Research To Practice | Oncology Videos

Latest Episodes:

HR-Positive and Triple-Negative Metastatic Breast Cancer — An Interview with Dr Laura Huppert on Optimal Integration of ADCs into Treatment (Companion Faculty Lecture) Oct 13, 2025

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Featuring a slide presentation and related discussion from Dr Laura Huppert, including the following topics:

Overview of approved antibody-drug conjugates (ADCs) for metastatic hormone receptor-positive HER2-negative breast cancer — trastuzumab deruxtecan, sacituzumab govitecan and datopotamab deruxtecan(0:00)
Approved and investigational ADCs for metastatic triple-negative breast cancer (17:18)
Sequencing of ADCs for metastatic HER2-negative breast cancer; future research directions (26:10)

CME information and select publications

Follicular Lymphoma — Proceedings from a Session Held During the Society of Hematologic Oncology 2025 Annual Meeting Oct 10, 2025

Show notes

Featuring perspectives from Dr Jeremy S Abramson, Dr Jennifer Crombie and Dr Laurie H Sehn, moderated by Dr Abramson, including the following topics:

Introduction (0:00)
Integrating Bispecific Antibodies into the Management of Follicular Lymphoma (FL) — Dr Crombie (2:08)
ICurrent Role of CD19-Directed Chimeric Antigen Receptor T-Cell Therapy for FL — Dr Abramson (21:01)
Other Recently Approved and Emerging Novel Therapies for Relapsed/Refractory FL — Dr Sehn (40:52)

CE information and select publications

Acute Myeloid Leukemia — An Interview with Dr Ghayas Issa on the Role of Menin Inhibitors Oct 09, 2025

Show notes

Featuring an interview with Dr Ghayas Issa, including the following topics:

Mechanism of action and efficacy of menin inhibitors (0:00)
Presentation and management of differentiation syndrome (13:31)
Role of menin inhibitors in other cancers (18:19)
Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51)
Mechanisms of resistance to menin inhibition in AML (26:53)
Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31)
Mechanism of action of menin inhibitors as differentiation agents (38:05)
Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55)
Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25)
Other investigational therapeutic strategies in AML (54:39)

CME information and select publications

Acute Myeloid Leukemia — An Interview with Dr Ghayas Issa on the Role of Menin Inhibitors (Companion Faculty Lecture) Oct 08, 2025

Show notes

Featuring a slide presentation and related discussion from Dr Ghayas Issa, including the following topics:

Evolution of menin inhibitors for acute myeloid leukemia (AML) (0:00)
Side effects of menin inhibition (10:54)
Mechanisms of resistance to menin inhibition in AML (15:08)

CME information and select publications

Breast Cancer — An ASCO 2025 Review Oct 07, 2025

Show notes

Featuring perspectives from Dr Sara A Hurvitz and Dr Sara M Tolaney, including the following topics:

Introduction: View from Outer Space (0:00)
Hormone Receptor-Positive Breast Cancer (6:23)
HER2-Positive Breast Cancer (40:54)
Triple-Negative Breast Cancer (52:48)

CME information and select publications

Breast Cancer — An ASCO 2025 Review (Faculty Case Presentations) Oct 06, 2025

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Featuring case presentations and related discussion from Dr Sara A Hurvitz and Dr Sara M Tolaney, including the following topics:

Case: A woman in her mid 50s with localized HR-negative, HER2-positive breast cancer — Dr Tolaney (0:00)
Case: A woman in her mid 40s with localized HR-positive breast cancer with a germline BRCA2 mutation — Dr Tolaney (7:08)
Case: A woman in her early 30s with HR-negative, HER2-positive metastatic breast cancer with one isolated liver metastasis — Dr Tolaney (11:30)
Case: A woman in her early 50s with metastatic triple-negative breast cancer — Dr Tolaney (17:52)
Case: A woman in her early 30s with localized HR-positive, HER2-negative breast cancer — Dr Hurvitz (31:49)
Case: A woman in her early 60s with HR-positive, HER2-negative metastatic breast cancer with concurrent PIK3CA and ESR1 mutations — Dr Hurvitz (40:39)
Case: A woman in her early 40s with recurrent HR-positive advanced breast cancer with a PIK3CA mutation — Dr Hurvitz (51:28)
Case: A woman in her early 50s with HR-positive, HER2-negative breast cancer eligible for the SERENA-6 switching strategy — Angela DeMichele, MD, MSCE (58:41)

CME information and select publications

Relapsed/Refractory Multiple Myeloma — Proceedings from a Session Held During the Society of Hematologic Oncology 2025 Annual Meeting Oct 02, 2025

