Solving the Puzzle with Dr. Datis Kharrazian

Episode 45: Understanding Chronic Viral Infections Oct 21, 2024

In this episode Dr. Kharrazian explores the world of chronic infections, such as Epstein-Barr Virus (EBV), Hepatitis C, Covid, and Human Cytomegalovirus (CMV), and their impact on our immune system. He explores how some pathogens hide within our bodies and reemerge when our immunity is compromised.

He discusses the latest research linking these infections to autoimmune diseases and even cancer, and emphasizes the importance of enhancing our immune defenses rather than just relying on antiviral treatments. He covers a wide range of topics from the basics of virology, the dynamics of long COVID, and the sobering realities of Hepatitis C and Human Papillomavirus (HPV), to the ripple effects of viral infections on our overall health.

Learn more at drknews.com

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

00:00 MHC proteins activate cells to fight infection.

06:16 Long COVID factors: comorbidities, age, severity, inflammation, genetics

13:50 Viral infection can trigger chronic inflammatory conditions.

17:27 Long COVID linked to persistent antinuclear antibodies.

22:53 Autoantibodies may form due to SARS-CoV-2 infection.

27:28 Hepatitis B virus vaccine increases MS risk.

33:58 Alphaviruses include herpes, 53% exhibit antibodies.

39:30 Cytomegalovirus linked to autoimmune diseases, immune manipulation.

45:39 Chronic Epstein Barr causes inflammation, cancer risk.

52:02 Hepatitis C symptoms: diverse and system-wide impacts.

57:33 High treatment costs spark global protests, denials.

01:00:33 PCR measures viral load; biomarkers assess liver damage.

01:06:08 Identify underlying health issues causing recurring infections.

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Episode 44: Chronic Infections and the Immune System May 19, 2024

This episode explores the world of the immune system's response to pathogens and chronic infections. Dr. Kharrazian discusses the intricate mechanisms pathogens use to evade the immune system, leading to chronic infections and reactivations. He speaks on the impact of immune compromise, genetic factors, and other environmental influences on the severity of infections and autoimmune diseases. He also discusses the pivotal role of protein intake, the formation of antibodies, and the potential link between pathogen-induced inflammation and neurodegenerative diseases.

Learn more at drknews.com

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

00:00 Different pathogens have unique effects on health.

06:30 Local infection can trigger widespread systemic inflammation.

10:32 Chronic infections can reactivate and cause autoimmunity.

18:51 Pathogens can lead to Alzheimer's disease development.

24:38 Inflam aging causes inflammation and body pain.

27:47 Blood contains complement systems, T and B cells, and innate adaptive immunity. Persistent pathogens hide in tissues, evade immune barriers. Chronic infections indicate immune system issues.

33:02 Complement proteins indicate pathogenic load in blood.

40:40 Importance of proteins in immune system activation.

46:00 Genetics impacts response to viral infections.

49:28 Weakened immunity can cause severe cytokine storms.

55:02 Tick and pathogen invasion into tissues explained.

58:53 Micronutrient deficiencies can impact immune compromise significantly.

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Episode 43: Hormonal Imbalance Overview Apr 30, 2024

In this episode, Dr. Datis Kharrazian discusses hormone disorders and their impact on puberty, perimenopause, menopause, and andropause. He discusses the onset of hormone-related issues, such as puberty and perimenopausal transition, and provides evidence-based strategies for addressing menstrual irregularities, hormone imbalances, adrenal function, and more. Dr. Kharrazian also delves into the effects of hormone replacement therapy (HRT), the role of essential fatty acids and seed oils, and the impacts of stress on hormone levels. Additionally, he answers questions on hormone therapy, hormone depletion, and the evaluation of pituitary tumors. Listeners will gain insights into managing hormone-related health conditions and understanding the complexities of the endocrine system.

Learn more at drknews.com

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

00:00 Addressing imbalances, electrolyte depletion, and functional medicine.

04:42 Underweight PCOS patients need specific health care.

07:17 Chart discussed general symptoms, diagnostic steps, treatment.

10:32 Analyze protein and fat intake for health.

15:30 Weight loss can release stored toxins and hormones.

18:29 Steroids and sleep, light, sound sensitivity strategies.

20:14 Perimenopausal insomnia and low testosterone concerns addressed.

23:31 Podcast content not a substitute for medical advice.

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Episode 42: Hormone Therapy Strategies Mar 11, 2024

In this episode, Dr. Kharrazian provides insights on growth hormone deficiency, testosterone replacement therapy, strategies for PCOS and infertility, and much more. From discussing the use of growth hormone stimulating peptides to addressing heavy menstrual bleeding and gallbladder issues, this episode offers evidence-based approaches to optimizing endocrine function.

Learn more at drknews.com

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

00:00 Gradual use of HRT therapy based on age.

08:27 Customized hormone therapy starts with low doses.

13:03 Testosterone therapy aids weight loss in men.

20:15 Testosterone replacement therapy may benefit men with diabetes.

23:10 Testosterone replacement therapy in men is safe.

30:20 Men with low testosterone treated with injections.

35:05 Managing testosterone levels in men, potential issues.

