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ModPath Chat — Health & Fitness
ModPath Chat

ModPath Chat is the official podcast of Modern Pathology, the journal of the US and Canadian Academy of Pathology (USCAP). ModPath Chat features interviews with authors, opinion leaders and experts on the latest science, technology, and developments in the field of pathology. The monthly podcast series is hosted by Dr. George J. Netto, the Editor-in-Chief of Modern Pathology and the Chair of Pathology at the University of Alabama in Birmingham

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Latest Episodes:

USCAP 2021 Long Course: Neuroendocrine Tumors of Lung, a Decade of Change! Apr 13, 2021

Show notes

In this third of four special episodes highlighting the USCAP 2021 Long Course on Pulmonary Pathology, our host discusses with Dr. Natasha Rekhtman of Memorial Sloan Kettering Cancer Center (MSKCC) her presentation on Neuroendocrine tumors. Dr. Rekhtman offers her perspective on the current status of the classification of pulmonary NE tumors and the “grey zones” that remain to be tackled.

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USCAP 2021 Long Course: “Pulmonary Pathology: Practical Problems and Solutions”. HP, FHP, CTILD, UIP/IFP and more! Mar 30, 2021

Show notes

In this second of four special episodes highlighting the USCAP 2021 Long Course on Pulmonary Pathology, our host is joined by two distinguished faculty: Dr. Andrew Churg of the University of British Colombia and Dr. Maxwell Smith from the Mayo Clinic Arizona. The two international experts on interstitial lung disease (ILD) share their valuable perspective on “where we are and where we need to go” in our approach to the diagnosis and classification of hypersensitivity pneumonitis (HP) and usual interstitial pneumonitis (UIP).

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USCAP 2021 Long Course: "Pulmonary Pathology: Practical Problems and Solutions”. Meet the Directors! Mar 09, 2021

Show notes

In this special episode, Dr. Sanja Dacic and Dr. Mary Beth Beasley highlight the topics of the upcoming Long Course on Pulmonary Pathology, that will air on March 13th during the USCAP 2021 annual meeting. As international experts and thought leaders on thoracic tumors, they have been heavily involved with developing guidelines for molecular biomarkers of mesotheliomas and Lung cancers. Tremendous advances have taken place in pulmonary pathology. The guests discuss their take on these exciting advancements and share their future vision.

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MHC class I loss in endometrial carcinoma Mar 02, 2021

Show notes

MHC class I loss by tumor cells decreases tumor neoantigen presentation to the immune system and therefore represents a possible mechanism of immunotherapeutic resistance in cancers that otherwise could be good candidates for checkpoint inhibition (e.g. mismatch repair (MMR)-deficient and PD-L1-positive tumors). In this episode our guest, Dr. Anne Mills discusses her recent Modern Pathology publication on loss of MHC class 1 expression in some endometrial cancers. Study by Friedman et al, MHC class I loss in endometrial carcinoma: a potential resistance mechanism to immune checkpoint inhibition. Modern Pathology, 34, 627-636, 2021. https://www.nature.com/articles/s41379-020-00682-w

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Predictors of metastases in non-seminomatous TGCT: The rationale for evolution of the pathologic staging system? Feb 16, 2021

Show notes

Pathological risk factors for metastatic disease in patients with testicular non-seminomatous germ cell tumors are debated. The tumor-node-metastasis (TNM) classification eighth edition for testicular cancers includes divergent versions, by the International Union Against Cancer (UICC) and by the American Joint Committee for Cancer (AJCC). In this episode we discuss with Dr. Daniel Berney his recent study on the topic. Study by Scandura et al, Pathological predictors of metastatic disease in testicular non-seminomatous germ cell tumors: which tumor-node-metastasis staging system? Modern Pathology, 2020. https://www.nature.com/articles/s41379-020-00717-2

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Composite Nuclear Grading System to Predict Survival in Epithelioid Peritoneal Mesothelioma Feb 02, 2021

Show notes

This episode’s guest, Dr. David Chapel, was the recipient of the 2020 USCAP Stephen Vogel Award for his research as a trainee in the University of Chicago! Here, he discusses his recent report on a multi-institutional cohort of 225 malignant peritoneal mesotheliomas, assessed for 21 clinical, morphologic, and immunohistochemical potential prognostic parameters. The exemplary study, published in Modern Pathology, clarifies the complex interaction of clinical and pathologic features in peritoneal mesothelioma and validates the prognostic significance of a standardized nuclear grading system.

Study by Chapel et al, Malignant peritoneal mesothelioma: prognostic significance of clinical and pathologic parameters and validation of a nuclear-grading system in a multi-institutional series of 225 cases. Modern Pathology, 34, 380-395, 2021. https://www.nature.com/articles/s41379-020-00688-4

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APOBEC, the enemy within us! Jan 19, 2021

Show notes

APOBEC3B (A3B) is a newly recognized endogenous source of mutations in a range of human cancers by inflicting C-to-T or C-to-G base substitutions in 5′-TCA/T trinucleotide

motifs. In this episode, Drs. Harris and Argyris discuss the impact of their recent findings on the role of APOBEC3A in Head and Neck Squamous Cancer. Study by Argyris et al, Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers. Modern Pathology, 34, 280-290, 2020.

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Serous Carcinoma of The Uterine Cervix: A Vanishing Entity Jan 05, 2021

Show notes

The Host discusses with Dr. Philip IP (Li Ka Shing Faculty of Medicine, University of Hong Kong) his recent study re-assessing Cervical adenocarcinoma with Serous-Like morphology in light of the recent changes in the Classification of cervical adenocarcinomas. Study by Wong et al, Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas. Modern Pathology, 2020. https://www.nature.com/articles/s41379-020-0627-8

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Top 20 of 2020, The Year in Review Dec 29, 2020

Show notes

Dr. Netto reflects on the topics of the most cited manuscripts published in Modern Pathology in 2020. A brief discussion of five selected studies involving COVID-19, DICER1, NTRK, Precursor lesions of HPV-Independent Vulvar Squamous Cell Carcinoma and Applications of Computational Pathology and Artificial Intelligence in Pathology.

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Machine Learning-Based Algorithm to Predict Death from COVID-19 Dec 22, 2020

Show notes

Dr. Netto discusses with his two guests, Dr. Peter MCaffrey from the UTMB in Galveston and Dr. Adam Booth, their publication on developing a machine learning model using 5 serum

chemistry laboratory parameters for the prediction of death from COVID-19. The discussion is followed by a conversation on the exciting role of AI and social media in Pathology given the unique expertise of the guests. Study by Booth et al, Development of a prognostic model for mortality in COVID-19 infection using machine learning. Modern Pathology, 2020. https://www.nature.com/articles/s41379-020-00700-x

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