Into the Impossible With Brian Keating

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Could Biological Robots Heal Us from the Inside? Michael Levin - #525 Oct 28, 2025

Show notes

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What if cells from your own trachea sitting in a petri dish right now, could spontaneously organize into swimming robots that heal brain tissue? What if frog skin cells with no genetic modification whatsoever, could build copies of themselves from spare parts lying around?

This isn't science fiction. This is the work of Michael Levin at Tufts University and is completely rewriting the rules of biology.

Michael Levin's research challenges our fundamental understanding of what life is and where biological properties emerge from. Michael Levin is a distinguished biologist at Tufts University and director of the Allen Discovery Center, whose groundbreaking research on bio electricity and regenerative biology is reshaping our understanding of how biological systems process information and pursue goals.

His Xenobots, living robots built from frog cells, swim around, work together, and reproduce in ways that have never existed on Earth.

What does this tell us about consciousness, intelligence, and the nature of life itself?

KEY TAKEAWAYS

00:00 "Bioelectricity: Nature’s Cognitive Glue"

04:57 Neuronal Voltage Gradients Enable Computation

08:17 Magnetic Fields and Living Systems

11:43 "Voltage, Membranes, and Injury Signals"

14:51 "Bioelectric Properties in Cells"

15:59 Cell Circuits and Networks

19:31 "Ion Drugs Overcome Electrode Limits"

22:53 Asymmetric Features in Living Creatures

26:00 Embryo Symmetry Breaking Mechanism

30:11 "Space-Time Effort and Goal Scope"

33:19 "Origins: Universe and Life"

36:29 Causal Integration and Emergence Insights

42:02 Cell Liberation Enables Autonomous Behavior

43:53 "Xenobots: Self-Replicating Robots"

47:04 "Consciousness, Life, and Intelligence"

Additional resources: Levin Lab https://www.drmichaellevin.org/

Follow Michael on X https://x.com/drmichaellevin?s=21

Michael Levin’s book: https://a.co/d/dzl9wPQ

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📚 Get a copy of my books:

Think Like a Nobel Prize Winner, with life changing interviews with 9 Nobel Prizewinners: https://a.co/d/03ezQFu

My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA

The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un

📺 Watch my most popular videos:📺

Neil Turok https://www.youtube.com/watch?v=Dt5cFLN65fI

Frank Wilczek https://youtu.be/3z8RqKMQHe0?sub_confirmation=1

Eric Weinstein vs. Stephen Wolfram https://www.youtube.com/watch?v=OI0AZ4Y4Ip4?sub_confirmation=1

Sir Roger Penrose: https://youtu.be/AMuqyAvX7Wo

Sabine Hossenfelder: https://youtu.be/g00ilS6tBvs

Avi Loeb: https://youtu.be/N9lUceHsLRw

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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating #michaellevin

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Did We Detect Dark Matter… or Fool Ourselves? Oct 21, 2025

Show notes

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What if 85% of the universe is invisible—and the one experiment claiming to have found it is wrong?

For nearly three decades, Italian physicists have claimed their DAMA/LIBRA experiment detected the elusive particles that make up dark matter—the mysterious substance holding galaxies together. Yet no one else has ever confirmed it.

Join Brian Keating, UCSD cosmologist and host of The INTO THE IMPOSSIBLE Podcast, as he visits Kaixuan Ni and his team—scientists building the world’s most sensitive detectors deep underground—to uncover:

• ⚛️ How detectors using liquid xenon can “fingerprint” single atomic collisions.

• 💡 Why dark matter’s “heartbeat” signal divided physicists for 30 years.

• ☢️ How dark-matter detectors are now being repurposed to detect nuclear weapons and monitor reactors remotely.

• 🌞 The shocking discovery of solar neutrinos and ultra-rare nuclear decays—phenomena rarer than the age of the universe itself.

This is the invisible architecture of reality—where cosmology meets particle physics, and theory meets obsession.

📍 Filmed at UC San Diego’s Mayer Hall and Harold Urey Hall — home to experiments that may finally prove what 85% of the cosmos is made of.

