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    Natural Sciences

    This Week in Evolution

    This Week in Evolution is a podcast on the biology of what makes us tick. Hosts Nels Elde and Vincent Racaniello take you through the new evolution that has been revolutionized by the field of genomics and molecular biology.

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    Copyright: © Copyright 2022 Vincent Racaniello

    • Apple Podcasts
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    Latest Episodes:
    TWiEVO 106: What's old immunity is new again Sep 30, 2024

    Nels and Vincent explain how homology searches of anti-phage systems in eukaryotic genomes can be used to discover proteins of the human immune system.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Human antiviral effectors from antiphage systems (Cell Host Micro)
    • Timestamps by Jolene
    Science Picks

    Nels – Pathoplexus.org Vincent – Can science cure its addiction to plastic?

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 105: Not every rose has its thorn Sep 30, 2024

    Nels and Vincent look at how plant prickles, sharp epidermal projections that provide defense from predators and other advantages, arose by convergent evolution, the emergence of analogous traits in distantly related species.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Convergent evolution of plant prickles (Science)
    • Timestamps by Jolene
    Science Picks

    Nels – Trees as a metaphor to understand relationships in biology Vincent – Project 2025 vs. The Public’s Health

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 104: Wooly mammoth prosciutto Jul 31, 2024

    Nels and Vincent discuss the genome sequence of an ancient wooly mammoth, which shows that the three-dimensional architecture of the DNA can persist after 50,000 years.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Three dimensional architecture of 50,000 year old wooly mammoth genome (Cell)
    • Timestamps by Jolene
    Science Picks

    Nels – Mysterious SARS-CoV-2 variants showing up in sewer samples Vincent – ‘Cocaine sharks’ found in waters off Brazil

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 103: Change the world by duplicating yourself Jul 09, 2024

    Nels and Vincent explore a direct experimental test of Ohno’s Hypothesis, which states that gene duplication can help genes tolerate new mutations and thus facilitates the evolution of new phenotypes.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • Join the MicrobeTV Discord server
    • Direct test of Ohno’s Hypothesis (eLive)
    • Timestamps by Jolene
    Science Picks

    Nels – Experimental Evolution and the Nature of Biodiversity Vincent – Is science’s dominant funding model broken?

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 102: Kelp gets some viral help May 09, 2024

    Nels and Vincent explain how deep genomics of macroalgae illuminate multiple paths to aquatic, photosynthetic multicellularity.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • Join the MicrobeTV Discord server
    • Paths to aquatic, photosynthetic multicellularity (Mol Plant)
    • Timestamps by Jolene
    Science Picks

    Nels – 12-sided Roman relic baffles archaeologists, spawns countless theories Vincent – TWiEVO 11: Microbial accomplices in multicellularity and the follow up Synergistic Cues from Diverse Bacteria Enhance Multicellular Development in a Choanoflagellate

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 101: 99 problems but a tail ain't one May 08, 2024

    Nels and Vincent review the genetic basis for tail-loss evolution in humans and apes.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • Join the MicrobeTV Discord server
    • Genetic basis of tail loss evolution in apes (Nature)
    • Timestamps by Jolene
    Science Picks

    Nels – Will Brie and Camembert Cheeses Go Extinct? Vincent – A True Human Tail in a Neonate: Case report and literature review

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 99: A shocking means to move genes May 08, 2024

    Nels and Vincent reveal how electric organ discharge from the electric eel facilitates the introduction of DNA into teleost larvae.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • Join the MicrobeTV Discord server
    • Electric eel discharge moves DNA into cells (Peer J)
    • Timestamps by Jolene
    Science Picks

    Nels – “The Jump” quilt by Cristina Arcenegui Bono Vincent – T4 bacteriophage art object and Gwenbeads Etsy shop

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 100: Spaces that celebrate science Mar 10, 2024

    Rich Condit joins Nels and Vincent at the Science Mill in Johnson City, Texas, where Director of STEM Education Jeehyun Park talks about the goals of the childrens’ museum.

    Hosts: Nels Elde, Vincent Racaniello, and Rich Condit

    Guest: Jeehyun Park

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • Join the MicrobeTV Discord server
    • The Science Mill
    • Timestamps by Jolene
    Science Picks

    Nels – Science Mill: More Than a Museum and Elde Lab Video Rich – The Moon May Get Its Own Time Zone (Claire Fahy, NYT 3/7/2023) Vincent – SXSW Session “From Adversary to Ally: Reimagining Viruses as Medicines“

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 98: The worms strike back! Feb 27, 2024

    Nels and Vincent discuss how behavioural individuality determines infection risk in clonal ant colonies.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Infection risk in clonal ant colonies (Nat Comm)
    • Timestamps by Jolene
    Science Picks

    Nels – Fungi (lichens) in Space Vincent – Polar bear energetic and behavioral strategies on land with implications for surviving the ice-free period

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 97: Germs trapping worms Feb 27, 2024

    Nels and Vincent review a study of the key processes required for the different stages of fungal carnivory by a nematode-trapping fungus.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Fungal carnivory by a nematode-trapping fungus (Plos Biol)
    • Timestamps by Jolene
    Science Picks

    Nels – Openly available illustrations as tools to describe eukaryotic microbial diversity Vincent – Dana-Farber retractions: meet the blogger who spotted problems in dozens of cancer papers

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 96: Going bananas over the origins of corn Dec 26, 2023

    Nels and Vincent discuss the origins of two modern day agriculturally important plants: a role for two different wild teosintes in making modern maize, and the origin and evolution of the triploid cultivated banana genome.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Two teosintes made modern maize (Science)
    • Teosinte (Native Seeds)
    • Evolution of triploid banana genome (Nature)
    Science Picks

    Nels – Why we need an academic career path that combines science and art – Nature Careers Podcast Vincent – Science’s 2023 Breakthrough and Breakdown

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 95: Watering the viruses until they bloom Nov 14, 2023

    Nels and Vincent discuss how the rewetting of seasonally dried soils, a critical event in Mediterranean grasslands that reactivates dormant soil microorganisms, leading to pulses of carbon and nitrogen mineralization, and is accompanied by a bloom of viral diversity, followed by extensive viral community turnover.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Join the MicrobeTV Discord server
    • Viral but not bacterial community successional patterns reflect extreme turnover shortly after rewetting dry soils
    Science Picks

    Nels - Bluesky Vincent - Cancer Virus Hunters: A History of Tumor Virology

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 94: A bacteria, a phage, and a selfish element walk into a cryptomonad Sep 29, 2023

    Nels and Vincent take apart an amazing symbiosis consisting of two bacteria, one bacteriophage, and seven different genomes all within a single-celled alga.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode

    •Join the MicrobeTV Discord server •A single crowded cryptomonad cell (Curr Biol) •Letters read on TWiEVO 94

    Science Picks

    Nels – What happened at NIH during the last government shutdown Vincent – Geneticist J. Craig Venter: ‘I consider retirement tantamount to death’

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 93: Faster than a speeding bacteria Aug 25, 2023

    Nels and Vincent review a collision of synthetic biology and experimental evolution, using a minimal synthetic bacterial cell with only 473 genes, the smallest genome of any known organism that can be grown in lab culture.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode

    •Join the MicrobeTV Discord server • Evolution of a minimal cell (Nature)

    Science Picks

    Nels – Life magnified stamp collection

    Vincent – Matters Microbial

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 92: There's algae in the jar Jul 21, 2023

    Nels and Vincent explain a study of how interspecies competition between two algae influences evolution of metabolism and size.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode

    •Join the MicrobeTV Discord server • Metabolic evolution during competition (Curr Biol)

    Science Picks

    Nels – How amino acids got their names (Source)

    Vincent – EVs Fix One Pollution Problem—And Worsen Another

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 91: Meet your very distant cousins Jul 17, 2023

    Nels and Vincent discuss new findings using phylogenetic approaches about how complex eukaryotic cells emerged from prokaryotic ancestors, which firmly place eukaryotes as a clade nested within the Asgard archaea.

