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    Health & Fitness

    Huberman Lab – Scicomm Media

    The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

    Advertise

    Copyright: Copyright © 2021-2022 Scicomm Media LLC

    • Apple Podcasts
    • Google Play
    • Spotify

    Latest Episodes:
    Understand & Improve Memory Using Science-Based Tools | Episode 72 May 16, 2022

    This episode I explain the mechanisms by which different types of memories are established in our brain and how to leverage the amount and timing of key neurochemicals and hormones, such as adrenaline (aka epinephrine) and cortisol, to improve your learning and memory abilities. I describe multiple science-based protocols to do this, including repetition, caffeine, emotional states, deliberate cold exposure, sleep, meditation, and the role of vision, including taking “mental snapshots.” I also describe how exercise and an associated hormone, osteocalcin, can improve cognitive ability and memory formation. I also describe unique aspects and forms of memory such as photographic memory, extreme facial recognition (aka super recognition), and the phenomenon known as déjà vu.

    Thank you to our sponsors

    Eight Sleep: https://www.eightsleep.com/huberman

    Thesis: https://takethesis.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Momentous

    https://www.livemomentous.com/huberman.

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Memory, Improving Memory

    (00:02:45) Eight Sleep, Thesis, InsideTracker

    (00:07:54) Sensory Stimuli, Nervous System & Encoding Memory

    (00:11:12) Context & Memory Formation

    (00:13:46) Tool: Repetition, Improving Learning & Memory

    (00:17:11) Co-Activation and intensity Neuron Activation

    (00:20:50) Different Types of Memory

    (00:25:40) Memory Formation in the Brain, Hippocampus

    (00:28:00) Hippocampus, Role in Memory & Learning, Explicit vs. Implicit Memory

    (00:31:49) Emotion & Memory Enhancement

    (00:36:44) Tool: Emotion Saliency & Improved Memory

    (00:41:42) Conditioned-Placed Avoidance/Preference, Adrenaline

    (00:47:14) Adrenaline & Cortisol

    (00:49:35) Accelerating the Repetition Curve & Adrenaline

    (00:53:03) Tool: Enhancing Learning & Memory - Caffeine, Alpha-GPC & Stimulant Timing

    (01:00:50) Tool: Enhancing Learning & Memory - Sleep, Non-Sleep Deep Rest (NSDR)

    (01:04:48) Tool: Enhancing Learning & Memory - Deliberate Cold Exposure, Adrenaline

    (01:08:42) Timing of Adrenaline Release & Memory Formation

    (01:12:36) Chronically High Adrenaline & Cortisol, Impact on Learning & Memory

    (01:15:12) Adrenaline Linked with Learning: Not a New Principle

    (01:17:25) Amygdala, Adrenaline & Memory Formation, Generalization of Memories

    (01:22:20) Tool: Cardiovascular Exercise & Neurogenesis

    (01:27:00) Cardiovascular Exercise, Osteocalcin & Improved Hippocampal Function

    (01:29:59) Load-Bearing Exercise, Osteocalcin & Cognitive Ability

    (01:34:41) Tool: Timing of Exercise, Learning & Memory Enhancement

    (01:37:29) Photographic Memory

    (01:38:49) “Super Recognizers,” Facial Recognition

    (01:41:46) Tool: Mental Snapshots, Photographs & Memory Enhancement

    (01:49:12) Déjà Vu

    (01:53:24) Tool: Meditation, Daily Timing of Meditation

    (02:02:21) How to Enhance Memory

    (02:05:51) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Understanding & Controlling Aggression | Episode 71 May 09, 2022

    This episode I describe the neural mechanisms that activate and control aggressive states and beahviors and the role of hormones—estrogen and testosterone—in mediating violent and and/or competive aggression. I also describe tools that can be used to modulate the factors that have been shown to ‘prime’ an individual for aggression, including sunlight, estrogen sensitivity, competition within social settings, and overall stress levels, and the hormone cortisol. I discuss how substances such as caffeine and alcohol can impact impulsive behaviors, and how nutrition and supplementation can be used to regulate mood and aggression.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    ROKA: https://www.roka.com -- code: huberman

    Helix Sleep: https://www.helixsleep.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Momentous

    https://www.livemomentous.com/huberman.

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Aggression, Types of Aggression

    (00:03:33) AG1 (Athletic Greens), ROKA, Helix Sleep

    (00:08:29) Neural Circuits for Aggression, “Hydraulic Pressure Model”

    (00:15:50) Brain Regions Controlling Aggression, Ventromedial Hypothalamus (VMH)

    (00:22:14) Psychiatric Disorders & Aggression

    (00:23:36) Stimulation of the VMH, Estrogen Receptors & Aggression

    (00:31:57) Neural Circuits Mediating Physical Acts of Aggression, Biting

    (0:35:56) Testosterone & Competitiveness/Estrogen & Aggression

    (00:43:00) Sunlight, Melatonin & Aggression

    (00:45:46) Cortisol, Serotonin & Aggressive Behaviors

    (00:51:56) Tool: Omega-3 Supplementation & Mood

    (00:54:18) Tool: Sunlight, Sauna & Cortisol Reduction

    (00:55:54) Tool: Ashwagandha & Cortisol Reduction

    (00:57:06) Tool: Seasonality/Sunlight, Genetic Variation in Estrogen Sensitivity

    (01:00:37) Testosterone & Aggression, Competitive Work Environments

    (01:05:07) Testosterone, Amygdala, Challenge & Effort

    (01:09:27) Caffeine, Alcohol & Impulsivity

    (01:13:15) Tool: Caffeinated Alcohol Beverages, Impulsivity & Aggression

    (01:17:18) Tool: ADHD, Acetyl-L Carnitine & Aggressive Behavior

    (01:24:10) Factors Affecting the “Hydraulic Pressure Model” of Aggression

    (01:25:44) Book by Dr. David Anderson, Aggression & Social Relationships

    (01:27:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Episode 70 May 02, 2022

    My guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children’s Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    Thesis: https://takethesis.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Momentous

    https://www.livemomentous.com/huberman.

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure

    (00:03:12) Momentous Supplements

    (00:04:27) The Brain-Body Contract

    (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker

    (00:09:42) Stress Response Pathways, Hormesis

    (00:16:38) Plants, Polyphenols, Sulforaphane

    (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed

    (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response

    (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)

    (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges

    (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2

    (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation

    (00:48:40) EPA Omega-3s & Depression

    (00:52:02) Krill Oil vs. Fish Oil Supplements?

    (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy

    (00:59:24) Tool 4: Food Sources of EPA Omega-3s

    (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing

    (01:10:22) Benefits of Omega-3s

    (01:14:40) Tool 5: Food Sources of DHA Omega-3s

    (01:17:07) Vitamin D & Sun Skin Exposure

    (01:22:18) Role of Vitamin D, Gene Regulation

    (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation

    (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D

    (01:34:23) Vitamin D & Longevity

    (01:36:46) Sun Exposure & Sunscreen

    (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables

    (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate

    (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety

    (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation

    (02:02:30) Tool 11: Cold & Fat ‘Browning’, PGC-1alpha, Metabolism

    (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle

    (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna

    (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood

    (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory

    (02:19:53) Sauna, Vasodilation & Alzheimer’s and Dementia Risk

    (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)

    (02:31:29) Insulin signaling, FOXO3 & Longevity

    (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility

    (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin

    (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals

    (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    The Science & Health Benefits of Deliberate Heat Exposure | Episode 69 Apr 25, 2022

    I describe the mechanisms by which deliberate heat exposure impacts body temperature, metabolism, heart health, hormone production, exercise recovery, cognition, mood, and longevity. I detail specific protocols for deliberate heat exposure, including exposure times, temperature ranges to consider, time of day, and delivery mechanisms (sauna vs. hot bath vs. open air heat, etc.) in order to achieve different specific outcomes, including dramatic growth hormone releases, or reduction in cortisol levels. I also discuss the ability of locally applied heat to heal or otherwise improve various bodily tissues and new data on how local application of heat may induce the conversion of metabolically sluggish white fat to metabolically robust beige fat.

    Thank you to our sponsors

    LMNT: https://drinklmnt.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    ROKA - https://www.roka.com - code "huberman"

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Momentous

    I am pleased to announce that the Huberman Lab Podcast is now partnered with Momentous. Momentous supplements are of the very highest quality; each is third-party tested for purity and accuracy of dosage. To learn more about the Huberman Lab Podcast-Momentous partnership, the supplements I that take, and stay up-to-date with future product announcements, visit: https://www.livemomentous.com/huberman.

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Heat & Health

    (00:03:37) Momentous Supplements

    (00:04:52) The Brain-Body Contract

    (00:05:46) LMNT, InsideTracker, ROKA

    (00:09:31) Body Shell Temperature vs. Body Core Temperature

    (00:13:28) Thermal Regulation, Hyperthermia

    (00:17:36) Heat Removal Circuits, Pre-Optic Hypothalamus (POA)

    (00:26:30) Protocols & Benefits of Deliberate Heat Exposure

    (00:33:37) Tools & Conditions for Deliberate Heat Exposure

    (00:38:47) Deliberate Heat Exposure, Cortisol & Cardiovascular Health

    (00:44:50) Heat Shock Proteins (HSPs), Molecular Mechanisms of Heat Regulation

    (00:47:56) Longevity & Heat Exposure, FOXO3

    (00:52:30) Deliberate Cold & Heat Exposure & Metabolism

    (00:54:48) Deliberate Heat Exposure & Growth Hormone

    (01:04:32) Parameters for Heat & Cold Exposure

    (01:08:26) Circadian Rhythm & Body Temperature, Cold & Heat Exposure

    (01:12:00) Heat Exposure & Growth Hormone

    (01:16:20) Tool: Hydration & Sauna

    (01:17:10) Heat, Endorphins & Dynorphins, Mood

    (01:28:44) Tool: Glabrous Skin To Heat or Cool

    (01:35:33) Local Hyperthermia, Converting White Fat to Beige Fat, Metabolism

    (01:47:00) Hormesis/Mitohormesis & Heat/Cold Exposure

    (01:49:11) Benefits of Heat Exposure

    (01:51:10) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Using Light (Sunlight, Blue Light & Red Light) to Optimize Health | Episode 68 Apr 18, 2022

    I describe the mechanisms by which different wavelengths of light impact the cells, tissues and organs of the human body, and how specifically timed light exposure of specific wavelengths can be used to improve sleep, enhance alertness, modulate hormone levels, and improve mood. I also explain the use of ultraviolet and infrared phototherapies to relieve pain increase testosterone and estrogen levels; improve skin health, appearance and wound healing; and how red light can be used to offset age-related vision loss and provide neuroprotection. Throughout the episode, I describe the mechanisms of light-based therapies and actionable tools that people can use positively impact mental and physical health.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    Thesis: https://takethesis.com/huberman

    LMNT: https://drinklmnt.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Using Light to Improve Health

    (00:04:31) The Brain-Body Contract

    (00:05:17) AG1 (Athletic Greens), Thesis, LMNT

    (00:09:56) Physics of Light, Electromagnetic Energy

    (00:12:23) Wavelengths of Light

    (00:15:38) How Light Penetrates Tissues

    (00:20:13) Light & the Body: Direct & Indirect Signals

    (00:28:35) Light, Seasonality & Melatonin

    (00:33:40) Melatonin: Regulatory & Protective Effects

    (00:38:49) Tools: Optimizing Melatonin Levels

    (00:44:49) Sun (UVB light) Exposure, Mating Behavior, Testosterone & Estrogen

    (00:58:09) Seasonality, Romantic Passion & Testosterone

    (01:02:13) Tool: Skin Sun Exposure & Testosterone

    (01:06:13) Light & Improved Pain Tolerance

    (01:11:55) Protocol: Sun Exposure & Chronic Pain

    (01:12:48) Tools: Sunlight (UVB), Blue-Light Blockers, Seasonal Affective Disorder (SAD)

    (01:19:44) Light & Enhanced Immune Function

    (01:23:30) Tool: Light During Winter Months

    (01:26:18) Light Therapies: Local vs. Systemic Exposure

    (01:28:54) Tool: Improving Mood, Timing of Natural & Artificial Light

    (01:32:44) Light Conditions & Sleep Optimization

    (01:39:00) Infrared Light, Skin & Wound Healing

    (01:46:00) Infrared Light Therapy & Skin, Low-Level Laser (Light) Therapy (LLLT)

    (01:49:20) Infrared Light & Age-Related Vision Loss

    (01:59:36) Tools: Infrared Panels, Morning Exposure

    (02:05:22) Infrared Light at Night, Shift Work

    (02:08:35) Light Flicker Phototherapy & Neuroprotection

    (02:19:07) Phototherapies for Health

    (02:20:50) Zero-Cost Support, YouTube Feedback, Spotify Reviews, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter, Brain-Body Contract

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Dr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality | Episode 67 Apr 11, 2022

    My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider.

