion and foreign policy (30:23) LinkedIn Jobs. TWiST listeners can post their first job for free at https://www.linkedin.com/twist (32:13) Trump's economic strategies, legacy, and US energy production (41:23) AI and drone technology: Regulation and countermeasures (51:05) Crypto's economic value, personal freedoms, and investment risks (1:01:27) Entrepreneur wellness, Trump's EV policies, and state vs. federal regulation (1:04:23) New admin's influence on M&A, antitrust laws, and startup ecosystems (1:09:08) Upcoming tech IPOs, tax policy, and regulatory capture discussion

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(10:17) PrizePicks. TWiST listeners, download the app today and use code TWIST to get $50 instantly after you play your first $5 lineup! Go to: https://prizepicks.onelink.me/LME0/TWIST PrizePicks - Run your game. (19:58) OpenPhone. TWiST listeners can get 20% off your first 6 months at https://openphone.com/twist (30:23) LinkedIn Jobs. TWiST listeners can post their first job for free at https://www.linkedin.com/twist *

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason's suite of newsletters: https://substack.com/@calacanis

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TikTok Ban, Data Centers in Space… and What's a Vector? | E2073 Jan 17, 2025

Show notes

Today's show: Alex sits down with two CEOs from companies freshly added to the TWIST500. We get a masterclass from Bob van Luijt of Weaviate, on vector databases helping AI and LLMs do what they do. An then Philip Johnston from Lumen Orbit explains his vision of building data centers in space!

Timestamps:

(0:00) Alex kicks off the show. (0:58) Supreme Court ruling on TikTok and key market numbers (3:49) Interview introduction with Weaviate and Lumen Orbit CEOs (4:06) Deep dive into vector databases with Weaviate's Bob van Luijt. (8:23) Lemon. TWiST listeners get 15% off your first 4 weeks of developer time at https://Lemon.io/twist (11:35) Exploring deep learning, vector indexing, and Weaviate's open-source significance (18:03) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit https://www.northwestregisteredagent.com/twist ⁠today.

(19:32) Discussion on vector databases use cases and retrieval augmented generation (RAG) (27:17) Weaviate's business model, revenue streams, and growth (28:12) Vanta. TWiST listeners automate your SOC2 and get $1,000 off at http://www.vanta.com/twist (32:52) The future of AI, agentic architectures, and enterprise adoption (40:50) Lumen Orbit's vision for space-based data centers (42:54) Philip Johnston on the technical aspects of Lumen Orbit (49:12) Satellite demonstrators, technology challenges, and VC interest (53:26) Addressing chip obsolescence and cost advantages in space (56:21) Deployment strategies and competition in the space data center market (1:00:12) Strategies for staying ahead of competition and future plans for Lumen Orbit

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Follow Bob:

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(28:12) Vanta. TWiST listeners automate your SOC2 and get $1,000 off at http://www.vanta.com/twist *

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason's suite of newsletters: https://substack.com/@calacanis

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What's Going On With Google Gemini Deep Research? | E2072 Jan 16, 2025

Show notes

This Week in Startups is brought to you by…

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Today's show: Jason and Alex interview Aarush Selvan, lead PM at Google Gemini Deep Research, and discuss their groundbreaking work. They also took a moment to cover TikTok's dire situation and AI investment to start the year.

(0:00) Show Teaser

(1:26) Jason Calacanis shares his Japan skiing experience (6:18) Arush Selvan from Google Gemini team background discussion (9:26) PrizePicks. TWiST listeners, download the app today and use code TWIST to get $50 instantly after you play your first $5 lineup! Go to: https://prizepicks.onelink.me/LME0/TWIST PrizePicks - Run your game. (14:23) Deep research demonstration and server resource usage (19:42) Coda. TWiST listeners get 6 months at https://www.Coda.io/twist (22:11) Google's business model and AI-generated research reports (29:55) Fitbod. Get 25% off your Fitbod subscription or try out the app for FREE when you sign up: fitbod.me/TWIST (32:00) Personalized data integration and content permissions in AI tools (34:22) Differentiation and hallucinations in AI-generated content (44:11) Business models for AI search engines and OpenAI's new task feature (54:30) Synthesia's AI-generated video tool demo and privacy in biometric payments (59:36) Investments in AI companies and TikTok's potential ban (1:04:17) Chinese government influence and US rule of law in tech (1:07:29) Irony of migrating to Little Red Book and upcoming inauguration (1:08:02) Staying updated with This Week in Startups

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Check out Google Gemini Deep Research: https://blog.google/products/gemini/google-gemini-deep-research/

Check out Open AI Scheduling: https://help.openai.com/en/articles/10291617-scheduled-tasks-in-chatgpt

Check out Synthesia: https://www.synthesia.io/

Follow Aarush:

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(9:26) PrizePicks. TWiST listeners, download the app today and use code TWIST to get $50 instantly after you play your first $5 lineup! Go to: https://prizepicks.onelink.me/LME0/TWIST PrizePicks - Run your game. (19:42) Coda. TWiST listeners get 6 months at https://www.Coda.io/twist (29:55) Fitbod. Get 25% off your Fitbod subscription or try out the app for FREE when you sign up: fitbod.me/TWIST

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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Profound, Resistant AI & OpenAI's Economic Pitch | E2071 Jan 14, 2025

Show notes

Today's show: Alex covers Mark Zuckerberg's Joe Rogan interview, OpenAI's economic pitch and the pending IPO of India's Groww. Our guests include two companies freshly added to the TWIST500: James Cadwallader from Profound and Martin Rehak from Resistant AI.