    Hosts: Nels Elde and Vincent RacanielloS

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode

    •Join the MicrobeTV Discord server •Heimdallarchaeial ancestry of eukaryotes (Nature)

    Science Picks

    Nels – Juneteenth issue of Cell – collection of essays from black and brown scientists

    Vincent – Tara Oceans

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 90: The mystery of the mouse mummies May 12, 2023

    Nels and Vincent provide insights into the mystery of mouse mummies on the summits of >6000 m Andean volcanoes, including whether they were living there and if so why?

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode

    •Join the MicrobeTV Discord server •Mystery of mouse mummies (bioRxiv)

    Science Picks

    Nels – Zoonomia Vincent – SeaPhages

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 89: On the outer rim of tumor evolution Apr 25, 2023

    Nels and Vincent discuss the observation that cells on a boundary of a solid tumor have higher growth rates compared to those in the center and how to model this difference using genome sequencing data.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode

    •Join the MicrobeTV Discord server •Evolutionary models of solid tumor growth (Nat Ecol Evol)

    Science Picks

    Nels – TWiV 1000 Vincent – The dream of wiping out polio might need a rethink

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 88: Dog days of evolution in the shadows of Chernobyl Mar 26, 2023

    Nels and Vincent review a study of the dogs of Chernobyl which reveals that genetically distinct populations with different amounts of western breed contributions to their genomes, the first step in assessing the effects of exposure to long-term ionizing radiation.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode

    •Join the MicrobeTV Discord server •The dogs of Chernobyl (Science Adv) •What the dogs of Chernobyl can teach us (Stat) •Letters read on TWiEVO 88

    Science Picks

    Nels – Hellbent documentary and Insufficient evidence for natural selection associated with the Black Death Vincent – BioRender

    Listener Pick

    Walter – Oded Rechavi and interview

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 87: Nathan Clark's revolutionary hair care advice Feb 21, 2023

    Nathan joins Nels and Vincent to discuss his approach to understanding how species adopt novel traits to overcome challenges, and its application to identifying coding and noncoding sequence changes that underlie mammalian hairlessness.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Nathan Clark

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode

    •Join the MicrobeTV Discord server •Gene loss in marine mammals (TWiEVO 34) •Gene change underlying mammalian hair loss (eLife) •Letters read on TWiEVO 87

    Science Picks

    Nels – Local news coverage of Amanda, Maria, and Nathan’s paper Vincent – Discovering Retroviruses by Anna Marie Skalka Nathan – Genomics of Secondarily Temperate Adaptation in the Only Non-Antarctic Icefish

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 86: Pulling out the stops in genetic code evolution Feb 05, 2023

    Nels and Vincent discuss how evolution of changes in stop codon assignment might occur, and a novel mechanism for altering the meaning of translation stop codons discovered in a trypanosomatid with the apropos name, Blastocrithidia nonstop.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode

    •Join the MicrobeTV Discord server •Novel stop codon reassignment mechanisms (Nature)

    Science Picks

    Nels – Protein Synthesis: An epic on the cellular level

    Vincent – Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genes discussed on TWiM 277

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 85: Teaching old dogs new genetic tricks Dec 21, 2022

    Nels and Vincent discuss the use of genome sequence data for over 4,000 domestic, semi-feral, and wild canids to understand the genetic drivers of canine behavior.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Genetic drivers of canine diversification (Cell)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Ghosts of Science Past Still Haunt Us by C. Brandon Ogbunu Vincent – The Biggest Ideas in the Universe by Sean Carroll

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 84: Decoding our defenses to the Black Death Nov 08, 2022

    Nels and Vincent review the use of ancient DNA to identify loci that may have been under selection during the Black Death by studying populations before, during, and after the pandemic.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Evolution of immune genes associated with Black Death (Nature)
    • ERAP2 and respiratory disease (medRxiv)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Interview with Paul Turner in Current Biology and Map of the World if you are a fish Vincent – Smallpox and its eradication

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 83: Evolution spreads its wings (and then loses them) Oct 24, 2022

    Florian Maderspacher from Current Biology joins Nels and Vincent to discuss a special issue of the journal on birds.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Florian Maderspacher

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Current Biology Birds Special Issue
    • Scott Edwards bikes across the US (Audubon)
    • Support Diversity Issues in Evolution (Go Fund Me)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Florian – Favorite birds of authors/contributors in Birds issue Nels –Loss of avian intromittent organs as a sperm competition strategy: a race to be last Vincent – Malaria at the Bronx Zoo (TWiP 110)

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 82: A genetic hack for the human brain Sep 25, 2022

    Nels and Vincent consider evidence that a single amino acid change in the TKTL1 gene might have led to greater neurogenesis in the frontal cortex of modern humans compared with Neanderthals.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Human TKTL1 implies greater neurogenesis (Science)
    • Everyone’s a little bit Neanderthal (TWiEVO 8)
    • Tragic gene flow from Neanderthals (TWiV 676)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Unusual display of elements Vincent – Sykdomspulsen and summary

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 81: Evolution's new and improved slime molds Aug 24, 2022

    Nels and Vincent discuss how duplication of a gene encoding a transcription factor led to evolution of a novel cell type in the slime mold Dictyostelium.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Gene duplication leads to novel cell type (Current Biol)
    • Evolution of multicellularity (TWiEVO 11)
    • Letters read on TWiEVO 81
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Dall-E artificial intelligence meets art Vincent – John Bonner’s slime mold movies

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 80: Viruses of a feather bottleneck together Aug 01, 2022

    Louise Moncla joins Nels and Vincent to review her use of genomics to understand emergence, evolution, and transmission of respiratory viruses including influenza virus H5N1, mumps virus, and SARS-CoV-2.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Louise Moncla

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Within-host diversity of influenza virus H5N1 (PLoS Path)
    • Mumps virus outbreak in Washington (eLive)
    • SARS-CoV-2 tight transmission bottlenecks (PLoS Path)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – JWST Images Vincent – 3rd International Symposium on Infectious Diseases of Bats and Program

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 79: When the immune system is away, SARS-CoV-2 will play Jul 02, 2022

    Nels and Vincent discuss an analysis of the drivers of evolution of SARS-CoV-2 during chronic infections, indicating that a tradeoff exists between antibody evasion and fitness.

