The Optispan Podcast with Matt Kaeberlein

Latest Episodes:

How He TRANSFORMED His Health by Taking Accountability. | 33 - Healthspan Journey #1 May 16, 2024

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Subscribe to our channel: https://www.youtube.com/@optispan The journey towards prioritizing one's healthspan can be a circuitous path full of triumphs, setbacks and lessons. Challenges arise and old habits rear their ugly heads. Unforeseen obstacles test our resolve. The road is rarely linear and often leads us to unexpected places. In this episode, Matt chats with former Microsoft Chief Technology Officer and one of our first Optispan Trailblazers Stuart McKee about Stuart's early forays into drugs, smoking, and alcohol consumption, how he stepped off the train to get his health (and life) in order, and how the healthcare system can shape our attitude to healthspan optimization, for better or for worse. Stuart shares his meticulous approach to finding the right primary care doctor, strategies for weight loss from an obese baseline, and experiences with clomid therapy. They also discuss the influence of mindset and external influence on our healthspan optimization trajectories. Stuart is currently a Strategic Advisor to the software company Armada, where he collaborates with the executive team to identify opportunities, innovative solutions, and market priorities to drive awareness and growth for the company. He also serves as a substitute teacher for Washington's Northshore School District. He was previously Chief Operating Officer at the artificial intelligence and spatial analytics company Hayden AI and Chief Executive Officer of Optispan Geroscience LLC, a precursor to Optispan as it exists today. Stuart spent 16 years at Microsoft. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

The Best Strategies for Living Longer RANKED: Longevity Tier List | 32 - HSM #7 May 14, 2024

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Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS | 31 - R-Files #5 May 09, 2024

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Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: The R-Files episode 1: https://youtu.be/czx_-DqnnrQ The R-Files episode 2: https://youtu.be/EgIy0ghrDmo The R-Files episode 3: https://youtu.be/jLV5nOenD-g The R-Files episode 4: https://youtu.be/6AjKOe-yZeM Matt Kaeberlein's ALLERGIC REACTION to Medication While on Rapamycin: https://youtu.be/6vIVj4SaBx4 Are DEXA scans ACCURATE? What YOU NEED to KNOW: https://youtu.be/SsDJZMlM1ko The Importance of Body Composition & Ways YOU can measure it: https://youtu.be/gM3aYTMsqNI The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attracted research interest for its ability to extend lifespan and delay age-related diseases in various model organisms, including yeast and mice. In our fifth episode of the R-Files, Matt shares insights from his recent course of off-label rapamycin use, which he started in January 2024 and plans to continue for at least the next month or two. He describes improvements in joint pain and body fat loss as well as an unexpected bacterial infection, and speculates about whether rapamycin may have contributed to any of these effects. He also discusses rapamycin's half-life in his blood, which is significantly lower than that reported in the published literature. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!

Reversing Biological Age: Have we finally found the answer?? | 30 - LTW #5 May 07, 2024

Show notes

Subscribe to our channel: https://www.youtube.com/@optispan Matt recently exchanged a lively correspondence about biological age with Harold Katcher, cofounder of a stealth biotechnology company and inventor of E5. E5 is a compound consisting of the purified exosome fraction of blood from young piglets—in other words, young pig blood. Harold recently co-published a paper suggesting that injecting this young pig blood into rats made rats younger on several biological aging measures, including inflammatory markers and epigenetic aging signatures. Indeed, Harold has injected E5 into his own right hand and presented differences in the appearance of his right and left hands on social media. Putting pig blood into other animals (and into ourselves!) to reverse biological age might seem like a crazy thing to do. But this idea actually stems from a methodology with a decades-long history called heterochronic parabiosis, an area of research that explores the effects of joining the circulatory systems of different-aged organisms. In this experimental technique, researchers surgically connect two animals, typically mice, of disparate ages so that they share a common bloodstream. This union leads the older and younger individuals to exchange not just blood cells but also signaling molecules, growth factors, and other circulating factors. Remarkably, when an older animal is paired with a younger counterpart, it often experiences improvements in various aspects of health and tissue function, while the younger partner may exhibit corresponding signs of accelerated aging. The mechanisms underlying these effects are complex, multifaceted, and very much still under investigation. In this episode, Matt takes a magnifying glass to E5: what we know about the compound, how it affects lifespan, and how its impact on lifespan stacks up with that of other longevity inventions such as caloric restriction and rapamycin. He discusses whether Harold's recent paper truly proves a reversal of biological age and where his findings fit into the larger body of literature in the field. He also gives us a window into the methodology of heterochronic parabiosis, what the primary data about life expectancy gains through this intervention show, and whether heterochronic parabiosis-inspired interventions such as E5 are realistic approaches to human lifespan extension. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/