Timestamps:

(0:00) Alex kicks off the show! (2:51) A look at key moments from this week's Mark Zuckerberg interview on Rogan. (8:08) James Cadwallader, Co-Founder and CEO of Profound join Alex. (10:05) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit ⁠https://www.northwestregisteredagent.com/twist⁠ today. (11:23) Comparing Profound's approach to SEO and looking and how problemism impacts search.

(20:21) Paddle. Go to https://www.paddle.com/twist to get started with your exclusive listener fee-free period. (24:48) Building Profound in NYC, business model, and managing LLM costs (30:51) Squarespace. TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST (32:15) Introduction to Resistant AI's mission and building an AI startup (34:18) Resistant AI's approach to fraud detection and criminal techniques evolution (41:17) Shift in the landscape of digital threats and security solutions ROI (51:39) Synthetic fraud detection demonstration and business growth (58:01) The Biden administration's AI diffusion plan and OpenAI's policy recommendations (1:04:25) Groww: India's largest retail stock broker and tech IPO landscape

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Check out Resistant AI: https://resistant.ai/

Follow James:

X: https://x.com/thejamescad

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(10:05) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit ⁠https://www.northwestregisteredagent.com/twist⁠ today. (20:21) Paddle. Go to https://www.paddle.com/twist to get started with your exclusive listener fee-free period. (30:51) Squarespace. TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain: https://www.Squarespace.com/TWIST *

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason's suite of newsletters: https://substack.com/@calacanis

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The LA Fire's Cost and the U.S. Jobs Report | E2070 Jan 10, 2025

Show notes

This Week in Startups is brought to you by…

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Today's show: Jason and Alex cover the LA wildfires and their eventual total cost, as well as the U.S. jobs report and the rise of static team size in tech.

(0:00) Jason and Alex kick off the show. (1:45) Jason's trip to Japan (3:09) Ski industry disputes and resolutions (9:51) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit ⁠https://www.northwestregisteredagent.com/twist⁠ today. (11:07) Ongoing fires in LA, federal aid, and insurance challenges (18:18) Startup Stand Insurance's wildfire risk simulation

(20:18) Atlassian. Head to Atlassian.com/Startups/TWiST to see if you qualify for 50 free seats for 12 months. (24:48) Could people sue the state of California over the wildfires? (29:32) Analysis of California government competence (29:37) LinkedIn Ads. To redeem a $100 LinkedIn ad credit and launch your first campaign, go to http://www.linkedin.com/thisweekinstartups (34:56) Economic impact of job report, inflation, and Trump administration policies (42:31) Inflation's psychological effects and tech industry responses (46:03) Static team size and its effect on the labor market (50:13) Impact of automation and AI on startups and the job market (54:08) TikTok's Supreme Court case begins

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Links to topics that were discussed on the show:

Iwanai Ski Resort: https://iwanairesort.com/

Stand Insurance: https://www.inc.com/bruce-crumley/how-a-startup-plans-to-offer-coverage-to-high-risk-homeowners-dropped-by-big-insurers/91067831

U.S. Jobs Report: https://www.bls.gov/news.release/empsit.nr0.htm

Salesforce Job Freeze: https://www.businesstoday.in/technology/news/story/this-big-tech-company-has-stopped-hiring-coders-due-to-boost-provided-by-ai-460260-2025-01-10

Thank you to our partners:

(9:51) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit ⁠https://www.northwestregisteredagent.com/twist today. (20:18) Atlassian. Head to Atlassian.com/Startups/TWiST to see if you qualify for 50 free seats for 12 months. (29:37) LinkedIn Ads. To redeem a $100 LinkedIn ad credit and launch your first campaign, go to http://www.linkedin.com/thisweekinstartups

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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Meta's Moderation and Nvidia's Domination | E2069 Jan 08, 2025

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This Week in Startups is brought to you by…

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*Gusto pricing shown in ad is based on pricing prior to March 2025

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Today's show: Jason and Alex discuss Meta's moderation announcement, Nvidia's seeming domination in the processor space, Anthropic's $2B raise and some fun products coming out of CES.

(0:00) Jason and Alex kick off the show.(5:15) Fire in Pacific Palisades and Malibu: Insurance and Startup Opportunities(9:48) Gusto. Get three months free when you run your first payroll at http://gusto.com/twist(17:32) Meta's New Content Moderation Strategy and Zuckerberg's Motivations(20:09) Oracle. ⁠⁠TWiST listeners can try OCI and save up to 50% on your cloud bill at https://w⁠⁠⁠⁠ww.oracle.com/twist⁠⁠⁠

(22:35) More on Zuck's motivations and what the new president can do(30:30) Squarespace. TWiST listeners: use code TWIST to save 10% off your first purchase of a website or domain:https://www.Squarespace.com/TWIST(40:26) NVIDIA's AI Supercomputer Chip and Tech Industry Innovations(49:15) Lenovo's Rollable Laptop and Slack's iOS Integration(56:31) BYD's Supercar and Anthropic's Valuation(1:02:45) Jason's Experience with Luxury Japanese Minivans

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