    Hosts: Nels Elde and Vincent Racaniello

    Click arrow to play Download TWiEVO 79 (103 MB .mp3, 86 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • SARS-CoV-2 evolution during chronic infection (Nat Med)
    • Letters read on TWiEVO 79
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – NASA scientists say images from the Webb telescope nearly brought them to tears Vincent – FDA: Don’t rush a move to change the Covid-19 vaccine composition

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 78: The virus daily double May 26, 2022

    Nels and Vincent provide an update on cases of monkeypox, and summarize a biochemical view of three changes in the SARS-CoV-2 spike protein that may balance positive and negative selection.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • ECDC monkeypox risk assessment (pdf)
    • Monkeypox virus genomes (Nextstrain)
    • Discussion of monkeypox virus genome sequencing (virological.org)
    • Balancing positive and negative selection in spike protein (Biochem)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Science on the Side podcast by Morgan Nelson and Ty Chiaro Vincent – Richard Ernst Lecture 2022

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 77: The mutations of our lives Apr 26, 2022

    Alex joins Nels and Vincent to discuss his work which demonstrates that somatic mutation rates scale with lifespan in mammals.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Alex Cagan

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • Somatic mutation and age (Nature)
    • Zombie gene in elephants (TWiEVO 26)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Alex – Paper.app Nels – Fifty years since Lewontin’s apportionment of human diversity Vincent – An Exceptional Village

    Listener Pick

    Martha – Plagues Upon the Earth by Kyle Harper

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 76: One-step symbiosis Mar 22, 2022

    Nels and Vincent describe how a single amino acid change can allow E. coli to replace the essential gut symbiont of the stinkbug Plautia stali.

    Hosts: Nels Elde and Vincent Racaniello

    Click arrow to play Download TWiEVO 75 (103 MB .mp3, 86 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • Making E. coli an insect mutualist (bioRxiv)
    • Letters read on TWiEVo 76
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Inequality in science and the case for a new agenda Vincent – Foundations of Virology by Fred Murphy

    Listener Pick

    Sam – Saturday Morning Breakfast – Evolutionist

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 75: Even the BANAL coronaviruses are interesting Feb 24, 2022

    Nels and Vincent review isolation of SARS-CoV-2-like viruses from bats in Laos that can replicate in human cells.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • SARS-CoV-2 like viruses in bats in Laos (Nature)
    • Vampire vax (TWiV 809)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Erich Jarvis on scientists and public engagement Vincent – Polio type 1 in Africa

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 74: On racism, not race with Joe Graves Feb 03, 2022

    Joe Graves joins Nels and Vincent to discuss his career in evolutionary biology and his recent book that answers questions about race and racism.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Joe Graves

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiEVO

    Links for this episode
    • On Racism, Not Race (Amazon)
    • African Americans in evolutionary science (Behav Ecol Sociobiol)
    • Biological variation and the normal (Am J Hum Biol)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Where is Webb? Vincent – Black Microbiologists Association Joe – Biology versus bias

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 73: With a little help from your hosts Dec 28, 2021

    Nels and Vincent review three aspects of SARS-CoV-2: phylogenetics of Omicron, a two-step fitness selection for variants, and putative RNA insertions from host genomes.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Two-step fitness selection for SARS-CoV-2 variants (Cell Rep)
    • Host origins of SARS-CoV-2 genome insertions (Virological)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Plant virus satellite accelerates wing formation in insect Vincent – A plant virus that switched to vertebrates

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 72: Echoes of evolution both shallow and deep Oct 26, 2021

    Nels and Vincent discuss evolutionary evidence for an epidemic of coronavirus infection over 20,000 years ago in East Asia, and reconstruction of the membrane differences between bacteria and Archaea reveals unexpected differences in permeability.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Ancient coronavirus epidemic in East Asia (Curr Biol)
    • Gene-culture coevolution and human evolutionary transition (Proc Roy Soc B)
    • Membrane permeability at the lipid divide (bioRxiv)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Slowed canonical progress in large fields of science Vincent – Virology Live

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 71: Faster than a speeding coronavirus Sep 27, 2021

    Nels and Vincent explain a method to calculate the mutation rate of SARS-CoV-2, and the role of a single amino acid change in spike in enhancing fitness of the delta variant and enabling it to out-compete the alpha variant.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • SARS-CoV-2 mutation rate (Genome Biology Evolution)
    • Delta spike change enhances fitness (bioRxiv)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Leading Edge Symposium Vincent – Epidemiological and evolutionary dynamics of SARS-CoV-2

    Listener Pick

    Thomas – The gene’s-eye view of evolution by J. Arvid Ågren

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 70: On Life's Edge with Carl Zimmer Aug 03, 2021

    Carl Zimmer joins Nels to talk about science writing, science communication, viruses, and his new book, On Life’s Edge.

    Host: Nels Elde

    Guest: Carl Zimmer

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    Links for this episode
    • On Life’s Edge by Carl Zimmer
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Remembrance of Dick Lewontin Carl – From telomere to telomere: the transcriptional and epigenetic state of human repeat elements

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    TWiEVO 69: Swimming in SARS-CoV-2 sequences Jun 30, 2021

    Nels and Vincent discuss the identification of novel bat coronaviruses that shed light on the evolution of SARS-CoV-2, dating the first cases of COVID-19 to mid-November 2019, and recovery of deleted genome sequences from early in the Wuhan outbreak.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Identification of novel bat coronaviruses (Cell)
    • Dating first cases of COVID-19 (PLoS Path)
    • Recovery of deleted SARS-CoV-2 sequences (bioRxiv)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – The Last—And Only—Foreign Scientist in the Wuhan Lab Speaks Out Vincent – Human Behavior During the Pandemic Is More Important Than Any Covid Variant

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    TWiEVO 68: Stepping through time with SARS-CoV-2 May 29, 2021

    Nels and Vincent explain a new method for calculating the most recent common ancestor of SARS-CoV-2, which concludes that the ancestral virus was circulating in October/November 2019, before its first detection in China.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Evolutionary portrait of SARS-CoV-2 (Mol Biol Evolution)
    • Letters read on TWiEVO 68
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Ed Yong pandemic trauma and We’re Not Ready for the Next Pandemic Vincent – Furin cleavage site is not a smoking gun

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    TWiVEO 67: Corona chameleon Apr 22, 2021

    Nels and Vincent review evidence for recombinant SARS-CoV-2 genomes arising in the B.1.1.7 lineage within the United Kingdom.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Recombination in B.1.1.7 lineage (Virological)
    • CoVariants
    • Letters read on TWiEVO 67
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Mars rover helicopter flight! Vincent – TWiN 17: Worms see the light with Michael Nitabach

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    TWiEVO 66: SARS-2-mouse Mar 25, 2021