38:09 Dietary and lifestyle strategies impact hormones clinically.

48:13 Music therapy, blood sugar, ketogenic diet, sleep issues.

52:33 Nutraceuticals impact insulin resistance; fasting benefits.

56:09 Women in menopause may experience gallbladder issues.

01:03:26 Nutraceutical protocols, insulin signaling, PCOS treatment options.

01:10:20 Evaluate hypoglycemia, insulin resistance, and dietary history.

01:16:18 Decide on hormone therapy based on risks.

01:17:43 Understanding aging and its impact on health.

01:22:32 Podcast content not a substitute for medical advice.

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Episode 41: Understanding Hormone Disorders Mar 05, 2024

In this episode we dive into the intricate web of hormone imbalances, menstrual disorders, and andropause. We explore the impact of estrogen and progesterone imbalances on the menstrual cycle, as well as the role of prostaglandin imbalances in conditions like dysmenorrhea and PMS. We also uncover the complexities of andropause in males and address the various symptoms and treatment options available.

Learn more at drknews.com

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com

00:00 Female and male hormone transition patterns summarized.

08:51 BMI impacts endocrine system, genetic factors matter.

12:40 Excessive estrogen production causes gynecomastia in men.

18:51 Prostaglandins influence menstrual pain and discomfort.

26:21 Causes of heavy or light menstrual bleeding.

32:24 High DHE and testosterone levels suggest PCOS.

33:24 PCOS symptoms can normalize with metabolic control.

38:45 PCOS pathophysiology, treatment, and clinical manifestations.

45:19 Adrenal glands help manage perimenopausal symptoms.

49:33 Hormonal changes in perimenopause cause inflammatory response.

59:03 Inflammation and hormones affect women's health.

01:03:18 Menopause can worsen underlying health conditions.

01:06:44 Adulthood: decline in male function and symptoms.

01:13:49 LH levels range indicates potential hormone balance.

01:16:27 Free testosterone is crucial, especially as we age.

01:25:04 Normal range testosterone, relative hypogonad men, DHT.

01:27:26 Male and female hormone disorders patterns explained.

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Episode 40: Hormone Balancing through Gut Health Feb 19, 2024

In this episode, Dr. Kharrazian delves into the world of hormone imbalances, microbiome diversity, and the impact of polyphenols and phytoestrogens. He discusses evidence-based strategies for autoimmune disease, brain health issues, and chronic health conditions, and sheds light on the pivotal role of gut health in estrogen metabolism. He also addresses nutraceutical support for insulin resistance and regulating testosterone.

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

00:00 Transitioning off HRT may benefit from modulators.

06:05 Flavonoids affect estrogen receptor, 4 key foods.

10:05 Healthy microbiome diversity enhances effectiveness of soy products.

11:16 Carbs impact conversion of phytoestrogens efficiently.

16:29 Gut health crucial for managing estrogen disorders.

18:57 Diet, lifestyle, supplements affect microbiome diversity.

20:53 Liver pathways detoxifying hormones, potential competition. Nutrients aid hepatic inflammation support.

26:51 Essential fatty acids are critical for health.

30:29 Prostate glands cause pelvic issues, need support.

34:19 Men's testosterone, estrogen testing, insulin resistance, obesity, blood sugar imbalances, hypoglycemia, insulin resistance, dietary guidelines.

36:02 Optimize diet to prevent blood sugar crashes.

39:41 Review found herbal medicines improve PCOS symptoms.

42:41 Aggressive protocol for PCOS using nutraceuticals.

47:19 Nutraceuticals may protect serotonin cells, boost testosterone.

50:44 Botanicals boost testosterone levels but may vary.

53:42 Glial cells switch to pro-inflammatory state. Hormone changes amplify neuroinflammation.

56:35 Peptides stimulate hormones, potential for endocrine treatment.

58:37 Dr. Kharrazian's podcast and blog information.

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Episode 39: Hormone Imbalance & Obesity Jan 31, 2024

In this episode, Dr. Kharrazian provides insight into the impact of obesity on male and female hormone imbalances, infertility, and the body's endocrine system. From the role of adipose tissue to the effects of hormone replacement therapy, this episode explores the complexities of hormone balance and offers evidence-based strategies for managing these crucial aspects of health. Dr. Kharrazian discusses blood glucose management, gut health, and the impact of hormone deficiencies on mitochondrial function and other aspects of physiology.

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

Learn more at drknews.com

Timestamps:

00:00 Hormones impact mitochondria, affecting cellular function.

09:31 Mitochondrial health affects recovery and signaling pathways.

12:00 Hormone replacement may fix mitochondrial dysfunction. Stress affects mitochondria.

16:22 Certain genetic factors can increase health risks.

25:26 Aromatization causes body fat increase, vicious cycle.

31:00 Estrogen drop in women leads to fat tissue.

32:52 Steroid use can disrupt endocrine system balance.

42:35 Healthy adrenal function is crucial in perimenopause.

48:03 Adrenal gland imbalances and stress responses summarized.

53:04 Insulin resistance causes blood sugar roller coaster.

57:10 Symptom patterns indicating early stages of insulin resistance.

