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Scott Kupor's New Plan to Bring Tech Workers Into the Federal Government Dec 25, 2025

Show notes

If you're a high-skilled tech worker, then potentially huge fortunes await you working for a startup or one of our booming AI giants. But the government needs these types of workers too. And the government is not set up to pay commensurate salaries with the private sector -- particularly for these types of roles. This challenge has long been understood, and there have been numerous efforts over the years to infuse the government with high-tech talent. Scott Kupor is the director of the US Office of Personnel Management, which manages and coordinates recruiting of new government employees across the federal workforce. Scott was also previously one of the top partners at the famed VC firm Andreessen Horowitz. So he has a mind for bringing the recruiting practices of the tech world into DC. But of course, that's easier said than done. On this episode, we talk about how federal hiring works and doesn't work, and also his new endeavor called the US Tech Force, which aims to bring in top talent for a two-year stint of solving problems across the bureaus. We also talk about the DOGE initiative, and how he thinks about recruiting top talent at a time when the administration has been aggressive about shrinking the size of the overall federal workforce.
Read More: Federal Workforce’s Toll After a Year of DOGE and Trump: 317,000
USDA Lost a Third of DC Staff Even Before Relocation Effort
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Why Americans Are Falling Behind on Auto Loans At Their Highest Level Ever Dec 22, 2025

Show notes

By and large, American households are in a healthy economic position. Yes, unemployment has been rising, but it's still at fairly low levels. Consumer spending has held up well despite terrible sentiment. And many households are sitting on huge stock market gains and have a big home equity cushion. And yet, there are signs of trouble. Most notably, auto loan delinquencies have been surging to their highest level in history. It's the same with student loans, where delinquencies are far higher than normal. So what's going on? On this episode, we speak with Rikard Bandebo, the chief economist at VantageScore, which offers a consumer credit score that's different from the traditional FICO measures. He explains how surging prices, rising interests, and -- crucially -- rising insurance costs have created an auto squeeze. We also discuss what this means for broader consumer health and whether this auto delinquency phenomenon signals something broader about consumer stress.

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The Booming Business of Chinese Peptides Dec 19, 2025

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You probably already know someone doing peptides — the amino acids that form the basis of popular new drug treatments like Ozempic and Wegovy. Today there are peptides meant to help with everything from weight loss, to cellular regeneration, to improved eye contact while talking. In San Francisco, there are even organized “peptide raves.” Yet most of these underground peptides haven’t been approved by regulators for human use in the US. So where are they coming from? And how do they get here? On this episode, we speak with two guests who have seen this growing subculture up close, Jasmine Sun, an independent writer covering AI and San Francisco culture, as well as Zak David, managing partner of Pirsek Technologies, which runs a peptide supplier, Peptide Partners.

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Meet the Politician the AI Industry Is Trying to Stop Dec 18, 2025

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The politics of AI are already exploding. Whether we're talking about data centers, electricity prices, labor displacement, water consumption, competition with China, or users of chatbots becoming psychotically obsessed, AI is already a major topic in elections. And since there's so much money at stake, the industry is already spinning up super PACs and lobbying arms. Last month, it was reported that a new $100 million AI-industry super PAC called Leading the Future would be directly targeting Alex Bores, a Democrat who is running for his party's nomination for New York's 12th congressional district. Why target Bores? Well, as an New York assemblymember, he has led the push for the regulation of AI at the state level. The industry, of course, views state-level regulation as an existential threat to their business. So on this episode we speak with Alex about how he views AI and the optimal approach to regulation. Alex also has a tech background, and so we talk about the technology more broadly, as well as other issues in contemporary politics.
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MeatEater's Steven Rinella on the Economic History of Hunting Dec 15, 2025

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When we think about America’s economic rise, we usually point to agriculture or the industrial revolution. But in the early days of colonization, one of the biggest economic drivers wasn’t crops or factories — it was animal products. Deerskins were a booming trade that pushed hunters into new frontiers. In the early 1800s, beaver pelts became a fashion craze. And of course, later that century, we nearly hunted buffalo to extinction in another frenzy of resource extraction. On this episode, we talk to Steven Rinella, author and founder of MeatEater, about this overlooked chapter in US economic history, plus how the hunting economy functions today.

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D.A. Wallach Explains Why Biotech VC Is So Different Dec 12, 2025

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Most people think of venture capital as funding software startups or, these days, some new AI tool. But VC also plays a major role in developing new medicines and treatments. That’s the world of D.A. Wallach — though he didn’t start there. Before becoming a biotech investor, Wallach was the lead singer of the indie rock band Chester French. So how did he make the leap from music to venture capital? How does he spot promising biotech opportunities? What does it actually take to bring a new drug to market? And how does biotech investing differ from traditional VC? We talk to the co-founder of Time BioVentures about all of this — plus we get his thoughts on AI’s impact on music and a special performance.
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Read More:
Big Pharma’s Patent Cliff Puts China Front and Center
Novartis Strikes Deal With UK Biotech for Up To $1.7 Billion
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This Is What It Takes to Get a Data Center Financed Dec 11, 2025

Show notes

Data centers are weird things. They're partly real estate assets. They're partly extremely advanced technological products. And they have to find a way to consume a tremendous amount of electricity from the grid -- or they increasingly have their own power plants on site. And beyond that, they've become extremely controversial, with more and more communities pushing back on their development. So how do you get all your ducks in a row when a new project is proposed? Who provides the financing at which stage of the agreement? What are the legal complications that arise? On this episode, we speak with Travis Wofford, a partner at the law firm Baker Botts, who works in the firm's AI practice. We discuss all the intricacies of these projects, the challenges that arise, and how things have changed in this space just since the beginning of the year.

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Dan Ivascyn Is Excited About a New Era in Fixed Income Dec 08, 2025

Show notes

In the years since the financial crisis, bond investors didn't get much return for taking on risk. With low interest rates and little sign of inflation, investors had to accept lower-quality assets to get any semblance of yield. Now that's changing according to Dan Ivascyn, the chief investment officer of Pimco, one of the biggest bond fund managers around. In this special 10-year anniversary episode, Dan reflects on longer-term trends in the bond market, as well as more immediate issues like independence at the Federal Reserve, concerns around data center financing, and worries of "dangerous" and inflated credit ratings.

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How Microsoft Excel Conquered Corporate America Dec 07, 2025

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Excel. Ifyou work in corporate America, that word either inspires laser-focused productivity or pure dread. Over the last 40 years, the spreadsheet software has become synonymous with the best — and worst — of late-stage capitalism. It’s seeped into popular culture and, along the way, made Microsoft one of the world’s most valuable companies.But in a world of AI and new competition where Excel=Sum(39+1), can it stay on top? From the Big Take podcast, Bloomberg’s Dina Bass and Businessweek’s Max Chafkin join host Sarah Holder to track the rise and challenges ahead for one of the most ubiquitous programs around.
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Affirm's Max Levchin Breaks Down How Buy Now, Pay Later Really Works Dec 05, 2025

Show notes

Max Levchin probably knows as much about online payments as anyone. He was part of the original "PayPal mafia" before going on to become co-founder and CEO of Affirm, the $22 billion player in the Buy Now, Pay Later industry that's hoping to disrupt the incumbent credit card companies. While BNPL is booming, there is still a lot of confusion about how it works, how it makes money, and how transparent its activities are. On this episode, we speak with Max about why he started his company, and why he believes that BNPL offers a superior product to traditional forms of payment and credit. We also discuss the current state of the economy, AI, and what he sees as the role of crypto in payments.
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