    Nels and Vincent review a preprint demonstrating that changes in the genomes of the SARS-CoV-2 variants B1.351 and P.1 allow the viruses to reproduce in mouse cells in culture and in laboratory mice.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Tony Schountz on TWiV 668
    • SARS-CoV-2 variants infect mice (bioRxiv)
    • CoVariants
    • Letters read on TWiEVO 66
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Billion years of plate tectonics Vincent – Sapiens a Graphic History by Yuval Noah Harari

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    TWiEVO 65: Variants in the mist Feb 25, 2021

    Nels and Vincent review evidence that a single amino acid change in the SARS-CoV-2 spike protein has driven adaptation to humans, followed by an update on the status of variants of concern.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Selective sweep drove SARS-CoV-2 adaptation (bioRxiv)
    • Novel coronavirus haplotypes
    • Letters read on TWiEVO 65
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Radio Garden Vincent – Our World in Data – Coronavirus

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    TWiEVO 64: Seeing the lineages for the variants Jan 22, 2021

    Nels and Vincent consider evolution of antibody immunity to SARS-CoV-2, and update the situation on novel virus variants of concern with potentially altered fitness and reactivity with antibodies.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Evolution of SARS-CoV-2 antibodies (Nature)
    • mRNA vaccine-elicited antibodies to variants (bioRxiv)
    • Scott Hensley thread (Twitter)
    • Analysis of B.1.17 lineage (virological)
    • Trevor Bedford thread (Twitter)
    • Andrew Rambaut on variant naming (Twitter)
    • Letters read on TWiEVO 64
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Biden Administration PCAST and The Hill We Climb Vincent – Four inaugural quotations – Lincoln, Roosevelt, Kennedy, Biden

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    TWiEVO 63: Year of the coronavirus Dec 31, 2020

    Nels and Vincent wrap up 2020 with a discussion of novel variants of SARS-CoV-2 that have emerged in the United Kingdom and South Africa, how to interpret the rapidly emerging genome sequence data and what to look for in the coming weeks as these variants spread across the globe.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode
    • Preliminary genomic characterization of UK variant (virological)
    • Clinical outcomes of infection with Orf8 variants (Lancet)
    • Global Report Investigating Novel Coronavirus Haplotypes (GRINCH)
    • South African SARS-CoV-2 lineage (medRxiv)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Katalin Karikos’ career and mRNA vaccines Vincent – Reverse Engineering of mRNA vaccine

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    TWiEVO 62: Army ants with Daniel Kronauer Dec 07, 2020

    Daniel joins Nels and Vincent to discuss his new book on army ants, the wickedest insects ever to roam the planet, and his research on them and clonal raider ants.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Daniel Kronauer

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    Links for this episode
    • This Week in Ants (TWiEVO 13)
    • Raiders of the Lost Orco (TWiEVO 18)
    • Army Ants by Daniel Kronauer
    • Time stamps by Jolene. Thanks!
    Science Picks

    Daniel – Desert Navigator by Rüdiger Wehner and Insects of Suriname by Maria Sibylla Merian Nels – NPR Scicommers Vincent – The Vintage Beauty Of Soviet Control Rooms

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    TWiEVO 61: Shot and chaser of SARS-CoV-2 evolution Oct 31, 2020

    Nels and Vincent discuss an opinion piece on 12 evolutionary insights into how the COVID-19 pandemic is shaping human nature, and prolonged SARS-CoV-2 reproduction in an immunosuppressed patient.

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    Links for this episode
    • Microbe.TV on instagram
    • Pandemic exposes human nature (PNAS)
    • Carl Bergstrom calls BS (Twitter)
    • Prolonged SARS-CoV-2 reproduction in patient (J Inf Dis)
    • Letters read on TWiEVO 61
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels – Scott Edwards bikes across US; support diversity in evolution Vincent – 30 computers sculpture project

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    TWiEVO 60: Five years of TWiEVO on the future of our past Sep 25, 2020

    On the fifth anniversary of TWiEVO, Nels and Vincent invite 12 evolutionary biologists to describe exciting future directions for the field and their laboratory in the next five years.

    Hosts: Nels Elde and Vincent Racaniello

    Guests: Lillian Fritz Laylin, Talia Karasov, Andrew Kern, Sarah Tishkoff, Dmitri Petrov, Nancy Chen, Amanda Larracuente, John McCutcheon, Ambika Kamath, Chip Aquadro, Rebekah Rogers, Yaniv Braindvain, and Harmit Malik

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    Science Picks

    Nels - Science Mill Virtual Tour and Benefit Vincent - Das Coronavirus summaries

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    TWiEVO 59: The hypothesis giving tree Aug 28, 2020

    Nels and Vincent answer listener questions and discuss a newly discovered virus of amoeba with a nearly complete ORFan genome: none of the proteins encoded in the viral genome look like any other proteins.

    Hosts: Nels Elde and Vincent Racaniello

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    Links for this episode

    • Yaravirus (PNAS)
    • Letters read on TWiEVO 59
    • Time stamps by Jolene. Thanks!

    Science Picks

    Nels - Blog by Ambika Kamath Vincent - TWiVerse

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 58: Not all coronaviruses ACE2 the test Aug 13, 2020

    Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus.

    Hosts: Nels Elde and Vincent Racaniello

    Guests: Simon Anthony and Heather Wells

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    Links for this episode

    • Evolutionary history of sarbecovirus ACE2 binding (bioRxiv)
    • Bombali virus in bats (Nat Micro)
    • Herpesviruses in Puerto Rican bats (bioRxiv)
    • Adenovirus and herpesvirus in great apes (PLoS One)
    • Time stamps by Jolene. Thanks!

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 57: SARS-CoV-2 receptor binding evolution blooms Jun 24, 2020

    Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.

    Hosts: Nels Elde and Vincent Racaniello

    Guests: Jesse Bloom, Allie Greaney, and Tyler Starr

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    Links for this episode

    • Bloom Laboratory
    • Deep mutational scanning of SARS-CoV-2 RBD (bioRxiv)
    • Time stamps by Jolene. Thanks!

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 56: Revising the drafts of coronavirus evolution May 20, 2020

    Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.

    Hosts: Nels Elde and Vincent Racaniello

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    • SARS-CoV-2 genomic diversity (Inf, Genet, Evol)
    • Re-emergence of SARS-CoV-2 (bioRxiv)
    • Tackling SARS-CoV-2 rumors (virological.org)
    • Letters read on TWiEVO 56
    • Image credit
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - The Cell in Evolution Vincent - Visual Science

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    TWiEVO 55: Coronavirus evolution from soup to nuts May 06, 2020

    Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.

    Hosts: Nels Elde and Vincent Racaniello

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    • CoV proofreading enzyme stimulates recombination (bioRxiv)
    • CoV spike mutation pipeline (bioRxiv)
    • Issues with CoV sequencing data (virological.org)
    • Bill Hanage on selection vs bottleneck (threader.app)
    • Image credit
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - In Memoriam: Gordon Lark Vincent - John Oliver Discussion of Antibody Tests

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    TWiEVO 54: Rough drafts of SARS-CoV-2 science Apr 25, 2020

    Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology.

