This Week in Cardiology

Nov 15 2024 This Week in Cardiology Nov 15, 2024

Tirzepatide, AF screening, and an AHA preview, including VT ablation, LAAC at the time of AF ablation, BP targets, and GLP1 agonists in HF are the topics John Mandrola, MD, covers in today's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Tirzepatide

SURMOUNT 1 – Three-year results https://www.nejm.org/doi/full/10.1056/NEJMoa2410819

II. AF Screening

GUARD AF https://www.jacc.org/doi/10.1016/j.jacc.2024.08.019
LOOP 10.1016/S0140-6736(21)01698-6
STROKE STOP 10.1016/S0140-6736(21)01637-8

III. LAAC with AF ablation

Mandrola Previews the OPTION Trial, the Most Worrisome Study at AHA 2024

https://www.medscape.com/viewarticle/mandrola-previews-option-trial-most-worrisome-study-aha-2024-2024a1000kmz

The OPTION Trial Rationale https://doi.org/10.1016/j.ahj.2022.05.003

IV. Blood Pressure Targets

BPROAD https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13411
ACCORD - https://www.nejm.org/doi/full/10.1056/NEJMoa1001286

V. GLP1a for HFpEF

SUMMIT at Clinicaltrials.gov https://clinicaltrials.gov/study/NCT04847557

VI. VT Ablation

VANISH2 Rationale https://doi.org/10.1016/j.ahj.2024.04.009
VANISH 1 https://www.nejm.org/doi/full/10.1056/NEJMoa1513614

VII. Spironolactone Results of CLEAR-SYNERGY

Nov 08, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1001865

'No Hint of Benefit' in Large Colchicine Trial

https://www.medscape.com/viewarticle/no-hint-benefit-large-colchicine-trial-2024a1000ko4

CLEAR SYNERGY Rationale https://pubmed.ncbi.nlm.nih.gov/38936755/

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Nov 08 2024 This Week in Cardiology Nov 08, 2024

The EARLY TAVR trial, colchicine after MI, and the TRISCEND II trial of tricuspid valve replacement are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Early TAVR

EARLY TAVR https://www.acc.org/latest-in-cardiology/clinical-trials/2024/10/24/14/42/early-tavr
Rationale https://doi.org/10.1016/j.ahj.2023.11.019
AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639
RECOVERY https://www.nejm.org/doi/full/10.1056/NEJMoa1912846
FAME 2 https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
Rajkumar; Faith Healing in Unblinded Trials https://pubmed.ncbi.nlm.nih.gov/29530888/
PARTNER 3 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307447
EARLY TAVR: A Positive Trial That Fails to Inform Clinical Decisions https://www.medscape.com/viewarticle/early-tavr-positive-trial-fails-inform-clinical-decisions-2024a1000kec

II. Colchicine

Meta-analysis https://doi.org/10.1016/j.eclinm.2024.102835
Clear-Synergy Rationale https://pubmed.ncbi.nlm.nih.gov/38936755/
COLCOT (post MI) https://www.nejm.org/doi/full/10.1056/NEJMoa1912388
LoDoCo (Chronic CAD) https://www.nejm.org/doi/full/10.1056/NEJMoa2021372

III. TRISCEND II Trial

TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918

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Oct 25 2024 This Week in Cardiology Oct 25, 2024

Listener feedback on PFA and STEMI/NSTEMI paradigm, oral semaglutide, symptomatic vs asymptomatic AF, and the win-ratio are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Listener Feedback

Oct 18, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1001769

Pulsed Field Ablation

https://www.hrsonline.org/guidance/safety-alerts/boston-scientific-cardiac-cryoablation-system

STEMI/NSTEMI https://doi.org/10.1016/j.jacadv.2024.101314

II. Oral Semaglutide

Press Release: https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=171480
Rationale Paper SOUL trial

III. Symptomatic vs Asymptomatic AF

Meta-analysis in EHJ
Meta-analysis of rate vs rhythm-control strategies https://doi.org/10.1016/j.jacep.2024.03.006

IV. The Win Ratio

Pocock and colleagues https://doi.org/10.1093/eurheartj/ehae647

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Oct 18 2024 This Week in Cardiology Oct 18, 2024

Listener feedback on the c-statistic, atherosclerotic plaque imaging, WATCHMAN implant decisions in the US, and deprescribing are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I.Listener Feedback

Oct 11, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1001735

Nancy Cook; C-statistic https://doi.org/10.1161/CIRCULATIONAHA.106.672402

II. Plaque Imaging

New Evidence That Plaque Buildup Shouldn't Be Ignored

https://www.medscape.com/viewarticle/new-evidence-plaque-buildup-shouldnt-be-ignored-2024a1000ihw

Fuster and colleagues; Imaging vs CAC

III. WATCHMAN Decisions

Zeitler and colleagues. Long-term Outcomes

IV. Deprescribing

Cognitive Decline and Antihypertensive Use: New Data

https://www.medscape.com/viewarticle/cognitive-decline-and-antihypertensive-use-new-data-2024a1000isw?form=fpf

Jing and colleagues.

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Oct 11 2024 This Week in Cardiology Oct 11, 2024

Reader feedback on cardiac devices and PFA, a new paradigm in the language of MI, sudden cardiac death, and measuring blood pressure are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Listener Feedback

Sep 20, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1001631

Cardiac Devices

https://www.acpjournals.org/doi/10.7326/ANNALS-24-00724

Impact of PFA on Intraluminal Esophageal Temperature https://onlinelibrary.wiley.com/doi/10.1111/jce.16096

II. Towards a New Classification of MI

McLaren and colleagues; From STEMI to OMI https://doi.org/10.1016/j.jacadv.2024.101314

III. Sudden Death After MI.

EHJ Paper; SCD After MI https://doi.org/10.1093/eurheartj/ehae326
Barsheshet and colleagues; Risk Score to Predict Benefit of ICD https://doi.org/10.1016/j.jacc.2012.02.036
Zegard and colleagues; Myocardial Fibrosis and SCD 10.1016/j.jacc.2020.10.046
MADIT RIT https://www.nejm.org/doi/full/10.1056/NEJMoa1211107

IV. BP Readings

Poor Arm Position May Significantly Skew BP Readings

https://www.medscape.com/viewarticle/poor-arm-position-may-significantly-skew-bp-readings-2024a1000icv?form=fpf

ARMS Crossover RCT

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Oct 04 2024 This Week in Cardiology Oct 04, 2024

Reader feedback on LGE pre-ICDs, PFA for AF ablation, CTO-PCI, endovascular ablation of the greater splanchnic nerve in HFpEF, and data sharing are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Listener Feedback

Sept 27, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1001666

JAMA Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2823869/

II. Pulsed Field Ablation for AF

Feb 02, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/999995

ADMIRE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.070333
ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291

III. PCI for CTO

EuroCTO One Year SAQ Results https://doi.org/10.1093/eurheartj/ehy220
EuroCTO Hard Outcomes https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions
Faith Healing and Subtraction Anxiety https://doi.org/10.1161/CIRCOUTCOMES.118.004665
DECISION CTO trial https://doi.org/10.1161/CIRCULATIONAHA.118.031313
ISCHEMIA CTO Rationale and Design https://doi.org/10.1016/j.ahj.2022.11.016

IV. Greater Splanchnic Nerve Ablation for HFpEF

REBALANCE HF https://jamanetwork.com/journals/jamacardiology/fullarticle/2823999

V. Data Sharing

The Pros and Cons of Clinical Trial Data Sharing

https://www.medscape.com/viewarticle/862815

Kramer and Nallamothu, Caution in Data Sharing https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.124.010257
Nosek, Variability in Analytic Methods https://journals.sagepub.com/doi/10.1177/2515245917747646
Zeraatker, Variability in Analytic Methods

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Sep 27 2024 This Week in Cardiology Sep 27, 2024

Surgical clearance, NICM assessment, dueling perspectives on PCI as first-line therapy for angina, GDMT in HFrEF are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. New ACC Peri-operative Guidelines Released

ACC Guideline document https://www.jacc.org/doi/10.1016/j.jacc.2024.06.013
J Vasc Surg https://www.jvascsurg.org/article/S0741-5214(21)00335-9/fulltext
McFalls and colleagues; CARP https://www.nejm.org/doi/full/10.1056/NEJMoa041905

II. NICM – We may be doing it wrong in Selecting ICDs

JAMA Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2823869/
German CMR ICD Trial https://www.clinicaltrials.gov/study/NCT04558723
BRITISH CMR trial https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/britishusing-cmr-scar-as-risk-indication-tool-in-nicm-and-severe-lvsd/

III. When Should PCI be Used in Chronic Stable CAD?

Rajkumar and Al-Lamee; PCI First https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.124.011201

Boden and De Caterina; Meds First https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.124.011268
ORBITA 10.1016/S0140-6736(17)32714-9
ORBITA 2 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2310610

IV. GDMT Underuse in HFrEF

Greene and colleagues https://doi.org/10.1016/j.jchf.2024.08.002
DAPA HF https://www.nejm.org/doi/full/10.1056/NEJMoa1911303
RALES https://www.nejm.org/doi/full/10.1056/NEJM199909023411001

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Sep 20 2024 This Week in Cardiology Sep 20, 2024

Listener feedback, K levels post cardiac surgery, cardiac device safety, disparities in preventive care, stopping trials early, and a SHAM-PVI update are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Listener Feedback

Sep 13, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1001596

Sripal Bangalore Tweet on Yusef Meta-analysis https://x.com/SripalBangalore/status/1750116964893094125

II. Post Cardiac Surgery AF

TIGHT K Trial https://jamanetwork.com/journals/jama/fullarticle/2823246

III. Evidence Base for New Cardiac Devices

Annals of IM Survey Observational Study https://www.acpjournals.org/doi/10.7326/ANNALS-24-00724

IV. Disparities in Care

JAMA Network Open Paper on Insurer Denials of Preventive Care https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823677

V. Stopping Trials Early

Kaul and Butler; Insights on Recent CKD Trials https://doi.org/10.1016/j.jacc.2024.07.026
Bassler Systematic Review https://jamanetwork.com/journals/jama/fullarticle/185591

VI. Sham PVI

AF Ablation Works…But: The Positive SHAM-PVI Trial

https://www.medscape.com/viewarticle/af-ablation-works-positive-sham-pvi-trial-2024a1000gzl?&icd=login_success_email_match_fpf

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Sep 13 2024 This Week in Cardiology Sep 13, 2024

More from ESC: the SCOFF trial and fasting before cardiac cath, MATTERHORN, humbling data with AI, plus a reflection on the work of being a patient are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Fasting Before Cardiac Procedures

The SCOFF Trial https://doi.org/10.1093/eurheartj/ehae573

II. MV repair for Functional MR

Large Trials Support Mitral Valve Repair in Heart Failure

MATTERHORN https://www.nejm.org/doi/full/10.1056/NEJMoa2408739

III. AI in Medicine

Rapidx AI Project https://healthtranslationsa.org.au/project/rapid-x-ai/
PROTEUS Trial Rationale paper https://pubmed.ncbi.nlm.nih.gov/37192698/

IV. Time Toxicity

Time Toxicity https://link.springer.com/article/10.1007/s00520-024-08844-1
Thread X https://x.com/EnriqueSoto8/status/1833587144256065859

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Sep 06 2024 This Week in Cardiology Sep 06, 2024

Feedback on ABYSS and beta-blockers, more ESC recap, including SHAM-PVI, FINEARTS-HF, and RESHAPE HF2 trials are the topics John Mandrola, MD, discusses in today’s podcast.

This podcast is intended for healthcare professionals only.

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I. Feedback on ABYSS

Setbacks After Stopping Beta-Blockers

https://www.medscape.com/viewarticle/setbacks-after-stopping-beta-blockers-2024a1000fv7

Beta-Blockers Post-MI? No for Me, Even After the ABYSS Trial

https://www.medscape.com/viewarticle/beta-blockers-post-mi-no-me-even-after-abyss-trial-2024a1000fva

ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
REDUCE AMI https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
QOL paper REDUCE AMI https://doi.org/10.1093/ehjcvp/pvae062
Atenolol ED paper 10.1016/j.ehj.2003.08.016

II. SHAM-PVI

JAMA SHAM-PVI paper https://jamanetwork.com/journals/jama/article-abstract/2823283
Gupta QOL paper https://pubmed.ncbi.nlm.nih.gov/33952593/

III. FINEARTS HF

Finerenone Benefits Heart Failure With Preserved EF

https://www.medscape.com/viewarticle/finerenone-benefits-heart-failure-preserved-ef-2024a1000fza

Topline Finerenone Results Point to Advance in Heart Failure

https://www.medscape.com/viewarticle/topline-finerenone-results-point-advance-heart-failure-2024a1000fq2

FINEHEARTS -HF NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
FIDELIO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2025845
FIGARO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2110956
Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? https://doi.org/10.1016/j.jacc.2024.08.033

IV. RESHAPE HF

TEER in Functional MR: Data Deluge, but No Easy Answers

https://www.medscape.com/viewarticle/teer-functional-mr-data-deluge-no-easy-answers-2024a1000fvg

Mitra FR https://www.nejm.org/doi/full/10.1056/NEJMoa1805374
COAPT https://www.nejm.org/doi/full/10.1056/NEJMoa1806640
RESHAPE- HF2 https://www.nejm.org/doi/full/10.1056/NEJMoa2314328
RESHAPE Subgroup paper https://doi.org/10.1016/j.jacc.2024.08.027

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Aug 30 2024 This Week in Cardiology Aug 30, 2024

From ESC: post-MI beta blockers, a new therapy for ATTR-CM, holding RASi before non-cardiac surgery, good news in HFpEF, and an ESC preview are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. ABYSS

ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
REDUCE AMI https://www.nejm.org/doi/full/10.1056/NEJMoa2401479

II. ATTR -CM HELIOS B

Positive Top Line Results for Vutrisiran in Cardiac Amyloidosis

https://www.medscape.com/viewarticle/positive-top-line-results-vutrisiran-cardiac-amyloidosis-2024a1000cjj

HELIOS A https://www.tandfonline.com/doi/full/10.1080/13506129.2022.2091985
HELIOS B https://www.nejm.org/doi/full/10.1056/NEJMoa2409134

III. STOP or NOT Trial

Observational Study Showing Benefits of Holding RASi https://doi.org/10.1097/ALN.0000000000001404
STOP or NOT Protocol Paper -- https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3247-1
JAMA STOP or NOT https://jamanetwork.com/journals/jama/fullarticle/2823118

IV. GLP1a in HFpEF

The GLP-1 Agonist Semaglutide in HFpEF Cleared a Low Bar https://www.medscape.com/viewarticle/995872

STEP-HFpEF https://www.nejm.org/doi/full/10.1056/NEJMoa2306963
STEP-HFpEF-DM https://www.nejm.org/doi/full/10.1056/NEJMoa2313917
SELECT https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
FLOW https://www.nejm.org/doi/full/10.1056/NEJMoa2403347
Lancet Meta-analysis https://doi.org/10.1016/S0140-6736(24)01643-X

V. ESC Preview

Mandrola's Five Big Trials to Look for at ESC 2024

https://www.medscape.com/viewarticle/mandrolas-five-big-trials-look-esc-2024-2024a1000fkt

Topline Finerenone Results Point to Advance in Heart Failure

https://www.medscape.com/viewarticle/topline-finerenone-results-point-advance-heart-failure-2024a1000fq2

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Aug 23 2024 This Week in Cardiology Aug 23, 2024

Suicidal ideation and GLP-1 agonists, a repeat of PARADIGM HF in Chagas CM, CASTLE HTx critical appraisal, and primary prevention of SCD in HF are the topics John Mandrola, MD, covers this week.

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I. Suicidal ideation with GLP-1

Signal of Suicidality With GLP-1 RA Semaglutide, but Experts Urge Caution

https://www.medscape.com/viewarticle/signal-suicidality-glp-1-ra-semaglutide-experts-urge-caution-2024a1000fa7

Disproportionality Analysis from World Health Organization Data on Semaglutide, Liraglutide, and Suicidality
Variability in Disproportionality paper https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.668765/full

II. PARACHUTE HF: Repeating the Mistakes in PARADIGM HF

PARACHUTE HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021
SOLVD https://www.nejm.org/doi/full/10.1056/NEJM199108013250501
CONSENSUS trial https://www.nejm.org/doi/full/10.1056/NEJM198706043162301
Meta-analysis of Low vs High Dose ACE/ARB https://doi.org/10.1161/CIRCHEARTFAILURE.117.003956
Meta-analysis of Sac/Val vs ARB/ACE Inhibitors https://link.springer.com/article/10.1007/s00228-024-03686-6
PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508

III. CASTLE HTx Critical Appraisal

Critical Appraisal of CASTLE HTx https://doi.org/10.1016/j.jacc.2024.06.020
CASTLE HTx https://www.nejm.org/doi/10.1056/NEJMoa2306037
CASTLE AF https://www.nejm.org/doi/full/10.1056/NEJMoa1707855

IV. More Data Suggesting Modest Benefits of the Primary Prevention ICD

First and Recurrent ICD Shocks: JICE Paper from Denmark https://link.springer.com/article/10.1007/s10840-024-01873-0
HF trialists https://www.nejm.org/doi/full/10.1056/NEJMoa1609758 PROFID Trial https://profid-project.eu/
DANISH https://www.nejm.org/doi/full/10.1056/NEJMoa1608029
SCD-HeFT https://www.nejm.org/doi/full/10.1056/NEJMoa043399

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Aug 16 2024 This Week in Cardiology Aug 16, 2024

Diuretic therapy in HFrEF, AF ablation, TACT 2 and the story of subgroups, and SGLT2 inhibitor underuse are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

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I. Diuretic Therapy in HF

Dapa vs Metolazone Trial https://doi.org/10.1093/eurheartj/ehad341 ADVOR https://www.nejm.org/doi/10.1056/NEJMoa2203094

II. Rapid Medication Titration for Acute HF

ACC Decision Pathway https://www.jacc.org/doi/10.1016/j.jacc.2024.06.002

III. SGLT2 Inhibitor Use in the US

Shin and Colleagues; JACC https://www.sciencedirect.com/science/article/abs/pii/S0735109724076332
Editorial https://doi.org/10.1016/j.jacc.2024.07.001

IV. AF Ablation: General Anesthesia vs Conscious Sedation

Da Riis-Vestergaard and Colleagues https://doi.org/10.1093/europace/euae203

V. TACT 2 Published

TACT 1 https://jamanetwork.com/journals/jama/fullarticle/1672238
TACT 1 DM https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.113.000663
TACT 2 https://jamanetwork.com/journals/jama/fullarticle/2822472

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Aug 09 2024 This Week in Cardiology Aug 09, 2024

Prediction models vs clinical judgement, CCTA quantification of atherosclerosis, AF ablation plus LAAO, atrial shunt devices, and HF medical therapy are topics John Mandrola, MD, covers this week.

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I.Clinical Prediction Models vs Clinical Judgement

Did Statin Decision-Making Just Get Harder?

https://www.medscape.com/viewarticle/did-statin-decision-making-just-get-harder-2024a1000egl

Colunga-Lozano and colleagues
https://doi.org/10.1016/j.jclinepi.2023.10.016
Aug 02, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001429

II. CCTA Quantification of Atherosclerosis

Atherosclerosis Quantification and Cardiovascular Risk: the ISCHEMIA Trial https://doi.org/10.1093/eurheartj/ehae471
Circulation ISCHEMIA sub study 2021 – Severity of CAD and Outcomes https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.049755
ISCHEMIA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1915922

III. Combined AF Ablation and LAAO

Review from Mills and colleagues https://doi.org/10.1016/j.tcm.2023.11.003
Link to CMS Rule on AF Ablation and LAAO https://hrs2.informz.net/z/cjUucD9taT05MjU3ODgyJnA9MSZ1PTkwMDQ2MTk4MCZsaT04NTU1OTQxMg/index.html

IV. Atrial Shunt Devices

No Net HF Benefit for Interatrial Shunt Device

https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk

Original REDUCE-LAP-HF-II https://doi.org/10.1016/S0140-6736(22)00016-2
Two-year results of REDUCE-LAP-HF-II https://doi.org/10.1016/j.jchf.2024.04.011
Apr 19, 2024 This Week in Cardiology Podcast

V. Optimal HF Therapy

Rao and colleagues; CHAMP HF https://doi.org/10.1016/j.jchf.2024.05.026

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Aug 02 2024 This Week in Cardiology Aug 02, 2024

Two downsides of PFA including autonomic tone and hemolysis, a bad surrogate in AF care, and controversies in defining cardiac risk are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I.PFA and Its (lack of) Effect on Autonomic Tone

Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?

https://www.medscape.com/viewarticle/pulsed-field-ablation-af-are-us-electrophysiologists-too-2024a1000d2v

Autonomic Tone Paper https://doi.org/10.1016/j.jacep.2024.05.005
ADVENT https://www.nejm.org/doi/full/10.1056/NEJMoa2307291

II. Second PFA Study JACC-EP—on Hemolysis

Hemolysis study https://doi.org/10.1016/j.jacep.2024.05.001
MANIFEST 17K https://www.nature.com/articles/s41591-024-03114-3
Defaye Editorial https://www.jacc.org/doi/abs/10.1016/j.jacep.2024.06.007

III. A Self-serving Surrogate Marker: Diagnosis to Ablation Time.

CAPLA Study https://jamanetwork.com/journals/jama/fullarticle/2800186
CAPLA Substudy https://doi.org/10.1016/j.jacep.2024.05.031
EHJ RCT Early vs Late https://doi.org/10.1093/eurheartj/ehad247
LOOP; Diederichsen and colleagues 10.1016/j.jacc.2019.09.050
Groningen and Maastricht Group study https://heart.bmj.com/content/109/3/186

IV. Future Cardiac Risk

Diao and colleagues Study of AHA PREVENT Risk Equations https://jamanetwork.com/journals/jama/fullarticle/2821624
JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821542
Another JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821628

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Jul 26, 2024 This Week in Cardiology Podcast Jul 26, 2024

Health and income, high BP in the hospital, and more on subclinical AF and when to use anticoagulants are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Health and Income

A Cash Giveaway to Improve Health

https://www.medscape.com/viewarticle/cash-giveaway-improve-health-2024a1000dhf?form=fpf

JAMA RCT https://jamanetwork.com/journals/jama/fullarticle/2821454
NBER RCT https://www.nber.org/papers/w32711
Have We Missed the Hidden Cause of Medical Overuse? https://www.medscape.com/viewarticle/908309
Mar 17, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/989775

Other References

Health Care Access and Management of Cardiovascular Risk Factors Among Working-Age Adults With Low Income by State Medicaid Expansion Status https://jamanetwork.com/journals/jamacardiology/article-abstract/2793120
Rand Link https://www.rand.org/pubs/reports/R3055.html
The Oregon Health Insurance Experiment https://www.healthaffairs.org/do/10.1377/hpb20150716.236899/full/
Effect of Health Insurance in India: A Randomized Controlled Trial https://www.nber.org/papers/w29576
Full Coverage for Preventive Medications after Myocardial Infarction https://www.nejm.org/doi/full/10.1056/nejmsa1107913
Effect of Medication Co-payment Vouchers on P2Y12 Inhibitor Use and Major Adverse Cardiovascular Events Among Patients With Myocardial InfarctionThe ARTEMIS Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2720024

II. Elevated BP in the hospital

JAMA-IM https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2821364

III. Short-duration Subclinical AF

Apixaban Cuts Stroke but Ups Bleeding in Subclinical AF: ARTESIA

https://www.medscape.com/viewarticle/998379

ARTESiA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
ARTESiA CHADSVASC Subgroup https://www.jacc.org/doi/10.1016/j.jacc.2024.05.002
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
EHJ NOAH subanalysis https://doi.org/10.1093/eurheartj/ehae225
Stroke: Prolonged Heart Rhythm Monitoring After Stroke https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045843
EHRA Analysis https://esc365.escardio.org/EHRA-Congress/sessions/10668

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Jul 19 2024 This Week in Cardiology Jul 19, 2024

Vulnerable plaque and scientific method; industry payments to trainees; tirzepatide or semaglutide; trial interpretation; and PFA are the topics John Mandrola, MD, covers in today’s podcast.

This podcast is intended for healthcare professionals only.

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I. Non-invasive Imaging for Vulnerable Plaque

PET Imaging Finds Vulnerable Plaques That Cause MI

https://www.medscape.com/viewarticle/pet-imaging-finds-vulnerable-plaques-cause-mi-2024a1000cm2

JACC paper https://doi.org/10.1016/j.jacc.2024.03.419
Original JAMA-Card paper https://jamanetwork.com/journals/jamacardiology/fullarticle/2806690

II. Industry Payments to Fellows

JAMA Network Letter https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2821267

III. GLP-1a Class Effect?

Semaglutide Significantly Improves Chronic Kidney Disease

https://www.medscape.com/viewarticle/semaglutide-significantly-improves-chronic-kidney-disease-2024a10009w9

Mounjaro Beats Ozempic, So Why Isn’t It More Popular?

https://www.medscape.com/viewarticle/mounjaro-beats-ozempic-so-why-isnt-it-more-popular-2024a1000ckd

JAMA-Internal Medicine: Semaglutide vs Tirzepatide https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2821080
SELECT trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
FLOW trial https://www.nejm.org/doi/full/10.1056/NEJMoa2403347
SURPASS-CVOT – Rationale https://doi.org/10.1016/j.ahj.2023.09.007

IV. Colchicine and Trial Interpretation in the Lancet

CONVINCE https://doi.org/10.1016/S0140-6736(24)00968-1

V. PFA

Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?

https://www.medscape.com/viewarticle/pulsed-field-ablation-af-are-us-electrophysiologists-too-2024a1000d2v

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Jul 12 2024 This Week in Cardiology Jul 12, 2024

Venous closure devices, GLP1-s linked to blindness and cancer, resisting the urge to do an ECG, and transcatheter edge-to-edge repair (TEER) for secondary mitral regurgitation are the topics discussed this week.

This podcast is intended for healthcare professionals only.

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I Listener Feedback

Venous vascular closure system vs. figure-of-eight suture following atrial fibrillation ablation: the STYLE-AF Study https://doi.org/10.1093/europace/euae105

II GLP1-s and Blindness

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2820255
Locke Twitter https://x.com/doc_BLocke/status/1808972226655629610
When to Start a Statin Is a Preference-Sensitive Decision https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808

III GLP1-s and Cancer

Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820833

IV Screening ECG

Routine Electrocardiogram Screening and Cardiovascular Disease Events in Adultshttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2820721
Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP) https://doi.org/10.1016/S0140-6736(21)01637-8
Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study) https://doi.org/10.1016/S0140-6736(21)01698-6

IV TEER for Secondary Mitral Regurgitation

Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE-HF2 trial design https://doi.org/10.1002/ejhf.3247
Percutaneous repair of moderate-to-severe or severe functional mitral regurgitation in patients with symptomatic heart failure: Baseline characteristics of patients in the RESHAPE-HF2 trial and comparison to COAPT and MITRA-FR trials https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3286
Jun 21, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001237
Stats Blog https://www.r-bloggers.com/2023/07/the-benjamini-hochberg-procedure-fdr-and-p-value-adjusted-explained/

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Jun 28 2024 This Week in Cardiology Jun 28, 2024

Screening echo, multivitamins, wasteful research, another PA sensor for HF, vascular closure devices, and GLP-1 marketing as science research are the topics John Mandrola, MD, discusses this week.

This podcast is intended for healthcare professionals only.

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I. Screening for Valvular HD in the Elderly

EHJ-CV Imaging Paper https://doi.org/10.1093/ehjci/jeae127

II. Vitamins and Wasteful Research

Is Red Meat Healthy? Multiverse Analysis Has Lessons Beyond Meat https:// www.medscape.com/viewarticle/red-meat-healthy-multiverse-analysis-has-lessons-beyond-meat-2024a10008qv

May 10, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1000772

Multivitamin Paper https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820369
Physicians Health Study II https://jamanetwork.com/journals/jama/fullarticle/1389615

III. FDA Has Approved Another PA Sensor

Link to slides https://c212.net/c/link/?t=0&l=en&o=4104690-1&h=4197477262&u=https%3A%2F%2Fendotronix.com%2FEndotronix-PROACTIVE-HF-LBCT-THT-2024.pdf&a=here

IV. Vascular Closure Devices in Electrophysiology.

Vascular Closure Devices Study https://onlinelibrary.wiley.com/doi/full/10.1111/jce.16345

V. SURMOUNT-OSA

SURMOUNT OSA Paper https://www.nejm.org/doi/full/10.1056/NEJMoa2404881
SELECT https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
June 21, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001237
JAMA Systematic Review and Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2643307
SAVE https://www.nejm.org/doi/full/10.1056/NEJMoa1606599
Norwegian study https://doi.org/10.1016/j.hrthm.2022.06.016

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Jun 21 2024 This Week in Cardiology Jun 21, 2024

MRAs in HF with renal dysfunction, coronary autoregulation, the hubris of US doctors, NSTEMI in older patients, survival after STEMI, and new leaders at JACC are discussed by John Mandrola, MD.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I Listener Feedback

Combined analysis (Matsumoto)

II Coronary artery autoregulation with increasing stenosis

NEJM Paper https://www.nejm.org/doi/full/10.1056/NEJMc2402216

III RECOVER IV Trial

Gregg Stone, MD Tweet https://x.com/GreggWStone/status/1803583552354742416
DANGER-Shock Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
Impella Saves Lives in Cardiogenic Shock, but Patient Selection Key https://www.medscape.com/viewarticle/1000659

IV NSTEMI Elderly

Main Paper
Datamethods https://discourse.datamethods.org/t/random-vs-fixed-effects-meta-analysis/7361
O’Fee Paper https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560

V MI Survival

Danish Paper https://doi.org/10.1016/j.jacc.2024.04.025

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Jun 14 2024 This Week in Cardiology Jun 14, 2024

Listener feedback, statin eligibility and Yogi Berra, evidence-based medicine and heterogenous treatment effects, and MRAs in HF are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Listener Feedback

ASPIRE AF https://classic.clinicaltrials.gov/ct2/show/NCT03968393
Butala paper: Stroke After TAVR With and Without EPD https://www.ahajournals.org/doi/abs/10.1161/CIRCINTERVENTIONS.123.013697
PROTECTED TAVR
Heuts meta-analysis: EPD During TAVR https://heart.bmj.com/content/110/11/757

II. Statin Eligibility

JAMA-IM: Data Analytic Choices and Predicting Vascular Events https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2819821
Zeraatker Specification Analysis Paper https://doi.org/10.1016/j.jclinepi.2024.111278
PCE https://www.mdcalc.com/calc/3398/ascvd-atherosclerotic-cardiovascular-disease-2013-risk-calculator-aha-acc

III. Heterogenous Treatment Effect

Weisberg and Dailey-Higgs
DANISH

IV. Heart Failure and MRAs

RALES https://www.nejm.org/doi/full/10.1056/NEJM199909023411001
EMPHASIS https://www.nejm.org/doi/full/10.1056/NEJMoa1009492
Combined analysis (Matsumoto)

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Jun 07 2024 This Week in Cardiology Jun 07, 2024

Cannabis and CV outcomes, post-CABG AF, embolic protection devices, emulation of randomization, and a preview heterogenous treatment effects are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Cannabis

It Sure Looks Like Cannabis Is Bad for the Heart, Doesn't It?

https://www.medscape.com/viewarticle/1000250

Cannabis Use Tied to Increased Cardiovascular Risk

https://www.medscape.com/viewarticle/cannabis-use-tied-increased-cardiovascular-risk-2024a10003yr

Medical Cannabis for Chronic Pain Tied to Arrhythmia Risk

https://www.medscape.com/viewarticle/medical-cannabis-chronic-pain-tied-arrhythmia-risk-2024a10000sc

Cannabis for Chronic Pain and CV Safety https://doi.org/10.1093/eurheartj/ehad834
Editorial https://academic.oup.com/eurheartj/article/45/6/485/7500073
Response to Letter https://doi.org/10.1093/eurheartj/ehae314
UCLA paper https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819559
Lifetime Cannabis Use and Mortality https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819635

II. Post Cardiac Surgery AF

Meta-analysis https://doi.org/10.1093/eurheartj/ehae267

III. Embolic Protection devices

Clear Stroke Benefit Eludes Embolic Protection: PROTECTED TAVR

https://www.medscape.com/viewarticle/980978

Embolic Protection and Stroke Prevention With TAVR https://www.ahajournals.org/doi/abs/10.1161/CIRCINTERVENTIONS.123.013697
PROTECTED TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2204961

IV. Preview of HTE

Paper https://doi.org/10.1016/j.ahj.2024.04.020

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May 31 2024 This Week in Cardiology May 31, 2024

The FLOW trial of semaglutide, the DANCAVAS CV screening trial, non-invasive tests for chest pain, and conflicts of interest on social media are the topics John Mandrola, MD, discusses this week.

This podcast is intended for healthcare professionals only.

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I. Semaglutide for CKD

Semaglutide Significantly Improves Chronic Kidney Disease

https://www.medscape.com/viewarticle/semaglutide-significantly-improves-chronic-kidney-disease-2024a10009w9

FLOW Trial

II. CV Screening

Judicious CVD Screening May Work in Men: DANCAVAS

https://www.medscape.com/viewarticle/980153

DANCAVAS 6-Year Outcomes https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004403
DANCAVAS Main Trial NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2208681

III. Non-invasive Cardiac Testing in Chest Pain

Circulation Outcomes Paper https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010457
Scot Heart https://www.nejm.org/doi/full/10.1056/NEJMoa1805971

IV. COI and Social Media

JAMA letter https://jamanetwork.com/journals/jama/fullarticle/2816900

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May 24 2024 This Week in Cardiology May 24, 2024

Clues in SCAF, a DOAC antidote trial, another negative lytic trial in stroke, JAMA changes to observational studies, and BP in stroke care are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

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I. ARTESIA Substudy

Sadly, ARTESIA Doesn't Answer a Common Question in Cardiology

https://www.medscape.com/viewarticle/998215

ARTESIA Substudy
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
ARTESIA https://www.nejm.org/doi/10.1056/NEJMoa2310234

II. DOAC Reversal

ANNEXA-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2313040

III. Lytic Therapy in Acute Stroke

Thrombolysis Offers No Benefit for Mild Stroke

https://www.medscape.com/viewarticle/iv-thrombolysis-offers-no-benefit-mild-stroke-2024a10009p7

TEMPO-2 Trial https://doi.org/10.1016/S0140-6736(24)00921-8
The Case Against Thrombolytic Therapy in Stroke

IV. Observational Research

JAMA Special Communication https://jamanetwork.com/journals/jama/fullarticle/2818746
JAMA editors note https://jamanetwork.com/journals/jama/fullarticle/2818747

V. Aggressive BP Control in Stroke

Guidelines on Rapid BP Reduction in Acute Ischemic Stroke Challenged

https://www.medscape.com/viewarticle/guidelines-rapid-bp-reduction-acute-ischemic-stroke-2024a10009pe

TRUTH Trial https://doi.org/10.1016/S1474-4422(24)00177-7

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May 17 2024 This Week in Cardiology May 17, 2024

An Impella update, another TAVI vs SAVR trial, two studies on angina and PCI, another null substudy from REVIVED-BCIS, and semaglutide are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

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I. Impella Update

CHRIP BCIS 3 https://classic.clinicaltrials.gov/ct2/show/NCT05003817
Danger-Shock Podcast https://www.medscape.com/viewarticle/1000675

II. TAVI vs SAVR

Notion 2 Trial EHJ https://doi.org/10.1093/eurheartj/ehae331
DEDICATE-DZHK6

III. Angina and PCI

Orbita 2 Sub-analysis
Orbita Star https://www.jacc.org/doi/10.1016/j.jacc.2024.04.001

IV. Complete Revascularization

Main REVIVED trial https://www.nejm.org/doi/full/10.1056/NEJMoa2206606
JACC Substudy https://www.jacc.org/doi/10.1016/j.jacc.2024.04.043

V. Semaglutide

Semaglutide CV Benefits Irrespective of Weight Loss: 4-Year SELECT Data

https://www.medscape.com/viewarticle/semaglutide-cv-benefits-irrespective-weight-loss-4-year-2024a100095z

Nature Med substudy https://www.nature.com/articles/s41591-024-02996-7
SELECT Main paper https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

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May 10 2024 This Week in Cardiology May 10, 2024

Inclisiran, sodium-channel blocker safety, analytic flexibility, the work-up of patients with HF, and BP in older patients are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

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I. Inclisiran Update

ORION 4 https://classic.clinicaltrials.gov/ct2/show/NCT03705234

II. Sodium-Channel AADs

UPenn Paper https://doi.org/10.1016/j.jacep.2024.01.021
Three Questions Editorial https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
EAST Post-hoc Review https://doi.org/10.1093/europace/euae121

III. Analytic Flexibility

Is Red Meat Healthy? Multiverse Analysis Has Lessons Beyond Meat

https://www.medscape.com/viewarticle/red-meat-healthy-multiverse-analysis-has-lessons-beyond-meat-2024a10008qv

Specification Curve Analysis of Red Meat Data https://doi.org/10.1016/j.jclinepi.2024.111278

IV. The Work-up of Patients With HF

Durstenfeld and colleagues, UCSF https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010800
REVIVED BCIS2 https://www.nejm.org/doi/full/10.1056/NEJMoa2206606

V. BP Therapy in Older Patients

Haring and colleagues; Women’s Health Initiative BP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067302
SPRINT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1511939

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May 03 2024 This Week in Cardiology May 03, 2024

The DEDICATE trial of TAVR vs SAVR, more on renal denervation, inclisiran, and marketing disguised as science are the topics John Mandrola, MD, discusses in today’s podcast.

This podcast is intended for healthcare professionals only.