👇 Watch till the end to see how a failed dark-matter search could save the world from nuclear war.

Key Takeaways:

00:00 "Dark Matter Detection Debate"

04:51 "Physics, Peace, and Deuterium"

08:20 "Annual Modulation from Dark Matter"

10:05 Particle Physics' Atomic Fingerprinting Revolution

16:03 "Data Processing for Dark Matter"

18:56 "Boron-8 Neutrinos Observed"

22:43 "Exploring Electron Recall Signal Excess"

24:22 "Xenon Experiment Resolves Signal Mystery"

30:11 S1, S2 Signal Discrimination

33:11 "Radon Control for Clean Detection"

34:26 "From Cosmic Mysteries to Peace"

38:10 Dark Matter: Undetected Mystery

🎥 Directed & Narrated by: Brian Keating

🔬 Featuring: Prof. Kaixuan Ni, Prof. Liang Yang, Zihao Shi (Columbia)

📍 Location: UC San Diego

🎙️ From The Professor Keating Experiments series

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Will this NEW Scientific Breakthrough Make Us Immune to Everything? George Church - #524 Oct 17, 2025

Show notes

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Today's guest made bacteria immune to every virus that exists. This breakthrough could revolutionize medicine by creating virus proof cell therapies and potentially extending this protection to human cells. Also demonstrating that we can fundamentally rewrite the language of life itself, something that was previously thought impossible.

George Church is a Harvard Medical School genetics professor and pioneer of synthetic biology. He's an entrepreneur who's found in multiple biotech companies and is known for pushing the boundaries between science fiction and reality. His team just did something that sounds like pure science fiction.

They made living cells completely immune to every virus on Earth. That resistant immune, every single virus that tries to infect your cells just fails. The viruses can't evolve around it. Here's the wild part. They didn't add anything new. They just removed a few letter from the genetic alphabet. But George isn't stopping there. He wants to do this to human cells. He's talking about engineering astronauts for Mars missions, bringing back wooly mammoths, and maybe even, just maybe, making humans virus proof to the implications are staggering.

The ethics are murky. And the timeline. Well, if church's track record tells us anything is happening far faster than we think.

KEY TAKEAWAYS

00:00:00 – Church’s team made cells virus-proof, a major medical breakthrough

00:02:34 – Radiation resistance may come from DNA repair linked to desiccation

00:04:43 – A few genes can boost bacteria’s radiation resistance

00:07:16 – Panspermia is unlikely due to harsh space conditions

00:10:50 – Space travel may need biological, not just physical, changes

Regenesis

00:18:19 – Height involves many genes, but single ones can have big effects

00:20:57 – Once sci-fi, genome sequencing and pig organs are now real

00:23:20 – Church and Venter are more collaborators than rivals

00:27:17 – Rewriting genes can create virus-proof organisms

00:35:36 – DNA can store data, but reading/writing is slow

Gattaca

Jurassic Park

00:44:03 – Gene therapies can be affordable for all

00:46:44 – Stem cells can create any body cell for therapy

00:49:15 – “Mirror humans” are possible but avoided ethically

00:53:59 – Genomic privacy isn’t an issue since we shed DNA constantly

00:56:09 – Gene editing helps endangered species adapt, not revive extinct ones

01:00:30 – Virus-proof humans are possible, but tough to deliver to all cells

01:02:59 – Gene therapies could reverse aging at the cellular level

01:04:18 – Church avoids saying “impossible,” but admits to timeline optimism

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Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join

Get a copy of my books:

Think Like a Nobel Prize Winner, with life changing interviews with 9 Nobel Prizewinners: https://a.co/d/03ezQFu

My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA

The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un

Follow me to ask questions of my guests:

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Does Avi Loeb Have PROOF of Alien Technology? Avi Loeb - #523 Oct 12, 2025

Show notes

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—

Once again, I had the pleasure of speaking to one of the most famous and perhaps the most controversial astrophysicists in the world – Avi Loeb!

