MDS Podcast

Latest Episodes:

Blocking alpha-synuclein propagation with perampanel Jun 22, 2026

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Dr. Norihito Uemura joins Prof. Tiago Outeiro to discuss perampanel, an AMPA receptor antagonist, and how it has been shown to block alpha-synuclein propagation and neurodegeneration in a mouse model of Lewy body disease. Dr. Uemura explains the mechanistic findings of transsynaptic propagation and the study limitations pertaining to mouse behavior. They also discuss perampanel’s established therapeutic ranges in epilepsy, review limited prior Parkinson’s data, and outline next steps including a potential clinical trial in Parkinson’s disease patients. Read article. Journal CME is available until June 5, 2027.

Breaking down functional movement disorders • 2025 MDS Congress Oct 27, 2025

Show notes

Functional movement disorders (FMDs) are the most common subgroup of functional neurological disorders. Prof. Selma Aybek breaks down current trends for FMDs, controversies, and treatment preferences, including implementing an interdisciplinary team.

Celebrating the Parkinson's community Apr 11, 2025

Show notes

On this special World Parkinson’s Day episode, Dr. Michele Matarazzo is joined by John Dean—speech-language pathologist and Chair of the MDS Allied Health Professionals Group—to explore the essential roles of care partners, allied health professionals, and the broader Parkinson’s community. From physiotherapists to family members, we shine a light on the many people who support those living with Parkinson’s disease every day. World Parkinson's Day

Chorea Series: Exploring medical and surgical management for chorea Jun 03, 2024

Show notes

Profs. Elena Moro and Ruth Walker discuss the management of chorea, including when this is appropriate. They focus on Huntington’s disease and the role of deep brain stimulation and other surgical interventions, in addition to medical management.

Chorea Series: Approach to patients with acquired choreas May 20, 2024

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Dr. Ruth Walker and Dr. Molly Cincotta discuss causes of acquired chorea and approach to the work-up of a patient with an acquired chorea.

Chorea Series: Update on therapies for Huntington's disease May 06, 2024

Show notes

In the latest installment of the Chorea Special Series, Dr. Ruth Walker interviews Prof. Sarah Tabrizi about the current state of therapies for Huntington’s disease, and what is coming down the pipeline.

Chorea Series: Approach to patients with genetic choreas Apr 22, 2024

Show notes

Dr. Ruth Walker invites Prof. Emilia Gatto and Dr. Kevin Peikert onto the MDS Podcast for the second episode of the Chorea Special series. Together they discuss the general approach to patients with chorea of genetic etiology, with specific clues to diagnosis in terms of neurological and other features. They also discuss the nomenclature of neuroacanthocytosis syndromes, specific clues to the diagnosis in the clinical presentation and laboratory findings.

Chorea Series: Phenomenology of Chorea Apr 08, 2024

Show notes

Guest editor Dr. Ruth Walker kicks off this special series on chorea by interviewing Prof. Joseph Jankovic on the phenomenology and his approach to the clinical examination of the patient with chorea.

Can dogs diagnose Parkinson's disease? Nov 14, 2022

Show notes

Dr. Sarah Lidstone interviews Dr. Chang-Qing Gao & Prof. Ji-fung Guo about their recent research on the sensitivity of sniffer dogs for diagnosing Parkinson's disease. Read the article.

Blinded RT-QuIC analysis of alpha-synuclein biomarker in skin tissue from Parkinson's disease patients Sep 01, 2021

Show notes

Dr. Sara Schaefer speaks with Dr. Anumantha Kanthasamy about RT-QuIC from skin tissues as a potential new biomarker for Parkinson's disease. Read the article

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