Research To Practice | Oncology Videos

Latest Episodes:

Toxicities Associated with Antibody-Drug Conjugates for Metastatic Breast Cancer — Clinical Investigator Perspectives on Actual Patient Cases Dec 23, 2025

Show notes

Featuring perspectives from Dr Lisa A Carey and Dr Rita Nanda, including the following topics:

Overview: Molecular basis of antibody-drug conjugate (ADC) toxicities — Sequencing of ADCs and mechanisms of resistance (0:00)
Case: A woman in her late 60s with localized triple-negative breast cancer develops myocarditis during neoadjuvant therapy with chemotherapy/pembrolizumab — Richard Zelkowitz, MD (8:22)
Case: A woman in her mid 70s with recurrent ER-negative, HER2-low, PD-L1-positive metastatic breast cancer (mBC) who experiences disease progression on nab paclitaxel/atezolizumab responds to sacituzumab govitecan — Ranju Gupta, MD (26:43)
Case: A woman in her early 80s with recurrent ER-positive, HER2-low (IHC 1+) mBC experiences disease progression on trastuzumab deruxtecan (T-DXd), then receives datopotamab deruxtecan and develops pulmonary symptoms — Laila Agrawal, MD (32:11)
Data Review: T-DXd (37:51)
Case: A woman in her early 70s with recurrent ER-positive, HER2-low (IHC 1+) mBC, including bladder metastases, experiences disease progression after palbociclib/letrozole, then capivasertib/fulvestrant, then nab paclitaxel — Justin Favaro, MD, PhD (44:02)
Case: A woman in her late 70s with ER-positive, HER2-low mBC who experiences disease progression after 1 year of ribociclib/letrozole receives sacituzumab govitecan — Erik Rupard, MD (55:19)

CME information and select publications

Advanced Gastroesophageal Cancers — Expert Perspectives on Actual Patient Cases: Part 2 of 2 Dec 22, 2025

Show notes

Featuring perspectives from Dr Yelena Y Janjigian, including the following topics:

Introduction (0:00)
Case: A man in his early 60s with a history of Barrett's esophagus presents with HER2-positive metastatic esophageal adenocarcinoma and a PD-L1 combined positive score (CPS) of 3 — Jennifer Yannucci, MD (10:20)
Case: A man in his early 60s with multiregimen-recurrent HER2-positive gastroesophageal junction (GEJ) adenocarcinoma (claudin 18.2-positive, PD-L1 CPS 0) — Neil Morganstein, MD (14:53)
Case: A woman in her early 80s with dementia and newly diagnosed mismatch repair-deficient, PD-L1-positive metastatic GEJ adenocarcinoma — Brian P Mulherin, MD (25:55)
Case: A man in his mid 60s with localized HER2-negative GEJ cancer (PD-L1 CPS 2, claudin 18.2-positive) and residual disease after receiving neoadjuvant chemoradiation therapy and undergoing surgery — Stephen "Fred" Divers, MD (32:18)
Case: A man in his early 80s with metastatic recurrence of esophageal adenocarcinoma and a PD-L1 total proportion score of 75% 2 years after resection of localized disease — Susmitha Apuri, MD (40:28)
Case: A man in his mid 70s with claudin 18.2-positive metastatic esophageal adenocarcinoma who develops progressive toxicities with FOLFOX and zolbetuximab — Sean Warsch, MD (52:54)

CME information and select publications

Urothelial Bladder Cancer and Prostate Cancer — Highlights from the 2025 ESMO Annual Meeting Dec 19, 2025

Show notes

Featuring perspectives from Dr Terence Friedlander and Dr Rana R McKay, including the following topics:

Introduction (0:00)
Prostate Cancer (1:44)
Urothelial Bladder Cancer (29:18)

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Extensive-Stage Small Cell Lung Cancer — What Clinicians Want to Know About First-Line and Maintenance Therapy Dec 17, 2025

Show notes

Featuring perspectives from Dr Luis Paz-Ares and Dr Misty Dawn Shields, including the following topics:

Introduction: Tail on the Curve? (0:00)
First-Line Chemoimmunotherapy (10:45)
Maintenance Lurbinectedin (28:42)
Second-Line Treatment, Tarlatamab (45:35)
Ongoing Research (53:20)

CME information and select publications

Gastroesophageal Cancers — Proceedings from a Symposium Held in Partnership with the American Oncology Network Dec 13, 2025

Show notes

Featuring perspectives from Dr Manish A Shah, moderated by Dr Stephen "Fred" Divers, including the following topics:

Highlights and Principles of Management of Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma — Dr Shah (0:00)
Case: A man in his early 50s with microsatellite instability-high localized esophageal adenocarcinoma — Dr Mulherin (15:24)
Case: A woman in her late 60s with HER2-positive (IHC 3+) and HER2 TKD-mutant metastatic esophageal adenocarcinoma — Dr Warsch (25:34)
Case: A woman in her early 70s with HER2-positive (IHC 3+), PD-L1-negative, CLDN18.2-negative metastatic gastric cancer — Dr Mulherin (28:15)
Case: A woman in her early 70s with metastatic gastroesophageal junction adenocarcinoma (PD-L1 CPS 15) who begins treatment with FOLFOX/nivolumab and subsequently is found to have CLDN18.2 overexpression — Dr Lamar (35:23)
Case: A man in his mid 40s with CLDN18.2-positive metastatic esophageal adenocarcinoma (PD-L1 10%) who receives mFOLFOX6 and zolbetuximab — Dr Yannucci (42:54)

