The Hunter Williams Podcast

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**The Hunter Williams Podcast**

Average health is a choice. And it’s the wrong one.

The Hunter Williams Podcast goes where mainstream medicine won’t — deep into the science of peptides, hormone optimization, metabolic health, and biohacking protocols that actually move the needle.

Every week, I sit down with elite researchers, doctors, and high-performers to cut through the noise and hand you biological leverage most people will never have access to.

This isn’t wellness. This is optimization.

Subscribe. Take control of your biology.

Latest Episodes:

SGLT2 Inhibitors and GLP-1s | The Holy Grail of Longevity Medicine Nov 07, 2025

Show notes

Email List: ⁠https://huntershealthhacks.beehiiv.com/⁠

Get My Book On Amazon: ⁠⁠https://a.co/d/avbaV48Download⁠⁠

The Peptide Cheat Sheet: ⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠

Download The Bioregulator Cheat Sheet: ⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠

1 On 1 Coaching Application: ⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠

Book A Call With Me: ⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠

Supplement Sources: ⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠

Amazon Storefront: ⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠

Socials:

Instagram: ⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠

Video Topic Request: ⁠⁠https://hunterwilliamsvideotopic.carrd.co/

In this episode, I dive deep into what I believe could be the most powerful synergy in the entire world of longevity and metabolic optimization — the combination of SGLT2 inhibitors (like Jardiance and Farxiga) with GLP-1 agonists (like Retatrutide, Tirzepatide, and Semaglutide).

These medications were originally created for diabetics, but what we’re learning now is that they may be rewriting the entire playbook on healthspan and lifespan extension. I break down the research showing how SGLT2 inhibitors not only lower blood glucose but also improve cardiovascular health, protect the kidneys, reduce inflammation, and even clear senescent cells — all while mimicking the effects of caloric restriction and fasting.

Then, I explain how pairing them with a GLP-1 creates a metabolic symphony unlike anything else we’ve ever seen. Together, they reduce insulin resistance, improve energy metabolism, and activate the same longevity pathways linked to caloric restriction, AMPK activation, and mitochondrial renewal.

If you care about living longer, staying leaner, and protecting every organ system in your body, this episode is a must-listen. I share what I’ve seen personally, what’s happening in clinical data, and why I believe the GLP-1 + SGLT2 combo could end up being one of the greatest discoveries in modern medicine for both health and performance.

How Thymosin Alpha 1 Supercharges Your Immune System Nov 04, 2025

Show notes

Email List: https://huntershealthhacks.beehiiv.com/

Get My Book On Amazon: ⁠https://a.co/d/avbaV48Download⁠

The Peptide Cheat Sheet: ⁠https://peptidecheatsheet.carrd.co/⁠

Download The Bioregulator Cheat Sheet: ⁠https://bioregulatorcheatsheet.carrd.co/⁠

1 On 1 Coaching Application: ⁠https://hunterwilliamscoaching.carrd.co/⁠

Book A Call With Me: ⁠https://hunterwilliamscall.carrd.co/⁠

Supplement Sources: ⁠https://hunterwilliamssupplements.carrd.co/⁠

Amazon Storefront: ⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠

Socials:

Instagram: ⁠https://www.instagram.com/hunterwilliamscoaching/⁠

Video Topic Request: ⁠https://hunterwilliamsvideotopic.carrd.co/

In this episode, I dive deep into one of my all-time favorite immune-support peptides — Thymosin Alpha 1 (TA-1).

As we head into cold and flu season, I wanted to do a full recap and update on why TA-1 is something I always keep in my own stack. It’s one of those foundational peptides that a lot of people overlook once they move on to “sexier” compounds, but the truth is — few things strengthen the immune system, fight inflammation, and restore balance like this one does.

I’ll walk you through:

What Thymosin Alpha 1 actually is and how it was discovered
How it works in the body to activate T-cells, natural killer cells, and the innate immune system
Its antiviral, anti-tumor, and anti-inflammatory effects backed by global clinical studies
Why it’s FDA-designated for certain cancers and used in over 35 countries for immune-related diseases
The real-world dosing strategies I use for immune maintenance, illness prevention, and recovery
How TA-1 synergizes with glutathione and other immune peptides
And why it’s an absolute must-have during stressful periods, travel, or any time your system feels run-down

I also share some of the newer data around TA-1’s role in cancer therapy, viral infections, and immune modulation — and why it continues to be one of the safest, most versatile peptides out there.

If you’re someone who wants to stay strong, resilient, and protected year-round without relying on the usual over-the-counter stuff, this episode is for you.

