Live Long with Peter Bowes

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Erin Sharoni: Optimizing diet and healthspan Feb 23, 2021

Show notes

Nutritional supplementation is one of the most frequently raised topics in relation to longevity and healthy living. But do we really need additional components in our diet, such as pterostilbene , sulforaphane and resveratrol? Scientifically validated studies suggest some dietary supplements are beneficial to our health, but how do we decide which ones to take? There are myriad considerations. To explore the subject, the LLAMA podcast is teaming up with JUVICELL, a nutraceutical product developed by US and German scientists. In this conversation with Peter Bowes, co-founder, Erin Sharoni, discusses the scientific, ethical and societal issues involved in developing a product that aims to extend healthspan.

Recorded: February 15, 2021 | Read a transcript and show notes at the LLAMA podcast website.

The study of epigenetics and what it means. Our internal and external environments and how they interact.
Erin's "obsession" with the human body and how it changes over time.
Does living like an elite athlete help us live longer?
The basic protocols for good health, like sleep, diet and hydration that impact longevity
The most basic lifestyle traits that help us thrive.
Why there is no magic bullet to optimum health.
The insurance policy approach to dietary supplementation.
The power of fasting and the work of Dr. Valter Longo at the university of Southern California (USC).
The idea and mission behind JUVICELL
Why the mission is to help people optimize healthspan rather than lifespan.
Explaining the ingredients that go together to form an all-in-one dietary supplement.
Safety, supplementation and ethical responsibility to follow the science.
Lessons from the Covid pandemic and the big changes needed at a societal level to enable healthier populations.
Sleep, whole foods, meditation and other lifestyle components to promote every day health and longevity.

This episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by scientific studies. To find out more, visit juvicell.com

The Live Long and Master Aging podcast shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

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The Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Julie Andersen: Could better gut health help prevent Alzheimer's? Feb 15, 2021

Show notes

Cognitive decline is an all-too-familiar hallmark of age-related diseases, such as Alzheimer's and Parkinson's. While there is much research that focuses exclusively on functional changes in the brain, the so-called gut-brain axis - a connection between the digestive system and the central nervous system - also appears to play a pivotal role. It raises the question: Could nutritional interventions, to nurture the health of the gut microbiome, also help prevent or reverse age-related dementia? In 2018, Dr. Julie Andersen, a scientist at the Buck Institute for Research On Aging, in California, received a $3.8 million grant to explore the hypothesis. In this LLAMA podcast episode, Dr. Andersen discusses the work of her laboratory, and the idea that a gut metabolite, urolithin A, could play an important role in the treatment of Alzheimer's disease.

Recorded: February 9, 2021 | Read a transcript and show notes at the LLAMA podcast website.

Topics covered in this interview include:

Working at the Buck Institute for Research On Aging - the only freestanding institute studying aging and age-related disease.
A multi-disciplinary approach to aging research, embracing a range of diseases and mechanisms that drive-age related conditions.
Evolving definitions of aging.
Exploring autophagy, mitochondrial function, urolithin A and muscle health, in relation to Parkinson's and Alzheimer's disease.
The science and logic behind restoring an older person's gut microbiome to that of a younger person.
Building on "exciting" clinical trials, by Amazentis, looking at the efficacy, in older humans, of Urolithin A, to enhance muscle function.
Exploring the relatively new area of study known as the gut-brain axis.
Explaining the scientific process, grants and clinical trials.
How preliminary preclinical trial data suggests urolithin fed to mice may prevent cognitive loss associated with Alzheimer's disease.
Turning 60 and aspirations for a long healthspan.

This episode is brought to you in association with Amazentis, a Swiss life science company, that is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.
Related episodes:

David Katz: Robust health beyond the pandemic
Stuart Phillips: Boosting physical strength as we age
Stephanie Blum: Embracing and marketing the science of wellbeing
Johan Auwerx: Enjoying youthful vitality as we age
Navindra Seeram: The rejuvenating power of plants
Patrick Aebischer: A novel molecule to promote longevity
Anurag Singh: Pomegranates, muscle mass and healthy aging

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Alison Weinlaeder: Melding mind and muscle Feb 04, 2021

Show notes

When the pandemic struck, instead of hunkering down, with her life on hold, Alison Weinlaeder moved into top gear with her brain-child, a new online business melding physical and mental workouts. The speech-language pathologist, from Saint Paul, Minnesota, wanted to help people improve their cognitive abilities, at the same time as nurturing their cardiovascular fitness. Cardiomelon is a fitness program that puts the essential components of daily health at its core. In this LLAMA podcast interview with Peter Bowes, Alison explains the science behind her novel approach to fitness. She also shares the challenges and rewards she enjoys through a startup focussed on helping people live longer and better.

