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    Science

    Mind & Matter

    Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

    The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

    Not medical advice.

    At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.

    As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.

    I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.

    My beliefs:

    • Taking ownership of your health starts with taking ownership of your information diet.
    • All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
    • Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.

    Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

    • “Γνῶθι σεαυτόν” (Know thyself)
    • “Μηδὲν ἄγαν” (Nothing in excess)
    • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
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    Copyright: © 2025 Nick Jikomes

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    Latest Episodes:
    Consciousness, Anesthesia, Coma, Vegetative States, Sleep Pills (Ambien), Ketamine, AI & ChatGPT | Alex Proekt | 101 Dec 25, 2022
    Show notes

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    Nick talks to anesthesiologist & neuroscientist Dr. Alex Proekt, who runs a lab at the University of Pennsylvania, about altered states of consciousness. They discuss: NREM & REM sleep, anesthesia & anesthetic drugs like propofol; coma & vegetative states; sleeping pills like Ambien; the relationship between consciousness & the underlying brain dynamics; how ketamine differs from other anesthetics & what it does to brain activity; AI & ChatGPT.
    *Not medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Infectious Disease, Epidemiology, Pandemics, Health Policy, Big Science, Politicization of Science | Jay Bhattacharya | Episode 100 Dec 19, 2022
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    Nick talks to Jay Bhattacharya, MD, PhD, who is a professor of medicine & economics at Stanford University. They discuss various aspects of the COVID pandemic, such as: how infectious, transmissible, and deadly SARS-CoV-2 is; mRNA vaccines, how well they stop transmission vs. severe COVID, and whether they can induce negative side effects such as myocarditis; how well masks really work; Jay's inclusion in the "TwitterFiles" and the suppression of speech on social media; what he thinks of Elon Musk after meeting him; his thoughts on the future of public health governance in the US.
    Related episodes:

    • M&M #61: Public Health, Pandemics, Epidemiology, SARS-CoV-2 & COVID Public Policy | Martin Kulldorff

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Developmental Neurobiology, Brain Organoids, Human-Animal Transplantation, Reverse Engineering the Human Brain | Sergiu Pasca | Episode 99 Dec 15, 2022
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    Nick talks to Dr. Sergiu Pasca, a developmental neuroscientist and professor at Stanford University. They discuss topics related to human brain development, the origins of neuropsychiatric disease like autism & schizophrenia, new technologies for studying brain development, stem cells, and recent experiments from Dr. Pasca'a lab utilizing brain "organoids," "assembloids," and human-animal transplantations.
    *Not medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Neural Computation, AI, Serotonin, Psychedelics, Subjective Experience | Zach Mainen | Episode 98 Nov 28, 2022
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    Nick talks to computational neuroscientist Dr. Zach Mainen, a neuroscientist and director of the Champalimaud Neuroscience Programme at the Centre of the Unknown in Lisbon, Portugal. His lab studies the neuroscience of decision making, neuromodulation & behavior using both experimental and computational approaches.
    They discuss: what kinds of things animal brains are actually computing, and to what extent we can think about brains like computers; the difference between neurotransmitters and neuromodulators in the brain, including some discussion of what specific neuromodulators like dopamine and serotonin do in the brain; and we also discussed some of the research his lab is starting to do on serotonergic psychedelics, including how he thinks about whether the subjective effects of psychedelics are likely to be important for the therapeutic and neuroplastic effects.

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    How Did the SARS-CoV-2 Virus Originate? | Alex Washburne | Episode 97 Nov 21, 2022
    Show notes

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    Nick talks to mathematical biologist Dr. Alex Washburne about the origins of the SARS-CoV-2 virus.

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    MDMA, Microdosing LSD, THC & Memory, Human Psychopharmacology | Harriet de Wit | Episode 96 Nov 14, 2022
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    Nick talks to experimental psychologist Dr. Harriet de Wit, a professor at the University of Chicago whose lab studies the behavioral effects of psychoactive drugs on humans. They discuss: the effects of MDMA on emotional perception and touch sensation; the effects of microdosing LSD; THC's impact on memory.
    *Not medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Purpose, Value, Evolution, Consciousness, Sentience, Life & Emergence of Mind From Matter | Terrence Deacon | Episode 95 Nov 07, 2022
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    Nick talks to biological anthropologist & neuroscientist Dr. Terrence Deacon, who is a professor of biological anthropologist at UC-Berkeley and a leading thinker on the evolution of language, consciousness and human cognition. They discuss: how end-directed systems, such as life, can emerge from non-life; how complexity evolves once life originates; the origins of sentience and a sense of self; the evolution of the nervous system and consciousness; information, value, and "aboutness" in the universe; and more.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Neuroscience of Pleasure, Reward, Liking vs. Wanting, Motivation, Food vs. Drug Addiction & Emotion | Kent Berridge | Episode 94 Oct 30, 2022
    Show notes

    Send us Fan Mail

    Nick talks to neuroscientist Dr. Kent Berridge, a professor of psychology & neuroscience at the University of Michigan. They discuss: the neurobiology of the brain processes rewards and generates pleasure & motivation; the difference between "liking" and "wanting"; hunger and whether food addiction is similar to drug addiction; emotion and consciousness; and more.
    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Marijuana, Cognition, Psychosis, Addiction, Cannabinoids, THC, CBD, THCV | Amir Englund | Episode 93 Oct 24, 2022
    Show notes

    Send us Fan Mail

    Nick talks to Dr. Amir Englund, a psychopharmacologist at the Institute of Psychiatry, Psychology & Neuroscience at King's College, London. Dr. Englund's research focuses on the effects of cannabis, medical marijuana and specific cannabinoids (e.g. THC, CBD, THCV) on human cognitive function. They discuss topics including: what is the addiction liability of marijuana? What are the acute & chronic cognitive effects of THC, including how it impacts memory & executive function; how the effects of THC can be modulated by cannabinoids like CBD & THCV; the relationship between marijuana & THC and psychosis (e.g. schizophrenia); and more.
    *Not medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Diet, Protein, Amino Acids, Fasting, Metabolic Health & Aging | Dudley Lamming | Episode 92 Oct 17, 2022
    Show notes

    Send us Fan Mail

    Nick talks to molecular physiologist Dr. Dudley Lamming, a professor of medicine at the University of Wisconsin-Madison whose lab studies how the body responds to the nutrient and calorie content of food. We discuss: how the protein and amino acid composition of food impacts metabolic health & aging; branched chain amino acids & disease; sex differences between males & females in how diet affects health; fasting, calorie restriction & fasting; and more.
    *Not medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


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