01:02:30 Gut bacteria convert chemicals and hormones.

01:08:19 Hormone deficiency causes leaky gut, affecting health.

01:12:26 Inflammatory diets cause low testosterone levels.

01:20:18 Hormones critical for health and disease prevention.

01:23:28 Hormone imbalances affect brain recovery and health.

01:28:20 For more info visit drknews.com/podcast.

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Episode 38: Hormone Imbalance and Environmental Toxins Jan 17, 2024

In today's episode, we dive into the impact of hormone imbalance on overall health. From the critical role of adequate sleep in hormone regulation to the potential effects of environmental chemicals on endocrine function, Dr. Kharrazian shares valuable insights and evidence-based strategies for managing hormone imbalances.

For patient-oriented courses, visit https://drknews.com/online-courses/

For CE and CME practitioner courses, visit https://kharrazianinstitute.com/

Learn more at drknews.com

00:00 Toxic chemicals in everyday products, impacts on health.

09:13 Endocrine disrupting chemicals impact female reproductive function.

12:57 Endocrine disrupting chemicals impact PCOS in females.

18:47 Endocrine disrupting chemicals impact serious health conditions.

22:17 Inflammation impacts male testosterone and female infertility.

32:18 Aquifers impact water supply with hormones, pharmaceuticals.

34:54 Use multiple layers of water filtering systems.

43:10 Air pollution impacts cortisol and microbiome health.

48:26 Intense exercise is important for hormonal balance.

52:57 Low or high body mass affects hormones.

58:06 Injections are crucial for male obesity issues.

01:03:36 Muscle mass affects health risks in obesity.

01:08:32 Suppressed FSH, low TSH, hormone-related issues.

01:12:27 Hormones, sleep, and strategies for better rest.

01:19:50 Minimum needed protein is 1g/lb body weight.

01:24:18 Blood sugar: Hypoglycemia vs insulin resistance management.

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Episode 37: Personalized Strategies for Balancing Hormones Jan 02, 2024

In this episode, we take a deep dive into the intricate world of hormone imbalances and hormone replacement therapy. Dr. Kharrazian discusses the latest research findings, revealing a clear linear dose-response relationship between oral contraceptive use and the risk of hypertension, as well as the links between hormone replacement therapy and various health concerns. We explore the complexities of hormone disorders and the need for a personalized approach to treatment, discussing the impact of hormones on clinical function, the liver, and the gut microbiome. Join us as we uncover the vital connection between hormones and overall health, as well as the challenges individuals face in receiving appropriate evaluation and treatment for hormone-related issues in the current healthcare system.

Learn more at drknews.com

00:00 Hormone disorders treated with diverse approaches.

08:13 Hormone replacement therapies and over-the-counter options.

14:10 Different types of hormonal contraceptives can cause weight gain and mood disorders.

18:50 Glial cells produce main hormone for synaptic activity.

25:45 Hormone replacement therapy not recommended for everyone.

30:43 Testosterone therapy shows health benefits with low risk.

37:49 Variety of lifestyle strategies for hormone balance.

39:54 Viral infection may require immediate symptom management.

48:43 Stimulating dysfunctional gland, hormones, pituitary issues, hormones.

53:18 Protein pathways impact hormone levels causing symptoms.

58:19 Androgel may not effectively metabolize into hormones.

01:02:16 Microbiome dysbiosis consequences, particularly linked to hormones.

01:08:23 Estradiol strongest, estrone not as strong.

01:11:19 Urinary labs may not accurately test hormones.

01:16:20 Maintain resiliency for hormone levels, health longevity.

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Episode 36: How chronic systemic inflammation impacts the body and brain Oct 31, 2022

In this talk, Dr. Kharrazian reviews the many pathways through which inflammation impacts the body. In a nutshell, inflammation is like throwing fuel onto the fire. Wherever you already have issues with pain or inflammation, an inflammatory diet and other triggers will simply worsen those conditions. Aging is another consideration — as we age we naturally become more prone to inflammation due to the gradual decline of the body's antioxidant systems. You will learn about these mechanisms, how to find triggers of inflammation, and anti-inflammatory and antioxidant strategies to mitigate the damage.

Find out more on drknews.com.

[00:00:24] . So now, when you're looking at what causes inflammation, the first answer is an imbalance of free radicals and antioxidants. Inflammation can also be caused by an imbalance of our microbiome. Systemic inflammation caused by imbalance of free radicals/antioxidants and microbiome.

[00:23:37] Antioxidants and anti-inflammatories protect body from free radicals; various compounds have different mechanisms; common ones include vitamin E, fish oils, antihistamines, resveratrol, turmeric, vitamin A, vitamin C, and liposomal glutathione.

[00:26:06] C reactive protein is a blood biomarker used as a general marker for inflammation. High levels (over 3 or 5) can indicate disease, but not all inflammation increases production of CRP.

[00:30:21] Insulin resistance causes chronic inflammation, immune response, free radicals and oxidative stress, leading to tissue damage.

[00:32:30] Exercise can cause inflammation in those with chronic conditions, so they should work their way up, clean their diet, and take antioxidants.

