Research To Practice | Oncology Videos

Latest Episodes:

Chronic Lymphocytic Leukemia and Lymphoma | What I Tell My Patients: Integrating New Research Information into Current Clinical Care — Chronic Lymphocytic Leukemia and Bispecific Antibodies in the Management of Lymphoma Jun 14, 2024

Show notes

Featuring perspectives from Dr John N Allan, Dr Brad S Kahl, Ms Robin Klebig and Ms Mollie Moran, including the following topics:

Introduction (0:00)
First-Line Therapy for Chronic Lymphocytic Leukemia (CLL) (11:44)
The Impact of Comorbid Conditions on the Choice of First-Line Therapy for Newly Diagnosed CLL (18:08)
Toxicities and Other Practical Considerations with Venetoclax-Based Treatment (25:17)
The Selection and Sequencing of Therapies for Relapsed/Refractory CLL (35:45)
The Tolerability of Available Bruton Tyrosine Kinase (BTK) Inhibitors (40:43)
The Potential Role of Therapy Combining BTK Inhibitors and Venetoclax (48:48)
Bispecific Antibodies as a Treatment Option for Non-Hodgkin Lymphoma (1:04:19)
Cytokine Release Syndrome and Neurotoxicity with Bispecific Antibodies (1:06:25)
Other Tolerability and Toxicity Issues with Bispecific Antibody Therapy (1:10:44)
Bispecific Antibodies for the Management of Follicular Lymphoma (1:18:19)
The Role of Bispecific Antibody Therapy in the Treatment of Diffuse Large B-Cell Lymphoma (1:24:17)
Other Practical Considerations with the Use of Bispecific Antibodies (1:40:59)

NCPD information and select publications

Breast Cancer | Striving for Consensus: Exploring the Current Role of Ovarian Suppression in the Management of Breast Cancer Jun 13, 2024

Show notes

Featuring perspectives from Dr William J Gradishar, Dr Virginia Kaklamani, Dr Erica Mayer and Dr Seth Wander, including the following topics:

Introduction (0:00)
Addition of Ovarian Function Suppression (OFS) to Adjuvant Endocrine Therapy for Premenopausal Patients with Hormone Receptor (HR)-Positive Breast Cancer — Dr Gradishar (4:49)
Case: A woman in her mid 20s with HR-positive, HER2-positive intraductal carcinoma (IDC) who received ovarian suppression with TAC chemotherapy and concurrent trastuzumab/pertuzumab followed by tamoxifen (30:48)
Case: A woman in her late 30s with HR-positive, HER2-negative IDC and no nodal involvement who received postoperative chemoradiation therapy followed by tamoxifen and is considering ovarian suppression (39:31)
Role of OFS in Preserving Fertility and/or Ovarian Function in Premenopausal Patients – Dr Mayer (44:55)
Case: A woman in her early 30s with HR-positive, HER2-positive (IHC 3+) IDC recommended to receive perioperative TCHP who is interested in fertility preservation (1:11:15)
Case: A woman in her mid 30s presenting with ER-positive, HER2-negative breast cancer during early pregnancy who received preoperative TAC and had pathologic complete response at surgery (1:14:18)
Tolerability and Toxicity of OFS – Dr Kaklamani (1:21:21)
Case: A woman in her mid 30s, uninterested in fertility preservation, who received chemotherapy and TAC followed by tamoxifen and abemaciclib for ER-positive, HER2-negative breast cancer (1:39:42)
Case: A premenopausal woman in her late 40s with a 3.6-cm breast tumor and a Recurrence Score (RS) of 26 who becomes amenorrheic with chemotherapy and TC (1:43:32)
Other Practical Considerations in the Application of OFS – Dr Wander (1:46:29)
Case: A woman in her early 50s with HR-positive, HER2 IHC 2+ invasive lobular carcinoma and a RS of 15 who declined chemotherapy and opted to stop adjuvant leuprolide after 1 year (1:59:56)
Case: A woman in her early 40s with HR-positive, HER2 IHC 1+ breast cancer who has no interest in fertility preservation and significant residual disease at surgery (2:14:06)

CME information and select publications

Non-Small Cell Lung Cancer | Justin F Gainor, MD Jun 12, 2024

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Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Targeted Therapy for Non-Small Cell Lung Cancer | Faculty Presentation 2: Therapeutic Approaches for Patients with NSCLC and Other Actionable Genomic Alterations — Justin F Gainor, MD

CME information and select publications

Non-Small Cell Lung Cancer | Karen Reckamp, MD, MS Jun 12, 2024

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Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Targeted Therapy for Non-Small Cell Lung Cancer | Faculty Presentation 1: Management of Non-Small Cell Lung Cancer (NSCLC) with an EGFR Mutation — Karen Reckamp, MD, MS

CME information and select publications

Non-Small Cell Lung Cancer | Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Targeted Therapy for Non-Small Cell Lung Cancer Jun 12, 2024

Show notes

Featuring perspectives from Dr Justin F Gainor and Dr Karen Reckamp, including the following topics:

Introduction: Bringing Research into Practice (0:00)
EGFR Activating Mutations (14:01)
Exon 20 Insertion Mutations (38:06)
MET Exon 14 Alterations (41:49)
HER2 Mutations and Overexpression (50:27)