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I. TAVR vs SAVR

TAVI Comparable With SAVR in Lower-Risk Aortic Stenosis

https://www.medscape.com/viewarticle/tavi-comparable-savr-lower-risk-aortic-stenosis-2024a100074o?form=fpf

DEDICATE https://www.nejm.org/doi/full/10.1056/NEJMoa2400685
Partner 3 https://www.nejm.org/doi/full/10.1056/NEJMoa1814052
Evolut Low Risk https://www.nejm.org/doi/full/10.1056/NEJMoa1816885
Barili meta-analysis https://doi.org/10.1093/ejcts/ezab516

II. Renal Denervation

Alcohol-Mediated Renal Denervation Promising in Hypertension

https://www.medscape.com/viewarticle/alcohol-mediated-renal-denervation-promising-hypertension-2024a10007eg

TARGET 1 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069291

III. Inclisiran

Earlier Inclisiran Gives Better Long-Term LDL Reductions

https://www.medscape.com/viewarticle/earlier-inclisiran-gives-better-long-term-ldl-reductions-2024a10007d6

VICTORIAN INITIATE Trial https://www.jacc.org/doi/10.1016/j.jacc.2024.03.382

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Apr 26 2024 This Week in Cardiology Apr 26, 2024

A listener defends colored boxes in guidelines; mysteries of non-culprit coronary lesions during PCI, and of AF ablation; and surrogate markers are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Mystery of What to Do in the Cath Lab after Fixing the Culprit Lesion – The FULL REVASC Trial

Complete Revascularization Not Superior to Culprit-Only PCI After MI

https://www.medscape.com/viewarticle/complete-revascularization-not-superior-culprit-only-pci-2024a10007ik

FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
FIRE Trial https://www.nejm.org/doi/10.1056/NEJMoa2300468
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
Cohen Tweet on FULL REVASC https://x.com/djc795/status/1781361606238085532

II. AF Ablation Mysteries

New Expert Consensus on Ablation Strategies for AF

https://www.medscape.com/viewarticle/new-expert-consensus-ablation-strategies-af-2024a1000851

Bern Study of Remapping https://doi.org/10.1016/j.jacep.2024.02.026
Natural History of SCAF https://doi.org/10.1016/j.jacc.2019.09.050
Liverpool Study: Thermal PV Isolation in Persistent AF https://doi.org/10.1016/j.hrthm.2024.04.061

III. Surrogate Markers

JAMA: Surrugate Markers and Clinical Outcomes https://jamanetwork.com/journals/jama/fullarticle/2817850
BP Surrogate Meta-analysis https://doi.org/10.1016/S0140-6736(21)00590-0
JAMA: Nonfatal MI as Surrogate for Mortality https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560

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Apr 19 2024 This Week in Cardiology Apr 19, 2024

ACC Part 2: The TACT2 trial of chelation, inter-atrial shunts for HF, and triglyceride lowering; plus diltiazem and Factor Xa anticoagulants are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. TACT 2

Chelation Therapy Provides No Benefit Post-MI

https://www.medscape.com/viewarticle/chelation-therapy-provides-no-benefit-post-mi-2024a10006l5

Chelation Therapy and CV Risk: Why TACT2 Showed No Benefit https://www.medscape.com/viewarticle/chelation-therapy-and-cv-risk-why-tact2-showed-no-benefit-2024a1000761?src=

JAMA TACT 1 paper https://jamanetwork.com/journals/jama/fullarticle/1672238
Diabetes Subgroup paper https://pubmed.ncbi.nlm.nih.gov/24254885/
A New Look at P-values https://evidence.nejm.org/doi/abs/10.1056/EVIDoa2300003
PARAGON HF https://www.nejm.org/doi/full/10.1056/NEJMoa1908655

II. Interatrial Shunts for HF

No Net HF Benefit for Interarterial Shunt Device

https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk

REDUCE LAP HF II https://doi.org/10.1016/S0140-6736(22)00016-2

III. Triglyceride Lowering

Early Olezarsen Results Show 50% Reduction in Triglycerides

https://www.medscape.com/viewarticle/early-olezarsen-results-show-50-reduction-triglycerides-2024a10006oz

Is It Time to Stop Treating High Triglycerides?

https://www.medscape.com/viewarticle/990126

NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2402309

Substantial Triglyceride Reduction With Plozasiran

https://www.medscape.com/viewarticle/substantial-triglyceride-reduction-plozasiran-2024a10006wf?icd=login_success_email_match_norm

JAMA Cardiology https://jamanetwork.com/journals/jamacardiology/article-abstract/2817469

IV. Diltiazem and Factor Xa inhibitors

JAMA Vanderbilt University Paper https://jamanetwork.com/journals/jama/fullarticle/2817546

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Apr 12 2024 This Week in Cardiology Apr 12, 2024

ACC Recap #1: DanGer Shock (plus a sobering JAMA research letter on Impella use), REDUCE-AMI, PREVENT, and EMPACT-MI are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. DanGer-Shock Trial

Impella CP Improves Survival in STEMI, Cardiogenic Shock https://www.medscape.com/viewarticle/impella-cp-improves-survival-stemi-cardiogenic-shock-2024a10006kz

Impella Saves Lives in Cardiogenic Shock, but Patient Selection Key https://www.medscape.com/viewarticle/1000659

Published DanGer Shock Study https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
JAMA Research letter https://jamanetwork.com/journals/jama/article-abstract/2817457

II. REDUCE-AMI Trial

New Data Question Beta-Blockers Post-MI With Preserved EF https://www.medscape.com/viewarticle/new-data-question-beta-blockers-post-mi-preserved-ef-2024a10006y8

Beta-Blockers Post-MI Past Their Expiration Date: REDUCE-AMI https://www.medscape.com/viewarticle/1000663

REDUCE-AMI paper https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
Meta-analysis: Beta Blockers for MI https://doi.org/10.1016/j.amjmed.2014.05.032

III. PREVENT Trial

Preventive PCI for Vulnerable Plaques Reduces Cardiac Events

https://www.medscape.com/viewarticle/preventive-pci-vulnerable-plaques-reduces-cardiac-events-2024a10006tc

Preventive Coronary Stents: Not There Yet

https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr

PREVENT https://doi.org/10.1016/S0140-6736(24)00413-6

IV. EMPACT MI trial of Empagliflozin in the Post-MI setting

Empagliflozin Fails to Reduce Events After Acute MI

https://www.medscape.com/viewarticle/empagliflozin-fails-reduce-events-after-acute-mi-2024a10006kn

EMPACT-MI: Another SGLT2 Inhibitor Miss in Post-MI Care https://www.medscape.com/viewarticle/1000684
EMPACT MI https://www.nejm.org/doi/10.1056/NEJMoa2314051
DAPA MI https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300286
PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508
Kaul thread https://x.com/kaulcsmc/status/1776611935842165029
Kaul paper https://www.ahajournals.org/doi/full/10.1161/circulationaha.116.022537

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Apr 05 2024 This Week in Cardiology Apr 05, 2024

Statins and diabetes, AAD in patients with heart disease, tricuspid valve interventions, and an ACC preview are the topics John Mandrola, MD, discusses in this week’s podcast.This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Statins and Diabetes

Meta-analysis in Lancet-Diabetes https://doi.org/10.1016/S2213-8587(24)00040-8
Editorial https://doi.org/10.1016/S2213-8587(24)00059-7
NEJM Paper on Gene Variants and DM https://www.nejm.org/doi/full/10.1056/nejmoa1604304
JAMA Paper on Gene Variants and DM https://jamanetwork.com/journals/jama/fullarticle/2565289

II. Anti-arrhythmic Drugs in Patients With Serious Heart Disease

UPenn Paper on AADs for PVC Suppression https://doi.org/10.1016/j.jacep.2024.01.021
Three Questions for Evidence-Based Cardiac EP https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
CAST trial https://www.nejm.org/doi/full/10.1056/NEJM199103213241201

III. Tricuspid Valve Interventions

FDA Clears TriClip for Tricuspid Regurgitation

https://www.medscape.com/viewarticle/fda-clears-triclip-tricuspid-regurgitation-2024a100068o

FDA Panel in Favor of TriClip for Tricuspid Regurgitation

https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n

Slides for Trisend II
TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525

IV. ACC Preview

Mandrola's Three Trials to Look for at the 2024 American College of Cardiology Scientific Sessions

https://www.medscape.com/viewarticle/1000613

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Mar 29, 2024 This Week in Cardiology Podcast Mar 29, 2024

Intermittent fasting, anticoagulation decisions, heterogenous treatment effects, frailty in HF, the importance of the ECG, and industry conflicts are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Intermittent Fasting

No, Intermittent Fasting Won't Kill You

https://www.medscape.com/viewarticle/1000544

NEJM Paper on Time-Restricted Eating https://www.nejm.org/doi/full/10.1056/NEJMoa2114833
JAMA TREAT Clinical Trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771095

II. Stroke Prevention with OAC

Shah Meta analysis of Vitamin K Agonists in AF https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010269

III. Heterogenous Treatment Effects in Trials

Pivotal CV Trials May Not Apply to Complex Patients

https://www.medscape.com/viewarticle/989129

Analysis of 8 Trials of Multimorbidity and Treatment Response https://doi.org/10.1016/j.amjmed.2024.01.028

IV. Frailty and HF

Circulation Outcomes: Multidomain Frailty and Mode of Death in HF https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010416

V. ECG in LBBB

JAMA Cardiology: Revised Definition of LBBB https://jamanetwork.com/journals/jamacardiology/fullarticle/2816973

VI. Industry Payments to Doctors

JAMA: Payments to US Physicians by Specialty https://jamanetwork.com/journals/jama/fullarticle/2816900

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Mar 22 2024 This Week in Cardiology Mar 22, 2024

p>Obesity drugs as ASCVD-modifiers, HR monitors, when journals publish obvious facts, and effect scores and sorting out signals from RCTs are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Denmark Notes

II. FDA approval of Semaglutide

FDA Approves Semaglutide for Cardiovascular Risk Reduction

https://www.medscape.com/viewarticle/fda-approves-semaglutide-cardiovascular-risk-reduction-2024a10004ix

Select Trial

III. PPG Monitor Accuracy

Research Letter https://doi.org/10.1016/j.jacc.2024.01.024

IV. AAD and Bradycardia

Anti-arrhythmic Drugs Linked to Bradycardia in Patients With AF

https://www.medscape.com/viewarticle/anti-arrhythmic-drugs-linked-bradycardia-patients-af-2024a10004vw

JACC paper on AAD Adverse Effects https://doi.org/10.1016/j.jacc.2024.01.013

V. Finding Signals in RCTs

JAMA paper on Treatment Effects of Oxygen Targets
DANISH trial https://www.nejm.org/doi/full/10.1056/nejmoa1608029
LAFFLIN et al. Scoring System to Assess Generalizability of Trial Results https://doi.org/10.1177/2047487318815967

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Mar 08 2024 This Week in Cardiology Mar 08, 2024

Plastics and heart disease, MINT trial letters-to-the-editor and Bayes theorem, and Brugada syndrome are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Plastics and Heart Disease

Plastic Particles in Carotid Plaques Linked to CV Events

https://www.medscape.com/viewarticle/plastic-particles-carotid-plaques-linked-cv-events-2024a10004ge

Plastics and ASCVD Study https://www.nejm.org/doi/full/10.1056/NEJMoa2309822
Review https://www.nejm.org/doi/full/10.1056/NEJMra2300476
Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2400683

II. MINT trial LTE and Bayes Theorem

In MI With Anemia, Results May Favor Liberal Transfusion: MINT https://www.medscape.com/viewarticle/998376

The MINT Study https://www.nejm.org/doi/full/10.1056/NEJMoa2307983
Letter-to-the-Editor https://www.nejm.org/doi/full/10.1056/NEJMc2400982
Likelihood Ratio https://www.cebm.ox.ac.uk/resources/ebm-tools/likelihood-ratios

III. Brugada Syndrome

The EHJ paper: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae133/7623123

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Mar 1 2024 This Week in Cardiology Mar 01, 2024

The Western AF meeting, aspirin, cannabis use, LVEF in athletes, and shared decision making before ICD implantation are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. ASA in Primary Prevention

Campbell Meta-analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065420
Swedish Observational study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.028321
ASPREE https://www.nejm.org/doi/full/10.1056/NEJMoa1805819

II. Cannabis

Cannabis Use Tied to Increased Cardiovascular Risk

https://www.medscape.com/viewarticle/cannabis-use-tied-increased-cardiovascular-risk-2024a10003yr

It Sure Looks Like Cannabis Is Bad for the Heart, Doesn’t It?

https://www.medscape.com/viewarticle/1000250

Journal of the AHA Observational Study https://www.ahajournals.org/doi/full/10.1161/JAHA.123.030178

III. Low EF in Athletes

Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.063777

IV. ICDs and Shared Decision-Making

Association of a Medicare Mandate for Shared Decision-Making With Cardiac Device Utilization https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2815017

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Feb 23 2024 This Week in Cardiology Feb 23, 2024

Reading incidental CAC on chest CT scans, exercise benefits in women vs men, PCI with or without imaging, and trial non-reporting are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. Incidental CAC on Chest CT

Incidental CAC
Tweet
When Does a Calcium Score Equate to Secondary Prevention?: Insights From the Multinational CONFIRM Registry https://doi.org/10.1016/j.jcmg.2023.03.008

II. Exercise

Health Gains of Exercise Greater in Women?

https://www.medscape.com/viewarticle/health-gains-exercise-greater-women-2024a10003fv

Sex Differences in Association of Physical Activity With All-Cause and Cardiovascular Mortality

III. PCI With or Without Imaging

Intravascular Imaging in PCI: Time for a Guideline Update?

https://www.medscape.com/viewarticle/995677

Meta-analysis paper Lancet https://doi.org/10.1016/S0140-6736(23)02454-6
Imaging uptake paper https://doi.org/10.1093/eurheartj/ehad430

IV. Trial Non-reporting

The Ghost Research Haunting Nordic Medical Trials

https://www.medscape.com/viewarticle/ghost-research-haunting-nordic-medical-trials-2024a10003gz

Manuscript/preprint https://www.medrxiv.org/content/10.1101/2024.02.04.24301363v1#T10
Nissen (Rosiglitazone) https://www.nejm.org/doi/10.1056/NEJMoa072761

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Feb 16 2024 This Week in Cardiology Feb 16, 2024

An update in trial interpretation, CI, and P-values; percutaneous tricuspid Interventions; and news on HDL and humility in Medicine are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

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I. Evidence of Absence Is not Absence of Evidence

Feb 09, 2024 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1000101

ARCADIA Trial https://jamanetwork.com/journals/jama/fullarticle/2814933
FOURIER Trial https://www.nejm.org/doi/full/10.1056/nejmoa1615664
Sample Size Calculator https://clincalc.com/stats/samplesize.aspx

II. Tricuspid Valve Interventions

FDA OKs First Transcatheter Tricuspid Valve Replacement

https://www.medscape.com/viewarticle/fda-oks-first-transcatheter-tricuspid-valve-replacement-2024a10002dq

FDA Panel in Favor of TriClip for Tricuspid Regurgitation

https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n

Cardiothoracic Surgical Trials Network Study https://www.nejm.org/doi/full/10.1056/NEJMoa2115961
TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525
KAUL Tweet on ATTR Cardiomyopathy https://twitter.com/kaulcsmc/status/1753552603534016622?s=20
APOLLO B trial https://www.nejm.org/doi/full/10.1056/NEJMoa2300757
Al-Lamee Tweet on Sham Controls https://x.com/rallamee/status/1758236588570562736

III. HDL Cholesterol

Rationale paper — AEGIS https://doi.org/10.1016/j.ahj.2020.10.052
Press Release AEGIS II https://www.prnewswire.com/news-releases/csl-announces-top-line-results-from-the-phase-3-aegis-ii-trial-evaluating-the-efficacy-and-safety-of-csl112-apolipoprotein-a-i-human-302059156.html

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Feb 09 2024 This Week in Cardiology Feb 09, 2024

Beta-blocker withdrawal in HFpEF, the ARCADIA trial, food as medicine, and bariatric surgery are the topics John Mandrola, MD, discusses in today’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. HFpEF and Heart Rate

PRESERVE HF Substudy https://jamanetwork.com/journals/jamacardiology/fullarticle/2814596
PRESERVE HF Original https://doi.org/10.1016/j.jacc.2021.08.073

II. ARCADIA trial

ARCADIA Main Paper: Apixaban vs ASA https://jamanetwork.com/journals/jama/fullarticle/2814933
KAMEL’s AF and Stroke Paper 10.1161/STROKEAHA.115.012004
AVERROES Substudy -- 10.1016/S1474-4422(12)70017-0

III. Food as Medicine

Food-As-Medicine Trial results: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2812982
NPR Story https://www.npr.org/sections/thesalt/2017/05/08/526952657/fresh-food-by-prescription-this-health-care-firm-is-trimming-costs-and-waistline

IV. Bariatric Surgery

Weight Loss Surgery Yields Long-Term BP Control in Obesity

https://www.medscape.com/viewarticle/weight-loss-surgery-yields-long-term-bp-control-obesity-2024a10002le

Gateway RCT https://doi.org/10.1016/j.jacc.2023.11.032

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Feb 02 2024 This Week in Cardiology Feb 02, 2024

FDA approves PFA for AF ablation, flawed comparisons of TEER vs MV surgery and PCI vs CABG, and cardiologists struggling with board exams are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. PFA

FDA Okays Boston Scientific PFA System for Paroxysmal AF

https://www.medscape.com/viewarticle/fda-okays-boston-scientific-pfa-system-paroxysmal-af-2024a1000275

Pulsed-Field Ablation for AF: The Promise and the Reality

https://www.medscape.com/viewarticle/995675

ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
EU-PORIA Registry https://doi.org/10.1093/europace/euad185
Tomlinson/Mandrola Editorial https://www.jacc.org/doi/10.1016/j.jacc.2020.07.032

II. TEER vs MV Surgery

EHJ Paper https://doi.org/10.1093/eurheartj/ehae046

III. ISCHEMIA Post-Hoc Studies

JACC Post-Hoc ISCHEMIA Trialhttps://doi.org/10.1016/j.jacc.2023.11.002
Main ISCHEMIA paper https://www.nejm.org/doi/full/10.1056/nejmoa1915922
FAME 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2112299

IV. Board Exams

More Cardiologists Failing the Boards, Why and How to Fix?

https://www.medscape.com/viewarticle/more-cardiologists-failing-boards-why-and-how-fix-2024a10001oi

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Jan 26 2024 This Week in Cardiology Jan 26, 2024

LAAO, more evidence that stable CAD is stable, CRT benefit over the long-term, and AF monitoring after stroke are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

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I. LAAO

This Week in Cardiology Podcast, Dec 15, 2023 https://www.medscape.com/viewarticle/999282

European Heart Journal paper https://academic.oup.com/eurheartj/article/45/3/214/7471675
LAAOS 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2101897

II. CAD after Transcatheter Aortic Valve Implantation

Cleveland Clinic Observational study https://doi.org/10.1093/eurheartj/ehae019
ACTIVATION trial https://doi.org/10.1016/j.jcin.2021.06.041

III. Cardiac Resynchronization Therapy

Original RAFT 2010 https://www.nejm.org/doi/full/10.1056/nejmoa1009540
Long-term RAFT https://www.nejm.org/doi/full/10.1056/NEJMoa2304542
Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2312419

IV. AF Monitoring After Stroke

Japanese Observational Study https://www.ahajournals.org/doi/10.1161/JAHA.123.031508
ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
LOOP substudy https://jamanetwork.com/journals/jamaneurology/fullarticle/2795865
CRYSTAL AF https://www.nejm.org/doi/full/10.1056/nejmoa1313600

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Jan 19 2024 This Week in Cardiology Jan 19, 2024

Listener feedback on antiplatelet therapy after PCI, bempedoic acid, off-Label PFO Closure, and palliative care are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Listener Feedback on Antiplatelet Therapy After PCI

Long-term Clopidogrel Has Advantages After Coronary Stenting

https://www.medscape.com/viewarticle/long-term-clopidogrel-has-advantages-after-coronary-stenting-2024a10000c8

Host Exam Study; Extended FU of Host-Exam https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062770

II. Bempedoic Acid

This Week in Cardiology July 7, 2023 https://www.medscape.com/viewarticle/994089

NEJM: Bempedoic Acid and CV Outcomes

JAMA: Primary Prevention Analysis https://jamanetwork.com/journals/jama/fullarticle/2806646

JAMA-Cardiology: Total Events Analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2813647/

III. Off-Label PFO Closure

Circulation Outcomes Paperhttps://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010200

IV. Palliative Care

JAMA: Palliative Care Consultation

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Jan 12 2024 This Week in Cardiology Jan 12, 2024

GLP-1s and BaroStim Neo revisited, a new drug for transthyretin amyloid CM, clopidogrel vs ASA years after PCI and stent, and statins are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. GLP-1s and Obesity, BaroStim Neo Revisited

FDA Expands Label for CVRx Barostim System in HF https://www.medscape.com/viewarticle/fda-expands-label-cvrx-barostim-system-hf-2023a1000wsx

JAMA Cardiology Special Communication – BDP https://jamanetwork.com/journals/jamacardiology/fullarticle/2810726

II. ATTR Cardiomyopathy

ATTRibute-CM NEJM paper https://www.nejm.org/doi/full/10.1056/NEJMoa2305434

Circulation Review of TTR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.111.078915

ATTR-ACT (Tafadimis) https://www.nejm.org/doi/10.1056/NEJMoa1805689

III. Clopidogrel vs ASA Years After PCI

Long-term Clopidogrel Has Advantages After Coronary Stenting

https://www.medscape.com/viewarticle/long-term-clopidogrel-has-advantages-after-coronary-stenting-2024a10000c8

Stop DAPT Original Trial

STOP DAPT at 5 Years https://doi.org/10.1016/j.jacc.2023.10.013

Network Meta-analysis of P2Y12-I vs ASA https://doi.org/10.1016/j.jcin.2022.08.009

IV. Statin Use

Statin Use Remains Low for At-Risk Patients

https://www.medscape.com/viewarticle/999043

Annals of Internal Medicine Observational Study https://doi.org/10.7326/M23-1915

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Jan 05 2024 This Week in Cardiology Jan 05, 2024

Neuro-modulation in HF, private equity owned hospitals, HCM, SCD and ICD re-evaluated, and peer review are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Neuromodulation for HFrEF

FDA Expands Label for CVRx Barostim System in HF

https://www.medscape.com/viewarticle/fda-expands-label-cvrx-barostim-system-hf-2023a1000wsx

BeAT HF trial https://doi.org/10.1016/j.jacc.2020.05.015

II. Private Equity Takeover of US Hospitals

Hospital Adverse Events Rise After Private Equity Acquisition

https://www.medscape.com/viewarticle/hospital-adverse-events-rise-after-private-equity-2023a1000wya

Changes in Hospital Adverse Events and Patient Outcomes Associated With Private Equity Acquisition: https://jamanetwork.com/journals/jama/article-abstract/2813379

RSS audio: https://bi.medscape.com/pi/editorial/studio/audio/2024/core/999557.mp3

III. Hypertrophic Cardiomyopathy

Positive Topline Results for SEQUOIA-HCM Trial in OHCM

https://www.medscape.com/viewarticle/positive-topline-results-sequoia-hcm-trial-ohcm-2023a1000wu9

IV. The ICD gets a ReLook

Study to Examine Routine ICD Implantation Post Heart Attack

https://www.medscape.com/viewarticle/study-examine-routine-icd-implantation-post-heart-attack-2023a1000wmd

PROFID Site https://profid-project.eu/profid-ehra-trial/

Declining Risk of Sudden Death in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1609758

V. Peer Review

Prevalence of Short Peer Reviews in 3 Leading General Medical Journals -- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812883

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Dec 15 2023 This Week in Cardiology Dec 15, 2023

FDA approves PFA, breakthrough in PAH, residual leaks after percutaneous LAAO, OAC in low to intermediate risk people are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. FDA Approves PFA

FDA Approves First Pulsed Field Ablation System for AF https://www.medscape.com/viewarticle/fda-approves-first-pulsed-field-ablation-system-af-2023a1000vit

- PULSED AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064329

- ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291

- MANIFEST https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064959

II. Pulmonary HTN

Positive Topline Data for Sotatercept in PAH: STELLAR

https://www.medscape.com/viewarticle/982407

- STELLAR https://www.nejm.org/doi/10.1056/NEJMoa2213558

- Editorial on STELLAR https://www.nejm.org/doi/full/10.1056/NEJMe2300324

III. Peri-Device Leaks

- Greek Meta-analysis https://doi.org/10.1093/eurheartj/ehad828

IV. Intermediate Risk AF – Norwegian Study

- Stroke and bleeding risk in atrial fibrillation with CHA2DS2-VASC risk score of one: the Norwegian AFNOR study AFNOR Study https://doi.org/10.1093/eurheartj/ehad659

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Dec 08 2023 This Week in Cardiology Dec 08, 2023

Three aspects of the recent AF guideline documents and a possible new treatment of POTS are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I AF Guidelines

ACC/AHA Issue Updated Atrial Fibrillation Guideline

https://www.medscape.com/viewarticle/998956

- Guideline doc: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193

- CASTLE AF https://www.nejm.org/doi/full/10.1056/nejmoa1707855

- Analysis of US Inpatient Sample https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-73

- RAFT AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057095

- Beta Blockers in AF https://pubmed.ncbi.nlm.nih.gov/25193873/

Section 2 AF Guidelines – EARLY Rhythm Control Gets Emphasis

- STOP AF https://www.nejm.org/doi/full/10.1056/NEJMoa2029554

- EARLY AF https://www.nejm.org/doi/full/10.1056/nejmoa2029980

- EAST https://www.nejm.org/doi/full/10.1056/NEJMoa2019422

- Natural History of AF https://www.jacc.org/doi/abs/10.1016/j.jacc.2019.09.050

Section 3 AF Guidelines – Dubious Upgrade of percutaneous LAAC

- PROTECT and PREVAIL Meta-analysis 5-year https://doi.org/10.1016/j.jacc.2017.10.021

- PINNACLE FLX https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.050117

II. Postural Orthostatic tachycardia Syndrome

Vagus Nerve Stimulation Promising In POTS

https://www.medscape.com/viewarticle/998913

- Stavrakis et al. Noninvasive VNS for POTS https://doi.org/10.1016/j.jacep.2023.10.015

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Dec 01 2023 This Week in Cardiology Dec 01, 2023

More from AHA including SGLT2 inhibitors, blood transfusion after MI; cracks in the armor of Factor XI inhibitors; and renal denervation are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. DAPA MI

Potential Dapagliflozin Benefit Post-MI Is Not a 'Mandate'

https://www.medscape.com/s/viewarticle/998378

- NEJM Evidence: Dapagliflozin After MI https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300286

II. Blood Transfusion Strategy Post MI

In MI With Anemia, Results May Favor Liberal Transfusion: MINT

https://www.medscape.com/viewarticle/998376

- MINT NEJM -- https://www.nejm.org/doi/full/10.1056/NEJMoa2307983

- REALITY https://jamanetwork.com/journals/jama/fullarticle/2776201

- PROTECTED TAVR - https://www.nejm.org/doi/full/10.1056/NEJMoa2204961

III. FACTOR XI

Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA

https://www.medscape.com/viewarticle/998418

Asundexian Phase 3 AF Study Halted for Lack of Efficacy

https://www.medscape.com/viewarticle/998665

- Abelacimab for VTE https://www.nejm.org/doi/full/10.1056/NEJMoa2105872

IV. Renal Denervation

FDA Panel Split on Efficacy of Spyral Renal Denervation

https://www.medscape.com/viewarticle/995800

FDA OKs Symplicity Renal Denervation System for Hypertension

https://www.medscape.com/viewarticle/998664

- SPYRAL HTN OFF MED -- https://doi.org/10.1016/S0140-6736(20)30554-7

- SPRYAL HTN On Meds (Pilot Lancet 2018 ) https://doi.org/10.1016/S0140-6736(18)30951-6

- SPRYAL HTN ON Meds (Expansion Pilot) https://doi.org/10.1016/j.jacc.2023.08.045

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Nov 17 2023 This Week in Cardiology Nov 17, 2023

An AHA Recap: SELECT, ORBITA2, and ARTESIA are the trials John Mandrola, MD, reviews in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

American Heart Association 2023 on theHeart.org | Medscape Cardiology

https://www.medscape.com/viewcollection/37277

I. SELECT Trial

Semaglutide 'A New Pathway' to CVD Risk Reduction: SELECT

https://www.medscape.com/viewarticle/998373

Positive Results From SELECT Begins a New Era in Cardiology

https://www.medscape.com/viewarticle/998217

Is It Time for Cardiologists to Treat Obesity?

https://www.medscape.com/viewarticle/998391

- SELECT trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

- SUSTAIN 6 https://www.nejm.org/doi/full/10.1056/nejmoa1607141

II. ORBITA 2

Angioplasty Finally Proven Beneficial in Stable Angina: ORBITA-2

https://www.medscape.com/s/viewarticle/998375

ORBITA-2 Saves Interventional Cardiology and Challenges Current Guidance

https://www.medscape.com/viewarticle/998213

PCI, the Antianginal 'Pill': ORBITA-2 in Detail

https://www.medscape.com/viewarticle/997777

- ORBITA-2; NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2310610

- ORBITA 1 https://doi.org/10.1016/S0140-6736(17)32714-9

III. ARTESIA

Apixaban Cuts Stroke but Ups Bleeding in Subclinical AF: ARTESIA

https://www.medscape.com/viewarticle/998379

Sadly, ARTESIA Doesn't Answer a Common Question in Cardiology

https://www.medscape.com/viewarticle/998215

- NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062

- ARTESIA https://www.nejm.org/doi/10.1056/NEJMoa2310234

- AVERROES https://www.nejm.org/doi/full/10.1056/NEJMoa1007432

- McIntyre Meta-analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067512

- TRENDS https://www.ahajournals.org/doi/10.1161/circep.109.849638

- ASSERT https://doi.org/10.1093/eurheartj/ehx042

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Nov 10 2023 This Week in Cardiology Nov 10, 2023

Renal denervation, a potential deadly decision in the ED, GLP-1 agonists, and an AHA preview are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Renal Denervation

FDA OKs Paradise Renal Denervation System for Hypertension

https://www.medscape.com/viewarticle/998237

- Company Press Release https://www.recormedical.com/recor-medical-and-otsuka-medical-devices-announce-first-fda-approved-renal-denervation-system-for-the-treatment-of-hypertension/

- Six-month Meta-analysis of RDN Studies https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.123.066941

- March This Week in Cardiology with RDN Discussion https://www.medscape.com/viewarticle/989014

II. Potential Deadly Decisions in the ED

Even One Night in the ED Raises Risk for Death

https://www.medscape.com/viewarticle/998080

- JAMA Internal Medicine Study

III. Tirzepatide Approval

FDA Approves Tirzepatide for Treating Obesity

https://www.medscape.com/viewarticle/998225

- SURMOUNT 2 https://doi.org/10.1016/S0140-6736(23)01200-X

- SURMOUNT 1 https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

IV. AHA Preview

Mandrola's Top Trials to Look for at AHA 2023

https://www.medscape.com/viewarticle/998123

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Nov 03 2023 This Week in Cardiology Nov 03, 2023

Tricuspid regurgitation therapy, two more left atrial appendage trials, and reflections on being too soft on medical science are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Tricuspid Regurgitation

Trilogy TAVR Safe, Effective in Aortic Regurgitation

https://www.medscape.com/viewarticle/997782

The TRILUMINATE Transcatheter Tricuspid Repair Trial: Positive but No Benefit?

https://www.medscape.com/viewarticle/989105

Transcatheter Tricuspid Valve Repair Effective, Safe for Regurgitation: TRILUMINATE

https://www.medscape.com/s/viewarticle/989103

- TRILUMINATE NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2300525

II. LAA Occlusion

Different Strengths for LAA Closure Devices?

https://www.medscape.com/viewarticle/962893

- Swiss Apero – Original paper https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057859

- Swiss Apero – One-year https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067599

Peri-device Leaks After Watchman https://pubmed.ncbi.nlm.nih.gov/35902169/

TAVR With Left Atrial Appendage Occlusion Non-inferior to TAVR Plus Medical Therapy https://www.medscape.com/viewarticle/997725

- WATCH TAVR Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067312

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Oct 27 2023 This Week in Cardiology Oct 27, 2023

More on the Million Hearts RCT, ENRICH AF, TAVI vs SAVR, the Partner 3 and Evolut-low-risk trials, and myocardial viability are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Listener Feedback Million Hearts

CMS 'Million Hearts' CVD Risk Reduction Model Works

https://www.medscape.com/viewarticle/997551

- RCT JAMA - https://jamanetwork.com/journals/jama/fullarticle/2810696

AC in ICH - ENRICH AF

Oral Anticoagulation in ICH Patients With AF: New Data https://www.medscape.com/viewarticle/997547

- Lancet Neurology Meta-analysis https://doi.org/10.1016/S1474-4422(23)00315-0

- ENRICH AF letter https://doi.org/10.1016/S0140-6736(23)02025-1

II. TAVI vs SAVR

Low-Risk TAVR Studies: Divergent Long-Term Results

https://www.medscape.com/viewarticle/997784

- Partner 3 Main Results

- Partner 3 – Five Year

- Original EVOLUT -LR https://www.nejm.org/doi/10.1056/NEJMoa1816885

- EVOLUT 3-year https://doi.org/10.1016/j.jacc.2023.02.017

- EVOLUT -LR 4-year https://doi.org/10.1016/j.jacc.2023.09.813

III. Myocardial Viability

Viability-Guided PCI Doubted in Stable Severe CAD: REVIVED-BCIS2

https://www.medscape.com/viewarticle/989101

- Revived BCIS – Original paper https://www.nejm.org/doi/10.1056/NEJMoa2206606

- JAMA Cardiology Viability paper https://jamanetwork.com/journals/jamacardiology/fullarticle/2810727

- STICH Viability Paper - https://www.nejm.org/doi/full/10.1056/NEJMoa1100358

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Oct 20 2023 This Week in Cardiology Oct 20, 2023

Listener feedback, oral anticoagulation in patients with ICH, an example of statistical significance but not clinical significance, and statins and diabetes are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Listener Feedback

October 13, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/997281

- European Heart Journal: IVI for PCI https://doi.org/10.1093/eurheartj/ehad430

- Elgendy Meta-analysis of Imaging in PCI: https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.116.003700

- ULTIMATE: https://www.jacc.org/doi/10.1016/j.jacc.2018.09.013

- ILUMEIN IV: https://www.nejm.org/doi/full/10.1056/NEJMoa2305861

- OCTOBER: https://www.nejm.org/doi/full/10.1056/NEJMoa2307770

- Main STEP-HFpEF paper

- Letter to the Editor on Lack of Obesity Paradox https://doi.org/10.1016/j.amjcard.2019.04.037

II. Anticoagulation in ICH

Oral Anticoagulation in ICH Patients With AF: New Data https://www.medscape.com/viewarticle/997547

- Lancet Neuro Meta-analysis https://doi.org/10.1016/S1474-4422(23)00315-0

- ENRICH AF letter https://doi.org/10.1016/S0140-6736(23)02025-1

III. Million Hearts

CMS 'Million Hearts' CVD Risk Reduction Model Works https://www.medscape.com/viewarticle/997551

- RCT JAMA

IV. Statin Choice and Diabetes

April 7, 2023 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/990542

- LODESTAR Main Study

- LODESTAR Substudy

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Oct 13 2023 This Week in Cardiology Oct 13, 2023

Three stories regarding GLP-1 agonists, imaging during PCI, and the power of sham controls in procedure trials are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. FLOW Trial Positive

Novo Nordisk Stops Ozempic Kidney Trial After Early Signs of Success https://www.medscape.com/s/viewarticle/997237

- FLOW Trial – press release https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=166327

II. STEP HFpEF

Semaglutide Win in HFpEF With Obesity Regardless of Ejection Fraction: STEP-HFpEF

https://www.medscape.com/viewarticle/997185

The GLP-1 Agonist Semaglutide in HFpEF Cleared a Low Bar

https://www.medscape.com/viewarticle/995872

- STEP HFpEF substudy

- STEP HFpEF main paper

III. GLP-1 Agonist Adverse Effects

GLP-1 Agonists Linked to Higher Risk for Rare but Serious GI Complications

https://www.medscape.com/viewarticle/997128

- GI Adverse Effects of GLP-1 Agonists https://jamanetwork.com/journals/jama/fullarticle/2810542

IV. Imaging in PCI

Intravascular Imaging in PCI: Time for a Guideline Update?

https://www.medscape.com/viewarticle/995677

- Intravascular imaging during percutaneous coronary intervention: temporal trends and clinical outcomes in the USA https://academic.oup.com/eurheartj/article/44/38/3845/7226277

- HEART Review of Studies of Intracoronary Imaging During PCI https://heart.bmj.com/content/107/9/755

V. The Power of Placebo (Sham) control

Hopeful Insights, No Overall HFpEF Gains From Splanchnic Nerve Ablation: REBALANCE-HF

https://www.medscape.com/viewarticle/997318

- Transvenous Right GSN Ablationin HFpEF https://doi.org/10.1016/j.jchf.2022.05.009

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Oct 06 2023 This Week in Cardiology Oct 06, 2023

Coated vs uncoated ASA, a new trial in CAD, conflicts of interest, first AF in the hospital, and changing HTN scoring and CHADSVASC are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. ASA

No Benefit of Enteric-Coated Aspirin vs Uncoated in CVD https://www.medscape.com/viewarticle/997119

- JAMA Cardiology: Coated vs Uncoated ASA https://jamanetwork.com/journals/jamacardiology/fullarticle/2809795

- ADAPTABLE https://www.nejm.org/doi/10.1056/NEJMoa2102137

II. RECHARGE

- Revascularization Choices Among Under-Represented Groups Evaluation (The RECHARGE Program) https://www.pcori.org/research-results/2023/revascularization-choices-among-under-represented-groups-evaluation-recharge-program

- Gaudino/Stone: Reconsidering Coronary Revascularization Trials

III. Conflicts of Interest

- Financial Conflicts of Interest in Public Comments on Medicare National Coverage Determinations of Medical Devices https://jamanetwork.com/journals/jama/fullarticle/2808721

IV. First AF in the Hospital

Decoding AFib Recurrence: PCPs' Role in Personalized Care https://www.medscape.com/viewarticle/997011

- Annals of Internal Medicine: AF Recurrence https://doi.org/10.7326/M23-1411

V. Changing CHADSVASC Score

- JAMA Network Open: HTN Guidelines and CHADSVASC Up-Scoring https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809933

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Sep 29 2023 This Week in Cardiology Sep 29, 2023

Reader feedback, leadless pacing, ABIM, SGLT2 inhibitors, peri-operative MI after cardiac surgery, and. AHA late-breakers are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Reader Feedback

Sep 22, 2023 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/996694

- ODYSSEY OUTCOMES trial https://www.nejm.org/doi/full/10.1056/nejmoa1801174

- FOURIER https://www.nejm.org/doi/full/10.1056/nejmoa1615664

II. Leadless Pacing

- Leadless vs Transvenous Pacemaker Study https://doi.org/10.1093/europace/euad269

III. ABIM News

Heart Societies Ready to Split From ABIM Over Long-Standing MOC Disputes

https://www.medscape.com/viewarticle/996747

IV. SGLT2 inhibitors

Empagliflozin Gets FDA Nod for CKD Without T2D or HF

https://www.medscape.com/viewarticle/996873

- EMPA-Kidney https://www.nejm.org/doi/full/10.1056/NEJMoa2204233

V. Peri-Op MI after Cardiac Surgery

Cardiac Troponin Predicts Mortality Post Surgery

https://www.medscape.com/viewarticle/996877

- Austrian Perioperative MI study https://doi.org/10.1016/j.jacc.2023.07.011

- Vision https://www.nejm.org/doi/10.1056/NEJMoa2000803

VI. AHA Late Breakers

- Link to Late-Breakers https://professional.heart.org/en/meetings/scientific-sessions/programming/late-breaking-science#late-breaking

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Sep 22 2023 This Week in Cardiology Sep 22, 2023

Coronary calcium, cardiac arrest survival, Factor XI drug findings, APCs and a potential new board certification in cardiology are the topics discussed by John Mandrola, MD in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Coronary Artery Calcium

- CONFIRM Registry - https://doi.org/10.1016/j.jcmg.2023.03.008

- CURE -- https://www.nejm.org/doi/full/10.1056/nejmoa010746

II Cardiac Arrest

Cardiac Arrest Centers No Benefit in OHCA Without STEMI

https://www.medscape.com/viewarticle/995885

- Cycling coverage https://velo.outsideonline.com/road/road-racing/nathan-van-hooydonck-forced-to-end-to-racing-career-due-to-heart-condition/

- ARREST https://doi.org/10.1016/S0140-6736(23)01351-X

- SCD in Athletes Bob Harrington and Manesh Patel https://www.medscape.com/viewarticle/995575

III Factor XI

Trial Halted for Bleeding Reduction With Abelacimab vs Rivaroxaban in AF

https://www.medscape.com/viewarticle/996587

- Press Release - https://anthostherapeutics.com/wp-content/uploads/2023/09/2023-09-18-Anthos-Press-Release-final.pdf

- Abelacimab, a Factor XI Inhibitor, Prevents VTE With Low Bleeding Risk in Knee Replacement

- NEJM proof-of-concept https://www.nejm.org/doi/full/10.1056/NEJMoa2105872

- OCEANIC-AF https://classic.clinicaltrials.gov/ct2/show/NCT05643573

- Will Factor XI Be the Goldilocks Anticoagulant Target? https://www.medscape.com/viewarticle/979634

IV APC Care

NPs and PAs Handling Increasingly More Primary Care Visits: New Studies https://www.medscape.com/viewarticle/996709

BMJ paper -- https://www.bmj.com/content/382/bmj-2022-073933

V Possible Cardiology Board Certification Changes

- Heart Societies Ready to Split From ABIM Over MOC Disputes https://www.medscape.com/viewarticle/996747

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Sep 15 2023 This Week in Cardiology Sep 15, 2023

Reader feedback, imaging in the cath lab, AF ablation to relieve anxiety, and some possible help in hypertension are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Reader Feedback

Sep 08, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/996233

First Clinical Trial of CTO Procedures Fails to Deliver https://www.medscape.com/viewarticle/877405