Recorded: January 22, 2021 | Read a transcript and show notes at the LLAMA podcast website.

This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.com

Topics covered in this interview include:

Why we should work on keeping the brain healthy and strong as well as the body
Working, as a speech language pathologist, with people who've experienced tragic and traumatic events
Pushing the brain outside its comfort zone
The challenged posed by virtual therapy for patients with severe brain injuries
Launching Cardiomelon in the midst of a pandemic
Isn't it just normal to forget things as we get older?
Empowering people through brain-focussed exercise
How gardening and walking can help boost brain performance.
Building a brain workout programme based on the concepts of rehabilitation - the principles of neuroplasticity
Why you've got to use it to improve it
Why just doing mental workouts, without always succeeding in a challenge, will improve brain health
Never too late or early to start.
Partnering with Hilarity for Charity with a mission to educate people in their 20s about poor health habits that could lead to Alzheimer's
The evidence to support combining cognitive and physical exercise
Learning how to think smarter, through visualization and habits
Being empowered to control brain health
The lifestyle habits that will determine how our lives will be like, decades in the future.
Future science-based research into the outcomes from Cardiomelon

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Leslie Kenny: Biohacking and spermidine for life-enhancement Jan 27, 2021

Show notes

After a diagnosis of lupus, in her 30s, Leslie Kenny was told she had a life expectancy of five years. The prognosis focussed the Berkeley and Harvard grad's mind like never before. Long before biohacking was a thing, Leslie set about changing her lifestyle, embracing safe, natural solutions, in a fight for her life. Now 56, she is aging well, healthy and a fully signed up biohacker. She is the founder of Oxford Healthspan, a UK-based company, working with leading scientists to identify safe compounds as nutritional supplements. In this LLAMA podcast conversation with Peter Bowes, Leslie discusses her own unique journey, as well as the science and life-enhancing potential of spermidine, a compound that has been shown to be vital to myriad bodily functions.

Recorded: January 19, 2021 | Read a transcript and show notes at the LLAMA podcast website.

Topics covered in this interview include:

Leslie's journey from Swiss banking to biohacking
Facing up to Lupus and a five-year life expectancy
One's own mortality and the limits of longevity
Pillars of preventative healthcare: sleep, movement , diet, friendship, family
Why your health is your wealth
Discovering the polyamine compound spermidine and establishing Oxford Healthspan
Where does the name spermidine come from and what is it?
The evidence for the benefits of spermidine - epidemiological studies and clinical trials
Is spermidine supplementation safe?
How do consumers make decisions about which supplements to take?
Living life with the promise of healthspan rather than lifespan
Disease prevention versus disease care
The lifestyle of a biohacker - sleep hygiene, good food, lowered stress

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Cathy Richards: Fit or frail at eighty-five? Jan 18, 2021

Show notes

It is often said that it is never too late to adopt a healthy lifestyle - never too late to incorporate more exercise into our daily routine or focus on a healthier diet, to reap the rewards as we age. In reality, a message that it is never too early to focus on our wellbeing and longevity, is equally important. Perhaps more so. Cathy Richards is an exercise physiologist and founder of Inspiring Vitality, an online coaching program focussing on the needs of people over 40. In this LLAMA podcast interview with Peter Bowes, Cathy discusses her mission to encourage more people to take steps - even tiny steps - in their daily lives, to incorporate strength building activity into their routines. She also highlights the significance of deteriorating hearing for overall health and the likelihood that impaired hearing can lead to social isolation and loneliness.
Recorded: January 11, 2021 | Read a transcript and show notes at the LLAMA podcast website.

Topics covered in this interview include:

Adapting to a new way remote way of working out during and likely after Covid
Learning about the behavioral trail of very old populations and joining the longevity dots
The onset of frailty and the snowball effect of muscle decline
Implementing resistance training into exercise regimes to maintain muscle strength
Doing the bare minimum exercise to still realize significant result.
Small, step and changes that add up and make a difference over time
Persuading younger generations that it is never too early to think about being fit at 85.
Hearing loss and the impact on our quality life as we age
The stigma associated with hearing loss and dangers
The correlations been hearing loss and dementia.
Social isolation, poor hearing and loneliness.
Personal habits to live a healthy day
Sleep as a wellness trend

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Chip Conley: Wisdom, curiosity and the modern elder Jan 08, 2021