[00:34:45] Neurogenic inflammation triggered by stress, lack of sleep and unhealthy relationships.

[00:37:52] Turmeric has active curcuminoids that have an anti-inflammatory effect; people have different cost-benefit ratios for using it; other anti-inflammatory compounds may be more effective for some people.

[00:43:36] Gut Puzzle program teaches diet, lifestyle, and understanding of gut dysfunctions to treat sibo and other conditions.

[00:46:41] Cortisol has a bi-directional effect on inflammation, health, and gut; acute stress is anti-inflammatory, chronic stress is catabolic and can create inflammatory responses.

[00:51:09] Gut motility problems, such as those caused by inflammation and neurodegenerative diseases, can lead to chronic constipation. Gut Health Puzzle program teaches how to address these issues.

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Episode 35: Is it really SIBO? Aug 24, 2022

The concept of small intestinal bacterial overgrowth is one that is becoming very popular but also widely misunderstood and confusing. Compared to the large intestine, there are very few bacterial species in the small intestine. When SIBO happens, the bacteria in the large intestine translocate to the small intestine causing fermentation, bloating, and excessive distension. Foods that commonly trigger SIBO symptoms include fibrous foods, sugar, sweeteners, prebiotics, and fermented foods.

However, not all bloating and distension is SIBO. This is where confusion comes from. In this episode, I discuss how to tell it really is SIBO, SIBO tests, what causes it, and what to do about it.

Find out more on drknews.com.

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Episode 34: Brain problems cause gut problems Aug 17, 2022

Chronic gut health problems some people face can stem from brain-related dysfunction. Key groups of brain-related problems can cause gut problems: neurodegeneration, traumatic brain injury, neurological autoimmunity, and neurodevelopment disorders.

In this episode, I discuss these key categories of brain-related problems and how they affect the gut through the vagus nerve as one of its functions is activating the gastrointestinal tract.

Find out more on our website at Drknews.com.

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Episode 33: Glutathione: Your Most Important Defense Apr 22, 2022

Glutathione is the body’s master antioxidant, meaning it helps protect your cells from pathogens such as viruses. It also lowers the risk of developing food and chemical sensitivities, and is a powerful ally in managing autoimmunity and preventing tissue destruction.

Unfortunately, environmental toxins, chronic stress, unhealthy diets, inflammation, medications, alcohol, aging, and many other factors continually deplete glutathione. Making sure your glutathione status is strong and reducing glutathione depletion can play a profound role in immune resilience to viruses and in managing autoimmune disease, inflammation, chemical sensitivities, food sensitivities, and other chronic health issues.

In this podcast, Dr Kharrazian discusses what glutathione really is, and the supplements and precursors that come in many different forms. How do you know which one to take? How much should you take? How can you tell it's working?

Find out more on our website at Drknews.com

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Episode 32: What thyroid lab tests really tell you Apr 15, 2022

A complete thyroid panel can tell you about thyroid function, feedback loops, and how thyroid hormones are converting. The main thyroid markers are TSH, the pituitary hormone-stimulating gland, and T4 and T3, which are produced by the thyroid gland. Thyroid hormones are bound to proteins called thyroid hormone-binding globulins. Those are total T4 and total T3. T4 is converted to T3, which also makes reverse T3. At some point, thyroid-binding globulin levels release the T3 and T4, which then become free T3 and free T4. You can have defects all along these pathways, which I discuss in this podcast.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 31: Hypothyroidism and gallbladder function Apr 01, 2022

If you have hypothyroidism, the first question you have to ask yourself is how long did it take to finally get diagnosed? Most people do not receive a diagnosis immediately after symptoms appear. What happens to most people instead is they struggle with symptoms for months or years: Hair loss, constipation, cold hands and feet, fatigue – symptoms get worse and worse and they keep developing new ones. Yet their doctor says their lab tests are normal until their thyroid function is bad enough to receive a diagnosis or they find a knowledgeable doctor. By then their body has been deprived of thyroid hormone for quite some time. One problem that can lead to is gallbladder sludge and gallstones. Gallbladder congestion in turns leads to poor absorption of fat-soluble vitamins such as vitamin D, which cascades into other health problems.

This is one reason gallbladder issues are so common among hypothyroid patients.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 30: Common autoimmune diseases among thyroid patients Mar 30, 2022

If you have hypothyroidism, there is a greater than 90% chance that Hashimoto's, an autoimmune disease, is the cause of your hypothyroidism. If you have one autoimmune disease, then you probably have other autoimmune diseases.

Researchers once believed that autoimmunity was an isolated dysfunction of the gland from an autoimmune response that had no other systemic effects.

Current research shows autoimmunity stems from immune dysregulation and loss of immune tolerance – meaning the immune system loses tolerance to foods, chemicals, and its own body tissue.

This means that any tissue in the body is vulnerable to autoimmunity, and that the mechanisms that set into motion one autoimmune disease can lead to another.

The goal is to regulate immune function and drive autoimmune expression into remission, which will lower your risk of developing future autoimmune diseases.

You do this by identifying your triggers and following strategies that dampen inflammation and boost immune *regulation.* How you do this makes up the bulk of my content on my site (drknews.com) and in my books (on amazon).

