New Books in Medicine

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Pharmacological Histories Ep. 2: Mikkael A. Sekeres on the Drugs Fighting Leukemia May 11, 2023

Show notes

This episode offers an insight into the work of leading cancer specialist and author of When Blood Breaks Down, Mikkael A. Sekeres. 1 in 2 people will develop cancer in their lifetime, but thankfully treatment for the disease is rapidly changing and improving. I ask Mikkael about the drugs that allow people to beat cancer and live better with it.

When you are told that you have leukemia, your world stops. Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.

Sekeres, who writes regularly for the "Well" section of The New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimate conversations between Sekeres and his patients, and we watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.

The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

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Britta K. Ager, "The Scent of Ancient Magic" (U Michigan Press, 2022) May 10, 2023

Show notes

Magic was a fundamental part of the Greco-Roman world. Curses, erotic spells, healing charms, divination, and other supernatural methods of trying to change the universe were everyday methods of coping with the difficulties of life in antiquity. While ancient magic is most often studied through texts like surviving Greco-Egyptian spellbooks and artifacts like lead curse tablets, for a Greek or Roman magician a ritual was a rich sensual experience full of unusual tastes, smells, textures, and sounds, bright colors, and sensations like fasting and sleeplessness. Greco-Roman magical rituals were particularly dominated by the sense of smell, both fragrant smells and foul odors. Ritual practitioners surrounded themselves with clouds of fragrant incense and perfume to create a sweet and inviting atmosphere for contact with the divine and to alter their own perceptions; they also used odors as an instrumental weapon to attack enemies and command the gods. Elsewhere, odiferous herbs were used equally as medical cures and magical ingredients. In literature, scent and magic became intertwined as metaphors, with fragrant spells representing the dangers of sensual perfumes and conversely, smells acting as a visceral way of envisioning the mysterious action of magic.

The Scent of Ancient Magic (University of Michigan Press, 2022) by Dr. Britta Ager explores the complex interconnection of scent and magic in the Greco-Roman world between 800 BCE and CE 600, drawing on ancient literature and the modern study of the senses to examine the sensory depth and richness of ancient magic. Dr. Ager looks at how ancient magicians used scents as part of their spells, to put themselves in the right mindset for an encounter with a god or to attack their enemies through scent. She also examines the magicians who appear in ancient fiction, like Medea and Circe, and the more metaphorical ways in which their spells are confused with perfumes and herbs. This book brings together recent scholarship on ancient magic from classical studies and on scent from the interdisciplinary field of sensory studies in order to examine how practicing ancient magicians used scents for ritual purposes, how scent and magic were conceptually related in ancient literature and culture, and how the assumption that strong scents convey powerful effects of various sorts was also found in related areas like ancient medical practices and normative religious ritual.

This interview was conducted by Dr. Miranda Melcher whose doctoral work focused on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars.

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Michael Brown, "Emotions and Surgery in Britain, 1793-1912" (Cambridge UP, 2022) May 10, 2023

Show notes

In this innovative analytical account of the place of emotion and embodiment in nineteenth-century British surgery, Michael Brown examines the changing emotional dynamics of surgical culture for both surgeons and patients from the pre-anaesthetic era through the introduction of anaesthesia and antisepsis techniques. Drawing on diverse archival and published sources, Brown explores how an emotional regime of Romantic sensibility, in which emotions played a central role in the practice and experience of surgery, was superseded by one of scientific modernity, in which the emotions of both patient and practitioner were increasingly marginalised. Demonstrating that the cultures of contemporary surgery and the emotional identities of its practitioners have their origins in the cultural and conceptual upheavals of the later nineteenth century, this book challenges us to question our perception of the pre-anaesthetic period as an era of bloody brutality and casual cruelty. Emotions and Surgery in Britain, 1793-1912 (Cambridge UP, 2022) is available as open access.

Dr Michael Brown is a lecturer in Modern British History at Lancaster University.

Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube channel.

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Pharmacological Histories Ep. 1: Nancy D. Campbell on Naloxone May 09, 2023

Show notes

Drawing on interviews with approximately sixty advocates, drug users, former users, friends, families, witnesses, clinicians, and scientists; Nancy D. Campbell has drawn together a history of a defining tragedy of contemporary life; the overdose. I ask her about the reality of drug overdoses and one of the tools being used by activists to prevent more deaths--Naloxone.