    Thank you to our sponsors

    Thesis: https://takethesis.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    ROKA: https://roka.com - use code "huberman"

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization

    (00:03:10) The Brain-Body Contract

    (00:04:10) Thesis, InsideTracker, ROKA

    (00:08:24) Preventative Medicine & Hormone Health

    (00:14:17) The Six Pillars of Hormone Health Optimization

    (00:17:14) Diet for Hormone Health, Blood Testing

    (00:20:21) Exercise for Hormone Health

    (00:21:06) Caloric Restriction, Obesity & Testosterone

    (00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1

    (00:29:08) Sleep Quality & Hormones

    (00:35:03) Testosterone in Women

    (00:38:55) Dihydrotestosterone (DHT), Hair Loss

    (00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine

    (00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto

    (00:52:30) Hair loss, DHT, Creatine Monohydrate

    (00:55:07) Hair Regrowth, Male Pattern Baldness

    (00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM

    (01:04:00) Oral Contraception, Perceived Attractiveness, Fertility

    (01:10:31) Testosterone & Marijuana or Alcohol

    (01:14:27) Sleep Supplement Frequency

    (01:15:34) Testosterone Supplementation & Prostate Cancer

    (01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein

    (01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil

    (01:30:54) Testosterone Replacement Therapy (TRT)

    (01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM

    (01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats

    (01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone

    (01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels

    (01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency

    (01:56:44) Boron, Sex Hormone Binding Globulin (SHBG)

    (01:58:13) Human Chorionic Gonadotropin (hCG), Fertility

    (02:04:18) Prolactin & Dopamine, Pituitary Damage

    (02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P)

    (02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic)

    (02:18:19) Blood Test Frequency

    (02:19:41) Long-Term Relationships & Effects on Hormones

    (02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships

    (02:29:05) Cold & Hot Exposure, Hormones & Fertility

    (02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin

    (02:37:24) Growth Hormone-Releasing Peptides (GHRPs)

    (02:39:38) BPC-157 & Injury, Dosing Frequency

    (02:45:23) Uses for Melanotan

    (02:48:21) Spiritual Health Impact on Mental & Physical Health

    (02:54:18) Caffeine & Hormones

    (02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Brain-Body Contract

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Using Deliberate Cold Exposure for Health and Performance | Episode 66 Apr 04, 2022

    I describe mechanisms by which deliberate cold exposure can enhance mental health, physical health, and performance. I detail specific protocols to safely engage in deliberate cold exposure, including minimal exposure times, time-of-day effects, determining optimal temperatures, recovery, mindset, and movement during cold exposure. I discuss how cold exposure can be used to safely stress the body to improve attention, mood, and cognitive focus and boost metabolism and reduce inflammation. Also, I explain how cold exposure on specific regions of the body (called glabrous skin surfaces) can be leveraged to enhance endurance and weight training and increase work output.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    ROKA: https://roka.com - use code "huberman"

    Helix Sleep: https://helixsleep.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Deliberate Cold Exposure, Health Warning

    (00:04:23) Tool: Moderate Exercise & Cognitive Work

    (00:10:47) The Brain-Body Contract

    (00:11:32) AG1 (Athletic Greens), ROKA, Helix Sleep

    (00:15:37) Circadian Rhythm & Body Temperature

    (00:18:41) Tool: Quickly Decrease Core Body Temperature, Glabrous Skin

    (00:25:26) Mental Effects of Cold Exposure

    (00:29:02) Physical Effects of Cold Exposure

    (00:30:11) How Cold Should the Temperature Be?

    (00:34:53) Cold Showers vs. Cold Water Immersion

    (00:38:27) Protocols for Cold Exposure

    (00:50:57) Optimal Mindset(s) During Cold Exposure

    (00:55:26) Tool: Using Movement During Cold Exposure

    (00:57:51) Optimal Frequency of Cold Exposure

    (01:00:22) Cold Exposure for Dopamine, Mood & Focus

    (01:12:55) Cold Exposure & Metabolism, Brown Fat

    (01:25:55) Tool: Caffeine, Dopamine & Cold Exposure

    (01:29:14) Tools: Increasing Metabolism w/Cold – The Søberg Principle, Shivering

    (01:34:15) Norepinephrine & Fat Cells

    (01:36:22) Cold, Physical Performance, Inflammation

    (01:47:36) Hyperthermia & Glabrous Skin Cooling

    (01:53:27) Tool: Palmar Cooling & Endurance

    (02:03:18) Cold Exposure to Groin, Increasing Testosterone

    (02:07:50) Tool: Optimal Timing for Daily Cold Exposure

    (02:11:16) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Reviews, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter

    Title Card Photo Credit: Mike Blabac

    Disclaimer: The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.


    Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance | Episode 65 Mar 28, 2022

    My guest is Dr. Andy Galpin, Professor of Kinesiology at California State University, Fullerton, and one of the foremost experts in the world on the science and application of methods to increase strength, hypertrophy and endurance performance. We discuss fundamental principles of strength and hypertrophy training and building endurance, the mechanisms underlying them and we review specific protocols to optimize training and recovery. We also discuss hydration, sleep, nutrition, supplements, and mental tools that can be leveraged to accelerate adaptations leading to enhanced strength, muscle growth and/or endurance.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    Thesis: https://takethesis.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Dr. Andy Galpin, Strength & Endurance Training

    (00:03:08) The Brain-Body Contract

    (00:03:55) AG1 (Athletic Greens), Thesis, InsideTracker

    (00:08:20) Adaptations of Exercise, Progressive Overload

    (00:14:40) Modifiable Variables, One-Rep Max, Muscle Soreness

    (00:27:30) Modifiable Variables of Strength Training, Supersets

    (00:43:50) How to Select Training Frequency: Strength vs. Hypertrophy

    (00:58:45) Hypertrophy Training, Repetition Ranges, Blood Flow Restriction

    (01:08:50) Tools: Protocols for Strength Training, the 3 by 5 Concept

    (01:10:48) Mind-Muscle Connection

    (01:16:16) Mental Awareness

    (01:27:57) Breathing Tools for Resistance Training & Post-Training

    (01:37:25) Endurance Training & Combining with Strength

    (01:51:20) Tools: Protocols for Endurance Training

    (02:08:15) Muscular Endurance, Fast vs. Slow Twitch Muscle

    (02:16:35) Hydration & the Galpin Equation, Sodium, Fasting

    (02:35:57) Cold Exposure & Training

    (02:43:15) Heat Exposure & Training

    (02:53:47) Recovery

    (03:04:02) Tool: Sodium Bicarbonate

    (03:17:26) Tool: Creatine Monohydrate

    (03:20:08) Absolute Rest

    (03:29:08) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Controlling Sugar Cravings & Metabolism with Science-Based Tools | Episode 64 Mar 21, 2022

    I explain how to blunt sugar cravings through fundamental knowledge of how sugar is sensed, metabolized, and utilized within the body. I explain how sugar is processed through the digestive tract and nervous system and how both the taste and nutritive components of sugar can lead to specific appetite changes and cravings. I discuss the connection between sugar, dopamine, and cravings and outline many tools to curb sugar cravings, specifically craving highly processed refined sugars.

    Thank you to our sponsors

    Thesis: https://takethesis.com/huberman

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Sugar & Physiology

    (00:02:25) The Brain-Body Contract

    (00:03:13) Thesis, AG1 (Athletic Greens), InsideTracker

    (00:07:40) Sugar & the Brain

    (00:10:06) Appetite & Hormones: Ghrelin & Insulin

    (00:14:17) Glucose & Brain Function

    (00:24:19) Glucose & Physical Activity

    (00:26:16) Fructose vs. Glucose

    (00:32:41) When to Eat High-Sugar Foods?

    (00:35:01) Sugar’s Taste vs. Nutritive Pathways, Sugar Cravings

    (00:41:46) Tool: Sugar & the Dopamine, Pleasure – Pain Dichotomy

    (00:48:43) Subconscious Sugar Circuits, Hidden Sugars in Food

    (00:58:03) Glucose Metabolism in the Brain

    (01:03:00) Tool: Glycemic Index, Blunting Sugar Cravings

    (01:12:08) Sugary Drinks, Highly Refined Sugars

    (01:14:33) Artificial Sweeteners

    (01:22:36) ADHD, Omega-3s

    (01:30:18) Tools: Reduce Sugar Cravings with EPA Omega-3s & Glutamine

    (01:35:15) Tool: Blunt Sugar Peaks & Craving with Lemon Juice

    (01:43:09) Tool: Reduce Sugar Cravings & Spikes with Cinnamon

    (01:45:10) Berberine, Sustained Low Blood Glucose Levels

    (01:51:24) Tool: Sleep & Sugar Cravings

    (01:56:33) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Instagram, Twitter, Thorne, Neural Network Newsletter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Using Salt to Optimize Mental & Physical Performance | Episode 63 Mar 14, 2022

    I discuss the role of salt (sodium) in the nervous system and the key role that it plays in mental performance, physical performance and health. I explain how the brain senses salt levels in our body and how that relates to our feelings of thirst. I cover the physiology of the renal system and the hormones that control sodium and water balance in our body. I also explore how salt interacts with stress and our immune systems and its crucial role in neuron function. Additionally, I examine research findings suggesting that some individuals might benefit from increased intake of sodium and other electrolytes (magnesium and potassium) to enhance mental performance, lessen anxiety, and offset dizziness. Yet, other people may need less sodium. I discuss how you can determine your optimal sodium intake and why sodium intake levels need to be uniquely tailored to an individual’s lifestyle. Finally, I explain how salt creates ‘hidden’ sugars in many processed foods and the problems that can create. Throughout the episode, I explain peer-reviewed findings outlining salt’s essential role in overall health and describe general recommendations and tools anyone can use to find their optimal salt balance and thereby enhance their brain and body’s performance.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    LMNT: https://drinklmnt.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Role of Salt

    (00:02:18) The Brain-Body Contract

    (00:02:57) Neuropod Cells, Artificial Sweeteners & ‘Hidden’ Cravings

    (00:10:57) AG1 (Athletic Greens), LMNT, InsideTracker

    (00:15:06) Salt Regulation

    (00:17:13) How the Brain Senses Salt

    (00:24:15) Salt & Thirst

    (00:29:27) Blood Pressure & Thirst

    (00:33:47) Kidneys & Urine Regulation

    (00:39:08) Vasopressin: Roles in Libido & Urination

    (00:45:46) How Much Salt Do You Need?

    (00:56:45) Should You Increase Your Salt Intake?

