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    Health & Fitness

    Luminous: A Podcast about the Science, Philosophy and Culture of Psychedelics

    Are you ready for the psychedelic revolution? Researchers are developing novel treatments for depression, PTSD and addiction, while biotech companies are racing to patent new psychedelic drugs. But for all the headlines, many questions still swirl around this psychedelic renaissance. Why do hallucinogens have such a remarkable capacity to transform lives? Is healing driven by the mind-bending experience itself — or by molecules rewiring the brain? Psychedelics also raise profound questions about the nature of consciousness and mystical experience. Are these simply hallucinations, or do they reveal something profound about the mind — or even about reality itself?

    “Luminous” explores these questions through in-depth, intimate conversations with leading scientists, philosophers, historians and healers. Some episodes examine groundbreaking research. What happens to an octopus on MDMA? Why do psychedelics ease our fear of death? Other episodes venture into the trippier reaches of psychedelic culture and history. One week we might uncover the hidden history of ancient sacred ceremonies. Another week we’ll meet a psychonaut pushing his mind to the outer limits — or rediscover Timothy Leary’s “acid queen.” 

    Originally, these interviews aired on “To The Best Of Our Knowledge,” the Peabody Award-winning Wisconsin Public Radio show that Steve co-founded with Anne Strainchamps. They eventually grew into the spinoff podcast “Luminous.”

    Today, “Luminous” has a new home at Wonder Cabinet Productions, produced in partnership with the University of Wisconsin–Madison’s Center for Psychedelic Research and Education with support from Usona Institute, a nonprofit medical research organization. This partnership reflects Madison’s emergence as one of the world’s most innovative psychedelic centers and marks a new chapter for “Luminous” as we continue to explore the science, philosophy and lived experience of psychedelics.

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    Copyright: Wisconsin Public Radio ©️ 2023

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    Latest Episodes:
    Reclaiming the Acid Queen Nov 08, 2025
    Show notes

    We all know Timothy Leary, the high priest of ‘60s psychedelia, but his partner, Rosemary Woodruff Leary, has largely been forgotten. She also had a remarkable life, even breaking Leary out of prison with the help of the Weather Underground. Now, biographer Susannah Cahalan tells her story — from the heady Sixties to a life on the run for decades.

    —

    00:00:00 Introduction
    00:05:40 Before Timothy Leary
    00:10:40 Millbrook
    00:20:00 Prison Break and Exile
    00:36:00 Twenty Years as an Innkeeper

    —

    • Bio: Susannah Cahalan
    • Book: "The Acid Queen: The Psychedelic Life and Counterculture Rebellion of Rosemary Woodruff Leary"

    Thomas Metzinger on a 'Culture of Consciousness' Aug 02, 2025
    Show notes

    Thomas Metzinger is a renowned German philosopher. He has a longtime fascination with psychedelics, stemming from his own experience and also from his work as an analytic philosopher. He says altered states of consciousness give us profound insights into the nature of the mind. And he believes modern society has an ethical imperative to foster a “culture of consciousness.”

    —

    00:00:00 Introduction
    00:03:10 Is There Knowledge in These States
    00:06:55 Metzinger's Own Experiences
    00:19:45 When It Backfires
    00:28:15 A Concrete Proposal

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    • Bio: Thomas Metzinger

    Marcelo and Kari Gleiser on tripping with your partner May 09, 2025
    Show notes

    Most psychedelic stories are highly personal, but there’s a different dynamic when two people share the experience — especially a married couple. Steve talks with theoretical physicist Marcelo Gleiser and clinical psychologist Kari Gleiser about their transformative experiences.

    —

    00:00:00 Introduction
    00:08:45 A Physicist's First Journey
    00:17:30 Reattaching Mind and Body
    00:26:15 Kari's Clinical Practice
    00:44:00 What a Shared Trip Opens Up

    —

    • Bio: Marcelo Gleiser
    • Bio: Kari Gleiser

    Chris Timmerman on how DMT can deconstruct the mind Mar 01, 2025
    Show notes

    Chris Timmerman is a neuroscientist with a deep interest in phenomenology—what’s actually happening in our minds during psychedelic experiences. He leads the DMT Research Group at Imperial College, where he’s found that a single psychedelic experience can transform a person’s belief system, often turning materialists into panpsychists. In this wide-ranging conversation, Steve talks with Chris about everything from fractals and ayahuasca ceremonies to whether scientists who study psychedelics should talk openly about their own experiences.

    —

    00:00:00 Introduction
    00:06:40 Why Study Non-Ordinary States
    00:16:05 What DMT Does to the Brain
    00:29:15 Entities and Scientific Caution
    00:49:40 The Questions Still Open

    —

    • Bio: Chris Timmermann

    Spring Washam, the Buddhist Shaman Jan 25, 2025
    Show notes

    Buddhist meditation and psychedelic journeys have a lot of shared DNA—both take you deep inside your mind and can change your life. But many Buddhists say psychedelics violate the prohibition against intoxicants. Do they? Spring Washam straddles this divide as both a Buddhist teacher and founder of an ayahuasca church. Her own story is fascinating—how she’s merged these two practices.

