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    Health & Fitness

    The Poison Lab

    Dive into the captivating world of poisons with The Poison Lab! Hosted by Clinical Toxicologist Ryan Feldman (@EMPoisonPharmD), who has over a decade of managing poisoning and drug overdose via poison centers and in the emergency department. Also occasional co-hosted by his robo cohost Toxo! (@LabPoison). This show unpacks the fascinating history, cutting-edge science, and life-saving medical management of toxins from around the globe. From stories of those impacted to expert insights from pioneers in poisoning treatment, each episode brings you closer to understanding the poisons that lurk in plain sight. Explore episodes, med videos, games, and more at thepoisonlab.com—every poison has a story to tell!

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    Copyright: © thepoisonlab

    • Apple Podcasts
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    Latest Episodes:
    Toxicologists vs the Internet (#5) With Guest Dr Howard Greller MD (Sirius XM Doctor Radio Emergency Medicine Show, Dantastic Mr Tox & Howard, Tox & Hound) Mar 02, 2022
    Show notes

    Dr. Howard Greller, MD (Sirius XM Doctor Radio Emergency Medicine Show, Dantastic Mr Tox & Howard, Tox & Hound) joins the show. A FANTASTIC episode complete with toxic sleuthing of fatal poisoning cases and answering questions from reddit.com/r/askdrugs.

    Music from Pixabay

    • Additional information on toxins from fatal poisoning cases
    • Toxin 1
    • Toxin 2
    • Toxin 3
    • Toxin 4
    • Popper article referenced by Dr. Greller

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    Where is Episode 13 ? Bonus Episodes AND Next Episode Guest Dr. Howard Greller MD (Sirius XM Doctor Radio Emergency Medicine Show, Dantastic Mr Tox & Howard, Tox & Hound), Feb 02, 2022
    Show notes

    No episode today. Head here for the live radio show!

    Join us next show for Dr. Howard Greller of Sirius XM Doctor Radio, Dantastic Mr Tox & Howard, and Tox & Hound

    Find the article about the poison lab here

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    Lethal Buttock Injection (And Other Toxicities of Illegal Cosmetic Body Fillers) Dec 08, 2021
    Show notes

    In this episode Ryan and Toxo dissect the fascinating underbelly of illegal cosmetic procedures and breakdown the toxicities that arise from them.

    Intro

    • Case report of hemolysis after sodium deoxycholate injection
    • History

    Epidemiology

    • ASPS stats
    • Florida Unlicensed Activity Unit
    • Cost of surgeon fee for buttock implant 2018

    Recent new stories

    • Botox and Bubbles grifter
    • Quick bio on cases mentioned in show

    Common injection practices

    • Feminizing body contouring (pumping parties)
    • Synthol muscles
    • Capsule face cosmetics

    Toxicity

    • Infection
    • Self explanatory

    Filler embolism

    • Review 1, Review 2, Review 3
    • Filler lodges in pulmonary vasculature->clotting, bleeding, inflammation
    • 95% occur within 72 hours
    • Primarily respiratory symptoms (cough/hypoxemia)
    • Chest x ray ground glass opacity
    • Treat with supportive care (oxygen all the way through ECMO) +/- steroids
    • Filler Blindness
    • CRAO from body filler
    • No effective treatment (exception, can use hyaluronidase if filler is hyaluronic acid)

    Granuloma

    • Inflammatory nodules from prolonged filler exposure
    • May occur months to year after injection
    • Illegal cosmetic= frequently lipogranuloma due to oil being present in many illegal cosmetic
    • Granulomatous hypercalcemia
    • Excess calcitriol production from ganuloma causes hyperCA
    • Can be extremely delayed (up to 28 years)
    • Recurrence up to 45%
    • Treat with standard therapies (fluid, bisphosphonate) + steroids and/or ketoconazole to turn down granuloma CYP27B1 calcitriol production

    Case from the show

    • Some details changed for educational purposes

    Music in this episode from pixabay.com

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    A Mysterious Case of Hypercalcemia and Subdermal Nodules in a Transgender Patient (Episode #12 Mystery Case) Oct 06, 2021
    Show notes

    Send in your guesses to toxtalk1@gmail.com

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    Toxicologists vs the Internet (#4) With Guest Dr Andrew Farkas MD Oct 06, 2021
    Show notes

    In this episode of toxicologist vs internet guest Dr. Andrew Farkas, MD joins the show. This a great episode that covers everything from the drugs you would need in the apocalypse to what to worry about if your cats are dying. Complete with toxic sleuthing of fatal poisoning cases and answering questions from reddit.com/r/askdrugs.

