PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast

Latest Episodes:

Milind Desai, MD, MBA - Pushing Back Against HCM: Can Cardiac Myosin Inhibitors Alter the Disease Progression and Management Trajectory for Patients With Hypertrophic Cardiomyopathy? Nov 08, 2022

Show notes

Go online to PeerView.com/KST860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. How are you pushing back against HCM in your practice? In PeerView’s latest CME/MOC/NCPD/CPE-certified activity, a panel of experts will present a MasterClass and Practicum on integrating cardiac myosin inhibitors into clinical practice. Learn how to apply the latest guidelines and sharpen your diagnostic skills to identify patients with HCM while hearing the latest recommendations for the individualized management of patients with obstructive HCM, including team-based collaboration. This activity also looks to the future and reviews the latest evidence for using cardiac myosin inhibitors in nonobstructive disease. Upon completion of this activity, participants should be better able to: Identify the mechanism of action of cardiac myosin inhibitors in the treatment of patients with HCM; Apply the latest recommendations and evidence-based guidance to diagnose and manage patients with HCM in a collaborative, team-based manner; Describe the efficacy and safety of cardiac myosin inhibitors, including the ability to reduce eligibility for septal reduction therapy, to address unmet needs among patients with obstructive and non-obstructive HCM; and Collaborate with patients and clinical colleagues to better identify patients with HCM and achieve their personal goals and desired outcomes pertaining to HCM management.

James F. Howard Jr., MD - A Targeted Approach to Management of Generalized Myasthenia Gravis: The Latest on Novel Therapies That Improve Patient Outcomes Nov 03, 2022

Show notes

Go online to PeerView.com/VZG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Generalized myasthenia gravis (gMG) is a rare, chronic autoimmune disorder that is highly variable in clinical presentation and treatment response. Traditionally used treatments for gMG are broadly immunosuppressive, do not target pathogenic immunoglobulin G (IgG) autoantibodies, and provide insufficient symptom relief with significant side effects. Fortunately, advances in the understanding of gMG pathogenesis are leading to the development of new treatment options, including neonatal Fc receptor (FcRn) modulators such as the recently approved efgartigimod, and rozanolixizumab, which recently completed phase 3 trials. As with all new and emerging therapeutics, it is important for clinicians to remain abreast of the latest data. At a recent live event, a multidisciplinary panel of experts compared the safety, efficacy, and tolerability of new treatment options with traditional therapies for gMG. Audience members received expert advice from the perspective of a neurologist, pharmacist, and infusion nurse, with the goal of providing their patients with individualized care through FcRn modulation therapy. Upon completion of this activity, participants should be better able to: Compare safety, efficacy, and tolerability of new treatment options with traditional therapies for generalized myasthenia gravis (gMG); Apply an understanding of the rationale and mechanisms for reducing levels of autoreactive IgG antibodies using FcRn-modulating therapies when making gMG treatment decisions; and Implement a safe administration protocol for the use of FcRn-modulating therapy that includes infusion procedures, premedications, vaccinations, and treatment cycle timing.

Mark W. Stolar, MD - A Call to Action for Primary Care Professionals: Your Role in Saving the Eyesight of Patients With Diabetes Nov 02, 2022

Show notes

Go online to PeerView.com/FZP860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Timely screenings and referrals to eye care specialists for diabetic retinopathy (DR) and diabetic macular edema (DME) can make a real difference between good vision and blindness in patients with diabetes. But exactly when should patients with diabetes be screened for DR/DME in the primary care setting and which signs and symptoms should trigger a referral to specialty care? In this activity, based on a recent live virtual symposium, leading experts review guideline recommendations for DR/DME screening and referral in the primary care setting and present realistic patient cases to explore best practices and improve vision outcomes for patients with diabetes. Upon completion of this activity, participants should be better able to: Describe the roles of primary care professionals in the screening and referral process for DR/DME and other diabetic eye diseases; Coordinate timely and appropriate referral to eye care specialists who can utilize effective treatment regimens for DR/DME and other diabetic eye diseases; and Incorporate interprofessional and multidisciplinary strategies to overcome barriers to referral using an integrated system of care approach for screening, diagnosis, and treatment of vision-threatening diabetic eye complications such as DR/DME.