    (01:02:19) Tools: Determining Your Individual Salt Intake

    (01:14:02) Iodine, Sea Salt

    (01:17:13) Salt: Roles in Stress & Anxiety

    (01:24:20) Other Electrolytes: Magnesium & Potassium

    (01:27:57) Tools: Effects of Low-carbohydrate Diets & Caffeine

    (01:32:28) General Recommendations for Salt Intake

    (01:36:34) Perception of Salt & Sugar Taste, Processed Foods

    (01:47:13) Role of Sodium in Neuronal Function, Action Potentials

    (01:53:13) Dehydration

    (01:55:36) What Salt Intake is Best for You?

    (02:00:58) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Dr. Justin Sonnenburg: How to Build, Maintain & Repair Gut Health | Episode 62 Mar 07, 2022

    My guest this episode is Dr. Justin Sonnenburg, Professor of Microbiology & Immunology at Stanford University. Dr. Sonnenburg’s research focuses on how microbes in our gut impact our mental and physical health and how diet and your environment shape your gut microbiome. We discuss the architecture of the gut microbiome and microbiota variability in different regions of the gastrointestinal (GI) tract and how these can change in response to diet, environment or genetics. We explore the early establishment of your microbiome and how your mode of delivery into the world (C-section or not) shapes your gut. We also discuss lifestyle factors that can alter your microbiome and the integral role the gut microbiome plays in communicating to other organs, including your brain. Dr. Sonnenburg details his recent clinical study, which found that diets rich in fermented foods (but not fiber) increase microbiota diversity and reduce signals of inflammation. Additionally, we examine how foods typical in Western Diets (e.g., high fat, low fiber, processed foods) can negatively impact the gut microbiome. Throughout the episode, we discuss actionable tools from peer-reviewed clinical findings that anyone can implement, regardless of budget, in order to optimize their gut microbiome and health.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    ROKA: https://roka.com - code "huberman"

    Helix Sleep: https://helixsleep.com/huberman

    See Andrew Huberman Live: The Brain Body Contract

    Tuesday, May 17th: Seattle, WA

    Wednesday, May 18th: Portland, OR

    https://hubermanlab.com/tour - code: ‘huberman’

    Pre-sale tickets go on sale on Tuesday, March 8th at 10 AM PT

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    For the full show notes, visit hubermanlab.com.

    Timestamps

    (00:00:00) Dr. Justin Sonnenburg, Gut Microbiome

    (00:02:55) The Brain Body Contract

    (00:04:16) AG1 (Athletic Greens), ROKA, Helix Sleep

    (00:08:30) What is the Gut Microbiome?

    (00:12:49) Gastrointestinal (GI) Tract & Microbiota Variability

    (00:16:00) Breast Feeding, C-Sections & Pets

    (00:21:56) The Human Microbiome Project at Stanford

    (00:26:30) Traditional vs. Industrialized Populations

    (00:28:58) Resilience of the Microbiome

    (00:35:10) Regional Differences Along Your GI Tract

    (00:42:04) Fasting, Cleanses & Gut Health

    (00:51:19) Dietary Differences

    (01:01:24) Simple vs. Complex Carbohydrates, Processed Foods

    (01:07:03) Artificial & Plant-based Sweeteners

    (01:12:44) Cleanses: Useful? Harmful?

    (01:14:50) Your Microbiome & Your Immune System

    (01:20:17) Dietary Fiber & Fermented Foods

    (01:32:13) High-Fiber vs. High-Fermented Diet; Inflammation

    (01:41:33) Ripple Effects of a Healthy Diet

    (01:45:00) Does a High-Fiber Diet Make Inflammation Worse?

    (01:47:22) Over Sterilized Environments

    (01:50:15) The Gut Microbiome’s Effect on Physiology

    (01:56:45) Gut-Brain Connection

    (01:59:30) Probiotics: Benefits & Risks

    (02:04:20) Prebiotics: Essential?

    (02:07:00) Tools for Enhancing Your Gut Microbiota

    (02:11:12) Dr. Sonnenburg’s Research, Zero-Cost Support, YouTube, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    How to Enhance Your Gut Microbiome for Brain & Overall Health | Episode 61 Feb 28, 2022

    In this episode, I discuss the profound effect the gut has on the nervous system. I cover the structure and function of the gut-brain axis and the role of the gut microbiome in the brain and overall health. I describe how the gut controls hunger or satiety by affecting neurons in our brain. I also contrast the many pathways by which the gut influences the brain: direct vs. indirect pathways, chemical vs. mechanical, and fast vs. slow signaling. Additionally, I discuss what defines a healthy microbiome and how your lifestyle impacts the gut microbiome, including the effects of stress, fasting, antibiotics, pets, environment, prebiotics and probiotics. I address how different foods shape the gut microbiome, in particular, the emerging data that fermented foods can increase the diversity of healthy gut microbiota. Throughout the episode, I explain peer-reviewed and textbook findings that reveal the critical role of the gut microbiome in supporting mental and physical health and I outline simple tools that anyone can use in order to enhance their gut microbiome health.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    LMNT: https://drinklmnt.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    Social & Website

    • YouTube
    • Instagram
    • Twitter
    • Facebook
    • Website
    • Newsletter

    Article Links

    • "The Emerging Biology of Gut-Brain Sensory Transduction"
    • "Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder"
    • "Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study"
    • "Emotional well-being and gut microbiome profiles by enterotype"
    • "Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis"
    • "Gut-microbiota-targeted diets modulate human immune status"
    • "The preference for sugar over sweetener depends on a gut sensor cell"

    Book Links

    • "The 4-Hour Chef: The Simple Path to Cooking Like a Pro, Learning Anything and Living the Good Life"

    Timestamps

    (00:00:00) Gut Microbiome

    (00:03:02) AG1 (Athletic Greens), LMNT, InsideTracker

    (00:06:55) Your Gut-Brain Axis

    (00:09:44) Gut-Brain Anatomy

    (00:15:32) Microbiota vs. Gut Microbiome

    (00:20:01) Roles of Gut Microbiome

    (00:23:03) Neuropod Cells: (Subconscious) Tasting with Your Stomach

    (00:34:13) Ghrelin: Slow Modulation of Your Brain in Hunger

    (00:38:02) Glucagon Like Peptide 1; GLP-1

    (00:42:22) Tools: ‘Free Will’ & Food Cravings

    (00:44:46) Mechanical Cues from Gut to Brain

    (00:49:05) Dopamines, Vomiting

    (00:52:06) Indirect Signals from Gut Microbiota

    (00:59:30) Gut Microbiome “Critical Periods”

    (01:03:08) How Gut Health Controls Overall Health

    (01:12:25) What is a Healthy Gut Microbiome?

    (01:15:00) Tools: Enhance Your Gut Microbiome

    (01:23:49) Foods to Enhance Microbiota Diversity; Fermented Foods

    (01:37:07) High-Fiber Diets & Inflammation

    (01:40:58) Artificial & Non-Caloric Sweeteners

    (01:44:27) Structure & Function of Gut-Brain Axis

    (01:49:47) Zero-Cost Support, YouTube, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Dr. David Spiegel: Using Hypnosis to Enhance Mental & Physical Health & Performance | Episode 60 Feb 21, 2022

    My guest is Dr. David Spiegel MD, Associate Chair of Psychiatry & Behavioral Sciences, Director of the Center on Stress and Health and Director of the Center for Integrative Medicine at Stanford University School of Medicine. Dr. Spiegel has more than 40 years of clinical and research experience with hypnosis, stress physiology, and psychotherapy. In this episode, we examine the role of clinical hypnosis for the treatment of trauma, chronic pain, anxiety and more. Dr. Spiegel explains how to determine your level of ‘hypnotizability’ and provides case studies of incredible successes with hypnosis to treat a variety of ailments. We also discuss how breathing, vision and directed mental focus can modulate internal states and enhance performance. Additionally, we discuss how the adoption of self-hypnosis techniques can reduce stress and enhance sleep in anyone. Dr. Spiegel teaches us how hypnosis works at the neural circuit level to enhance cognitive flexibility. Throughout the episode, Dr. Spiegel summarizes key clinical trials and peer-reviewed findings and resources to work with a trained clinical professional or to do guided self-hypnosis.

    Thank you to our sponsors

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    Thesis: https://takethesis.com/huberman

    ROKA - https://roka.com - code "huberman"

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    Huberman Lab Social & Website

    • YouTube
    • Instagram
    • Twitter
    • Facebook
    • Website
    • Newsletter

    Dr. David Spiegel Links

    • Stanford Center for Stress and Health
    • Support Dr. Spiegel’s Research at Stanford (tax-deductible)
    • Dr. Spiegel’s Published Work
    • Email: david@reveri.com

    Article Links

    • Posthypnotic Amnesia in Hypnotizability Assessment: Validation of a New Scoring System for the Hypnotic Induction Profile
    • Post-traumatic stress disorder and cancer
    • Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability
    • Hypnosis reduces distress and duration of an invasive medical procedure for children

    Other Links

    • Society for Clinical and Experimental Hypnosis
    • American Society for Clinical Hypnosis
    • Watch Andrew’s Hypnosis Session with Dr. Spiegel
    • Reveri website
    • Reveri app (iOS)
    • Join the Waitlist for Reveri for Android

    Timestamps

    (00:00:00) Dr. David Spiegel MD, Hypnosis

    (00:04:16) AG1 (Athletic Greens), Thesis, ROKA

    (00:09:09) Clinical Hypnosis

    (00:16:45) Stage Hypnosis

    (00:20:25) Neurobiology of Hypnosis

    (00:26:04) ADHD

    (00:28:22) Hypnosis for Stress & Sleep

    (00:32:12) Hypnosis to Strengthen Neural Connections

    (00:37:19) Restructuring Trauma Narratives

    (00:45:14) Ketamine Therapy

    (00:50:07) Self-directed Hypnosis, Reveri

    (00:56:53) Eliminating Obsessive Thoughts, Superstitions

    (01:01:50) ‘Hypnotizability’, the Spiegel Eye-roll Test

    (01:15:36) EMDR (Eye Movement Desensitization Reprocessing)

    (01:21:43) Confronting Stress & Trauma

    (01:27:56) The Mind-Body Connection

    (01:31:35) Dealing with Grief

    (01:35:45) Hypnosis in Children & Groups

    (01:40:06) Drug Therapies & Hypnosis

    (01:42:39) Breathing Patterns, Peak Performance

    (01:50:00) Zero-Cost Support, YouTube, Spotify & Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    The Science of Love, Desire and Attachment | Episode 59 Feb 14, 2022

    In this episode, I discuss the psychology and biology of desire, love and attachment. I explain how childhood attachment types are thought to inform adult attachment styles to romantic partners, and I describe some of the major theories of human mate selection, relationships and infidelity. Additionally, I explore the neurobiology and proposed subconscious processing underlying desire, love and attachment, including the roles of empathy and “positive delusion." I outline how self-awareness can shift one’s relationship attachment style towards securely bonded partnerships. Finally, I describe specific tools and supplements that have been researched to increase libido and sex drive. Throughout the episode, I explain the science and key mechanisms underlying romantic love and outline tools for those seeking to find a strong, healthy relationship, or for those wanting to strengthen an existing relationship.

    Thank you to our sponsors

    Thesis: https://takethesis.com/huberman

    AG1 (Athletic Greens): https://athleticgreens.com/huberman

    InsideTracker: https://insidetracker.com/huberman

    Our Patreon page

    https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    https://www.thorne.com/u/huberman

    Social & Website

    YouTube - https://www.youtube.com/andrewhubermanlab

    Instagram - https://www.instagram.com/hubermanlab

    Twitter - https://twitter.com/hubermanlab

    Facebook - https://www.facebook.com/hubermanlab

    Website - https://hubermanlab.com

    Newsletter - https://hubermanlab.com/neural-network

    Article Links

    • Romantic love: an fMRI study of a neural mechanism for mate choice
    • Relationship-specific Encoding of Social Touch in Somatosensory and Insular Cortice
    • Investigating real-life emotions in romantic couples: a mobile EEG study
    • Brain Knows Who Is on the Same Wavelength: Resting-State Connectivity Can Predict Compatibility of a Female–Male Relationship
    • Manipulation of Self-Expansion Alters Responses to Attractive Alternative Partners
    • Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men

    For additional links and resources on Maca, Tongkat Ali and Tribulus, also see links in “Human Effect Matrix” at examine.com.

