Research To Practice | Oncology Videos

Latest Episodes:

Breast Cancer | Oncology Today with Dr Neil Love: Special Edition — Key Presentations from the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting on Breast Cancer Aug 08, 2023

Show notes

Featuring perspectives from Dr Heather McArthur, including the following topics:

Investigator perspectives on recently presented data from clinical trials for HER2-positive localized and metastatic breast cancer (mBC) (0:00)
Racial and ethnic differences in 21-gene Recurrence Score® and survival among patients with ER-positive breast cancer (28:31)
Emerging data with CDK4/6 inhibitors for ER-positive, HER2-negative breast cancer (38:22)
Final overall survival analysis from the TROPiCS-02 study of sacituzumab govitecan for ER-positive, HER2-negative mBC; TROP2 mRNA expression and association with clinical outcomes (1:03:22)

CME information and select publications

Higher-Risk Myelodysplastic Syndromes | David Sallman, MD Aug 02, 2023

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Inside the Issue: Novel Agents, Approaches and Strategies in the Management of Higher-Risk Myelodysplastic Syndromes — Faculty Presentation 2: Future directions in the management of higher-risk MDS — Dr David Sallman

CME information and select publications

Higher-Risk Myelodysplastic Syndromes | Guillermo Garcia-Manero, MD Aug 02, 2023

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Inside the Issue: Novel Agents, Approaches and Strategies in the Management of Higher-Risk Myelodysplastic Syndromes — Faculty Presentation 1: Current management of higher-risk myelodysplastic syndromes (MDS) — Guillermo Garcia-Manero, MD

CME information and select publications

Higher-Risk Myelodysplastic Syndromes | Inside the Issue: Novel Agents, Approaches and Strategies in the Management of Higher-Risk Myelodysplastic Syndromes Aug 02, 2023

Show notes

Featuring perspectives from Dr Guillermo Garcia-Manero and Dr David Sallman, including the following topics:

Introduction (00:00)
Biology of Acute Myeloid Leukemia/Myelodysplastic Syndromes (3:14)
Assessment of Risk Status (14:17)
Oral Hypomethylating Agents (HMAs) (22:24)
HMA/Venetoclax; Other Combinations (31:26)
Magrolimab/TP53 (45:12)

CME information and select publications

Immune Thrombocytopenia | Oncology Today with Dr Neil Love: Management of Immune Thrombocytopenia (Faculty Lecture) Jul 31, 2023

Show notes

Featuring a slide presentation and related discussion from Dr Hanny Al-Samkari, including the following topics:

Indications for initiation of treatment for patients with immune thrombocytopenia (ITP) and selection of first-line therapy (0:00)
Treatment algorithm for ITP in the second line and beyond (7:47)
Role of thrombopoietin receptor agonists and fostamatinib for second- and later-line treatment of ITP (14:21)
Novel investigational approaches for the treatment of ITP — efgartigimod, rilzabrutinib and ianalumab (28:24)

CME information and select publications

Immune Thrombocytopenia | Oncology Today with Dr Neil Love: Management of Immune Thrombocytopenia Jul 31, 2023

Show notes

Featuring perspectives from Dr Hanny Al-Samkari, including the following topics:

Case: A woman in her mid 60s with a past medical history of hypertension and Sjögren's syndrome presents to emergency with diffuse petechiae in her extremities and the taste of iron in her mouth (0:00)
Case: A man in his early 30s with chronic immune thrombocytopenia (ITP) who has been off therapy for 18 months with no constitutional symptoms presents for his 3-month follow-up with platelet count decreased to 29 x 109/L (3:26)
Case: A woman in her mid 60s with chronic ITP who has received multiple treatments over a decade and is resistant to splenectomy presents for follow-up with a platelet count of 11 x 109/L (5:58)
Characterizing immune dysfunction in patients with ITP (7:45)
Perspectives on the approach to initial therapy for ITP (12:23)
Treatment approaches beyond first-line therapy (17:34)
Addressing symptoms and concerns beyond the issue of bleeding for patients with ITP (22:19)
Role of splenectomy in the treatment of ITP (27:08)
CME information and select publications

Chronic Lymphocytic Leukemia | What I Tell My Patients: New Treatments and Clinical Trials — Chronic Lymphocytic Leukemia Jul 28, 2023

Show notes

Featuring perspectives from Ms Kristen B Battiato and Dr Jennifer Woyach, including the following topics:

Introduction (0:00)
Case: A woman in her early 70s responding to ibrutinib for 4 years (27:07)
Case: A woman in her early 80s with TP53-mutant, del(17p) disease responding to acalabrutinib (38:02)
Case: A man in his mid 50s with chronic lymphocytic leukemia/small lymphocytic leukemia treated for a year with obinutuzumab followed by venetoclax; no evidence of disease for 3 years (43:29)
Case: A Cuban woman in her mid 60s with multiregimen-recurrent disease, now receiving venetoclax (53:17)

NCPD information and select publications

Paroxysmal Nocturnal Hemoglobinuria | Oncology Today with Dr Neil Love: Management of Paroxysmal Nocturnal Hemoglobinuria (Faculty Lecture) Jul 26, 2023

Show notes

Featuring perspectives from Dr Carlos M de Castro, including the following topics:

Overview of paroxysmal nocturnal hemoglobinuria (PNH) (0:00)
Complement C5 inhibition for patients with PNH (6:48)
Proximal complement inhibitors for PNH management (17:17)

CME information and select publications

Paroxysmal Nocturnal Hemoglobinuria | Oncology Today with Dr Neil Love: Management of Paroxysmal Nocturnal Hemoglobinuria Jul 26, 2023

Show notes

Featuring perspectives from Dr Carlos M de Castro, including the following topics:

Biology of paroxysmal nocturnal hemoglobinuria (PNH) (0:00)
Evolution of the PNH treatment landscape (13:07)
Selection and sequencing of therapies for patients with PNH (18:09)
Overview and presentation of extravascular hemolysis (23:50)
Case: A woman in her early 40s with PNH who developed Budd-Chiari syndrome and had an excellent response to C5 inhibition (26:57)
Case: A woman in her early 40s with a suboptimal response to ecluizumab followed by an excellent response to pegcetacoplan on the PEGASUS trial (34:00)
Case: A woman in her mid 40s who experienced breakthrough hemolysis with pegcetacoplan and was recently switched to iptacopan (38:40)

CME information and select publications

Renal Cell Carcinoma | Investigator Perspectives on Available Research Findings and Challenging Questions in Renal Cell Carcinoma Jul 17, 2023

Show notes

Featuring perspectives from Dr David F McDermott and Dr Sumanta Kumar Pal, including the following topics:

Introduction (0:00)
ASCO 2023 (1:35)
Management of Advanced Renal Cell Carcinoma (RCC) (17:19)
Treatment Approaches for Nonmetastatic RCC; Optimal Care of Patients with Non-Clear Cell RCC (38:13)

CME information and select publications