    —

    00:00:00 Introduction
    00:03:30 Finding Buddhism in Oakland
    00:12:55 When the Boat Cracked
    00:25:10 Two Traditions, Both True
    00:42:05 A Church in Georgia

    —

    • Bio: Spring Washam

    Do psychedelics reveal a deeper dimension of reality? Nov 30, 2024
    Show notes

    There’s a huge question swirling around the really big psychedelic experiences. Are these mind-blowing trips just hallucinations – the brain shot full of chemicals, playing tricks on you - or do they crack open some transpersonal dimension of consciousness? Most scholars who study psychedelics won’t go anywhere near this question, and yet it’s central to how you interpret these experiences. If you’re in psychedelic-assisted therapy, you want to know if this glimpse of the divine was real or just some figment of your imagination. Philosopher Peter Sjöstedt-Hughes believes we need a metaphysics of psychedelics to explain these powerful experiences.

    —

    00:00:00 Introduction
    00:04:05 A Metaphysics of Psychedelics
    00:19:55 The Comforting Delusion Objection
    00:29:15 Problems with the MEQ

    —

    • Bio: Peter Sjöstedt-Hughes

    Katherine MacLean on the Limits of Consensus Reality Aug 31, 2024
    Show notes

    “Psychedelic people are practicing at the very edge of anyone else’s comfort zone,” says psychologist Katherine MacLean, author of the psychedelic memoir “Midnight Water.” MacLean was a pioneering psychedelic researcher at Johns Hopkins, who then left her job to pursue her own unconventional psychedelic journey. She talks with Steve Paulson about her work as a psychedelic guide, her personal history with psychoactive substances, and why she reveres the Mexican healer Maria Sabina.

    —

    00:00:00 Introduction
    00:01:20 Recovering Maria Sabina
    00:14:05 Dartmouth to Johns Hopkins
    00:23:05 When the Trips Got Harder
    00:42:10 A Vigil for Her Father

    —

    • Bio: Katherine MacLean

    Erik Davis on LSD and the Psychedelic Underground Jul 20, 2024
    Show notes

    Erik Davis’ “Blotter” is really three books in one: It’s about the way LSD tabs were embedded in blotter paper so they wouldn’t be detected by the authorities; it’s also a deep dive into the psychedelic underground; and finally, it’s an art book — gorgeously illustrated, with lots of very trippy blotter art. Steve talks with Erik about the wildness of psychedelic experiences and whether they reveal a deeper dimension of consciousness.

    —

    00:00:00 Introduction
    00:03:05 What Blotter Actually Is
    00:12:25 Acid Art and Underground Media
    00:18:25 In Defense of Recreation
    00:30:30 High Weirdness and Reality

    —

    • Bio: Erik Davis

    Did the ancient Greeks use drugs to find God? May 04, 2024
    Show notes

    Brian Muraresku makes the controversial argument that the famous Eleusinian Mysteries were fueled by a psychedelic wine. And he speculates that this secret ceremony, with its mind-altering drugs, became the Eucharist — the foundational event of early Christianity.

    —

    00:00:00 Introduction
    00:06:35 A Catholic Who Won't Partake
    00:09:50 The Mysteries at Eleusis
    00:23:30 Kykeon, Ergot and the Evidence
    00:29:30 The Eucharist and the Vatican

    —

    • Bio: Brian Muraresku

    A brief history of getting high Jan 27, 2024
    Show notes

    It’s remarkable how fast psychedelics have gone mainstream. Just look at how so many major universities are racing to set up their own psychedelic institutes. Psilocybin and MDMA are now considered the most promising treatments for depression and PTSD that we’ve had in decades. But this is not the first time psychoactive drugs were hailed as miracle cures. Heroin and cocaine were also once considered wonder drugs. Today, what’s so striking is how the public conversation about psychedelics ignores this deeper history of intoxicants.

    British historian Mike Jay wants to challenge this narrative of psychedelic “exceptionalism.” In his book “Psychonauts: Drugs and the Making of the Modern Mind,” he digs into the 19th century’s rich history of psychoactive experiences — and tells the story of seminal figures like Humphry Davy, Sigmund Freud and William James – and lots of other people I’d never heard of.

    Jay is also upfront about his own psychedelic experiences. He’s had plenty of them. And he believes the scientists and doctors who study psychedelics should talk more openly about their own mind-altering experiences — which is definitely not the case for most of them.

    —

    00:00:00 Introduction
    00:08:05 The First Psychonauts
    00:20:25 Freud, Cocaine and Ambition
    00:28:35 William James on Nitrous Oxide
    00:38:45 What You Bring Back

    —

    • Bio: Mike Jay
    • Book: "Psychonauts: Drugs and the Making of the Modern Mind"
    • Nautilus: "Why Scientists Need to Get High"

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