Peptide Replacement Therapy | The Future of Anti-Aging Medicine Oct 31, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

In this video, I dive deep into one of the most important concepts for the future of health optimization — Peptide Replacement Therapy (PRT). Just like we replace hormones as we age, it’s time to start replacing the endogenous peptides that naturally decline over time and are critical to maintaining energy, muscle, immunity, and longevity.

I walk through 14 naturally occurring peptides — like IGF-1, Thymosin Alpha 1, TB-500, KPV, MOTS-C, Humanin, SS-31, Glutathione, Epitalon, Kisspeptin, Oxytocin, GHK-Cu, and others — explaining what they do, how they decline with age, and how we can safely and effectively use peptide analogs to restore youthful balance and optimize the aging process.

If you’re already optimizing hormones, this is the next frontier in extending healthspan and performance — Peptide Replacement Therapy.

Pregnenolone Explained | When It Helps and When It Doesn’t Oct 28, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/

Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

In this video I break down pregnenolone for men on testosterone therapy and share when it helps, when it does nothing, and when it can backfire. We cover the steroidogenesis pathway so you can see where pregnenolone sits as the mother hormone. I explain how TRT suppresses LH and FSH and why that can lower testicular production of upstream steroids even if adrenal output is unchanged. I walk through pregnenolone’s role as a neurosteroid, how it converts to allopregnanolone, and why that often improves sleep quality, stress tolerance, and mood via GABA modulation. I also outline signs of low pregnenolone, summarize what the clinical literature suggests about cognition and anxiety, and give simple dosing guardrails I use personally and with clients. As always none of this is medical advice. Use it to have a smarter conversation with your clinician.

Microdosing Retatrutide vs Weekly Shots Oct 24, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

In this video, I break down one of the most misunderstood topics in the GLP-1 world — microdosing Retatrutide. There’s a lot of debate online about whether you should take Retatrutide once per week or split it into multiple smaller injections. Today, I’m going deep into the science, pharmacokinetics, and real-world experience behind both approaches so you can decide what’s right for you.

I cover how microdosing affects appetite, energy, side effects, and results, and why it might be the better approach for long-term metabolic optimization. You’ll also learn how this compares to traditional weekly dosing and why both methods can work — depending on your goals.

The Creatine Deep Dive | Real Science, Real Doses, Real Results Oct 21, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

Creatine is one of the simplest, most proven tools for strength, brain energy, and healthy aging. In this deep dive, I explain what creatine is, how it actually powers ATP, what the human data shows for performance, cognition, recovery, and longevity, how to dose it (with or without a loading phase), common myths and side effects, and why newer forms like “creGAAtine” might help you saturate muscle and brain with less water bloat. If you’ve asked me for my baseline supplement stack, this is where I start.

Glutathione Does It All | 2025 Update Video Oct 17, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

Injectable Glutathione: 2025 Update & Comprehensive GuideHey everyone, it's Hunter Williams here! In today's video, I bring you my 2025 update on glutathione, particularly injectable glutathione. I've used it for years and continue to be amazed by its benefits. This video expands on my previous content with newer clinical evidence and informed recommendations. We'll discuss its role in mitigating the effects of mitochondrial peptides, combating environmental stressors, and maintaining liver health. I'll delve into the bioavailability challenges of oral glutathione versus injectables, specific use cases like liver disease, male fertility, and even chemotherapy support. Plus, I'll share how to properly administer it, monitor its effects, and my personal insights on how it enhances energy, immune function, and overall well-being. Don't miss out on this detailed and informative guide—perfect for anyone into peptide research or looking to optimize their health! As always, check the links in the description, and don't forget to join my email list for updates. Thanks for your continuous support. Let's dive in!00:00 Introduction and Video Overview

02:39 What is Glutathione?

03:47 Bioavailability and Delivery Methods

06:06 Mechanisms of Action and Benefits

08:41 Clinical Applications and Case Studies

25:27 Dosing Guidelines and Best Practices

28:48 Conclusion and Final Thoughts

Oxytocin for....Fat Loss? Oct 14, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

Timestamps

00:00 Introduction and Video Overview00:14 Oxytocin and Its Connection to Fat Loss01:16 Scientific Data and Research on Oxytocin02:30 Mechanisms of Oxytocin in Fat Loss04:23 Oxytocin's Effects on Appetite and Metabolism05:29 Comparing Oxytocin with Other Weight Loss Aids10:37 Direct Actions of Oxytocin on Fat Cells11:59 Animal and Human Studies on Oxytocin19:26 Oxytocin Usage Protocols24:33 Potential Side Effects and Safety26:56 Conclusion and Final ThoughtsJoin me, Hunter Williams, as I delve into the fascinating connection between oxytocin—the 'love hormone'—and its surprising benefits for fat loss. Discover the scientific data and practical insights that show how this peptide hormone can enhance muscle preservation, improve metabolism, and reduce cravings for high-fat foods. Learn the optimal ways to use oxytocin, including dosing protocols and the synergy with diet and exercise. Don't forget to stay connected by joining my email list for updates on new videos and content. Let's dive in and explore how oxytocin can support your fitness and wellness journey!