    Book Links

    • Attached: The New Science of Adult Attachment and How It Can Help You Find and Keep Love
    • Right Brain Psychotherapy
    • The Seven Principles for Making Marriage Work: A Practical Guide from the Country’s Foremost Relationship Expert

    Other Links

    • The Gottman Institute Love Lab: A Research-Based Approach to Relationships
    • New York Times - The 36 Questions that Lead to Love (1/9/2015)

    Timestamps

    (00:00:00) Desire, Love & Attachment

    (00:02:59) Odor, Perceived Attractiveness & Birth Control

    (00:08:04) Thesis, AG1 (Athletic Greens), InsideTracker

    (00:14:13) Romance: Balancing Love & Desire

    (00:19:00) Animal Studies, Vasopressin & Monogamy

    (00:22:06) Strange Situation Task, Childhood Attachment Styles

    (00:32:52) Adult Attachment Styles

    (00:38:50) Secure Attachment

    (00:41:23) Autonomic Arousal: The “See-Saw”

    (00:50:39) Tool: Self-Awareness, Healthy Interdependence

    (00:53:11) Neurobiology of Desire, Love & Attachment

    (00:58:02) Empathy & Mating & the Autonomic Nervous System

    (01:10:02) Positive Delusion, Touch

    (01:15:20) Relationship Stability

    (01:21:22) Selecting Mates, Recognition of Autonomic Tone

    (01:38:28) Neural Mechanisms of Romantic Attachment

    (01:47:43) Autonomic Coordination in Relationships

    (01:56:13) Infidelity & Cheating

    (02:08:56) “Chemistry”, Subconscious Processes

    (02:12:44) Tools: Libido & Sex Drive

    (02:20:20) Maca (Maca root)

    (02:25:58) Tongkat Ali (Longjack)

    (02:28:56) Tribulus terrestris

    (02:33:14) Zero-Cost Support, YouTube, Spotify/Apple Reviews, Sponsors, Patreon, Instagram, Twitter, Thorne

    Title Card Photo Credit: Mike Blabac

    Disclaimer


    Using Play to Rewire & Improve Your Brain | Episode 58 Feb 07, 2022

    In this episode, I discuss the transformative nature of play—how it changes our feelings, thoughts and actions and indeed, how it can rewire our brain to function better in all contexts. I explain the role of play in childhood, as well as adulthood in skill and social development and describe key characteristics of the mind and body during play. Additionally, I explore how play allows the brain to test contingencies in different roles/environments. Throughout, I discuss the underlying neurobiology of play. I also describe how low-stakes play, and tinkering can broaden and shape your future capabilities. Finally, I discuss how our childhood ‘personal play identity’ informs our adult personality. Throughout the episode, I use the science of play to outline recommendations for using play as a means to enhance neuroplasticity and explore novel situations, regardless of age.


    Thank you to our sponsors

    AG1 (Athletic Greens) - https://www.athleticgreens.com/huberman

    ROKA - https://www.roka.com - code "huberman"

    Helix Sleep: http://helixsleep.com/huberman


    Our Patreon page:

    https://www.patreon.com/andrewhuberman


    Supplements from Thorne:

    https://www.thorne.com/u/huberman


    Social & Website

    Instagram - https://www.instagram.com/hubermanlab

    Twitter - https://twitter.com/hubermanlab

    Facebook - https://www.facebook.com/hubermanlab

    Website - https://hubermanlab.com

    Newsletter - https://hubermanlab.com/neural-network


    Article Links

    • Reading on a smartphone affects sigh generation, brain activity, and comprehension
    • In search of the neurobiological substrates for social playfulness in mammalian brains
    • Is chess just a game, or is it a mirror that reflects the child's inner world?
    • A new structural model for the study of adult playfulness: Assessment and exploration of an understudied individual differences variable
    • 5MinuteConsult Journal Club


    Book Links

    • Personal play identity and the fundamental elements in its development process
    • Spark: The Revolutionary New Science of Exercise and the Brain
    • Play It Away: A Workaholic’s Cure for Anxiety


    Timestamps

    (00:00:00) The Power of Play

    (00:02:23) Tool: Reading on Smart Phones, Sighing & Learning

    (00:09:14) AG1 (Athletic Greens), Roka, Helix Sleep

    (00:13:57) Homeostatic Regulation of Play

    (00:23:53) Childhood Play & Mindsets

    (00:29:21) Contingency Testing

    (00:32:17) The (Power of) Playful Mindset

    (00:36:13) Body Postures

    (00:44:03) Rule Testing & Breaking

    (00:48:24) Role Play

    (00:50:39) Neurobiology of Low-stakes Play

    (00:54:22) Expanding Capabilities through Tinkering

    (01:00:03) Play Is THE Portal to Neuroplasticity

    (01:04:44) Adulthood Play

    (01:10:14) Fire Together, Wire Together

    (01:18:03) Trauma & Play Deficits & Recovery

    (01:23:25) Competition & Dynamic Movement

    (01:27:36) Chess, Mental Roles, Novelty

    (01:32:52) Personal Play Identity

    (01:37:24) Play Transforms Your Future Self

    (01:40:55) Recommendations for Play

    (01:44:25) Zero-Cost Support, Spotify/Apple Reviews, YouTube, Sponsors, Patreon, Instagram, Twitter, Thorne


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Optimizing Workspace for Productivity, Focus, & Creativity | Episode 57 Jan 31, 2022

    In this episode, I discuss ways to set up your workspace to optimize productivity, focus and creativity. I discuss how to adjust light, physically arrange your work environment, and leverage body posture to enhance productivity. Additionally, I explore how to shift your work environment for particular types of tasks. Moreover, I review the role of body movement in the workspace. I also discuss sound-based tools that can either enhance or diminish cognitive functioning (the ability to focus on deep work). I describe a particular frequency of binaural beats that studies show can be used to enhance memory and recall. This episode covers quality peer-reviewed findings practical tools anyone can use, regardless of budget, in order to optimize their workspace to achieve heightened levels of productivity, increased alertness and focus, and creativity.


    Thank you to our sponsors

    • LMNT: https://www.drinkLMNT.com/huberman
    • AG1 (Athletic Greens): https://www.athleticgreens.com/huberman
    • Theragun: https://theragun.com/huberman


    Our Patreon

    https://www.patreon.com/andrewhuberman


    Supplements from Thorne

    https://www.thorne.com/u/huberman


    Social & Website

    • Instagram
    • Twitter
    • Facebook
    • Website
    • Newsletter


    Links

    • The Influence of Ceiling Height
    • Heating, Ventilation, & AC Noise During Mental Work
    • Office Noise & Employee Concentration
    • Effects of a Workplace Sit-Stand Desk Intervention on Health & Productivity
    • Effects of Binaural & Monaural Beats on Attention
    • 40-Hz Binaural Beats Enhance Training to Mitigate the Attentional Blink


    Timestamps

    • (00:00:00) Arranging Environment for Focus
    • (00:02:40) LMNT, AG1 (Athletic Greens), Theragun
    • (00:07:55) How to Increase Focus
    • (00:10:02) Lighting Your Work in Phase 1
    • (00:16:00) Lighting Your Work in Phase 2
    • (00:19:45) Lighting Your Work in Phase 3
    • (00:24:17) Where to Look While You Work
    • (00:28:02) Arranging Your Environment
    • (00:31:24) Body Posture
    • (00:34:22) How Long to Do Deep Work
    • (00:36:50) Set the Right Visual Window Size
    • (00:42:15) 45 min / 5 min Rule
    • (00:44:23) The Cathedral Effect: Analytic vs Creative Work
    • (00:55:50) Leveraging Background Noise
    • (01:02:20) Binaural Beats for Work
    • (01:06:38) The Best Binaural Frequency for Work
    • (01:11:17) How Binaural Beats Increase Focus
    • (01:13:56) Minimizing Interruptions
    • (01:20:01) Sit or Stand, or Both?
    • (01:25:18) Movement in the Workspace
    • (01:31:00) Summary & Shifting Work Environments
    • (01:39:36) Zero-Cost Support, Sponsors, Patreon, Instagram, Twitter, Thorne


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Dr. Alia Crum: Science of Mindsets for Health & Performance | Episode 56 Jan 24, 2022

    My guest is Dr. Alia Crum, Associate (tenured) Professor of Psychology at Stanford University and Director of the Stanford Mind & Body Lab. Dr. Crum is a world expert on mindsets and beliefs and how they shape our responses to stress, exercise, and even to the foods we eat. We discuss how our mindset about the nutritional content of food changes whether it is satisfying to us at a physiological (hormonal and metabolic) level. She also tells how mindsets about exercise can dramatically alter the effects of exercise on weight loss, blood pressure, and other health metrics. Dr. Crum teaches us how to think about stress in ways that allow stress to grow us and bring out our best rather than diminish our health and performance. Throughout the episode, Dr. Crum provides descriptions of high-quality peer-reviewed scientific findings that we can all leverage toward better health and performance in our lives.


    Thank you to our sponsors

    • Thesis - https://takethesis.com/huberman
    • ROKA - https://roka.com - code "huberman"
    • InsideTracker - https://insidetracker.com/huberman


    Dr. Alia Crum Links

    • Twitter
    • Stanford Mind & Body Lab
    • Support Dr. Crum’s research at Stanford (tax-deductible)
    • Dr. Crum’s published work


    Our Patreon page: https://www.patreon.com/andrewhuberman


    Supplements from Thorne: https://www.thorne.com/u/huberman


    Huberman Lab Social

    • Instagram
    • Twitter
    • Facebook
    • Website
    • Newsletter


    Links

    • Toolkit for changing stress mindsets
    • Publication on mindsets & side effects
    • Changing patient mindsets about non-life-threatening symptoms during oral immunotherapy
    • Stress, mindsets, and success in Navy SEALs special warfare training
    • Nutritional analysis of foods and beverages depicted in top-grossing US movies, 1994-2018
    • Nutritional Analysis of Foods and Beverages Posted in Instagram Accounts of Highly Followed Celebrities


    Timestamps

    • (00:00:00) Introducing Dr. Alia Crum from Stanford University
    • (00:03:15) Thesis, ROKA, Inside Tracker
    • (00:08:26) What Is a Mindset & What Does It Do?
    • (00:14:45) Mindsets Change Our Biological Responses to Food
    • (00:22:28) Beliefs About Our Food Matter
    • (00:25:57) Placebo vs Beliefs vs Nocebo Effects
    • (00:28:57) Mindset (Dramatically) Impacts the Effects of Exercise
    • (00:33:44) Motivational Messaging & Mindset About Fitness
    • (00:39:30) The Power of a ‘Potency & Indulgence’ Mindset
    • (00:42:03) Mindsets About Sleep, Tracking Sleep
    • (00:45:00) Making Stress Work For (or Against) You
    • (01:01:50) Mindsets Link Our Conscious & Subconscious
    • (01:04:50) 3 Best Ways to Leverage Stress
    • (01:10:40) 4 Things That Shape Mindsets, Influencers & Mindsets
    • (01:19:40) Mindsets About Medicines & Side Effects
    • (01:26:25) How to Teach Mindsets
    • (01:31:47) Dr. Crum’s Research, Clinical & Athletic Backgrounds
    • (01:36:20) The Stanford Mind & Body Lab, Resources for Stress
    • (01:38:30) Synthesis, Participating in Research
    • (01:39:04) Subscribe, Sponsors, Patreon, Instagram, Twitter, Thorne


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    The Science of Setting & Achieving Goals | Episode 55 Jan 17, 2022

    In this episode, I discuss the science of setting, assessing, and pursuing goals. I explain the neural (brain) circuits that underlie goal setting and pursuit. Then I describe nine science-supported tools anyone can apply toward their goals. I explain when and how to use goal visualization, when to use multitasking and how to use specific rewards to improve the likelihood of reaching your goals. I also explain why envisioning failures and their consequences are effective and how to set goals of the appropriate level of challenge. I also explain how the molecule dopamine is used to gauge our progress toward milestones and long-term overarching goals and how to leverage dopamine for goal pursuit. Finally, I explain a unique tool called 'space-time bridging' that can be used to support all aspects of goal setting, assessment, and pursuit. This episode ought to be useful for anyone seeking to improve their performance in work, school, exercise, athletics, or personal development.


