Joint Approach

Innovative Approaches to Bone and Joint Infections Part 1 Sep 09, 2025

Host Jessica Seidelman, MD has an in-depth discussion with Kerry LaPlante, Pharm.D., FCCP, FIDSA, FIDP, and Julie Ann Justo, Pharm.D. in the opening episode of this 3-part series. They discuss why PJI infections are so difficult to treat, and advances in antimicrobial agents in the pipeline. This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at BONESUPPORT.com

Listen to Breakpoints: The SIDP Podcast

References:

“Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection” PMID 34042388

“NDM-9 resistance to taniborbactam” PMID 36796395

“Wide dissemination of Gram-negative bacteria producing the taniborbactam-resistant NDM-9 variant: a One Health concern” PMID 37394537

IDSA 2024 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

“Dalbavancin for the Treatment of Osteomyelitis in Adult Patients: A Randomized Clinical Trial of Efficacy and Safety” PMID 30648126

“Corynebacterium striatum Prosthetic Joint Infection Successfully Treated with Long-Term Dalbavancin” PMID 36985124

“Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a Patient Treated with Dalbavancin: Case Report and Isolate Characterization” PMID 35510938

“Local antibiotic delivery via intra-articular catheter infusion for the treatment of periprosthetic joint infection: a systematic review” PMID 38691147

“A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model” PMID 26833157

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Bugged and Baffled: Case 2 with Jenny Aronson Aug 19, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD in this Case Study Series entitled Bugged and Baffled. In this episode, they discuss another challenging case with Jenny Aronson, MD. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Bugged and Baffled: Case 1 with Jenny Aronson Aug 05, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD in this Case Study Series entitled Bugged and Baffled. In this episode, they discuss a the first of two challenging cases with Jenny Aronson, MD. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Megaprostheses Part 2 Jul 22, 2025

Jessica Seidelman, MD, and Johannes Plate, MD. PhD conclude this discussion on the role of the Megaprosthesis in oncological indications with Juan Pretell, MD and Santiago Lozano-Calderon, MD, PhD. Thanks to Osteal Therapeutics for sponsoring this episode. For more information about VT-X7, including the APEX clinical trials results, please visit Ostealtx.com

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Megaprostheses Part 1 Jul 08, 2025

Jessica Seidelman, MD, and Johannes Plate, MD, PhD host Juan Pretell, MD and Santiago Lozano-Calderon, MD, PhD as they discuss the role of the Megaprosthesis in oncological indications. Thanks to Osteal Therapeutics for sponsoring this episode. For more information about VT-X7, including results from the APEX clinical trials, please visit Ostealtx.com

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Bugged and Baffled: A Case with Alaina Ritter and Minu Abraham Jun 24, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD in this Case Study Series entitled Bugged and Baffled. In this episode, they discuss a challenging case with Alaina Ritter, MD, and Minu Abraham, MD. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Bugged and Baffled: A Case with Jakrapun Pupaibool Jun 10, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD in this Case Study Series entitled Bugged and Baffled. In this episode, they discuss a challenging case with Jakrapun Pupaibool, MD, MS. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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PJI- Patient Perspective Part 2 May 20, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they conclude the discussion, Patient Perspectives of PJI with William Jiranek, MD, and James Campbell, who is a registered nurse, a vascular access specialist, and a prosthetic joint infection survivor. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

PJI - Patient Perspective Part 1 May 06, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they discuss Patient Perspectives of PJI with William Jiranek, MD, and James Campbell, who is a registered nurse, a vascular access specialist, and a prosthetic joint infection survivor. Stay tuned for the conclusion of this series. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Bugged and Baffled: A Case with Andy Miller Apr 15, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD in this new Case Study Series entitled Bugged and Baffled. In this episode, they discuss a challenging case with Andy Miller, MD, Current President of MSIS, and Chief of Infectious Diseases at HSS. Spoiler alert- this case has just been published in JBJS and can be found at this link to the article. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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Persistent and Challenging Orthopedic Infections: Biofilm Part 2 Apr 01, 2025

Hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD conclude this discussion onBiofilm with Ken Urish, MD, and Alexander Tatara, MD. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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Persistent and Challenging Orthopedic Infections: Biofilm Part 1 Mar 18, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they have an engaging discussion on Biofilm with Ken Urish, MD, and Alexander Tatara, MD in part 1 of this 2 part series.

Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Shoulder PJI Part 2 Mar 04, 2025

Hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD conclude this discussion on shoulder periprosthetic joint infections with Mark Cullen, MD, Bryan Crook, MD and Christopher Klifto, MD. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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Shoulder PJI Part 1 Feb 18, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they discuss shoulder periprosthetic joint infections with Mark Cullen, MD, Bryan Crook, MD and Christopher Klifto, MD in part 1 of this 2 part series. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Diabetic Foot Infections Part 2 Feb 04, 2025

Hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD conclude this discussion on diabetic foot infections with Kyle Wamelink, DPM and Marcos Schecter, MD. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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Diabetic Foot Infections Part 1 Jan 21, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they discuss diabetic foot infections with Kyle Wamelink, DPM and Marcos Schecter, MD in part 1 of this 2 part series. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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Dental Prophylaxis for Patients Who Have Undergone Total Joint Arthroplasty Jan 07, 2025

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they discuss dental prophylaxis with Elie Berbari, MD, MBA and Charles Hannon, MD, MBA.

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Fracture Related Infections Part 2 Dec 17, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they conclude the conversation with Alaina Ritter, MD, and Malcolm DeBaun, MD about Fracture Related Infections. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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Fracture Related Infections Part 1 Dec 03, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they talk with Alaina Ritter, MD, and Malcolm DeBaun, MD in Part 1 of this discussion on Fracture Related Infections. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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One and Done or Two to Tango? 1 vs. 2-Stage Procedures for the Treatment of PJI Part 2 Nov 19, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they conclude the conversation with Professor Fares Haddad, MBBS MD, MCh, FRCS FFSEMMD, and Thomas Fehring, MD about one-stage vs. two-stage revision with PJI. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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One and Done or Two to Tango? 1- vs. 2-Stage Procedures for the Treatment of PJI Part 1 Nov 05, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they talk with Professor Fares Haddad, MBBS MD, MCh, FRCS FFSEMMD, and Thomas Fehring, MD about one-stage vs. two-stage revision to treat PJI. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here .

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Plasma Microbial Cell-free DNA Next-generation Sequencing can be a Useful Diagnostic Tool in Patients with Osteoarticular Infections Oct 22, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Francesco Petri, MD chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD.

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Evaluating the Safety and Efficacy of Low-dose Chlorhexidine Gluconate Irrigation for Open Fracture Management Oct 15, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Jaclyn Jankowski, DO chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD.

Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

Complete Eradication of Biofilm Using Low Frequency Electromagnetic Force (EMF) and Antibiotics at MIC Oct 08, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Gerhard Maale, MD chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD.

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Suppressive Antibiotic Therapy in Patients With Prosthetic Joint Infection and Retained Hardware: How Much is Enough? Oct 01, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Marjorie Golden, MD chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please click here

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A Novel Isotropic Optical Fiber: Antimicrobial Effect of Blue Light on Drug Resistant Organisms Sep 24, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Antonia Chen, MD chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD. Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

Unsupervised Machine Learning Can Group Synovial Fluid Samples into Disease-Relevant Clusters: AI Diagnosis is Near! Sep 17, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Carl Deirmengian, MD chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD.

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The Comparative Analysis of 1.5-Stage and 2-Stage Revision for Periprosthetic Infection after Total Hip Arthroplasty. Is 1.5-Stage Really Equivalent? Sep 10, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Carlos Higuera, MD chats with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD.