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 29: What thyroid antibody levels tell you about Hashimoto's Mar 17, 2022

The two main antibodies to screen for Hashimoto’s are thyroid peroxidase (TPO) antibodies and thyroglobulin (Tg) antibodies. It’s important to check both because either one can be elevated, although TPO is more commonly elevated. An important thing to understand about thyroid antibodies, which are used to screen for autoimmune Hashimoto’s hypothyroidism, is that the antibody itself isn't directly related to the severity of the disease. The T cell immune response, which attacks tissue tagged by antibodies, also plays a role.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 28: Why is it so hard to get a hypothyroidism diagnosis Mar 10, 2022

Why is it so difficult to get diagnosed with hypothyroidism and Hashimoto's in the current healthcare system? As a healthcare practitioner, it's pretty rare when a patient says, "Yeah, I had symptoms and right away they diagnosed me with hypothyroidism.” Several reasons go into why it’s hard to get a hypothyroidism diagnosis:

• The disease comes on slowly so it can go misdiagnosed for years.

• Doctors do not screen for thyroid antibodies that would catch early Hashimoto’s because it’s not covered by insurance or considered standard of care.

• Conventional lab ranges are too wide.

• TSH can fluctuate up and down and may be normal at the time of the test.

• HMO doctors are assessed based on how much each of their patients cost and avoid tests they feel are unnecessary.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 27: Which thyroid medication is the best? Feb 25, 2022

In this episode Dr. Kharrazian discusses the commonly asked question, which thyroid hormone replacement works best? The important thing to understand is there is not one optimal thyroid replacement. Issues exist with all types of replacement depending on the person and their unique situation and needs. Each person must figure out what their challenges and needs are and which thyroid hormone is most appropriate for them.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 26: How hypothyroidism affects blood sugar stability Feb 16, 2022

Do you feel sleepy after you eat? Or do you feel energized after eating? Both responses indicate blood sugar instability. Chronically high blood sugar, low blood sugar, or swings between the two cause Hashimoto's flare ups and make the condition difficult to manage. At the same time, if you're in a low thyroid state from undiagnosed or poorly managed Hashimoto's, you're also susceptible to poor blood sugar handling. Low thyroid states both prevent uptake of glucose and promote insulin resistance.

Subscribe to be notified of the free Hashimoto's webinar at drknews.com.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 25: Chelation therapy risks Dec 26, 2021

Today’s world is very toxic, and we all carry toxic chemicals and heavy metals in our bodies. Chelation is a popular therapy to lower heavy metal levels, however it’s important to be aware of the risks—chelation can significantly worsen health in vulnerable people. Factors to consider include your antioxidant status, blood-brain barrier permeability, immune tolerance, gut health, autoimmune status, microbiome, and more. In this talk, Dr. Kharrazian covers heavy metal and chemical toxicity, risk factors to consider before chelation, forms of heavy metal testing, and daily strategies to lower the burden of toxins on your body.

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Episode 24: Endotoxemia: A hidden landmine for multiple health disorders Dec 15, 2021

Endotoxemia happens when toxic byproducts from harmful gut bacteria escape through a leaky gut wall into the bloodstream. Here, they trigger significant inflammation throughout the body. Endotoxemia is linked with major depressive disorder, autoimmunity, joint disease, skin problems, poor immune resilience, difficulty recovering, aging poorly, and more. In fact, one thing people who live to 100 have in common is low levels of endotoxemia. Research also shows people with endotoxemia have a lower chance of surviving a critical illness or sepsis. In this talk, Dr. Kharrazian talks about the factors that cause endotoxemia, why it is considered the most severe form of leaky gut, and strategies for recovery. A Q&A with viewers follow. (From his Facebook Live 12-17-2020). To learn more about improving gut health, visit the online course Gut Health: Solving the Puzzle.

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Episode 23: How gluten impacts Hashimoto's & hypothyroidism Dec 08, 2021

Contrary to popular belief, gluten intolerance is not a fad. Rates of gluten intolerance have risen dramatically due to many factors of industrialization. Unsurprisingly, significant links exist between gluten and autoimmunity, particularly Hashimoto's hypothyroidism. People with Hashimoto's low thyroid are more genetically prone to gluten sensitivity and celiac disease. Standard gluten sensitivity testing misses about 20% of positive cases because they only test for alpha gliadin. In truth, people can react to multiple compounds in wheat, which should be included in immune reactivity testing. Testing should also screen for the transglutaminase antibodies typically seen in celiac disease, a more destructive form of gluten sensitivity. Learn more in this podcast about how to correctly identify a gluten sensitivity and follow a gluten-free diet to better manage your Hashimoto's or other autoimmune disease.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

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Episode 22: Hashimoto's and hypothyroidism Q&A -- Part 3 Dec 01, 2021

In this video, Dr. Kharrazian answers questions from members of the course Hashimoto's: Solving the Puzzle (drknews.com). Topics include:

The role of thyroid binding globulin and the potential effect of birth control pills and hormone replacement.
Stubbornly high TPO antibodies.
The role of low dose naltrexone (LDN).
What does it mean when TSH is low?
What causes the swings between hyperthyroid and hypothyroid symptoms?
Can hypothyroidism cause chronic sinus infections?
The link between hypothyroidism and ferritin levels.
Why are all my glands low functioning?
What is myo-inositol and how can it help?
Should I be worried about low serum iodine levels?
Can I get off my thyroid meds or reduce the dosage?
Do I need a thyroid ultrasound?
What if I have symptoms of Hashimoto's but antibody tests are repeatedly negative?
How do we find a competent healthcare professional to work with?
Should I use bentonite clay?
I developed Hashimoto's after having my ovaries and uterus removed.
How do I reduce my reactions to chemicals?
Does low vitamin D mean I have an infection?