Taofeek K. Owonikoko, MD, PhD - Improving Outcomes in SCLC Through Optimal Integration of the Latest Therapies: Expert Perspectives on the State of the Science, Best Practices, Multidisciplinary Care, and Future Directions Oct 28, 2022

Show notes

Go online to PeerView.com/XXU860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Recently validated and emerging therapies are providing new hope for patients with small cell lung cancer (SCLC). In patients with extensive-stage or metastatic disease, regulatory approvals of chemo-immunotherapy combinations, the transcription inhibitor lurbinectedin, and the myeloprotective agent trilaciclib have led to new guideline-recommended standards of care. Further progress is expected as ongoing clinical trials are evaluating existing therapies in different settings, including in earlier stages of disease and in various combinations, as well as promising novel therapies and rational combinations employing different agent classes and mechanisms of action. Bringing these treatment advances to the clinic comes with unique challenges, from sifting through data to ensure that patients benefit from these treatment advances and determining which patients are eligible for clinical trial enrollment to collaborating with the multidisciplinary team to manage unique adverse events associated with novel treatments and counseling patients. In this PeerView Candid Conversations & Clinical Consults program, leading experts will provide oncology specialists and multidisciplinary professionals who treat patients with lung cancer with the information they need to navigate the evidence on current and emerging therapies for SCLC. With illustrative cases serving as the cornerstone of the discussion, this activity will go beyond the basics of treatment and provide an intimate look at how top lung cancer specialists bring therapeutic advances into their own practices and what they think the future will bring. Learn about new data, guideline recommendations, and strategies to improve multidisciplinary collaboration and care; increase shared decision-making; and promote health equity in SCLC clinical care and research. Upon completion of this activity, participants should be better able to: Cite the latest evidence on available and emerging therapeutics in SCLC, including immunotherapy, transcription inhibitors, myeloprotective therapies, and other strategies, as well as emerging prospects in biomarker testing and subtyping that may help inform selection of patients for different therapies; Incorporate new and emerging therapies into individualized treatment plans for eligible patients with SCLC in clinical practice or clinical trials based on the latest evidence, guidelines, and patient needs, values, and preferences; Utilize best practices for diagnosing and managing treatment-related toxicity in patients with SCLC Implement multidisciplinary strategies and shared decision-making to ensure early diagnosis, individualized treatment, optimal management, and equitable care of patients with SCLC

Sagar Lonial, MD, FACP - An "Off-the-Shelf" Approach for Myeloma Care: Visualizing the Present and Future of BCMA Antibodies Oct 28, 2022

Show notes

Go online to PeerView.com/EGA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you ready to integrate novel "off-the-shelf" BCMA-directed antibody-based therapies into the treatment of patients with multiple myeloma (MM)? This highly visual educational activity illustrates the mechanism of action for targeting BCMA in relapsed/refractory MM (RRMM) and brings to life the latest data on the use of antibody–drug conjugates (ADCs) and emerging bispecific T-cell engagers, along with team-based strategies for safely integrating these agents into treatment plans for older, triple-class refractory, and other challenging patients. Don't miss this opportunity to learn why these customizable and convenient agents are part of the revolution in care for MM. Upon completion of this activity, participants should be better able to: State the rationale for and current evidence supporting the use of BCMA-targeting options in RRMM, including triple-class–refractory disease; Create sequential, evidence-based treatment plans that integrate novel antibody options for management of patients with RRMM; Utilize proven tools and cross-disciplinary teamwork to manage the unique safety considerations associated with BCMA-directed antibodies, including ocular toxicity, CRS, and neurotoxicity, among others

Sagar Lonial, MD, FACP - Progress on the Path to Better Outcomes in RRMM: Expert Perspectives on the Further Integration of BCMA-Directed Antibodies and Cellular Therapies Oct 28, 2022

Show notes

Go online to PeerView.com/FMJ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This “MasterClass & Case Forum” program utilizes a linked foundational lecture and case-based approach to highlight recent advances with B-cell maturation antigen (BCMA)–targeted therapies and illustrate their effects on outcomes in relapsed/refractory multiple myeloma (RRMM). Each case-centered session includes an assessment of the relevant evidence supporting the use of BCMA-directed antibodies and CAR-T therapy. Expert-led, case-based instruction on patient assessment, therapy selection, dosing and scheduling, and management of unique treatment-related AEs is built on this foundation. Watch today to earn credit! Upon completion of this activity, participants should be better able to: Summarize the latest evidence supporting the treatment roles of novel BCMA-targeting platforms, including ADCs, bispecifics, and CAR-T therapy, in relapsed/refractory disease; Develop evidence-based regimens with novel BCMA/ADCs, bispecifics, and cellular approaches that are informed by factors such as patient preference, disease prognosis, and functional status, among others; Manage practical aspects of BCMA-targeted therapy, including appropriate dosing/scheduling; patient counseling; and unique safety considerations, such as cytopenias, infusion-related events, ocular toxicity, and CRS, among others

Nicole Lamanna, MD / Deborah M. Stephens, DO - Challenges and Changes With Targeted Options in CLL: Guidance on Making Evidence-Informed Upfront and Sequential Treatment Choices Oct 28, 2022