- DanGerShock trial https://pubmed.ncbi.nlm.nih.gov/31176289/

II. Imaging in the Cath Lab

Should Intravascular Imaging Be Almost Routine in PCI? https://www.medscape.com/viewarticle/996375

- ILUMIEN IV https://www.nejm.org/doi/full/10.1056/NEJMoa2305861

- OCTOBER https://www.nejm.org/doi/full/10.1056/NEJMoa2307770

III. AF Ablation to Relieve Anxiety

- REMEDIAL Trial https://jamanetwork.com/journals/jama/fullarticle/2809419

- Sohaib and Francis; Meta analysis of Symptomatic Response Effect of CRT Pacing https://pubmed.ncbi.nlm.nih.gov/24259043/

IV. HTN

'New Dawn' for Aldosterone as Drug Target in Hypertension? https://www.medscape.com/viewarticle/996316

- TARGET HTN - https://jamanetwork.com/journals/jama/fullarticle/2809625

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Sep 08 2023 This Week in Cardiology Sep 08, 2023

ESC Recap Part 2: ECLS-SHOCK, FIRE, MULTISTARS-AMI, HEART FID, and DANPACE II are the trials John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Cardiogenic Shock

ECMO for Shock in Acute MI Won't Help, May Harm: ECLS-SHOCK https://www.medscape.com/viewarticle/995882

- ECLS-SHOCK trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307227

- ECMO-CS trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062949

II. FIRE TRIAL

FIRE a Win for Physiology-Guided MI Complete Revascularization in Older Patients https://www.medscape.com/viewarticle/995875

- FIRE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2300468

- COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775

III. Immediate vs Staged Revascularization

Parity for Prompt vs Staged STEMI Complete Revascularization: MULTISTARS-AMI https://www.medscape.com/viewarticle/995961

- MULTISTARS AMI trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823

- Complete Revascularization Now Compulsory? MULTISTARS-AMI and FIRE in Context https://www.medscape.com/viewarticle/995676

IV. Iron-Supplementation in Heart Failure

IV Iron Shows Only Modest Benefit in HF: HEART-FID https://www.medscape.com/viewarticle/995874

- HEART-FID https://www.nejm.org/doi/full/10.1056/NEJMoa2304968

- EHJ meta-analysis of Iron Supplementation https://doi.org/10.1093/eurheartj/ehad586

V. AF Prevention with Pacing

Minimizing Atrial Pacing No Benefit in Sinus Node Disease: DANPACE II https://www.medscape.com/viewarticle/996076

- DANPACE II https://doi.org/10.1093/eurheartj/ehad564

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Sep 01 2023 This Week in Cardiology Sep 01, 2023

ESC Wrap-up 1: Obesity, heart failure with preserved EF and reduced EF, AF, frailty, evidence translation, and catheter ablation are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. FRAIL AF

-FRAIL-AF Study

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066485

-The Most Important Study From ESC: FRAIL-AF

https://www.medscape.com/viewarticle/996063

II. STEP-HFpEF

Wegovy Scores HFpEF Benefits in People With Obesity

https://www.medscape.com/viewarticle/995844

GLP-1 Agonist Semaglutide in HFpEF Cleared Low Bar

https://www.medscape.com/viewarticle/995872

Semaglutide’s Big Step in HFpEF With Obesity: Investigator Inteview

https://www.medscape.com/viewarticle/995673

-Semaglutide in Obese Patients With HFpEF

https://www.nejm.org/doi/full/10.1056/NEJMoa2306963

III. NOAH AFNET 6

Anticoagulation No Benefit in Presumed AF Detected by Cardiac Devices

https://www.medscape.com/viewarticle/995861

How Much AF Warrants Anticoagulation? NOAH-AFNET 6 Provides Clues

https://www.medscape.com/viewarticle/995871

-NOAH AFNET-6 – NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa2303062

IV. ADVENT

Pulsed Field Ablation Challenges Conventional Devices in AF

https://www.medscape.com/viewarticle/995884

Pulsed Field Ablation Noninferior but Underwhelming in ADVENT

https://www.medscape.com/viewarticle/995898

-PPFA vs Thermal Ablation for PAF

https://www.nejm.org/doi/10.1056/NEJMoa2307291

V. BUDAPEST CRT

Impact of RV Pacing in Heart Failure, CRT Benefit Shown in BUDAPEST-CRT

https://www.medscape.com/viewarticle/996035

Supporting Evidence for a Common Practice: BUDAPEST CRT

https://www.medscape.com/viewarticle/995880

-BUDAPEST CRT Study: European Heart Journal

https://doi.org/10.1093/eurheartj/ehad591

VI. CASTLE HTx

Advanced HF No Obstacle to AF Ablation Success: CASTLE-HTx

https://www.medscape.com/viewarticle/995897

AF Ablation in End-Stage HF: Is CASTLE-HTx Too Good to Be True?

https://www.medscape.com/viewarticle/995974

-CASTLE AF (2018)

https://www.nejm.org/doi/full/10.1056/nejmoa1707855

-CASTLE HTx

https://www.nejm.org/doi/full/10.1056/NEJMoa2306037

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Aug 25 2023 This Week in Cardiology Aug 25, 2023

GLP-1 agonists in HFpEF, DOACs for subclinical AF, renal denervation, and the matter of remaining in the profession are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Obesity and HFpEF

GLP-1 Agonists in HFpEF With Obesity: Are We There Yet? https://www.medscape.com/viewarticle/993980

Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844

- Semaglutide in Obese Patients With HFpEF https://www.nejm.org/doi/full/10.1056/NEJMoa2306963

- Rationale/Protocol Paper https://doi.org/10.1016/j.jchf.2023.05.010

II. DOAC for Subclinical AF

- NOAH-AFNET 6 Rationale/Protocol https://doi.org/10.1016/j.ahj.2017.04.015

- NOAH-AFNET 6 Trial Results https://www.nejm.org/search?q=NOAH+AFNET

III. Renal Denervation

ReCor Renal Denervation System Safe, Effective: FDA Panel https://www.medscape.com/viewarticle/995741

FDA Panel Split on Efficacy of Spyral Renal Denervation https://www.medscape.com/viewarticle/995800

SPYRAL HTN-ON MED https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00455-X/fulltext

IV. Maintenance of Certification

As MOC Debate Heats Up, Cardiology Societies Weigh In https://www.medscape.com/viewarticle/moc-debate-heated-cardiology-societies-weigh-2023a1000jju

Features

Mandrola's 5 Things to Look for at the Upcoming ESC 2023

https://www.medscape.com/viewarticle/995614

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Aug 18 2023 This Week in Cardiology Aug 18, 2023

ICD generator change, less is more in VT management, co-morbidity in HF, and SGLT2i after AF ablation are the topics discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. ICD Gen Change

- Patients’ Perspectives Regarding Generator Exchanges of Implantable Cardioverter Defibrillators https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.122.009827

- DEFINITE https://www.nejm.org/doi/10.1056/nejmoa033088

- SCD-HeFT https://www.nejm.org/doi/full/10.1056/nejmoa043399

- DANISH https://www.nejm.org/doi/10.1056/NEJMoa1608029

- Poole and colleagues; 11-year follow-up of SCD-HeFT https://doi.org/10.1016/j.jacc.2020.05.061

- Editorial – Howell/Stecker https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010266

II. VT Therapy

Crossed Wires: Ischemia Testing and Monomorphic VT Storm

https://www.medscape.com/viewarticle/995401

- Cleveland Clinic Study

https://doi.org/10.1016/j.jacep.2023.04.030

III. Co-Morbidity in HF

- Hospital admissions in the last year of life of patients with heart failure

https://doi.org/10.1093/ehjqcco/qcad047

- Four Horsemen of Apocalypse Lecture

http://www.louisvillelectures.org/imblog/2017/10/5/whw8sf0m1k0wi6lm6kvjsx4nxzzjg5

IV. SGLT2i After Ablation for AF

SGLT2 Inhibitors Curb AF Post-Ablation Recurrences in Diabetes

https://www.medscape.com/viewarticle/995415

- Observational Study – Abu-Qaoud et al

https://www.jacc.org/doi/full/10.1016/j.jacep.2023.06.008

- Meta-analysis SGLT2i and AF

https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022222

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Aug 11, 2023 This Week in Cardiology Podcast Aug 11, 2023

Observational studies, another defense of digoxin, CTO-PCI, BP measurement, and a possible revolution in cardiovascular protection are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Observational Research

Yeh; Credibility in Observational Research https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064645

Hernan; Causal Language in Observational Research https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2018.304337

Wang; RCT Duplicate Initiative https://jamanetwork.com/journals/jama/fullarticle/2804067

II. Defense of Digoxin

Brophy; Beta Blockers, Digoxin, or Both https://doi.org/10.1016/j.cjca.2023.06.009

Dorian editorial https://doi.org/10.1016/j.cjca.2023.07.013

Ziff Digoxin Meta-analysis https://www.bmj.com/content/351/bmj.h4451.long

DIG trial https://www.nejm.org/doi/full/10.1056/nejm199702203360801

Davila Analysis of DIG Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801940/

Kotecha Meta-analysis of Beta Blockers https://pubmed.ncbi.nlm.nih.gov/25193873/

RATE-AF https://jamanetwork.com/journals/jama/fullarticle/2774407

III. CTO-PCI

PCI of Chronic Total Occlusions Improves Angina, Quality of Life in Trials https://www.medscape.com/viewarticle/994739

JAMA Network Open Meta-analysis

IV. BP Measurement

One Size Doesn’t Fit All in Blood Pressure Measurement https://www.medscape.com/viewarticle/995216

Ishigami Blood Pressure Measurement Comparison

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2807853

V. GLP-1 SELECT Trial

Semaglutide Cuts Cardiovascular Events in Landmark Trial

https://www.medscape.com/viewarticle/995270

SELECT Protocol Paper

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Aug 04 2023 This Week in Cardiology Aug 04, 2023

Listener feedback re observational studies, surgeons’ dissent from recent guidelines, aspirin for primary prevention, and fish oil are the topics discussed by John Mandrola.MD in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Heart Surgeons Dissent

Surgical Groups Push Back Against New Revascularization Guidelines

https://www.medscape.com/viewarticle/966153

New Revascularization Guidelines: Key Points and Navigating Controversies

https://www.medscape.com/viewarticle/972014

- AHA Guidelines - https://doi.org/10.1161/CIR.0000000000001168

- AATS statement 2023 https://doi.org/10.1016/j.jtcvs.2023.03.001

- Yusef and colleagues 1994 Meta-analysis - https://doi.org/10.1016/S0140-6736(94)91963-1

- 10-year SYNTAXES https://doi.org/10.1016/S0140-6736(19)31997-X

- Surgeons’ argument 2021 https://doi.org/10.1016/j.athoracsur.2021.12.003

- FAME 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2112299

- Gaudino Meta-analysis of Medical Therapy vs CABG https://doi.org/10.1016/j.jtcvs.2022.06.003

- NOBLE https://doi.org/10.1016/S0140-6736(19)32972-1

- EXCEL 5 years https://www.nejm.org/doi/full/10.1056/nejmoa1909406

II. ASA for Primary Prevention

Daily Aspirin Challenged in Primary Stroke Prevention: ASPREE

https://www.medscape.com/viewarticle/994963

- ASPREE – All-cause mortality

- ASPREE (MACE and Bleeding) https://www.nejm.org/doi/full/10.1056/NEJMoa1805819

- ASPREE (disability) https://www.nejm.org/doi/full/10.1056/NEJMoa1800722

- JAMA Network Open Subanalysis https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807630

III. Fish Oil

- OMEMI Substudy https://doi.org/10.1016/j.clnu.2023.07.002

- Gencer and colleagues Meta-analysis - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654

- OMEMI Main Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.052209

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Jul 28 2023 This Week in Cardiology Jul 28, 2023

Antiarrhythmic drugs in patients with CAD, observational studies, GLP-1 agonists, and the subcutaneous ICD are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. AAD in Patients with CAD

- The Feasibility and Safety of Flecainide Use Among Patients With Varying Degrees of Coronary Disease

https://doi.org/10.1016/j.jacep.2022.12.021

- Three Questions for Evidence-Based Cardiac Electrophysiology

https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381

- The Cardiac Arrhythmia Suppression Trial (CAST) https://www.nejm.org/doi/full/10.1056/nejm198908103210608

II. GLP-1 Agonists

Tirzepatide Powers Weight Loss in Two More Pivotal Trials https://www.medscape.com/viewarticle/994889

Semaglutide Use Surges in US Adults With Type 2 Diabetes https://www.medscape.com/viewarticle/994873

- Tirzepatide Once Weekly for the Treatment of Obesity

https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

- Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

https://doi.org/10.1016/S0140-6736(23)01200-X

III. S-ICD

S-ICD Shows Virtues, Limits in 'Real World' Postmarket Study https://www.medscape.com/viewarticle/994851

- Postapproval Study of a Subcutaneous Implantable Cardioverter-Defibrillator System https://doi.org/10.1016/j.jacc.2023.05.034

- Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/full/10.1056/NEJMoa1915932

- Letter to the Editor https://www.nejm.org/doi/full/10.1056/NEJMc2034917

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Jul 21 2023 This Week in Cardiology Jul 21, 2023

Listener feedback, conduction system pacing, eating fish vs fish pills, exercise, and an RCT for diet are the topics discussed by John Mandrola,.MD, in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Listener Feedback Monitor HF and AHA

Jun 02, 2023 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/992678

- Link to the ACC Email -- https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2023/07/18/17/21/monitor-hf

- Tweet From Anthony Pearson

https://twitter.com/skepcard/status/1681288604990189574

II. Conduction System Pacing

- Clinical Outcomes in Conduction System Pacing Compared to Right Ventricular Pacing in Bradycardia https://doi.org/10.1016/j.jacep.2022.10.016

- Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women https://www.acpjournals.org/doi/abs/10.7326/0003-4819-117-12-1016

III. Fish Oil

Omega-3s and AF: No Added Risk From Eating Fish but High-Dose Supplement Questions Persist https://www.medscape.com/viewarticle/994559

- Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

https://www.jacc.org/doi/full/10.1016/j.jacc.2023.05.024

- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia https://www.nejm.org/doi/full/10.1056/nejmoa1812792

- Effect of Long-Term Marine ɷ-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654

IV. Exercise

Even Exercise by 'Weekend Warriors' Can Cut CV Risk

https://www.medscape.com/viewarticle/994617

- Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease https://jamanetwork.com/journals/jama/article-abstract/2807286

V. Diet

Cognitive Benefit of Highly Touted MIND Diet Questioned

https://www.medscape.com/viewarticle/994550

- Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons

https://www.nejm.org/doi/full/10.1056/NEJMoa2302368

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July 14 2023 This Week in Cardiology Jul 14, 2023

Carotid stents, the paclitaxel story now closed, inclisiran, DOAC failures, and primary vs secondary prevention are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Carotid Stenting CMS Proposal

Expanded Coverage of Carotid Stenting in CMS Draft Proposal

https://www.medscape.com/viewarticle/994315

No Added Benefit From Revascularization in Low-Risk CAS

https://www.medscape.com/viewarticle/992524

- Percutaneous Transluminal Angioplasty (PTA) of the Carotid Artery Concurrent with Stenting https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=Y&NCAId=311

- Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

https://doi.org/10.1016/S0140-6736(21)01910-3

- SPACE-2 https://journals.sagepub.com/doi/10.1177/1747493019833017

- Rationale, Design, and Implementation of Intensive Risk Factor Treatment in the CREST2 Trial 10.1161/STROKEAHA.120.030730

II. Paclitaxel

FDA: No Excess Mortality Risk From Paclitaxel Stents, Balloons for Peripheral Intervention https://www.medscape.com/viewarticle/994253

- FDA Statement https://www.fda.gov/medical-devices/letters-health-care-providers/update-paclitaxel-coated-devices-treat-peripheral-arterial-disease-unlikely-increase-risk-mortality?utm_medium=email&utm_source=govdelivery#_FDA_Actions

III. Inclisiran

FDA Expands Inclisiran Statin-Adjunct Indication to Include Primary Prevention https://www.medscape.com/viewarticle/994185

- ORION 10-11 Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol https://www.nejm.org/doi/10.1056/NEJMoa1912387

- Effect of inclisiran on lipids in primary prevention: the ORION-11 trial

https://doi.org/10.1093/eurheartj/ehac615

- Inclisiran and cardiovascular events: a patient-level analysis of phase III trials https://pubmed.ncbi.nlm.nih.gov/36331326/

IV. DOAC Failure

Association of Alternative Anticoagulation Strategies and Outcomes in Patients With Ischemic Stroke While Taking a Direct Oral Anticoagulant

https://doi.org/10.1212/WNL.0000000000207422

V. Primary or Secondary Prevention

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Jul 7 2023 This Week in Cardiology Jul 07, 2023

European HTN Guidelines, vitamin D, bempedoic acid, and leadless pacing, with some critical appraisal techniques thrown in, are the topics John Mandrola, MD, tackles in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. European Hypertension Guidelines

New ESH Hypertension Guidelines Aim for Simplified Message

https://www.medscape.com/viewarticle/993913

- 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH)

https://pubmed.ncbi.nlm.nih.gov/37345492/

II. Vitamin D

CV Benefit From Vitamin-D Caps Hinted in Huge D-Health Trial

https://www.medscape.com/viewarticle/993996

- Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial

https://www.bmj.com/content/381/bmj-2023-075230

- Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials

https://jamanetwork.com/journals/jamacardiology/fullarticle/2735646

III. Bempedoic Acid

'Striking' Benefit of Lipid Lowering in Primary Prevention

https://www.medscape.com/viewarticle/993666

- Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients

https://jamanetwork.com/journals/jama/fullarticle/2806646

- Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease

https://jamanetwork.com/journals/jama/fullarticle/2806647

- Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

https://www.nejm.org/doi/full/10.1056/NEJMoa2215024

IV. Leadless Pacing

FDA Approves First Leadless Dual-Chamber Pacing System

https://www.medscape.com/viewarticle/994033

- A Dual-Chamber Leadless Pacemaker

https://www.nejm.org/doi/full/10.1056/NEJMoa2300080

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Jun 23 2023 This Week in Cardiology Jun 23, 2023

Starting HF meds during hospitalization for HF, Impella, testosterone, and colchicine are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Starting HF Meds During Hospitalization for HF

Starting Indicated Heart Failure Meds In-Hospital: Progress, Opportunities https://www.medscape.com/viewarticle/993539

- Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction https://www.jacc.org/doi/full/10.1016/j.jchf.2023.04.015

II. Impella

- Comparative Effectiveness of Percutaneous Microaxial Left Ventricular Assist Device vs Intra-Aortic Balloon Pump or No Mechanical Circulatory Support in Patients With Cardiogenic Shock

https://jamanetwork.com/journals/jamacardiology/fullarticle/2806562

- Evidence Generation for Novel Cardiovascular Devices—Putting the Horse Back in Front of the Cart

https://jamanetwork.com/journals/jamacardiology/fullarticle/2806565

III. Testosterone

Big Trial Reassures on Heart Safety of Testosterone in Men

https://www.medscape.com/viewarticle/993322

- Cardiovascular Safety of Testosterone-Replacement Therapy

https://www.nejm.org/doi/full/10.1056/NEJMoa2215025

IV. Colchicine for CV Disease

Low-Dose Colchicine Approved for CVD: Now What?

https://www.medscape.com/viewarticle/993578

- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

https://www.nejm.org/doi/full/10.1056/nejmoa1912388

- Colchicine in Patients with Chronic Coronary Disease

https://www.nejm.org/doi/full/10.1056/nejmoa2021372

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June 16 This Week in Cardiology Jun 16, 2023

AF screening, BNP, a new SGLT2 inhibitor, a sky-is-blue study, and the UK Mini Mitral surgical trial are discussed in this week's podcast

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I AF Screening

- Effects of Atrial Fibrillation Screening According to N-Terminal Pro-B-Type Natriuretic Peptide: A Secondary Analysis of the Randomized LOOP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064361

- Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01698-6

- Natural History of Subclinical Atrial Fibrillation Detected by Implanted Loop Recorders https://www.jacc.org/doi/full/10.1016/j.jacc.2019.09.050

- Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care https://jamanetwork.com/journals/jamacardiology/fullarticle/2801362

- Stepwise mass screening for atrial fibrillation using N-terminal pro b-type natriuretic peptide: the STROKESTOP II study design https://doi.org/10.1093/europace/euw319

- Current misconception 3: that subgroup-specific trial mortality results often provide a good basis for individualising patient care https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068511/

II Frailty and GDMT of HFrEF

Frailty Linked to Lower Use of Guideline Treatments in HFrEF

https://www.medscape.com/viewarticle/993218

- Physical Frailty and Use of Guideline‐Recommended Drugs in Patients With Heart Failure and Reduced Ejection Fraction https://www.ahajournals.org/doi/10.1161/JAHA.122.026844

III Sotagliflozin

FDA Approves New Drug, Sotagliflozin, for Heart Failure

https://www.medscape.com/viewarticle/992518

- Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease

https://www.nejm.org/doi/full/10.1056/NEJMoa2030186

- Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

https://www.nejm.org/doi/full/10.1056/NEJMoa2030183

IV Mini-Mitral

Support for Minimally Invasive Mitral Valve Repair: Mini Mitral Published

https://www.medscape.com/viewarticle/993191

- Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair

https://jamanetwork.com/journals/jama/article-abstract/2805908

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June 9 This Week in Cardiology Jun 09, 2023

Impella, digital health, low-value processes, are tricuspid valve interventions with pacing leads are the topics Dr. John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Impella Class I Recall

FDA Class I Recall for Some Abiomed Impella Heart Pumps

https://www.medscape.com/viewarticle/992845

- A Prospective, Randomized Clinical Trial of Hemodynamic Support With Impella 2.5 Versus Intra-Aortic Balloon Pump in Patients Undergoing High-Risk Percutaneous Coronary Intervention

https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.112.098194

- Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial Infarction

https://doi.org/10.1016/j.jacc.2016.10.022

https://www.sciencedirect.com/science/article/pii/S0735109716367675?via%3Dihub

- The Evolving Landscape of Impella Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention With Mechanical Circulatory Support

https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.044007

- Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock

https://jamanetwork.com/journals/jama/fullarticle/2761003

- Danish Cardiogenic Shock Trial (DanShock)

https://clinicaltrials.gov/ct2/show/NCT01633502

II. Wearable Devices

- Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805753 doi:10.1001/jamanetworkopen.2023.16634

- Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial

https://doi.org/10.1016/S0140-6736(21)01698-6

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01698-6/fulltext

- Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care

https://jamanetwork.com/journals/jamacardiology/fullarticle/2801362

III. The Cost of Quality Measures

- The Volume and Cost of Quality Metric Reporting

https://jamanetwork.com/journals/jama/fullarticle/2805705

- Goodhart's law

https://en.wikipedia.org/wiki/Goodhart%27s_law

IV. Tricuspid Valve Interventions and Pacing Leads

Leadless Dual-Chamber Pacemaker Clears Early Safety, Performance Hurdles

https://www.medscape.com/viewarticle/992464

- Transcatheter Tricuspid Valve Replacement With the EVOQUE System: 1-Year Outcomes of a Multicenter, First-in-Human Experience

https://www.jacc.org/doi/10.1016/j.jcin.2022.01.280

- Effects of Implantable Cardioverter-Defibrillator Leads on the Tricuspid Valve and Right Ventricle: A Randomized Comparison of Transvenous versus Subcutaneous Leads

https://eppro01.ativ.me/src/EventPilot/php/express/web/planner.php?id=HRS23&utm_source=heartrhythm&utm_medium=nav-button&utm_campaign=hr23-webtracking

- Management and Outcomes of Transvenous Pacing Leads in Patients Undergoing Transcatheter Tricuspid Valve Replacement

https://www.jacc.org/doi/10.1016/j.jcin.2020.04.054

- TRILUMINATE trial -- Transcatheter Repair for Patients with Tricuspid Regurgitation

https://www.nejm.org/doi/full/10.1056/NEJMoa2300525

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June 2 This Week in Cardiology Jun 02, 2023

Listener feedback on the most important study in a decade, MONITOR-HF, a flawed paper and analysis, and the tension between pathos and logos are the topics John Mandrola, MD discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Listener Feedback

Earlier Anticoagulation Safe in Stroke With AF: ELAN

https://www.medscape.com/viewarticle/992411

- Early versus Later Anticoagulation for Stroke with Atrial Fibrillation

https://www.nejm.org/doi/full/10.1056/NEJMoa2303048

- Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction

https://www.nejm.org/doi/full/10.1056/nejmoa1301092

II. Monitor HF

CardioMEMS Boosts QoL, Curbs HF Hospitalizations: MONITOR-HF

https://www.medscape.com/viewarticle/992333

- Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial

https://doi.org/10.1016/S0140-6736(23)00923-6

- Remote pulmonary artery pressure monitoring in heart failure care: part of the new normal?

https://doi.org/10.1016/S0140-6736(23)01010-3

- Sowell’s A Conflict of Visions

https://en.wikipedia.org/wiki/A_Conflict_of_Visions

III. Intensive BP Treatment in Older Patients – Pathos vs Logos

- Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older

Adultshttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2805021

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May 26 2023 This Week in Cardiology May 26, 2023

An HRS meeting recap, Impella failure, sacubitril/valsartan, the purpose of trials, and a major breakthrough in evidence generation are the topics discussed by John Mandrola, MD in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. HRS Meeting Recap

II. Impella in VT ablation

- First-in-human Experience with Impella 5.0/5.5 for High-Risk Patients with Advanced Heart Failure Undergoing VT Ablationhttps://www.jacc.org/doi/10.1016/j.jacc.2023.05.012

III. Sacubitril/Valsartan

ARNI Bests ARB to Reduce NT-proBNP in Stabilized Preserved-EF HF

https://www.medscape.com/viewarticle/992461

- Angiotensin-Neprilysin Inhibition in Patients With Mildly Reduced or Preserved Ejection Fraction and Worsening Heart Failure

https://www.jacc.org/doi/10.1016/j.jacc.2023.04.019

- Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/nejmoa1908655

- Sacubitril/valsartan in heart failure with mildly reduced or preserved ejection fraction: a pre-specified participant-level pooled analysis of PARAGLIDE-HF and PARAGON-HF

https://doi.org/10.1093/eurheartj/ehad344

- Bogdan Tweet

https://twitter.com/bogdienache/status/1660356776204595201?s=20

IV. Big Change in Reporting of Medical Evidence – Elan Trial

- Early versus Later Anticoagulation for Stroke with Atrial Fibrillationhttps://www.nejm.org/doi/full/10.1056/NEJMoa2303048

- Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial https://doi.org/10.1177/23969873221106043

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May 19 2023 This Week in Cardiology May 19, 2023

When to use an ICD, risk stratification for HCM, blending EP and structural cardiology to improve care in post-TAVI patients, and hsTroponins are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. ICD in Patients with NICM

Simple Risk Score Predicts VT in Nonischemic Cardiomyopathy

https://www.medscape.com/viewarticle/992018

- Declining Risk of Sudden Death in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1609758

- Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1608029

- Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar https://doi.org/10.1093/eurheartj/ehy437

- RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure (BRITISH) https://clinicaltrials.gov/ct2/show/NCT05568069

II. Risk Stratification in HCM

- Changing Risk Stratification in Hypertrophic Cardiomyopathy? https://www.medscape.com/viewarticle/992014

- NOAH–AFNET 6 trial terminates ahead of time (NOAH AFNET 6 trial) https://dzhk.de/en/news/latest-news/article/noah-afnet-6-trial-terminates-ahead-of-time-noah-afnet-6-trial/

III. Blending EP and Structural to Improve TAVI Care

- Impact of Right Ventricular Pacing in Patients With TAVR Undergoing Permanent Pacemaker Implantation https://www.jacc.org/doi/full/10.1016/j.jcin.2023.02.003

IV. Troponins

- Age-Specific Cut-Offs Needed for Cardiac Troponin Tests? https://www.medscape.com/viewarticle/992167

- Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in U.S. Adults https://www.jacc.org/doi/full/10.1016/j.jacc.2023.03.403

- What Is a Normal Troponin Anyway? https://www.jacc.org/doi/10.1016/j.jacc.2023.03.404

- Updating Our Thinking on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967

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May 12 2023 This Week in Cardiology May 12, 2023

Two new papers on left atrial appendage occlusion, the promise of DNA, statins in the elderly, and SGLT2 inhibitors are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Listener Feedback

- When to Start a Statin Is a Preference-Sensitive Decision

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808

II. Left Atrial Appendage Closure

LAA Closure Outcomes Improve With CCTA: Swiss-Apero Subanalysis

https://www.medscape.com/viewarticle/991623

- Impact of Preprocedural Computed Tomography on Left Atrial Appendage Closure Success: A Swiss-Apero Trial Subanalysis https://doi.org/10.1016/j.jcin.2023.02.027

- Outcomes of percutaneous left atrial appendage occlusion device implantation in atrial fibrillation patients based on underlying stroke risk https://doi.org/10.1093/europace/euad049

III. Polygenic Risk Scores

- Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease https://jamanetwork.com/journals/jama/fullarticle/2761086

- Cardiovascular Disease Risk Assessment Using Traditional Risk Factors and Polygenic Risk Scores in the Million Veteran Program https://jamanetwork.com/journals/jamacardiology/article-abstract/2804439

- Validity of polygenic risk scores: are we measuring what we think we are? https://doi.org/10.1093/hmg/ddz205

IV. Statins in Older Patients

High Cholesterol in Seniors: Use Statins for Primary Prevention?

https://www.medscape.com/viewarticle/991801

V. SGLT2 Inhibitors

FDA Expands Use of Dapagliflozin to Broader Range of HF

https://www.medscape.com/viewarticle/991736

- Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/NEJMoa2206286

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May 5 2023 This Week in Cardiology May 05, 2023

Beta-blockers post MI, public perception of statins, trust in the medical profession, BMI, and TAVI are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Post-MI Beta Blockers

Long-term Beta-Blockers Not Needed After MI with Preserved Systolic Function? https://www.medscape.com/viewarticle/991542

- Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes https://heart.bmj.com/content/early/2023/04/16/heartjnl-2022-322115

- Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

https://www.nejm.org/doi/full/10.1056/nejmoa1608029

II. Statin Perceptions

Statin Misinformation on Social Media Flagged by AI

https://www.medscape.com/viewarticle/991585

- Artificial Intelligence–Enabled Analysis of Statin-Related Topics and Sentiments on Social Media

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803988

III. BMI

BMI Is a Flawed Measure of Obesity. What Are Alternatives?

https://www.medscape.com/viewarticle/991210

IV. TAVI Access

Better Access to Transcatheter Aortic Valve Replacement Associated With Improved Outcomes

https://www.medscape.com/viewarticle/991573

- Regional Differences in Outcomes for Patients Undergoing Transcatheter Aortic Valve Replacement in New York State and Ontario https://doi.org/10.1016/j.cjca.2023.01.025

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Apr 28 2023 This Week in Cardiology Apr 28, 2023

Two studies of cardiac device infections, observational studies, RCTs, and our ways of knowing in Medicine are the topics discussed by John Mandrola, MD in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Cardiac Device Infection

Mortality Climbs When CIED Infections Are 'Delayed' After Implant

https://www.medscape.com/viewarticle/990692

- Association of the Timing and Extent of Cardiac Implantable Electronic Device Infections With Mortality

https://jamanetwork.com/journals/jamacardiology/fullarticle/2803627

- Low Utilization of Lead Extraction Among Patients With Infective Endocarditis and Implanted Cardiac Electronic Devices https://www.jacc.org/doi/full/10.1016/j.jacc.2023.02.042

- Cardiac Implantable Electronic Devices and Infective Endocarditis: A Call to Arms...∗ https://www.jacc.org/doi/full/10.1016/j.jacc.2023.02.043

II. Can RCTs be Emulated with Real World Evidence?

- Emulation of Randomized Clinical Trials With Nonrandomized Database Analyses https://jamanetwork.com/journals/jama/fullarticle/2804067

- Randomized Trials vs Real-world Evidence https://jamanetwork.com/journals/jama/fullarticle/2804092

- Reanalyses of Randomized Clinical Trial Data

https://jamanetwork.com/journals/jama/fullarticle/1902230

III. Multi-Morbidity Effects in Trials

Pivotal CV Trials May Not Apply to Complex Patients

https://www.medscape.com/viewarticle/989129

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Apr 21 2023 This Week in Cardiology Apr 21, 2023

John Mandrola, MD discusses early vs delayed AF ablation, a report on a devastating complication of AF ablation, and a potential crosswind for a major therapeutic fashion in electrophysiology.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I Early Vs Delayed Ablation

- Impact of Early Versus Delayed Atrial Fibrillation Catheter Ablation on Atrial Arrhythmia Recurrences

https://doi.org/10.1093/eurheartj/ehad247

- Diagnosis-to-Ablation Time and Recurrence of Atrial Fibrillation Following Catheter Ablation

https://www.ahajournals.org/doi/full/10.1161/CIRCEP.119.008128

- Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation

https://www.nejm.org/doi/full/10.1056/nejmoa2029980

- Progression of Atrial Fibrillation after Cryoablation or Drug Therapy

https://www.nejm.org/doi/full/10.1056/NEJMoa2212540

II Atrial-Esophageal Fistula

CT and Surgery Best Diagnose and Manage Esophageal Fistula

https://www.medscape.com/viewarticle/990933

- A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study https://doi.org/10.1093/eurheartj/ehad250

- Oesophageal Probe Evaluation in Radiofrequency Ablation of Atrial Fibrillation (OPERA): results from a prospective randomized trial https://doi.org/10.1093/europace/euaa209

- Temperature monitoring and temperature-driven irrigated radiofrequency energy titration do not prevent thermally induced esophageal lesions in pulmonary vein isolation: A randomized study controlled by esophagoscopy before and after catheter ablation https://doi.org/10.1016/j.hrthm.2021.02.003

III High-Power Short-Duration Ablation

Short, High-Power Ablation on Par With Standard AF Ablation

https://www.medscape.com/viewarticle/972087

- Power-Fast Trial

https://clinicaltrials.gov/ct2/show/NCT04153747

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Questions or feedback, please contact: news@medscape.net

Apr 14 2023 This Week in Cardiology Apr 14, 2023

SCAI consensus document on LAAC, semaglutide/tirzepatide disruption, NSAIDs, and interventional echocardiography are the topics discussed by John Mandrola, MD, on this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. SCAI Consensus Document

New Update on Left Atrial Appendage Closure Recommendations

https://www.medscape.com/viewarticle/990507

- SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure

https://doi.org/10.1016/j.jscai.2022.100577

- Transcatheter Left Atrial Appendage Closure Comes of Age

https://doi.org/10.1016/j.jscai.2023.100592

- EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion – an update https://doi.org/10.1093/europace/euz258

II. Semaglutide and Tirzepatide Disruption

Tirzepatide Powers 'Unprecedented' Weight Loss in Obesity Trial

https://www.medscape.com/viewarticle/975061

- Obesity Management in Primary Care

https://reference.medscape.com/recap/982874

- The $76 Billion Diet Industry Asks: What to Do About Ozempic?

https://www.wsj.com/amp/articles/ozempic-wegovy-mounjaro-weight-loss-industry-89419ecb

III. NSAIDs and HF

NSAID Use in Diabetes May Worsen Risk for First HF Hospitalization

https://www.medscape.com/viewarticle/990642

- Heart Failure Following Anti-Inflammatory Medications in Patients With Type 2 Diabetes Mellitus

https://doi.org/10.1016/j.jacc.2023.02.027

IV. Interventional Echocardiography

New ASE Guideline on Interventional Echocardiography Training

https://www.medscape.com/viewarticle/990520

- Recommendations for Special Competency in Echocardiographic Guidance of Structural Heart Disease Interventions: From the American Society of Echocardiography

https://doi.org/10.1016/j.echo.2023.01.014

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Questions or feedback, please contact: news@medscape.net

Apr 07 2023 This Week in Cardiology Apr 07, 2023

Chat GPT, a relatively unknown therapy for HFpEF, and two fun studies on statins and secondary prevention are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Artificial Intelligence and CHAT GPT

Can ChatGPT Replace Diabetes Educators? Perhaps Not Yet

https://www.medscape.com/viewarticle/990381

- Potential and Pitfalls of ChatGPT and Natural-Language Artificial Intelligence Models for Diabetes Education

https://doi.org/10.2337/dc23-0197

II. Exercise and HFpEF

AHA, ACC Advocate Supervised Exercise Training in HFpEF

https://www.medscape.com/viewarticle/990351

- Supervised Exercise Training for Chronic Heart Failure With Preserved Ejection Fraction: A Scientific Statement From the American Heart Association and American College of Cardiology

https://doi.org/10.1016/j.jacc.2023.02.012

III. Statins and Muscles

Statins Don't Worsen Muscle Injury From Moderately Intense Exercise

https://www.medscape.com/viewarticle/990473

- Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users https://doi.org/10.1016/j.jacc.2023.01.043

IV. Statins in Secondary Prevention

Treat to LDL Target or High-Intensity Statin for All With Clinical CAD: LODESTAR

https://www.medscape.com/viewarticle/989884

- Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease

https://jamanetwork.com/journals/jama/article-abstract/2802214

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact: news@medscape.net

Mar 31 2023 This Week in Cardiology Mar 31, 2023

Diets, coronary artery calcium, statins, basic CAD knowledge, and AF ablation are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Diet

Some Diets Better Than Others for Heart Protection https://www.medscape.com/viewarticle/990305

- Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis https://doi.org/10.1136/bmj-2022-072003

Plant-Based Diets Not Always Healthy; Quality Is Key https://www.medscape.com/viewarticle/990178

- Association of Healthful Plant-based Diet Adherence With Risk of Mortality and Major Chronic Diseases Among Adults in the UK https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802814

II. CAC and Statins

- Using the Coronary Artery Calcium Score to Guide Statin Therapy https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.113.000799

III. Subclinical Atherosclerosis

Subclinical CAD by CT Predicts MI Risk, With or Without Stenoses https://www.medscape.com/viewarticle/990254

- Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort

A Prospective Observational Cohort Study 0799 https://www.acpjournals.org/doi/10.7326/M22-3027

- A Prospective Natural-History Study of Coronary Atherosclerosis https://www.nejm.org/doi/10.1056/NEJMoa1002358?url_ver=Z39.88-2003

IV. AF ablation

- Standard vs Augmented Ablation of Paroxysmal Atrial Fibrillation for Reduction of Atrial Fibrillation RecurrenceThe AWARE Randomized Clinical Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2802860

- Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial FibrillationThe CAPLA Randomized Clinical Trial https://jamanetwork.com/journals/jama/article-abstract/2800186

- Approaches to Catheter Ablation for Persistent Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa1408288

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Questions or feedback, please contact news@medscape.net

Mar 24 2023 This Week in Cardiology Mar 24, 2023

Exercise, sudden cardiac death in sports, new TAVI data, behavioral psychology, EHR doing good things, maybe, and coffee are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Fitness and Longevity

Even Small Changes in Fitness Tied to Lower Mortality Risk https://www.medscape.com/viewarticle/989906

- Changes in Cardiorespiratory Fitness and Survival in Patients With or Without Cardiovascular Disease https://www.jacc.org/doi/full/10.1016/j.jacc.2023.01.027

II. SCD in Sports

Sports-Related Sudden Cardiac Arrest 'Extremely' Rare in Women https://www.medscape.com/viewarticle/990025

- Incidence of Cardiac Arrest During Sports Among Women in the European Union https://www.jacc.org/doi/full/10.1016/j.jacc.2023.01.015

- Sex-Related Differences in Sports-Related Sudden Cardiac Death Should Be Reflected in Guideline Screening Recommendations∗ https://www.jacc.org/doi/full/10.1016/j.jacc.2023.01.014

- Association between physical activity and risk of incident arrhythmias in 402 406 individuals: evidence from the UK Biobank cohort https://doi.org/10.1093/eurheartj/ehz897

III. EVOLUT Three Year Data

Encouraging 3-Year Data for TAVR in Low-Risk Patients: EVOLUT

https://www.medscape.com/viewarticle/989144

- Three-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients with Aortic Stenosis https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017

- Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients

https://www.nejm.org/doi/full/10.1056/nejmoa1816885

- Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk https://www.jacc.org/doi/10.1016/j.jacc.2020.12.052

IV. Behavioral Psychology

NUDGE-FLU: Electronic 'Nudges' Boost Flu Shot Uptake in Seniors https://www.medscape.com/viewarticle/989108

- The Effect of Electronic Nudges on Influenza Vaccination Rate in Older Adults With Cardiovascular Disease: a Prespecified Analysis of the NUDGE-FLU Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064270

- Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.057042

EHR Alerts Boosted MRA Prescribing in HFrEF: BETTER CARE-HF https://www.medscape.com/viewarticle/989110

- Cluster-Randomized Trial Comparing Ambulatory Decision Support Tools to Improve Heart Failure Care https://doi.org/10.1016/j.jacc.2023.02.005

- The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure https://www.nejm.org/doi/full/10.1056/nejm199909023411001

V. Coffee

- Acute Effects of Coffee Consumption on Health among Ambulatory Adults https://www.nejm.org/doi/full/10.1056/NEJMoa2204737

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Questions or feedback, please contact news@medscape.net

Mar 17 2023 This Week in Cardiology Mar 17, 2023

ACC Recap No. 2: Pacing in HFpEF, Oral PCSK9 inhibitor, PAH, soft thinking on adherence, and so called metabolically healthy obese are discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Pacing in HFpEF

No Exercise Boost From Pacemaker in HFpEF With Impaired HR Response: RAPID-HF https://www.medscape.com/viewarticle/989681

- Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection FractionThe RAPID-HF Randomized Clinical Trial https://jamanetwork.com/journals/jama/article-abstract/2802147

- Accelerated Pacing a Possible Strategy for Preserved-EF Heart Failure? https://www.medscape.com/viewarticle/987815

- Could a Breakthrough in Heart Failure With Preserved Ejection Fraction Just Take a Change of Pace? - https://www.medscape.com/viewarticle/988088

- Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrillation in Patients With Preclinical and Overt Heart Failure With Preserved Ejection Fraction: The myPACE Randomized Clinical Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2801001

- Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction https://doi.org/10.1016/j.jacc.2021.08.073

II Oral PCSK9i

Oral PCSK9 Inhibitor Shows Encouraging LDL Lowering https://www.medscape.com/viewarticle/989655

- Efficacy and safety of the oral PCSK9 inhibitor MK-0616: a phase 2b randomized controlled trial https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018

III PAH

'Unheard of' PAH Improvement With Novel Drug: STELLAR https://www.medscape.com/viewarticle/989612

- Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension https://www.nejm.org/doi/full/10.1056/NEJMoa2213558

IV Medical Adherence

Waiving Co-Pays for CV Meds as Adherence Incentive Doesn't Cut Clinical Risk: ACCESS Trial https://www.medscape.com/viewarticle/989474

- Eliminating Medication Copayments for Low-income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064188

- Medicaid Expansion: Good First Step, but No Panacea for CV Care https://www.medscape.com/viewarticle/975141

- Health Care Access and Management of Cardiovascular Risk Factors Among Working-Age Adults With Low Income by State Medicaid Expansion Status https://jamanetwork.com/journals/jamacardiology/article-abstract/2793120

- Rand Link https://www.rand.org/pubs/reports/R3055.html

- The Oregon Health Insurance Experiment https://www.healthaffairs.org/do/10.1377/hpb20150716.236899/full/

- Effect of Health Insurance in India: A Randomized Controlled Trial https://www.nber.org/papers/w29576

- Full Coverage for Preventive Medications after Myocardial Infarction https://www.nejm.org/doi/full/10.1056/nejmsa1107913

- Effect of Medication Co-payment Vouchers on P2Y12 Inhibitor Use and Major Adverse Cardiovascular Events Among Patients With Myocardial InfarctionThe ARTEMIS Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2720024

- Coronary CT Angiography and 5-Year Risk of Myocardial Infarction https://www.nejm.org/doi/full/10.1056/NEJMoa1805971

IV Metabolically Healthy Obese

'Metabolically Healthy Obesity' Rising, but Still Uncommon https://www.medscape.com/viewarticle/989398

- Trends in the Prevalence of Metabolically Healthy Obesity Among US Adults, 1999-2018 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802164

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Questions or feedback, please contact news@medscape.net

Mar 10 2023 This Week in Cardiology Mar 10, 2023

ACC Recap Part 1: Sports, bempedoic acid NASCARs, tricuspid regurgitation, and more on revascularization of stable CAD. are the topics discussed by John Mandrola, MD, in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Sports Cardiology

Even Vigorous Exercise Appears Safe for Patients With Hypertrophic Cardiomyopathy: LIVE-HCM https://www.medscape.com/viewarticle/989351

- Lifelong endurance exercise and its relation with coronary atherosclerosis https://doi.org/10.1093/eurheartj/ehad152

- Increased average longevity among the "Tour de France" cyclists https://pubmed.ncbi.nlm.nih.gov/21618162/

II. Clear Outcomes

Bempedoic Acid Cuts CV Events in Statin-Intolerant Patients: CLEAR Outcomes

https://www.medscape.com/viewarticle/989100

- Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients https://www.nejm.org/doi/full/10.1056/NEJMoa2215024

- Bodgan Enache Tweet https://twitter.com/bogdienache/status/1632143539965509632?s=20

III. TRILUMINATE Trial

Transcatheter Tricuspid Valve Repair Effective, Safe for Regurgitation: TRILUMINATE https://www.medscape.com/viewarticle/989103

- Transcatheter Repair for Patients with Tricuspid Regurgitation https://www.nejm.org/doi/full/10.1056/NEJMoa2300525

- New Treatment Could Help Fix the Heart’s ‘Forgotten Valve.’ https://www.nytimes.com/2023/03/04/health/tricuspid-valve-clip-leakage.html

- Rasha Al-Lamee Tweet https://twitter.com/rallamee/status/1632295242685612033?s=20

IV. REVIVED-BCIS

Viability-Guided PCI Doubted in Stable Severe CAD: REVIVED-BCIS2 https://www.medscape.com/viewarticle/989101

- Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction https://www.nejm.org/doi/full/10.1056/NEJMoa2206606

Features:

CLEAR Positives and Cautions With Bempedoic Acid for Statin Intolerance https://www.medscape.com/viewarticle/989098

The TRILUMINATE Transcatheter Tricuspid Repair Trial: Positive but No Benefit? https://www.medscape.com/viewarticle/989105

Three Surprising Studies on Exercise Restriction and an Exercise Sweet Spot https://www.medscape.com/viewarticle/989417

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Mar 3 2023 This Week in Cardiology Mar 03, 2023

Renal denervation, AF ablation, omecamtiv mecarbil, and an ACC Preview are the topics discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. AF Ablation

- Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures https://www.jacc.org/doi/10.1016/j.jacc.2022.11.060

II. Renal Denervation

Consistent BP Cut With Renal Denervation: More on RADIANCE https://www.medscape.com/viewarticle/989006

- Endovascular Ultrasound Renal Denervation to Treat HypertensionThe RADIANCE II Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2801849

- Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials https://jamanetwork.com/journals/jamacardiology/fullarticle/2802098

- Is There a Role for Renal Denervation in the Treatment of Hypertension? https://jamanetwork.com/journals/jamacardiology/fullarticle/2802099

III. Omecamtiv Mecarbil

FDA Declines Approval for Omecamtiv Mecarbil in HFrEF https://www.medscape.com/viewarticle/988948

IV. ACC Preview

ACC Scientific Session Returns Live, Virtually to New Orleans https://www.medscape.com/viewarticle/988803

- ‘Faith Healing’ and ‘Subtraction Anxiety’ in Unblinded Trials of Procedures https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.004665

Features

Mandrola's 5 Things to Look for at ACC 23 https://www.medscape.com/viewarticle/988808

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Feb 24 2023 This Week in Cardiology Feb 24, 2023

Reporting on potential fraud in medicine, AF, stroke, a possible new cholesterol-lowering drug, and the tone of debate in medical science are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Potential Fraud in Medicine

Inside the Big Business of Clogged Arteries https://www.medscape.com/viewarticle/988448

II. AF Screening and Stroke

STROKE AF at 3 Years: High AF Rate After Atherosclerotic Stroke https://www.medscape.com/viewarticle/988076

Severity and Etiology of Incident Stroke in Patients Screened for Atrial Fibrillation vs Usual Care and the Impact of Prior Stroke https://jamanetwork.com/journals/jamaneurology/fullarticle/2795865

III. Bempedoic Acid

New Studies Give Bempedoic Acid a Bump as Lipid-Lowering Agent https://www.medscape.com/viewarticle/911100

- Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance https://doi.org/10.1016/j.ahj.2020.10.060

- Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://www.nejm.org/doi/full/10.1056/NEJMoa1803917

- Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease https://jamanetwork.com/journals/jama/fullarticle/2754792

- N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173

- Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://www.jacc.org/doi/10.1016/j.jacc.2021.07.022

IV. The Technique of Critical Appraisal

Why Evidence-Based Medicine Enthusiasts Could Use a Lesson in Persuasion https://www.medscape.com/viewarticle/988227

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Questions or feedback, please contact news@medscape.net

Feb 17 2023 This Week in Cardiology Feb 17, 2023

Bradyarrhythmia during AF screening, thrombolysis in stroke, NP vs MD care, and the most biased paper this year — on LAAO — are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Screening with ILR

- Ade Adamson Tweet https://twitter.com/AdeAdamson/status/1625878856820482048?s=20

- The Rapid Rise in Cutaneous Melanoma Diagnoses

https://www.nejm.org/doi/full/10.1056/NEJMsb2019760

- Loop Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01698-6/fulltext

- Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care https://jamanetwork.com/journals/jamacardiology/fullarticle/2801362

II. Thrombolysis in Mild Stroke

Thrombolysis Not Necessary in Mild Nondisabling Stroke: ARAMIS

https://www.medscape.com/viewarticle/988381

- PRISMS Trial https://jamanetwork.com/journals/jama/fullarticle/2687354

- Risk of selection bias assessment in the NINDS rt-PA stroke study https://pubmed.ncbi.nlm.nih.gov/35705913/

- Tissue Plasminogen Activator for Acute Ischemic Stroke https://www.nejm.org/doi/full/10.1056/NEJM199512143332401

- Effects of alteplase for acute stroke; Hacke et al meta-analysis https://journals.sagepub.com/doi/10.1177/1747493017744464

- Methodological survey of missing outcome data in an alteplase for ischemic stroke meta-analysis

https://onlinelibrary.wiley.com/doi/full/10.1111/ane.13656

- ECASS; Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke https://www.nejm.org/doi/full/10.1056/nejmoa0804656

- Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances https://pubmed.ncbi.nlm.nih.gov/32430395/

III. NP vs MD Care

This Doc Still Supports NP/PA Led Care ... With Caveats https://www.medscape.com/viewarticle/967073

- The Productivity of Professions: Evidence from the Emergency Department https://www.nber.org/papers/w30608

- Independent Nurse Practitioners and Physician Assistants: A Doc's View https://www.medscape.com/viewarticle/924047

IV. LAAO vs OAC

- Comparative Effectiveness of Left Atrial Appendage Occlusio Versus Oral Anticoagulation by Sex

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062765

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Feb 10 2023 This Week in Cardiology Podcast Feb 10, 2023

Drug and non-drug therapies for HFpEF, the search for AF, and exercise as medicine are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. SGLT2 Inhibitors in HFpEF

Dapagliflozin Gets Expanded Heart Failure Indication in Europe https://www.medscape.com/viewarticle/988034

Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2206286

II. HFpEF and Heart Rate

Accelerated Pacing a Possible Strategy for Preserved-EF Heart Failure? https://www.medscape.com/viewarticle/987815

III. Stroke and AF

STROKE AF at 3 Years: High AF Rate After Atherosclerotic Stroke https://www.medscape.com/viewarticle/988076

Effect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease https://jamanetwork.com/journals/jama/fullarticle/2780490
Cryptogenic Stroke and Underlying Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/nejmoa1313600
Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT https://pubmed.ncbi.nlm.nih.gov/28329139/
Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke https://www.nejm.org/doi/full/10.1056/NEJMoa2101897

IV. Exercise as Medicine

Trending Clinical Topic: Exercise Prescription https://reference.medscape.com/viewarticle/985373

Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesityhttps://pubmed.ncbi.nlm.nih.gov/36716009/

Features

Could a Breakthrough in Heart Failure With Preserved Ejection Fraction Just Take a Change of Pace? https://www.medscape.com/viewarticle/988088

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Questions or feedback, please contact news@medscape.net

Feb 3 2023 This Week in Cardiology Feb 03, 2023

A possible major breakthrough in thinking about diastolic dysfunction and HFpEF, MRI scanning and cardiac devices, and AF and dementia are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. New Thinking in HFpEF

Accelerated Pacing a Possible Strategy for Preserved-EF Heart Failure? https://www.medscape.com/viewarticle/987815

- Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrillation in Patients With Preclinical and Overt Heart Failure With Preserved Ejection Fraction: The myPACE Randomized Clinical Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2801001

- Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction https://doi.org/10.1016/j.jacc.2021.08.073

- A Targeted Treatment Opportunity for HFpEF: Taking Advantage of Diastolic Tone https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056412

- Lenient versus Strict Rate Control in Patients with Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/nejmoa1001337

II. MRI and ICD Function

Legacy ICDs Exposed to MRI Still Shock, Pace as Needed https://www.medscape.com/viewarticle/987729

- Implantable Defibrillator System Shock Function, Mortality, and Cause of Death After Magnetic Resonance Imaging https://doi.org/10.7326/M22-2653

- 2017 HRS expert consensus statement on magnetic resonance imaging and radiation exposure in patients with cardiovascular implantable electronic devices https://pubmed.ncbi.nlm.nih.gov/28502708/

III. AF and Dementia

Atrial Fibrillation and Dementia: What Do We Know?

https://www.medscape.com/viewarticle/985900

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https://www.medscape.com/author/bob-harrington

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Jan 27 2023 This Week in Cardiology Jan 27, 2023

Exercise for AF, drugs have more than one effect, AI bots and the future of medicine, and the good and bad news about prognosis in HF are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. AF and Exercise

Aerobic Exercise Can Reduce AF Frequency, Severity: ACTIVE-AF https://www.medscape.com/viewarticle/957322
An Exercise and Physical Activity Program in Patients With Atrial Fibrillation: The ACTIVE-AF Randomized Controlled Trial https://www.jacc.org/doi/full/10.1016/j.jacep.2022.12.002
Early Rhythm-Control Therapy in Patients with Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa2019422

II. GLP-1 Inhibitors and Retinopathy

Eye Check Important Before Starting Semaglutide for Diabetes https://www.medscape.com/viewarticle/987418
Glucagon-like peptide 1-receptor agonists and A1c: Good for the heart but less so for the eyes? https://doi.org/10.1016/j.dsx.2022.102696

III. AI Bot Passes USMLEs

AI Bot ChatGPT Passes US Medical Licensing Exams Without Cramming – Unlike Students https://www.medscape.com/viewarticle/987549
Performance of ChatGPT on USMLE: Potential for AI-Assisted Medical 2 Education Using Large Language Models https://www.medrxiv.org/content/10.1101/2022.12.19.22283643v2.full.pdf
Tyler Cowen Comments -- GPT and my own career trajectory https://marginalrevolution.com/marginalrevolution/2023/01/gpt-and-my-own-career-trajectory.html

IV. HF Prognosis

Temporal trends in the incidence of malignancy in heart failure: a nationwide Danish study https://doi.org/10.1093/eurheartj/ehac797

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Questions or feedback, please contact news@medscape.net

Jan 20 2023 This Week in Cardiology Jan 20, 2023

The loop diuretic duels, adverse events during hospital admissions, BP accuracy, and, again, left main revascularization strategies (again) are the topics John Mandrola discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. TRANSFORM HF

Clarity on Torsemide vs Furosemide in HF: TRANSFORM-HF Published https://www.medscape.com/viewarticle/987128

• Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure https://jamanetwork.com/journals/jama/fullarticle/2800428

• RANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? https://jamanetwork.com/journals/jama/fullarticle/2800445

II. Adverse Events in the Hospital

Adverse Events Reported in One Quarter of Inpatient Admissions https://www.medscape.com/viewarticle/987091

• The Safety of Inpatient Health Care https://www.nejm.org/doi/full/10.1056/NEJMsa2206117

III. BP Accuracy

Experts Demand Validation of Automatic Blood Pressure Devices

https://www.medscape.com/viewarticle/987032

IV. Left Main Coronary Artery Disease

Real-World Examination of Revascularization Strategies for Left Main Coronary Disease in Ontario, Canada

https://doi.org/10.1016/j.jcin.2022.10.016

Management of Left Main Coronary Artery Disease in Nonemergent Settings: The Heart of Multidisciplinary Teamwork https://doi.org/10.1016/j.jcin.2022.11.024

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Questions or feedback, please contact news@medscape.net

Jan 13 2023 This Week in Cardiology Jan 13, 2023

FOURIER authors’ response, a possible practice-changing paper in electrophysiology, and the ATLAS and CAPLA trials are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. FOURIER Authors Respond

Recount of FOURIER Data Finds Higher Mortality With Evolocumab; Trialists Push Back https://www.medscape.com/viewarticle/986634

Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data https://bmjopen.bmj.com/content/12/12/e060172
Letter to the Editor RE: "Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data". BMJ Open https://bmjopen.bmj.com/content/12/12/e060172.responses#letter-to-the-editor-re-restoring-mortality-data-in-the-fourier-cardiovascular-outcomes-trial-of-evolocumab-in-patients-with-cardiovascular-disease-a-reanalysis-based-on-regulatory-data-bmj-open-2022123060172
Risk of selection bias assessment in the NINDS rt-PA stroke study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202115/
Methodological survey of missing outcome data in an alteplase for ischemic stroke meta-analysis https://doi.org/10.1111/ane.13656

II. A Potential Practice-Changing Paper in Cardiac Pacing

Novel 'Cure' May Avert Lead Extraction in CIED Pocket Infections https://www.medscape.com/viewarticle/986762

Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections https://doi.org/10.1016/j.jacc.2022.10.022
Treatment of Localized Implantable Cardiac Device Pocket Infections https://doi.org/10.1016/j.jacc.2022.11.018

III. ATLAS Trial

Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations https://doi.org/10.7326/M22-1566
Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/full/10.1056/NEJMoa1915932
Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/10.1056/NEJMc2034917

IV. CAPLA Published

CAPLA Shows Limits of Further Ablation Post PVI in Persistent AF https://www.medscape.com/viewarticle/986901

Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2800186
Catheter Ablation for Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2800200

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact

news@medscape.net

Jan 6 2023 This Week in Cardiology Jan 06, 2023

Damar Hamlin, obesity and semaglutide, Open Data and PCSK9 inhibitors, and TAVI vs SAVR trials are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Damar Hamlin

Five Thoughts on the Damar Hamlin Collapse

https://www.medscape.com/viewarticle/986550

II. Semaglutide and Obesity in Adolescents

FDA Approves Wegovy (Semaglutide) for Obesity in Teens 12 and Up

https://www.medscape.com/viewarticle/986403

• Once-Weekly Semaglutide in Adolescents with Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2208601

III. Open Data and PCSK9 inhibitors

Evolocumab Added to Statins Cuts CV Events in FOURIER Trial

https://www.medscape.com/viewarticle/877348

• Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data

https://bmjopen.bmj.com/content/12/12/e060172

• Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

https://www.nejm.org/doi/full/10.1056/nejmoa1615664

• PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction https://pubmed.ncbi.nlm.nih.gov/34252181/

• Bendary Tweet https://twitter.com/DrBendary/status/1609849852979986432?s=20&t=FDDhGIofS_HQ4jxf8aHwBA

IV. Open Data and TAVI vs SAVR Trials

Risk of Bias in Randomized Clinical Trials Comparing Transcatheter and Surgical Aortic Valve Replacement https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799937

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Dec 23, 2022, This Week in Cardiology Podcast Dec 23, 2022

The top ten stories of the year plus a few honorary mentions. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I Annual Wrap Ups on Medscape

- Mandrola’s Top 10 Cardiology Stories of 2022 https://www.medscape.com/viewarticle/985607

- 2022 in Review Through a Cardiology Lens https://www.medscape.com/viewarticle/984505

- Top Cardiology Trials of 2022 https://www.medscape.com/viewarticle/985647

II REVIVED BCIS2

- Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction https://www.nejm.org/doi/full/10.1056/nejmoa2206606

- PCI Fails in Stable Disease Again: REVIVED-BCIS https://www.medscape.com/viewarticle/979862

- PCI Fails to Beat OMT in Ischemic Cardiomyopathy: REVIVED-BCIS2 https://www.medscape.com/viewarticle/979853

III GUIDE HF

- Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01754-2

- CardioMEMS Remote HF Monitoring: Resist the Spin and FOMO https://www.medscape.com/viewarticle/970278

- GUIDE-HF: CardioMEMS-Guided Meds Fall Short in Mild to Moderate Heart Failure https://www.medscape.com/viewarticle/957390

IV DECAAF II

- Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation The DECAAF II Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2793452

- DECAAF II: AF, Fibrosis Ablation Technique Falls Short, but Signs of Hope https://www.medscape.com/viewarticle/957469

V DANCAVAS

- Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2208681

- DANCAVAS Misses Primary Endpoint but Hints at Benefit from Comprehensive CV Screening https://www.medscape.com/viewarticle/979854

- Judicious CVD Screening May Work in Men: DANCAVAS https://www.medscape.com/viewarticle/980153

- DANCAVAS: Might Cardiovascular Screening Extend Men's Lives? https://www.medscape.com/viewarticle/979632

VI SODIUM HF

- Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial https://doi.org/10.1016/S0140-6736(22)00369-5

- Low-Sodium Diet Did Not Cut Clinical Events in Heart Failure Trial https://www.medscape.com/viewarticle/971482

- Sodium Restriction in Heart Failure: Another Dogma Felled by Randomization https://www.medscape.com/viewarticle/971697

- SODIUM-HF Simplifies Message to Patients on Diet https://www.medscape.com/viewarticle/971547

VII STRONG-HF

- Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial https://doi.org/10.1016/S0140-6736(22)02076-1

- Rapidly, Fully Optimize HF Meds After Hospital Discharge: STRONG-HF https://www.medscape.com/viewarticle/983870

- STRONG HF: More Beats Less After Discharge for Heart Failure https://www.medscape.com/viewarticle/983698

VIII Health Insurance Access

- Health Care Access and Management of Cardiovascular Risk Factors Among Working-Age Adults With Low Income by State Medicaid Expansion Status https://doi.org/10.1001/jamacardio.2022.1282

- Medicaid Expansion: Good First Step, but No Panacea for CV Care https://www.medscape.com/viewarticle/975141

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Questions or feedback, please contact news@medscape.net

Dec 16, 2022 This Week in Cardiology Podcast Dec 16, 2022

BP control over the long term, omecamtiv mecarbil, incentives and Goodhart’s law, and open science are the topics John Mandrola, MD, covers in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Long-Term BP Control

- Final SPRINT Data Confirm Lower BP Is Better https://www.medscape.com/viewarticle/951572

- Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control https://jamanetwork.com/journals/jamacardiology/fullarticle/2797064

- Let's Not SPRINT to Judgment About New Blood Pressure Goals https://www.acpjournals.org/doi/full/10.7326/M15-3123

- Should We SPRINT Toward New Blood Pressure Goals or Let the Dust Settle? https://doi.org/10.1016/j.amjmed.2016.04.022

II. Omecamtiv Mecarbil

- FDA Panel Votes No on Omecamtiv Mecarbil for Heart Failure https://www.medscape.com/viewarticle/985593

- Omecamtiv Mecarbil Fails to Improve Exercise Capacity in HFrEF https://www.medscape.com/viewarticle/978355

- Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2025797

- Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction https://jamanetwork.com/journals/jama/fullarticle/2794362

- Effects of omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: the GALACTIC-HF trial https://doi.org/10.1093/eurheartj/ehac293

III. Measuring Quality of Care

- MIPS Quality Scores Don't Reflect Quality of Care: Study https://www.medscape.com/viewarticle/985396

- Association Between Individual Primary Care Physician Merit-based Incentive Payment System Score and Measures of Process and Patient Outcomes https://jamanetwork.com/journals/jama/article-abstract/2799153

- Pay for Performance When Slogans Overtake Science in Health Policy https://jamanetwork.com/journals/jama/fullarticle/2799177

- Goodhart's law https://en.wikipedia.org/wiki/Goodhart%27s_law

IV. Open Science

- Radial Artery Outlasts SVG as Second CABG Conduit, Cuts 5-Year Clinical Risk https://www.medscape.com/viewarticle/896122

- Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results https://doi.org/10.1177/2515245917747646

- Radial artery versus saphenous vein versus right internal thoracic artery for coronary artery bypass grafting https://academic.oup.com/ejcts/article/62/1/ezac345/6604735?login=false

- Do all roads lead to Rome? Critical reassessment of the individual patient meta-analysis on bypass grafts by Gaudino et al. https://doi.org/10.1093/ejcts/ezac564

- Editorial: Radial artery versus saphenous vein versus right internal thoracic artery for coronary artery bypass grafting: Different conduits or different trials? https://doi.org/10.1093/ejcts/ezac562

Features

- Mandrola’s Top 10 Cardiology Stories of 2022 https://www.medscape.com/viewarticle/985607

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Questions or feedback, please contact news@medscape.net

Dec 9, 2022 This Week in Cardiology Podcast Dec 09, 2022

Nudges, statins, AI, less-is-more in the ICU, myocarditis, exercise as medicine, and December in the hospital are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Nudges and Statin Prescribing

EHR Alerts to Both Doc and Patient May Boost Statin Prescribing

https://www.medscape.com/viewarticle/984944

Effect of Nudges to Clinicians, Patients, or Both to Increase Statin Prescribing

https://jamanetwork.com/journals/jamacardiology/article-abstract/2798971

Association of the Hospital Readmissions Reduction Program With Mortality Among Medicare Beneficiaries Hospitalized for Heart Failure, Acute Myocardial Infarction, and Pneumonia

https://jamanetwork.com/journals/jama/fullarticle/2719307

Lack of Efficacy of a Salience Nudge for Substituting Selection of Lower-Calorie for Higher-Calorie Milk in the Work Place https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488787/

II. AI and Chest X-Ray

Single Chest X-Ray Could Predict 10-Year CVD Risk

https://www.medscape.com/viewarticle/984910

III. BOX Trial

Shorter Fever Prevention Duration Effective After Cardiac Arrest

https://www.medscape.com/viewarticle/984852

Duration of Device-Based Fever Prevention after Cardiac Arrest

https://www.nejm.org/doi/10.1056/NEJMoa2212528

Oxygen Targets in Comatose Survivors of Cardiac Arrest

https://www.nejm.org/doi/full/10.1056/NEJMoa2208686

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

https://www.nejm.org/doi/full/10.1056/NEJMoa2208687

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

https://www.nejm.org/doi/full/10.1056/NEJMoa2032510

IV. Myocarditis

Mortality Higher in Myocarditis After Virus Than After COVID Vax

https://www.medscape.com/viewarticle/985045

Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

https://link.springer.com/article/10.1007/s00392-022-02129-5#Tab2

Myopericarditis After COVID-19 mRNA Vaccination Among Adolescents and Young Adults

https://jamanetwork.com/journals/jamapediatrics/fullarticle/2798866

Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis

https://www.jacc.org/doi/full/10.1016/j.jacc.2022.09.049

V. Exercise as Medicine

Just 8 Minutes of Exercise a Day Is All You Need

https://www.medscape.com/viewarticle/984684

Vigorous physical activity, incident heart disease, and cancer: how little is enough? https://doi.org/10.1093/eurheartj/ehac572

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

John M Mandrola, MD

Dec 2, 2022 This Week in Cardiology Podcast Dec 02, 2022

SGLT2 inhibitors, publishing choices, second and third order effects of interventions, decision support, and patient selection for preventive procedures are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. EMPA Kidney

- EMPA-Kidney Seals SGLT2 Inhibitors as 'Foundational' for CKD https://www.medscape.com/viewarticle/984439

- EMPA-Kidney Moves the Needle for SGLT2 Inhibitors in Kidney Disease https://www.medscape.com/viewarticle/983521

- Empagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/pdf/10.1056/NEJMoa2204233

- Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy https://www.nejm.org/doi/10.1056/NEJMoa1811744

- Dapagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2024816

- Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials https://doi.org/10.1016/S0140-6736(22)02074-8

II. Publishing Choices

- Motorcycle Rallies Linked to Spike in Organ Transplants https://www.medscape.com/viewarticle/984623

- Organ Donation and Transplants During Major US Motorcycle Rallies https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2798550

III. Second and Third Order Effects

- Heart Disease Deaths Spiked During COVID After 10-Year Decline https://www.medscape.com/viewarticle/984605

IV. Decision Support

- Patient App Aids Decisions on Anticoagulants: ENHANCE-AF https://www.medscape.com/viewarticle/984253

- A Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision‐Making Pathway https://www.ahajournals.org/doi/10.1161/JAHA.122.028562

V. Percutaneous Left Atrial Appendage Closure

- Consider Life Expectancy When Referring for LAA Closure? https://www.medscape.com/viewarticle/981117

- Transcatheter Left Atrial Appendage Occlusion: A Multi-Center Real Life Experience https://www.mdpi.com/2077-0383/11/23/6944

- Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/full/10.1016/j.jacep.2022.06.012

- Indications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.121.008418

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Nov 18, 2022, This Week in Cardiology Nov 18, 2022

AHA 2022, Part 2: IRONMAN, ECMO-CS, CTS-AMI, and PROGRESSIVE AF are the trials John Mandrola, MD, reviews in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Pushback on PROMINENT

Zimerman Thread: https://twitter.com/AndreZimerman/status/1593019800036708353

II. IRONMAN

IRONMAN Galvanizes Case for IV Iron Repletion in Heart Failure

https://www.medscape.com/viewarticle/984030

Is Iron Replacement in Heart Failure Worth the Trouble?

https://www.medscape.com/viewarticle/983622

- Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial https://doi.org/10.1016/S0140-6736(22)02083-9

III. ECMO-CS

Avoid Routine Early ECMO in Severe Cardiogenic Shock: ECMO-CS

https://www.medscape.com/viewarticle/983618

- Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062949

- Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock and Cardiac Arrest https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118.004905

IV. CTS-AMI

Chinese Herbal Medicine May Offer Benefits in STEMI: CTS-AMI

https://www.medscape.com/viewarticle/983619

V. PROGRESSIVE AF

First-Line AF Ablation Cuts Risk of Progression vs Drug Therapy

https://www.medscape.com/viewarticle/983882

Role of Ablation Type and Risk Factors in Paroxysmal AF: PROGRESSIVE-AF Interview https://www.medscape.com/viewarticle/983474

- Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation

https://www.nejm.org/doi/full/10.1056/nejmoa2029980

- Progression of Atrial Fibrillation after Cryoablation or Drug Therapy

https://www.nejm.org/doi/10.1056/NEJMoa2212540

- Natural History of Subclinical Atrial Fibrillation Detected by Implanted Loop Recorders

https://pubmed.ncbi.nlm.nih.gov/31779791/

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Nov 11, 2022 This Week in Cardiology Podcast Nov 11, 2022

AHA 2022 Part 1: ISCHEMIA-EXTEND, STRONG-HF, chlorthalidone vs HCTZ, experts vs practitioners; torsemide vs furosemide; and TG lowering are discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. AHA Meta-comments

II. ISCHEMIA-Extended

- ISCHEMIA-EXTEND: Conservative Stable CAD Management Holds Up https://www.medscape.com/viewarticle/983657

- Survival After Invasive or Conservative Management of Stable Coronary Disease https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062714

III. STRONG-HF

- Rapidly, Fully Optimize HF Meds After Hospital Discharge: STRONG-HF https://www.medscape.com/viewarticle/983870

- STRONG HF: More Beats Less After Discharge for Heart Failure https://www.medscape.com/viewarticle/983698

- Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial https://doi.org/10.1016/S0140-6736(22)02076-1

IV. DCP

- Diuretic Agents Equal to Prevent CV Events in Hypertension: DCP https://www.medscape.com/viewarticle/983608

- HCTZ vs Chlorthalidone -- A Win for Practicing Doctors and Science https://www.medscape.com/viewarticle/983614

V. TRANSFORM HF

- No Survival Advantage for Either Torsemide or Furosemide in HF: TRANSFORM-HF https://www.medscape.com/viewarticle/983611

VI. PROMINENT

- Triglyceride Lowering Fails to Show CV Benefit in Large Fibrate Trial https://www.medscape.com/viewarticle/983610

- Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://www.nejm.org/doi/full/10.1056/NEJMoa2210645

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Nov 4, 2022 This Week in Cardiology Podcast Nov 04, 2022

AF conversion in the ED, HRT, a shining example of evidence-based medicine and less-is-more, multimorbidity, and what’s coming at AHA are the topics John Mandrola, MD, covers in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. AF Conversion

- IV Potassium and Magnesium an Acute Treatment for AF? https://www.medscape.com/viewarticle/983137

- Association of Intravenous Potassium and Magnesium Administration With Spontaneous Conversion of Atrial Fibrillation and Atrial Flutter in the Emergency Department https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797474

II. HRT

- USPSTF Doesn't Change Postmenopausal Hormone Recommendations https://www.medscape.com/viewarticle/983349

- Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women https://doi.org/10.7326/0003-4819-117-12-1016

- Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal WomenPrincipal Results From the Women's Health Initiative Randomized Controlled Trial https://jamanetwork.com/journals/jama/fullarticle/195120

- Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal PersonsUS Preventive Services Task Force Recommendation Statement https://jamanetwork.com/journals/jama/fullarticle/2797867

- Menopausal Hormone Therapy for Prevention of Chronic Conditions https://jamanetwork.com/journals/jama/fullarticle/2797897

III. BP Targets After Stroke Intervention

- Intensive BP Lowering Harmful in Acute Ischemic Stroke: ENCHANTED2/MT https://www.medscape.com/viewarticle/983176

- Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial https://doi.org/10.1016/S0140-6736(22)01882-7

IV. Multimorbidity

- ACC Issues Guidance on Integrating ASCVD and Multimorbidity Care https://www.medscape.com/viewarticle/983123

- 2022 ACC Expert Consensus Decision Pathway for Integrating Atherosclerotic Cardiovascular Disease and Multimorbidity Treatment: A Framework for Pragmatic, Patient-Centered Care: A Report of the American College of Cardiology Solution Set Oversight Committee https://www.jacc.org/doi/10.1016/j.jacc.2022.08.754

V. AHA Preview

- AHA 2022 to Recapture In-Person Vibe but Preserve Global Reach https://www.medscape.com/viewarticle/983315

- Mandrola's Top 5 Picks From AHA 2022 Previewed https://www.medscape.com/viewarticle/983237

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Oct 28 2022 This Week in Cardiology Oct 28, 2022

ERASE AF follow-up, recreational drugs and AF, etripamil, misuse of science, and diabetes as a cardiovascular risk factor are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Follow-up on ERASE AF

II. Recreational Drugs

Four Commonly Abused Drugs Linked With Atrial Fibrillation

https://www.medscape.com/viewarticle/983052

III. Etripamil

RAPID: Positive Data for Etripamil Nasal Spray in Paroxysmal SVT

https://www.medscape.com/viewarticle/982787

- Milestone Pharmaceuticals Announces Positive Results from Phase 3 RAPID Clinical Trial of Etripamil Nasal Spray in Patients with Paroxysmal Supraventricular Tachycardia https://investors.milestonepharma.com/news-releases/news-release-details/milestone-pharmaceuticals-announces-positive-results-phase-3

IV. Misuse of Science

When Bad Actors Hijack Good Research

https://www.medscape.com/viewarticle/982936

- Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/31050775/

V. Diabetes as a Risk Factor

Diabetes Becoming Less Potent Risk Factor for CVD Events

https://www.medscape.com/viewarticle/982801

- Trends in the Association Between Diabetes and Cardiovascular Events, 1994-2019 https://jamanetwork.com/journals/jama/fullarticle/2797494

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Oct 21, 2022 This Week in Cardiology Podcast Oct 21, 2022

The ERASE AF ablation trial, left bundle pacing, finerenone, and perceptions of cardiology are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. AF Ablation

- Low-Voltage Myocardium-Guided Ablation Trial of Persistent Atrial Fibrillation https://evidence.nejm.org/doi/10.1056/EVIDoa2200141

- Approaches to Catheter Ablation for Persistent Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa1408288

- Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2793452

- Circumferential Pulmonary Vein Isolation Plus Low-Voltage Area Modification in Persistent Atrial Fibrillation: The STABLE-SR-II Trial https://www.jacc.org/doi/full/10.1016/j.jacep.2022.03.012

- Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2772281

- Hybrid Convergent Procedure for the Treatment of Persistent and Long-Standing Persistent Atrial Fibrillation https://www.ahajournals.org/doi/full/10.1161/CIRCEP.120.009288

II. Left Bundle Branch Area Pacing

- FDA OKs Medtronic Lead for Left Bundle Branch Pacing https://www.medscape.com/viewarticle/982577

- Left bundle branch area pacing outcomes: the multicentre European MELOS study https://academic.oup.com/eurheartj/article/43/40/4161/6671019

- Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy https://www.jacc.org/doi/full/10.1016/j.jacc.2022.07.019

- Early sudden distal conductor fracture of a stylet-driven lead implanted for left bundle branch area pacing https://doi.org/10.1016/j.hrcr.2022.10.004

- Repositioning and extraction of stylet-driven pacing leads with extendable helix used for left bundle branch area pacing https://pubmed.ncbi.nlm.nih.gov/33825263/

- Safety and Procedural Success of Left Atrial Appendage Exclusion With the Lariat Device https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2289126

III. Finerenone

- Finerenone Benefits T2D Across Spectrum of Renal Function https://www.medscape.com/viewarticle/982626

- Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes https://www.nejm.org/doi/10.1056/NEJMoa2110956

- Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis https://academic.oup.com/eurheartj/article/43/6/474/6433104

- Finerenone and Heart Failure Outcomes by Kidney Function/Albuminuria in Chronic Kidney Disease and Diabetes https://www.jacc.org/doi/10.1016/j.jchf.2022.07.013

IV. Perceptions of Cardiology

- IM Residents Rate Cardiology Low on Work-Life Balance https://www.medscape.com/viewarticle/982578

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Oct 14, 2022 This Week in Cardiology Podcast Oct 14, 2022

Chest pain evaluation in the ED, peer review, the NordICC trial, and a surgeon lost too early are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Chest Pain Consensus Pathway

- ACC Issues Guidance on ED Evaluation of Acute Chest Pain https://www.medscape.com/viewarticle/982302

- 2022 ACC Expert Consensus Decision Pathway on the Evaluation and Disposition of Acute Chest Pain in the Emergency Department: A Report of the American College of Cardiology Solution Set Oversight Committee https://www.jacc.org/doi/10.1016/j.jacc.2022.08.750

- 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001030#d20522356e1

II. Peer Review

- Big Name Researchers May Get Special Treatment, Limiting New Science https://www.medscape.com/viewarticle/982193

- Nobel and Novice: Author Prominence Affects Peer Review https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4190976

- Editorial peer review for improving the quality of reports of biomedical studies https://www.cochrane.org/MR000016/METHOD_editorial-peer-review-for-improving-the-quality-of-reports-of-biomedical-studies

III. NordICC

- Colonoscopy Lowers CRC Risk and Death, but Not by Much: NordICC https://www.medscape.com/viewarticle/982143

- Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death https://www.nejm.org/doi/full/10.1056/NEJMoa2208375

- The arrogance of preventive medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117852/

- Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2208681

IV. Domenico Pagano

- Surgeon Domenico Pagano Has Died, EACTS Announces https://www.medscape.com/viewarticle/982351

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Oct 7, 2022 This Week in Cardiology Oct 07, 2022

Post-PCI antiplatelet therapy, palliative care in patients with HF, Watchman information on hospital websites, and HCM in athletes are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Post-Stent Antiplatelet Therapy