    Hosts: Nels Elde and Vincent Racaniello

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    • SARS-CoV-2 in Vero cells (bioRxiv)
    • More related SARSr virus from bat (bioRxiv)
    • Patient isolates in Vero cells (medRxiv)
    • Nomenclature for genomic epidemiology (bioRxiv)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - EvoEco seminars Vincent - Coronavirus book for children

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    TWiEVO 53: Virus evolution by land and by sea and by CoV, part II Apr 04, 2020

    Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.

    Hosts: Nels Elde and Vincent Racaniello

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    • Clement Chow with COVID-19 (Salt Lake Trib)
    • Scientists exposed to coronavirus (Nature)
    • CoV by Britt Glaunsinger (YouTube)
    • Genetic epidemiology of novel coronavirus (nextstrain.org)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - Science Mill Explorer Zone Vincent - COVID-19 treatment and therapy tracker

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    TWiEVO 52: Virus evolution by land and by sea and by CoV Feb 26, 2020

    Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

    Hosts: Nels Elde and Vincent Racaniello

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    • Distinct CoV name needed (Lancet)
    • Proximal origin of SARS-COV-2 (virological)
    • CoV spillovers not rare (Goats and Soda)
    • SARS-CoV-2 phylodynamics analysis (virological)
    • Bat CoV surveillance in China (PLoS Path)
    • Image credit
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - Alejandro Sanchez TED Talk Vincent - WHO SARS-CoV-2 Sitrep

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    TWiEVO 51: The starting point paradox Jan 22, 2020

    Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material.

    Hosts: Nels Elde and Vincent Racaniello

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    • Primordial emergence of a nucleic acid binding protein (bioRxiv)
    • Tawfik laboratory
    • Image credit
    • Letters read on TWiEVO 51
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - Universal principled review Vincent - Hostile Planet by National Geographic

    Listener Pick

    Courtney - Nightwish Endless Forms Most Beautiful and Shudder Before The Beautiful

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    TWiEVO 50: I'm dreaming of a Y chromosome Dec 24, 2019

    Nels and Vincent discuss signatures of sex chromosome evolution revealed by assembly of a young vertebrate Y chromosome from 3-spined stickleback fish.

    Hosts: Nels Elde and Vincent Racaniello

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    • Assembly of a young vertebrate Y chromosome (bioRxiv)
    • Image credit
    • Letters read on TWiEVO 50
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - Genome from a 5,700-Year-Old Wad of Chewed Gum Vincent - NJ Sea-Level Rise Reports

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    TWiEVO 49: A giant podcast on giant viruses Nov 29, 2019

    Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Rich Condit

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    • Endless giant virus forms most beautiful (TWiV 575)
    • 4th Ringberg Giant Virus Meeting Program (pdf)
    • Photographs by Matthias Fischer
    • Time stamps by Jolene. Thanks!
    Science Picks

    Rich - Flightradar24 Nels - Deutsches Museum Munich Vincent - Diversify Microbiology

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    TWiEVO 48: Flipping out with choanos on caffeine Oct 31, 2019

    Nels and Vincent reveal a new choanoflagellate that forms multicellular cup shaped colonies that respond to light to alternate between feeding and swimming behavior.

    Hosts: Nels Elde and Vincent Racaniello

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    • Microbial accomplices in multicellularity (TWiEVO 11)
    • Light regulated collective contractility (Science)
    • Image credit
    • Letters read on TWiEVO 48
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - How to write a great science paper by Cormac McCarthy Vincent - Natural Selection Store

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    TWiEVO 47: On the origin of beer species Sep 19, 2019

    Nels and Vincent trace the origins of Saccharomyces cerevisiae strains used to make beer, and find that ales and lagers are made with yeasts that were derived from those used to make European grape wine and Asian rice wine.

    Hosts: Nels Elde and Vincent Racaniello

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    • Origins of beer yeasts (PLoS Biol)
    • Chateau Jiahu beer
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - Population fluctuations in 10 biggest cities Vincent - 1.7 million year old rhino tooth (original Nature paper)

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    TWiEVO 46: Can an old tumor teach us new tricks? Aug 31, 2019

    Nels and Vincent analyze the genomes of canine transmissible tumors to provide insight into the worldwide spread of the disease from its origin in a single dog 4000-8500 years ago, and its diversity, mutation, and evolution.

    Hosts: Nels Elde and Vincent Racaniello

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    • Evolution and mutation of canine transmissible cancer (Science)
    • Clam cancers (TWiEVO 17)
    • Sixth modality of infectious disease (PLoS Path)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels - Vasa Museum in Stockholm Vincent - Nobel Museum in Stockholm

    Listener Pick

    Irene - @EndlessFormsand #PlantScienceFascinatesMe #plantsday

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    TWiEVO 45: Microbial secrets of mouse-ear cress Jul 29, 2019

    At ASM Microbe in San Francisco, Nels and Vincent meet up with Talia Karasov who reveals that in contrast to agriculture, wild plants are colonized by multiple lineages of pathogenic bacteria.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Talia Karasov

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    • Talia Karasov in the Bergelson lab
    • Arabidopsis thaliana and Pseudomonas (Cell Host Micr)
    • Time stamps by Jolene. Thanks!

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    TWiEVO 44: The enemy of my enemy is my phage Jun 27, 2019

    At ASM Microbe in San Francisco, Nels and Vincent meet up with Paul Turner to talk about evolutionary considerations in using bacteriophages to treat infections with antibiotic-resistant bacteria.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Paul Taylor

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    • Turner Lab at Yale
    • Phage therapy: A renewed approach (Cell Host Microbe)
    • Phage treatment of aortic graft (Evol Med Pub Health)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels- Science Glass

    Vincent- Phage therapy for disseminated Mycobacterial infection

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    TWiEVO 43: Social evolution with a side of shrimp May 25, 2019

    Dustin Rubinstein joins Nels and Vincent to discuss coevolution of genome architecture and social behavior, and studying social transitions in sponge-dwelling snapping shrimp.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Dustin Rubinstein

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    • Co-evolution of genome architecture and social behavior (Trend Ecol Evol)
    • Social transitions in snapping shrimp (Curr Op Insect Sci)
    • Time stamps by Jolene. Thanks!
    Science Picks

    Dustin- Genesis: The Deep Origin of Societies 1 by E.O. Wilson, and The Human Swarm by Mark O. Moffett

    Nels- For Love of Insects by Thomas Eisner

    Vincent- Quacks blamed for Pakistan HIV-1 outbreak

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    TWiEVO 42: Who's who in your genome Apr 24, 2019

    Nels and Vincent review the contribution of multiple Denisovan lineages to the modern Papuan genome.

    Hosts: Nels Elde and Vincent Racaniello

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    • Denisovan ancestries in Papuans (Cell)
    • Prof Murray Cox
    • Image credit
    • Letters read on TWiEVO 42
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels- Sydney Brenner - What Genomes Can Tell Us About the PastVincent- Scientific Communication in a Post-Truth Society

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    TWiEVO 41: Where do baby genes come from? Mar 20, 2019

    Nels and Vincent explore the evolution of new protein-coding genes de novo from nocoding DNA sequences, using the antifreeze protein of northern codfish as a model.