    Thank you to our sponsors:

    • LMNT - https://www.drinkLMNT.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman
    • ROKA - https://www.roka.com - code "huberman"

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • The 85% Rule for Optimal Learning
    • Effects of Narrowing Visual Attention on Goal Pursuit Behavior

    Timestamps:

    • (00:00:00) The Neuroscience of Goals
    • (00:01:56) Tool 1: Learn Fast(er) by the 85% Rule
    • (00:06:04) LMNT, Athletic Greens, ROKA
    • (00:13:55) Brain Circuits for Setting & Pursuing Goals
    • (00:21:52) Determining the Value of Goals
    • (00:24:33) Psychology of Goal Setting: Assessing Value, Action Steps
    • (00:30:29) Peripersonal Space vs. Extrapersonal Space
    • (00:35:39) Visually Focusing on a Goal Line Improves Performance
    • (00:43:50) How Vision Improves Performance: Blood Pressure
    • (00:51:55) Tool 2: Use Focal Vision to Initiate Goal Pursuit
    • (00:54:40) Tool 3: Use Aged Self-Images to Self-Motivate
    • (00:59:33) Tool 4: Visualization of Goals is Only Helpful at the Start
    • (01:02:05) Tool 5: Visualizing Failure is the Best Ongoing Motivator
    • (01:07:26) Tool 6: Make Goals Moderately Lofty
    • (01:13:05) Tool 7: Avoid Goal Distraction; Focus on 1-2 Major Goals Per Year
    • (01:15:57) Tool 8: Ensure Specificity of Goals, Weekly Assessment
    • (01:19:57) Dopamine, Motivation & Pleasure in Seeking Goals
    • (01:22:43) Dopamine Reward Prediction Error, Controlling Dopamine
    • (01:34:26) How Dopamine Influences Vision & Vice Versa
    • (01:38:10) Interim Summary of Goal-Pursuit Steps
    • (01:39:50) Tool 9: Space-Time Bridging
    • (01:49:59) Summary
    • (01:51:50) Subscribe, Sponsors, Patreon, Supplements: Thorne, Instagram, Twitter, Newsletter

    Dr. Jack Feldman: Breathing for Mental & Physical Health & Performance | Episode 54 Jan 10, 2022

    This episode my guest is Dr. Jack Feldman, Distinguished Professor of Neurobiology at the University of California, Los Angeles and a pioneering world expert in the science of respiration (breathing). We discuss how and why humans breathe the way we do, the function of the diaphragm and how it serves to increase oxygenation of the brain and body. We discuss how breathing influences mental state, fear, memory, reaction time, and more. And we discuss specific breathing protocols such as box-breathing, cyclic hyperventilation (similar to Wim Hof breathing), nasal versus mouth breathing, unilateral breathing, and how these each affect the brain and body. We discuss physiological sighs, peptides expressed by specific neurons controlling breathing, and magnesium compounds that can improve cognitive ability and how they work. This conversation serves as a sort of "Master Class" on the science of breathing and breathing-related tools for health and performance.

    Thank you to our sponsors:

    • Thesis - https://takethesis.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Our Breath Collective:

    • http://www.ourbreathcollective.com/huberman

    Dr. Jack Feldman Links:

    • UCLA website - https://bioscience.ucla.edu/people/jack-feldman
    • Wikipedia - https://en.wikipedia.org/wiki/Jack_L._Feldman
    • Twitter - https://twitter.com/prebotzinger
    • Instagram - https://www.instagram.com/jacklfeldman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Introducing Dr. Jack Feldman
    • 00:03:05 Sponsors: Thesis, Athletic Greens, Headspace, Our Breath Collective
    • 00:10:35 Why We Breathe
    • 00:14:35 Neural Control of Breathing: “Pre-Botzinger Complex”
    • 00:16:20 Nose vs Mouth Breathing
    • 00:18:18 Skeletal vs. Smooth Muscles: Diaphragm, Intracostals & Airway Muscles
    • 00:20:11 Two Breathing Oscillators: Pre-Botzinger Complex & Parafacial Nucleus
    • 00:26:20 How We Breathe Is Special (Compared to Non-Mammals)
    • 00:33:40 Stomach & Chest Movements During Breathing
    • 00:36:23 Physiological Sighs, Alveoli Re-Filling, Bombesin
    • 00:49:39 If We Don’t Sigh, Our Lung (& General) Health Suffers
    • 01:00:42 Breathing, Brain States & Emotions
    • 01:05:34 Meditating Mice, Eliminating Fear
    • 01:11:00 Brain States, Amygdala, Locked-In Syndrome, Laughing
    • 01:16:25 Facial Expressions
    • 01:19:00 Locus Coeruleus & Alertness
    • 01:29:40 Breath Holds, Apnea, Episodic Hypoxia, Hypercapnia
    • 01:35:22 Stroke, Muscle Strength, TBI
    • 01:38:08 Cyclic Hyperventilation
    • 01:39:50 Hyperbaric Chambers
    • 01:40:41 Nasal Breathing, Memory, Right vs. Left Nostril
    • 01:44:50 Breathing Coordinates Everything: Reaction Time, Fear, etc.
    • 01:57:13 Dr. Feldman’s Breathwork Protocols, Post-Lunch
    • 02:02:05 Deliberately Variable Breathwork: The Feldman Protocol
    • 02:06:29 Magnesium Threonate & Cognition & Memory
    • 02:18:27 Gratitude for Dr. Feldman’s Highly Impactful Work
    • 02:20:53 Zero-Cost Support, Sponsors, Patreon, Instagram, Twitter, Thorne


    Title Card Photo Credit: Mike Blabac

    Disclaimer


    LIFESPAN: The Science Behind Why We Age | Lifespan with Dr. David Sinclair | Episode 1 Jan 05, 2022

    I am honored to share the first episode of the new podcast, Lifespan with Dr. David Sinclair.

    Dr. Sinclair is a professor of genetics at Harvard Medical School. He is also the co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research.

    David is both a friend and a colleague, and I am delighted to have helped him in the creation of this new podcast.

    It will be an 8-episode series that provides a deep dive into the science behind why we age and the newest research on what we can do to slow, stop and even reverse aging.

    While we have Episode 1 of the Lifespan podcast here, please be sure to navigate over to the Lifespan with Dr. David Sinclair podcast channel to subscribe. New episodes will come out every Wednesday for the next 8 weeks. I am certain that you will both enjoy it and learn from it.

    Show notes for this episode can be found on the Lifespan with Dr. David Sinclair podcast channel.

    Title Card Photo Credit: Mike Blabac

    Disclaimer

    Learn more about your ad choices: https://megaphone.fm/adchoices


    The Science of Making & Breaking Habits | Episode 53 Jan 03, 2022

    In this episode, I review the science of habit formation and habit elimination and how the process of neuroplasticity (brain rewiring) underlies these processes.

    I describe two new systems for habit formation. The first system is grounded in the neuroscience of brain states and our ability to perform (and to avoid) certain tasks at different phases of the 24-hour day. The second system focuses on 21-day habit formation and consolidation.

    I also discuss "task bracketing" as an approach to enhancing habit formation and eliminating unwanted habits and the neural circuits that underlie task bracketing in the basal ganglia (a brain region for generating and stopping behaviors). I also review the science of dopamine rewards and how to apply that knowledge to shaping habits.

    The science and tools in this episode ought to be helpful for anyone looking to build better habits and eliminate unwanted habits for school, work, fitness, relationships, creative endeavors, and more—indeed for any person or situation where behavioral changes are needed.

    Thank you to our sponsors:

    • Athletic Greens - http://www.athleticgreens.com/huberman
    • InsideTracker - http://www.insidetracker.com/huberman
    • Helix Sleep - http://www.helixsleep.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Excellent review on science of habits - https://www.annualreviews.org/doi/abs/10.1146/annurev-psych-122414-033417
    • Meta-analysis on habits - https://journals.sagepub.com/doi/full/10.1177/1539449219876877

    Timestamps:

    • 00:00:00 Introducing Habits; New Programs
    • 00:02:30 Athletic Greens, InsideTracker, Helix Sleep
    • 00:06:52 Habits versus Reflexes, Learning, Neuroplasticity
    • 00:08:51 Goal-Based Habits vs. Identity-Based Habits
    • 00:11:40 How Long It (Really) Takes to Form a Habit; Limbic-Friction
    • 00:16:07 Linchpin Habits
    • 00:18:55 Mapping Your Habits; Habit Strength, Context-Dependence
    • 00:22:55 Automaticity
    • 00:24:03 Tool 1: Applying Procedural Memory Visualizations
    • 00:27:48 Hebbian Learning, NMDA receptors
    • 00:31:00 Tool 2: Task Bracketing; Dorsolateral Striatum
    • 00:37:08 States of Mind, Not Scheduling Time Predicts Habit Strength
    • 00:38:16 Tool 3: Phase-Based Habit Plan: Phase 1
    • 00:46:29 Tool 3: Phase-Based Habit Plan: Phase 2
    • 00:55:24 Tool 3: Phase-Based Habit Plan: Phase 3
    • 01:01:34 Habit Flexibility
    • 01:04:57 Should We Reward Ourselves? How? When? When NOT to.
    • 01:10:30 Tool 4: “Dopamine Spotlighting” & Task Bracketing
    • 01:18:22 Tool 5: The 21-Day Habit Installation & Testing System
    • 01:28:26 Breaking Habits: Long-Term (Synaptic) Depression
    • 01:35:49 Notifications Don’t Work
    • 01:37:50 Tool 6: Break Bad Habits with Post-Bad-Habit “Positive Cargo”
    • 01:44:26 Addictions as Habits: https://hubermanlab.com/dr-anna-lembke-understanding-and-treating-addiction/
    • 01:45:28 Conclusion & Synthesis
    • 01:48:27 Zero-Cost Support, Sponsors, Patreon, Supplements, Instagram, Twitter


    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac

    Disclaimer

    Learn more about your ad choices: https://megaphone.fm/adchoices


    Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Episode 52 Dec 27, 2021

    In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.