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Ovarian Cancer — Proceedings from a Symposium Held in Partnership with the American Oncology Network Dec 13, 2025

Show notes

Featuring perspectives from Dr Gottfried E Konecny, moderated by Dr Stephen "Fred" Divers, including the following topics:

Updates in Ovarian Cancer (OC) 2025 — Dr Konecny (0:00)
Case: A woman in her mid 50s with ovarian cancer and a PALB2 germline mutation — Dr Mulherin (17:15)
Case: A woman in her early 60s with Stage IVB fallopian tube carcinoma and a BRCA2 germline mutation — Dr Yannucci (26:27)
Case: A woman in her mid 60s with OC and a BRCA2 somatic mutation who develops cytopenias on maintenance olaparib — Dr Lamar (35:47)
Case: A woman in her early 70s with HER2 IHC 2+, ER-expressing, FOLR1-positive OC — Dr Warsch (42:54)

CE information and select publications

Chronic Lymphocytic Leukemia — Proceedings from a Symposium Held in Partnership with the American Oncology Network Dec 12, 2025

Show notes

Featuring perspectives from Dr Kerry Rogers, moderated by Dr Stephen "Fred" Divers, including the following topics:

Chronic Lymphocytic Leukemia (CLL) — Dr Rogers (0:00)
Case: A man in his mid 70s with CLL and a history of atrial fibrillation — Dr Lamar (13:08)
Case: A fit man in his early 80s with IGHV-unmutated, TP53-mutant symptomatic CLL — Dr Mulherin (21:16)
Case: A woman in her mid 80s with IGHV-mutated recurrent CLL who receives pirtobrutinib — Dr Warsch (32:41)
Case: A woman in her late 70s with recurrent del(17p) CLL who receives venetoclax/obinutuzumab — Dr Yannucci (44:52)

CE information and select publications

Lung Cancer — Proceedings from a Symposium Held in Partnership with the American Oncology Network Dec 12, 2025

Show notes

Featuring perspectives from Dr Justin F Gainor, Dr Corey J Langer and Dr Misty Dawn Shields, moderated by Dr Stephen "Fred" Divers, including the following topics:

Introduction (0:00)
Targeted Therapy for Non-Small Cell Lung Cancer (NSCLC) — Dr Gainor, MD (5:32)
Case: A woman in her mid 60s with ALK-mutant metastatic adenocarcinoma of the lung (PD-L1 TPS 70%) — Zanetta S Lamar, MD (17:59)
Case: A woman in her mid 80s with EGFR exon 19-deleted adenocarcinoma of the lung with recurrence after 4 years of osimertinib — Jennifer Yannucci, MD (27:53)
Case: A woman in her late 60s with HER2-mutant metastatic adenocarcinoma of the lung — Brian P Mulherin, MD (39:41)
Case: A man in his early 70s with locally recurrent squamous cell carcinoma of the lung and a MET exon 14 skipping mutation — Sean Warsch, MD (46:39)
Case: A woman in her early 70s with ROS1-mutant metastatic adenocarcinoma of the lung that responds to entrectinib and then to pembrolizumab/carboplatin/pemetrexed administered upon disease progression — Dr Yannucci (52:44)
Nontargeted Therapy for NSCLC; Small Cell Lung Cancer — Dr Langer (58:16)
Neoadjuvant, Perioperative and Adjuvant Anti-PD-1/PD-L1 Antibody-Based Approaches for Patients with Localized NSCLC — Dr Shields (1:14:14)
Case: A man in his mid 60s with localized adenocarcinoma of the lung who receives neoadjuvant cisplatin/pemetrexed/pembrolizumab and achieves a pathologic complete response — Dr Mulherin (1:23:19)
Case: A man in his early 60s with metastatic mixed adenosquamous NSCLC (PD-L1 TPS 50%) — Sunil Babu, MD (1:30:04)
Case: A man in his late 50s diagnosed with extensive-stage small cell lung cancer who receives carboplatin/etoposide/durvalumab — Dr Warsch (1:34:07)

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CAR T-Cell Therapy for Non-Hodgkin Lymphoma | Cancer Q&A — Discussing Common Questions Posed by Patients Dec 11, 2025

Show notes

Featuring perspectives from Dr Jeremy S Abramson and Dr Loretta J Nastoupil, including the following topics:

Overview of Chimeric Antigen Receptor (CAR) T-Cell Therapy (0:00)
Potential Treatment Benefits of CAR T-Cell Therapy (13:31)
Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome (28:13)
Finding Information About CAR T-Cell Therapy; Clinical Trials (36:28)
Financial Issues; Risk of Infection (42:02)
Coping with Anxiety; Healing and Moving On (53:27)

CME information and select publications

HER2-Altered Non-Small Cell Lung Cancer — An Interview with Dr John V Heymach Dec 10, 2025

Show notes

Featuring an interview with Dr John V Heymach, including the following topics:

Differentiating factors among various HER2 alterations in non-small cell lung cancer (NSCLC) (0:00)
Activity of targeted agents across HER2 alterations in NSCLC (4:06)
Available data with zongertinib and sevabertinib for HER2-mutant NSCLC (20:39)
Case: A man in his late 40s with HER2-mutant NSCLC receives multiple lines of therapy, including trastuzumab deruxtecan (T-DXd) and zongertinib (29:23)
Case: A woman in her mid 50s with HER2-mutant NSCLC receives zongertinib with durable response (34:23)
Case: A woman in her late 50s with HER2-mutant NSCLC receives multiple lines of therapy, including sevabertinib and T-DXd (39:53)
Investigational approaches in HER2-mutant NSCLC (46:31)

CME information and select publications