October 2025 Q&A Video | Dosages, Stacks, and New Compounds! Oct 10, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

Timestamps

00:00 Introduction and Q&A Overview

01:39 First Question: CJC 1295 Dosage

02:20 Retatrutide with HCG Monotherapy

03:04 Peptides for Relaxation and PTSD

03:49 Peptides for Migraines

04:22 Combining GLP-1 and Tesamorelin

04:51 Workout Timing and Peptide Injections

06:08 Dealing with GLP-1 Fatigue

07:54 GLP-1 for Autoimmune Diseases

09:22 Peptides for Cold, Flu, and COVID-19

09:55 Peptides for Energy and Overall Health

10:39 Testing Peptides Separately vs. Blends

13:16 Metformin and Biomarker Testing

14:18 Body Recomposition and Peptides

15:07 Peptides for Tendinitis and Pain Management

16:18 Muscle Building Peptides

17:25 Metformin and Protein Synthesis

18:07 Thoughts on SARMs

19:16 Enclomiphene for Testosterone Production

20:25 Injectable Bioregulators

22:48 Peptides for Heart Health

23:30 Peptides for Lung Issues

25:40 Peptides for Hair Growth

30:12 Shipping Peptides in Summer Heat

31:08 Testosterone for Women

31:34 Bio Regulators for All Ages

31:53 Metformin and Jardiance: A Powerful Combo

32:22 Peptides for Histamine and Inflammation

32:54 Reconstituting Peptides: Tips and Tricks

34:31 Stacking Peptides: Safety and Recommendations

34:56 Comparing Metformin and ATX 304

36:02 Combining Peptides for Appetite and Weight Management

36:44 Titrating Off Tirzepatide

38:33 Understanding Blood Sugar and Insulin

40:37 Testosterone Therapy and Hair Loss

41:22 Peptides for Joint Pain and Recovery

42:19 Peptides for Lung Health

42:53 Peptides for Fat Loss in Athletes

43:42 Synthetic vs. Natural BioRegulators

44:21 Peptides and Gene Mutations

45:53 Testosterone Levels in Women

46:26 GLP Drugs for Weight Loss

47:02 Peptides for Perimenopausal Women

47:47 Stacking Tirzepatide and Retatrutide

48:29 Daily Timing of Peptides and Supplements

50:39 Combining Peptides in One Syringe

51:19 Peptides for Bladder Infections

51:54 Muscle Growth with Retatrutide

53:47 Peptides for Older Adults

54:40 Hormone Imbalance in Women Over 55

55:13 Peptides for Pets

56:43 Supplements with TRT

57:27 Evaluating Sermorelin

58:55 Dealing with Peptide-Induced Cramping

01:00:06 Final Thoughts and Appreciation

SS-31 Deep Dive | More Energy, Better Recovery, Stronger Cells Oct 07, 2025

Show notes

Get My Book On Amazon: https://a.co/d/avbaV48Download

The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/

Book A Call With Me: https://hunterwilliamscall.carrd.co/

Supplement Sources: https://hunterwilliamssupplements.carrd.co/

Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY

Socials:

Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/

Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/

00:00 Introduction and Video Overview

00:20 Personal Experience with SS 31

01:43 Scientific Basis and Human Trials

03:25 Mechanisms of SS 31

07:37 Clinical Applications and Benefits

14:46 Dosing Guidelines and Safety

21:21 Emerging Applications and Future Potential

26:51 Conclusion and Final Thoughts

In this comprehensive deep dive into SS-31, I'll be sharing my personal experience with this powerful mitochondrial peptide, its scientific mechanisms, clinical applications, dosing guidelines, and the outstanding benefits observed in various human trials.

Whether you're looking to enhance your energy levels, improve athletic performance, or support your cardiovascular and cognitive health, SS-31 offers promising solutions. Don't miss out on this essential biohacking tool!

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