For those of you who don't know him, Avi is a professor of science at Harvard University, theoretical physicist, astrophysicist, and cosmologist. He is also a bestselling author and a dear friend of mine.

By the time you see this, Avi will have published his new book, Interstellar: The Search for Extraterrestrial Life and Our Future in the Stars. In it, he explains why we need to become an interstellar species to ensure our survival and lays out a plan for how we can settle among the stars.

As usual, we take some time to judge a book by its cover and discuss what went into the making of this book. We also dig into the recent Galileo Project expedition to the Pacific Ocean to retrieve spherules of the first recognized interstellar meteor, IM1, which was led by Avi, and discuss whether they found evidence of alien life.

Judging a book by its cover: Interstellar (00:44)

On extraordinary evidence (08:13)

Does Avi have proof of alien life?! (13:55)

On David Grusch and government obligations (28:01)

Internet hate, constructive criticism, and the scientific method (42:01)

More on Interstellar and what it means to become an interstellar species (1:10:56)

Elon Musk’s plan to make humankind interplanetary (1:15:12)

On space archaeology (1:21:08)

Rapid fire audience questions (1:39:20)

Outro (1:50:57)

—

Additional resources:

📚 Interstellar by Avi Loeb: https://a.co/d/gN18ylO

📺 Watch my most popular videos:

• Neil Turok Believes Physics Is In Crisis (...

• Nobel Prizewinner Frank Wilczek: Beautiful...

• Stephen Wolfram vs. Eric Weinstein: Mathem...

• Nobel Prize in Physics, Black Holes and Wo...

• “I Don’t Care About Your Theory of Everyth...

• UFOs & UAPs: The Situation Has Changed! Av...

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Brian Keating on Humility, Chutzpah, and the Arrow of Time | The James Altucher Show Oct 10, 2025

Show notes

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Brian Keating and James Altucher have an unfiltered talk on humility, arrogance, and the strange mix of traits needed to achieve great things. From the wisdom of the Talmud to the Dunning–Kruger effect, they explore why even Nobel Prize winners wrestle with imposter syndrome.

James shares how writing books requires a mix of blind confidence and humility, while Brian connects scientific resilience to obsession, quests, and flow states. The two also talk candidly about the challenges of writing and publishing science books in today’s world—and Brian previews his bold new project exploring Jim Simons, “Chern–Simons Theory,” and the very arrow of time itself.

What You’ll Learn

Why success requires balancing humility with courage—and sometimes arrogance with ignorance
How Nobel Prize winners secretly struggle with imposter syndrome
Why writing books demands both blind confidence and ruthless editing
The difference between obsession and quest when pursuing success
What “Chern–Simons Theory” reveals about time, space, and the structure of the universe

Timestamped Chapters

00:00 Humility and Chutzpah in Science

06:35 "Feel Good Productivity Insights"

08:08 Considering Career Change for Fulfillment

10:36 "The Genius of Science"

13:54 Topology Links Time and Dimensions

—

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Chris Hadfield’s Final Orbit! The Moon Landing Hoax, UAPs, China & the New Space Race - #522 Oct 09, 2025

Show notes

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Astronaut and bestselling author Chris Hadfield joins me to discuss his new Cold War thriller Final Orbit and the real history behind it—UAPs, Operation Paperclip, and the exiled genius who built China’s rocket program. Along the way, we debate the moon landing hoax, the cost of the ISS, and why humans—not robots—must carry our story into the stars.

Key Takeaways:

00:00 Intro

03:06 The Cold War and space exploration
05:40 Conspiracy theories, UAPs, and whistleblowers
10:38 Checklists as a survival tool
16:06 Moon landing denial
21:26 Judging a book by its cover
26:38 Apollo-Soyuz collaboration
30:59 The legacy of Wernehr von Braun
34:20 McCarthyism and the future of space exploration
38:24 Chinese space program and rivalry
44:19 Is it reckless to send humans to space?
48:54 Outro

Additional resources:

➡️ Follow Chris Hadfield:

✖️ Twitter: https://x.com/cmdr_hadfield?lang=en
📚 Explore Chris Hadfield’s books: https://chrishadfield.ca/books/

