MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes:

I'm Exhausted by Hope Nov 10, 2026

Show notes

This week, Jamie and Christina read listener emails from people navigating misdiagnoses, chronic illness, and the long road to finding answers. They discuss the pressure to stay hopeful, the frustration of feeling dismissed by professionals, and they catch up on all things Real Housewives.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

Ridge - Ridge’s biggest sale of the year is here! Head to https://Ridge.com/MESSY to get up to 49% off, plus holiday extras like gift bags and classic cuff beanies on qualifying orders while supplies last! #Ridgepod

Lola Blankets - Get 35% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

Caraway - The holidays are closer than ever, so get their gift (or yours) in time! Visit Carawayhome.com/messy to take advantage of this limited-time offer for up to 25% off.

Tin Can - Go to https://tincan.com/MESSY to get $10 off your first order. Exclusive for our listeners.

K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY That’s code MESSY at kay-eighteen hair dot com

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Jack Osbourne Nov 03, 2026

Show notes

This week, Christina and Jamie are joined by Jack Osbourne for an honest conversation about growing up in the spotlight, getting sober at 17, and being diagnosed with MS at just 26. Jack opens up about how he's navigated life's challenges, the importance of perspective, and what he's learned about resilience, fatherhood, and living with a chronic illness.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Blissy - Wake up with clearer skin, smoother hair, and cooler sleep. Use code MESSY for an extra 30% off at https://blissy.com/MESSY.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We're All Just Living This MeSsy Life Oct 27, 2026

Show notes

This week, Christina and Jamie read listener emails and discuss navigating life without a diagnosis, the challenges of parenting teenagers, learning to accept help, and the realities of getting older.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

OneSkin 0 Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY#oneskinpod

MyAlloy - With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Christina Is Back (Part 2) with Dr. Marwa Kaisey Oct 20, 2026

Show notes

In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles.

Send us an email: https://www.messythepodcast.com/contact

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Ridge - One thing to pack, five ways to power! Get 10% Off @Ridge with code MESSY at https://www.Ridge.com/messy

NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Christina Is Back (Part 1) Oct 20, 2026

Show notes

Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months.

Send us an email: https://www.messythepodcast.com/contact

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

ZocDoc - Head to https://Zocdoc.com/messy to get started and check that appointment off your to-do list!

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Learning to Love Every Version of Yourself with Tiffani Thiessen Oct 13, 2026

Show notes

This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code [MESSY]

Blissy - Wake up with clearer skin, smoother hair, and cooler sleep. Use code MESSY for an extra 30% off at blissy.com/MESSY.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui Oct 06, 2026

Show notes

This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

I Don’t Have a Lot of Fight in Me Right Now Sep 29, 2026

Show notes

This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/MESSY! #mudwtrpod

Alloy -With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How to Live With What You Can’t Control with Ana Rodriguez Sep 24, 2026

Show notes

In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to plan. They explore grief, resilience, uncertainty, and the ways we avoid our feelings by trying to fix them or find meaning too quickly.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Hardest Fight Is Learning to Rest with Alberto Crane Sep 22, 2026

Show notes

This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be strong. Alberto opens up about learning to slow down, embrace rest, and why sometimes being a fighter means knowing when not to push through.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

OneSkin - Get 15% off OneSkin with the code MESSYat https://www.oneskin.co/MESSY#oneskinpod

Zoc Doc - Ready to be seen? Check that appointment off your to-do list with Zocdoc https://zocdoc.com/ messy #sponsored

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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