SMART-CHOICE 3-Year Results Support Dropping Aspirin After PCI

https://www.medscape.com/viewarticle/981741

Long-term Effects of P2Y12 Inhibitor Monotherapy After Percutaneous Coronary Intervention https://jamanetwork.com/journals/jamacardiology/fullarticle/2796902
The Smart(est) Choice for Dual Antiplatelet Therapy is a Patient-Directed One https://jamanetwork.com/journals/jamacardiology/fullarticle/2796904
Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention https://jamanetwork.com/journals/jama/fullarticle/2736564

II. Palliative Care in HF

Home-Based Palliative Care Improves Heart Failure Outcomes https://www.medscape.com/viewarticle/981715

Regional collaborative home-based palliative care and health care outcomes among adults with heart failure https://doi.org/10.1503/cmaj.220784

III. Watchman Info on Hospital Websites

Concern Over US Hospital Patient Information on LAA Closure https://www.medscape.com/viewarticle/981961

Analysis of Patient-Focused Information About Left Atrial Appendage Occlusion on US Hospital Web Pages https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2797102

IV. HCM and Exercise in Athletes

Athletes With Mild HCM Can Likely Continue Competitive Sports https://www.medscape.com/viewarticle/981782

Impact of Exercise on Outcomes and Phenotypic Expression in Athletes With Nonobstructive Hypertrophic Cardiomyopathy https://www.jacc.org/doi/full/10.1016/j.jacc.2022.08.715
A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD) https://pubmed.ncbi.nlm.nih.gov/24126876/

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Sep 30, 2022 This Week in Cardiology Podcast Sep 30, 2022

Pulmonary embolism, coffee, when DOACs don’t work, lipoprotein (a), and the marginal benefits of current CV therapy are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Pulmonary Embolism

- Positive Data on Thrombectomy Catheter That Avoids Thrombolytics in Acute PE https://www.medscape.com/viewarticle/981322

- Acute Outcomes for the Full US Cohort of the FLASH Mechanical Thrombectomy Registry in Pulmonary Embolism https://eurointervention.pcronline.com/article/acute-outcomes-for-the-full-us-cohort-of-the-flash-mechanical-thrombectomy-registry-in-pulmonary-embolism

- PEERLESS Study https://clinicaltrials.gov/ct2/show/NCT05111613

- Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism (HI-PEITHO) https://clinicaltrials.gov/ct2/show/NCT04790370

- A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism: The FLARE Study https://doi.org/10.1016/j.jcin.2018.12.022

II. Coffee Again

- Coffee Linked to Reduced Cardiovascular Disease and Mortality https://www.medscape.com/viewarticle/981518

Enough With the Coffee Research and Other Distractions https://www.medscape.com/viewarticle/883709

- The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank https://doi.org/10.1093/eurjpc/zwac189

III. DOAC and Mechanical Valves

- PROACT Xa Trial of Apixaban With On-X Heart Valve Stopped https://www.medscape.com/viewarticle/981644

- Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial https://investors.artivion.com/news-releases/news-release-details/artivion-follows-recommendation-stop-proact-xa-clinical-trial

- PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban https://clinicaltrials.gov/ct2/show/NCT04142658

- Dabigatran versus Warfarin in Patients with Mechanical Heart Valves https://www.nejm.org/doi/full/10.1056/nejmoa1300615

IV. Lipoprotein(a)

- Aspirin Primary Prevention Benefit in Those With Raised Lp(a)? https://www.medscape.com/viewarticle/981602

- Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes https://www.jacc.org/doi/full/10.1016/j.jacc.2022.07.027

- A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women https://www.nejm.org/doi/full/10.1056/nejmoa050613

- Effect of Aspirin on Disability-free Survival in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1800722

- Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1805819

- Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1803955

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Sep 23, 2022 This Week in Cardiology Podcast Sep 23, 2022

In this week’s podcast, John Mandrola, MD, discusses the PROTECTED TAVR trial, renal denervation, left atrial appendage closure and deprescribing aspirin.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I Cerebral Embolic Protection After TAVI

- Clear Stroke Benefit Eludes Embolic Protection: PROTECTED TAVR https://www.medscape.com/viewarticle/980978

- Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement https://www.nejm.org/doi/10.1056/NEJMoa2204961

- Protection Against Cerebral Embolism During Transcatheter Aortic Valve Replacement https://doi.org/10.1016/j.jacc.2016.10.023

- Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa1908655

- Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2208681

- Randomised Trial Of Intravenous Streptokinase, Oral Aspirin, Both, Or Neither Among 17 187 Cases Of Suspected Acute Myocardial Infarction: Isis-2 https://doi.org/10.1016/S0140-6736(88)92833-4

II Renal Denervation

- Legacy of Neutral Renal Denervation Trial Recast by Long-term Outcomes: SYMPLICITY HTN-3 https://www.medscape.com/viewarticle/981062

- Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial https://doi.org/10.1016/S0140-6736(22)01787-1

- A systematic review, meta-analysis, and meta regression of the sham controlled renal denervation randomized controlled trials https://doi.org/10.1016/j.tcm.2022.05.009

- Legacy of Neutral Renal Denervation Trial Recast by Long-term Outcomes: SYMPLICITY HTN-3 https://www.medscape.com/viewarticle/981062

- A Controlled Trial of Renal Denervation for Resistant Hypertension https://www.nejm.org/doi/10.1056/NEJMoa1402670

III Percutaneous Left Atrial Appendage Occlusion (LAAO)

- Amulet, Watchman 2.5 LAAO Outcomes Neck and Neck at 3 Years https://www.medscape.com/viewarticle/981199

- Consider Life Expectancy When Referring for LAA Closure? https://www.medscape.com/viewarticle/981117

- Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/full/10.1016/j.jacep.2022.06.012

IV Deprescribing Aspirin

- Deprescribing Aspirin for Warfarin Patients May Reduce Bleeding https://www.medscape.com/viewarticle/981243

- Assessment of an Intervention to Reduce Aspirin Prescribing for Patients Receiving Warfarin for Anticoagulation https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796492

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Sept 16, 2022 This Week in Cardiology Podcast Sep 16, 2022

The safety of very low LDL-C, the win-ratio analytic method, sacubitril/valsartan, SGLT2 inhibitors, and percutaneous left atrial appendage closure are discussed in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I PCSK9I

Evolocumab Benefits Accrue With Longer Follow-up: FOURIER OLE https://www.medscape.com/viewarticle/979950

- Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease https://www.nejm.org/doi/full/10.1056/nejmoa1615664

- Long-Term Evolocumab in Patients with Established Atherosclerotic Cardiovascular Disease https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061620

II Analytic Methods and Re-Analysis of Old Trials

- PARADISE-MI Results Obscured As Post Hoc Analysis Finds Flaws https://www.medscape.com/viewarticle/980776

- Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://www.nejm.org/doi/10.1056/NEJMoa2104508

- Impact of Sacubitril/Valsartan Versus Ramipril on Total Heart Failure Events in the PARADISE-MI Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057429

- The Year’s Most Important Study Adds to Uncertainty in Science https://www.medscape.com/viewarticle/904286

III SGLT2i Post MI

- Early Signal of Benefit for Empagliflozin in Acute MI: EMMY https://www.medscape.com/viewarticle/980180

- Empagliflozin in acute myocardial infarction: the EMMY trial https://doi.org/10.1093/eurheartj/ehac494

IV Percutaneous Left Atrial Appendage Closure

- Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/10.1016/j.jacep.2022.06.012

- Cost‐Effectiveness of Left Atrial Appendage Closure for Stroke Reduction in Atrial Fibrillation: Analysis of Pooled, 5‐Year, Long‐Term Data https://www.ahajournals.org/doi/10.1161/JAHA.118.011577

- Baseline Comorbidities And Bleeding Events Of Patients Undergoing Percutaneous Left Atrial Appendage Occlusion Among Medicare Beneficiaries https://www.jacc.org/doi/10.1016/S0735-1097%2822%2901158-5

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Sep 9, 2022 This Week in Cardiology Podcast Sep 09, 2022

A potential new anticoagulant, surveillance stress testing, a trial misinterpretation, an old diuretic, and AI in cardiology are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Factor XI inhibitors

- Factor XIa Inhibitor After MI, Stroke Encouraging in Early Phase 2 Studies https://www.medscape.com/viewarticle/979942

- AXIOMATIC-SSP: Cautious Optimism on Factor XI Inhibitor in Stroke https://www.medscape.com/viewarticle/979860

II. Surveillance Stress Testing

- No Benefit of Routine Stress Test POST-PCI in High-Risk Patients https://www.medscape.com/viewarticle/979866

- Routine Functional Testing or Standard Care in High-Risk Patients after PCI https://www.nejm.org/doi/full/10.1056/NEJMoa2208335

III. New Diuretic for Acute Heart Failure

- Vintage Drug Atop IV Loop Diuretics Boosts Decongestion in ADHF: ADVOR https://www.medscape.com/viewarticle/979851

- Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://www.nejm.org/doi/full/10.1056/NEJMoa2203094

IV. AI in Cardiology

- In Blinded Trial, Artificial Intelligence Beats Sonographers for Echo Accuracy https://www.medscape.com/viewarticle/979857

- Video-based AI for beat-to-beat assessment of cardiac function https://www.nature.com/articles/s41586-020-2145-8

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Sep 2 2022 This Week in Cardiology Podcast Sep 02, 2022

A second ESC review covering REVIVED, the DANCAVAS CV screening trial, DELIVER on dapagliflozin in HF with mildly reduced EF, and the INVICTUS trial of rivaroxaban in rheumatic heart disease. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I REVIVED BCIS

- PCI Fails to Beat OMT in Ischemic Cardiomyopathy: REVIVED-BCIS2 https://www.medscape.com/viewarticle/979853

- Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction https://www.nejm.org/doi/full/10.1056/NEJMoa2206606

- Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction https://www.nejm.org/doi/full/10.1056/nejmoa1100356

II DANCAVAS

- DANCAVAS Misses Primary Endpoint but Hints at Benefit from Comprehensive CV Screening https://www.medscape.com/viewarticle/979854

- Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2208681

- Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1608029

III DELIVER Trial

- Dapagliflozin's HFpEF Benefit Recasts Heart Failure Treatment: DELIVER https://www.medscape.com/viewarticle/979855

- Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2206286

- Empagliflozin in Heart Failure with a Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

- SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials https://doi.org/10.1016/S0140-6736(22)01429-5

IV Rheumatic Heart Disease

- Rivaroxaban Outmatched by VKAs for AF in Rheumatic Heart Disease https://www.medscape.com/viewarticle/979861

- Rivaroxaban in Rheumatic Heart Disease–Associated Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa2209051

- Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve https://www.nejm.org/doi/full/10.1056/NEJMoa2029603

- Outcomes of Direct Oral Anticoagulants in Patients With Mitral Stenosis https://www.jacc.org/doi/full/10.1016/j.jacc.2018.12.047

Features:

- Do SGLT2 Inhibitors DELIVER in All Patients With Heart Failure? https://www.medscape.com/viewarticle/979852

- PCI Fails in Stable Disease Again: REVIVED-BCIS https://www.medscape.com/viewarticle/979862

- DANCAVAS: Might Cardiovascular Screening Extend Men's Lives? https://www.medscape.com/viewarticle/979632

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Aug 26, 2022 This Week in Cardiology Podcast Aug 26, 2022

Early rhythm control in AF, treating coronary artery disease before transcatheter aortic valve implantation, and an ESC 2022 preview are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Early Rhythm Control

- Early AF Rhythm-Control Advantage Climbs With Comorbidity Burden: EAST-AFNET4 https://www.medscape.com/viewarticle/979627

- Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden https://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.122.060274

Early Rhythm-Control Therapy in Patients with Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa2019422

II. CAD and Aortic Stenosis

- No Survival Gains Seen From Pre-TAVR PCI of Complex CAD https://www.medscape.com/viewarticle/979408

- The Effect of Coronary Lesion Complexity and Preprocedural Revascularization on 5-Year Outcomes After TAVR https://doi.org/10.1016/j.jcin.2022.06.019

- Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta‐Analysis https://www.ahajournals.org/doi/10.1161/JAHA.117.005960

- ACTIVATION (PercutAneous Coronary inTervention prIor to transcatheter aortic Valve implantaTION): A Randomized Clinical Trial https://www.jacc.org/doi/full/10.1016/j.jcin.2021.06.041

III. ESC Trials

- Mandrola Previews His Top 5 Trials From ESC 2022 https://www.medscape.com/viewarticle/979560

TIME

- Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension https://pubmed.ncbi.nlm.nih.gov/35983870/

- Empirical Evaluation of Very Large Treatment Effects of Medical Interventions https://jamanetwork.com/journals/jama/fullarticle/1386610

SECURE

- Polypill Strategy in Secondary Cardiovascular Prevention http://www.nejm.org/doi/full/10.1056/NEJMoa2208275

Aug 19, 2022 This Week in Cardiology Podcast Aug 19, 2022

The obesity paradox in AF and paradoxes in general, digital health gets whacked again, and direct-to-consumer ads are the topics discussed by John Mandrola, MD in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Collider Bias and the Obesity Paradox

- 'Obesity Paradox' in Atrial Fibrillation Challenged as Mortality Climbs With BMI https://www.medscape.com/viewarticle/979150

- Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF https://openheart.bmj.com/content/9/2/e002038

- Collider bias https://catalogofbias.org/biases/collider-bias/

- Pediatric obesity appears to lower the risk of diabetes if selection bias is ignored https://pubmed.ncbi.nlm.nih.gov/29374028/

- Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2480484

II. Digital Health

- Blood Pressure Smartphone App Fails to Beat Standard Self-Monitoring https://www.medscape.com/viewarticle/979341

- Effectiveness of Standard vs Enhanced Self-measurement of Blood Pressure Paired With a Connected Smartphone Application https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2794971

III. Direct-to-Consumer Ads

- Does DTC Heart Drug Advertising Discourage Lifestyle Changes? https://www.medscape.com/viewarticle/979404

- Association of Direct-to-Consumer Advertising of Prescription Drugs With Consumer Health-Related Intentions and Beliefs Among Individuals at Risk of Cardiovascular Disease https://jamanetwork.com/journals/jama-health-forum/fullarticle/2794995

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Aug 12, 2022 This Week in Cardiology Podcast Aug 12, 2022

AF screening; sodium, potassium, BP, and CV outcomes; drug prices; and cardio-respiratory fitness are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. AF Screening

- Using Wearable Devices to Detect AF Is 'Cost Effective' https://www.medscape.com/viewarticle/978861

- Cost-effectiveness of Screening for Atrial Fibrillation Using Wearable Devices https://jamanetwork.com/journals/jama-health-forum/fullarticle/2794835

- Screening for Atrial Fibrillation in Asymptomatic Older Adults https://www.nejm.org/doi/full/10.1056/NEJMclde2203726

II. Salt Substitutes

- More Evidence Salt Substitutes Lower Risk of CVD and Death https://www.medscape.com/viewarticle/978999

- Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis https://heart.bmj.com/content/early/2022/07/21/heartjnl-2022-321332

- Effect of Salt Substitution on Cardiovascular Events and Death https://www.nejm.org/doi/10.1056/NEJMoa2105675

- Settling the controversy of salt substitutes and stroke: sodium reduction or potassium increase? https://doi.org/10.1093/eurheartj/ehac160

- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia https://www.nejm.org/doi/full/10.1056/nejmoa1812792

- Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention https://www.nejm.org/doi/full/10.1056/nejmoa0807611

III. Drug Prices

- House Could Soon Give Biden Win on Medicare Drug Negotiations, Insulin Costs https://www.medscape.com/viewarticle/978988

IV. Fitness is Under-rated

- Cardiorespiratory Fitness Key to Longevity for All? https://www.medscape.com/viewarticle/978854

- Cardiorespiratory Fitness and Mortality Risk Across the Spectra of Age, Race, and Sex https://www.jacc.org/doi/full/10.1016/j.jacc.2022.05.031

- Cardiorespiratory fitness, obesity and left atrial function in patients with atrial fibrillation https://doi.org/10.1016/j.ijcha.2022.101083

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Aug 5, 2022 This Week in Cardiology Podcast Aug 05, 2022

Hyperkalemia in heart failure, CV health in America, primary prevention ICDs, and a debate about posters at medical meetings are the topics discussed by John Mandrola, MD in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I. Hyperkalemia in Heart Failure

- DIAMOND: Adding Patiromer Helps Optimize HF Meds, Foils Hyperkalemia https://www.medscape.com/viewarticle/971616

- Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial https://doi.org/10.1093/eurheartj/ehac401

- Potassium Binders for Patients With Heart Failure? The Real Enlightenment of the DIAMOND Trial https://doi.org/10.1093/eurheartj/ehac399

- The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure https://www.nejm.org/doi/full/10.1056/nejm199909023411001

- Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms https://www.nejm.org/doi/full/10.1056/nejmoa1009492

- Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial https://pubmed.ncbi.nlm.nih.gov/21208974/

II. CV Health in America

- ‘Staggering’ CVD Rise Projected in US, Especially in Minorities https://www.medscape.com/viewarticle/978366

- Cardiovascular Disease Projections in the United States Based on the 2020 Census Estimates https://www.jacc.org/doi/10.1016/j.jacc.2022.05.033

III. Primary Prevention ICDs in Modern Era

- Do ICDs Still ‘Work’ in Primary Prevention Given Today’s Recommended HF Meds? https://www.medscape.com/viewarticle/978254

- Guideline-Directed Medical Therapy and the Risk of Death in Primary Prevention Defibrillator Recipients https://doi.org/10.1016/j.jacep.2022.05.001

- Declining Risk of Sudden Death in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1609758

- Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1608029

IV. Medical Meetings and Posters

- As Digital Posters Take Over, Traditionalists Push Back https://www.medscape.com/viewarticle/978384

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Questions or feedback, please contact news@medscape.net

July 29, 2022 This Week in Cardiology Jul 29, 2022

A big new HF and EP trial, doctors and probability, LV assist devices in cardiogenic shock, vitamin D, and exercise in PAD are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Left vs Left RCT

Taking Cardiac Pacing From Boring to Super-Cool https://www.medscape.com/viewarticle/973615

Conduction-System Pacing Shines vs BiV Pacing for CRT in Early Studies https://www.medscape.com/viewarticle/974173

• Baylor led research awarded $31 Million for Resynchronization Therapy in Patients with Heart Failure https://www.bcm.edu/news/baylor-led-research-awarded-31-million-for-resynchronization-therapy-in-patients-with-heart-failure

II. Probability and Conjunction Fallacy

Is What You Call Probable...Impossible?

https://www.medscape.com/viewarticle/976451

• Analysis of Physicians’ Probability Estimates of a Medical Outcome Based on a Sequence of Events

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793624

III. LV Assist Devices

Impella Pump for MI With Cardiogenic Shock Again Fares Poorly vs IABP in Study

https://www.medscape.com/viewarticle/977994

• Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2794390

• Intravascular Microaxial Left Ventricular Assist Device for Acute Myocardial Infarction With Cardiogenic Shock—A Call for Evidence of Benefit https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2794394

• Intra-aortic Balloon Pump Therapy for Acute Myocardial InfarctionA Meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2210888

IV. Vitamin D

Vitamin D Supplements Do Not Lower Risk of Fractures

https://www.medscape.com/viewarticle/978108

Why Is Vitamin D Hype So Impervious to Evidence? https://www.medscape.com/viewarticle/968682

• Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults

https://www.nejm.org/doi/full/10.1056/NEJMoa2202106

V. Peripheral Artery Disease

For Patients With Peripheral Artery Disease, Pain Can Be Gain

https://www.medscape.com/viewarticle/978053

• Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial

https://www.ahajournals.org/doi/10.1161/JAHA.121.025063

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July 22, 2022 This Week in Cardiology Podcast Jul 22, 2022

Therapeutic fashion and conduction system pacing, early rhythm control in AF, statins in CKD, and salt intake in HF are the topics discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Therapeutic Fashion and Conduction System Pacing

- Medical Necessity vs Therapeutic Fashion: How Evidence-Based Is Your Field of Medicine? https://www.medscape.com/viewarticle/977358

- Conduction System Pacing Noninferior to Biventricular Pacing for HF With Wide QRS https://www.medscape.com/viewarticle/971740

- His Corrective Pacing or Biventricular Pacing for Cardiac Resynchronization in Heart Failure https://www.jacc.org/doi/full/10.1016/j.jacc.2019.04.026

II – Early Rhythm Control

- Benefit of Early Rhythm Control Questioned in Newly Diagnosed Atrial Fibrillation https://www.medscape.com/viewarticle/977584

- Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy https://doi.org/10.1016/j.jacc.2022.04.058

- Early Rhythm-Control Therapy in Patients with Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa2019422

III – Statins and CKD

- Rosuvastatin Again Linked With Risks to Kidneys https://www.medscape.com/viewarticle/977646

- Association of Rosuvastatin Use with Risk of Hematuria and Proteinuria https://doi.org/10.1681/ASN.2022020135

- Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis https://www.nejm.org/doi/10.1056/NEJMoa043545

- Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis https://www.nejm.org/doi/full/10.1056/nejmoa0810177

IV – Sodium and HF

- Overly Tight Sodium Restriction May Worsen HFpEF Outcomes https://www.medscape.com/viewarticle/977441

- Salt restriction and risk of adverse outcomes in heart failure with preserved ejection fraction https://heart.bmj.com/content/early/2022/06/07/heartjnl-2022-321167

- Spironolactone for Heart Failure with Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/nejmoa1313731

- Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial https://doi.org/10.1016/S0140-6736(22)00369-5

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July 15, 2022 This Week in Cardiology Podcast Jul 15, 2022

The LIFE study, multimorbidity and evidence translation, cardiac arrest and therapeutic fashion, diabetes and cardiology, and EP cuts are the topics John Mandrola, MD, tackles in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – LIFE Study and Substudy

- LIFE: ARNI Does Not Best Valsartan in Advanced Heart Failure https://www.medscape.com/viewarticle/952681

- Tolerability of Sacubitril/Valsartan in Patients With Advanced Heart Failure: Analysis of the LIFE Trial Run-In https://www.jacc.org/doi/10.1016/j.jchf.2022.04.013

- Effect of Treatment With Sacubitril/Valsartan in Patients With Advanced Heart Failure and Reduced Ejection FractionA Randomized Clinical Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2785700

II – Early Angiography and Therapeutic Fashion

- Emergency Angiography for Cardiac Arrest Without ST Elevation? https://www.medscape.com/viewarticle/975434

- Emergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac ArrestResults of the Randomized, Multicentric EMERGE Trial https://jamanetwork.com/journals/jamacardiology/article-abstract/2793310

- Immediate Coronary Angiography in Survivors of Out-of-Hospital Cardiac Arrest https://www.nejm.org/doi/full/10.1056/NEJM199706053362302

- Coronary Angiography after Cardiac Arrest without ST-Segment Elevation https://www.nejm.org/doi/10.1056/NEJMoa1816897

- Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.049569

- Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation https://www.nejm.org/doi/10.1056/NEJMoa2101909

- Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic review and meta-analysis https://www.jclinepi.com/article/S0895-4356(22)00100-7/fulltext

III – Diabetes and Cardiology

- Medicare Advantage Tied to Less Use of Pricey Diabetes Drugs https://www.medscape.com/viewarticle/977181

- Diabetes Care Among Older Adults Enrolled in Medicare Advantage Versus Traditional Medicare Fee-For-Service Plans: The Diabetes Collaborative Registry https://doi.org/10.2337/dc21-1178

IV – EP Cuts

- EP Ablation Rate Changes in 2022 Physician Fee Schedule https://www.acc.org/Latest-in-Cardiology/Articles/2021/11/18/01/44/EP-Ablation-Rate-Changes-in-2022-Physician-Fee-Schedule

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Jul 8, 2022 This Week in Cardiology Podcast Jul 08, 2022

On this week’s podcast, John Mandrola, MD discusses fish oil, America’s heart health, pharmacists and prescribing and statins This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - Fish Oil

- New Biomarker Data Add to Concerns Over REDUCE-IT Trial https://www.medscape.com/viewarticle/976490

- Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.059410

- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia https://www.nejm.org/doi/full/10.1056/nejmoa1812792

- Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular RiskThe STRENGTH Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2773120

- Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial https://academic.oup.com/eurheartj/article/41/40/3925/5898836

II - US Heart Health

- New AHA Checklist: Only 1 in 5 Adults Have Optimal Heart Health https://www.medscape.com/viewarticle/976519

- Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078

- Status of Cardiovascular Health in US Adults and Children Using the American Heart Association's New "Life's Essential 8" Metrics: Prevalence Estimates from the National Health and Nutrition Examination Survey (NHANES), 2013-2018 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060911

III - Pharmacist Prescribing

- Paxlovid Is Here: A Pharmacist's Prescribing Pearls https://www.medscape.com/viewarticle/973260

- Coronavirus (COVID-19) Update: FDA Authorizes Pharmacists to Prescribe Paxlovid with Certain Limitations https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-pharmacists-prescribe-paxlovid-certain-limitations

IV - Statin Eligibility

- New European Guidelines ‘Drastically’ Reduce Statin Eligibility https://www.medscape.com/viewarticle/976715

- Statin Eligibility for Primary Prevention of Cardiovascular Disease According to 2021 European Prevention Guidelines Compared With Other International Guidelines https://jamanetwork.com/journals/jamacardiology/article-abstract/2793729

- Time to Revisit Using 10-Year Risk to Guide Statin Therapy https://jamanetwork.com/journals/jamacardiology/article-abstract/2793732

- Mendelian randomization studies: using naturally randomized genetic data to fill evidence gaps https://doi.org/10.1097/mol.0000000000000247

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https://www.medscape.com/author/bob-harrington

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June 17, 2022 This Week in Cardiology Podcast Jun 17, 2022

Statin Intolerance, external validity of trials, contrast shortage, and expansion of cardiology into diabetes and nephrology are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I - Statin Intolerance

- New National Lipid Association Statement on Statin Intolerance https://www.medscape.com/viewarticle/975674

- What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice. https://academic.oup.com/eurjpc/article/21/4/464/5926070

- Unblinded and Blinded N-of-1 Trials Versus Usual Care: A Randomized Controlled Trial to Increase Statin Uptake in Primary Care. https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.120.007793

- Role of Blinding in N-of-1 Trials https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.122.008914

- N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173

II - External Validity

- Is Paxlovid, the Covid Pill, Reaching Those Who Most Need It? The Government Won't Say https://www.medscape.com/viewarticle/973906

- Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2118542

- PFE Press Release on EPIC SR https://www.pfizer.com/news/press-release/press-release-detail/pfizer-reports-additional-data-paxlovidtm-supporting

III - Contrast Shortage

- Global Contrast Media Shortage Blamed on COVID Lockdown in China https://www.medscape.com/viewarticle/973810

IV - Cardiology Expands

- Experts Elevate New Drugs for Diabetic Kidney Disease https://www.medscape.com/viewarticle/975724

- SGLT2 Inhibitors Cut AFib Risk in Real-Word Analysis https://www.medscape.com/viewarticle/975542

- Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2025845

- Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/nejmoa2110956

Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine

The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

June 10, 2022 This Week in Cardiology Podcast Jun 10, 2022

More ISCHEMIA controversy, health Insurance and CV outcomes, testosterone, and flawed observational studies are the topics discussed by John Mandrola, MD in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – More Ischemia Controversy

- Data Concerns Mount Despite ISCHEMIA Substudy Correction https://www.medscape.com/viewarticle/974974

- ISCHEMIA Substudy Data Just Don't Add Up, Cardiac Surgeons Say https://www.medscape.com/viewarticle/974107

- Initial Invasive or Conservative Strategy for Stable Coronary Disease https://www.nejm.org/doi/full/10.1056/nejmoa1915922

- Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.049755

- Link to Bakaeen and Sabik Second letter (agree to terms to download the letter): https://protect-us.mimecast.com/s/nfDdCwp5G6HLjLO9GHV9Cnm?domain=wetransfer.com

II – Health Insurance and CV outcomes

- Medicaid Expansion: Good First Step, but No Panacea for CV Care https://www.medscape.com/viewarticle/975141

- Health Care Access and Management of Cardiovascular Risk Factors Among Working-Age Adults With Low Income by State Medicaid Expansion Status https://jamanetwork.com/journals/jamacardiology/article-abstract/2793120

- Rand Link https://www.rand.org/pubs/reports/R3055.html

- The Oregon Health Insurance Experiment https://www.healthaffairs.org/do/10.1377/hpb20150716.236899/full/

- Effect of Health Insurance in India: A Randomized Controlled Trial https://www.nber.org/papers/w29576

III – Testosterone

- Jury Still Out on Cardiovascular Safety of Testosterone https://www.medscape.com/viewarticle/975273

- Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis https://doi.org/10.1016/S2666-7568(22)00096-4

- Adverse events associated with testosterone administration. https://www.nejm.org/doi/full/10.1056/NEJMoa1000485

IV – Voting and Mortality

- Blue Counties Enjoy Dramatic Mortality Edge https://www.medscape.com/viewarticle/975217

- Political environment and mortality rates in the United States, 2001-19: population based cross sectional analysis https://www.bmj.com/content/377/bmj-2021-069308

Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine

The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

June 3, 2022 This Week in Cardiology Podcast Jun 03, 2022

Devices for HF, Twitter for disseminating science, HDL levels, and dubious post-hoc studies are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Interatrial Shunts for HF

- Interatrial Shunt in HF Hints at Heart Structural, Functional Benefits https://www.medscape.com/viewarticle/974776

- Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial https://doi.org/10.1016/S0140-6736(22)00016-2

- Reducing Lung CongestIon Symptoms in Advanced Heart Failure (RELIEVE-HF) https://clinicaltrials.gov/ct2/show/NCT03499236

II – Twitter for Science Communication

- Twitter Promotion Boosts Visibility, Citation for CV Research https://www.medscape.com/viewarticle/974653

- Twitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study https://doi.org/10.1093/eurheartj/ehac150

- A Randomized Trial of Social Media From Circulation https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.013509

III – HDL Level

- Very High HDL-C: Too Much of a Good Thing? https://www.medscape.com/viewarticle/974651

- Association Between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-risk Populations https://jamanetwork.com/journals/jamacardiology/article-abstract/2792282

- Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889017/

IV – Dubious Sub-Studies: Omecamtiv Mecarbil

- Myosin Inhibitor May Benefit Data-Deprived Patients With Heart Failure and Low Blood Pressure https://www.medscape.com/viewarticle/974960

- Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2025797

- METEORIC-HF: Omecamtiv Mecarbil Does Not Improve Exercise Capacity in HFrEF Patients https://www.acc.org/Latest-in-Cardiology/Articles/2022/04/02/13/22/Sun-945am-METEORIC-HF-acc-2022

- Effects of Omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: the GALACTIC-HF trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac293/6590348

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Questions or feedback, please contact news@medscape.net

May 6, 2022 This Week in Cardiology May 06, 2022

HRS meeting presentations: conduction system pacing, AF in the ED, a possible new treatment for vagal bradycardia, and women in EP are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I – HRS Comments

II – Conduction System Pacing

Conduction System Disease Recast as Preventive Therapy Target

https://www.medscape.com/viewarticle/973488

• Rescue Left Bundle Branch Area Pacing in Coronary Venous Lead Failure or Non-response to Biventricular Pacing: Results From International LBBAP Collaborative Study Group

https://doi.org/10.1016/j.hrthm.2022.04.024

• Clinical Outcomes Of Conduction System Pacing Compared To Biventricular Pacing In Patients Requiring Cardiac Resynchronization Therapy

https://doi.org/10.1016/j.hrthm.2022.04.023

III – Emergency Triage of AF

Early Arrhythmia-Specialist Consult, Ordered in the ER, a Boon to AF Outcomes: ER2EP Study

https://www.medscape.com/viewarticle/973250

• ClinicalTrials.gov Reference

https://clinicaltrials.gov/ct2/show/NCT04476524

• George Bernard Shaw Reference:

https://jamanetwork.com/journals/jama/fullarticle/2623628

IV – Cardioneural Ablation

Can Ablation Abolish Vasovagal Syncope? Early Series Promising

https://www.medscape.com/viewarticle/973346

V – Women in EP

Why Are Numbers of Women, Minorities So Low in Cardiac EP?

https://www.medscape.com/viewarticle/972968

• Temporal and geographical trends in women operators of electrophysiology procedures in the United States

https://doi.org/10.1016/j.hrthm.2022.02.015

• Quantification of Female and Underrepresented Minority Applicants to Clinical Cardiac Electrophysiology Fellowship

https://www.jacc.org/doi/full/10.1016/j.jacep.2022.04.001

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https://www.medscape.com/author/bob-harrington

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Apr 29, 2022 This Week in Cardiology Podcast Apr 29, 2022

Aspirin for primary prevention, time-restricted feeding, renal denervation, and a potential new obesity drug are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – ASA for Primary Prevention:

- USPSTF Final Recommendation on Aspirin for Primary CV Prevention https://www.medscape.com/viewarticle/972761

- Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement https://jamanetwork.com/journals/jama/fullarticle/2791399

- Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/10.1056/NEJMoa1805819

- Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1803955

II – Time Restricted Feeding

- Is There a Benefit to Fasting Plus Calorie Counting? https://www.medscape.com/viewarticle/972579

- Calorie Restriction with or without Time-Restricted Eating in Weight Loss https://www.nejm.org/doi/full/10.1056/NEJMoa2114833

- Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity. The TREAT Randomized Clinical Trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771095

III – Renal Denervation

- Renal Denervation BP Benefits Remain at 3 Years: SPYRAL HTN-ON https://www.medscape.com/viewarticle/971883

- Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial https://doi.org/10.1016/S0140-6736(22)00455-X

IV – Tirzepatide for Obesity

- Tirzepatide Excites in Obesity Now Too, Says Lilly https://www.medscape.com/viewarticle/972936

- Lilly's tirzepatide delivered up to 22.5% weight loss in adults with obesity or overweight in SURMOUNT-1 https://www.prnewswire.com/news-releases/lillys-tirzepatide-delivered-up-to-22-5-weight-loss-in-adults-with-obesity-or-overweight-in-surmount-1--301534871.html

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Apr 22, 2022 This Week in Cardiology Podcast Apr 22, 2022

Critiques of last week’s comments on VT ablation and a review of EHRA presentations, including new ways to ablate atrial myocardium and pace the ventricle, are discussed by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – VT ablation

- VT Ablation After First ICD Shock Boosts Survival: PARTITA https://www.medscape.com/viewarticle/971969

- Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.059598

- Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia https://www.jacc.org/doi/10.1016/j.jacc.2022.01.050

- Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs https://www.nejm.org/doi/full/10.1056/NEJMoa1513614

II – Pulsed-Field Ablation

- Pulsed Field Ablation Treats AF With Few Complications https://www.medscape.com/viewarticle/972147

- Pulsed Field Ablation for Persistent Atrial Fibrillation (PersAFOne): Hope or Hype? https://www.jacc.org/doi/10.1016/j.jacc.2020.07.032

III – High-Power Short Duration Ablation

- Short, High-Power Ablation on Par With Standard AF Ablation https://www.medscape.com/viewarticle/972087

IV – LBB-Area Pacing

- MELOS: LBB Area Pacing Promising for Bradyarrhythmias, HF https://www.medscape.com/viewarticle/972270

Also of interest...

- Conduction System Pacing Noninferior to Biventricular Pacing for HF With Wide QRS https://www.medscape.com/viewarticle/971740

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Questions or feedback, please contact news@medscape.net

Apr 15, 2022 This Week in Cardiology Apr 15, 2022

ACC Recap, Part 2: VT ablation, HF care, three-vessel disease, and patiromer are the topics John Mandrola, MD, covers in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I – VT ablation

VT Ablation After First ICD Shock Boosts Survival: PARTITA

https://www.medscape.com/viewarticle/971969

• Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.059598

• Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia https://www.jacc.org/doi/10.1016/j.jacc.2022.01.050

• Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs https://www.nejm.org/doi/full/10.1056/NEJMoa1513614

II – HF Care

Alerts Improve Prescribing of HF Quadruple Therapy: PROMPT-HF https://www.medscape.com/viewarticle/972079

• Electronic Alerts to Improve Heart Failure Therapy in Outpatient Practice: A Cluster Randomized Trial https://www.jacc.org/doi/10.1016/j.jacc.2022.03.338

• Reassessing Quality Assessment — The Flawed System for Fixing a Flawed System https://www.nejm.org/doi/full/10.1056/NEJMms2200976

III – Three-Vessel Disease

FAME 3 Subanalysis Adds Twist to Negative Primary Results

https://www.medscape.com/viewarticle/971495

• Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery https://www.nejm.org/doi/10.1056/NEJMoa2112299

• Quality of Life After Fractional Flow Reserve-Guided PCI Compared with Coronary Bypass Surgery https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.060049

IV – Treating Drug Side Effects with More Drugs

DIAMOND: Adding Patiromer Helps Optimize HF Meds, Foils Hyperkalemia https://www.medscape.com/viewarticle/971616

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https://www.medscape.com/author/bob-harrington

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news@medscape.net

Apr 8, 2022 This Week in Cardiology Podcast Apr 08, 2022

ACC Recap: John Mandrola, MD, provides part 1 of an ACC recap in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – HTN in Pregnancy

- Hypertension Control During Pregnancy Validated in Large Trial https://www.medscape.com/viewarticle/971486

- Treatment for Mild Chronic Hypertension during Pregnancy https://www.nejm.org/doi/full/10.1056/NEJMoa2201295

II – Prevention of Bleeding in Non-Cardiac Surgery

- POISE-3 Backs Wider Use of Tranexamic Acid in Noncardiac Surgery https://www.medscape.com/viewarticle/971483

- Tranexamic Acid in Patients Undergoing Noncardiac Surgery https://www.nejm.org/doi/full/10.1056/NEJMoa2201171

III – HCM

- VALOR-HCM: Novel Drug May Delay, Avert Invasive Therapy in OHCM https://www.medscape.com/viewarticle/971484

IV – Left Atrial Appendage Occlusion

- Small Leaks After LAAO Linked to Thromboembolism, Bleeding https://www.medscape.com/viewarticle/971709

V – Low Sodium Diet for HF

- Low-Sodium Diet Did Not Cut Clinical Events in Heart Failure Trial https://www.medscape.com/viewarticle/971482

- Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial https://doi.org/10.1016/S0140-6736(22)00369-5

VI – Flu Vaccine and Heart Failure

- Flu Vaccines Cut Seasonal Death in Patients With Heart Failure https://www.medscape.com/viewarticle/971619

VII – New Anticoagulant?