➡️ My new book:

📖 Into the Impossible Volume 2: Focus Like a Nobel Prize Winner: Lessons from Laureates to Concentrate Your Creativity and Ignite Your Career: ⁠https://a.co/d/hi50U9U⁠

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From Pipe Bombs to Viagra: Nobel Prize Winner’s Secrets Revealed - Lou Ignarro - #521 Oct 06, 2025

Show notes

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Lou Ignarro went from building pipe bombs as a curious teen to winning the Nobel Prize for discovering how a gas—nitric oxide—regulates blood flow, fuels Viagra, and revolutionized cardiovascular medicine. In this explosive conversation, we trace how one molecule transformed sex, science, and the story of human health.

Key Takeaways:

00:00 Intro

00:55 The molecule that saves and kills

04:00 The invention of the X-ray

05:44 Nitroglycerin: explosive or life-saving drug?

11:07 Fine-tuning and Lou’s religious beliefs

14:38 Judging a book by its cover

16:56 The importance of curiosity

20:00 Thoughts on the Nobel Prize

24:58 What does Viagra do and how does it work?

32:10 The importance of collaboration in scientific research

35:15 Achieving the breakthrough discovery

41:02 What happens if a woman takes viagra?

42:55 Other applications of nitric oxide

47:57 Lou’s heart-healthy diet

52:41 Outro

Additional resources:

➡️ Follow Lou Ignarro:

✖️ Twitter: https://x.com/drignarro

📚 Dr. NO by Lou Ignarro: https://a.co/d/gSarIKX

➡️ My new book:

📖 Into the Impossible Volume 2: Focus Like a Nobel Prize Winner: Lessons from Laureates to Concentrate Your Creativity and Ignite Your Career: https://a.co/d/hi50U9U

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EXCLUSIVE: Avi Loeb Reveals: What HiRISE Just Saw on Mars! #520 Oct 04, 2025

Show notes

Harvard astrophysicist Avi Loeb joins Brian Keating to discuss a groundbreaking observation: the HiRISE camera on NASA’s Mars Reconnaissance Orbiter has imaged 3I/ATLAS, a rare interstellar visitor, from the vantage point of Mars.

In this episode, we explore:

• What HiRISE detected and why it matters for planetary science.

• How interstellar objects like ʻOumuamua and 3I/ATLAS challenge our theories.

• Why Mars may become an ideal outpost for detecting future interstellar visitors.

• The implications for astrobiology, planetary defense, and our search for extraterrestrial technology.

✨ Just as the 1977 “Wow! Signal” jolted radio astronomers with a one-time unexplained burst, 3I/ATLAS may be its optical cousin—an anomalous, fleeting, but potentially transformative messenger. Loeb even calculated that 3I/ATLAS’s trajectory passed within about one degree of the Wow! Signal’s sky position, making the connection more than metaphorical. Ignoring such rare alignments risks repeating history: anomalies slip through our fingers while orthodoxy insists nothing unusual happened. The Wow! Signal warned us of the danger of complacency; 3I/ATLAS reminds us that cosmic surprises often lurk at the margins of expectation, carrying lessons we may miss if we force every mystery into old categories.

🚀 EXCLUSIVE: Avi Loeb Reveals What HiRISE Just Saw on Mars! 🌌

Harvard astrophysicist Avi Loeb joins me to discuss the latest revelations about interstellar object 3I/ATLAS as it makes its closest approach to Mars. From HiRISE images to unusual chemistry, polarization anomalies, and even a potential link to the Wow! Signal, this conversation explores whether 3I/ATLAS is a natural comet—or a possible technological artifact. Along the way, we cover censorship from Galileo to today’s UAP debates, the “Sputnik moment” of interstellar objects, and what a global response might look like.