Show notes

Go online to PeerView.com/XPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Have you caught up with therapeutic changes in chronic lymphocytic leukemia (CLL) and the latest science supporting new standards of care centered on continuous or fixed-duration therapy with targeted agents (including BTK and BCL-2 inhibitors)? In this PeerView MasterClass & Case Forum recorded at the 2022 SOHO Annual Meeting, experts give insights on how to apply this evidence and select highly personalized targeted strategies (focused on covalent and noncovalent BTK and BCL-2 inhibitor agents), when managing diverse patient populations. Watch the experts tackle challenging cases and learn strategies for selecting upfront therapy and planning sequential care in relapsed/refractory CLL. Take the challenge, see how treatment has changed, and tune in today! Upon completion of this activity, participants should be better able to: Cite updated guidelines and evidence supporting the integration of targeted drug classes in CLL, including continuous therapy, fixed-duration options, and novel combinatorial regimens; Select personalized treatment with targeted agents, including fixed-duration or continuous therapy strategies, or appropriate combinational or sequential options for patients presenting with treatment-naïve or R/R CLL; Manage treatment-emergent adverse events associated with the use of targeted agents in the CLL setting, including single-agent and combination approaches

Prof. Arjan Bredenoord - The Latest on New Options for Eosinophilic Esophagitis: Considering Targeted Biologic Therapy Oct 28, 2022

Show notes

Go online to PeerView.com/RFY860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. What’s new in the treatment of eosinophilic esophagitis (EoE)? Hear what was presented at the 30th United European Gastroenterology Week (UEG Week 2022) from Professor Arjan Bredenoord as he shares the latest evidence on novel biologic therapies for EoE and provides practical guidance on their safe and effective integration into clinical practice. Upon completion of this activity, participants should be better able to: Summarize recent clinical research data and treatment guidelines concerning the management of eosinophilic esophagitis (EoE); Integrate the latest clinical evidence concerning novel and emerging targeted therapies into treatment plans for the management of patients with EoE

Praneetha Thulasi, MD, Jonathan L. Kaufman, MD - The Eye-Deal Connection in Multiple Myeloma: Establishing Ophthalmology-Oncology Relationships to Overcome Ocular Toxicity Oct 28, 2022

Show notes

Go online to PeerView.com/AHH860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you ready to care for your patients with multiple myeloma (MM) who are experiencing ocular complications associated with the latest myeloma treatments? Ophthalmologists play an important in the care of myeloma, and in this PeerView MasterClass & Ophthalmology Case Forum an ophthalmologist and an oncologist highlight the importance of the ophthalmology and oncology connection in myeloma care. Tune in to get practical guidance on the challenges of accurately recognizing and characterizing ocular toxicity in MM patients receiving novel therapy and case-based guidance on collaborating within a modern MM management team, and see how addressing ocular toxicity can contribute to the delivery of highly effective treatment. Upon completion of this activity, participants should be better able to: Recognize the range of novel, therapy-associated ocular complications in the multiple myeloma treatment setting; Integrate proven techniques, including scheduled and routine eye examinations, dry eye prophylaxis, and therapeutic dose adjustment to address ocular toxicity in patients with multiple myeloma; Work collaboratively within oncology-ophthalmology teams to effectively monitor and manage treatment-emergent ocular toxicity in multiple myeloma patients

Scott T. Tagawa, MD, MS, FACP - Clinical Conundrums in Pretreated Metastatic Urothelial Carcinoma: Improving Patient Outcomes With Novel Antibody-Drug Conjugates Oct 28, 2022

Show notes

Go online to PeerView.com/VRE860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Metastatic urothelial carcinoma (UC) is a devastating illness with limited treatment options, especially for patients who have been previously treated with platinum-based chemotherapy and anti–PD-1/L1 therapy. This educational activity features two experts in a lively discussion about this rapidly evolving treatment landscape. The activity also features a patient and his caregiver’s perspective on their first-hand experience with the treatment strategies and his journey. These experts review the latest data and ongoing research on platinum-based chemotherapy, antibody–drug conjugates, and pan-FGFR inhibitors for the treatment of bladder cancer and discuss the management of adverse events associated with novel therapeutics. Upon completion of this activity, participants should be better able to: Integrate novel antibody-drug conjugates (ADCs) into individualized management plans for appropriate patients with metastatic UC, taking into consideration treatment history, latest clinical evidence, and current guideline recommendations; Implement team-based strategies to monitor for and manage treatment-related adverse events that may occur in patients with metastatic UC who are receiving novel ADCs as part of their care; Apply an interprofessional team-based approach to care for patients with metastatic UC that incorporates shared decision-making, appropriate patient education and counseling, and effective interprofessional collaboration and care coordination