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 21: Hashimoto's and hypothyroidism Q&A -- Part 2 Nov 24, 2021

In this video, Dr. Kharrazian answers questions from members of the course Hashimoto's: Solving the Puzzle (drknews.com). Topics covered include: The optimal TSH level, food sensitivities and Hashimoto's, low thyroid symptoms but no diagnosis, testing total immuoglobulins before Cyrex testing, antibody testing when on immunosuppressants, CIRS and the Shoemaker protocols, why TPO antibodies are high yet TSH is normal, why symptoms swing between hypo and hyperthyroid, non-Hashimoto's causes of hypothyroidism, negative antibodies yet positive biopsy, thyroid hormone "injections," Hashimoto's and high cholesterol, hair dye and bleach, healing nodules, and thoughts on iodine.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 20: Hashimoto's and hypothyroidism Q&A -- Part 1 Nov 17, 2021

In this video, Dr. Kharrazian answers questions from members of the course Hashimoto's: Solving the Puzzle (drknews.com). Topics covered include what your thyroid antibodies mean for your Hashimoto's symptoms, how to know if a particular lab is reliable, coffee enemas, the impact of adrenal exhaustion on Hashimoto's, when to take your thyroid meds before lab testing, thyroid--brain concerns, why you may still have thyroid symptoms despite taking thyroid meds, and concerns regarding Hashimoto's, covid, and the covid vaccine.

To learn more, visit the siteor the online Hashimoto's: Solving the Puzzle course page.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 19: The vagus nerve and gut health Nov 11, 2021

In this video, Dr. Kharrazian explains how the vagus nerve affects digestion and other aspects of gut health, factors that can compromise vagus function, and the best ways to strengthen your vagus nerve . Not all vagal exercises are alike and you want to use the most effective ones. Dr. Kharrazian has worked with many patients over the years whose gut health was significantly compromised from poor vagal tone, particularly those impacted by brain injury.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 18: How hypothyroidism causes depression and anxiety Oct 27, 2021

If you struggle with chronic depression, anxiety, or other mood disorders, you may suffer from undiagnosed hypothyroidism. A thyroid hormone deficiency can cause multiple brain-based symptoms. This is because thyroid hormones play an important role in the function of many areas of the brain, including neuron health, brain immune cells called neuroglia, and the blood-brain barrier. If you have a chronic mood disorder, consider asking your doctor to screen for hypothyroidism with a TSH test and for autoimmune Hashimoto’s with a TPO and TGB antibody test in order to rule these conditions out. Learn more in this podcast episode or in my online course, Hashimoto's: Solving the Puzzle.

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Episode 17: The best (and worst) supplements for Hashimoto's hypothyroidism Oct 20, 2021

Not all thyroid supplements are equally effective – in fact, some can actually make your hypothyroid symptoms worse. You might have come across the mistaken belief that hypothyroidism is caused by a nutritional deficiency of iodine, tyrosine, or thyroid glandulars. This is an outdated theory from the 1950s and ‘60s that unfortunately still persists today. In actuality, iodine and tyrosine are not the best options for those with Hashimoto’s – and thyroid glandulars should never be used as a replacement for thyroid medication. However, some nutraceuticals can be very supportive of hypothyroidism and Hashimoto's. Learn more in this episode or check out my course, Hashimoto's: Solving the Puzzle.

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Episode 16: The best diet for Hashimoto's hypothyroidism Oct 13, 2021

It’s an incredibly common question among hypothyroid patients: what’s the best diet for hypothyroidism? While specific diet plans can certainly make a profound impact, for the best results you have to tailor your diet to your individual needs. Outdated myths persist when it comes to the best diets for hypothyroidism, and we should tackle some of those before moving ahead into the best diet options for you. Learn more in this podcast episode or in my course, Hashimoto's: Solving the Puzzle.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 15: Environmental chemicals and hypothyroidism Oct 06, 2021

You might not realize just how many chemicals you encounter on a day-to-day basis. Each of us is routinely exposed to thousands of different chemicals – many of which can impact your thyroid health. Some of these chemicals are cleared out of the body through liver “biotransformation.” Commonly called detoxification, this is the process through which liver enzymes convert chemicals into water-soluble compounds that can be properly eliminated through sweat, urine, and feces.

Chemicals that can be processed and eliminated in this way include pesticides, plastics, fire retardants, and many other chemicals in our food, water, and air.

