PeerView Neuroscience & Psychiatry CME/CNE/CPE Audio Podcast

Latest Episodes:

Anna Chodos, MD, MPH - Facilitating Cognitive Assessment in Primary Care for the Timely Detection of Alzheimer’s Disease: Leveraging Medicare Reimbursement Mechanisms to Improve Clinical Care Jun 01, 2023

Show notes

Go online to PeerView.com/XUM860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. The timely detection and diagnosis of Alzheimer’s disease (AD) can provide patients with numerous opportunities—earlier treatment initiation, increased eligibility for clinical trials, participation in long-term care planning, and the chance to make lifestyle changes to slow cognitive decline. In this activity, based on a recent live symposium, experts discuss practical strategies for integrating cognitive screening into routine care visits and conducting more detailed cognitive evaluations that results in a written care plan with patients who fail a brief cognitive screening assessment. Experts also share guidance on working with Medicare reimbursement mechanisms to facilitate consistent and effective use of early detection tools and practical skills to counsel patients and their caregivers before, during, and after the diagnostic process. Upon completion of this activity, participants should be better able to: Integrate routine cognitive assessment in outpatient visits of older adults who present with signs and symptoms of cognitive impairment to facilitate the timely diagnosis of MCI and mild dementia due to AD; Employ appropriate tools for documentation and coding of procedures (eg, cognitive assessments) and services for patients presenting with cognitive symptoms or concerns; and Implement effective communication strategies to educate patients and caregivers about the clinical significance and prognostic implications of their cognitive assessment results

Daniel S. Reich, MD, PhD - Targeting BTK: The Latest Data on the Evolving Treatment Landscape for Patients With MS Jun 01, 2023

Show notes

Go online to PeerView.com/TFV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this video, an expert reviews new data on the potential role of BTK inhibitors in the treatment of patients with multiple sclerosis presented at the American Academy of Neurology 2023 annual meeting. Learn how BTK inhibitors compare with anti-CD20 monoclonal antibodies and why this emerging class of DMTs may present a safe, effective, and highly selective treatment option with a low risk of opportunistic infections and possibly the ability to cross the blood–brain barrier, with results that may include a meaningful effect on proinflammatory cells in the CNS and the potential to prevent disability progression. Upon completion of this activity, participants should be better able to: Discuss the mechanism of action of Bruton tyrosine kinase (BTK) inhibitors in the targeted treatment of MS; Assess the current evidence regarding the efficacy, safety, and tolerability of BTK inhibitors for the treatment of MS; and Identify patients who may benefit from treatment with BTK inhibitors, based on current evidence and individual treatment needs and priorities

Vera Bril, BSc, FRCPC, MD - Leveraging FcRn Modulation in Personalized Management of Generalized Myasthenia Gravis: Applying the Evidence, Tools, and Patient Perspectives to Achieve Treatment Goals Jun 01, 2023

Show notes

Go online to PeerView.com/EZC860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. An international panel of experts discusses the data on clinical outcomes, safety, and efficacy of new and emerging therapies for the treatment of myasthenia gravis. The interdisciplinary discussion focuses on FcRn modulation and personalized treatment approaches, and includes an interview with a patient who discusses her life and treatment journey with myasthenia gravis. Upon completion of this activity, participants should be better able to: Integrate new and emerging gMG-targeted therapies into treatment plans as appropriate, based on an understanding of the data on clinical outcomes, safety, and effects on quality of life; Develop a management strategy that incorporates the patient’s perspective in identifying treatment goals and choices; and Implement a safe, individualized administration protocol for the management of gMG that responds to clinical and patient-reported outcomes measures of treatment response and adverse events

Robert C. Green, MD, MPH - Revisiting the Role of Genetic Testing in Patients at Risk for Late-Onset Alzheimer’s Disease: How Will the Latest Evidence and Evolving Management Paradigm Impact Treatment Decisions for Your Patients? Apr 06, 2023