    In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Magic Spoon - https://www.magicspoon.com/huberman

    Dr. David Sinclair Links:

    • Lifespan Podcast: https://lifespanpodcast.com
    • Twitter: https://twitter.com/davidasinclair
    • Instagram: https://www.instagram.com/davidsinclairphd/
    • YouTube: https://www.youtube.com/davidsinclairpodcast
    • Lifespan (book): https://amzn.to/3mAZQjF
    • Aging Test Waitlist: https://www.doctorsinclair.com
    • Harvard Lab Website: https://sinclair.hms.harvard.edu

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Dr. David Sinclair, Harvard Medical School
    • 00:03:30 ROKA, InsideTracker, Magic Spoon
    • 00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging
    • 00:10:23 What Causes Aging? The Epigenome
    • 00:15:53 Cosmetic Aging
    • 00:17:15 Development Never Stops, Horvath Clock
    • 00:20:12 Puberty Rate as a Determinant of Aging Rate
    • 00:23:00 Fasting, Hunger & Food Choices
    • 00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy
    • 00:34:50 Caffeine, Electrolytes
    • 00:35:56 Blood Glucose & the Sirtuins; mTOR
    • 00:37:55 Amino Acids: Leucine, “Pulsing”
    • 00:44:35 Metformin, Berberine
    • 00:50:29 Resveratrol, Wine
    • 00:53:20 What Breaks a Fast?
    • 00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing
    • 01:09:10 Are Artificial Sweeteners Bad for Us?
    • 01:12:04 Iron Load & Aging
    • 01:15:05 Blood Work Analysis
    • 01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary
    • 01:26:02 Amino Acids, Plants, Antioxidants
    • 01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen
    • 01:40:35 Neuroplasticity & Neural Repair
    • 01:46:19 Ice Baths, Cold Showers, “Metabolic Winter”
    • 01:48:07 Obesity & How It Accelerates Aging, GnRH
    • 01:52:10 Methylation, Methylene Blue, Cigarettes
    • 01:56:17 X-Rays
    • 01:59:00 Public Science Education, Personal Health
    • 02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com
    • 02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    Science of Social Bonding in Family, Friendship & Romantic Love | Episode 51 Dec 20, 2021

    This episode I discuss the science of social bonding- the process by which we form attachments. I explain the neural and hormonal basis for "social homeostasis" (our drive for a given amount of socializing) which reveals why we get lonely, why we seek out connection with others and how power dynamics (hierarchies) shape those connections. I also discuss the neurochemical basis of introversion and extroversion, of trust and how shared experiences that promote similar physiological states in two or more individuals, leads to more rapid bonding. I also discuss how food and oxytocin play key roles in social bonding. This episode covers quality peer-reviewed science and practical tools for anyone seeking to find, build or end relationships.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code "huberman"
    • Athletic Greens - https://www.athleticgreens.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Social Bonding: Child-Parent, Romantic, Friendship, Breakups
    • 00:02:55 ROKA, Athletic Greens, Headspace
    • 00:07:08 Social Bonding as a Biological Process
    • 00:10:03 Social Isolation
    • 00:13:32 Social Homeostasis & Neural Circuits for Social Drive
    • 00:18:55 Brain Areas & (Neuro)Chemistry of Social Drive
    • 00:22:48 What is Social Homeostasis & Dopamine
    • 00:27:00 When We Lack Social Interactions: Short- Versus Long-Term
    • 00:28:10 Introverts & Extroverts
    • 00:31:00 “Good” Versus “Bad” Social Interactions & Hierarchies
    • 00:33:54 Loneliness & Dorsal Raphe Nucleus & Social Hunger
    • 00:37:33 Tools
    • 00:38:05 Socializing & Food Appetite: Crossover Craving
    • 00:42:45 Falling in Love
    • 00:45:05 Tools for Social Bonds: Merging Physiologies; Story
    • 00:53:54 Childhood Attachment Patterns in Adulthood
    • 01:03:45 Attachment Styles: Autonomic Versus Intellectual Attachment
    • 01:06:10 Emotional Empathy & Cognitive Empathy, Arguing
    • 01:09:45 Allan N. Schore & “Right Brain Psychotherapy”
    • 01:10:40 Oxytocin & Trust, In Males Versus Females, Hormonal Glue
    • 01:16:10 Repairing Broken Bonds to Self & Others
    • 01:18:56 Social (Media) Butterflies: Biological Basis
    • 01:24:08 Key Points for Bonding & Understanding Social Bonds
    • 01:27:07 Breaking Up
    • 01:28:36 Synthesis
    • 01:31:17 Zero-Cost Support, Sponsors, Patreon, Thorne, Instagram, Twitter


    Title Card Photo Credit: Mike Blabac

    Disclaimer

    Learn more about your ad choices: https://megaphone.fm/adchoices


    Dr. David Berson: Understanding Your Brain's Logic & Function | Episode 50 Dec 13, 2021

    In this episode, my guest is Dr. David Berson, Professor & Chairman of Neuroscience at Brown University. Dr. Berson discovered the neurons in your eye that set your biological rhythms for sleep, wakefulness, mood and appetite. He is also a world-renowned teacher of basic and advanced neuroscience, having taught thousands of university lectures on this topic. Many of his students have become world-leading neuroscientists and teachers themselves.

    Here Dr. Berson takes us on a structured journey into and around the nervous system, explaining: how we perceive the world and our internal landscape, how we balance, see, and remember. Also, how we learn and perform reflexive and deliberate actions, how we visualize and imagine in our mind, and how the various circuits of the brain coordinate all these incredible feats.

    We discuss practical and real-life examples of neural circuit function across the lifespan. Dr. Berson gives us a masterclass in the nervous system—one that, in just less than two hours, will teach you an entire course's worth about the brain and how yours works.

    Thank you to our sponsors:

    • Athletic Greens - https://athleticgreens.com/huberman
    • InsideTracker - https://insidetracker.com/huberman
    • Magic Spoon - https://magicspoon.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • InsideTracker Interview - https://blog.insidetracker.com/longevity-by-design-andrew-huberman
    • Dr. Berson's Webpage -
    • https://vivo.brown.edu/display/dberson
    • Eyewire - (Contribute to Neuroscience Research from Home/Computer -
    • https://eyewire.org/explore
    • Best Neuroscience Textbook (NOTE this is a TEXTBOOK) - https://amzn.to/3lZWrL4
    • Book - We Know It When We See It by Richard Masland - https://amzn.to/31S60Vp

    Timestamps:

    • 00:00:00 Dr. David Berson
    • 00:02:55 Sponsors: Athletic Greens, InsideTracker, Magic Spoon
    • 00:08:02 How We See
    • 00:10:02 Color Vision
    • 00:13:47 “Strange” Vision
    • 00:16:56 How You Orient In Time
    • 00:25:45 Body Rhythms, Pineal function, Light & Melatonin, Blueblockers
    • 00:34:45 Spending Times Outdoors Improves Eyesight
    • 00:36:20 Sensation, Mood, & Self-Image
    • 00:41:03 Sense of Balance
    • 00:50:43 Why Pigeons Bob Their Heads, Motion Sickness
    • 01:00:03 Popping Ears
    • 01:02:35 Midbrain & Blindsight
    • 01:10:44 Why Tilted Motion Feels Good
    • 01:13:24 Reflexes vs. Deliberate Actions
    • 01:16:35 Basal Ganglia & the “2 Marshmallow Test”
    • 01:24:40 Suppressing Reflexes: Cortex
    • 01:33:33 Neuroplasticity
    • 01:36:27 What is a Connectome?
    • 01:45:20 How to Learn (More About the Brain)
    • 01:49:04 Book Suggestion, my Berson Appreciation
    • 01:50:20 Zero-Cost ways to Support the HLP, Guest Suggestions, Sponsors, Patreon, Thorne

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    Erasing Fears & Traumas Based on the Modern Neuroscience of Fear | Episode 49 Dec 06, 2021

    In this episode, I discuss fear and trauma, including the neural circuits involved in the "threat reflex" and how specific experiences and memories come to activate that system. I also discuss how our body is involved in trauma and fear. First, I describe the logic of fear mechanisms and how "top-down" processing-- meaning connections from the parts of the brain that assign meaning to our feelings, are involved in fear and erasing fears and traumas. Then I discuss what successful fear and trauma treatment must include and consider various treatments for whether they meet that standard, such as EMDR, Cognitive Behavioral Therapy, Ketamine, other drug-assisted therapies, and more. I also review new data on how 5 minutes per day of deliberate, self-imposed stress can erase fear and depression. And I review the role that social connection plays in erasing or maintaining fears by activating specific molecular pathways in the brain and body. Finally, I review supplementation with over-the-counter compounds for their effects on anxiety and fear and when to take them, if at all.

    Thank you to our sponsors:

    • Athletic Greens - https://www.athleticgreens.com/huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Helix Sleep - https://www.helixsleep.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • https://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Introducing Fear, Trauma & Trauma
    • 00:02:15 Athletic Greens, InsideTracker, Helix Sleep
    • 00:06:49 What is Fear?
    • 00:11:45 Autonomic Arousal: “Alertness” vs. “Calmness”
    • 00:13:44 Hypothalamic-Pituitary-Adrenal Axis (HPA axis)
    • 00:17:36 “The Threat Reflex”: Neural Circuits for Fear
    • 00:28:24 Controlling Fear: Top-Down Processing
    • 00:32:27 Narratives: “Protective or Dangerous”
    • 00:35:58 Attaching Fear to Events: Classical Conditioning & Memory
    • 00:41:45 How Fear Learning Occurs: Long Term Potentiation, NMDA
    • 00:46:10 Extinguishing (Reducing) Fears
    • 00:50:25 Cognitive (Narrative) Therapies for Fear
    • 00:57:56 Repetition of Narrative, Overwriting Bad Experiences with Good
    • 01:05:28 EMDR: Eye Movement Desensitization Reprocessing
    • 01:14:00 Social Connection & Isolation Are Chemically Powerful
    • 01:18:23 Trans-Generational Trauma
    • 01:25:00 PTSD Treatments: Ketamine, MDMA, oxytocin
    • 01:39:25 How Do You Know If You Are Traumatized?
    • 01:46:16 Deliberate Brief Stress Can Erase Fears & Trauma
    • 01:49:50 Erasing Fears & Traumas In 5 Minutes Per Day
    • 01:59:42 Nutrition, Sleep, & Other General Support Erasing Fear & Trauma
    • 02:02:30 Supplements for Anxiety, Fear: Saffron, Inositol, Kava
    • 02:10:00 Synthesis
    • 02:11:46 Zero-Cost Support, Sponsors, Patreon, Supplements, Instagram, Twitter

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    Dr. David Buss: How Humans Select & Keep Romantic Partners in Short & Long Term | Episode 48 Nov 29, 2021

    In this episode, my guest is Dr. David Buss, Professor of Psychology at the University of Texas, Austin, and one of the founding members of the field of evolutionary psychology.

    Dr. Buss describes his work on how people select mates for short and long-term relationships, the dynamics of human courtship, and mate value assessment — meaning how people measure up as potential partners. We also discuss the causes of infidelity and differences for infidelity in men and women. He explains how people evaluate and try to alter other people’s mate value as a means to secure and even poach mates. We discuss monogamous and non-monogamous relationships in humans. And we discuss what Dr. Buss calls “the dark triad”— features common in stalkers and narcissists that relate to sexual and psychological violence in relationships.