For years, drug overdose was unmentionable in polite society. OD was understood to be something that took place in dark alleys--an ugly death awaiting social deviants--neither scientifically nor clinically interesting. But over the last several years, overdose prevention has become the unlikely object of a social movement, powered by the miracle drug naloxone. In OD, Nancy Campbell charts the emergence of naloxone as a technological fix for overdose and describes the remaking of overdose into an experience recognized as common, predictable, patterned--and, above all, preventable. Naloxone, which made resuscitation, rescue, and "reversal" after an overdose possible, became a tool for shifting law, policy, clinical medicine, and science toward harm reduction. Liberated from emergency room protocols and distributed in take-home kits to non-medical professionals, it also became a tool of empowerment.

After recounting the prehistory of naloxone--the early treatment of OD as a problem of poisoning, the development of nalorphine (naloxone's predecessor), the idea of "reanimatology"--Campbell describes how naloxone emerged as a tool of harm reduction. She reports on naloxone use in far-flung locations that include post-Thatcherite Britain, rural New Mexico, and cities and towns in Massachusetts. Drawing on interviews with approximately sixty advocates, drug users, former users, friends, families, witnesses, clinicians, and scientists--whom she calls the "protagonists" of her story--Campbell tells a story of saving lives amid the complex, difficult conditions of an unfolding unnatural disaster.

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Rapid Reviews: COVID-19 May 08, 2023

Show notes

Rapid Reviews: COVID-19 brings together urgency and scientific rigor so the world’s researchers can quickly disseminate new discoveries that the public can trust. Amy Brand (Director, The MIT Press) and Vilas Dhar (Trustee, The Patrick J. McGovern Foundation) discuss this new overlay journal, its innovative goals, and its role as a proof-of-concept for new models of peer-review and rapid publishing.

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Stephen G. Post, "Dignity for Deeply Forgetful People: How Caregivers Can Meet the Challenges of Alzheimer's Disease" (Johns Hopkins UP, 2022) May 07, 2023

Show notes

How do we approach a "deeply forgetful" loved one so as to notice and affirm their continuing self-identity? For three decades, Stephen G. Post has worked around the world encouraging caregivers to become more aware of--and find renewed hope in--surprising expressions of selfhood despite the challenges of cognitive decline.

In Dignity for Deeply Forgetful People: How Caregivers Can Meet the Challenges of Alzheimer's Disease(Johns Hopkins University Press, 2022), Post offers new perspectives on the worth and dignity of people with Alzheimer's and related disorders despite the negative influence of "hypercognitive" values that place an ethically unacceptable emphasis on human dignity as based on linear rationality and strength of memory. This bias, Post argues, is responsible for the abusive exclusion of this population from our shared humanity. With vignettes and narratives, he argues for a deeper dignity grounded in consciousness, emotional presence, creativity, interdependence, music, and a self that is not "gone" but "differently abled." Post covers key practical topics such as:

- understanding the experience of dementia

- noticing subtle expressions of continuing selfhood, including "paradoxical lucidity"

- perspectives on ethical quandaries from diagnosis to terminal care and everything in between, as gleaned from the voices of caregivers

- how to communicate optimally and use language effectively

- the value of art, poetry, symbols, personalized music, and nature in revealing self-identity

- the value of trained "dementia companion" dogs

At a time when medical advances to cure these conditions are still out of reach and the most recent drugs have shown limited effectiveness, Post argues that focusing discussion and resources on the relational dignity of these individuals and the respite needs of their caregivers is vital. Grounding ethics on the equal worth of all conscious human beings, he provides a cautionary perspective on preemptive assisted suicide based on cases that he has witnessed. He affirms vulnerability and interdependence as the core of the human condition and celebrates caregivers as advocates seeking social and economic justice in an American system where they and their loved ones receive only leftover scraps. Racially inclusive and grounded in diversity, Dignity for Deeply Forgetful People also includes a workshop appendix focused on communication and connection, "A Caregiver Resilience Program," by Rev. Dr. Jade C. Angelica.

Stephen G. Post is the director of the Center for Medical Humanities, Compassionate Care, and Bioethics at the Renaissance School of Medicine at Stony Brook University.

Caleb Zakarin is the Assistant Editor of the New Books Network.

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Break on Through: Radical Psychiatry and the American Counterculture May 02, 2023

Show notes

In Break On Through, Lucas Richert explores Anti-psychiatry, psychedelics, and radical challenges to psychiatry and the conventional treatment of mental health in the 1970s. In this interview Lucas discusses the issues that run through the sixties and seventies and how they're forming debates about mental health today.

"Antipsychiatry," Esalen, psychedelics, and DSM III: Radical challenges to psychiatry and the conventional treatment of mental health in the 1970s.

