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    Life Sciences

    NYU Langone Insights on Psychiatry

    Conversations about complex psychiatric cases and evolving treatments. Host Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, speaks with NYU Langone faculty about diagnostic reasoning, treatment decisions, and the ethical questions that arise in clinical practice.

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    Copyright: © 2023 NYU Langone Health

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    Latest Episodes:
    The Schizophrenia Puzzle is Solvable May 14, 2025
    Show notes

    There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation explores what happens when you bring humanity, structure, and innovation to a population too often left behind.

    Also discussed:

    • The first novel schizophrenia drug in over 50 years (Cobenfy)
    • Why clozapine is underused—and how that may finally change
    • The potential of brain imaging and biomarkers in psychiatric treatment
    • What a real community mental health system looks like
    • Why trust, not just treatment, is essential for recovery

    🔍 Topics Covered

    00:00 Introduction
    00:30 Dr. Frankle's Current Work
    01:08 Advancements in Schizophrenia Research
    02:29 Challenges and New Treatments in Schizophrenia
    05:02 Precision Medicine in Psychiatry
    05:59 PET Scans and Brain Energetics
    09:46 Barriers to Effective Treatment
    11:51 Clozapine and Treatment Access
    13:38 Wraparound Services and Community Care
    14:46 Early Screening and Public Health Interventions
    18:32 Mandated Treatment and Patient Engagement
    30:08 Homelessness and Mental Health
    34:54 Future Directions in Schizophrenia Treatment
    38:09 Conclusion

    📚 Related Resources

    W. Gordon Frankle, MD, MBA
    Schizophrenia care at NYU Langone
    NYU Langone Hospital—Brooklyn
    3 Things to Know About Cobenfy (Yale Medicine)
    🙌 Support & Engage

    If you enjoyed this episode, please like, share, and subscribe to support real conversations about transforming mental health care.

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    How Psychedelics Rewire the Brain May 07, 2025
    Show notes

    How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs.

    Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.

    🔍 Topics Covered:

    00:00 Introduction
    00:15 Dr. Siegel's Current Work
    01:01 Past Research and Human Psilocybin Imaging Study
    02:39 Understanding Brain Changes and Biomarkers
    06:13 Mechanisms of Action and Plasticity
    12:51 Surprising Findings and Context Dependence
    16:34 Challenges and Future Directions in Psychedelic Research
    20:46 Advanced Imaging and Personalized Treatment Plans
    24:15 Setbacks and Lessons in Psychedelic Medicine
    28:40 Emerging Areas in Neuropsychopharmacology
    31:46 Conclusion
    📚 Related Resources:

    Joshua Siegel, MD, PhD
    NYU Langone Health’s Center for Psychedelic Medicine
    The Multidisciplinary Association for Psychedelic Studies (MAPS)
    “Psychedelic and Dissociative Drugs as Medicines” (NIH)
    🙌 Support & Engage: Enjoyed this episode? Like, comment, and share to support science-based conversations about mental health.

    🔔 Don’t forget to subscribe for more interviews with top psychiatric researchers.

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    Can AI Help Prevent PTSD? Apr 30, 2025
    Show notes

    What if a simple conversation in the emergency room could reveal who’s most at risk for PTSD before symptoms even begin? Katharina Schultebraucks, PhD, shares her innovative work on using machine learning to forecast mental health outcomes and explains how AI could revolutionize how we detect, prevent, and treat psychiatric disorders. Dr. Schultebraucks is Co-Director of the Computational Psychiatry Program and Associate Professor in the Department of Psychiatry and Population Health at NYU Grossman School of Medicine.

    🔍 Topics Covered
    00:00 Introduction
    00:23 Current Work and Research Focus
    01:29 Objective Measures in Psychiatry
    02:50 Predicting PTSD Risk
    04:28 Early Preventive Interventions
    05:47 Machine Learning in Mental Health
    09:49 Challenges and Surprises in Research
    22:46 Burnout in Emergency Department Providers
    27:17 Precision Psychiatry and Future Directions
    29:35 Conclusion

    📚 Related Resources
    -Katharina Schultebraucks, PhD
    -Computational Psychiatry Program in NYU Langone’s Department of Psychiatry
    -“Dissecting racial bias in an algorithm used to manage the health of populations” by Ziad Obermeyer, et al
    -PTSD Treatment at NYU Langone Health

    🔔 Subscribe for more conversations at the intersection of mental health and innovation.
    📢 Like, comment, and share if this episode sparked your thinking.

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    ADHD at School: What Actually Helps Apr 23, 2025
    Show notes

    How do you help a child with ADHD stay organized, on task, and confident in school? Richard Gallagher, PhD, a child and adolescent psychologist at NYU Langone Health, shares groundbreaking research on organizational skills training for children with ADHD—a behavioral treatment that’s changing lives and improving classroom performance. This episode dives into how executive functioning challenges manifest in real life, the strengths (and limits) of technology, and the power of parent training and therapeutic coaching to help children thrive.