    This episode is sure to be of interest to anyone single or in a relationship who seeks to know how people select mates and anyone who is interested in forming and maintaining healthy romantic partnerships.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • https://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Dr. Buss' New Book "When Men Behave Badly" - https://amzn.to/3FThTsG
    • Dr. Buss' Website at University of Texas, Austin - https://labs.la.utexas.edu/buss/david-buss/
    • Dr. Buss' Twitter - https://twitter.com/ProfDavidBuss

    Timestamps:

    • 00:00:00 Introducing Dr. David Buss
    • 00:04:10 Sponsors: ROKA, InsideTracker, Headspace
    • 00:08:33 Choosing a Mate
    • 00:13:40 Long Term Mates: Universal Desires
    • 00:18:31 What Women & Men Seek in Long-Term Mates
    • 00:25:10 Age Differences & Mating History
    • 00:32:20 Deception in Courtship
    • 00:37:30 Emotional Stability
    • 00:38:40 Lying About Long-Term Interest
    • 00:41:56 Short-Term Mating Criteria, Sliding Standards & Context Effects
    • 00:46:25 Sexual Infidelity: Variety Seeking & (Un)happiness & Mate Switching
    • 00:54:25 Genetic Cuckolds, How Ovulation Impacts Mate Preference
    • 00:57:00 Long-Term vs. Short-Term Cheating, Concealment
    • 00:59:15 Emotional & Financial Infidelity
    • 01:04:35 Contraception
    • 01:06:22 Status & Mating Success
    • 01:10:10 Jealousy, Mate Value Discrepancies, Vigilance, Violence
    • 01:24:13 Specificity of Intimate Partner Violence
    • 01:25:12 Mate Retention Tactics: Denigration, Guilt, Etc.
    • 01:27:33 Narcissism, Machiavellianism, Psychopathy
    • 01:33:25 Stalking
    • 01:39:15 Influence of Children on Mate Value Assessments
    • 01:43:24 Attachment Styles, Mate Choice & Infidelity
    • 01:46:40 Non-Monogamy, Unconventional Relationships
    • 01:54:00 Mate Value Self Evaluation, Anxiety About the Truth
    • 02:02:12 Self Deception
    • 02:05:35 The Future of Evolutionary Psychology & Neuroscience
    • 02:06:56 Books: When Men Behave Badly; The Evolution of Desire, Textbooks
    • 02:10:42 Concluding Statements, Zero-Cost Support: Subscribe, Sponsors, Patreon, Thorne

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    The Science of Gratitude & How to Build a Gratitude Practice | Episode 47 Nov 22, 2021

    In this episode, I discuss the science of gratitude, which has been shown in peer-reviewed studies to have tremendous positive effects on mental and physical health. I explain, however, that most commonly used gratitude practices are ineffective (such as gratitude lists). The key elements of highly effective gratitude practices are described, including the essential need for story (narrative), receiving or perceiving gratitude rather than giving it, and the role that theory of mind plays in this context. I also discuss why we can't simply make up feelings of gratitude and how reluctance undermines the process. I also explain the neural circuit mechanisms that underlie the reductions in fear and increases in motivation and lowering of inflammatory chemicals that effective narrative-based gratitude can trigger. Throughout the episode, I use the science of gratitude to design a brief but highly effective protocol.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Magic Spoon - https://www.magicspoon.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • https://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Neural Correlates of Gratitude (Damasio) - https://bit.ly/3oS8TNr
    • Reducing Inflammatory Cytokines & Fear With Gratitude - https://bit.ly/3oPsSwv

    Timestamps:

    • 00:00:00 Introduction: Gratitude Science & Surprises
    • 00:01:50 Controlling Heart Rate with Story
    • 00:04:33 Sponsors: ROKA, InsideTracker, Magic Spoon
    • 00:09:11 Major, Long-Lasting Benefits of Gratitude Practice
    • 00:12:20 Prosocial vs. Defensive Thinking, Behaviors, & Neural Circuits
    • 00:17:50 Why We All Need an Effective Gratitude Practice
    • 00:21:22 Neurochemistry & Neural Circuits of Gratitude
    • 00:25:10 Prefrontal Cortex Set Context
    • 00:30:10 Ineffective Gratitude Practices; Autonomic Variables
    • 00:34:55 Key Features of Effective Gratitude Practices: Receiving Thanks & Story
    • 00:42:30 Theory of Mind Is Key
    • 00:45:50 Building Effective Gratitude Practices: Adopting Narratives, Duration
    • 00:52:28 Narratives That Shift Brain-Body Circuits
    • 00:56:15 You Can’t Lie About Liking Something; Reluctance In Giving
    • 00:59:55 How Gratitude Changes Your Brain: Reduces Anxiety, Increases Motivation
    • 01:03:00 5 Minutes (Is More Than Enough), 3X Weekly, Timing Each Day
    • 01:05:44 Empathy & Anterior Cingulate Cortex
    • 01:07:35 Reducing Inflammation & Fear with Gratitude
    • 01:10:56 Serotonin, Kanna/Zembrin
    • 01:16:00 Neuroplasticity, Pharmacology, Brain Machine Interfaces
    • 01:18:50 The Best Gratitude Practices: & How To, My Protocol
    • 01:24:25 Subscribe & Feedback, Supporting Sponsors, Supplements (Thorne)

    Time Perception & Entrainment by Dopamine, Serotonin & Hormones | Episode 46 Nov 15, 2021

    In this episode, I discuss how our brain and body track time and the role that neurochemicals, in particular dopamine and serotonin, but also hormones such as melatonin, allow us to orient ourselves in time. I review the three types of time perception: of the past, of the present, and the future, and how dopamine and serotonin adjust both our perception of the speed of the passage of time and our memory of how long previous experiences lasted. I also discuss circannual entrainment, which is the process by which our brain and body are matched to the seasons, and circadian (24 hours) entrainment, both of which subconsciously adjust our perceived measurement of time. I explain the mechanisms of that subconscious control. And I cover the ultradian (90 minutes) rhythms that govern our ability to focus, including how to track when these 90-minute rhythms begin and end for the sake of work and productivity. I include ten tools based on the science of time perception that you can apply to enhance productivity, creativity, and relationships in various contexts.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code "huberman"
    • Athletic Greens - https://www.athleticgreens.com/huberman
    • InsideTracker - https://www.insidetracker.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Introducing Time Perception, Note on Fasting & Supplements
    • 00:05:12 Sponsors: ROKA, Athletic Greens, InsideTracker
    • 00:09:25 Entrainment, Circannual Entrainment, Melatonin
    • 00:13:20 Seasonal Oscillations in Testosterone & Estrogen, Tool 1
    • 00:16:06 Circadian Timing, Tools 1, 2, 3 (for Circadian Entrainment)
    • 00:21:13 Tool 4: Timing Physical Activity; Tool 5: Timing Eating Window
    • 00:23:00 When Circadian Entrainment is Disrupted, Time Perception Suffers
    • 00:25:00 Tool 6: Ultradian (90min) Cycles & Focus
    • 00:31:42 Our Sense of the Passage of Time: Present, Prospective, Retrospective
    • 00:34:40 Dopamine (& Nor/epinephrine) Lead to Time Overestimation; Frame Rate
    • 00:37:18 Serotonin & Time Underestimation; Decreased Frame Rate
    • 00:39:10 Dopamine vs. Serotonin Across the Day; Tool 7: When to Do Rigid vs. Creative Work
    • 00:42:38 Example of Tool 7
    • 00:43:38 How Sleep Deprivation Degrades Performance
    • 00:44:38 Trauma, “Over-clocking” & Memories; Adjusting Rates of Experience
    • 00:50:04 Why Trauma Involves Dopamine & Epinephrine, Arousal
    • 00:51:03 Dopamine, Spontaneous Blinking & Time Perception; Tool 8
    • 00:53:38 Deliberate Cold Exposure, Dopamine, Tool 9: Adjusting Frame Rate in Discomfort
    • 00:56:30 Fun “Feels Fast” BUT Is Remembered as Slow; Boring Stuff “Feels Slow,” Recall As Fast
    • 01:00:54 Retrospective Time, Context Variation & Enhanced Bonding with Places & People
    • 01:03:00 Dopamine Release Resets the Start of Each Time Bin on Our Experience
    • 01:07:40 Habits & Time Perception; Tool 10 (Setting Functional Units of Each Day)
    • 01:11:58 Synthesis & Book Suggestion (Your Brain Is a Time Machine by D. Buonomano)
    • 01:12:27 Supporting the HLP: Subscribe, Instagram, Patreon, Thorne Supplements

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    Dr. Duncan French: How to Exercise for Strength Gains & Hormone Optimization | Episode 45 Nov 08, 2021

    In this episode, I talk to Dr. Duncan French, Ph.D., the Vice President of Performance at the UFC Performance Institute and a world-class performance specialist. We discuss specific resistance (weight) training regimens for increasing testosterone in men and women and how to vary mechanical loads and rest between sets and workouts to optimize hormone output and training results. We also discuss how stress-induced "catecholamines" can increase testosterone or decrease it, depending on duration and mindset. And we discuss specific cold- and heat- therapies for increasing resilience, reducing inflammation, heat shock proteins and more. We discuss nutrition for training and how to match nutrition to training goals and metabolic flexibility. We discuss mental focus and how long to train for skill development. Finally, we discuss how mixed martial arts and the UFC Performance Institute are a template for exploring human performance more generally. This episode is intended for anyone interested in athletic and mental performance: athletes, students, and recreational exercisers and includes both science and many practical tools people can apply in their own training.

    Thank you to our sponsors:

    • ROKA - https://roka.com/ -- code "huberman"
    • Helix - https://helixsleep.com/huberman
    • Headspace - https://headspace.com/specialoffer

    Dr. Duncan French:

    • Instagram - https://www.instagram.com/dr_duncan_french
    • LinkedIn - https://www.linkedin.com/in/duncan-french-phd-a41bb9122

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Dr. Duncan French
    • 00:02:27 Roka, Helix Sleep, Headspace
    • 00:05:44 Duncan’s Background in Exercise Science
    • 00:11:45 How Certain Exercises Increase Testosterone
    • 00:16:22 What Kind of Training Increases Testosterone & Growth Hormone?
    • 00:20:19 Intensity: Mechanical Load; Volume: Metabolic Load; Inter-set Rest Periods
    • 00:25:25 Training Frequency & Combining Workout Goals
    • 00:29:35 How Stress Can Increase or Decrease Testosterone
    • 00:36:55 Using Cold Exposure for Mindset, Anti-Inflammation, Muscle-Growth
    • 00:46:55 Skill Development
    • 00:50:05 Why Hard Exercise Creates Brain Fog: Role of Nutrition
    • 00:53:55 Low-Carbohydrate Versus All-Macronutrient Diets on Performance
    • 00:56:15 Ketones & Brain Energy, Offsetting Brain Injury; Spiking Glucose During Ketosis
    • 00:59:13 Metabolic Efficiency, Matching Nutrition to Training, “Needs Based Eating”
    • 01:05:00 Duncan’s Work with Olympic Athletes, NCAA, UFC (Ultimate Fighting Championship)
    • 01:08:00 Why UFC & MMA (Mixed-Martial Arts) Are So Valuable for Advancing Performance
    • 01:12:40 Voluntarily Switching Between Different States of Arousal
    • 01:14:30 Heat, Getting Better at Sweating, Heat Shock Proteins, Sauna
    • 01:20:12 Using Rotating 12-Week Training Programs; Logging Objective & Subjective Data
    • 01:24:07 Surprising & Unknown Aspects of The UFC and UFC Performance Institute
    • 01:27:45 Conclusions, Zero-Cost Support, Sponsors, Supplements, Instagram

    Using Your Nervous System to Enhance Your Immune System | Episode 44 Nov 01, 2021

    This episode teaches you a lot about the immune system, immune-brain interactions and offers 12 potential tools for enhancing immune system function. I discuss how our immune system works and science-supported tools we can use to enhance our immune system.

    I discuss the innate and adaptive immune systems and our various microbiomes-- not just in our gut but also in our nose, eyes and mouth and how to keep them healthy. And I review how specific patterns of breathing and foods maintain a healthy mucosal barrier that is crucial for fighting infections. I discuss how certain neurochemicals called catecholamines enhance our immune system function and how to use specific breathing protocols, types and timing of heat and cold exposure, and, if appropriate, supplementation to activate catecholamines. I also discuss the role and use of serotonin for the sake of accessing the specific types of sleep for recovering from illness, and I discuss how to increase glymphatic "washout" of brain debris during sleep. I also review fever, the vagus nerve and the use of atypical yet highly effective compounds for rhinitis (nasal inflammation).