Show notes

Go online to PeerView.com/AQF860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Late-onset Alzheimer’s disease (LOAD) has a substantial genetic component, with heritability estimated to be between 40% and 80%, and the APOE ε4 allele is the strongest individual genetic risk factor for LOAD. Until recently, the APOE genotype test has been primarily used as a research tool and not recommended for clinical use. However, with the recent advances in disease-modifying therapies (DMTs), including several anti–amyloid monoclonal antibodies approved or in late-stage development, it is more important to determine which patients have the APOE ε4 allele and whether these patients are at an elevated risk of developing amyloid-related imaging abnormalities (ARIA). In this activity, based on a recent live webcast, experts examine the significance of APOE ε4 carrier status on the risk for developing LOAD, as well as the potential implications for patient care, including the increased risk for ARIA in patients taking anti-amyloid monoclonal antibodies. They provide guidance on identifying patients who may be candidates for genetic risk testing and share their best practices for interpreting and disclosing APOE test results and providing appropriate genetic counseling to patients and their families. Upon completion of this activity, participants should be better able to: Recognize the significance of APOE ε4 carrier status on the risk for late-onset Alzheimer's disease (LOAD) and the potential implications for patient care; Identify patients who may be candidates for genetic risk testing, and provide guidance on the benefits and limitations of direct-to-consumer testing versus genetic testing that is performed in a healthcare setting; and Interpret and share genetic risk test results with patients and their families in a clear, understandable manner, and tailor genetic counseling services to individual patients’ needs in consultation with other members of the healthcare team.

John Ravits, MD, FAAN - Hope Is on the Horizon for Patients With ALS: Overcoming Diagnostic Difficulties and Exploring Novel Emerging Therapeutic Approaches Apr 06, 2023

Show notes

Go online to PeerView.com/ZXV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert discusses the importance of early detection and diagnosis of ALS, advances in genetic testing and biomarker development, and current and emerging therapeutic approaches for patients with ALS, as well as the benefits of employing a multidisciplinary approach in managing patients with ALS. Upon completion of this activity, participants should be better able to: Identify common genes and cellular processes implicated in ALS pathogenesis; Apply established criteria to detect and diagnose patients with ALS early in the disease course; Assess key data sets on contemporary and emerging evidence-based treatment options to manage symptoms and improve the quality of life of patients with ALS; and Employ a multidisciplinary team-based approach to optimize the management of ALS based on the individual needs and preferences of each patient.

Benjamin M. Greenberg, MD, MHS / Jiwon Oh, MD, PhD, FRCPC - BTK Inhibition as an MS Treatment Modality: Where Do We Stand and Where Are We Headed? Mar 28, 2023

Show notes

Go online to PeerView.com/YCW860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. An evolving understanding of the role of B cells in pathophysiology of multiple sclerosis (MS) and the demonstrated success of other B cell–targeted therapies have led to great interest in the promise of Bruton tyrosine kinase (BTK) inhibitors as a novel MS treatment class. Compared with anti-CD20 monoclonal antibodies, BTK inhibitors are understood to offer the promise of greater selectivity that leaves healthy B cells intact, as well as the ability to cross the blood–brain barrier and affect both the peripheral and central nervous systems. Four BTK inhibitors are now in phase 3 trials, with others in earlier stages of investigation. In this activity, based on a recent live symposium, expert speakers review the pathophysiologic rationale for BTK inhibition and discuss the emerging trial data on these agents. Upon completion of this activity, participants should be better able to: Explain the pathophysiologic rationale for Bruton tyrosine kinase (BTK) inhibition in multiple sclerosis (MS) management; Assess emerging evidence on the efficacy, safety, and tolerability of BTK inhibitors being studied for the treatment of MS; and Identify patients who may benefit by treatment with BTK inhibitors, based on current evidence and individual treatment needs and priorities

Marwan Sabbagh, MD, FAAN - Gearing Up for Plasma Biomarkers in the Clinic: Real-World Strategies to Facilitate the Timely and Accurate Neuropathological Diagnosis of Alzheimer’s Disease Mar 01, 2023