⏱️ Timestamps

0:00 – Introduction & why this day is special

1:29 – 3I/ATLAS closest approach to Mars: HiRISE imaging

2:50 – Mass, size, and what it means for its trajectory

5:06 – Global spacecraft observing 3I/ATLAS (NASA, ESA, UAE, China)

7:21 – Explaining the anomalies: jets, chemical makeup, negative polarization

13:06 – Alignment with the plane of planets (0.2% likelihood)

14:31 – Coincidence with the Wow! Signal and radio SETI opportunities

18:52 – White paper to the UN: global response to interstellar visitors

24:21 – Perseverance rover possible detection of ATLAS

29:47 – Nickel–iron anomaly and unusual chemistry

36:44 – Science inefficiency & missed discoveries (Hot Jupiters analogy)

43:29 – Why critics are wrong about “just a comet”

55:04 – Galileo, Pinker, and common knowledge parallels to UAP debates

1:01:20 – Peer review, censorship, and suppression in modern science

1:03:59 – Anti-science, conspiracy theories, and science communication

1:11:55 – Risk vs. safety in research; why scientists avoid anomalies

1:23:28 – China, Mars samples, and the race for extraterrestrial life

1:37:32 – JWST chemistry results: carbon dioxide vs water

1:41:42 – Should we send signals to 3I/ATLAS?

1:44:12 – Wake-up call for humanity & final reflections

️ The INTO THE IMPOSSIBLE Podcast has featured 22 Nobel Prize winners, Fields Medalist Terence Tao, and legendary mathematician Jim Simons. Subscribe to join the conversation at the frontiers of science, math, and technology.

👉 What do YOU think HiRISE really saw? Could 3I/ATLAS change how we understand our place in the cosmos? Drop your thoughts in the comments below!

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Is AI Our PARTNER or Our ENEMY? Google CTO Blaise Agüera y Arcas - #519 Sep 30, 2025

Show notes

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Is AI our partner in evolution, or is it a harbinger of our downfall?

In this episode of Into the Impossible, I sit down with two brilliant minds to explore the current and future relationship between artificial intelligence, human evolution, and creativity. Blaise Agüera y Arcas, a leading AI researcher, and Benjamin Bratton, philosopher and theorist, bring their unique insights to this conversation. Together, we discuss how AI is not here to replace us but to reshape what it means to be human, through symbiosis rather than competition.

We explore the concept of the hardware lottery, the role of randomness and creativity in both human brains and machines, and how AI can help us rethink the concept of evolution itself. From quantum computing to AI’s future in medicine and education, this conversation explores the big questions shaping tomorrow’s world.

—

Key Takeaways:

00:00:00 Einstein's happiest thought and the hardware lottery

00:11:13 Co-evolution and human-AI interaction
00:12:44 Is AI training us?
00:15:43 The limitations of AI
00:23:19 Ethical considerations of AI use
00:26:42 The path to a new physics
00:30:32 Blaise’s books explained
00:40:23 It takes a computer to know a computer
00:44:30 The role of improvisation
00:47:19 The role of predictability
00:52:48 Where are we now?
00:57:01 AI, education, and daily use cases
01:02:27 Judging a book by its cover
01:11:29 Outro

—

Additional resources:

📚 Who Are We Now? by Blaise Aguera y Arcas: https://a.co/d/aG81gqL

➡️ Follow me on your fav platforms:

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—

Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known.

Make sure to follow/subscribe so you never miss an episode!

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The Scientists: Lord Kelvin’s Dangerous Idea (Absolute Zero) Sep 28, 2025

Show notes

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Dive into the fascinating world of Lord Kelvin, a pivotal figure in the scientific revolution! In this video, we explore his groundbreaking contributions, including the concept of absolute zero and the Kelvin temperature scale.

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Timestamps:

00:00- Introduction to Lord Kelvin
02:15- The significance of absolute zero
05:30- Kelvin's early academic achievements
08:45- The cosmic microwave background explained
12:00- The evolution of physics from natural philosophy
15:30- The enduring legacy of Kelvin's work
17:00- Conclusion and reflections
-

Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join

📚 Get a copy of my books:

Think Like a Nobel Prize Winner, with life changing interviews with 9 Nobel Prizewinners: https://a.co/d/03ezQFu

My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA

The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un

-

Follow me to ask questions of my guests:
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