    • Research from Dr Farkas
    • Additional information on toxins from Fatal poisoning cases
    • Toxin 1
    • Toxin 2
    • Toxin 3
    • Toxin 4
    • "Toxicologist vs the internet" segment
    • Cocaethylene review
    • Benzodiazepine urine drug screening - Blog post

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    You Left Your Bladder in The K-Hole? Aug 04, 2021
    Show notes

    In this episode Ryan and Toxo take a closer look at ketamine induced irreversible bladder damage.

    History

    • Discovery of Ketamine
    • Melamine outbreaks

    Clinical Effects

    • Index cases
    • Survey of Ketamine use prior to symptoms

    Mechanism/Treatment

    • Mechanism/Treatment systematic review
    • Rat models

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    A Mysterious Case of Bloody and Painful Urination in a 24 Year Old Male (Episode #10 Mystery Case) Jun 02, 2021
    Show notes

    What substance could cause these symptoms? Send your guesses to Toxtalk1@gmail.com to participate in episode 10!

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    Toxicologists vs the Internet (#3) With Guest Dr Justin Corcoran MD Jun 02, 2021
    Show notes

    In this episode of toxicologist vs the internet Ryan Is joined by special guest Dr. Justin Corcoran, MD an emergency medicine physician and medical toxicologist. They take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and challenge each others toxic sleuthing by presenting cases of poisoning and allowing the other to determine the toxin responsible.

    "Toxicologist vs the internet" segment

    • Everythingisosm.com (Blog post)
    • Biased Mu Receptor ligands
    • Oliceridine mouse studies
    • Opioid hearing loss (Blog post)
    • Opioid hearing loss review
    • Tox pupils (Blog post)
    • Why tramadol is awful (Blog post)

    Additional information on toxins from Fatal poisoning cases

    • Toxin 1
    • Toxin 2
    • Toxin 3
    • Toxin 4

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    Mini Episode: Setting The Record Straight on Delta 8 (THC) Apr 18, 2021
    Show notes

    Ryan and Toxo dive in to Delta 8 THC, a new (maybe?) legal drug sweeping the U.S.

    Delta-8 THC: Key Resources and Studies

    New York Times Coverage

    • Comprehensive article on Delta-8 THC, its growing popularity, and concerns: https://www.nytimes.com/2021/02/27/health/marijuana-hemp-delta-8-thc.html

    Studies of Delta-8 THC in Humans

    1. Systematic Review:
    2. Summarizes findings from a single key study on Delta-8 THC. https://pubmed.ncbi.nlm.nih.gov/29385080/
    3. Original Study (may not be accessible):
    4. Investigates Delta-8 THC effects in humans.
    5. https://www.karger.com/Article/Abstract/136375

    Testing Strategies for Delta-8 THC

    • HPLC-MS/MS Strategies:
    • Analytical methods for testing Delta-8 THC.
    • https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkaa184/6018445?redirectedFrom=fulltext

    Cannabinoid Receptor Binding

    • Mechanism of Action:
    • Study exploring how Delta-8 THC binds to cannabinoid receptors.
    • https://pubmed.ncbi.nlm.nih.gov/27398024/

    If you’re interested in learning more or exploring the impact of Delta-8 THC, these resources provide a great starting point. Thank you for listening!

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

    More Bitter than Sweet (Mad Honey and Grayanotoxin) Mar 31, 2021
    Show notes

    Case from the show

    • https://pubmed.ncbi.nlm.nih.gov/22163140/

    Mithradates

    • https://www.wemjournal.org/article/S1080-6032(11)00043-3/pdf

    Case series on mad honey effects

    • https://pubmed.ncbi.nlm.nih.gov/20575670/

    Blog post on sodium channel openers

    • https://emcrit.org/toxhound/ff-plant-sodium-channel-openers/

    A Morel Dilemma

    Support the show

    Review the show where ever your listening

    Get Messages from Toxo (Join the Newsletter!)

    Join as a supporting member

    • Ad free episodes
    • Bonus content and early access
    • Discounts and give aways on GOTA PICCEM Mushroom card game

    The GOTTA PICCEM Poisonous Mushroom Game!

    The Poisonus Fungus Amongus Children's Book!

    • Full book reading (6 minutes!)

    Tox trinkets (Rep the show at home!)

    Reach the show

    • Email: Toxtalk1@gmail.com

    More Show Resources

    • Ryan's Medical Games and Resources
    • Show Website

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