Sensible Medicine

Latest Episodes:

This Fortnight in Medicine XXIV Apr 22, 2026

Show notes

RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults

Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism

* Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon

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This Fortnight in Medicine XXIII Apr 08, 2026

Show notes

Dengue Suppression by Male Wolbachia-Infected Mosquitoes

* World Mosquito Program

Antibiotic Therapy for Uncomplicated Acute Appendicitis

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This Fortnight in Medicine XXII Mar 24, 2026

Show notes

* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study

* Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction

* Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMI

And, a bunch of the other studies we discussed.

* Complete Revascularization with Multivessel PCI for Myocardial Infarction

* FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction

* Initial Invasive or Conservative Strategy for Stable Coronary Disease

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

This Fortnight in Medicine XXI Mar 11, 2026

Show notes

Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study

* A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients

Effect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban Public High Schools

* Why Are So Many Teen Girls Still Tearing Their A.C.L.s?

* Injury prevention programs that include plyometric exercises reduce the incidence of anterior cruciate ligament injury: a systematic review of cluster randomised trials

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Going Beyond "AI in Medicine" Mar 04, 2026

Show notes

Most conversations about “AI in Medicine” bore me. I think this is because either we lack the imagination to consider how AI will change medicine in the next decade, or we are not being specific enough about how small parts of medicine could be productively affected.

Dr. Shantanu Nundy, MD, MBA, is a practicing physician whom I like to think of as a serial innovator. He is currently an advisor on artificial intelligence to the FDA in the Commissioner’s Office. He has spent a great deal of time and energy thinking deeply about what AI can bring us today and in the future. I hope you enjoy this conversation.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

This Fortnight in Medicine XX Feb 25, 2026

Show notes

High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults

* High-Dose Influenza Vaccine to Reduce Hospitalizations

* Efficacy of high-dose versus standard-dose influenza vaccine in older adults

Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Alternative Modalities for Breast Cancer Screening Feb 18, 2026

Show notes

Today on the podcast, I am joined by Dr. Jennifer Rusiecki. Dr. Rusiecki is an Associate Professor of Medicine at the University of Chicago. She is the Director of Women’s Health and Gender-Based Care in the internal medicine residency program and the assistant clinic director overseeing gender-based care.

Dr. Rusiecki and I discussed the article appraised in the other post today, and also discussed the issues of screening for breast cancer in women with dense breasts and breast cancer screening more generally. Dr. Rusieki and I don’t agree on everything, and you might leave more confused than you came, but I still think it is worth a listen.

Some further reading:

The infographic on mammography we discussed.

A recent article on mammogram quandaries.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

This Fortnight in Medicine XIX Feb 11, 2026

Show notes

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial

Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction

* Should Evidence Come with an Expiration Date?

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

This Fortnight in Medicine XVIII Jan 28, 2026

Show notes

No video this week — we had a bit of a computer meltdown — but two interesting articles.

As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at sensiblemedicine2022@gmail.com.

This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Friday Reflection 56: Comments that Stuck Jan 23, 2026

Show notes

In a lifetime of possible memories, only some are accessible. There are a few comments — made by mentors, co-residents, and patients — that have lingered and shaped my medical practice.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

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