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In this fascinating study from UCSD, researchers demonstrate for the first time that time-restricted-feeding (TRF), or intermittent fasting, can synchronize neuronal tissue clocks. This results in the Alzheimer's disease mice to have better sleep, improved sleep length, less irritability, better metabolic dynamics, reduced plaque load and improved plaque clearance, and improved abeta42/abeta40 ratio, with memory improvements almost equal to healthy mice. Let's review.
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References (Aug. 25, 2023)
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https://www.sciencedirect.com/science/article/pii/S1550413123002735?via%3Dihub
Overview of Circadian Rhythms - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707128/#:~:text=Light%20represents%20the%20most%20important%20Zeitgeber.&text=A%20standardized%2024%2Dhour%20notation,night%2C%20or%20the%20dark%20phase
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Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses - PubMed
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Zeitgeber times (ZT) when NOR tasks were carried out. ZT 0 corresponds... | Download Scientific Diagram
https://www.researchgate.net/figure/Zeitgeber-times-ZT-when-NOR-tasks-were-carried-out-ZT-0-corresponds-to-the-time-when_fig3_269725496
What's Tau Got to Do With it? - InVivo Biosystems
https://invivobiosystems.com/disease-modeling/whats-tau-got-to-do-with-it/
Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment - PubMed
https://pubmed.ncbi.nlm.nih.gov/17374949/
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The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759380/
High Morning Blood Glucose | ADA
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Case Report: Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PMC
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650620/#:~:text=Amyloid%20pathogenesis%20starts%20with%20altered,and%20interferes%20with%20synaptic%20signaling
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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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