The ASCO Post Podcast

Latest Episodes:

Veliparib Plus Carboplatin/Paclitaxel in BRCA-Mutated, HER2-Negative Advanced Breast Cancer Sep 11, 2020

Show notes

We’ll discuss the efficacy of a triplet combination therapy in BRCA-mutated, HER2-negative advanced breast cancer. Then, we’ll move on to a report that detailed multiorgan immunotherapy-related adverse events in patients treated with atezolizumab. Last, we’ll review the FDA’s approval of the RET-targeted therapy pralsetinib in patients with metastatic RET fusion–positive non–small cell lung cancer.

Coverage of stories discussed this week on ascopost.com:

Addition of Veliparib to Carboplatin/Paclitaxel in Previously Treated Patients With BRCA -Mutated Advanced Breast Cancer: BROCADE3 Trial

New Study Focuses on Multiorgan Immunotherapy-Related Adverse Events in Clinical Trials

FDA Approves Pralsetinib for Metastatic RET Fusion–Positive NSCLC

To listen to more podcasts from ASCO, visit asco.org/podcasts.

From the Archive: Insights on Young-Onset Colorectal Cancer Sep 04, 2020

Show notes

Due to the unexpected passing of actor Chadwick Boseman on August 28, there has been a renewed interest in young-onset colorectal cancer. Mr. Boseman, known for his roles in Black Panther, Marshall, and Get on Up, was only 43 when he died from colon cancer. This week, we’ll go back in The ASCO Post Podcast archives and hear from Kimmie Ng, MD, MPH, who was first on the show about a year ago, offering her insights on the rising rates of colorectal cancer in young adults.

Highlights From the IASLC Virtual Presidential Symposium Aug 28, 2020

Show notes

This week on The ASCO Post Podcast, we'll first hear about a study of the monoclonal antibody sintilimab in combination with pemetrexed and platinum to treat advanced nonsquamous non–small cell lung cancer. Then we'll review the results of the CheckMate 743 trial, which suggest a new standard of care in first-line treatment of unresectable malignant pleural mesothelioma.

Decline in Non–Small Cell Lung Cancer Mortality From 2013 to 2016 Aug 21, 2020

Show notes

We’ll first hear about a study that found a steep decline in non–small cell lung cancer mortality from 2013 to 2016. Then, we’ll close out with a review of a report on the addition of locoregional radiotherapy to chemotherapy in patients with chemotherapy-sensitive metastatic nasopharyngeal carcinoma.

Coverage of stories discussed this week on ascopost.com:

Study Suggests Drop in Non–Small Cell Lung Cancer Mortality Rates Due to Treatment Advances, Reduction in Incidence

Addition of Locoregional Radiotherapy to Chemotherapy for Metastatic Nasopharyngeal Carcinoma

Pathologic Complete Response in the I-SPY2 Trial Aug 14, 2020

Show notes

This week, we’ll start with a follow-up analysis of pathologic complete response in patients participating in the I-SPY2 trial. Then, we’ll move on to a study that sought to answer whether a longer time from diagnosis to surgical treatment lowered overall survival in women with early-stage breast cancer. Last, we’ll hear about how the COVID-19 pandemic is worsening disparities in cancer care among racial and ethnic minorities and the medically underserved.

Coverage of stories discussed this week on ascopost.com:

Association of Pathologic Complete Response With 3-Year Outcomes in I-SPY 2 Trial of Neoadjuvant Therapy for Stage II or III Breast Cancer

Increased Time to Breast Cancer Surgery May Not Impact Overall Survival for Patients With Early-Stage Disease

New Guidelines on Cervical Cancer Screening Aug 07, 2020

Show notes

This week, we’ll review recommendations from a new guideline issued by the American Cancer Society on cervical cancer screening. Then, we’ll discuss the FDA’s approval of a triplet therapy for advanced melanoma. Lastly, we’ll hear a summary of a panel discussion on telehealth for patients with cancer during the COVID-19 pandemic.

Coverage of stories discussed this week on ascopost.com:

American Cancer Society Updates Guideline for Cervical Cancer Screening

FDA Approves Atezolizumab Plus Cobimetinib/Vemurafenib for Advanced BRAF V600–Mutated Melanoma

Comparison of Two Combination Treatments in Localized Pancreatic Cancer Jul 31, 2020

Show notes

This week, we’ll discuss a study that compared two combination treatments for previously untreated patients with localized pancreatic cancer. Then, we’ll explore whether a longer-established diagnosis of cancer is associated with higher risk of severe COVID-19 infection or death from the virus. Last, we’ll review the FDA’s recent approval of a CAR T-cell immunotherapy for patients with relapsed or refractory mantle cell lymphoma.

Coverage of stories discussed this week on ascopost.com:

First-Line FOLFIRINOX vs Gemcitabine/Nab-paclitaxel for Localized Pancreatic Cancer

Are Patients With a Longer-Established Diagnosis of Cancer at Higher Risk for More Severe Infection or Death From COVID-19?

FDA Approves Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma

Cabozantinib for Patients With Advanced Bladder Cancer Jul 24, 2020

Show notes

This week, we’ll discuss phase II results on cabozantinib in patients with advanced bladder cancer. Then, we’ll review a study on behaviors related to COVID-19 prevention among cancer survivors. Lastly, we’ll hear a discussion about the keynote lecture presented at the First International Summit on Interventional Pharmacoeconomics.

Coverage of stories discussed this week on ascopost.com:

Cabozantinib in Platinum-Refractory Metastatic Urothelial Carcinoma

Cancer Survivors Are Adhering to COVID-19–Related Preventive Behaviors, but Continuity of Care May Be Impacted

Lenvatinib Plus Pembrolizumab for Patients With Advanced Gastric Cancer Jul 17, 2020

Show notes

This week, we’ll discuss the efficacy of the combination of lenvatinib and pembrolizumab for patients with advanced gastric cancer. We’ll also highlight key points from the recent USPSTF draft recommendation on CT screening for lung cancer. Finally, we’ll review a regulatory approval in metastatic bladder cancer and hear from the principal investigator of the confirmatory trial.

Coverage of stories discussed this week on ascopost.com:

Lenvatinib Plus Pembrolizumab for Advanced Gastric Cancer

USPSTF Issues Draft Recommendation Statement on Screening for Lung Cancer

FDA Approves Maintenance Avelumab for the Treatment of Advanced Urothelial Carcinoma