But there’s a group of chemicals that cannot be cleared out of the body, including heavy metals like mercury, lead, and arsenic. Since they cannot be expelled, metals are stored in the fat and bone. Learn more in this episode or in my course,Hashimoto's: Solving the Puzzle.

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Episode 14: How hypothyroidism affects gut health Sep 29, 2021

If you’ve been diagnosed with hypothyroidism, you should know low thyroid function can impact your gut health. This is why it’s important to properly manage the underlying mechanisms of your hypothyroidism. An intimate relationship exists between your gastrointestinal tract and your thyroid, with each affecting the other. The health of the stomach, gut microbiome, pancreas, liver, gallbladder, and large intestine are all interrelated with thyroid function. Additionally, the inflammation and autoimmune mechanisms associated with Hashimoto’s cause thyroid receptor site resistance and low thyroid function. Learn more in this podcast episode.

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Episode 13: The #1 rule when working on gut health Sep 15, 2021

If you're like 3/4 of Americans, you suffer from IBS, diarrhea, acid reflux, constipation, abdominal pain, leaky gut, SIBO, bloating and gas, and so on. In this podcast Dr. Kharrazian explains the number-one rule he follows when working with any gut health patient: Start at the top and work your way down. If you are trying to improve your microbiome but your gallbladder is congested, you likely won't be successful. If you have IBS symptoms but you're not addressing low stomach hydrochloric acid, or if you are constipated and your brain is dysfunctioning due to a head injury, neuroinflammation, or degeneration, again, your success will be limited. In this information-packed episode, Dr. Kharrazian goes over the broad strategies of addressing gut health disorders and takes questions from viewers.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 12: "Leaky brain" in brain fog, fatigue, and depression Sep 08, 2021

You may have heard of leaky gut but did you know you can get leaky brain too? The most common symptoms are brain fog and slower mental speed, but an intestinal blood-brain barrier plays a role in numerous brain disorders. Learn more in this episode and from great viewer questions.

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Episode 11: Mold toxicity — a silent factor in chronic illness Sep 01, 2021

Mold toxicity is a silent factor a lot of people don’t consider when rooting out causes for chronic health issues. Because most of its signs and symptoms are invisible to everyone else, it often goes unsuspected until symptoms become disabling. Many factors can play a role in mold toxicity, from water damage in your home, school, or workplace, to indoor humidity levels, genetic susceptibility, and your unique immune function. In this podcast, Dr. Kharrazian explains how mold toxicity occurs, what to look out for, ways to test for and address it, and more. Followed by a Q&A with listeners.

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Episode 10: GI symptoms from low stomach acid and gallbladder sludge Aug 25, 2021

Low stomach acid and gallbladders sludge are very common gut issues in Americans. Low stomach acid can lead to symptoms such as acid reflux, heartburn, indigestion, belching and bloating, and discomfort after eating meats and proteins. Gallbladder sludge can lead to belching and bloating, burping up fish oil capsules, and discomfort after eating fats. Both of these disorders lead to problems throughout the digestive tract and can raise your risk of chronic disease. Instead of always reaching for the antacids or other drugs, learn the various underlying causes of these issues and what to do about them in this video. The good news is they often are easily managed. Learn more at drknews.com.

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Episode 9: Histamine and Mast Cell Activation Syndrome (MCAS) Aug 18, 2021

In this episode, Dr. Kharrazian goes over the primary mechanisms of histamine intolerance and mast cell activation syndrome (MCAS). But first, make sure you even have these conditions as these diagnoses are being tossed around a little too casually these days. While the low-histamine diet may reduce symptoms, it does not necessarily address the underlying causes and it deprives you of cultured foods, which support microbiome diversity. Additionally, MCAS is a very serious condition, so make sure your self-diagnosis is valid or you may be addressing the wrong target.

Dr. Kharrazian covers all these topics in a 20-minute talk and then answers questions from viewers. If you suspect you have histamine intolerance or MCAS, this video gives a great foundation from which to move forward.

Synopsis:

Symptoms of histamine intolerance

Skin urticaria
Nasal congestion
Anaphylaxis
Wheezing
Chronic gastrointestinal issues
Chronic migraine issues

Key things to note with histamine reactions

Determine if you actually have histamine intolerance by taking an antihistamine and looking for relief from symptoms.
Multiple food sensitivities doesn't necessarily mean you have a mast cell/histamine response.
Food sensitivities are delayed IgG response or an IgM responses.
Histamine responses involve immediate IgE responses.
An allergic reaction IgE reaction to foods and environmental chemicals activate mast cells, which release chemical mediators, including histamine.

Mast cell activation

Healthy response: Exposure to the antigen triggers mast cells.
Occasional symptomatic response: Occasional reactions to triggers such as pollen or pet dander.
Chronic histamine response: Chronic histamine issues with constant symptoms
Mast Cell Activation Syndrome (MCAS): Massive and chronic mast cell response. The body is producing excess mast cells with exaggerated activity, causing significant and severe symptoms

Things to look at when you have a histamine response

Genetically low DAO enzyme
Methylation issues
Exposure to an allergen that develops IgE reactions, e.g mold, parasitic, Lyme infection
Underlying triggers
What is amplifying the immune responses
Immune tolerance
Other chronic health issues (leaky gut, leaky lung, low vitamin D, etc.)