Show notes

Featuring perspectives from Prof Meletios-Athanasios (Thanos) C Dimopoulos, Dr Hans Lee, and Dr Noopur Raje, moderated by Dr Joseph Mikhael, including the following topics:

Introduction (0:00)
Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory (R/R) Multiple Myeloma (MM) — Dr Raje (3:17)
Integrating Bispecific Antibodies into the Management of R/R MM — Dr Lee (20:38)
Potential Role of Antibody-Drug Conjugates and Cereblon E3 Ligase Modulators in Therapy for MM — Prof Dimopoulos (40:37)

CE information and select publications

Breast Cancer — 5-Minute Journal Club Issue 3 with Dr Kevin Kalinsky: Defining the Role of TROP2-Directed Antibody-Drug Conjugates Sep 26, 2025

Show notes

Featuring an interview with Dr Kevin Kalinsky, including the following topics:

Patient-Reported Outcomes from the TROPION-Breast01 Study (0:00)
- Pernas S et al. Datopotamab deruxtecan (Dato-DXd) vs chemotherapy (CT) in previously treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer (BC): Patient-reported outcomes from the TROPION-Breast01 study. ASCO 2024;Abstract 1006.
Indirect Comparison of Sacituzumab Govitecan and Datopotamab Deruxtecan for Advanced Breast Cancer (5:04)
- Pathak N et al. Indirect comparison of sacituzumab govitecan (SG) and datopotamab deruxtecan (Dato-DXd) in advanced breast cancer (aBC): Safety and efficacy analysis. San Antonio Breast Cancer Symposium 2024;Abstract P1-02-02.
BEGONIA: A Phase Ib/II Study of Datopotamab Deruxtecan with Durvalumab as First-Line Treatment for Unresectable Advanced Triple-Negative Breast Cancer (9:53)
- Schmid P et al. Datopotamab deruxtecan (Dato-DXd) + durvalumab (D) as first-line (1L) treatment for unresectable locally advanced/metastatic triple-negative breast cancer (a/mTNBC): Updated results from BEGONIA, a phase Ib/II study. ESMO 2023;Abstract 379MO.
Advances in the Use of TROP2-Targeted Antibody-Drug Conjugates for Breast Cancer: Mechanisms, Clinical Applications and Future Directions (15:35)
- Tong Y et al. Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: Mechanisms, clinical applications, and future directions. Front Immunol 2024;15:1495675. Abstract

CME information and select publications

Metastatic BRCA-Negative Triple-Negative Breast Cancer — An Interview with Prof Peter Schmid on Optimal Management Sep 23, 2025

Show notes

Featuring an interview with Prof Peter Schmid, including the following topics:

Response to immunotherapy in breast cancer subtypes (0:00)
Tolerability of TROP2 antibody-drug conjugates (ADCs) for metastatic breast cancer (mBC) (3:51)
Approaches to therapy for patients with HR-negative HER2-low and HER2-ultralow mBC (13:03)
ADC structure and treatment-related adverse events (19:02)
Available data from the Phase III ASCENT-04 trial evaluating sacituzumab govitecan with pembrolizumab as first-line therapy for patients with PD-L1-positive advanced triple-negative breast cancer (23:06)
Novel ADCs and bispecific antibodies under investigation for mBC (28:30)
Comparing datopotamab deruxtecan and sacituzumab govitecan for HR-positive disease (33:01)
Clinical investigator perspectives on the Phase III DESTINY-Breast09 trial evaluating first-line trastuzumab deruxtecan with or without pertuzumab versus THP (docetaxel/rastuzumab/pertuzumab) for HER2-positive mBC (35:06)

CME information and select publications

Metastatic BRCA-Negative, Triple-Negative Breast Cancer — An Interview with Prof Peter Schmid on Optimal Management (Companion Faculty Lecture) Sep 22, 2025

Show notes

Featuring a slide presentation and related discussion from Prof Peter Schmid, including the following topics:

Evolution of the therapeutic landscape for metastatic triple-negative breast cancer; age of immunotherapy (0:00)
Case: A woman in her early 40s with no actionable mutations (7:29)
Evolution of antibody-drug conjugates (ADCs) in the management of metastatic breast cancer (11:13)
TROP2-directed ADCs (15:22)
Case: A woman in her early 50s with PD-L1-negative, HR-negative, HER2-low de novo metastatic breast cancer (20:21)
Novel strategies utilizing approved and investigational ADCs (23:28)
Case: A woman in her early 60s with loss of HER2 expression on disease progression (31:39)
ADCs in combination with immunotherapy (32:51)

CME information and select publications