    Dr. Richard Gallagher is Associate Professor in the Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine, and Director of the Organization Skills Program.

    🔍 Topics Covered

    00:00 Introduction
    00:19 Current Research on Organizational Skills
    01:06 Executive Functioning and Practical Interventions
    02:37 Impact of Interventions on ADHD
    04:41 Expanding Research and Brain Connectivity
    05:08 Medication and Organizational Skills
    08:11 Technology in ADHD Assessment
    15:39 Effective Parenting Styles for ADHD
    23:10 Non-Pharmacological Treatments and Future Research
    25:58 Conclusion and Final Thoughts

    📚 Related Resources

    👨‍⚕️More about Dr. Richard Gallagher
    🔬 NYU Child Study Center
    📘 “Organizational Skills Training for Children with ADHD” by Richard Gallagher, Howard B. Abikoff, and Elana G. Spira
    📝 CHADD Parent Training Resources
    📈 CDC ADHD Parent Guide

    🙌 Support & Engage

    If this episode was helpful, please like, share, and subscribe to support the series and spread awareness about evidence-based ADHD care.

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    The Hidden Adult ADHD Crisis Apr 16, 2025
    Show notes

    ADHD isn’t just a childhood condition—many adults go undiagnosed for years. Lenard Adler, MD, Director of the Adult ADHD Program at NYU Langone Health, breaks down the nuances of ADHD in adults, the challenges of proper diagnosis, and the latest treatments available. Learn about his research, the screening tools his team has developed, and what’s on the horizon for adult ADHD care.

    🔍 Topics Covered:

    00:00 Introduction
    00:44 Dr. Adler’s Current Research Focus
    01:47 Importance of Proper Assessment
    03:44 Challenges in Diagnosing Adult ADHD
    06:15 Gender Differences in ADHD Diagnosis
    07:51 Impact of ADHD on Lifespan
    10:10 Comorbidities and Treatment Approaches
    14:54 Medication and Treatment Strategies
    21:15 Medication Shortages and Solutions
    28:42 Recent Developments in ADHD Research
    35:01 Screening and Diagnostic Tools
    37:33 Conclusion

    📚 Related Resources:

    • Lenard A. Adler, MD (official bio)
    • Adult ADHD Program at NYU Langone Health
    • Adult Self-Report Scale (ASRS) Screener
    • Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study | The British Journal of Psychiatry
    • American Professional Society of ADHD and Related Disorders (APSARD)
    • CHADD: ADHD Resources and Support

    🙌 Support & Engage: If you found this episode helpful, please like, comment, and share to spread awareness.

    🔔 Don’t forget to subscribe to stay updated on new episodes.

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    How to Make Addiction Care Routine Apr 09, 2025
    Show notes

    Despite affecting more Americans than diabetes, substance use is often left out of routine medical care. In this episode, NYU Langone Health’s Jennifer McNeely, MD—a clinician investigator, primary care and addiction medicine physician—explains why that must change. From the surprising history behind addiction’s exclusion from mainstream medicine to the innovative screening tools shaping the future of care, this conversation is a must-listen for anyone interested in addiction care and healthcare policy.

    Jennifer McNeely, MD, is an Associate Professor of Medicine and Population Health at NYU Grossman School of Medicine and co-director of the Section on Tobacco, Alcohol, and Drug Use.

    🔍 Topics Covered:

    00:00 – Introduction
    01:15 – Why addiction hasn’t been part of traditional medical care
    05:00 – What medications can primary care providers actually prescribe?
    07:00 – Why lifting legal barriers isn’t enough
    08:00 – Making substance use screening part of routine care
    11:50 – The power of self-report screening tools
    13:30 – What primary care physicians can actually do after screening
    16:10 – Real-world clinical impact of identifying substance use
    18:00 – Overcoming stigma and “we don’t do that here” culture
    22:17 – Can AI help with screening and care prioritization?

    📚 Related Resources:

    Jennifer McNeely, MD
    Addiction Treatment at NYU Langone
    NIDA’s Resources for Clinicians
    Substance Use Screening Tools (NIDA)

    🙌 Support & Engage: If you found this episode helpful, please like, comment, and share to spread awareness.

    🔔 Don’t forget to subscribe to stay updated on new episodes.

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    The Key to Effective Addiction Care Apr 02, 2025
    Show notes

    What makes addiction treatment truly effective? Behavioral scientist Charles Neighbors, MBA, PhD, shares groundbreaking research on the importance of therapeutic relationships, harm reduction, and human connection—love!—in treating substance use disorders. Dr. Neighbors is an Associate Professor in the Departments of Population Health, and Psychiatry at NYU Grossman School of Medicine.