Show notes

As we push the boundaries of human longevity and our expectations for lifespan, mid-life is going to be different. Our healthy, vibrant decades are being extended. The goal of enjoying more fulfilling years, free of diseases and physical decline is becoming a reality. The trajectory of our lives is changing. Chip Conley is a veteran executive in the hospitality industry, formerly Head of Global Hospitality and Strategy with Airbnb and a prolific writer. He's also the founder of the Modern Elder Academy, a self-styled school for midlife wisdom and the author of Wisdom@Work: The Making of a Modern Elder. In this conversation with Peter Bowes, Chip shares his vision of older people as wise, curious and indispensable members of society. He recalls the impact of a near-death experience, the way his life went through a transformation in his 50s and the art of lifelong learning.

Recorded: December 29, 2020 | Read a transcript and show notes at the LLAMA podcast website.
Photo credit: Lisa Keating
This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.com
Topics covered in this interview include:

Chip's life-defining brush with death and experience of going to the "other side" during a medical emergency.
Doing business as a "hospitality disrupter," as one of the first boutique hoteliers and later with Airbnb.
Creating the Modern Elder Academy (MEA), mid-life wisdom school.
What is long-life learning?
The unexpected pleasures of aging.
Focussing on "great longevity" and a spiritual diet.
Upgrading the human operating system - moving from reverence to relevance as a "modern elder."
Launching the MEA - a regenerative community - a 21st century version of a retirement community.
Taking the less traveling path in life.
Having regrets or no regrets in life?
Metabolizing and cultivating wisdom from life's experiences.
Acknowledging and challenging "new year resistances" fears and old habits.
Role models for a living a very long life.
Embracing curiosity as tool to live a long life.

The Live Long and Master Aging (LLAMA) podcast is a HealthSpan Media LLC production. LLAMA shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

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Nichola Conlon: Stimulating the body to repair itself Dec 30, 2020

Show notes

The body's unique ability to repair itself, with a little outside help, is the focus of a growing sphere of longevity science. One area of research concerns a molecule, known as nicotinamide adenine dinucleotide (NAD+), which plays a key role in many biological processes. NAD+ declines as we age, but research has shown that, through supplementation, youthful levels can be restored, helping us to age better.

In this episode, Dr Nichola Conlon, a molecular biologist and co-founder of Nuchido Laboratories, based in North -East England, discusses her mission to develop nutraceuticals to stimulate rejuvenation.
In conversation with Peter Bowes, Nichola explains her passion for nutritional interventions designed to enhance healthspan; she addresses the need to educate people about the relevance of biogerontology research and the new products that could significantly improve our quality of life.

Recorded: December 3rd, 2020 | Read a transcript and show notes at the LLAMA podcast website.
“This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.com
Topics covered in this interview include:

A career in science driven by Nichola's fascination with the human body - how "it's so intricately designed and perfect to make us tick."
How do drugs work - from consumption to the cells where they need to work.
What is aging?
The steep learning curve involved in aging research.
Is it a good thing to try to slow aging and should it be done through supplementation?
Translating the science into consumer products.
What does Nuchido mean?
Explain the role and complexities of NAD+
The benefits of elevated NAD levels, related to aging.
Why reverse a process (declining NAD) when it appears to be a natural part of aging?
Why we are very good at being young but not so good at being old.
Being a successful female scientist and entrepreneur in a male-dominated world.
The importance of tracking your own health through regular blood tests.
Why the sky's the limit in biogerentology.

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Cheryl Ladd: Charlie's Angels star acting her age with optimism Dec 15, 2020

Show notes

Optimism, during this tumultuous year, has been in short supply. But as 2021 beckons, there is a real sense of hope that happier, healthier times are ahead. Cheryl Ladd, best known for her role in the 1970s detective series, Charlie's Angels, is also emerging from a rollercoaster of a year. As well as dealing with the emotional challenges presented by Covid-19, for the first time in her life, the actress says she started to feel old. But it was the challenge of failing eyesight that motivated her to take on a new mission in life, encouraging others, with optimism and gratitude, to embrace the aging process. In this LLAMA podcast interview with Peter Bowes, the 69-year old explains why wellness matters; how she has overcome cataracts with new technology; her reluctance to retire and future aspirations in Hollywood.
Recorded: September 17th, 2020 | Read a transcript and show notes at the LLAMA podcast website.
“This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.com
Topics covered in this interview include

The rocket ship that was Charlie's Angels and a 44-year career
Mastering the process of growing old with optimism
Dark times through isolation during the pandemic
The healing power of a hug
Appreciating what we have and expressing gratitude
I'm 69-years old. How did this happen?
Changing sleep patterns as we age.
Appreciating what we have and expressing gratitude
Dealing with eye cataracts and a fear of driving at night
What is there to love about life and keep living for?
Retirement or not?
Being old and female in Hollywood.