Show notes

Go online to PeerView.com/DEC860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Alzheimer’s disease (AD) is a devastating yet highly prevalent condition, affecting 10% of people aged 65 years and older and increasing in prevalence as the population ages. Recent advances in disease-modifying therapies have allowed for the possibility of reductions in disease progression and improved patient outcomes. Significant advances have also been made in identifying and testing biomarkers for AD that may aid in the early diagnosis of disease, facilitate patient selection for treatment, and monitor therapeutic response. In this activity, based on a recent live event, a panel of expert faculty provide training in the appropriate integration of validated and emerging cerebrospinal fluid (CSF) and plasma biomarkers into the AD diagnostic workup to identify early-stage AD in symptomatic patients. The faculty utilize a case-based approach to model the application and interpretation of fluid biomarkers in clinical practice, as well as highlight advantages and limitations associated with currently available and emerging CSF and plasma biomarkers. Upon completion of this activity, participants should be better able to: Apply validated fluid biomarkers to facilitate a timely neuropathological diagnosis of AD in symptomatic patients; Describe the limitations and advantages associated with currently available and emerging fluid diagnostics; and Integrate emerging plasma biomarkers into the diagnostic workup through appropriate application and accurate interpretation to improve early diagnosis and precision management of AD

Val J. Lowe, MD - Revealing the Neuropathology of Alzheimer’s Disease Through Novel Fluid and Imaging Biomarkers: Ushering in a Precision Era of Diagnosis and Treatment Jan 12, 2023

Show notes

Go online to PeerView.com/UHK860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Early detection and diagnosis of Alzheimer’s disease (AD) can give patients more control over their health and future and can lead to improved outcomes. Significant advances have been made in the development of neuroimaging biomarkers, including amyloid PET and tau PET, that may aid in the early diagnosis of AD, facilitate patient selection for treatment, and monitor therapeutic response. With the anticipated growth in patients with AD around the globe and evolving developments in AD assessment and treatment, radiologists and nuclear medicine physicians are poised to play an increasingly vital role throughout AD management. In this activity, based on a recent live symposium, a panel of expert faculty discusses the importance of a timely and accurate diagnosis of AD, as well as recent research related to the evolving and complementary role of neuroimaging and fluid biomarkers in the early diagnosis and ongoing management of AD. Upon completion of this activity, participants should be better able to: Recognize the importance of making a timely and accurate neuropathological diagnosis of AD; Apply current and emerging diagnostic tools to optimize the neuropathological diagnosis of AD early in the disease course; and Identify the advantages and limitations associated with PET, cerebrospinal fluid (CSF), and plasma biomarkers

James F. Howard Jr., MD - Identifying Myasthenia Gravis and Assessing Patients’ Response to Treatment to Improve Outcomes Jan 12, 2023

Show notes

Go online to PeerView.com/PAF860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Myasthenia gravis (MG) is a rare, chronic autoimmune disorder that is highly variable in clinical presentation and treatment response. Conventional treatments (eg, corticosteroids, azathioprine, cyclosporine) are broadly immunosuppressive, do not target pathogenic IgG autoantibodies, often provide insufficient symptom relief, and are associated with significant side effects, leaving patients with substantial disease and treatment burden. Fortunately, advances in the understanding of MG pathogenesis are leading to the development of new therapeutics such as Fc receptor modulators and complement inhibitors that more selectively address the underlying disease process. Test your knowledge on this rare disease through this question-based activity. Upon completion of this activity, participants should be better able to: Recognize the range of signs and symptoms associated with myasthenia gravis (MG) to expedite an accurate diagnosis; Identify patients whose MG is not adequately controlled on their current treatment regimen; and Explain why and how to implement use of Myasthenia Gravis Activities of Daily Life (MG-ADL) in clinical care

David G. Warnock, MD - The Future Looks Bright for People With Fabry Disease: Improving Diagnosis and Expanding Treatment Options Dec 19, 2022

Show notes

Go online to PeerView.com/ZTU860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert will review the pathophysiology and clinical heterogeneity of Fabry disease. With an emphasis on accurate, early diagnosis and timely treatment, the activity will test learners’ knowledge about current and emerging therapeutic options for patients with Fabry disease. Upon completion of this activity, participants should be better able to: Recognize the pathophysiology, signs and symptoms, clinical manifestations, and consequences of FD; Apply evidence-based tools, technologies, and strategies to diagnose individuals with FD in a timely manner; and Integrate current and emerging options into the treatment regimens, as appropriate, for patients with FD, taking into account the latest efficacy and safety data from recent clinical trials.

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