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The Timing of Acute Periprosthetic Joint Infection of Total Knee Arthroplasty does not affect failure rates for DAIR Sep 03, 2024

In this episode from the Musculoskeletal Infection Society 34th Annual Open Scientific Meeting, Ken Urish, MD, PhD chats about his research with hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD. Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please visit Biocomposites.com

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Oral Antibiotics Part 2 Aug 27, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they conclude the discussion with Marjan Wouthuyzen-Bakker, MD, and Nicolas Cortes-Penfield MD on oral antibiotics to treat bone and joint infections.

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Oral Antibiotics Part 1 Aug 20, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they talk with Marjan Wouthuyzen-Bakker, MD, and Nicolas Cortes-Penfield MD about using Oral Antibiotics to treat bone and joint infections.

This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at bonesupport.com

FOLLOW us on X @jointapproach or Instagram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

Bacteria Phages and How They Can Be Used to Treat Bone and Joint Infections Part 2 Aug 06, 2024

In the conclusion of this series, hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD finish the discussion with Ken Urish, MD, PhD and Gina Suh, MD about Bacteria Phages and their use in treating bone and joint infections.

This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at BONESUPPORT.com

FOLLOW us on X (formerly twitter) @jointapproach or Instagram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

Bacteria Phages and How They Can Be Used to Treat Bone and Joint Infections Part 1 Jul 16, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they talk with Ken Urish, MD, PhD and Gina Suh, MD about Bacteria Phages and their use in treating bone and joint infections in this two part series. This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at bonesupport.com

FOLLOW us on X (formerly twitter) @jointapproach or Instagram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

Surgical Site Infection Prevention Part 3 Jul 02, 2024

In this final episode of the Surgical Site Infection Prevention series, Jessica Seidelman, MD and Johannes Plate, MD, PhD conclude their discussion with Tobias Kramer, PD Dr. med, MSc and Keith Kaye, MD, MPH. This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at bonesupport.com

FOLLOW us on X @jointapproach or Instagram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

Surgical Site Infection Prevention Part 2 Jun 18, 2024

Listen in to part 2 of this 3 part series as hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD continue their discussion with Tobias Kramer, PD Dr. med, MSc and Keith Kaye, MD, MPH about Surgical Site Infection Prevention.

Thanks to Irrisept for sponsoring this episode. For more information about Irrisept products, please click here.

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Surgical Site Infection Prevention Part 1 Jun 04, 2024

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD as they talk with Tobias Kramer, PD Dr. med, MSc, and Keith Kaye, MD, MPH about Surgical Site Infection Prevention in this three part series.

Thanks to Biocomposites for sponsoring this episode. For more information about Biocomposites products STIMULAN®, NanoBone®, and genex®, please visit: https://biocomposites.com/

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Conversations from the 33rd Annual Open Scientific Meeting: Ryan Khodadadi Mar 28, 2024

Dr. Ryan Khodadadi chats with Drs. Jessica Seidelman and Johannes Plate about pre-op antibiotic therapy for diagnosis of native joint septic arthritis.

To see the abstract, listen in the free ConveyMED app: Apple Store or Google Play.

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Conversations from the 33rd Annual Open Scientific Meeting: Gabriel Linden Mar 26, 2024

Dr. Gabriel Linden chats with Drs. Jessica Seidelman and Johannes Plate about risk factors for repeat irrigation and debridement in native joint septic arthritis.

To see the abstract, listen in the free ConveyMED app: Apple Store or Google Play

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Conversations from the 33rd Annual Open Scientific Meeting: Marjorie Golden Mar 21, 2024

Dr. Marjorie Golden chats with Drs. Jessica Seidelman and Johannes Plate about care signature pathways best practices.

To see the abstract, listen on the free ConveyMED app: Apple Store or Google Play

FOLLOW us on X (formerly twitter) @jointapproach or Instagram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

Conversations from the 33rd Annual Open Scientific Meeting: Geno Tai Mar 19, 2024

Dr. Geno Tai chats with Drs. Jessica Seidelman and Johannes Plate about his antimicrobial suppression study in 3 countries.