- Less Bleeding With Factor XI Inhibitor Anticoagulant? PACIFIC-AF https://www.medscape.com/viewarticle/971702

Features:

- Sodium Restriction in Heart Failure: Another Dogma Felled by Randomization https://www.medscape.com/viewarticle/971697

- Percutaneous Left Atrial Appendage Occlusion: ACC Data Challenge Promise vs Reality https://www.medscape.com/viewarticle/971512

- Mavacamten in Hypertrophic Cardiomyopathy: Reasons for Both Optimism and Caution https://www.medscape.com/viewarticle/971485

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Questions or feedback, please contact: news@medscape.net

Apr 1, 2022 This Week in Cardiology Podcast Apr 01, 2022

Coronary CTA, semaglutide, coronary artery calcium, exercise, and an ACC and EHRA preview are the topics discussed by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Coronary CTA Feedback

- Coronary Computed Tomography Angiography vs Functional Stress Testing for Patients With Suspected Coronary Artery Disease https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243

II – Semaglutide

- FDA Okays Semaglutide Higher Dose, 2 mg/Week, for Type 2 Diabetes https://www.medscape.com/viewarticle/971156

- Efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial https://doi.org/10.1016/S2213-8587(21)00174-1

- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa1607141

- Once-Weekly Semaglutide in Adults with Overweight or Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

III – CAC and SCD

- Calcium Scores Predict Sudden-Death Risk in Preclinical CAD in Large Cohort Study https://www.medscape.com/viewarticle/971056

- Coronary Artery Calcium for Risk Stratification of Sudden Cardiac Death: The Coronary Artery Calcium Consortium https://www.jacc.org/doi/10.1016/j.jcmg.2022.02.011

IV – Exercise and COVID-19

- More Exercise Linked to Lower Chance of Severe COVID-19: Study https://www.medscape.com/viewarticle/949468

- Small steps, strong shield: directly measured, moderate physical activity in 65 361 adults is associated with significant protective effects from severe COVID-19 outcomes http://dx.doi.org/10.1136/bjsports-2021-105159

V – ACC Preview

- Hybrid ACC.22 Resurrects the Live Scientific Session https://www.medscape.com/viewarticle/971083

- Mandrola Previews the 2022 American College of Cardiology Scientific Sessions https://www.medscape.com/viewarticle/971084

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Questions or feedback, please contact news@medscape.net

Mar 25, 2022 This Week in Cardiology Mar 25, 2022

AF ablation vs rate control in HF, TAVI vs SAVR, atherosclerosis, and surrogate endpoints in observational studies are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I – AF ablation vs Rate Control

RAFT-AF, Despite Itself, Hints at Advantage for Ablation Rhythm Control in Heart Failure With AF https://www.medscape.com/viewarticle/951326

• Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients with Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial https://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.121.057095

• Catheter Ablation for Atrial Fibrillation with Heart Failure

https://www.nejm.org/doi/full/10.1056/nejmoa1707855

• Lenient versus Strict Rate Control in Patients with Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/nejmoa1001337

II – TAVI vs SAVR

Surgery Groups Push Back on VARC-3 Valve Trial Definitions https://www.medscape.com/viewarticle/970753

• Joint Surgical Associations (EACTS, LACES, ASCVTS, AATS, and STS) Position Statement Regarding the VARC-3 Definitions for Aortic Valve Clinical Research https://doi.org/10.1093/ejcts/ezac110

III – Atherosclerosis

Medical Management Best for Atherosclerotic Stroke: New AAN Guidance

https://www.medscape.com/viewarticle/970886

• Stroke Prevention in Symptomatic Large Artery Intracranial Atherosclerosis Practice Advisory https://n.neurology.org/content/98/12/486

IV – ECHO parameters with Rhythm Control

Global Gains in Heart Function From Early AF Rhythm Control

https://www.medscape.com/viewarticle/970329

• Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation https://doi.org/10.1016/j.jacc.2021.12.029

• Effects of Atrial Fibrillation and Sinus Rhythm on Cardiac Remodeling and Valvular Regurgitation https://doi.org/10.1016/j.jacc.2021.12.028

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Mar 11, 2022 This Week in Cardiology Podcast Mar 11, 2022

AF screening, CTA, stroke prevention and broken observational studies, and medical writing are the topics John Mandrola, MD discusses in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - AF Screening

- Handheld ECGs Ease A-Fib Screening in the Very Elderly https://www.medscape.com/viewarticle/969846

- Screening for Atrial Fibrillation in Older Adults at Primary Care Visits: the VITAL-AF Randomized Controlled Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057014

II - CTA

- DISCHARGE: CTA Shows Safety Edge vs Cath in Intermediate-Risk Stable Chest Pain https://www.medscape.com/viewarticle/969732

- CT or Invasive Coronary Angiography in Stable Chest Pain https://www.nejm.org/doi/full/10.1056/NEJMoa2200963

III - Stroke Prevention post TAVI

- Silver Lining Emerges for Embolic Protection in Post-TAVR Stroke https://www.medscape.com/viewarticle/969992

- Cerebral Embolic Protection and Stroke-Related Mortality Following Transcatheter Aortic Valve Replacement https://www.jacc.org/doi/full/10.1016/j.jcin.2022.01.007

- Safety and efficacy of cerebral protection devices in transcatheter aortic valve replacement: A clinical end-points meta-analysis https://pubmed.ncbi.nlm.nih.gov/29550047/

- Cerebral Embolic Protection and Outcomes of Transcatheter Aortic Valve Replacement: Results From the Transcatheter Valve Therapy Registry https://pubmed.ncbi.nlm.nih.gov/33619968/

IV - Medical Writing

- Writing Program Asks Physicians to Explore Their Experiences https://www.medscape.com/viewarticle/969973

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Questions or feedback, please contact news@medscape.net

Mar 4, 2022 This Week in Cardiology Mar 04, 2022

An update to CardioMEMs post, ARBs and cancer, troponins, empagliflozin, and low-value care are the topics discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Invasive Monitoring for HF

- FDA Expands Eligibility for CardioMEMS Heart Failure System https://www.medscape.com/viewarticle/969004

- Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01754-2

II – ARBs and Cancer

- ARBs and Cancer Risk: New Meta-Analysis Raises Questions Again https://www.medscape.com/viewarticle/969510

- Risk of cancer with angiotensin-receptor blockers increases with increasing cumulative exposure: Meta-regression analysis of randomized trials https://doi.org/10.1371/journal.pone.0263461

- Marciniak Meta-analysis in FDA Medical Review 206316Orig1Orig2s000 https://rb.gy/myhlvy

III – Troponins and Cardiac Surgery

- What Troponin Level Indicates Injury After Cardiac Surgery? https://www.medscape.com/viewarticle/969617?src=

- High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality https://www.nejm.org/doi/full/10.1056/NEJMoa2000803

- Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease https://www.nejm.org/doi/full/10.1056/nejmoa1909406

IV – Empagliflozin in HFpEF

- FDA Okays Empagliflozin for HF Regardless of Ejection Fraction https://www.medscape.com/viewarticle/969118

- Empagliflozin in Heart Failure with a Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

- Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa1908655

V – Low-Value Care

- AHA Targets 'Low-Value' Heart Care in New Scientific Statement https://www.medscape.com/viewarticle/969107

- Strategies to Reduce Low-Value Cardiovascular Care: A Scientific Statement From the American Heart Association https://www.ahajournals.org/doi/abs/10.1161/HCQ.0000000000000105

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Questions or feedback, please contact news@medscape.net

Feb 25, 2022 This Week in Cardiology Podcast Feb 25, 2022

FDA approval of CardioMEMS, statins, VT storm, and fish oil and AF are the topics covered by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - Invasive Monitoring for HF

- FDA Expands Eligibility for CardioMEMS Heart Failure System https://www.medscape.com/viewarticle/969004

- Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01754-2

- Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial https://doi.org/10.1016/S0140-6736(11)60101-3

II - Statin Use in Primary Prevention

- USPSTF Tweaks Primary Prevention Statin Recommendations in New Draft Guidance https://www.medscape.com/viewarticle/968963

- Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication https://www.uspreventiveservicestaskforce.org/uspstf/document/draft-evidence-review/statin-use-primary-prevention-cardiovascular-disease-adults

- The Case Against Coronary Artery Calcium Scoring for Cardiovascular Disease Risk Assessment https://www.aafp.org/afp/2019/1215/p734.html

III - VT-Storm

- Transcutaneous Magnetic Stimulation Promising Against VT Storm https://www.medscape.com/viewarticle/968955

- Effect of Transcutaneous Magnetic Stimulation in Patients With Ventricular Tachycardia Storm https://jamanetwork.com/journals/jamacardiology/fullarticle/2788915

IV - Fish Oil and AF risk

- Fish Oil Supplements May Increase the Risk for Atrial Fibrillation: What Does This Mean? https://www.medscape.com/viewarticle/967159

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Questions or feedback, please contact news@medscape.net

Feb 18, 2022 This Week in Cardiology Podcast Feb 18, 2022

Spinal cord stimulation to prevent post-cardiac surgery AF, statin intolerance, heart failure with preserved ejection fraction, and Vitamin D are discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com//twic

I Post-Cardiac Surgery AF

Spinal Cord Stimulation May Cut AF After Cardiac Surgery

https://www.medscape.com/viewarticle/968478

• Autonomic Neuromodulation for Atrial Fibrillation Following Cardiac Surgery: JACC Review Topic of the Week https://www.jacc.org/doi/10.1016/j.jacc.2021.12.010

• Temporary Spinal Cord Stimulation to Prevent Postcardiac Surgery Atrial Fibrillation: 30-Day Safety and Efficacy Outcomes https://www.jacc.org/doi/10.1016/j.jacc.2021.08.078

II – Statin Intolerance

Statin Intolerance 'Overestimated and Overdiagnosed' https://www.medscape.com/viewarticle/968627

• Prevalence of statin intolerance: a meta-analysis https://doi.org/10.1093/eurheartj/ehac015

III – HFpEF

Risk in Preserved-EF HF Varies With Normal vs High Natriuretic Peptides https://www.medscape.com/viewarticle/968748

• Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality https://doi.org/10.1093/eurheartj/ehab911

• Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association https://pubmed.ncbi.nlm.nih.gov/33605000/

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Why Is Vitamin D Hype So Impervious to Evidence? https://www.medscape.com/viewarticle/968682

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https://www.medscape.com/author/bob-harrington

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Feb 11, 2022 This Week in Cardiology Podcast Feb 11, 2022

LDL equations, stroke interventions, post-PCI antiplatelets, the transitive function and network meta-analysis, and lipoprotein(a) are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - LDL-C Equations:

- Standard LDL Equations Yield Discordant Results https://www.medscape.com/viewarticle/968112

- Discordance Between Standard Equations for Determination of LDL Cholesterol in Patients With Atherosclerosis https://www.jacc.org/doi/10.1016/j.jacc.2021.11.042

- LDL-C Estimation: The Perils of Living With Imperfection https://www.jacc.org/doi/10.1016/j.jacc.2021.12.005

II - Acute Stroke Care

- Endovascular Therapy Benefits Stroke With Larger Ischemic Core? https://www.medscape.com/viewarticle/968203

- Endovascular Therapy for Acute Stroke with a Large Ischemic Region https://www.nejm.org/doi/full/10.1056/NEJMoa2118191

III - Post PCI Antiplatelet Regimens

- Study Parses Out Merits of Short DAPT, De-escalation in ACS https://www.medscape.com/viewarticle/968050

- Short Duration of DAPT Versus De-Escalation After Percutaneous Coronary Intervention for Acute Coronary Syndromes https://www.jacc.org/doi/10.1016/j.jcin.2021.11.028

IV - Lipoprotein (a)

- Positive Topline Results for siRNA in Raised Lipoprotein(a) https://www.medscape.com/viewarticle/968278

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Questions or feedback, please contact news@medscape.net

Feb 4, 2022 This Week in Cardiology Podcast Feb 04, 2022

Interatrial shunt therapy, the power of the RCT, chronic stress, anxiety and cardiometabolic risk, and TAVR, are the topics covered by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - Interatrial Shunt

- Interatrial Shunt Falters in Preserved, Mid-Range LVEF Heart Failure: REDUCE LAP-HF 2 https://www.medscape.com/viewarticle/967792

- Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial https://doi.org/10.1016/S0140-6736(22)00016-2

II - Chronic Stress

- Chronic Stress Accelerates Aging: Epigenetic Evidence https://www.medscape.com/viewarticle/967828

- Psychological and biological resilience modulates the effects of stress on epigenetic aging https://www.nature.com/articles/s41398-021-01735-7

- DNA methylation GrimAge strongly predicts lifespan and healthspan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366976/

III – Anxiety, Neuroticism, and CardioMetabolic Risk Factors

- Anxiety in Men Tied to Risk Factors for CVD, Diabetes https://www.medscape.com/viewarticle/967811

- Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40‐Year Study of Men https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022006

IV - TAVR Implant Success

- VARC-3 TAVR Technical Failure Definition 'Highly Clinically Relevant https://www.medscape.com/viewarticle/967717

- Validation of the Valve Academic Research Consortium 3 Technical Success Definition in Patients Undergoing TAVR https://www.jacc.org/doi/full/10.1016/j.jcin.2021.11.013

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Questions or feedback, please contact news@medscape.net

Jan 28, 2022 This Week in Cardiology Podcast Jan 28, 2022

AF Screening, alcohol, sports-related sudden death, non-MD-led healthcare, and CPR are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - AF Screening

- USPSTF Says Evidence Still Lacking for AF Screening in Asymptomatic Patients https://www.medscape.com/viewarticle/967275

- Screening for Atrial Fibrillation US Preventive Services Task Force Recommendation Statement https://jamanetwork.com/journals/jama/fullarticle/2788340

- Screening for Atrial Fibrillation—New Devices, Same Challenges https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788475

- Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01698-6

II - Vaccine Induced Myocarditis

- Hong Kong, US, Israeli Data Illuminate COVID Vaccine Myocarditis https://www.medscape.com/viewarticle/967355

III - Alcohol and Heart

- No Amount of Alcohol Safe for the Heart: WHF https://www.medscape.com/viewarticle/967124

IV - Sports Related Sudden Cardiac Arrest

- Survival Improving in Sports-Related Sudden Cardiac Arrest https://www.medscape.com/viewarticle/967061

- Evolution of Incidence, Management, and Outcomes Over Time in Sports-Related Sudden Cardiac Arrest https://www.jacc.org/doi/full/10.1016/j.jacc.2021.11.011

V - Non MD vs MD-led Care

- This Doc Still Supports NP/PA Led Care ... With Caveats https://www.medscape.com/viewarticle/967073

VI - CPR

- Should We Always Offer CPR? https://www.medscape.com/viewarticle/966886

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Jan 21, 2022 This Week in Cardiology Podcast Jan 21, 2022

Olive oil, breastfeeding and CV health, informed consent during stroke, and controversy regarding revascularization guidelines are the topics John Mandrola, MD, covers in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Olive Oil

- Olive Oil Intake Tied to Reduced Mortality https://www.medscape.com/viewarticle/966366

- Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults https://www.jacc.org/doi/full/10.1016/j.jacc.2021.10.041

- Can Small Amounts of Olive Oil Keep the Death Away? https://www.jacc.org/doi/10.1016/j.jacc.2021.11.006

II – Breastfeeding and CV Maternal Health

- Breastfeeding Linked to Lower CVD Risk in Later Life https://www.medscape.com/viewarticle/966767

- Breastfeeding Is Associated With a Reduced Maternal Cardiovascular Risk: Systematic Review and Meta‐Analysis Involving Data From 8 Studies and 1 192 700 Parous Women https://www.ahajournals.org/doi/10.1161/JAHA.121.022746

- Meta-analysis: pitfalls and hints https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868184/

III – Informed Consent

- New Guidance on Consent in Acute Ischemic Stroke https://www.medscape.com/viewarticle/966889

- Consent Issues in the Management of Acute Ischemic Stroke https://n.neurology.org/content/98/2/73

- The Case Against Thrombolytic Therapy in Stroke https://www.medscape.com/viewarticle/895159

- tPA in Stroke: 'The Facts Are Clear' https://www.medscape.com/viewarticle/895370

IV – Controversy in Revascularization Guidelines

- 'Incomprehensible' CABG Recommendation Raises Concerns https://www.medscape.com/viewarticle/966819

- Surgical Groups Push Back Against New Revascularization Guidelines https://www.medscape.com/viewarticle/966153

- Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration https://doi.org/10.1016/S0140-6736(94)91963-1

- Ten-Year Follow-Up Survival of the Medicine, Angioplasty, or Surgery Study (MASS II) https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.911669

- What constitutes an appropriate empirical trial of antianginal therapy in patients with stable angina before referral for revascularisation? https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02045-6/fulltext

- Initial Invasive or Conservative Strategy for Stable Coronary Disease https://www.nejm.org/doi/full/10.1056/nejmoa1915922

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Jan 14, 2022 This Week in Cardiology Podcast Jan 14, 2022

Xeno-transplantation, weight loss drugs, DOAC coverage, vitamin D, LAAC and frailty, and recalled LVADs are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Xenotransplantation

- Pig Heart Successfully Transplanted to Man https://www.medscape.com/viewarticle/966367

- What Does a Pig-to-Human Heart Transplant Mean for Medicine? https://www.medscape.com/viewarticle/966488

II – Weight Loss Drugs

- Wegovy Tops Sibling Saxenda for Weight Loss https://www.medscape.com/viewarticle/966376

- Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes https://jamanetwork.com/journals/jama/article-abstract/2787907

III – DOAC Coverage

- CVS Caremark Formulary Change Freezes Out Apixaban https://www.medscape.com/viewarticle/966588

IV – Vitamin D

- More Vitamin D Not Better for Reducing Cancer or CVD Incidence https://www.medscape.com/viewarticle/966333

- The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality https://doi.org/10.1016/S2213-8587(21)00345-4

- Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial https://doi.org/10.1093/ajcn/nqab419

- Association between vitamin D supplementation and mortality: systematic review and meta-analysis https://www.bmj.com/content/366/bmj.l4673

V – LAAC and Frailty

- Frailty in patients undergoing percutaneous left atrial appendage closure https://doi.org/10.1016/j.hrthm.2022.01.007

- Net Clinical Benefit of Left Atrial Appendage Closure Versus Warfarin in Patients With Atrial Fibrillation: A Pooled Analysis of the Randomized PROTECT-AF and PREVAIL Studies https://pubmed.ncbi.nlm.nih.gov/31752643/

VI – LVAD recall

- A High-Risk Medical Device Didn't Meet Federal Standards. The Government Paid Millions for More. https://www.medscape.com/viewarticle/966255

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Questions or feedback, please contact news@medscape.net

This podcast is intended for US health professionals only.

Jan 7, 2022 This Week in Cardiology Podcast Jan 07, 2022

Causes of sudden death, inclisiran, DOAC choices, and alcohol and VT/VF are the topics discussed by John Mandrola, MD, in this week’s podcast.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – Causes of Sudden Death

- Cardiac Device Interrogation After Death 'Richly Informative' https://www.medscape.com/viewarticle/965730

- Postmortem Interrogation of Cardiac Implantable Electronic Devices: A 15-Year Experience https://www.jacc.org/doi/full/10.1016/j.jacep.2021.10.011

- Sudden Death in Patients With Cardiac Implantable Electronic Devices https://pubmed.ncbi.nlm.nih.gov/26098676/

- Cardiac Implantable Electronic Device Interrogation at Forensic Autopsy https://www.ahajournals.org/doi/full/10.1161/circulationaha.117.032367

II – Inclisiran

- FDA Approves First-in-Class Inclisiran to Lower LDL-C https://www.medscape.com/viewarticle/965464

- ORION: Inclisiran Phase 3 Trials Published https://www.medscape.com/viewarticle/927107

- Meta-Analysis of Inclisiran for the Treatment of Hypercholesterolemia https://pubmed.ncbi.nlm.nih.gov/32892993/

- Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease https://www.nejm.org/doi/full/10.1056/nejmoa1615664

- Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome https://www.nejm.org/doi/10.1056/NEJMoa1801174

III – DOAC Choice

- Apixaban: The 'Anticoagulant of Choice' for AF https://www.medscape.com/viewarticle/965390

- Association of Rivaroxaban vs Apixaban With Major Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2787319

IV – Alcohol and VT/VF and SCD

- Some Good News on Alcohol and 'Holiday Heart Syndrome' https://www.medscape.com/viewarticle/965498

- Alcohol consumption and risk of ventricular arrhythmias and sudden cardiac death: An observational study of 408,712 individuals https://www.heartrhythmjournal.com/article/S1547-5271(21)02215-3/fulltext

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Questions or feedback, please contact news@medscape.net

Dec 17, 2021 This Week in Cardiology Podcast Dec 17, 2021

PFO closure, trans-mitral procedures, yoga as therapy, and a year-end-review are the topics John Mandrola, MD, covers in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – PFO Closure

- Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke https://jamanetwork.com/journals/jama/fullarticle/2787115

- Patent Foramen Ovale Closure—Harnessing Clinical Trial Evidence to Inform Individualized Treatment Decisions https://jamanetwork.com/journals/jama/fullarticle/2787132

- Personalized evidence based medicine: predictive approaches to heterogeneous treatment effects https://pubmed.ncbi.nlm.nih.gov/30530757/

- Lord’s Paradox by Stephen Senn https://www.linkedin.com/pulse/cause-concern-stephen-senn/

II – Trans-Mitral Procedures

- Transcatheter Mitral Valve Procedures Up Tenfold Since 2014 https://www.medscape.com/viewarticle/964657

- Transcatheter Mitral Valve Therapy in the United States: A Report From the STS-ACC TVT Registry https://www.jacc.org/doi/full/10.1016/j.jacc.2021.07.058

- Percutaneous Repair or Surgery for Mitral Regurgitation https://www.nejm.org/doi/full/10.1056/nejmoa1009355

- Transcatheter Mitral-Valve Repair in Patients with Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1806640

- Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation https://www.nejm.org/doi/full/10.1056/NEJMoa1805374

III – Yoga for Vasovagal Syncope

- Yoga Effective Adjunct Therapy in Recurrent Vasovagal Syncope https://www.medscape.com/viewarticle/964644

- Effect of Yoga on Clinical Outcomes and Quality of Life in Patients With Vasovagal Syncope (LIVE-Yoga) https://www.jacc.org/doi/full/10.1016/j.jacep.2021.09.007

- Effect of Yoga on Arrhythmia Burden, Anxiety, Depression, and Quality of Life in Paroxysmal Atrial Fibrillation: The YOGA My Heart Study https://www.jacc.org/doi/full/10.1016/j.jacc.2012.11.060

- Effects of yoga in patients with paroxysmal atrial fibrillation - a randomized controlled study https://pubmed.ncbi.nlm.nih.gov/26976659/

IV – Top Ten of 2021

- Mandrola's Top 10 Cardiology Stories of 2021 https://www.medscape.com/viewarticle/964818

- Top Cardiology Trials of 2021 https://www.medscape.com/viewarticle/963475

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Questions or feedback, please contact news@medscape.net

Dec 10, 2021 This Week in Cardiology Podcast Dec 10, 2021

AF triggers, rising BP during the pandemic, long COVID, cardiac arrest care, and social media are the topics John Mandrola, MD discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – AF Triggers

- Alcoholic Drinks Stand Out in Novel Trial Exploring AF Triggers https://www.medscape.com/viewarticle/962911

- Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation https://jamanetwork.com/journals/jamacardiology/article-abstract/2786196

II – BP Increase During the Pandemic

- Blood Pressure Control Worsened During COVID Pandemic https://www.medscape.com/viewarticle/964329

- Rise in Blood Pressure Observed Among US Adults During the COVID-19 Pandemic https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057075

III – DOAC after VTE

- Apixaban Outmatches Rivaroxaban for VTE in Study https://www.medscape.com/viewarticle/964301

- Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban: An Analysis of Real-World Data https://www.acpjournals.org/doi/full/10.7326/M21-0717

- Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa1908973

IV – Long Covid

- In Long COVID, CPET Finds Abnormalities Other Tests Don't https://www.medscape.com/viewarticle/964250

- Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post–Coronavirus Disease https://doi.org/10.1016/j.jchf.2021.10.002

V – Cardiac Arrest Care

- Calcium Does Not Benefit Patients in Cardiac Arrest https://www.medscape.com/viewarticle/964059

- Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest https://jamanetwork.com/journals/jama/fullarticle/2786819

VI – Social Media

- Online Reviews Most Important Factor in Choosing a Doctor: Survey https://www.medscape.com/viewarticle/964264

Features:

- Booze Out, Coffee Okay to Outsmart Atrial Fibrillation? https://www.medscape.com/viewarticle/961993

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Dec 3, 2021 This Week in Cardiology Podcast Dec 03, 2021

The AMAZE trial of left atrial appendage isolation, non-statin oral lipid lowering drugs, EHR alerts, non-MD care, and obesity are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I – aMAZE Trial

- No Advantage Shown for LAA Ligation as Adjunct to Pulmonary Vein Isolation https://www.medscape.com/viewarticle/962954

- Safety and Procedural Success of Left Atrial Appendage Exclusion With the Lariat Device https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2289126

- Left Atrial Appendage Isolation in Patients With Longstanding Persistent AF Undergoing Catheter Ablation: BELIEF Trial https://pubmed.ncbi.nl m.nih.gov/27788847/

II – Non-Statin Lipid Lowering

- Obicetrapib: CETP Inhibitor Impresses in LDL Lowering https://www.medscape.com/viewarticle/963611

- Daily Oral PCSK9 Inhibitor Encouraging in Phase 1 Trials https://www.medscape.com/viewarticle/963550

III – EHR Alerts and Prognosis

- EHR Alerts Have No Impact on Inpatient HF Treatment or Outcomes https://www.medscape.com/viewarticle/963002

- REVeAL-HF: Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice https://www.jacc.org/doi/full/10.1016/j.jchf.2021.03.006

IV – Non-MD Care Models

- Remote Non-Physician Care Helps BP, LDL Control https://www.medscape.com/viewarticle/963783

- A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153

V – Obesity in the Young

- Obesity Rates Soar in Early Adulthood in the US https://www.medscape.com/viewarticle/963511

- Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018 https://jamanetwork.com/journals/jama/article-abstract/2786516

Features

- Doubting the BELIEF Trial on LAA Isolation https://www.medscape.com/viewarticle/850822

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Nov 19, 2021 This Week in Cardiology Podcast Nov 19, 2021

In AHA 2021 Part 1, John Mandrola, MD, reports on selected sessions from the virtual American Heart Association meeting.

To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - AVATAR

- Early SAVR Tops Watchful Waiting in Severe, Asymptomatic Aortic Stenosis: AVATAR https://www.medscape.com/viewarticle/962904

- Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis: The AVATAR Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639

- Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis https://www.nejm.org/doi/full/10.1056/NEJMoa1912846

II - TCV Repair

- Concomitant Tricuspid-Mitral Surgery Beneficial but With a Tradeoff https://www.medscape.com/viewarticle/962899

- Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation https://www.nejm.org/doi/full/10.1056/NEJMoa2115961

III - PALACS

- Procedure Reduces Postop AF After Cardiac Surgery: PALACS https://www.medscape.com/viewarticle/962907

- Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: an adaptive, single-centre, single-blind, randomised, controlled trial https://doi.org/10.1016/S0140-6736(21)02490-9

IV - Left Main CAD

- Left-Main PCI, CABG Mortality Similar; Choice Remains Complex https://www.medscape.com/viewarticle/963198

- Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis https://doi.org/10.1016/S0140-6736(21)02334-5

Features:

- Questions Remain on Tricuspid Repair at Time of Mitral Surgery https://www.medscape.com/viewarticle/962902

- Despite Positive Trials, Early Surgery in Asymptomatic AS Should Wait https://www.medscape.com/viewarticle/962926

- Can New Meta-analysis of PCI vs CABG for Left Main CAD Settle the Debate? https://www.medscape.com/viewarticle/963295

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Nov 12, 2021 This Week in Cardiology Podcast Nov 12, 2021

Left atrial appendage closure vs DOACs, TAVR vs SAVR, renal denervation, and an AHA 2021 preview are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - LAAC

- PRAGUE-17: LAA Closure Holds Up Against DOACs Out to 4 Years https://www.medscape.com/viewarticle/962608

- LAAO vs DOAC: PRAGUE-17 Falls Short https://www.medscape.com/viewarticle/933641

- Left Atrial Appendage Closure versus Non-Warfarin Oral Anticoagulation in Atrial Fibrillation: 4-Year Outcomes of PRAGUE-17 https://www.jacc.org/doi/10.1016/j.jacc.2021.10.023

- Does Percutaneous Left Atrial Appendage Closure Stand the Test of Time? https://www.jacc.org/doi/10.1016/j.jacc.2021.10.022

II - SURTAVI (TAVR vs SAVR)

- SURTAVI at 5 Years Reinforces TAVR but Was It Long-term Enough? https://www.medscape.com/viewarticle/962484

- Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients https://www.nejm.org/doi/full/10.1056/NEJMoa1700456

III - Renal Denervation

- Renal Denervation Adds Clout to BP Meds in Resistant HTN: RADIANCE-HTN TRIO https://www.medscape.com/viewarticle/962508

- Renal Denervation Remains Only Promising in Meta-Analysis https://www.medscape.com/viewarticle/962369

- Renal Denervation for Hypertension: A Systematic Review and Meta-Analysis of Randomized, Blinded, Placebo-Controlled Trials https://doi.org/10.1016/j.jcin.2021.09.020

IV - AHA Preview

- AHA 2021 Puts Scientific Dialogue, Health Equity Center Stage https://www.medscape.com/viewarticle/962524

- Mandrola Previews the Virtual AHA 2021 https://www.medscape.com/viewarticle/962468

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Nov 5, 2021 This Week in Cardiology Podcast Nov 05, 2021

FFR-guided PCI, ISCHEMIA trial challenged, QFR, and one of the most important studies of 2021 are discussed by John Mandrola, MD, in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - FFR-Guided PCI

- FFR-Guided PCI Falls Short vs CABG in Multivessel CAD: FAME 3 https://www.medscape.com/viewarticle/962274

- Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery https://www.nejm.org/doi/full/10.1056/NEJMoa2112299

- The fallacies of fractional flow reserve https://pubmed.ncbi.nlm.nih.gov/31889563/

II - ISCHEMIA-Trial Challenged

- How Applicable is ISCHEMIA Trial to US Clinical Practice? https://www.medscape.com/viewarticle/962233

- Comparison of Patients Undergoing Percutaneous Coronary Intervention in Contemporary U.S. Practice With ISCHEMIA Trial Population https://www.jacc.org/doi/full/10.1016/j.jcin.2021.08.047

- The Glass Is at Least Half Full https://www.jacc.org/doi/10.1016/j.jcin.2021.08.054

- Initial Invasive or Conservative Strategy for Stable Coronary Disease https://www.nejm.org/doi/full/10.1056/nejmoa1915922

III - QFR

- FAVOR III China: QFR-Guided PCI Shows Advantage Over Angiography https://www.medscape.com/viewarticle/962328

- Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial https://doi.org/10.1016/S0140-6736(21)02248-0

Features:

- The MI–Mortality Mismatch: When Lowering MI Doesn't Extend Life https://www.medscape.com/viewarticle/962276

- Assessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2785560

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Oct 29, 2021 This Week in Cardiology Oct 29, 2021

ESUS, CAC 0, Takotsubo syndrome, and chest pain are the topics John Mandrola, MD, covers in today’s podcast. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I – ESUS

Anticoagulation May Benefit Stroke Patients With LV Dysfunction https://www.medscape.com/viewarticle/961815

- Left Ventricular Dysfunction Among Patients With Embolic Stroke of Undetermined Source and the Effect of Rivaroxaban vs AspirinA Subgroup Analysis of the NAVIGATE ESUS Randomized Clinical Trial

https://jamanetwork.com/journals/jamaneurology/article-abstract/2785030

- Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source

https://www.nejm.org/doi/10.1056/NEJMoa1802686

- Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source

https://www.nejm.org/doi/10.1056/NEJMoa1813959

II – CAC

CAC Score 0 Unreliable to Rule Out Stenosis in Younger Patients https://www.medscape.com/viewarticle/961801

- Association of Age With the Diagnostic Value of Coronary Artery Calcium Score for Ruling Out Coronary Stenosis in Symptomatic Patients https://jamanetwork.com/journals/jamacardiology/fullarticle/2785586

- The Case Against Coronary Artery Calcium Scoring for Cardiovascular Disease Risk Assessment

https://www.aafp.org/afp/2019/1215/p734.html

III – Takotsubo Cardiomyopathy

Broken Heart Syndrome: On the Rise, Especially in Women 50-74

https://www.medscape.com/viewarticle/961307

- Sex‐ and Age‐Based Temporal Trends in Takotsubo Syndrome Incidence in the United States

https://www.ahajournals.org/doi/10.1161/JAHA.120.019583

IV- Chest Pain Guidelines

AHA/ACC Issues First Comprehensive Guidance on Chest Pain

https://www.medscape.com/viewarticle/961806

- 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.jacc.org/doi/10.1016/j.jacc.2021.07.052

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Oct 22, 2021 This Week in Cardiology Podcast Oct 22, 2021

Aspirin for primary prevention, induced hypothermia, half-dose DOAC, and social media, are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - ASA for Primary Prevention

- USPSTF Rules Out Aspirin for Over 60s in Primary CVD Prevention https://www.medscape.com/viewarticle/960745

- Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication https://www.uspreventiveservicestaskforce.org/uspstf/document/draft-evidence-review/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication

- Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31924-X/fulltext

- Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus https://www.nejm.org/doi/full/10.1056/nejmoa1804988

- Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1805819

- Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/nejmoa1803955

II - Induced Hypothermia

- No Benefit From Lower Temps for Out-of-Hospital Cardiac Arrest https://www.medscape.com/viewarticle/961191

- The CAPITAL CHILL Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2785263

- Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa1310519

- Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest https://www.nejm.org/doi/full/10.1056/NEJMoa2100591

III - Half-dose DOAC

- Half-Dose DOACs Cut Bleeding, Thrombus Risk Post-Watchman LAA Closure https://www.medscape.com/viewarticle/960974

- Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion https://www.jacc.org/doi/full/10.1016/j.jcin.2021.07.031

IV - Social Media

- Navigating Benefits, Pitfalls of Social Media as a Female Doctor https://www.medscape.com/viewarticle/961150

- Gender Differences in Physician Use of Social Media for Professional Advancement https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779868

Features:

- USPSTF Statement on Aspirin: Poor Messaging at Best https://www.medscape.com/viewarticle/961118

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Oct 8, 2021 This Week in Cardiology Podcast Oct 08, 2021

Two NEJM papers on mRNA-related myocarditis, AF and stroke, intensifying BP meds, and CCTA and high-sensitivity troponin are the topics John Mandrola, MD, covers in this week's podcast. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I -- Vaccine-Induced Myocarditis

New Reports Help Nail Down Myocarditis Risk With COVID-19 Vaccine

https://www.staging.medscape.com/viewarticle/960537

• Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel

https://www.nejm.org/doi/full/10.1056/NEJMoa2109730

• Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

https://www.nejm.org/doi/full/10.1056/NEJMoa2110737

II – AF and Stroke

AF a Stroke Cause or Innocent Bystander? The Debate Continues

https://www.medscape.com/viewarticle/960224

• Temporal Association Between Episodes of Atrial Fibrillation and Risk of Ischemic Stroke

https://jamanetwork.com/journals/jamacardiology/fullarticle/2784332

• It's Time to Rethink (and Retrial) Our Framework for Stroke Prevention in Atrial Fibrillation

https://jamanetwork.com/journals/jamacardiology/fullarticle/2784335

III- Intensification of BP Control

Adding New Hypertensive May Be More Potent Than Upping Doses

https://www.medscape.com/viewarticle/960454

• Adding a New Medication Versus Maximizing Dose to Intensify Hypertension Treatment in Older Adults

https://doi.org/10.7326/M21-1456

IV- Hs-troponin and CAD

Troponin Levels Tied to Increased CAD Risk, May Guide Imaging /viewarticle/960146

• Troponin-Guided Coronary Computed Tomographic Angiography After Exclusion of Myocardial Infarction

https://doi.org/10.1016/j.jacc.2021.07.055

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Oct 1, 2021 This Week in Cardiology Podcast Oct 01, 2021

Coronary artery calcification and exercise, translating clinical trials, the question of metabolically healthy obesity, and Watchman complications are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - CAC and Physical Activity

- Physical Activity Paradoxically Tied to Higher Coronary Calcium https://www.medscape.com/viewarticle/959366

- Physical activity and the progression of coronary artery calcification http://dx.doi.org/10.1136/heartjnl-2021-319346

II - Translating Clinical Trials

- SYNTAX Score II 2020 Wobbles in Real-World Validation https://www.medscape.com/viewarticle/958834

- Redevelopment and validation of the SYNTAX score II to individualise decision making between percutaneous and surgical revascularisation in patients with complex coronary artery disease: secondary analysis of the multicentre randomised controlled SYNTAXES trial with external cohort validation https://doi.org/10.1016/S0140-6736(20)32114-0

- External Validation of the SYNTAX Score II 2020 https://www.jacc.org/doi/full/10.1016/j.jacc.2021.07.027

III - Healthy and Obesity

- ‘Metabolically Healthy Obesity’ Has Heart Risks. Is it a Misnomer? https://www.medscape.com/viewarticle/959994

- Metabolically healthy obesity and cardiovascular events: A nationwide cohort study https://doi.org/10.1111/dom.14492

- Relation of Obesity to New-Onset Atrial Fibrillation and Atrial Flutter in Adults https://pubmed.ncbi.nlm.nih.gov/29501206/

- Paediatric obesity appears to lower the risk of diabetes if selection bias is ignored https://pubmed.ncbi.nlm.nih.gov/29374028

IV - Watchman Complications

- FDA Investigating Potential Sex Differences in LAAO Adverse Outcomes https://www.medscape.com/viewarticle/959806

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Sep 24, 2021 This Week in Cardiology Podcast Sep 24, 2021

Dual antiplatelet therapy after PCI, statin side effects, nightshift work and AF, and a cautionary note regarding therapeutic enthusiasm in HF care are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - COVID

- Alaska Sets Record for Daily COVID Cases https://www.medscape.com/viewarticle/958999

II - MASTER DAPT

- MASTER DAPT: 1 Month DAPT Enough After High-Bleeding-Risk PCI https://www.medscape.com/viewarticle/957463

- Antiplatelets and Anticoagulation Post-PCI: More on MASTER DAPT https://www.medscape.com/viewarticle/958002

- Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk https://www.nejm.org/doi/full/10.1056/NEJMoa2108749

- Abbreviated Antiplatelet Therapy in Patients at High Bleeding Risk With or Without Oral Anticoagulant Therapy After Coronary Stenting: An Open-Label, Randomized, Controlled Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056680

III - Statins and Side Effects

- Most Muscle Pain on Statins Not a Drug Effect: SAMSON in Print https://www.medscape.com/viewarticle/958877

- Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://doi.org/10.1016/j.jacc.2021.07.022

IV - Nightshift Work and AF

- Regular Nightshift Work Linked to Atrial Fibrillation, CHD https://www.medscape.com/viewarticle/959346?src=

- Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease https://doi.org/10.1093/eurheartj/ehab505

V - Enthusiasm for HF Therapy

- Empagliflozin's HFpEF Efficacy Catalyzes Redefinition of HF https://www.medscape.com/viewarticle/959249

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Sep 17, 2021 This Week in Cardiology Podcast Sep 17, 2021

Cardiac arrest care, finerenone, carotids, meds post TAVI: less is more and the new may not be as grand as the tried and true. John Mandrola, MD, provides a third ESC review. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - Cardiac Arrest Care

- Angiography Can Wait for Cardiac Arrest Without ST-Elevation https://www.medscape.com/viewarticle/957471

- Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation https://www.nejm.org/doi/full/10.1056/NEJMoa2101909

- Coronary Angiography after Cardiac Arrest without ST-Segment Elevation https://www.nejm.org/doi/full/10.1056/NEJMoa1816897

II - Finerenone

- FIDELITY: Finerenone Cuts CV Risk in T2D Across CKD Spectrum https://www.medscape.com/viewarticle/957470

- Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2110956

- Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2025845

III - Carotid Intervention

- ACST-2: Carotid Stenting, Surgery on Par in Asymptomatic Patients https://www.medscape.com/viewarticle/957474

- Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy https://doi.org/10.1016/S0140-6736(21)01910-3

IV - Post TAVI DOAC

- 'Less Is More' for Edoxaban in Post-TAVI Anticoagulation: ENVISAGE-TAVI AF https://www.medscape.com/viewarticle/957466

- Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2111016

- ATLANTIS Hints at How to Choose Post-TAVR Antithrombotics https://www.medscape.com/viewarticle/951234

- A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement https://www.nejm.org/doi/full/10.1056/NEJMoa1911425

Features:

- What Are the Implications of ACST-2 for Patients With Asymptomatic Carotid Stenosis? https://www.medscape.com/viewarticle/957502

- Top 5 Studies From ESC 2021 https://www.medscape.com/viewarticle/958598

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Sep 10, 2021 This Week in Cardiology Podcast Sep 10, 2021

ESC Wrap-up Part II: EMPEROR-Preserved, and the STEP, Guide-HF, and IAMI trials, are discussed by John Mandrola, MD, in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

I - HFpEF

- EMPEROR-Preserved: Empagliflozin Scores HFpEF Breakthrough https://www.medscape.com/viewarticle/957405

- Empagliflozin in Heart Failure with a Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

II - BP Targets

- STEP: Lowering Blood Pressure Below 130 mm Hg Shows CV Benefit https://www.medscape.com/viewarticle/957566

- Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension https://www.nejm.org/doi/full/10.1056/NEJMoa2111437

III- PA Catheter Monitoring

- GUIDE-HF: CardioMEMS-Guided Meds Fall Short in Mild to Moderate Heart Failure https://www.medscape.com/viewarticle/957390

- Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01754-2

- Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial https://doi.org/10.1016/S0140-6736(11)60101-3

IV - Influenza Vaccine

- Seasonal Flu Vax Cuts Post-MI Mortality in IAMI Trial https://www.medscape.com/viewarticle/957575

- Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial https://doi.org/10.1161/CIRCULATIONAHA.121.057042

- Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis https://pubmed.ncbi.nlm.nih.gov/20332404/

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Sep 3, 2021 This Week in Cardiology Podcast Sep 03, 2021

EMPEROR-Preserved, the LOOP study, ablate-and-pace for AF, and salt substitute and stroke: John Mandrola, MD provides a first of two ESC reviews. To read a partial transcript or to comment, visit: https://www.medscape.com/twic

1 - HFpEF

- EMPEROR-Preserved: Empagliflozin Scores HFpEF Breakthrough https://www.medscape.com/viewarticle/957405

- Empagliflozin in Heart Failure with a Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

- Empagliflozin and Major Renal Outcomes in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMc2112411

- Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2022190

2 - AF Screening

- LOOP Trial Undercuts Value of Long-term Continuous ECG Screening for Atrial Fibrillation https://www.medscape.com/viewarticle/957473

- Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01698-6/fulltext

- Subclinical Atrial Fibrillation and the Risk of Stroke https://www.nejm.org/doi/full/10.1056/nejmoa1105575

3 - Ablate and Pace for AF and HF

- APAF-CRT: 'Ablate and Pace' Cuts Mortality in Narrow-QRS HF, Permanent AF https://www.medscape.com/viewarticle/957467

- A randomized controlled trial of atrioventricular junction ablation and cardiac resynchronization therapy in patients with permanent atrial fibrillation and narrow QRS https://academic.oup.com/eurheartj/article/39/45/3999/5078460

- AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial https://doi.org/10.1093/eurheartj/ehab569

4 - Salt Substitute and Stroke

- Salt Substitute Shows Clear Reduction in Stroke, CV Events, and Death https://www.medscape.com/viewarticle/957472

- Effect of Salt Substitution on Cardiovascular Events and Death https://www.nejm.org/doi/full/10.1056/NEJMoa2105675

Features:

- Incremental, Not Monumental, Win for Empagliflozin in Heart Failure With Preserved Ejection Fraction https://www.medscape.com/viewarticle/957465

- Empagliflozin in HFpEF: Putting EMPEROR-Preserved in Context https://www.medscape.com/viewarticle/957388

- Lessons on AF Screening From the LOOP Study https://www.medscape.com/viewarticle/957512

- Ablate-and-Pace Delivers a Huge Win for Those Sick With AF https://www.medscape.com/viewarticle/958033

- Will the Positive Findings From the SSaSS Trial on Salt Substitution Silence the Salt Skeptics? https://www.medscape.com/viewarticle/957510

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Questions or feedback, please contact news@medscape.net

Aug 27, 2021 This Week in Cardiology Podcast Aug 27, 2021

COVID-19, NEJM vaccine safety paper, full-dose anticoagulation in COVID-19, AF and Exercise, and early results on EMPEROR-Preserved are the studies John Mandrola, MD, discusses in this week’s podcast. https://www.medscape.com/twic

1 - COVID-19

- Heart Inflammation More Common After COVID Than After Vaccination https://www.medscape.com/viewarticle/957343

- Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting https://www.nejm.org/doi/full/10.1056/NEJMoa2110475

2 - Full dose AC in COVID-19

- Heparin's COVID-19 Benefit Greatest in Moderately Ill Patients https://www.medscape.com/viewarticle/956630

- Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2105911

- Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2103417

3 - AF and Exercise

- Aerobic Exercise Can Reduce AF Frequency, Severity: ACTIVE-AF https://www.medscape.com/viewarticle/957322

4 - EMPEROR AF

- EMPEROR-Preserved: Empagliflozin Scores HFpEF Breakthrough https://www.medscape.com/viewarticle/957405

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Questions or feedback, please contact news@medscape.net

Aug 20, 2021 This Week in Cardiology Podcast Aug 20, 2021

COVID-19, Simpson’s Paradox, LAA appendage closure, multimorbidity, and an ESC preview are the topics John Mandrola, MD discusses in today’s podcast. https://www.medscape.com/twic

1 - COVID-19

- Lacking Beds, Hospitals Ship COVID-19 Patients to Other States https://www.medscape.com/viewarticle/956917

- Efficacy and Safety of Same-Day Discharge for Atrial Fibrillation Ablation https://pubmed.ncbi.nlm.nih.gov/32553209/

2 - Simpson’s Paradox

- Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated? https://www.covid-datascience.com/post/israeli-data-how-can-efficacy-vs-severe-disease-be-strong-when-60-of-hospitalized-are-vaccinated

- Simpson’s Paradox and Interpreting Data https://towardsdatascience.com/simpsons-paradox-and-interpreting-data-6a0443516765

- How SIMPSON'S PARADOX explains weird COVID19 statistics https://www.youtube.com/watch?v=t-Ci3FosqZs

3 - Left Atrial Appendage Closure

- FDA Approves Abbott's Amplatzer Amulet for Atrial Fibrillation https://www.medscape.com/viewarticle/956726

- Chronic Kidney Disease Tied to Worse LAAO Outcomes https://www.medscape.com/viewarticle/956778

- The Association of Chronic Kidney Disease With Outcomes Following Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/full/10.1016/j.jcin.2021.06.008

- Prophylactic Use of Implantable Cardioverter-Defibrillators in the Prevention of Sudden Cardiac Death in Dialysis https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.039818

4 - ESC Preview

- SGLT2 inhibitors in HFpEF

- EMPEROR-Preserved: Positive Top-Line Results for Empagliflozin in HFpEF https://www.medscape.com/viewarticle/954284

- AF Screening

- Atrial fibrillation detected by continuous electrocardiographic monitoring using implantable loop recorder to prevent stroke in individuals at risk (the LOOP study): Rationale and design of a large randomized controlled trial https://pubmed.ncbi.nlm.nih.gov/28454796/

5 - Coming soon

The anticoagulation in COVID-19 trial is one of the hardest I have seen in years. Stay tuned.

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Questions or feedback, please contact news@medscape.net

Aug 13, 2021 This Week in Cardiology Podcast Aug 13, 2021

COVID-19, vaccine-induced myocarditis, Watchman complications, SGLT2 inhibitors, and cardiogenic shock are the topics John Mandrola, MD, discusses in this week’s podcast. https://www.medscape.com/twic

1 - COVID-19

- 18 Months Later, the COVID-19 Memories Won’t Go Away https://www.medscape.com/viewarticle/956335

2 - Vaccine-Myocarditis

- Myocarditis in Adolescents After COVID-19 Vaccine Typically Mild https://www.medscape.com/viewarticle/956359

- Association of Myocarditis With BNT162b2 Messenger RNA COVID-19 Vaccine in a Case Series of Children https://jamanetwork.com/journals/jamacardiology/fullarticle/2783052

3 - Watchman

- 'Striking' Difference in Adverse Events in Women With Watchman LAAO https://www.medscape.com/viewarticle/956593

- Sex Differences in Procedural Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion https://jamanetwork.com/journals/jamacardiology/fullarticle/2782726

4 - SGLT2 Inhibitors

- EU Approves Dapagliflozin for Kidney Disease, Regardless of Diabetes https://www.medscape.com/viewarticle/956345

- Dapagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2024816

5 - Cardiogenic Shock

- No Win for Milrinone Over Dobutamine in Cardiogenic Shock https://www.medscape.com/viewarticle/956222

- Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock https://www.nejm.org/doi/full/10.1056/NEJMoa2026845

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Questions or feedback, please contact news@medscape.net

Aug 6, 2021 This Week in Cardiology Podcast Aug 06, 2021

The COVID-19 surge, vaccine-induced myocarditis, Heart Rhythm news, the state of medical evidence, and doctors in unions are discussed by John Mandrola, MD, in this week's podcast.

https://www.medscape.com/twic

1- COVID-19

Texas COVID-19 Wave Is Climbing More Steeply Than Past Waves https://www.medscape.com/viewarticle/956104

White House Says US Can Provide COVID-19 Boosters if Needed https://www.medscape.com/viewarticle/956016

2- Vaccine-Myocarditis

Myocarditis Tied to COVID-19 Shots More Common Than Reported? https://www.medscape.com/viewarticle/956089

3- Heart Rhythm News

The Three Big Stories from the Heart Rhythm Society's 2021 Meeting https://www.medscape.com/viewarticle/955989

4- Medical Evidence

Despite Retraction, Study Using Fraudulent Surgisphere Data Still Cited https://www.medscape.com/viewarticle/956090

Ongoing Citations of a Retracted Study Involving Cardiovascular Disease, Drug Therapy, and Mortality in COVID-19 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2782460

5- Doctors in Unions?

Physicians Need to Unionize Now https://www.medscape.com/viewarticle/955888

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Questions or feedback, please contact news@medscape.net

July 30, 2021 This Week in Cardiology Podcast Jul 30, 2021

Two studies on alcohol and AF incidence and an important paper on stable CAD are the topics John Mandrola discusses in this week’s podcast. https://www.medscape.com/twic

1 - COVID-19

New Vaccinations Increasing in COVID Hot Spots https://www.medscape.com/viewarticle/955680

2 - Alcohol

- Moderate Drinking Protective After MI, Stroke in 'Flawed' Study https://www.medscape.com/viewarticle/955474

- Risk Thresholds for Total and Beverage-Specific Alcohol Consumption and Incident Atrial Fibrillation https://doi.org/10.1016/j.jacep.2021.05.013

- Can a Drink a Day Keep the Electrophysiologist Away? https://doi.org/10.1016/j.jacep.2021.06.010

- Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02040-2

3 - Coronary Artery Disease

- CLARIFY Confirms Meds, Watchful Waiting in Angina, Stable CAD https://www.medscape.com/viewarticle/955313

- International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational Observational CLARIFY Study https://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.121.054567

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Questions or feedback, please contact news@medscape.net

Jul 23, 2021 This Week in Cardiology Podcast Jul 23, 2021

COVID-19 messaging, coffee, CTA and statins, and Watchman problems are the topics discussed by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

1- COVID-19:

- COVID-19 Cases in US Triple Over 2 Weeks Amid Misinformation https://www.medscape.com/viewarticle/955269

- Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant https://www.nejm.org/doi/full/10.1056/NEJMoa2108891

- What Really Happened With that Weird Yankees COVID Outbreak https://nymag.com/intelligencer/2021/05/what-really-happened-with-that-weird-yankees-covid-outbreak.html

2- Coffee:

- Coffee Not Linked to Increased Arrhythmia Risk in New Study https://www.medscape.com/viewarticle/954992

- Coffee Consumption and Incident Tachyarrhythmias https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2782015

- Another Cup of Coffee Without an Arrhythmia, Please https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2782021

3- CTA and Statins:

- CTA May Guide Primary Prevention Statins in Nonobstructive CAD https://www.medscape.com/viewarticle/955030

- Reduction of Myocardial Infarction and All-Cause Mortality Associated to Statins in Patients Without Obstructive CAD https://www.jacc.org/doi/full/10.1016/j.jcmg.2021.05.022

4- Left Atrial Appendage Closure:

- Five Risk Factors May Predict Thrombus on LAA Occlusion Implants https://www.medscape.com/viewarticle/955131

- Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion https://www.jacc.org/doi/full/10.1016/j.jacc.2021.04.098

- Device-Related Thrombus After Left Atrial Appendage Occlusion https://www.jacc.org/doi/10.1016/j.jacc.2021.05.028

Features:

- Does Coffee Make Your Heart Flutter? https://www.medscape.com/viewarticle/954996

- Enough With the Coffee Research and Other Distractions https://www.medscape.com/viewarticle/883709

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Questions or feedback, please contact news@medscape.net

July 16, 2021 This Week in Cardiology Podcast Jul 16, 2021

COVID-19, Ivermectin, a dissolving pacer, clinician well-being, and finerenone are discussed this week.

1 COVID-19

US 'Losing Time' Against Delta Variant, NIH Chief Says https://www.medscape.com/viewarticle/954882

Ivermectin for COVID: How Do We Know What to Believe? https://www.medscape.com/viewarticle/954681

2 Dissolving Pacemaker

Dissolving Pacemaker Impressive in Early Research https://www.medscape.com/viewarticle/954774

3 Clinician Well-being

Global Heart Organizations Unite to Promote Clinician Well-Being https://www.medscape.com/viewarticle/954803

Clinician Well-Being: Addressing Global Needs for Improvements in the Health Care Field A Joint Opinion From the American College of Cardiology, American Heart Association, European Society of Cardiology, and the World Heart Federation https://www.jacc.org/toc/jacc/0/0

From Triple to Quadruple Aim: Care of the Patient Requires Care of the Provider https://www.annfammed.org/content/12/6/573.full

Bullying in Academic Medicine Rife, Underreported https://www.medscape.com/viewarticle/954709

4 Finerenone

FDA Approves Finerenone (Kerendia) for Slowing CKD in Type 2 Diabetes https://www.medscape.com/viewarticle/954606

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Questions or feedback, please contact news@medscape.net

July 2, 2021 This Week in Cardiology Podcast Jul 02, 2021

COVID-19, mRNA-vaccine-induced myocarditis, type 2 diabetes in kids, optimal medical therapy for CAD, and Alcohol are the topics discussed by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

1-COVID

- Fast-spreading Delta Variant, Vaccination Rates, Reintroduction of Indoor Masks: COVID-19 Global Weekly Highlights https://www.medscape.com/viewarticle/940446

- Health care 'breaking point': Cox confirms some Springfield COVID-19 patients transferred to St. Louis, Kansas City https://www.news-leader.com/story/news/local/ozarks/2021/06/29/springfield-covid-delta-variant-missouri-hospitals-cox-some-patients-transferred-vaccines/7787970002/

2- COVID Vaccine-Induced Myocarditis

- New Details of Myocarditis Linked to COVID Vaccines https://www.medscape.com/viewarticle/954061

- Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military https://jamanetwork.com/journals/jamacardiology/fullarticle/2781601

- Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination https://jamanetwork.com/journals/jamacardiology/fullarticle/2781602

3- Diabetes in the Clinic

- 'Staggering' Doubling of Type 2 Diabetes in Kids During Pandemic https://www.medscape.com/viewarticle/953816

4- Optimal Medical Therapy

- OMT 'Best Insurance' for Extended Survival After Revascularization https://www.medscape.com/viewarticle/953959

- Impact of Optimal Medical Therapy on 10-Year Mortality After Coronary Revascularization https://doi.org/10.1016/j.jacc.2021.04.087

- Defining the Proper SYNTAX for Long-Term Benefit of Myocardial Revascularization With Optimal Medical Therapy https://doi.org/10.1016/j.jacc.2021.04.088

- Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease. https://www.nejm.org/doi/full/10.1056/nejmoa0804626

- Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial https://doi.org/10.1016/S0140-6736(19)31997-X

5- Alcohol

- The Sick-Quitter Effect: How Alcohol Can Seem Cardioprotective When It Isn't https://www.medscape.com/viewarticle/953696

Features:

- Vaccine-Induced Myocarditis Concerns Demand Respect, Not Absolutism https://www.medscape.com/viewarticle/954038

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Questions or feedback, please contact news@medscape.net

Jun 25, 2021 This Week in Cardiology Podcast Jun 25, 2021

Myocarditis and the COVID vaccine, lipid lowering guidelines, financial toxicity, and deprescribing statins are the topics covered by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

1 – COVID

Varied COVID Vaccination Rates May Lead to 'Two Americas' https://www.medscape.com/viewarticle/953658

Nearly All COVID Deaths in US Are Now Among Unvaccinated https://www.medscape.com/viewarticle/953703

2 - COVID Vaccine Myocarditis

FDA to Add Myocarditis Warning to mRNA COVID-19 Vaccines https://www.medscape.com/viewarticle/953647

3 – Lipid Guidelines

Clinicians Slow to Implement Lipid-Lowering Guidelines: GOULD Registry https://www.medscape.com/viewarticle/953688

- Use of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US https://jamanetwork.com/journals/jamacardiology/fullarticle/2780713

4 - Financial Toxicity

Financial Burden Higher With CVD Than Cancer https://www.medscape.com/viewarticle/953687

- Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States https://www.jacc.org/doi/10.1016/j.jaccao.2021.02.006

5 - Deprescribing Statins

Stopping Statins Linked to Death, CV Events in Elderly https://www.medscape.com/viewarticle/953545

- Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2780952

- Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61240-4/fulltext

- Rosuvastatin in Older Patients with Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa0706201

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Questions or feedback, please contact news@medscape.net

June 18, 2021 This Week in Cardiology Jun 18, 2021

COVID vaccine myocarditis, Christian Eriksen and sudden cardiac death, therapeutic hypothermia, and revascularization of stable CAD are the topics John Mandrola, MD, discusses in this week’s podcast.

https://www.medscape.com/twic

1- COVID-Vaccine-Myocarditis

AHA: Don't Delay COVID Shot While CDC Reviews Myocarditis Cases https://www.medscape.com/viewarticle/953233

Myocarditis after BNT162b2 and mRNA-1273 Vaccination https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055913

2- Christian Eriksen

Christian Eriksen: un survivant qui doit nous inspirer

https://francais.medscape.com/voirarticle/3607279

Danish Soccer Player Suffered Cardiac Arrest During Euro Match

https://www.webmd.com/news/20210614/danish-soccer-player-suffered-cardiac-arrest-during-euro-match

Point/Counterpoint on Halting Implantation of the Subcutaneous ICD https://www.jacc.org/doi/10.1016/j.jacep.2021.03.006

3- Therapeutic Hypothermia

Trial Supports Therapeutic Hypothermia in Nonshockable Cardiac Arrest https://www.medscape.com/viewarticle/919855

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

https://www.nejm.org/doi/full/10.1056/NEJMoa2100591

PulmCrit – A history of hypothermia for cardiac arrest, 2002-2021 (RIP)

https://emcrit.org/pulmcrit/ttm2/

4 - Revascularization of Stable CAD

Meta-analysis Muses Over ISCHEMIA Message Had Trial Lasted Longer https://www.medscape.com/viewarticle/951498

Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis https://doi.org/10.1093/eurheartj/ehab246

Impact of revascularisation on outcomes in chronic coronary syndromes: a new meta-analysis with the same old biases?

https://doi.org/10.1093/eurheartj/ehab330

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https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact

news@medscape.net

June 11, 2021 This Week in Cardiology Podcast Jun 11, 2021

COVID vaccine myocarditis, AF post-stroke, semaglutide, and iPhones and cardiac devices are the topics John Mandrola, MD, discusses in this week’s podcast. https://www.medscape.com/twic

COVID-Vaccine-Myocarditis

More Evidence Links COVID Vaccines to Rare Cases of Myocarditis in Youth https://www.medscape.com/viewarticle/952905

- Symptomatic Acute Myocarditis in Seven Adolescents Following the Pfizer-BioNTech COVID-19 Vaccination https://pediatrics.aappublications.org/content/early/2021/06/04/peds.2021-052478

- At Least 18 Cases of Apparent Heart Problems in Young People in CT After COVID-19 Vaccine https://www.nbcconnecticut.com/news/coronavirus/connecticut-confirms-at-least-18-cases-of-apparent-heart-problems-in-young-people-after-covid-19-vaccination/2494534/

- C.D.C. Is Investigating a Heart Problem in a Few Young Vaccine Recipients https://www.nytimes.com/2021/05/22/health/cdc-heart-teens-vaccination.html

- EMA Statement: https://www.ema.europa.eu/en/news/meeting-highlights-pharmacovigilance-risk-assessment-committee-prac-3-6-may-2021

- Is the Second Shot Giving Young Men a Dangerous Heart Condition? https://nymag.com/intelligencer/2021/06/israel-detects-link-between-myocarditis-and-covid-vaccine.html

- Report to FDA https://www.fda.gov/media/150054/download

AF and Stroke

Evidence Mounts for Implantable AF Monitoring After Stroke https://www.medscape.com/viewarticle/952325

- The STROKE-AF Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2780490

- The PER DIEM Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2780491

Obesity

FDA Approves 'Game Changer' Semaglutide for Weight Loss https://www.medscape.com/viewarticle/952441

iPhone 12 and Cardiac Device

Evidence Builds for iPhone 12 Interference With Cardiac Devices https://www.medscape.com/viewarticle/952780

- Magnetic Interference on Cardiac Implantable Electronic Devices From Apple iPhone MagSafe Technology https://www.ahajournals.org/doi/10.1161/JAHA.121.020818

- Letter to the Editor—Lifesaving therapy inhibition by phones containing magnets https://www.heartrhythmjournal.com/article/S1547-5271(20)31227-3/fulltext

- Smart wearable device accessories may interfere with implantable cardiac devices https://www.heartrhythmcasereports.com/article/S2214-0271(20)30274-8/fulltext

Features:

Feb 26, 2021 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/946476

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Questions or feedback, please contact news@medscape.net

May 21, 2021 This Week in Cardiology Podcast May 21, 2021

John Mandrola, MD, presents an ACC 2021 recap. https://www.medscape.com/twic

ACC 2021 Reveiw

I -- Left Atrial Appendage Closure

LAAOS III: Surgical LAA Closure Cuts AF Stroke Risk by One Third https://www.medscape.com/viewarticle/951232

- Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke https://www.nejm.org/doi/full/10.1056/NEJMoa2101897

Watchman Registry: 1-Year Stroke Estimates Reassuringly Low https://www.medscape.com/viewarticle/951235

II - Angiotensin-Neprilysin Inhibition

PARADISE-MI: Sacubitril/Valsartan Can't Beat Ramipril in Patients With Acute MI https://www.medscape.com/viewarticle/951236

Life Trial

Rationale Paper: https://doi.org/10.1016/j.jchf.2020.05.005

III - Renal Denervation

Ultrasound Renal Denervation Drops BP in Patients on Triple Therapy https://www.medscape.com/viewarticle/951248

IV -- Clopidogrel vs ASA post Stent

HOST-EXAM: Clopidogrel Beats Aspirin as Monotherapy After Stenting https://www.medscape.com/viewarticle/951294

- Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial https://doi.org/10.1016/S0140-6736(21)01063-1

V -- AF Ablation in HF

RAFT-AF, Despite Itself, Hints at Advantage for Ablation Rhythm Control in Heart Failure With AF. https://www.medscape.com/viewarticle/951326

VI -- Rivaroxaban in COVID-19 – ACTION Trial

Therapeutic Rivaroxaban Dose: Risk Outweighs Benefit in Stable COVID https://www.medscape.com/viewarticle/951475

VII -- REHAB-HF Trial

Novel Rehab Program Fights Frailty, Boosts Capacity in Advanced HF https://www.medscape.com/viewarticle/951244

- Physical Rehabilitation for Older Patients Hospitalized for Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2026141

VIII – ASA 81 vs 325 – ADAPTABLE Trial

ADAPTABLE: Low-Dose Aspirin as Good as High-Dose in CHD? https://www.medscape.com/viewarticle/951230

- Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2102137

Perspectives:

Eight Things to Know About the Surgical Left Atrial Appendage Occlusion (LAAOS III) Trial https://www.medscape.com/viewarticle/951229

PARADISE-MI Makes Me Question the Benefits of Sacubitril/Valsartan https://www.medscape.com/viewarticle/951239

Sacubitril/Valsartan: Trending Toward PARADISE Post MI https://www.medscape.com/viewarticle/950300

Renal Denervation for Resistant Hypertension Is Not Back on Track https://www.medscape.com/viewarticle/951497

Acute Alcohol Consumption Raises Risk for Atrial Fibrillation https://www.medscape.com/viewarticle/950938

Does ADAPTABLE Inform Aspirin Dosing for Secondary Prevention? https://www.medscape.com/viewarticle/950969

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May 14, 2021 This Week in Cardiology Podcast May 14, 2021

The upcoming ACC meeting, polypharmacy, finerenone, and ethics and professionalism are the topics covered by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

ACC Preview:

ACC.21 Looks to Repeat Success Despite Pandemic Headwinds https://www.medscape.com/viewarticle/950836

- Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/31050775/

Polypharmacy

Hypertension Worsened by Commonly Used Prescription Meds https://www.medscape.com/viewarticle/950724

Finerenone

Finerenone Scores Second Pivotal-Trial Success in Diabetic Kidney Disease https://www.medscape.com/viewarticle/951027

- Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2025845

Ethics and Professionalism

AHA/ACC Guidance on Ethics, Professionalism in Cardiovascular Care https://www.medscape.com/viewarticle/951018

- 2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report https://www.ahajournals.org/doi/10.1161/CIR.0000000000000963

Features:

Mandrola Previews the 2021 (Virtual) American College of Cardiology Scientific Sessions https://www.medscape.com/viewarticle/950797

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May 7, 2021 This Week in Cardiology Podcast May 07, 2021

COVID-19 and BMI, TAVR vs SAVR, subcutaneous ICD, SGLT2 inhibitors, and physician-Moms are the topics John Mandrola, MD, discusses in this week’s podcast. https://www.medscape.com/twic

COVID-19

COVID-19 Severity Starts in Normal BMI Range, Especially in Young https://www.medscape.com/viewarticle/950568

- Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00089-9/fulltext

TAVR vs SAVR

VARC-3 Sets Goalpost for Future Aortic Valve Trials https://www.medscape.com/viewarticle/950012

- Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa799/6237954

TAVR Availability

Patchy Growth of TAVR Programs Leaves Poorer Communities Behind https://www.medscape.com/viewarticle/950316

S-ICD

Trade-offs Between Subcutaneous, Transvenous ICDs on Display in EFFORTLESS https://www.medscape.com/viewarticle/950328

- Implant and Midterm Outcomes of the Subcutaneous Implantable Cardioverter-Defibrillator Registry: The EFFORTLESS Study https://doi.org/10.1016/j.jacc.2017.06.040

- Reduction in Inappropriate Therapy and Mortality through ICD Programming https://www.nejm.org/doi/full/10.1056/NEJMoa1211107

- Low inappropriate shock rates in patients with single- and dual/triple-chamber implantable cardioverter-defibrillators using a novel suite of detection algorithms: PainFree SST trial primary results https://doi.org/10.1016/j.hrthm.2015.01.017

Dapagliflozin and CKD

FDA Approves Dapagliflozin (Farxiga) for Chronic Kidney Disease https://www.medscape.com/viewarticle/950329

Features

New Physician Moms Need More Resources and Less Guilt in the Workplace https://www.medscape.com/viewarticle/949765

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Apr 30, 2021 This Week in Cardiology Podcast Apr 30, 2021

COVID-19 and global vaccinations, AF screening, conduction-system pacing, FDA ban on menthol tobacco, and a heartfelt essay are the topics John Mandrola, MD, discusses in this week’s podcast. https://www.medscape.com/twic

COVID-19

Indians Rush for COVID-19 Vaccines as Death Toll Passes 200,000 https://www.medscape.com/viewarticle/950095

- Vaccine Breakthrough Infections with SARS-CoV-2 Variants https://www.nejm.org/doi/full/10.1056/NEJMoa2105000

AF Screening:

Modest Clinical Gain for AF Screening of Asymptomatic Elderly: STROKESTOP https://www.medscape.com/viewarticle/949950

- Mass Screening for Untreated Atrial Fibrillation

The STROKESTOP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.014343

- Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials https://pubmed.ncbi.nlm.nih.gov/25596211/

- Toward evidence-based medical statistics. 2: The Bayes factor https://pubmed.ncbi.nlm.nih.gov/10383350

Conduction System Pacing

Keeping Pace: His-Bundle CRT for Heart Failure Impresses in Second Randomized Trial https://www.medscape.com/viewarticle/950037

- A Randomized Trial of His pacing versus Biventricular pacing in Symptomatic Heart Failure Patients with left bundle branch block (His-Alternative) https://www.jacc.org/doi/10.1016/j.jacep.2021.04.003

- His Corrective Pacing or Biventricular Pacing for Cardiac Resynchronization in Heart Failure https://www.jacc.org/doi/full/10.1016/j.jacc.2019.04.026

FDA

FDA Moves to Ban Menthol in Tobacco Products https://www.medscape.com/viewarticle/950223

Features:

Losing Both Parents During COVID: A Physician's 'Unwitnessed Grief' https://www.medscape.com/viewarticle/949490

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Apr 23, 2021 This Week in Cardiology Podcast Apr 23, 2021

Cardiac status post COVID-19 in athletes, AF ablation, and bias against procedural doctors are the topics covered by John Mandrola, MD, in this week’s podcast https://www.medscape.com/twic

COVID-19

COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021 https://www.cdc.gov/mmwr/volumes/70/wr/mm7017e2.htm

Professor Zeynep Tufekci Newsletter: https://www.theinsight.org/p/facts-are-pieces-of-a-puzzle-not

Post-COVID-19 Cardiac Involvement in NCAA athletes

SARS-CoV-2 Cardiac Involvement in Young Competitive Athletes https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.054824

AF and Durable PV isolation

Paroxysmal AF Can Recur but Burden Plunges After 'Durable' Ablation https://www.medscape.com/viewarticle/949566

Radiofrequency vs. Cryoballoon Catheter Ablation for Paroxysmal Atrial Fibrillation: Durability of Pulmonary Vein Isolation and Effect on AF Burden: The RACE-AF Randomized Controlled Trial https://www.ahajournals.org/doi/10.1161/CIRCEP.120.009573

Bias Against Procedures:

Apr 9, 2021 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/949000

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Apr 16, 2021 This Week in Cardiology Podcast Apr 16, 2021

COVID-19 vaccine-related clotting, vitamin D, anticoagulation strategies before PCI, and a good intervention at end of life are the topics John Mandrola, MD, discusses in this week’s podcast. https://www.medscape.com/twic

COVID-19:

How Some COVID-19 Vaccines Could Cause Rare Blood Clots https://www.medscape.com/viewarticle/949262

FAQ: What to Know About the J&J Vaccine Pause https://www.medscape.com/viewarticle/949231

Vitamin D Screening:

Don't Screen for Vitamin D in General Population, Says US Task Force https://www.medscape.com/viewarticle/949167

Pre-PCI AC Decisions:

Parity Whether Anticoagulation Is Halted or Not for Unplanned Cath https://www.medscape.com/viewarticle/949064

Uninterrupted Oral Anticoagulant Therapy in Patients Undergoing Unplanned Percutaneous Coronary Intervention https://doi.org/10.1016/j.jcin.2021.01.022

Pacemaker or Defibrillator Surgery without Interruption of Anticoagulation https://www.nejm.org/doi/full/10.1056/nejmoa1302946

Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2) https://doi.org/10.1093/eurheartj/ehy413

A Superb Intervention at End of Life:

Use of Comfort Care Increasing After Stroke, May Reduce Costs https://www.medscape.com/viewarticle/949297

Decade‐Long Nationwide Trends and Disparities in Use of Comfort Care Interventions for Patients With Ischemic Stroke https://doi.org/10.1161/JAHA.120.019785

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Apr 9, 2021 This Week in Cardiology Podcast Apr 09, 2021

COVID-19, COVID-19 vaccines, hybrid AF ablation TAVR and who gets to be called a doctor are the topics by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

COVID-19

UK Regulators to Offer Under-30s Alternative to AZ COVID Vaccine https://www.medscape.com/viewarticle/948934

- News - Communicating the potential benefits and harms of the Astra-Zeneca COVID-19 vaccine https://wintoncentre.maths.cam.ac.uk/news/communicating-potential-benefits-and-harms-astra-zeneca-covid-19-vaccine/

Hybrid Ablation for Persistent AF

- Hybrid Convergent Procedure for the Treatment of Persistent and Long-Standing Persistent Atrial Fibrillation https://www.ahajournals.org/doi/10.1161/CIRCEP.120.009288

- Converge trial Rationale Paper https://doi.org/10.1016/j.ahj.2020.02.016

- Approaches to Catheter Ablation for Persistent Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa1408288

- Toward evidence-based medical statistics. 2: The Bayes factor https://pubmed.ncbi.nlm.nih.gov/10383350/

TAVR

- TAVR Feasible, Comparable to Surgery in Rheumatic Heart Disease https://www.medscape.com/viewarticle/948832

- Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Rheumatic Aortic Stenosis https://doi.org/10.1016/j.jacc.2021.02.032

- Upsides, Downsides for TAVR, Minimally Invasive AVR https://www.medscape.com/viewarticle/946104

- Minimally invasive surgery versus transcatheter aortic valve replacement: a systematic review and meta-analysis https://openheart.bmj.com/content/8/1/e001535#ref-9

Who Should Get to Be Called 'Doctor'? https://www.medscape.com/viewarticle/948887

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April 2, 2021 This Week in Cardiology Apr 02, 2021

COVID-19, long-COVID, the language of medicine, childhood obesity, and open notes are the topics covered by John Mandrola, MD, in this week's podcast.

https://www.medscape.com/twic

COVID-19

AstraZeneca COVID Vaccine: Clotting Disorder Mechanism Revealed?

https://www.medscape.com/viewarticle/948560

Long COVID

Long COVID Brings Welcome Attention to POTS

https://www.medscape.com/viewarticle/948174

Keep Both 'Renal' and 'Nephro' in Glossary of Kidney Disease

https://www.medscape.com/viewarticle/948451

'Striking' Increase in Childhood Obesity During Pandemic

https://www.medscape.com/viewarticle/948350

COVID-19 and Changes in Child Obesity. https://pediatrics.aappublications.org/content/early/2021/03/01/peds.2021-050123

Starting Monday, Patients Can Read Your Notes:

5 Key Things https://www.medscape.com/viewarticle/948508

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https://www.medscape.com/author/bob-harrington

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Mar 26, 2021 This Week in Cardiology Podcast Mar 26, 2021

COVID-19, AF detection post stroke, new measures of heart function, and structural racism in quality measures are the topics covered by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

COVID-19

NIH Rebukes AstraZeneca Vaccine Interim Data: 'Incomplete' https://www.medscape.com/viewarticle/947954

Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination https://jamanetwork.com/journals/jama/fullarticle/2777898

AF and Stroke

Insertable Cardiac Monitors Improve AF Detection After Stroke https://www.medscape.com/viewarticle/947986

Perfection in LV Function Measurement

Adding Strain Measure to LVEF Better Predicts Later HF https://www.medscape.com/viewarticle/948114

Association of Left Ventricular Systolic Function With Incident Heart Failure in Late Life https://jamanetwork.com/journals/jamacardiology/fullarticle/2777414

Is the Left Ventricular Ejection Fraction Measurement Still Preeminent?—New Measures to Quantify Subclinical Systolic Dysfunction https://jamanetwork.com/journals/jamacardiology/fullarticle/2777412

Structural Racism in Pay for Performance

Association Between the Proportion of Black Patients Cared for at Hospitals and Financial Penalties Under Value-Based Payment Programs https://jamanetwork.com/journals/jama/fullarticle/2777701

Twitter Thread from Rishi Wadhera https://twitter.com/rkwadhera/status/1374380385560186883

References:

Sowell, Thomas A Conflict of Visions https://en.wikipedia.org/wiki/A_Conflict_of_Visions

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Mar 19, 2021 This Week in Cardiology Podcast Mar 19, 2021

COVID-19, Fish Oil and AF risk, SGLT2 inhibitors and renal outcomes, and TAVR vs SAVR are the topics discussed by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

COVID-19

EMA Launches Review of Clot Risk With AstraZeneca COVID Vaccine https://www.medscape.com/viewarticle/947393

AZ Vaccine Safe Overall but Questions Remain over Unusual Clots https://www.medscape.com/viewarticle/947733

Fish Oil and AF

Dose-Related AF Risk With Omega-3 Fatty Acids? https://www.medscape.com/viewarticle/947542

Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2777469

Omega-3 Fatty Acids and Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2777450

SGLT2i and Renal Outcomes

Ertugliflozin: Renal Benefits in Additional VERTIS CV Analyses https://www.medscape.com/viewarticle/947668

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2004967

Effects of ertugliflozin on kidney composite outcomes, renal function and albuminuria in patients with type 2 diabetes mellitus: an analysis from the randomised VERTIS CV trial https://link.springer.com/article/10.1007/s00125-021-05407-5

TAVR vs SAVR

TAVR vs SAVR in Low-Risk Patients: What We Do and Don't Know https://www.medscape.com/viewarticle/946173

Mortality in trials on transcatheter aortic valve implantation versus surgical aortic valve replacement: a pooled meta-analysis of Kaplan-Meier-derived individual patient data https://pubmed.ncbi.nlm.nih.gov/32236543/

Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk https://www.jacc.org/doi/full/10.1016/j.jacc.2020.12.052

Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement https://www.nejm.org/doi/full/10.1056/NEJMoa1910555

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March 12, 2021 This Week in Cardiology Podcast Mar 12, 2021

COVID-19, heart failure classifications, DOAC after bioprosthetic valves, and Medicare spending in the pandemic year Are the topics discussed by John Mandrola, MD, in this week’s podcast. https://www.medscape.com/twic

I. COVID-19 Vaccination in Israel

COVID-19 Vaccination Linked to Less Mechanical Ventilation https://www.medscape.com/viewarticle/946568

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting https://www.nejm.org/doi/full/10.1056/NEJMoa2101765

II. Heart Failure Classification

Heart Failure Redefined With New Classifications, Staging https://www.medscape.com/viewarticle/947048

Universal Definition and Classification of Heart Failure: A Report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure https://doi.org/10.1016/j.cardfail.2021.01.022

Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa1908655

Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.044586

III. DOACs In Bioprosthetic Valves --

DOACs Offered After Heart Valve Surgery Despite Absence of Data https://www.medscape.com/viewarticle/947193

Off-label Use of Direct Oral Anticoagulants in Patients Receiving Surgical Mechanical and Bioprosthetic Heart Valves https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777141

Dabigatran versus Warfarin in Patients with Mechanical Heart Valves https://www.nejm.org/doi/full/10.1056/nejmoa1300615

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000665

Antithrombotic therapy in atrial fibrillation associated with valvular heart disease: a joint consensus document.... https://academic.oup.com/europace/article/19/11/1757/4098134

IV. Pandemic Slices Medicare Physician Spending in First Half of 2020: AMA https://www.medscape.com/viewarticle/946984

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March 5, 2021 This Week in Cardiology Podcast Mar 05, 2021

Cardiac studies in professional athletes after COVID-19 infection, percutaneous valve repair, AF screening, and social media are the topics discussed by John Mandrola, MD, in this week’s podcast. To read a partial transcript or to comment https://www.medscape.com/twic

COVID and the Athletic Heart

Incidence of Cardiac Pathology Post-COVID in Pro Athletes < 1% https://www.medscape.com/viewarticle/946902

Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening https://jamanetwork.com/journals/jamacardiology/fullarticle/2777308

Percutaneous Valve Repair

Delirium Common, Costly After Mitral, Tricuspid Valve Repair https://www.medscape.com/viewarticle/946736

Prevalence and Impact of Post-Procedural Delirium After Percutaneous Repair of Mitral and Tricuspid Valves https://www.jacc.org/doi/full/10.1016/j.jcin.2020.11.031

AF Screening

AF Screening in Asymptomatic Older Individuals Shows Promise https://www.medscape.com/viewarticle/946844

Screening for Atrial Fibrillation in the Older Population A Randomized Clinical Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2776728

Social Media

JAMA Podcast on Racism in Medicine Faces Backlash https://www.webmd.com/sex-relationships/news/20210304/jama-podcast-on-racism-in-medicine-faces-backlash

Time's Up Founder Choo Accused in Harassment Mishandling https://www.medscape.com/viewarticle/946678

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Feb 26, 2021 This Week in Cardiology Podcast Feb 26, 2021

Risk factors for COVID-19, CMR after COVID-19, and two important obesity studies are discussed in this week’s podcast. To read a partial transcript or to comment https://www.medscape.com/twic

Cardiometabolic Conditions and COVID19

Most Severe COVID Tied to Four Cardiometabolic Conditions https://www.medscape.com/viewarticle/946488

Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis https://www.ahajournals.org/doi/10.1161/JAHA.120.019259

CMR after COVID19

Myocardial Injury Seen on MRI in 54% of Recovered COVID https://www.medscape.com/viewarticle/946287

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance https://doi.org/10.1093/eurheartj/ehab075

Obesity Trials

Semaglutide for Weight Loss? A Good First STEP, With Caveats https://www.medscape.com/viewarticle/945630

Once-Weekly Semaglutide in Adults with Overweight or Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Major Breakthrough in Weight Loss With Semaglutide? https://www.medscape.com/viewarticle/940841

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity https://jamanetwork.com/journals/jama/fullarticle/2777025

Features

Fired for Good Judgment a Sign of Physicians' Lost Respect https://www.medscape.com/viewarticle/946286

A Tribute to Bernard Lown https://www.medscape.com/viewarticle/946447

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Feb 19, 2021 This Week in Cardiology Podcast Feb 19, 2021

Bernard Lown, Type 2 MI, Sacubitril/Valsartan and COVID19 anticoagulation are discussed in this week’s podcast. To read a partial transcript or to comment https://www.medscape.com/twic

COVID

Israeli Study Finds Pfizer Vaccine 95% Effective Against COVID-19 https://www.medscape.com/viewarticle/945962

Bernard Lown

Cardiologist, Antiwar Activist Bernard Lown Dies at 99 https://www.medscape.com/viewarticle/945966

Type 2 MI

New Light Cast on Type-2 MI Aims to Sharpen Diagnosis, Therapy https://www.medscape.com/viewarticle/946075

Early AC in COVID19

More Evidence Supports Early Anticoagulation in COVID-19 https://www.medscape.com/viewarticle/945902

Sacubitril/Valsartan

FDA Expands Sacubitril/Valsartan Indication to Embrace Some HFpEF https://www.medscape.com/viewarticle/945936

Five Reasons Sacubitril/Valsartan Should NOT Be Approved for HFpEF https://www.medscape.com/viewarticle/944168

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Feb 12, 2021 This Week in Cardiology Podcast Feb 12, 2021

Prediabetes, AI and ECGs, HFpEF, and observational studies are the topics discussed by John Mandrola, MD in this week’s podcast. To read a partial transcript or to comment http://www.medscape.com/twic

Pre-diabetes

'Prediabetes' Unlikely to Progress to Diabetes in Older Adults https://www.medscape.com/viewarticle/945511

Mobile QT Interval Measurement

Using AI, Mobile ECG Aims to Expand QTc Screening Horizons https://www.medscape.com/viewarticle/945484 Giudicessi JR et al.