    💡 Topics Covered

    00:00 Introduction to Dr. Charles Neighbors
    01:37 The biggest challenges in addiction treatment
    02:24 The Importance of Therapeutic Relationships
    05:59 Defining “good treatment” and why love matters
    08:05 The role of therapeutic alliance in patient outcomes
    14:06 Barriers to change in addiction treatment systems (incl. stigma)
    22:04 Harm reduction and safe injection sites: What does the science say?
    30:36 Future directions in addiction policy and treatment

    📚 Related Resources

    • Charles J. Neighbors, MBA, PhD (official bio)
    • Dr. Neighbors’ Lab - Health Evaluation & Analytics Lab (HEAL)
    • Addiction Treatment at NYU Langone
    • Understanding Harm Reduction: National Institute on Drug Abuse (NIDA)
    • "Motivational Interviewing" by William R. Miller and Stephen Rollnick
    • Community Reinforcement and Family Training (CRAFT)
    • SAMHSA’s National Helpline for Mental Health, Drug, Alcohol Issues
    • New York State Office of Addiction Services and Supports (OASAS)

    🔔 Subscribe for more insights on mental health & addiction treatment!

    👍 If you found this video helpful, please like, comment, and share to spread awareness!

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    Pediatric ADHD: Precision Strategies (with Samuele Cortese, MD, PhD) Apr 16, 2024
    Show notes

    For the final episode of Season 2, we're joined by Dr. Samuele Cortese, Professor of Child and Adolescent Psychiatry at the University of Southampton (UK) and Adjunct Full Professor at NYU Langone. Together we explore the intersection of pediatric ADHD and precision psychiatry, including the disorder’s genetic underpinnings and evolving treatment options.
    00:00 Introduction
    00:54 Dr. Cortese's Research Journey
    02:11 Global Perspectives and Challenges in ADHD Treatment
    03:51 Advances in ADHD Diagnosis and Treatment
    06:41 Role of Genetics in ADHD
    09:33 Precision Treatment and Stratification
    12:17 Treatment Adherence and Shared Decision-Making
    23:55 Connection Between ADHD and Obesity
    28:39 Non-Stimulant Alternatives and Future Directions in ADHD Treatment
    32:16 Non-Pharmacological Treatments
    37:28 Advice for Clinicians and Closing Thoughts

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    Pediatric ADHD: A Lifespan Approach (with Timothy Wilens, MD) Apr 09, 2024
    Show notes

    Dr. Timothy Wilens is a Professor of Psychiatry at Harvard Medical School and Chief of the Division of Child and Adolescent Psychiatry at Massachusetts General Hospital. His research interest include the relationship between ADHD, bipolar disorder, and substance use disorders; ADHD pharmacotherapy; and stimulant medication misuse.
    On this episode, Dr. Wilens discusses the importance of early diagnosis and intervention in ADHD, as well as its lifelong implications. He takes us through the evolution of ADHD treatment, from behavioral therapies to modern pharmacological interventions, including stimulant and non-stimulant medications, and the application of digital therapeutics. The conversation also touches on the stigma surrounding ADHD, the role of precision medicine, and the future of ADHD research.
    00:00 Introduction
    02:50 Evolution of ADHD Treatment
    04:43 Stigma and Misconceptions
    12:18 Importance of Early Intervention
    15:02 ADHD Symptoms and Treatment Approaches
    30:02 Addressing Concerns About Stimulant Medications
    35:50 Navigating the Complexities of ADHD Medication
    41:22 Future of ADHD Research and Treatment
    43:20 Conclusion

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


    Schizophrenia (with Ira Glick, MD) Apr 02, 2024
    Show notes

    Dr. Ira Glick is Professor Emeritus of Psychiatry and Behavioral Sciences at Stanford University Medical Center, where he has served as director of the Schizophrenia Research Clinic. On this episode, he discusses his research journey, which began in the 1960s and followed a shift from psychoanalysis to biological psychiatry. He addresses the broken social safety net for schizophrenia patients, including the controversial topic of treating some patients against their will, as well as the challenges of medication adherence, and the stigma surrounding severe mental illness.
    00:00 Introduction
    00:49 Evolution of Schizophrenia Treatment
    04:34 Science Behind Schizophrenia Medications
    07:39 Addressing the Public Health Challenges of Schizophrenia
    11:15 Stigma and Misunderstanding of Severe Mental Illness
    21:44 Innovative Treatment Approaches and the Future of Schizophrenia Care
    31:36 Importance of Public Health Interventions and Political Will
    35:45 Closing Remarks and Future Directions

    This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.

    Senior Producer: Jon Earle


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