AI vs Aging: Why Wormbot-AI is the secret weapon against disease | 29 - Mitchell Lee May 02, 2024

Show notes

Subscribe to our channel: https://www.youtube.com/@optispan Support the Longevity Million Molecule Challenge: https://orabiomedical.com/shop/ No single discipline or approach holds the key to making big strides in the longevity field. Human aging is incredibly complex, and we're going to need multiple shots on goal in our pursuit of human life- and healthspan extension. At the Optispan Podcast, we're always excited to learn about the various angles researchers and founders are taking to advance our understanding of longevity and get impactful therapeutics that will transform human health into the clinic. In this episode, Ora Biomedical CEO and cofounder Mitchell Lee gives us the lowdown on doing high-throughput drug discovery using a combination of worms, robotics, AI, and the general public. Matt and Mitchell talk about the company's ambitious goal to create the world's largest and most rigorous database of longevity interventions, and how a new robotics and AI data analysis platform is helping the company get there. They discuss the state of drug discovery in the longevity field, whether we can really believe any data we get from worms, the intervention that killed all their worms in one day, and more. Prior to cofounding Ora Biomedical, Mitchell spent his career focused on scientific research and mentorship, mentoring nearly 50 trainee researchers of all levels during his graduate and postdoctoral research periods. He was the founding Chair of the American Aging Association (AGE) trainee chapter, which offers early-career financial, career development, and networking benefits, and has served on the AGE Executive Committee and Board of Directors. Mitchell received a B.S. in biology, a B.A. in philosophy, and an M.S. in biology from Western Washington University. He completed his PhD in Experimental Pathology at the University of Washington School of Medicine, during which time he received a Howard Hughes Medical Institute (HHMI) Gilliam Fellowship for Advanced Study. Matt is a cofounder and Chair of the Board of Directors of Ora Biomedical. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

Aging Expert Explains How Healthcare got it ALL WRONG. | 28 - HSM #6 Apr 30, 2024

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Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: https://youtu.be/YhzgYaY7wto In April 2024, Matt delivered a presentation at a two-day congressional briefing on longevity science hosted at Washington, D.C.'s Mayflower Hotel by the Alliance for Longevity Initiatives (A4LI). Attendees included former Speaker of the House Newt Gingrich, Republican Congressman Gus Bilirakis, and Democratic Congressman Paul Tonko. We have decided to include Matt's presentation on our channel because we believe it delivers a valuable message. Healthcare has historically taken a piecemeal approach to diseases, addressing ailments in isolation. While this method has been successful at curing and sometimes even eradicating multiple diseases, it has its limitations. Aging is the single greatest risk factor for many of the chronic diseases we worry about in later life—think cancer, Alzheimer's disease, diabetes—and involves a complex interplay of molecular, cellular, and physiological changes that underlie a myriad of health conditions. There is a reason that your average 80-year-old has more health problems than your average 18-year-old. As our understanding of human biology deepens, it is becoming increasingly evident that we need to broaden our focus beyond individual diseases and incorporate the biology of aging into strategies for improving human health and resilience to disease. Achieving this paradigm shift towards addressing the fundamental processes of aging, which will require interdisciplinary collaboration between scientists, clinicians, policymakers, and the public, will give us the potential to mitigate multiple age-related diseases simultaneously. In this episode, Matt covers how we got here, the differences between 19th and 21st century medicine, and the importance of targeting the biological aging process to create transformative results in tackling healthcare challenges. He also discusses policy reforms that would be useful for the cause, including changes to FDA regulation, a rethinking of insurance reimbursement, and how he would reslice the federal funding pie. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