    Hosts: Nels Elde and Vincent Racaniello

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    • Evolution of antifreeze protein gene in codfish (PNAS)
    • Codfish diversity (Cheng lab)
    • Frankentomatoes (Huff Post)
    • Image credit
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels- Science at Sundance reviews

    Vincent- The Rise and Fall of Scientific Authority

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    TWiEVO 40: Eau de bee Feb 15, 2019

    Nels and Vincent move back to reproductive isolation - this time, pre-zygotic, in the charismatic orchid bee where the males make chemically distinct perfumes to attract mates of the same species.

    Hosts: Nels Elde and Vincent Racaniello

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    • Olfactory receptor gene underlies reproductive isolation (biorXiv)
    • Image credit
    • Time stamps by Jolene. Thanks!
    Science Picks

    Nels- Nature Zen: Orchid Bees Are Shiny Vincent- What You Believe About Science Denial May Be All Wrong

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    TWiEVO 39: In a Legionella of their own Jan 26, 2019

    Nels and Vincent look at the intracellular bacteria Legionella from an evolutionary perspective: the role of gene acquisition and reshuffling from plants, animals, fungi, and archaea in the emergence of human pathogens.

    Hosts: Nels Elde and Vincent Racaniello

    Subscribe (free): iTunes, Google Podcasts, RSS, email

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    • Over 18,000 effectors in Legionella genome (PNAS)
    • Carmen Buchrieser lab
    • Howard Shuman
    Science Picks

    Nels - Science in Film (twitter) Vincent - Lunar Eclipse 101

    Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
    TWiEVO 38: Evolving to evolve Dec 24, 2018

    Nels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics.

    Hosts: Nels Elde and Vincent Racaniello

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    • Inhibiting evolution of antibiotic resistance (Mol Cell)
    • Pushing viruses over the error threshold (virology blog)
    • Image credit
    • Letters read on TWiEVO 38
    Science Picks

    Nels- Science/nature illustrator/artist Rachel Ignotofsky (website, Etsy shop) Vincent- Life Ascending by Nick Lane

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 37: A tangled tree on the Quammens Nov 17, 2018

    David Quammen joins Nels and Vincent to talk about his new book, A Tangled Tree, including evolutionary trees, Carl Woese, Lynn Margulis, horizontal gene transfer, and much more.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: David Quammen

    Subscribe (free): iTunes, Google Podcasts, RSS, email

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    • David's website
    • David on TWiV 408, Boston Quammens
    • Axel Erlandson's trees reimagined - Gilroy Gardens

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 36: All's not quiet on the telomeric front Oct 24, 2018

    Mia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophilahave evolved in conflict with the genome.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Mia Levine

    Subscribe (free): iTunes, Google Podcasts, RSS, email

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    • Levine Lab at U Penn
    • Telomere elongation without telomerase (bioRxiv)
    • Letters read on TWiEVO 36
    Science Picks

    Nels - Cinema Science podcast Vincent - Mastodon bones unearthed (Instagram, Grand Rapids News)

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 35: Strawberry sex chromosomes forever Sep 21, 2018

    Nels and Vincent reveal that female-specific DNA associated with sex in strawberries has repeatedly changed its genomic location, possibly linking new genes with sex.

    Hosts: Nels Elde and Vincent Racaniello

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    • Jumping sex genes in strawberries (PLoS Biol)
    • Red Queen by Matt Ridley
    • Image credit
    • Letters read on TWiEVO 35
    Science Picks

    Nels - New snailfish and Cloned crayfish Vincent -A PhD Lab Coat Ceremony

    Listener Picks

    Steve - Diversity in simple blobs Justin - On Growth and Forms by D'Arcy Wentworth Thompson

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    TWiEVO 34: You don’t know what you’ve got ‘til it’s PON Aug 16, 2018

    Nels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides.

    Hosts: Nels Elde and Vincent Racaniello

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    • Ancient lossesof paraoxonase I (Science)
    • Big Yellow Taxi (YouTube)
    • Image credit
    • Letters read on TWiEVO 34

    Hey farmer farmer put away the chlor-pyri-fus I don’t care about spots on my apples Leave me the manatee and walruses

    Science Picks

    Nels - New dinosaur discovered in Utah Vincent -The Song of the Dodo by David Quammen

    Music on TWiEVO is performed by Trampled by Turtles

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    TWiEVO 33: Fly by virus Jul 25, 2018

    Nels and Vincent are astounded by the finding of an insect-derived virus in a fungus that manipulates the behavior of flies.

    Hosts: Nels Elde and Vincent Racaniello

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    • Virus in fungus in fly (bioRxiv)
    • On a leaf, no one can hear you scream (TWiV 443)
    • Nels gives Benzer Lecture (YouTube)
    • Domestication of fungal fly pathogen (bioRxiv)
    • Sequencing E. muscae genome (10X genomics)
    • Eisen's twitter stream on new iflavirus (Twitter)
    Science Picks

    Nels - Mindsuckers; getting photos; Anand Varma photos Vincent - Happy Birthday Gregor Mendel

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 32: Never not neutral Jun 19, 2018

    Matt joins Nels and Vincent to discuss the neutral theory of evolution and its rejection in light of genome-scale data.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Matt Hahn

    Become a patron of TWiEVO

    • Hahn Lab
    • Molecular Population Genetics by Matt Hahn
    • Neutral theoryin light of natural selection (Mol Biol Evol)
    • Neutral Sequence Fallacy(Assembly of Fragments)
    • Splendor and miseryof adaptation (BMC Biol)
    • Image credit
    • Letters readon TWiEVO 32
    Science Picks

    Nels - Inaugural Transposon Day Vincent - How many human genes?

    Listener Pick

    Anne- Plants repeatedly lose ability to obtain nitrogen

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 31: Virus archaeology, or when the human genome is the junk May 19, 2018

    Nels and Vincent present ancient hepatitis B virus genome sequences from Bronze Age to Medieval period human remains.

    Hosts: Nels Elde and Vincent Racaniello

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    • Ancient hepatitis B virus genomes(Nature)
    • Even more ancient HBV genomes(bioRxiv)
    • Image credit
    • Letters readon TWiEVO 31
    Science Picks

    Nels - Sampling whale breathwith drones (Preprint) Vincent - Verge Science

    Music on TWiEVO is performed by Trampled by Turtles

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    TWiEVO 30: Driving Miss Maize-y Apr 21, 2018

    Nels and Vincent reveal how a motor protein in corn causes preferential transmission of chromosomes to egg cells, leading to non-Mendelian inheritance.

    Hosts: Nels Elde and Vincent Racaniello

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    • Molecular Evolution and the Cellmeeting
    • Selfishcorn chromosomes (Cell)
    • Dawe Lab- neocentromeres and meiotic drive
    • Image credit
    • Letters readon TWiEVO 30
    Science Picks

    Nels - Craypot stinkhorn mushroom (Colus pusilus) Vincent -Doubts raised over plan to release herpesvirus to wipe out carp

    Music on TWiEVO is performed by Trampled by Turtles

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    TWiEVO 29: Evolution on the wing Mar 21, 2018

    Nels and Vincent discuss the evolution of blood feeding to nonbiting in a mosquito, and evolution of bacterial virulence in the house finch caused by incomplete host immunity.