To see the abstract, listen in the free ConveyMED app: Apple Store or Google Play

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Conversations from the 33rd Annual Open Scientific Meeting: Emily Treu Mar 14, 2024

Dr. Emily Treu chats with Drs. Jessica Seidelman and Johannes Plate about "Dry Tap" diagnostics in Total Hip Arthroplasty.

To see the abstract, listen in the free ConveyMED App: Apple Store or Google Play

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Conversations from the 33rd Annual Open Scientific Meeting: Irene Sigmund Mar 12, 2024

Dr. Irene Sigmund chats with Drs. Jessica Seidelman and Johannes Plate about observations between European and US intervention for orthopedic infections.

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Conversations from the 33rd Annual Open Scientific Meeting: Douglas Chonko Mar 07, 2024

Dr. Douglas Chonko chats with Drs. Jessica Seidelman and Johannes Plate about Biofilm in Periprosthetic Joint Infections.

To see the abstract, listen in the free ConveyMED Podcast App: Apple Store or Google Play

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Conversations from the 33rd Annual Open Scientific Meeting: Benjamin Levy Mar 05, 2024

Dr. Benjamin Levy chats with Drs. Jessica Seidelman and Johannes Plate about cutibacterium in THA and TKA.

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To see the abstract, listen on the free ConveyMED App: Apple Store or Google Play

Conversations from the 33rd Annual Open Scientific Meeting: Hussam Tabaja Feb 29, 2024

Dr. Hussam Tabaja chats with Drs. Jessica Seidelman and Johannes Plate about fracture related infections.

To see the abstract, listen in the free ConveyMED app: Apple Store or Google Play

FOLLOW us on X (formerly twitter) @jointapproach or instragram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

Conversations from the 33rd Annual Open Scientific Meeting: Allison Lastinger and Matthew Dietz Feb 27, 2024

Drs. Allison Lastinger and Matthew Dietz chat with Drs. Jessica Seidelman and Johannes Plate about their collaborative orthopaedic-infectious disease clinic.

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Conversations from the 33rd Annual Open Scientific Meeting: Brian Klatt Feb 22, 2024

Dr. Brian Klatt, past President of MSIS, chats with Drs. Jessica Seidelman and Johannes Plate about the challenges of treating patients with periprosthetic joint infections and the evolution of MSIS over the years and into the future.

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Treatment of Infection with Systemic Antibiotics Sep 26, 2023

Listen in as hosts Drs. Jessica Seidelman and Johannes Plate speak with Professor Parham Sendi about systemic antibiotics for the treatment of bone and joint infections. They discuss treatment of a patient with chronic infection and retained hardware. FOLLOW us on twitter @jointapproach or instragram @jointapproachpodcast for more announcements and content, and reach out to us at jointapproachpodcast@gmail.com

How To Take and Interpret Cultures: Part 2: Intraoperative Diagnostics Aug 15, 2023

In the conclusion of this episode on interpreting cell cultures, Drs. Jessica Seidelman and Johannes Plate continue their discussion with Drs. Robin Patel and Martin Clauss focused on intra-operative diagnostics, including:

Techniques to open the joint and take the fluid
Importance of location matter
Number of cultures
Tests to request: fungal and AFB - are these for everyone?
Cell count and intraoperative frozen sections.

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How To Take and Interpret Cultures: Part 1: Pre-operative Diagnostics Aug 15, 2023

Co-hosts Drs. Jessica Seidelman and Johannes Plate chat with Drs. Robin Patel and Martin Clauss about taking and interpreting cell cultures and pre-operative diagnostics including:

Main causes of a culture-negative PJI
Techniques available to help diagnose a PJI when previous standard cultures have been negative
Importance of technique
Kinds of tests
Patient antibiotic management to optimize intraoperative yield.

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Working Together as a Team Aug 11, 2023

Co-hosts Drs. Jessica Seidelman and Johannes Plate talk with Drs. Laura Certain and Rihard Trebse about the perspectives of the Orthopedic surgeon and the Infectious Disease physician and the importance of collaboration to manage patient infections.

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