The upheavals of the 1960s gave way to a decade of disruptions in the 1970s, and among the rattled fixtures of American society was mainstream psychiatry. A "Radical Caucus" formed within the psychiatric profession and the "antipsychiatry" movement arose. Critics charged that the mental health establishment was complicit with the military-industrial complex, patients were released from mental institutions, and powerful antipsychotic drugs became available. Meanwhile, practitioners and patients experimented with new approaches to mental health, from primal screaming and the therapeutic use of psychedelics to a new reliance on quantification. In Break on Through, Lucas Richert investigates the radical challenges to psychiatry and to the conventional treatment of mental health that emerged in the 1970s and the lessons they offer for current debates.

Drawing on archives and government documents, medical journals, and interviews, and interweaving references to pop (counter)culture into his account, Richert offers fascinating stories of the decade's radical mental health practices. He discusses anti-Vietnam War activism and the new diagnosis of post-traumatic stress disorder given to some veterans; the radical psychiatrists who fought the system (and each other); the entry of New Age-style therapies, including Esalen's Human Potential Movement, into the laissez-faire therapeutic marketplace of the 1970s; the development of DSM III; and the use of LSD, cannabis, and MDMA.

Many of these issues have resonance today. Debates over medical marijuana and microdoses of psychedelics echo debates of the 1970s. With rising rates of such disorders as anxiety and depression, practitioners and patients continue to search for therapeutic breakthroughs.

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Ian Hembrow, "Ralph Edwards: Rare Events--The Inside Story of a Worldwide Quest for Safer Medicines" (Springer, 2023) Apr 30, 2023

Show notes

Medical treatments designed to help people can also be harmful or fatal. Around 2.5 million people die this way each year. So if any kind of medicine makes someone unwell, they or their doctor should report it. Those reports, from nearly every country in the world, go to the Uppsala Monitoring Centre (UMC) in Sweden. As the Centre’s first director, Professor Ivor Ralph Edwards transformed it from a tiny operation with limited horizons into an internationally acclaimed scientific organization at the heart of the World Health Organization’s Programme for International Drug Monitoring. He was then succeeded by his wife, Dr Marie Lindquist.

Ian Hembrow's Ralph Edwards: Rare Events--The Inside Story of a Worldwide Quest for Safer Medicines (Springer, 2023) is the story of how a new science developed and a passionate and dedicated pursuit of worldwide medicines safety, with an unerring focus on the welfare of patients. The pioneering work of Ralph, Marie and their collaborators on every continent protected the lives of millions of people. It may yet improve the lives of billions more.

Victoria Phillips is a Visiting Fellow at the London School of Economics in the Department of International History.

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Maurits Bastiaan Meerwijk, "A History of Plague in Java, 1911-1942" (SEA Program Publications, 2022) Apr 30, 2023

Show notes

I was very excited to chat with Maurits Bastiaan Meerwijk as we share some obsessions, namely rats and plague in colonial Southeast Asia. His A History of Plague in Java, 1911-1942 (Southeast Asia Program Publications, 2022) is an engaging study of a massive public health campaign in the Dutch East Indies. As he records the most invasive colonial policy in Indonesian history, his work ties together the histories of disease, imperialism, and modernity. A History of Plague in Java, 1911-1942 will be of interest to Southeast Asianists, scholars of disease, and anyone interested the origins of modern state systems.

Dr. Meerwijk earned his Ph.D in History at the University of Hong Kong with a dissertation entitled Dengue Fever in Modern Asia. He has been a Research Associate at the University of St. Andrews and a Lecturer at the University of Hong Kong. He is currently a postdoc researcher at the University of Leiden and the scientific secretary at the Health Council of the Netherlands. A History of Plague in Java, 1911-1942 is his first book.

Michael G. Vann is a professor of world history at California State University, Sacramento. A specialist in imperialism and the Cold War in Southeast Asia, he is the author of The Great Hanoi Rat Hunt: Empires, Disease, and Modernity in French Colonial Vietnam (Oxford University Press, 2018). When he’s not reading or talking about new books with smart people, Mike can be found surfing in Santa Cruz, California.

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The Future of Germs: A Discussion with Jonathan Kennedy Apr 28, 2023

Show notes

Have germs or humans done the most to shape the world’s history? Did Homo Sapiens get the better of the Neanderthals because of superior brainpower or because of better resistance to some infectious disease? And are germs part of the story behind the fall of Rome and rise of Islam? Owen Bennett Jones talks germs with Jonathan Kennedy of London University. Kennedy is the author of Pathogenesis: A History of the World in Eight Plagues (Crown Publishing, 2023).

Owen Bennett-Jones is a freelance journalist and writer. A former BBC correspondent and presenter he has been a resident foreign correspondent in Bucharest, Geneva, Islamabad, Hanoi and Beirut. He is recently wrote a history of the Bhutto dynasty which was published by Yale University Press.

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