CME information and select publications

Gastroesophageal and Colorectal Cancers | What I Tell My Patients: Integrating New Research Information into Current Clinical Care — Gastroesophageal and Colorectal Cancers Jun 10, 2024

Show notes

Featuring perspectives from Ms Deanna A Griffie, Ms Caroline Kuhlman, Dr Manish A Shah and Dr John Strickler, including the following topics:

Introduction (0:00)
The Current Role of Anti-PD-1/PD-L1 Antibodies in the Management of Nonmetastatic Gastroesophageal Cancers (11:30)
The Potential Role of Immune Checkpoint Inhibitors (ICIs) as Neoadjuvant Therapy for Patients with Gastric/Gastroesophageal Junction Cancer (20:53)
First-Line Therapy for Metastatic Gastroesophageal Cancers (36:16)
The Potential Role of Therapy Targeting Claudin 18.2 for Gastroesophageal Cancers (42:16)
Targeted Therapies for HER2-Positive Gastroesophageal Cancers (51:42)
Selection of Appropriate Candidates with Localized Colorectal Cancer (CRC) for Adjuvant Therapy (1:14:24)
The Current Role of ICIs in the Treatment of Metastatic CRC (mCRC) (1:23:32)
Tolerability and Other Practical Considerations with ICIs (1:25:57)
The Role of TAS-102/Bevacizumab in the Management of Relapsed/Refractory (R/R) mCRC (1:36:14)
The Potential Role of KRAS-Targeted Therapy in the Management of mCRC (1:44:36)

NCPD information and select publications

Urothelial Bladder Cancer | Second Opinion: Urologic Oncology Investigators Discuss How They Apply Clinical Research in the Care of Patients with Urothelial Bladder Cancer Jun 07, 2024

Show notes

Featuring perspectives from Dr Matthew D Galsky and Dr Ashish M Kamat, including the following topics:

Introduction: Urologist for Life (0:00)
Non-Muscle-Invasive Urothelial Bladder Cancer (UBC) Update (9:54)
Enfortumab Vedotin/Pembrolizumab Now and in the Future (30:21)
HER2-Positive UBC (37:33)
Future Directions — ctDNA (55:39)

CME information and select publications

Myelofibrosis | What I Tell My Patients: Integrating New Research Information into Current Clinical Care — Myelofibrosis Jun 06, 2024

Show notes

Featuring perspectives from Ms Ilene Galinsky, Dr Andrew T Kuykendall, Dr Sara M Tinsley-Vance and Dr Abdulraheem Yacoub, including the following topics:

Introduction (0:00)
The Biology of Myelofibrosis (MF) (14:00)
Role of Available and Investigational JAK inhibitors for the Management of MF (45:49)
Promising Agents and Strategies for Patients with MF (1:23:17)

NCPD information and select publications

Ovarian Cancer | What I Tell My Patients: Integrating New Research Information into Current Clinical Care — Ovarian Cancer Jun 04, 2024

Show notes

Featuring perspectives from Ms Courtney Arn, Dr Floor J Backes, Dr Kathleen N Moore and Ms Jaclyn Shaver, including the following topics:

Introduction: The Incidence, Pathogenesis and Prognosis of Ovarian Cancer (0:00)
Genetic Testing for Newly Diagnosed Advanced Ovarian Cancer (11:01)
The Role of PARP Inhibitor Maintenance for Newly Diagnosed Advanced Ovarian Cancer (19:02)
Side Effects Associated with PARP Inhibitors (29:58)
Dosing, Adherence and Other Issues with PARP Inhibitors for Ovarian Cancer (48:29)
The Potential Role of PARP Inhibitors in Combination with Anti-PD-1/PD-L1 Antibodies for Advanced Ovarian Cancer Management (54:11)
PARP Inhibitors for Relapsed/Refractory Ovarian Cancer (1:00:36)
The Current Role of Mirvetuximab Soravtansine for Ovarian Cancer Treatment (1:07:14)
Toxicities with Mirvetuximab Soravtansine (1:11:53)
The Incidence and Management of HER2-Positive Ovarian Cancer (1:18:18)

NCPD information and select publications

Head and Neck Cancer | What I Tell My Patients: Integrating New Research Information into Current Clinical Care — Head and Neck Cancer May 31, 2024

Show notes

Featuring perspectives from Ms Meetal Dharia, Dr Robert L Ferris, Dr Robert Haddad and Ms Lynsey P Teulings, including the following topics:

Introduction (0:00)
The Biology of Head and Neck Cancer (15:41)
The Multidisciplinary Treatment of Head and Neck Cancer (18:14)
Ongoing Screening and Prevention After Potentially Curative Therapy for Head and Neck Cancer (33:03)
Radiation Therapy and Chemotherapy Side Effects (41:02)
The Potential Short- and Long-Term Effects of Surgery for Head and Neck Cancer (49:50)
Emerging Treatment Strategies Aimed at Improving Outcomes Associated with Localized or Locally Advanced Head and Neck Cancer (56:46)
Tolerability Considerations with Xevinapant (1:06:13)
The Established Role of Anti-PD-1/PD-L1 Antibodies in Therapy for Advanced Head and Neck Cancer (1:17:35)
Newly Approved Immunotherapeutic Strategies for Nasopharyngeal Carcinoma (1:19:27)
The Tolerability of Immune Checkpoint Inhibitors (1:24:09)