Artificial Intelligence-Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device | Circulation (ahajournals.org) https://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.120.050231

HFpEF

Exercise Quandary in HFpEF: Training Regimens Fall Short in Trial https://www.medscape.com/viewarticle/945621

Observational Study Follies

Statins Linked to Reduced Postop Adhesions, Bowel Obstruction https://www.medscape.com/viewarticle/945686

You may also like:

Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine

The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Feb 5, 2021 This Week in Cardiology Podcast Feb 05, 2021

Carotid screening, AF and alcohol, subcutaneous ICD, and medical education are the topics discussed by John Mandrola, MD, in this week’s podcast. To read a partial transcript or to comment http://www.medscape.com/twic

Carotid Screening

USPSTF Again Recommends Against Carotid Stenosis Screening https://www.medscape.com/viewarticle/945202

Subcutaneous ICD Recall

FDA Recalls Subcutaneous-ICD Leads Due to Fracture Risk https://www.medscape.com/viewarticle/945168

Alcohol and AF

Alcohol and the Electric Atrium, Part 2: When BAC Exceeds the Legal Limit https://www.medscape.com/viewarticle/945297

Medical Education

USMLE Stuns Again: Clinical Skills Test Permanently Ended https://www.medscape.com/viewarticle/944756

You may also like:

Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine

The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Jan 29, 2021 This Week in Cardiology Podcast Jan 29, 2021

AF and COVID-19, microthrombi in COVID-19 autopsies, vericiguat, and POTS are the topics covered by John Mandrola, MD, in this week’s podcast. To read a partial transcript or to comment: http://www.medscape.com/twic

AF and COVID

AF at COVID-19 Admission Predicts Mortality, Demands Vigilance https://www.medscape.com/viewarticle/944802

Microthrombi and COVID

Microthrombi, Necrosis Seen in COVID-19 Hearts on Autopsy https://www.medscape.com/viewarticle/944783

Vericiguat

FDA Approval Adds Vericiguat (Verquvo) to HF Treatment Options https://www.medscape.com/viewarticle/944434

POTS:

Lower-Body Compression Trims Orthostatic Tachycardia in POTS https://www.medscape.com/viewarticle/944791

Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment https://doi.org/10.1016/j.pcad.2020.03.010

Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance https://www.onlinecjc.ca/article/S0828-282X(19)31550-8/fulltext#secsectitle0130

You may also like:

Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine

https://www.medscape.com/features/public/machine

The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.

https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Jan 22, 2021 This Week in Cardiology Podcast Jan 22, 2021

COVID myocarditis, the Polypill, low-value care, and edge-to-edge tricuspid valve repair are discussed by John Mandrola, MD, in this week’s podcast.

Jan 15, 2021 This Week in Cardiology Podcast Jan 15, 2021

COVID, ACE/ARBs, left atrial appendage closure, SGLT2 inhibitors, and a clue in AF mechanisms are the topics discussed by John Mandrola, MD, in this week’s podcast.

Jan 8, 2021 This Week in Cardiology Podcast Jan 08, 2021

COVID vaccine schedules, trial translation, valve guidelines, and physician harassment on social media are the topics discussed by John Mandrola, MD, in this week’s podcast.

Dec 18, 2020 This Week in Cardiology Podcast Dec 18, 2020

COVID, sacubitril/valsartan and spironolactone in patients with HFpEF, year-end comments are the topics discussed by John Mandrola, MD in this week’s podcast.

Dec 11, 2020 This Week in Cardiology Podcast Dec 11, 2020

COVID, the clogged pipe frame of CAD, paclitaxel, and AF performance measures and Goodhart’s law are the topics John Mandrola, MD, covers in this week’s podcast.

Dec 4, 2020 This Week in Cardiology Podcast Dec 04, 2020

COVID vaccines, tocilizumab, finerenone, type 2 MI care, coronary CTA, and sotagliflozin are the topics discussed by John Mandrola, MD, in this week’s podcast.

Nov 20, 2020 This Week in Cardiology Podcast Nov 20, 2020

COVID-19 vaccines and virtual AHA presentations on statins and the nocebo effect, high dose omega-3s, and AF ablation are the topics John Mandrola, MD, discusses on this week’s podcast.

Nov 13, 2020 This Week in Cardiology Podcast Nov 13, 2020

COVID19 vaccines, thrombolysis in stroke, industry payments to doctors, and the upcoming AHA are topics covered by John Mandrola, MD, in this week’s podcast.

Nov 6, 2020 This Week in Cardiology Podcast Nov 06, 2020

COVID, AF ablation, pediatric “do not dos” from AAP, heart failure performance measures, and a brief AHA preview are the topics discussed by John Mandrola, MD on this week’s podcast.

Oct 30, 2020 This Week in Cardiology Podcast Oct 30, 2020

Remdesivir, the athletic heart, troponin and echo abnormalities in patients with COVID-19, and a novel MRA drug are the topics John Mandrola, MD, discusses in this week's podcast

Oct 23, 2020 This Week in Cardiology Podcast Oct 23, 2020

COVID, tocilizumab, hypertrophic cardiomyopathy, cerebral microbleeds, and surrogate endpoints are the topics discussed by John Mandrola, MD, in this week’s podcast

Oct 16, 2020 This Week in Cardiology Podcast Oct 16, 2020

COVID drug trials and science news, BNP, polypharmacy in heart failure, and in-patient CPR are the topics john Mandrola, MD, discusses in this week’s podcast

Oct 9, 2020 This Week in Cardiology Podcast Oct 09, 2020

COVID-19, scientific philosophy, left main coronary artery disease, empagliflozin and the SGLT2 inhibitors are the topics discussed by John Mandrola, MD in this week’s podcast

Oct 2, 2020 This Week in Cardiology Podcast Oct 02, 2020

Scientific trust, publishing incentives, and the EXCEL trial, Vitamin D and COVID, and time-restricted eating are discussed by John Mandrola, MD, in this week’s podcast.

Sep 25, 2020 This Week in Cardiology Podcast Sep 25, 2020

COVID sport participation guidelines, beta-blockers after MI, and low-dose DOAC therapy in AF are the topics covered by John Mandrola, MD, in this week’s podcast.

Sep 18, 2020 This Week in Cardiology Podcast Sep 18, 2020

COVID, CMR after COVID, ISCHEMIA trial substudy, valvular heart disease and AF are the topics John Mandrola, MD, discusses in this week’s podcast.

Sep 11, 2020 This Week in Cardiology Podcast Sep 11, 2020

COVID, icosapent ethyl, sudden death, and antiplatelet choices in the elderly are topics John Mandrola, MD, discusses in this week’s podcast.

Sep 4, 2020 This Week in Cardiology Podcast Sep 04, 2020

COVID, trust in the FDA, and ESC Recap: Part 1 are the topics John Mandrola, MD, covers in this week’s podcast.

Aug 28, 2020 This Week in Cardiology Podcast Aug 28, 2020

COVID and the heart, convalescent plasma, PCI in the VA system, and the upcoming ESC meeting are discussed by John Mandrola, MD, in this week’s podcast.

Aug 21, 2020 This Week in Cardiology Podcast Aug 21, 2020

COVID, diversity, clinical research, the S-ICD, and ECGs are the topics discussed by John Mandrola, MD in this week’s podcast.

Aug 14, 2020 This Week in Cardiology Podcast Aug 14, 2020

COVID, obesity, heart failure, Impella, and fitness are the topics John Mandrola, MD, discusses in this week’s podcast.

Jul 31, 2020 This Week in Cardiology Podcast Jul 31, 2020

COVID, cardiac effects of COVID, AF ablation safety, and SGLT2i are the topics discussed by Dr John Mandrola in this week’s podcast.

Jul 24, 2020 This Week in Cardiology Podcast Jul 24, 2020

COVID vaccines, T-cells, ICDs, Watchman, and two features are the topics John Mandrola, MD, discusses in this week’s podcast.

Jul 17, 2020 This Week in Cardiology Podcast Jul 17, 2020

COVID, the EXCEL trial, AF ablation, and pacemaker techniques are the topics discussed by John Mandrola, MD in this week’s podcast.

Jul 10, 2020 This Week in Cardiology Podcast Jul 10, 2020

COVID, sacubitril/valsartan, left atrial appendage occlusion, and statins are the topics Dr John Mandrola discusses in this week’s podcast.

June 26, 2020 This Week in Cardiology Podcast Jun 26, 2020

COVID, science communication breakthrough, tricuspid valve disease, and AF ablation are the topics discussed by John Mandrola, MD, in this week’s podcast.

Jun 19, 2020 This Week in Cardiology Podcast Jun 19, 2020

COVID19, corticosteroids, CAC, SGLT2i, and vericiguat are the topics discussed by Dr. John Mandrola in this week’s podcast.

Jun 12, 2020 This Week in Cardiology Podcast Jun 12, 2020

ISCHEMIA, COVID-19 statistics, and racial justice are discussed by Dr John Mandrola in this week’s podcast.

Jun 5, 2020 This Week in Cardiology Podcast Jun 05, 2020

COVID19, protests, Impella, Excel, Bayesian statistics, and journal retractions are discussed by John Mandrola, MD, in this week’s podcast.

May 29, 2020 This Week in Cardiology Podcast May 29, 2020

COVID-19, nursing homes, evidence based medicine, hydroxychloroquine and VT, and remdesivir are the topics discussed by John Mandrola, MD, in this week’s podcast.

May 22, 2020 This Week in Cardiology Podcast May 22, 2020

COVID-19, medical education, collider bias, Watchman, and VT are the topics John Mandrola, MD, discusses in this week’s podcast.

May 15, 2020 This Week in Cardiology Podcast May 15, 2020

COVID-19 stats, anticoagulation in acute COVID-19 illness, ICD trials, and left bundle branch pacing are the topics discussed by John Mandrola, MD, in this week’s podcast.

May 8, 2020 This Week in Cardiology Podcast May 08, 2020

COVID-19, the angiotensin receptor blocker, TAVR, and acute stroke care are covered by John Mandrola, MD, in this week’s podcast.

May 1, 2020 This Week in Cardiology Podcast May 01, 2020

COVID-19, social distancing, ECG monitoring, thrombosis, and TAVR are discussed by John Mandrola, MD, in this week’s podcast.

Apr 24, 2020 This Week in Cardiology Podcast Apr 24, 2020

New epidemiologic studies, pitfalls of testing, and treatments for COVID-19 are the topics discussed by John Mandrola, MD in this week’s podcast.

Apr 17, 2020 This Week in Cardiology Podcast Apr 17, 2020

The COVID-19 crisis—epidemiology, viral therapeutics, pulmonary management, and coagulopathy—is the topic discussed by John Mandrola, MD in this week’s podcast.

Apr 10, 2020 This Week in Cardiology Podcast Apr 10, 2020

The COVID-19 crisis—epidemiology, ventilation protocols, telemedicine, and humanity in these dark days—are the topics discussed by John Mandrola, MD in this week’s podcast.

Apr 3, 2020 This Week in Cardiology Podcast Apr 03, 2020

The COVID19 crisis—heroes, viral spread, betrayals, and intolerance of ideas—are discussed by John Mandrola, MD in this week’s podcast.

Mar 27, 2020 This Week in Cardiology Podcast Mar 27, 2020

The COVID-19 crisis—ethics, hydroxychloroquine, and angiotensin drugs—are among the topics discussed by John Mandrola, MD in this week’s podcast.

March 20, 2020 This Week in Cardiology Podcast Mar 20, 2020

The newest developments in COVID-19 are discussed by John Mandrola, MD, in this week’s podcast.

Mar 13, 2020 This Week in Cardiology Podcast Mar 13, 2020

COVID-19 is the topic of this week’s podcast.

Mar 6, 2020 This Week in Cardiology Podcast Mar 06, 2020

COVID-19, left main coronary diseases, and cascades are the topics covered by Dr John Mandrola in this week’s podcast.

Feb 28, 2020 This Week in Cardiology Podcast Feb 28, 2020

Social media tension, bempedoic acid, hopeful news from CMS, and carotid interventions are the topics discussed by Dr John Mandrola in this week’s podcast.

Feb 21, 2020 This Week in Cardiology Podcast Feb 21, 2020

More fuel piled onto the EXCEL trial controversy, GI bleeds in AF, medical education, and revascularization procedures are covered by Dr John Mandrola in this week’s podcast.

Feb 14, 2020 This Week in Cardiology Feb 14, 2020

Cardiac stents, cardio-oncology, VT ablation, acute AF are the topics discussed by Dr John Mandrola in this week's podcast.

Feb 7, 2020 This Week in Cardiology Podcast Feb 07, 2020

The NEJM retraction, TAVR 5-year results, ICD selection, long QT reversals, and lung cancer screening are the topics discussed by John Mandrola, MD in this week's podcast.

Jan 24, 2020 This Week in Cardiology Podcast Jan 24, 2020

Executive physicals, coconut fat, leadless pacemakers, coils, and independent nurse practitioners and physician assistants are the topics discussed by Dr. John Mandrola in this week’s podcast.

Jan 17, 2020 This Week in Cardiology Podcast Jan 17, 2020

EXCEL, amyloid cardiomyopathy, drug prices, palliative care in cardiology, and gender bias are the topics covered by Dr John Mandrola in this week’s podcast.

Jan 10, 2020 This Week in Cardiology Podcast Jan 10, 2020

The Excel trial, peripartum cardiomyopathy, marathoning, hot-spotting, and leadership in innovation are the topics discussed by Dr. John Mandrola in this week’s podcast.

Jan 3, 2020 This Week in Cardiology Podcast Jan 03, 2020

The EXCEL debate, the NOBLE trial, alcohol and AF, cardiac devices, and hospital consolidation are the topics covered by John Mandrola, MD, in this week’s podcast.

Dec 20, 2019 This Week in Cardiology Dec 20, 2019

A risk score for device infection, conflicts of interest, the Fragility Index, rhythm vs rate control for AF in HFpEF, and year-end highlights are discussed by John Mandrola, MD, in this week's podcast.

Dec 13, 2019 This Week in Cardiology Dec 13, 2019

The EXCEL trial controversy, and Dr John Mandrola's experience with vernakalant at FDA are the topics covered in this week's podcast.

Dec 6, 2019 This Week in Cardiology Podcast Dec 05, 2019

Vernakalent, CV death in cancer patients, dapagliflozin, and sacubitril/valsartan are the topics Dr. John Mandrola discusses in this week’s podcast.

Nov 22, 2019 This Week in Cardiology Podcast Nov 22, 2019

Highlights from the 2019 AHA meeting are analyzed by Dr John Mandrola in this week’s podcast.

Nov 15, 2019 This Week in Cardiology Podcast Nov 15, 2019

Interruption of oral anticoagulation, marijuana and stroke, ORBITA substudy, ISCHEMIA medical therapy targets, and more on AHA are the topics discussed by Dr. John Mandrola in this week’s podcast.

Nov 8, 2019 This Week in Cardiology Podcast Nov 08, 2019

Words that harm, statins, thyroid replacement, and the ISCHEMIA trial are the topics discussed by Dr John Mandrola in this week’s podcast.

Nov 1, 2019 This Week in Cardiology Podcast Nov 01, 2019

Mortality after AF ablation, cardiac rehab programs, hypertrophic cardiomyopathy, and clinician wellness are the topics Dr. John Mandrola discusses in this week’s podcast.

Oct 25, 2019 This Week in Cardiology Podcast Oct 25, 2019

AF after TAVR, opioids after cardiac devices, hypertension in black adults, and post-cardiac surgery AF are the topics Dr John Mandrola discusses in this week’s podcast.

Oct 18, 2019 This Week in Cardiology Podcast Oct 18, 2019

The Nobel Prize, more on the EXCEL trial, the costs of cardiac tests, familial hypercholesterolemia, and burnout are the topics discussed by Dr John Mandrola in this week’s podcast.

Oct 11 2019 This Week in Cardiology Oct 11, 2019

Left main PCI vs CABG trials and TAVR vs SAVR—in this week’s podcast, Dr John Mandrola takes a deeper dive.

Sep 27, 2019 This Week in Cardiology Podcast Sep 27, 2019

Social effects of medicine, SGLT2 inhibitors, CIED infections, equity in cardiology, and post-PCI anti-thrombotic therapy are the topics discussed by Dr John Mandrola in this week’s podcast.

Sep 20, 2019 This Week in Cardiology Podcast Sep 20, 2019

The polypill, dapagliflozin, TAVR, and video games are discussed by John Mandrola, MD, in this week’s podcast.

Sep 13, 2019 This Week in Cardiology Podcast Sep 13, 2019

More from ESC: Antiplatelets and NOACs, blood glucose control, high sensitivity troponin tests, and ICD trials are all covered by John Mandrola, MD, in this week’s podcast.

Sep 6, 2019 This Week in Cardiology Podcast Sep 06, 2019

Six major trials from the ESC meeting in Paris are reviewed by John Mandrola, MD, in this week’s podcast.

Aug 30, 2019 This Week in Cardiology Podcast Aug 30, 2019

Digital health, a new LDL-c lowering drug, PCSK9i outcomes in higher risk patients, and an ESC preview are discussed by John Mandrola in this week’s podcast.

Aug 23, 2019 This Week in Cardiology Podcast Aug 23, 2019

TAVR, baroreflex activation for heart failure, dapagliflozin for HF, and myocardial viability are the topics discussed by John Mandrola in this week’s podcast.

Aug 16, 2019 This Week in Cardiology Podcast Aug 16, 2019

AI for AF detection, syncope and PE, thoracentesis, fish oil, and why doctors should organize are the topics covered by John Mandrola in this week’s podcast.

Aug 2, 2019 This Week in Cardiology Podcast Aug 02, 2019

Digoxin, acupuncture and angina, heart failure with preserved ejection fraction, bariatric surgery, and cardiac device complications are the topics John Mandrola covers in this week's podcast.

Jul 26, 2019 This Week in Cardiology Podcast Jul 26, 2019

CRT in patients with non-LBBB, ezetimibe, lifestyle diseases in the young, end of life care, and diabetes for the cardiologist are the topics John Mandrola, MD discusses in this week's podcast

Jul 19, 2019 This Week in Cardiology Podcast Jul 19, 2019

Deprescribing beta bockers, interrupting oral anticoagulants, sudden death, quality measures, and acute stroke care are the topics John Mandrola, MD discusses in this week’s podcast.

Jul 12, 2019 This Week in Cardiology Podcast Jul 14, 2019

High-sensitivity troponin assays, nursing education, negative risk markers, valve-in-valve TAVRs, and the use of AI in medical practice are covered in this week’s podcast.

Jun 28, 2019 This Week in Cardiology Podcast Jun 28, 2019

Medical reversals, conflict of interest in the cardiac cath lab, cardiologist burnout, and changes in TAVR rules are discussed by John Mandrola, MD, in this week's podcast.

Jun 21, 2019 This Week in Cardiology Podcast Jun 21, 2019

FDA hearings on paclitaxel devices in PAD, health news spin, myocarditis, difficult conversations, and TAVR in patients with end stage renal disease (ESRD) are discussed in this week’s podcast.

Jun 14, 2019 This Week in Cardiology Podcast Jun 14, 2019

Vitamin D, ICD in patients on dialysis, aspirin, type 2 diabetes, and paclitaxel in PAD are the topics covered by John Mandrola in this week’s podcast.

Jun 7, 2019 This Week in Cardiology Podcast Jun 07, 2019

Complications of PCI, health hubs, AV block after TAVR, VTE prevention, and rivaroxaban use in patients with heart failure are the topics discussed by Dr John Mandrola in this week's podcast.

May 31, 2019 This Week in Cardiology Podcast May 31, 2019

Tricuspid valve repair, aortic stenosis, His-bundle pacing, deprescribing loop diuretics, and ‘leakage’ are covered in this week’s podcast.

May 24, 2019 This Week in Cardiology Podcast May 24, 2019

Aspirin and ICH, late tPA for stroke, public reporting of outcomes, Impella, grapefruit juice and QT interval, and ICDs for primary prevention are discussed in this week’s podcast.

May 17, 2019 This Week in Cardiology Podcast May 17, 2019

Renal and AF ablation in combination, infection risk of devices, neuromodulation of AF, pulsed field ablation and stroke of unknown source are covered in a HRS-heavy podcast.

May 10, 2019 This Week in Cardiology Podcast May 10, 2019

Spin in the cardiovascular literature, palliative care for cardiac patients, tPA for acute stroke, and whether institutional volume affects AF ablation complications are the topics discussed this week.

May 3, 2019 This Week in Cardiology Podcast May 03, 2019

Bike commuting and obesity, CMR for NSTEMI, Niacin in secondary prevention, cardiologists’ pay, and end-of-life conversations are in this week’s podcast.

Apr 19, 2019 This Week in Cardiology Podcast Apr 19, 2019

Anticoagulation for embolic stroke of unknown origin, added-sugar labels, AF-patient knowledge, LDL-C and hemorrhagic stroke, and genetic signals in cancer-care cardiomyopathy are discussed this week.

Apr 12, 2019 This Week in Cardiology Podcast Apr 12, 2019

Super-saturated oxygen in STEMI, Medicaid expansion and CV mortality, pacemakers in patients with HFpEF, HF readmissions, and exercise vs diet for weight loss are discussed in this week’s podcast.

Apr 5, 2019 This Week in Cardiology Podcast Apr 05, 2019

ARB recalls, bystander compression-only CPR, renal denervation for hypertension, LDL cholesterol targets, and pre-op frailty are the topics discussed in this week’s podcast.

Mar 29, 2019 This Week in Cardiology Podcast Mar 29, 2019

Catheter ablation for atrial fibrillation, eggs, booze, and anti-thrombotic agents for double vs triple therapy in patients with ACS and AF are discussed in this week’s podcast.

Mar 22, 2019 This Week in Cardiology Podcast Mar 22, 2019

From ACC.19 and EHRA: The Apple Heart study, TAVR for low-surgical-risk AS, preventing cardiac device infections, COACT, VF arrest, and AF cardioversion are discussed in this week's podcast.

Mar 15, 2019 This Week in Cardiology Podcast Mar 15, 2019

Obesity paradox studies and collider bias, the ISCHEMIA trial baseline findings, expanded indications for the MIitraClip, and an ACC preview are covered in this week’s podcast.

Mar 8, 2019 This Week in Cardiology Podcast Mar 08, 2019

N of 1 hypertension trials, heart failure readmissions and HRRP, insulin, CTA vs functional stress testing, and the ongoing paclitaxel PAD controversy are discussed in this week’s podcast.

Mar 1, 2019 This Week in Cardiology Podcast Mar 01, 2019

Lead extraction, AF triggers, cognitive decline and CV risk factors, low-value care, and secondary prevention in the real world are discussed in this week’s podcast.

Feb 22, 2019 This Week in Cardiology Podcast Feb 22, 2019

Factor Xa reversal agent Andexa, PTSD, gender transition hormones and CVD, primary care physician shortage, and a commentary from a young interventional cardiologist are discussed this week.

Feb 15, 2019 This Week in Cardiology Podcast Feb 15, 2019

The cost of cardiac care, statin adherence and mortality, syncope, ultra-processed food, and heart failure survival are discussed in this week's podcast.

Feb 8, 2019 This Week in Cardiology Podcast Feb 08, 2019

Statins in the elderly, donor hearts and the opioid crisis, Impella, coronary calcium in exercisers, and the plateau in heart disease deaths are discussed in this week’s podcast.

Feb 1, 2019 This Week in Cardiology Podcast Feb 01, 2019

New guidelines for atrial fibrillation, PFO closure for stroke prevention, fried chicken, skipping breakfast and e-cigarettes are discussed in this week’s podcast.

Jan 25, 2019 This Week in Cardiology Podcast Jan 25, 2019

Aspirin for primary prevention, alcohol and Afib, high-sensitivity troponin, and women in interventional cardiology are discussed in this week’s podcast.

Jan 18, 2019 This Week in Cardiology Podcast Jan 18, 2019

Burnout, aspiration thrombectomy, fish intake, insurance coverage, and the gout drug febuxostat are discussed in this week’s podcast.

Jan 11, 2019 This Week in Cardiology Podcast Jan 11, 2019

Appropriate use criteria for imaging, HRRP efficacy, medical marijuana, radiation exposure in the cath lab, and hormone therapy are the topics discussed this week’s podcast.

Jan 4, 2019 This Week in Cardiology Podcast Jan 04, 2019

The cost of treating high blood pressure, heart-failure readmission policies, abdominal fat, low flow/low gradient aortic stenosis and hypertensive disorders of pregnancy are discussed this week.

Dec 21, 2018 This Week in Cardiology Podcast Dec 21, 2018

Dr John Mandrola discusses upcoding for PCI, hypertension, a pacing lead issue, a PAD trial discovery, and an FDA warning on fluoroquinolones in this week’s podcast.

Dec 14, 2018 This Week in Cardiology Podcast Dec 14, 2018

Carotid stents, more stem-cell retractions, AHA statement on statin safety, flu vaccine rules, medication errors, veterans care, and wasteful NIH research on golfing are discussed in this week’s podcast.

Dec 7, 2018 This Week in Cardiology Podcast Dec 07, 2018

Measures of hospital quality, statin under- or over-use, Botox for AF, smoking cessation and translating trial evidence to clinical practice are discussed in this week’s podcast.

Nov 30, 2018 This Week in Cardiology Podcast Nov 30, 2018

TAVR vs surgery for high-risk aortic stenosis, conflicts of interest for physicians and societies, spin in the CV literature, and low-carb diets are discussed in this week’s podcast.

Nov 16, 2018 This Week in Cardiology Podcast Nov 16, 2018

The top 5 studies from the recent American Heart Association meeting and the new cholesterol guidelines are discussed in this week’s podcast.

Nov 9, 2018 This Week in Cardiology Podcast Nov 09, 2018

ODYSSEY PCSK9 inhibitor trial in print, new bradycardia guidelines, echocardiography, and an AHA preview are the topics discussed in this week’s podcast.

Nov 2, 2018 This Week in Cardiology Podcast Nov 02, 2018

CV outcomes in patients with type 2 diabetes, canagliflozin, cardiorespiratory fitness, the value of randomized trials, and the most important paper of 2018 are reviewed in this week’s podcast.

Oct 26, 2018 This Week in Cardiology Podcast Oct 26, 2018

Oxygen supplementation, PCSK9 inhibitor pricing, rapid troponin testing, cardio-oncology and joint commission accreditation are discussed in this week’s podcast.

Oct 19, 2018 This Week in Cardiology Podcast Oct 19, 2018

Low-dose rivaroxaban for CAD/PAD, hypertension management in the community, research misconduct, cyber-security in cardiac devices, and bariatric surgery are discussed in this week’s podcast.

Oct 12, 2018 This Week in Cardiology Podcast Oct 12, 2018

Timing of aortic valve replacement, rivaroxaban failure post TAVR, statins beyond CVD, conflicts of interest, and post-stent antithrombotic management are discussed in this week’s podcast.

Sep 28, 2018 This Week in Cardiology Podcast Sep 28, 2018

The COAPT MitraClip trial, high dose omega-3 fatty acids, the VEST trial in print, renal denervation for resistant hypertension, and competing coronary stents are discussed in this TCT-heavy podcast.

Sep 21, 2018 This Week in Cardiology Podcast Sep 21, 2018

ASA, polypharmacy, statins and obesity treatments are the topics discussed by Dr John Mandrola in this week’s podcast

Sep 14, 2018 This Week in Cardiology Podcast Sep 14, 2018

The Apple Watch EKG, ablate/pace strategies, chronic total occlusion-PCI, assisted reproduction strategies and CV health, and remembering Ron Victor, MD are the topics for this week’s podcast.

Sep 7, 2018 This Week in Cardiology Sep 07, 2018

High sensitivity troponin, radial access (a good news story!), stroke care, rivaroxaban in CAD and PAD, and the components of a healthy diet are discussed in this week’s podcast.

Aug 31, 2018 This Week in Cardiology Aug 31, 2018

Aug 24, 2018 This Week in Cardiology Podcast Aug 24, 2018

The salt wars, drug costs and vaule, Takotsubo syndrome, carb intake, and the upcoming European Society of Cardiology congress are discussed in this week’s podcast

Aug 17, 2018 This Week in Cardiology Aug 17, 2018

Screening athletes, AF ablation complications, physician gender and MI mortality, the rise of chronic kidney disease, and the rosuvastatin lawsuit are discussed in this week's podcast.

Aug 10, 2018 This Week in Cardiology Aug 10, 2018

AF screening, atrial flutter, palliative care in heart failure, and LDL-C lowering are discussed in this week's podcast

Aug 3, 2018 This Week in Cardiology Aug 03, 2018

Aspirin dosing, a potential new drug for SVT, apixaban in patients with ESRD, TAVR, and saunas, are discussed in this week's podcast

Jul 27, 2018 This Week in Cardiology Jul 27, 2018

Leadless pacing, AF detection, coronary calcium, BP control and omega-3 fatty acids are discussed in this week's podcast.

Jul 13, 2018 This Week in Cardiology Jul 13, 2018

Questionable ICD use, ambulatory blood pressure monitoring, multivitamins and cardiovascular health, and end-of-life care are discussed in this week's podcast

Jun 29, 2018 This Week in Cardiology Podcast Jun 29, 2018

Dr John Mandrola discusses controversy over the ISCHEMIA trial, AAA screening, PCSK9i in diabetes, cardiac arrest and Twitter in this week’s podcast

Jun 22, 2018 This Week in Cardiology Podcast Jun 22, 2018

PREDIMED (again), malpractice concerns in CAD testing, alcohol, stroke care in the elderly, and genetic testing are the topics discussed by Dr John Mandrola in this week’s podcast

Jun 15, 2018 This Week in Cardiology Jun 15, 2018

Nutrition education for docs, PREDIMED retraction, recommendations for ECG screening of healthy adults, and MOC studies are discussed in this week's podcast.

Jun 8, 2018 This Week in Cardiology Jun 08, 2018

Better equations for CV risk prediction, a drug for bradycardia, illicit drugs and MI in the young, EHR woes, and vitamins for CV risk reduction are discussed in this week's podcast.

Jun 01, 2018 This Week in Cardiology Jun 01, 2018

Surgical left atrial appendage occlusion, renal denervation, a substudy of ORBITA, FFR and hypertension guidelines are discussed in this week's podcast.

May 18, 2018 This Week in Cardiology May 18, 2018

Device-related thrombosis with Watchman left atrial appendage closure, debulking atrial fibrillation after ablation, rivaroxaban for stroke prevention, alteplase, and Lp(a) are discussed this week.

May 11, 2018 This Week in Cardiology May 11, 2018

The CABANA trial on catheter ablation in patients with atrial fibrillation is discussed in this week’s podcast recorded at the Heart Rhythm Scientific Sessions.

May 4, 2018 This Week in Cardiology May 04, 2018

AHA rescinds sections of the stroke guidelines, thrombectomy for pulmonary embolism, Mitra-clip, nuts and AF, and blood pressure measurements are discussed in this week's podcast.

Apr 27, 2018 This Week in Cardiology Apr 27, 2018

Lipid-lowering and baseline LDL-C, the CV safety of NSAIDs, 'metabolically healthy' obesity, PCI for chronic total occlusions, and wearable tech are discussed in this week's podcast.

Apr 20, 2018 This Week in Cardiology Apr 20, 2018

Ambulatory BP measurements, advanced practice providers, medical marijuana for sleep apnea, Barbara Bush's comfort care, and apixaban for cardioversion are the topics discussed in this week's podcast.

Apr 13, 2018 This Week in Cardiology Apr 13, 2018

Atrial fibrillation after cardiac surgery, long QT syndrome, exercise for CV prevention, a new risk factor for mothers, and coronary obstruction post TAVR are discussed in this week's podcast.

Apr 6, 2018 This Week in Cardiology Apr 06, 2018

Beta-blockers in diabetes, ACE inhibitors vs ARBs, cardiac implantable electronic device infections, alcohol and AF, and strengthening the p value threshold are discussed in this week's podcast.

Mar 30, 2018 This Week in Cardiology Mar 30, 2018

Dr. John Mandrola discusses heart failure care, methamphetamine, AF ablation, lead extraction, and myocardial injury after noncardiac surgery in this week's podcast.

Mar 23, 2018 This Week in Cardiology Mar 23, 2018

His-bundle pacing, Factor Xa reversal, heart failure quality measures, predicting prognosis after cardiac arrest, and myocarditis after cancer immunotherapy are discussed in this week's podcast.

March 16, 2018 This Week in Cardiology Mar 16, 2018

ODYSSEY, VEST, mSTOPS, CANTOS, and the Black barbershop blood pressure study are among the presentations from the 2018 American College of Cardiology meeting reviewed in this week's podcast.

Mar 9, 2018 This Week in Cardiology Mar 09, 2018

Obesity in young people, type-2 diabetes, the risks of varicose veins, on-pump vs off-pump coronary artery bypass surgery and an ACC preview are the topics discussed in this week's podcast.

March 2, 2018 This Week in Cardiology Mar 02, 2018

Vegetarian vs Mediterranean diets, a clarithromycin alert, a new stent, best choice of IV fluid, and early work in prevention Type I diabetes are discussed in this week's podcast.

Feb 23, 2018 This Week in Cardiology Feb 23, 2018

Atrial fibrillation after cardiac surgery, radial vs ulnar cath access, aspirin for heart failure, VTE prophylaxis and low-fat vs high-carb diets are discussed in this week's podcast.

Feb 16, 2018 This Week in Cardiology Feb 16, 2018

ICD use in patients with CKD, PFO and peri-operative stroke, LV assist devices, guideline-directed medical therapy after revascularization, and upcoming trials in 2018 are discussed in this week's podcast.

Feb 9, 2018 This Week in Cardiology Feb 09, 2018

Genetic risk scores and early onset CAD, ECGs in athletes, the ripple effect of weight loss, troponin in sepsis, and fish oil for CVD prevention are the topics discussed in this week's podcast.

Feb 02, 2018 This Week in Cardiology Feb 02, 2018

Loperamide abuse, heart failure quality measures, and the CASTLE-AF ablation study are discussed in this week's podcast.

Jan 26, 2018 This Week in Cardiology Jan 26, 2018

Surgical left atrial appendage closure, the effects of smoking and influenza on CV risk, acute stroke care, and why cardiologists are an unhappy bunch are discussed by Dr Mandrola this week.

Jan 19, 2018 This Week in Cardiology Jan 19, 2018

MRI in patients with cardiac devices, bariatric surgery, statins, the LifeVest wearable defibrillator, and spontaneous coronary dissection are the topics discussed in this week's podcast.

Jan 12, 2018 This Week in Cardiology Jan 12, 2018

Exercise effects on left ventricular compliance, CT in stable angina, MRI in patients with cardiac devices, a win for pharma, and ECG screening in adults are discussed in this week's podcast.

Dec 15 Cardiology News Dec 15, 2017

Noninvasive VT ablation, Riata leads, NOAC/DOAC therapies, HDL-C and infection risk, and fibrosis in triathletes are discussed in this week's podcast.

Dec 8 Cardiology News Dec 08, 2017

Mobile ECGs, PFO closure for migraine, AF care, lytic and mechanical removal of VTE and the PSCK9 inhibitor evolocumab are discussed in this week's podcast.

Dec 1 Cardiology News Dec 01, 2017

Sports preparticipation screening, cell therapy in PAD, exercise, supplements, and US healthcare policy are reviewed in this week’s podcast.

Nov 17 Cardiology News Nov 17, 2017

New hypertension guidelines, BP measurement, DOACs during device surgery, a CANTOS substudy, and conflicting data on the heart-failure readmissions reduction program are discussed this week.

Nov 10 Cardiology News Nov 10, 2017

Dr John Mandrola discusses PCI in stable CAD, MR, exercise, AHA preview, and celebrities at medical meetings in this week's podcast.

Nov 3 Cardiology News Nov 03, 2017

The ORBITA sham-control PCI study, Watchman, revascularization in cardiogenic shock, Absorb BVS, quality-of-life outcomes after PCI or bypass, and chronic total occlusion PCI are discussed in this week's podcast.

Oct 27 Cardiology News Oct 27, 2017

Statins tied to diabetes risk and reduced bacterial infections, a novel use for hs-troponin, mitral-regurgitation management, and His-bundle pacing are reviewed in this week's podcast.

Oct 20 Cardiology News Oct 20, 2017

Secondary AF, Heart failure statistics, DOAC bleeding rates, uncontrolled hypertension and stroke risk factors are discussed by John Mandrola in this week's podcast.

Oct 13 Cardiology News Oct 13, 2017

Noninvasive tests for chest pain evaluation, the obesity epidemic, the costs of cardiac device recalls, and DOAC-drug interactions are reviewed in this week's podcast.

Oct 6 Cardiology News Oct 06, 2017

Stopping aspirin, TAVR durability, meditation, triathlon risk, and BP control in low-income patients are discussed by Dr Mandrola in this week's podcast.

Sep 29 Cardiology News Sep 29, 2017

Oxygen therapy in stroke, physical activity, hospital rankings, MRI labeling of cardiac devices, and PFO closure are discussed in this week's podcast.

Sep 22 Cardiology News Sep 22, 2017

PCSK9 drugs and diabetes, allegations against St Jude Medical, trends in carotid interventions, food as medicine, and death with dignity are discussed by Dr John Mandrola in this week's podcast.

Sep 15 Cardiology News Sep 15, 2017

PFO closure for recurrent stroke prevention, hormone replacement in women, DAPT, obesity, and fentanyl are discussed in this week's podcast.

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