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    Technology

    Possible with Reid Hoffman

    What if, in the future, everything breaks humanity’s way? Possible is an award-winning, weekly podcast that sketches out the brightest version of the future—and what it will take to get there. Hosts Reid Hoffman and Aria Finger take that question to the people building the answer: founders, scientists, artists, and deep thinkers working across AI, healthcare, education, and geopolitics. The conversations run deep and specific, testing optimism against hard questions rather than trading hot takes. And between guest episodes, Reid riffs on the AI news that matters and what to make of it. 

    Advertise

    Copyright: © Reid Hoffman 2023

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    Latest Episodes:
    Sarah Longwell on politics, AI, and elections Sep 18, 2024
    Show notes

    What’s driving some of the greatest political divisions and threats to democracy ahead of the 2024 U.S. presidential election?

    This week, Reid and Aria attempt to unpack this with someone who specializes in listening to American voters and translating those insights, at scale: Republican political strategist and The Bulwark co-founder/publisher Sarah Longwell. Sarah, who also hosts The Focus Group Podcast, joins the show to talk about her experience listening to everyday voters through focus groups — and her perspective on how doing so can help people better understand one another, combat misinformation, and heal some of the deepest divides in America today. She shares her perspective on Donald Trump, the upcoming election, the state of politics in Silicon Valley, AI, the future of the Republican Party, and the value of compromising. Plus, Reid tests GPT-4o’s ability to separate fact from fiction.

    Note: This conversation is not intended to proselytize or convert anyone. Rather, it is an attempt to learn from someone who has spent hundreds of hours talking to thousands of voters about their lives and politics.

    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

    Topics:

    03:41 - Hellos and intros

    04:55 - The state of politics now

    06:08 - Inside the mind of an undecided voter

    08:22 - What polls actually tell us

    10:04 - What’s different about the political attitude right now

    12:22 - How focus groups work, and what they tell us

    18:08 - The benefits of qualitative research

    18:52 - How can technology improve focus group research?

    23:12 - How to become a better listener and persuader

    28:21 - The impact and use cases of AI running focus groups

    34:03 - When a human touch is necessary

    36:37 - AI video-based sentiment analysis

    41:05 - Sarah navigating being a lone wolf in politics

    45:19 - What Sarah learned fighting for marriage equality

    47:25 - How does misinformation spread and stick?

    54:08 - What’s next for the Republican party?

    57:42 - GPT-4o “spot the fake headline” test

    01:02:57 - Rapid-fire questions

    Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Whether it's Inflection’s Pi, OpenAI’s ChatGPT or other AI tools, each episode will use AI to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.


    Reid riffs on his personal history with AI Sep 11, 2024
    Show notes

    Reid reflects on his early exposure to AI as an undergraduate at Stanford and on navigating the space between academia and industry. Plus, he and Aria discuss human outcomes of technology—and how human-centered technologists such as Fei-Fei Li, Mustafa Suleyman, and Kevin Scott have helped him keep those outcomes top of mind.


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Daphne Koller on drug discovery and AI Sep 04, 2024
    Show notes

    How can scientists leverage AI and machine learning to more effectively research, develop, and deliver new drugs? This week, Reid and Aria talk drug development with renowned computer scientist and executive Dr. Daphne Koller, whose company, insitro, uses machine learning to improve the quality and speed of drug discovery. She addresses several ways AI and ML are already being used to redefine diseases and create better therapeutic interventions. Plus, she shares her experience transitioning from academia to industry.


    Read the transcript of this episode here: https://www.possible.fm/podcasts/dkoller


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Topics:

    00:01: Cold open

    00:43: Hellos and intros

    3:20: Early involvement in AI

    5:00: Overview of drug discovery and its evolution over the last five years

    7:50: AI and machine learning impact on biology and drug development

    9:09: Pi aside defining AlphaFold

    11:37: Areas of acceleration and opportunity in AI and drug discovery

    17:21: Synthetic data

    21:21: AI implications on therapeutic hypotheses

    23:54: Personalized vs. precision medicine

    27:04: Closing the data feedback loop

    30:31: Exciting announcements

    34:24: Privacy and data

    36:41: GPT-4 story

    38:48: Stuart Russell’s comments on the applications of Koller’s thesis

    43:36: AI as a moving target

    47:24: How can academia and industry positively impact society and humanity

    51:58: insitro’s culture

    54:18: - Rapid-fire questions


    Select mentions:

    Not the End of the World: How We Can Be the First Generation to build a Sustainable Planet by Hannah Ritchie


    Stuart Russell



    Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Whether it's Inflection’s Pi, OpenAI’s ChatGPT or other AI tools, each episode will use AI to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.