Mast Cell Activation Syndrome

Mast cell activation stream is the most aggressive form of histamine reaction, has criteria for diagnosis, and may require pharmacological treatment.

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Episode 8: Causes and solutions for chronic bloating Aug 11, 2021

Chronic bloating and abdominal distention are common gut health complaints. In this podcast, Dr. Kharrazian covers the primary causes of bloating and how to start implementing solutions. Multiple things can cause bloating, with the underlying mechanisms depending on the individual. You must work north-to-south in the GI tract to identify where your issues lie. Brain-based mechanisms, chewing, stomach health, pancreatic and gallbladder function, microbiome health, motility, and SIBO are discussed in this podcast, followed by a Q&A with listeners. (This is a replay of a Facebook live from June 2020, you can also watch it on YouTube.)

To learn more about how to identify and address common gut health issues, check out the online course Gut Health: Solving the Puzzle.

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Episode 7: How hypothyroidism affects your appearance Aug 04, 2021

Hypothyroidism, or low thyroid function, impacts your skin, hair, nails, joints, body inflammation, systemic inflammation—all of which affect your physical appearance. The most common cause of hypothyroidism is an autoimmune disease called Hashimoto’s, a disorder that causes the immune system to attack and destroy the thyroid gland. It is an incurable condition but can typically be driven into remission through evidence-backed nutrition and lifestyle strategies.

Hashimoto's creates a heightened state of inflammation. It can also lead to secondary autoimmune diseases that cause hair loss, joint pain, and skin conditions, further affecting appearance.

For many people, thyroid hormone medication alone will not relieve symptoms—the underlying autoimmune condition must be managed as well in order to feel and function better, and address the factors affecting your appearance.

Download Dr. Kharrazian's free guide, Hashimoto's, Hypothyroidism, and the Brain.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 6: How hypothyroidism affects the body and causes a variety of symptoms Jul 28, 2021

What happens to your health when your thyroid hormones are low? In this episode, Dr. Kharrazian talks about the various conditions that can cause low thyroid hormones, including Hashimoto’s disease, improper hormone conversion, and incorrect hormone replacement. He then goes through the impact of thyroid hormone deficiency on different systems in the body and how that can affect symptoms and health. Of particular concern is the impact of neglect or misdiagnosis of hypothyroidism on the brain and the cardiovascular system. Through this podcast episode, we hope to give you a better understanding of how your thyroid works and what to expect when facing hypothyroidism.

Download Dr. Kharrazian's free guide, Hashimoto's and the Brain.

Support this show at: http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Episode 5: Gluten and Chronic Health Conditions Jul 02, 2021

Gluten is a much more complex topic than most people realize. First of all, most gluten sensitivity testing is extremely limited as it only tests alpha gliadin. The truth is, people can react to many different portions of wheat, including the lectins in wheat agglutinin, and various other gliadans besides alpha gliadin. Unless you screen for an immune reactivity to all of these compounds using ELISA testing, you may end up with a false negative result.

Secondly, people can have varying reactions that can include cross reactivity between gluten and other foods or body tissue, autoimmune reactivity involving transglutaminase enzymes, and more depending on their type of gluten sensitivity. Wheat is not the same compound it was 50 years ago due to hybridization and heavy glyphosate use, which research suggests accounts for the increase in gluten sensitivity in the population.

Also, it's important to note that 2/3 of reactions to gluten are expressed in the brain and nervous system, not in the GI tract. Learn more in this podcast and from the Q&A session following the talk.

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Episode 4: Understanding PANS and PANDAS Jul 02, 2021

PANDAS and PANS are autoimmune brain disorders that affect children in the aftermath of a strep infection or other infections. Symptoms include sensory, emotional, or movement disorders. These conditions are often misunderstood, misdiagnosed, and inappropriately treated. In this talk, I explain what causes PANDAS and PANS, lab testing, management strategies, and expected challenges in working with children. I then answer listener questions.

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Episode 3: How Gluten Affects the Brain Jul 02, 2021

Do you suffer from fatigue, brain fog, depression, cognitive issues, mood or psychiatric issues, or memory loss?

A gluten sensitivity manifests neurologically in 2/3 of people — most people do not have gut symptoms in response to gluten. Researchers call gluten sensitivity a neurological disease.

Yet gluten sensitivity is significantly under diagnosed due to incomplete testing. If you have brain fog, cognitive, mood, psychiatric, or fatigue issues, you need to listen to this podcast.

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Episode 2: The Top 10 Triggers of Autoimmune Disease and Flare Ups Jul 02, 2021

Many people think their autoimmune management depends on diet. While diet plays a key role, it does not go the full distance for everyone. The autoimmune journey involves finding your underlying mechanisms and triggers. They are different for everyone...and they are not always obvious. First, you have to know what the possible triggers are. Research has identified quite a few. Then you have to know how to find them, and what to do about them.

In this podcast, I go over the top 10 most common triggers of autoimmunity and then answer questions from listeners.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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