MDS Podcast

Latest Episodes:

Distinguishing functional from idiopathic dystonia: A novel approach Feb 23, 2026

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Functional dystonia can closely mimic idiopathic dystonia, and objective physiological markers to support the diagnosis are still limited. In this episode, Dr. Michele Matarazzo speaks with Prof. Roberto Eleopra about a pilot study using poly-EMG during a controlled propofol sedation protocol to help differentiate functional from idiopathic dystonia. They discuss the study’s rationale and design, the key findings, and what this approach could (and could not) add to real-world diagnostic workflows in selected complex cases. Journal CME is available until February 19, 2027
Read the article.

Disease modification and Parkinson’s disease: Clinical trial design and population selection • 2025 MDS Congress Oct 20, 2025

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There have been nearly 30 years of disease modifying trials for PD, but little success. Prof. Tanya Simuni breaks down clinical trial design for a heterogenous disease like PD and discusses the future goals and importance of a biological definition.

Do social workers play a role in preoperative evaluation for DBS? Jul 21, 2025

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Ms. Nicole Duff and Dr. Amanda Currie discuss the potential role of the social worker in deep brain stimulation (DBS) and the work of Dr. Currie’s team in creating a simple pneumonic that could be used to determine whether a social worker's involvement would be beneficial to DBS patients. They also discuss the clinical implications of this study as well as possible future directions to further outline the role of the social worker in DBS. Read the article.

Differential diagnosis of myoclonus May 19, 2025

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Prof. Marina de Koning-Tijssen interviews Dr. Christos Ganos on the differential diagnosis of myoclonus. Dr. Ganos explains how he distinguishes between jerky movements based on clinical history and examination, and discusses the differential diagnosis across various parts of the body.

Disentangling the Cognitive Effects of Acute Levodopa in Parkinson's Disease Aug 05, 2024

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In this episode, Dr. Joseph Seemiller and Dr. Kelly Mills discuss the changes in cognitive performance in the OFF and ON states during an acute levodopa challenge in a large cohort of patients with Parkinson's disease. Their study's findings suggest divergent complex changes in processing speed and executive function. Read the article »

Do subjective cognitive complaints predict future incident cognitive impairment in people with Parkinson's disease? Jul 08, 2024

Show notes

Dr. Eduardo Fernández and Dr. Daniel Weintraub discuss whether subjective cognitive complaints can predict future incident cognitive impairment and other questions related to early cognitive impairment in people with Parkinson's disease, referencing Dr. Weintraub’s recent article, "Association between subjective cognitive complaints and incident functional impairment in Parkinson's disease" published in Movement Disorders. Read article »

Diagnosis of Late-Onset Wilson's Disease May 15, 2023

Show notes

Dr. Christelle Nilles talks with Dr. Hugo Morales Briceno about the clinical presentations of Wilson’s disease patients with onset after 40 years and the challenges of diagnosing patients with atypical neurological manifestations. Read the article.

Dystonia Series: Beyond “torsion": non-motor features of dystonia Feb 06, 2023

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In part 2 of the Dystonia Special Series, Dr. Francesca Morgante interviews Dr. Davide Martino on the non-motor features of dystonia.

Does glucocerebrosidase activity correlate with disease risk or phenotype severity in Parkinson's disease? Apr 11, 2022

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A discussion with Dr. Avner Thaler on the findings and implications of a study on the background of importance of GBA mutations and GCase activity in Parkinson's disease. Read the Article.

Dystonia | Congress 2019 Oct 24, 2019

Show notes

As part of the MDS Congress 2019 Special Issue, Dr. Sara Schaefer interviews Dr. Hyder Jinnah about notable research in dystonia and activities of the MDS Dystonia Study Group.

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