    Hosts: Nels Elde and Vincent Racaniello

    Become a patron of TWiEVO

    • Molecular Evolution and the Cell meeting
    • Mosquito evolution from blood feeding to nonbiting (PNAS)
    • Mosquito blood feeding is not a free lunch (virology blog)
    • Incomplete immunity and evolution of virulence (Science)
    • Image credit
    • Letters read on TWiEVO 29
    Science Picks

    Nels - IDEA and Impossible Foods Vincent - it is NOT junk

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 28: Genetics of skin pigmentation in Africa Feb 28, 2018

    Sarah Tishkoff joins Nels and Vincent to explain work from her laboratory on the genetic basis of skin pigmentation in Africans.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Sarah Tishkoff

    Become a patron of TWiEVO

    • Molecular Evolution and the Cell meeting
    • Sarah AMA on Reddit
    • Genetics of African skin pigmentation (Science)
    • Image credit
    Science Picks

    Nels - In Defense of Plants (Shrew Loo) Vincent - Contribution of NIH funding to new drug approvals

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 27: Coldevo Jan 13, 2018

    Taking a cue from the recent frigid weather, Nels and Vincent explore how modifications of a neuronal cold-sensing channel regulate diminished cold sensitivity in hibernating mammals.

    Hosts: Nels Elde and Vincent Racaniello

    Become a patron of TWiEVO

    • Why ground squirrels and hamsters don't mind the cold (Cell Rep)
    • Image credit
    • Letters read on TWiEVO 27
    Science Picks

    Nels - Undergrad podcasters from Stonehill College Vincent - Viruses at Target

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 26: My Scientist Vinny Dec 07, 2017

    Vinny Lynch joins Nels and Vincent to discuss how a zombie gene in elephants protects these large, long lived animals from cancer.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Vinny Lynch

    Become a patron of TWiEVO

    • Lynch Lab
    • Elephant zombie LIF gene induces apoptosis (bioRxiv)
    • Image credit
    Science Picks

    Nels - Animalism Vincent - Voyager I fires up thrusters after 37 years Vinny - Rollin' Wild

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 25: Pigeons show the way Nov 22, 2017

    Nels and Vincent discuss a genomic analysis of the passenger pigeon, which shows that species with large and stable populations may be at risk of extinction after a sudden environmental change.

    Hosts: Nels Elde and Vincent Racaniello

    Become a patron of TWiEVO

    • Passenger pigeon genomic diversity (Science)
    • Image credit
    • Letters read on TWiEVO 25
    Science Picks

    Nels - Video of nematophagous fungi Vincent - How should novelty be valued in science? John - Evo-Devo (Despacito Biology Parody) Melanie - What's in John's Freezer

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 24: Good viruses visiting bad neighborhoods Oct 26, 2017

    Marco Vignuzzi joins Nels and Vincent to discuss recent work from his laboratory on redirecting RNA virus evolution in sequence space.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Marco Vignuzzi

    Become a patron of TWiEVO

    • Vignuzzi Laboratory
    • Redirecting evolution of RNA viruses in sequence space (Nat Micro)
    • Is quasispecies concept relevant to RNA viruses? (J Virol)

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first order and free shipping by going to blueapron.com/twie.

    Science Picks

    Nels - Global Tagging of Pelagic Predators Vincent - Why has the EPA shifted on toxic chemicals? Marco - Labs of Siobain Duffy, Seema Lackdawala, Chris Brook

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 23: The Alus are going to be alright Sep 20, 2017

    Nels and Vincent reveal how the protein DHX9 suppresses RNA processing defects caused by invasion of the Alu retroelement into the human genome.

    Hosts: Nels Elde and Vincent Racaniello

    Become a patron of TWiEVO

    • DHX9 suppresses Alu defects (Nature)
    • Asifa Akhtar on The Latest Thinking

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Nels - Saving Hellbender Salamanders Vincent - The Living River

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 22: E pluribus cerevisiae Aug 30, 2017

    Maitreya Dunham joins Nels and Vincent to explain how her laboratory uses experimental evolution to study yeast flocculation, the community-building cell aggregation trait.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Maitreya Dunham

    Become a patron of TWiEVO

    • Dunham Laboratory
    • Adaptive Routes to Cell Aggregation in Yeast (Genetics)
    • Making the best of a sticky situation (SGD)
    • Yeast Genetics and Genomic Course (Cold Spring Harbor)
    • Genetic basis of biofilm formation (Beacon)
    • 2017 CSH Plate Race (YouTube)
    • Image credit

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Nels - Floating Fire Ant Colonies in Houston and Help for Houston Researchers Vincent - Help People Affected by Harvey and How To Help Harvey Victims

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 21: A virus with a green thumb Jul 13, 2017

    Rich Condit joins Nels and Vincent to explain how a vaccinia virus protein customizes ribosomes to favor the translation of viral mRNAs with a stretch of A residues in the 5'-untranslated region.

    Hosts: Nels Elde and Vincent Racaniello

    Become a patron of TWiEVO

    • Rich Condit with Harry Noller (scroll down)
    • Trans-Kingdom mimicry? (Nature)
    • More on RACK1 (Nat Struct Mol Biol)
    • Image credit
    • Letters read on TWiEVO 21

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Rich - Sniffing out significant “Pee values” Nels - Cuttlefish mimicking a hermit crab (evolutionary context) Vincent - Our first bioRxiv submission!

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 20: In the company of cnidarians Jun 20, 2017

    Nels and Vincent explore the role of TSR proteins during colonization of cnidarians by dinoflagellates.

    Hosts: Nels Elde and Vincent Racaniello

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    • TSR domain proteins in cnidarian-dinoflagellate symbiosis
    • A. elegantissima image credit
    • Letters read on TWiEVO 20
    Science Picks

    Nels - CRISPR 5 ways Vincent - The Vital Question by Nick Lane

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 19: The beauty of the story May 24, 2017

    Jonathan Weiner, author of the Pulitzer Prize-winning Beak of the Finch, joins Nels and Vincent to talk about his career and his writing.

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Jonathan Weiner

    Become a patron of TWiEVO

    • Jonathan's Columbia University page
    • Jonathan's author page
    Science Picks

    Nels - The Gap by Ira Glass Vincent - EPA removes climate science site

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 18: Raiders of the lost orco Apr 10, 2017

    Hosts: Nels Elde and Vincent Racaniello

    Guests: Ni-Chen 'Sylvia' Chang, Waring 'Buck' Trible, and Sean K. McKenzie

    Buck and Sean join Vincent in New York, while Sylvia is with Nels in Salt Lake City to discuss the first mutant ant ever made: disruption of orco, a gene required for function of odorant receptors, show defects in social behavior and fitness.