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David Katz: Robust health beyond the pandemic Dec 09, 2020

Show notes

If the coronavirus pandemic has reminded us of anything, it is that there is nothing more important than our health and wellbeing. Now that the vaccine is a reality for people in the UK - and the rest of the world soon - there is real hope that the disease will be brought under control during the first part of next year.
"People in robust good health are massively less vulnerable to bad outcomes during the pandemic and more vital in general," says Dr. David Katz, a physician and co-author of the new book, How to Eat. Highlighting the importance of lifestyles and nutritional interventions, to promote health and vitality, Dr Katz says, there is much to be done tackling the "neglected scourges” of modern living, as we move on from the pandemic.
A renowned public health commentator and prolific writer, Dr Katz serves on the Scientific Advisory Board of Amazentis, a Swiss life science company and co-producer of this LLAMA podcast episode. In this interview, with Peter Bowes, he analyzes the current state of Covid-19; the challenge of sorting fact from fiction; the prospect of “herd immunity” and life after the virus. He also delves into the infinitely fascinating world of the microbiome and nutritional products that promote enhanced muscle mass and function as we age.
Recorded: December 1st, 2020 | Read a transcript and show notes at the LLAMA podcast website.
This episode of the LLAMA podcast was brought to you in association with Amazentis, a Swiss life science company, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.

Topics covered in this interview include

How a rambunctious kid chose a career in medicine and developed a passion for preventing chronic disease, and promoting health.
Analyzing the lifestyle practices that determine our state of health.
Drama over data and the Covid-19 pandemic.
What does herd immunity mean?
Pandemic fatigue, opening up society and phasing back to normalcy.
The "acute case for chronic health" as we emerge from the pandemic.
Mitochondrial health, the microbiome, pomegranates and urolithin A.
Amazentis' nutritional product Mitopure and clinical trials suggesting a positive impact on physical stamina and endurance.
Can rejuvenation of mitochondria mimic the health of the world's fittest communities?
Sleep, diet and exercise.

Related episodes

Stuart Phillips: Boosting physical strength as we age
Stephanie Blum: Embracing and marketing the science of wellbeing
Johan Auwerx: Enjoying youthful vitality as we age
Navindra Seeram: The rejuvenating power of plants
Patrick Aebischer: A novel molecule to promote longevity
Anurag Singh: Pomegranates, muscle mass and healthy aging

Fit, Healthy & Happy Podcast
Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...

Listen on: Apple Podcasts Spotify

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Nir Barzilai: Is aging, as we know it, over? Nov 29, 2020

Show notes

The concept of healthspan - the number of years that we enjoy optimum health - has come a long way, in recent years. In fact, Dr. Nir Barzilai, founding director of the Institute for Aging Research at Albert Einstein College of Medicine, believes we are "ushering in a future where the norm will be for people to be healthy, active and mentally sharp, during the last quarter of their lives." In his new book, Age Later: Healthspan, Life Span, and the New Science of Longevity, he argues that aging can be "targeted, improved and even cured," and that it should be thought of as not "as a certainty but as a phenomenon." In this LLAMA podcast episode, with Peter Bowes, Dr Barzilai, discusses his life's work studying some of the world's super agers, people who are enjoying active and productive lives well into their nineties and beyond.
Recorded: September 21st, 2020 | Read a transcript and show notes at the LLAMA podcast website.

Topics covered in this interview include:

Dr Barzilai's lifelong interest in longevity and healthspan
The impact of Covid 19 and why it has highlighted issues surrounding agism.
Post-covid and finding the right balance with social interactions.
The TAME (Targeting Aging with Metformin) study and wider uses for the anti-diabetic drug, relating to aging, coronavirus and cancer.
Should we all be taking metformin? The ethical dilemmas.
Why "flexible" biology of aging.
What has been learned through the study of 750 centenarians?
Learning lessons from Frieda - the grandmother of Dr. Barzilai's wife.
Why we should not put off our dreams.
The longevity dividend.
Caloric restriction, fasting and time-restricted eating.
Getting enough sleep.

Earlier LLAMA podcast in with Dr. Barzilai: Researching the genetics of exceptional longevity and drugs that could target aging

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