Masters of Scale

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The AI race to save American science and reshape medicine forever Oct 13, 2026

Show notes

Renee Wegrzyn spent her career building the future of American science — including ARPA-H, the White House agency created to accelerate health breakthroughs. Then the Trump administration showed her the door. Wegrzyn co-founded Transfyr to tackle what she calls one of the most overlooked issues in science: the magic hands problem. She joins Rapid Response to explain why fixing this unglamorous bottleneck is the prerequisite for everything AI promises to deliver in medicine, what the federal funding cuts are really costing science, and why she can feel the next Sputnik moment coming — even if she can’t quite name it yet.

Visit the Rapid Response website here: https://www.rapidresponseshow.com/

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Pioneers of AI: OpenAI’s Tibo Sottiaux doesn’t want humans to be an ‘afterthought’ Oct 10, 2026

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Thibault “Tibo” Sottiaux is OpenAI’s head of Product & Platform, making him responsible for the AI tools used by more than a billion users worldwide. Rana el Kaliouby spoke with Tibo on Pioneers of AI about why he’s “proud” OpenAI delayed its latest Astra model over safety concerns, the new suite of agentic products released at DevDay, and what it’s like to lead inside a frontier AI company in this extraordinary moment in history.

Learn more about Pioneers of AI: http://pioneersof.ai/

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Building a marketplace from scratch, with Hipcamp founder Alyssa Ravasio Oct 08, 2026

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Alyssa Ravasio loves using ‘coyote trickster energy’ to get more people to put down their technology. Her camping marketplace, Hipcamp, has grown into the largest source for booking campsites on public and private land. She talks with host Jeff Berman about scaling the company, learning to prioritize your health as a founder, and more.

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Kalshi vs. Everyone: Co-Founder Luana Lopes Lara on the lawsuits and the long game Oct 06, 2026

Show notes

Prediction markets incentivize truth. Everything else incentivizes clickbait. That's the core argument Luana Lopes Lara makes for Kalshi — the prediction market platform she co-founded that has gone from $5 billion to $22 billion in valuation in under a year, and is now being sued by New York's attorney general for $36 billion. Luana joins Rapid Response to make the case that Kalshi is fundamentally different from DraftKings — even though 75% of its volume is sports — explain why George Santos got banned for trying to trade on his own congressional attendance, and share what Kalshi's data actually says about the midterms. Plus the Timothée Chalamet dentist-chair ad, what ballet taught her about running a company, and what it's actually like to become the world's youngest self-made female billionaire.

Visit the Rapid Response website here: https://www.rapidresponseshow.com/

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Don't be boring: KCRW's Jennifer Ferro on building a brand people love Oct 01, 2026

Show notes

Jennifer Ferro is the former board chair of NPR and president of Southern California’s iconic public radio organization: KCRW. Ferro talks with host Jeff Berman about how nearly two decades as the founder’s deputy taught her to lead, why she thinks we deserve a better internet, and how the best defense of getting ignored is simple: Don’t be boring.

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Halloween meets GLP-1s: Hershey’s candy Super Bowl, with CEO Kirk Tanner Sep 29, 2026

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The second a brand like Hershey stops being culturally relevant, says its CEO Kirk Tanner, you should be worried. He joins Rapid Response to explain exactly what he's doing to make sure that never happens. Tanner also reveals why GLP-1 users are actually good for the candy business, how AI is now routing Hershey's sales force in real time through Target and Walmart, and why the Reese's Oreo collaboration (which generated $100 million in its first five months) is the model for how iconic brands find new energy. And with a major Hollywood film about Milton Hershey coming this fall, he talks about whether this is Hershey's Barbie moment.

Visit the Rapid Response website here: https://www.rapidresponseshow.com/

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Rapid Response: Stop creating businesses. Buy one instead, with Codie Sanchez Sep 26, 2026

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Own or be owned. That's Codie Sanchez's ultimatum for anyone serious about their financial future. The founder of Contrarian Thinking and author of the new book Own or Be Owned returns to Rapid Response to make her most impassioned case yet for why buying a small business is the most reliable path to wealth that most people are too scared to take. She breaks down what "cowboying" your business is costing you, and why AI isn’t a shortcut for everyone, but instead an accelerator for what's already inside you. Plus, the industries she'd invest in right now, and why most small business owners are solving the wrong problems.

Visit the Rapid Response website here: https://www.rapidresponseshow.com/

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How to build a billion-dollar sports team from scratch, with Golden State Valkyries’ Jess Smith Sep 24, 2026

Show notes

When Jess Smith became employee number one for the Bay Area’s WNBA expansion team, the future was a blank slate. Now, the Golden State Valkyries brand is boasting a unicorn valuation in just its second season. Smith talks with host Jeff Berman about building the brand from scratch, the rise of women’s professional sports, and why so many women in the C-Suite are former athletes.

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Rebranding in a war zone, with Prosper Global (formerly Mercy Corps) Sep 22, 2026

Show notes

The world has never faced so many humanitarian crises at once, and the systems built to respond to them are fraying. Tjada McKenna, CEO of Prosper Global — the organization long known as Mercy Corps — joins Rapid Response during UN General Assembly week to share what she's seeing firsthand from Syria to Sudan to Ukraine to Gaza, and why she rebranded a 40-year-old institution in the middle of a funding crisis rather than in spite of one. She explains how the Strait of Hormuz conflict is quietly writing next year's food shortages into fragile countries right now, why Russia's playbook of attacking civilian infrastructure has spread to conflicts around the world, and what she's asking AI companies to do that no one has figured out yet.

Visit the Rapid Response website here: https://www.rapidresponseshow.com/

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Brené Brown & Reid Hoffman on the skills every leader needs now Sep 17, 2026

Show notes

Author and researcher Brené Brown joined host Reid Hoffman on stage last year in San Francisco for the 2025 Masters of Scale Summit. She reveals insights about how to lead courageously, the underrated skills leaders need to thrive, and why compassion is essential for success – even if it’s currently being crowded out of the zeitgeist.

For more conversations like this, join us at this year’s Masters of Scale Summit, coming up October 20-22 in San Francisco.

Go to masters of mastersofscale.com/summit to learn more.

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"Strong Ground": https://brenebrown.com/book/strong-ground/

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