    Reid riffs on the future of human connectivity Aug 28, 2024
    Show notes

    This week, Reid veers toward science fiction, tackling big questions including: Is a single mentally-linked network in our future? Can and should humans create other sentient beings?


    Select mentions:

    David Brin


    Nick Thompson on our AI future Aug 21, 2024
    Show notes

    What might it look like if we used AI to make democracy work better and to make society more equal? In this special live recording of Possible, Aria turns the tables on her co-host, interviewing Reid alongside Atlantic CEO Nick Thompson. They discuss AI-native generations, the future of friendship and social connections, media, data, privacy, and democracy in the age of AI. To kick off the episode, Reid’s avatar makes a cameo.


    Read the transcript of this episode here: https://www.possible.fm/podcasts/nthompson


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Topics:

    1:53 - Hellos and intros

    2:15 - A question from Reid’s AI Avatar

    6:24 - Defining this moment in technology

    10:08 - AI, journalism, and democracy

    13:32 - AI and empathy

    20:17 - Why AI is exciting for young people

    22:44 - How impacts the world of friendship

    33:07 - AI and privacy

    41:21 - Looking ahead

    47:51 - Rapid-fire questions


    Select mentions:

    The Worlds I See by Fei-fei Li


    Earth Species Project


    Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Whether it's Inflection’s Pi, OpenAI’s ChatGPT or other AI tools, each episode will use AI to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.


    Reid riffs on AI regulation Aug 14, 2024
    Show notes

    This week, Aria asks Reid about government regulation of AI, including where the U.S. fits in on the global stage and how America can learn from where the early regulation of social media fell short.


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Gina Raimondo on AI, government, and commerce Aug 07, 2024
    Show notes

    How can the U.S. government support the use of AI to stimulate innovation, bring healthcare to people more effectively, and educate people more equitably—all while thoughtfully navigating technology’s impact on people’s way of life?


    On this week’s episode, Reid and Aria sit down with U.S. Secretary of Commerce Gina Raimondo to discuss her work leading the government’s efforts to minimize the risks and maximize the benefits of AI for Americans. She gets into the federal government’s approach to AI innovation and safety, emphasizing the importance of global partnerships. Plus, she shares how the U.S. can make hardware “sexy” again—and why it matters.


    Read the transcript of this episode here: https://www.possible.fm/podcasts/raimondo


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Topics:

    3:30 - Hellos and intros

    6:44 - Hopes and goals for American citizens

    9:34 - America’s approach to AI compared to its approach to other digital innovations

    14:15 - How the U.S. can “make building hardware sexy again”

    18:21 - International cooperation on AI

    21:39 - How technology leaders can contribute to private-public partnerships

    24:14 - What excites Secretary Raimondo most right now

    26:35 - How industry can relieve anxiety about job security in an AI-world


    Select mentions:

    AI Safety Institute


    CHIPS Act


    Regional Technology and Innovation Hubs (Tech Hubs)


    Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Whether it's Inflection’s Pi, OpenAI’s ChatGPT or other AI tools, each episode will use AI to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.


    Reid riffs on AI agents and investments Jul 31, 2024
    Show notes

    In this episode, Aria asks Reid about his general and AI-specific investment philosophies, including what draws him to a pitch and what raises red flags. They discuss agentic AI, robots, and hardware.


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Ashton Kutcher on AI and investing Jul 24, 2024
    Show notes

    This week, Reid and Aria are joined by Ashton Kutcher. While you might know him as the actor and producer who rose to fame on That ‘70s Show, Dude, Where’s My Car, and MTV’s Punk’d, Ashton is also an accomplished venture capitalist. He is co-founder of the VC firm Sound Ventures, and he has been investing in AI for more than a decade. Ashton, Reid, and Aria discuss the future of AI software and hardware, startups, and the AI revolution’s impact on society.


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


    Topics:

    3:00 - Hellos and intros

    3:56 - Ashton and Reid’s trip to the South Pole

    8:20 - What’s exciting about AI for investors

    13:31 - How Ashton brings AI into his daily life

    19:02 - Changes to the job market in an age of AI

    22:01 - How people can maintain their agency and find more time in the age of AI

    26:37 - AI and talent-sourcing

    30:40 - How to be a “tryer”

    35:14 - Rapid-fire questions


    Select mentions


    The Anxious Generationby Jonathan Haidt


    Dædalus

    Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Whether it's Inflection’s Pi, OpenAI’s ChatGPT or other AI tools, each episode will use AI to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.


    Reid riffs on building better cities Jul 17, 2024
    Show notes

    Reid discusses what aspects of urban planning need to be reimagined. He advocates that prioritizing smart technology, clean energy, and data can vastly improve residents’ quality of life. Plus, Aria asks Reid about the potential of technologies existent and forthcoming—including self-flying cars.


    For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/


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