    Become a patron of TWiEVO

    • First ant mutants link odorant receptors and social behavior (bioRxiv)
    • Kronauer Lab

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Nels - Urban Nature and What Makes a City Ant? Vincent - Animations from WEHI

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 17: The curious cases of clam cancers Mar 13, 2017

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Stephen Goff

    Nels joins Vincent in New York City to speak with Stephen Goff about transmissible clam cancers and the silencing of integrated retroviral genomes.

    Become a patron of TWiEVO

    • A sixth modality of infectious disease (PLoS Path)
    • Horizontal transmission of clam cancer (Cell)
    • Transmissible bivalve cancers (Nature)
    • Retrovirus transcriptional silencing (J Virol)
    • Histones on retroviral DNA (Cell Host Micr)
    • Image credit

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Nels - Mindsuckers Vincent - What is a species?

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 16: Breaking in the making of genes Feb 25, 2017

    Hosts: Nels Elde and Vincent Racaniello

    Nels and Vincent reveal how introns - the parts of pre-mRNAs that are removed by splicing - were generated by DNA transposons in two different picoeukaryotes.

    Become a patron of TWiEVO

    • Introns from DNA transposons (Nature)
    • Reverse transcription and integration lecture
    • Image: Elde Lab Mobile Studios on location in Santa Fe, NM
    • Letters read on TWiEVO 16

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Nels - Did eukaryotes invent anything? (TWiM 144) Vincent - Virology course online

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 15: From cockroaches to grizzly bears Jan 22, 2017

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Hopi Hoekstra

    Nels and Vincent speak with Hopi Hoekstra about her career and the work of her laboratory on developmental mechanisms of stripe patterns in rodents.

    Become a patron of TWiEVO

    • Hoekstra Laboratory
    • Hopi on Twitter
    • Mechanisms of stripe patterns in rodents (Nature)
    • Image credit
    • Letters read on TWiEVO 15

    This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twie.

    Science Picks

    Hopi -Diversify EEB, Anne's List Nels - Celebration for Harry Noller Vincent - Biological Warfare, Virus Style (journal article)

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 14: TWi-light on the Wasatch Front Dec 22, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Guests: Jessica Brown, Michael Kay, Wayne Potts, June Round, and Janis Weis

    From the Microbial Pathogenesis Retreat of the University of Utah School of Medicine, held at the Utah Museum of Natural History, Nels and Vincent speak with faculty members about their work on bacteria, fungi, viruses, and mirror-image biochemistry.

    Watch video of this episode at YouTube

    Become a patron of TWiEVO

    This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

    Science Picks

    Nels - An Open Letter to My Class Vincent - The Beak of the Finch by Jonathan Weiner

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 13: This week in ants Nov 16, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Corrie Moreau

    Corrie joins Nels and Vincent to talk about her comparative analysis of the genomes of mutualist ants that nest in plants, and non-symbiotic species.

    Become a patron of TWiEVO

    Links for this episode
    • Moreau Laboratory
    • Different rates of evolution in ant-plant mutualisms (Nat Commun)
    • Image credit

    This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

    Science Picks

    Nels - Mind-melting animated gifs Vincent - Parasites Without BordersCorrie - Brain Scoop with Emily Graslie

    Listener Pick

    Chris - Shark weapons

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 12: Take a left at the goats Oct 19, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Josh Drew

    Josh joins Nels and Vincent to talk about his research on the evolution and conservation of aquatic tropical biodiversity, and the historical ecology of 19th century American Whalers.

    Become a patron of TWiEVO

    Links for this episode
    • Drew Laboratory at Columbia University
    • American Whalers by Ed Yong
    • Karen Bao
    • Sea cucumber genome
    • Sea cucumber population connectivity (Nature)

    This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

    This episode is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more.

    Science Picks

    Nels - Dr. Mary-Claire King at World Science Festival Vincent - Contagious ThinkingJosh - Diversify EEB

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 11: Microbial accomplices in multicellularity Sep 27, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Nicole King

    Nicole joins Nels and Vincent to discuss the finding of her laboratory that multicellular development of choanoflagellates, the closest living relatives of animals, is regulated by bacterial lipids.

    Become a patron of TWiEVO

    Links for this episode
    • Nicole King on Twitter
    • Choanoflagellate workshop
    • Bacterial lipids regulate Salpingoeca development (PNAS)
    • Image credit
    • Letters read on TWiEVO 11

    This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

    This episode is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more.

    Science Picks

    Nels - I Contain Multitudes by Ed Yong (Fresh Air interview) Vincent - Viral Infections of Leisure by David Schlossberg

    Listener Pick

    Justin - Endless Forms Most Beautiful by Sean B. Carroll

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    TWiEVO 10: Spicing up peppered moths with a selfish gene Aug 13, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Nels and Vincent review experiments showing that the replacement of a pale moth with a black one during the industrial revolution was caused by a transposable element.

    Links for this episode
    • Last experiment of Michael Majerus (Biol Lett)
    • Moth melanism mutation is transposon (Nature)
    • Image credit
    • Letters read on TWiEVO 10
    Science Picks

    Nels - Is Pokémon Go good for science? (one, two, three) Vincent - Seven Brief Lessons on Physics by Carlo Rovelli

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    Become a patron of TWiEVO

    TWiEVO 9: How to crash your gene drive Jul 05, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Jim Bull

    Nels and Vincent speak with Jim Bull about the results of genetic models which suggest that the evolution of inbreeding in response to lethal gene drive might make population control difficult to achieve.

    Links for this episode
    • Lethal gene drive selects inbreeding (bioRxiv)
    • Panel endorses gene drive technology (NY Times)
    • Genes in Conflict by Austin Burt
    • Letters read on TWiEVO 9
    Science Picks

    Nels - Fertilization with parasitic sperm Vincent - Undark

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    Become a patron of TWiEVO

    TWiEVO 8: Everyone's a little bit Neanderthal Jun 08, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Nels visits Vincent in the MicrobeTV studio in New York and talks about how key genes of the Homo sapiens innate immune response were acquired from Neanderthals.

    Links for this episode
    • Introgressed Neanderthal haplotype at OAS locus (biorXiv)
    • Genetic time travel (Genetics)
    • Genetic history of Ice Age Europe (Nature)
    • Letters read on TWiEVO 8
    Science Picks

    Nels - DNA Clues to our Inner Neanderthal Vincent - Blockhead

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

    Become a patron of TWiEVO

    TWiEVO 7: Pigeon fashion week, feathery boots edition Apr 23, 2016

    Hosts: Nels Elde and Vincent Racaniello

    Guest: Mike Shapiro

    Mike joins Nels and Vincent to talk about his work on what controls whether pigeons have scaly or feathered feet, and reveals that the hindlimbs of domestic birds with feathery feet are more like wings at the molecular level.

    Links for this episode
    • Shapiro Laboratory
    • Shifts in limb identity underlie development of feathered feet (eLife)
    • Photo of Muffed Fairy Swallow by Sydney Stringham
    Science Picks

    Mike - Pigeon exhibit, Natural History Museum of Utah; Pigeonetics (App store); Darwin's PigeonsNels - National Parasite CollectionVincent - The Story Collider

    Music on TWiEVO is performed by Trampled by Turtles

    Send your evolution questions and comments to twievo@microbe.tv

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