Inside this Non-profit's AMAZING Strategy to Fight Aging | 27 - Dylan Livingston Apr 25, 2024

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Subscribe to our channel: https://www.youtube.com/@optispan We talk a lot about the science of longevity and healthspan on the Optispan podcast—how DEXA scans work, what an optimal rapamycin dose might look like, how the intersection of optogenetics and mitochondria are helping us understand biological aging, what supplements one might consider taking and why. But the longevity field runs on way more than just science. It takes a village—a community of researchers, engineers, entrepreneurs, investors, regulators, and beyond who believe in the value of tackling the biology of aging as a crucial strategy for extending healthy lifespan—to create tangible results that benefit as many people as possible. At Optispan, we're eager to support and interact with the many levers that keep this machine going. One of these is the Alliance for Longevity Initiatives (A4LI), a nonprofit organization focused on catalyzing social and political action that will benefit the longevity field. In this episode, Matt chats with A4LI founder, president, and CEO Dylan Livingston about forming a bipartisan longevity science caucus, redirecting funding towards geroscience research, and engaging with policymakers to help them understand the importance of transitioning towards a proactive healthcare model. Dylan, who founded A4LI in 2021, served as a field organizer for President Joe Biden's 2020 presidential campaign. He also worked as a community organizer for Organizing Corps 2020, where he registered hundreds of Democratic voters in Pennsylvania for the 2020 presidential compaign. Dylan graduated from Haverford College with a B.S. in physics and a minor in economics. Matt joined the A4LI Board of Directors in 2024. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!

Guess his body fat percentage | #26 - Healthspan Medicine #5 Apr 23, 2024

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Subscribe to our channel: https://www.youtube.com/@optispan Related videos: The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI A DEXA (dual-energy X-ray absorptiometry) scan is an advanced imaging procedure for measuring bone density and composition. DEXA scans utilize two different energy levels of low-dose X-ray beams—one absorbed mostly by soft tissue, and the other absorbed mainly by bone—to differentiate between bone, fat, and lean tissue. In so doing, they provide noninvasive and detailed information about bone health, risk of osteoporosis or fractures, and body composition. While medical practioners typically perform DEXA scans on the lower spine and hips, they can also perform DEXA scans on the whole body for the purposes of early detection and intervention. In our multi-part DEXA series, we go deep into DEXA scans: what they measure, how to interpret them, and how to use information from your own DEXA scan for healthspan optimization. This week we're on Part II, where we analyze the DEXA scans of Matt and Optispan Lead Healthspan Analyst and certified personal trainer Nicholas Arapis. We unpack the nuances of the various metrics a DEXA scan measures, discuss potential noise in the results, and hear from Nick about what he would tell Matt to do if he was coaching Matt based on his DEXA scan results. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!

How "light-sensitive" proteins are being used to fuel scientific discovery | 25 - Brandon Berry Apr 18, 2024

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Doctors overlook how significantly this impacts your health. | 24 - HSM #4 Apr 16, 2024

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Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI We talk a lot about making a shift from reactive disease care—a 20th century healthcare mindset—to preventative and proactive health measures designed to optimize longevity and healthspan before disease sets in. Rather than waiting for chronic conditions to manifest and treating their symptoms post hoc, we encourage investing resources in preemptive care and empowering individuals to act as partners with healthcare providers in their own wellbeing. Preventative medicine can feel like a lot—cancer screenings, for example, are crucial for early detection and treatment, but can be logistically and emotionally daunting. But proactive healthcare doesn't always need to be complicated. In this episode, Matt goes through what he sees as low-hanging fruit in preventative medicine: simple steps that lend themselves to straightforward measurement, are easy to improve without invasive intervention or drastic lifestyle changes, and will pay dividends in increasing our overall health. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!

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