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code: "huberman"
    • Athletic Greens - https://www.athleticgreens.com/huberman
    • InsideTracker - https://www.insidetracker.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • How and Why The Immune System Makes Us Sleep - https://www.nature.com/articles/nrn2576

    Timestamps:

    • 00:00:00 The Mind & Immune System, New Findings: Acupuncture & Fascia
    • 00:03:00 Sponsors: ROKA, Athletic Greens, InsideTracker
    • 00:07:41 Foundational Tools & Practices for a Healthy Immune System
    • 00:11:20 Immune System Basics: Skin/Mucous, Innate & Adaptive Immune System
    • 00:17:08 Killer Cells, Complement Proteins (“Eat Me!” Signals), Cytokines (“Help Me!” Signals)
    • 00:21:06 The Adaptive Immune System: Antibodies
    • 00:28:00 Tool 1: Nasal Microbiome and “Scrubbing” Bacteria & Viruses; Nasal Breathing
    • 00:30:33 Tools 2 & 3: (Not) Touching Your Eyes; Gut Microbiome & Fermented Foods
    • 00:34:20 Some Interleukins Are Anti-Inflammatory
    • 00:34:56 Sickness Behavior
    • 00:39:08 Some People Seek Care When Sick, Others Want to be Alone
    • 00:42:00 Sickness Behavior & Depression: Cytokines
    • 00:43:40 Reduced Appetites When Sick: Protein, Iron, Libido
    • 00:46:45 Vagus-Nerve Stimulation: Fever, Photophobia, Sleepiness
    • 00:53:03 Humoral (Blood-Borne) Factors, & Choroid Change Your Brain State
    • 00:55:04 Tools 4, 5: Reducing Sickness: Glymphatic Clearance, Pre-Sleep Serotonin, 5HTP
    • 01:07:03 Tool 6: Hot Showers, Saunas, Baths & Cortisol, Heath-Cold Contrast
    • 01:10:53 Feed a Fever & Starve a Cold (?), Adrenaline
    • 01:12:36 Tool 7: Activating Your Immune System w/Cyclic-Hyperventilation, Alkalinity
    • 01:29:10 Brain Chemicals & Cyclic-Hyperventilation; Catecholamines, Dopamine
    • 01:32:10 Mindsets & Immune Function; Yes, You Can Worry Yourself Sick
    • 01:37:00 Tool 8: Healthy Mindsets, Hope, Dopamine; Tool 9: Tyrosine; Tool 10: Cold Exposure
    • 01:42:05 Once You’re Already Sick: Accelerating Recovery; Tool 11: Spirulina, Rhinitis
    • 01:46:09 Histamines, Mast Cells
    • 01:49:22 Tool 12: Acupuncture: Mechanism for How It Reduces Inflammation; Fascia, Rolfing
    • 01:53:40 Mechanistic Science & Ancient Practices
    • 01:58:00 Synthesis, Ways to Support Us (Zero-Cost), Sponsors, Supplements, Social Media

    Dr. Samer Hattar: Timing Your Light, Food, & Exercise for Optimal Sleep, Energy & Mood | Episode 43 Oct 25, 2021

    In this episode, I host Dr. Samer Hattar, Chief of the Section on Light and Circadian Rhythms at the National Institute of Mental Health. Dr. Hattar is a world-renowned expert on how viewing light at particular times adjusts our mood, ability to learn, stress and hormone levels, appetite, and mental health. We discuss how to determine and use your individual light sensitivity to determine the optimal sleep-wake cycle for you. We also discuss how to combine your light viewing and waking time with the timing of your food intake and exercise in order to maximize mental and physical functioning. Dr. Hattar is credited with co-discovering the neurons in the eye that set our circadian clocks and regulate mood and appetite. He explains why even a small shift in daylight savings leads to outsized effects on our biking because of the way that our cells and circadian clocks integrate across many days. And he offers precise tools to rapidly adjust to jetlag, shift work, and reset your clock after a late night of work or socializing. This episode is filled with cutting-edge data on the biological mechanisms of human physiology and practical tools for people of all ages.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code: "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Magic Spoon - https://www.magicspoon.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Samer Hattar:

    • Twitter
    • Instagram
    • Wikipedia

    Links:

    • Graphical Explanation of Temperature Minimum for Overcoming Jetlag

    Timestamps:

    • 00:00:00 Introducing Dr. Samer Hattar, Ph.D.
    • 00:02:17 Sponsors: ROKA, InsideTracker, Magic Spoon
    • 00:06:15 Light, Circadian (24 hour) & Circannual (365 day) “Photoentrainment”
    • 00:14:30 Neurons in Our Eyes That Set Our Body Clocks: Similar to Frog Skin
    • 00:18:55 What Blind People See
    • 00:20:15 When, How & How Long to View Light for Optimal Sleep & Wakefulness
    • 00:30:20 Sunlight Simulators, Afternoon Light Viewing, Naps
    • 00:33:48 Are You Jetlagged at Home? Chronotypes & Why Early Risers Succeed
    • 00:38:33 How to Decide Your Best Sleep-Wake Schedule; Minimal Light Test
    • 00:42:16 Viewing Light in Middle of Day: Mood & “Light Hunger”
    • 00:44:55 Evening Sunlight; Blueblocker Warning
    • 00:48:57 Blue Light Is Not the Issue; Samer’s Cave; Complete Darkness
    • 00:53:58 Screens at Night
    • 00:56:03 Dangers of Bright Light Between 10 pm and 4 am: Mood & Learning
    • 01:01:05 The Tripartite Model: Circadian, Sleep Drive, Feeding Schedules
    • 01:05:05 Using Light to Enhance Your Mood; & The Hattar-Hernandez Nucleus
    • 01:07:19 Why Do We Sleep?
    • 01:08:17 Effects of Light on Appetite; Regular Light & Meal Times
    • 01:18:08 Samer’s Experience with Adjusting Meal Timing
    • 01:22:51 Using Light to Align Sleep, Mood, Feeding, Exercise & Cognition
    • 01:30:15 Age-Related Changes in Timing of Mental & Physical Vigor
    • 01:31:44 “Chrono-Attraction” in Relationships; Social-Rhythms
    • 01:33:40 Re-setting Our Clock Schedule; Screen Devices Revisited
    • 01:37:50 How Samer Got into the Study of Light
    • 01:39:33 Clock Gene mRNAs & More Accurate Biomarkers
    • 01:41:08 Light as Medicine
    • 01:42:48 ADHD (Attention-Deficit Hyperactivity Disorder)
    • 01:43:35 How to Beat Jetlag: Light, Temperature, Eating
    • 01:50:44 Vigor: The Consequence of Proper Timing
    • 01:52:15 Waking in the Middle of the Night: When Your Nightly Sleep Becomes a Nap
    • 01:54:10 Melatonin, Pineal Calcification
    • 01:55:25 Our Seasonal Rhythms: Mood, Depression, Lethargy & Reproduction
    • 01:59:08 Daylight Savings: Much Worse Than It Might Seem
    • 02:05:27 Eye Color & Sensitivity to Light, Bipolar Disorder
    • 02:09:28 Spicy Food, Genetic Variations in Sensory Sensitivity
    • 02:10:52 Synthesizing This Information, Samer on Twitter, Instagram
    • 02:13:00 Conclusions, Ways To Support the Huberman Lab Podcast & Research

    Nutrients For Brain Health & Performance | Episode 42 Oct 18, 2021

    This episode I describe science-supported nutrients for brain and performance (cognition) and for nervous system health generally.

    I describe 10 tools for this purpose, including specific amounts and sources for Omega-3 fatty acids which make up the "structural fat" of neurons (nerve cells) and allow them to function across our lifespan. I also review data on creatine, phosphatidylserine, anthocyanins, choline, glutamine and how they each impact brain function in healthy people seeking to reinforce and improve their cognition and in those combatting cognitive decline. I describe both food-based and supplement-based sources for these compounds, and their effective dose ranges based on peer-reviewed literature.

    Then I review the 3 factors: gut-brain signaling, perceived taste, and learned associations that combine with the metabolic and blood-sugar-elevating effects of food to determine what foods we seek and prefer. Amazingly, it's not just about what tastes good to us. Next, I explore how we can leverage the neural circuits of learned food preference toward seeking and enjoying the right foods for brain health and performance. I also review new data on non-caloric sweeteners and why consuming them with glucose-elevating foods can be detrimental, in some cases rapidly leading to insulin dysregulation. This episode covers more than 10 actionable tools for those seeking to improve and/or maintain brain function, and it explains modern neuroscience underlying of our sense of taste, our food seeking preferences and brain metabolism.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code: "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    RETHINK EDUCATION: The Biology of Learning Featuring Dr. Andrew Huberman:

    • https://youtu.be/Oo7hQapFe3M

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Links:

    • Review on Anthocyanins and Cognition
    • Review on Creatine & Brain Health Studies
    • Review on "Rethinking Food Reward"

    Timestamps:

    • 00:00:00 Food & Brain Function Introduction
    • 00:02:08 Summary: Critical Aspects of Time Restricted Feeding/Fasting
    • 00:04:19 Sponsors: ROKA, Athletic Greens, Headspace
    • 00:08:24 Neuroplasticity Super Protocol (Zero-Cost Tools) Online
    • 00:09:22 Eating to Enhance Brain Function & Foundational Aspects of Brain Health
    • 00:13:00 Eating Fats for Brain Health, EFAs Phospholipids (Tool 1: 1-3g EPA Omega-3/day)
    • 00:20:35 Phosphatidylserine (Tool 2: 300mg/day)
    • 00:22:15 Choline, Egg Yolks (Tool 3: 1-2g/day Threshold)
    • 00:28:26 Hydration & Electrolytes (Tool 4)
    • 00:29:50 Liquid Fish Oil/Capsules (2-3g EPA per day; 300mg Alpha GPC 2-4X/week)
    • 00:32:22 Creatine for Cognition (Tool 5: 5g/day)
    • 00:36:28 Anthocyanins, Dark Skin Berries (Tool 6-10mg/day (Extract), 1-2 cups Berries)
    • 00:41:19 L-Glutamine (Tool: 1-10g/day) & Offsetting Apnea & Inflammation
    • 00:49:23 Neural Basis of Food Preference, Yum, Yuck, Meh; Taste, Guts, & Beliefs
    • 00:55:25 Taste is 100% In your Head
    • 00:59:50 Gut Neurons Controlling Food Preference: Neuropod Cells; (Tool 7: Fermented Foods)
    • 01:06:14 Capsule Probiotics, Brain Fog
    • 01:07:16 Learning to Like Specific Tastes: Sweetness & Brain Metabolism
    • 01:12:11 Hard-Wiring & Soft-Wiring
    • 01:13:25 Artificial & Non-Caloric Sweeteners: Safe or Harmful Depends on (Glucose) Context
    • 01:18:15 Non-Caloric Sweetener & Insulin; (Tool 8: Don’t Have w/Glucose Elevating Foods)
    • 01:22:17 Beliefs & Thoughts; The Insula; (Tool 9: Pairing-Based Reshaping Food Preferences)
    • 01:30:42 Liking Neuro-Healthy Foods & Bettering Brain Metabolism (Tool 10); Food Wars
    • 01:36:05 Food Reward & Diabetes, Obesity; Important Review Article (See Caption)
    • 01:38:28 Synthesis, Zero-Cost Support, Future Topic Suggestions, Sponsors, Supplements

    Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Episode 41 Oct 11, 2021

    This episode I discuss the science and practice of fasting also called time-restricted feeding. I review the data on how limiting food intake to specific portions of every 24-hour cycle (or fasting longer) impacts weight loss, fat loss specifically, liver health, mental focus, muscle, longevity and more. I explain how "fasted" is contextual, and relates to blood glucose levels and their downstream effects, and how the depth of fasting can be adjusted with behaviors such as different types of exercise, or with glucose disposal agents. I also discuss the optimal fasting protocol: and both the absolute (non-negotiable) and variable (contextual) features of a fasting/time-restricted-feeding protocol that will allow you to get the most benefits. I also discuss what does and does not break a fast, the effects of fasting on hormones like testosterone and cortisol and on fertility. I also review how different feeding windows of 8 or 10 or 4 hours differentially impact the effects of fasting, and why the classic 8 hour feeding window came to be but also might be ideal. I discuss mechanisms and offer tools to discern the optimal fasting duration and timing for you.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code: "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Helix Sleep - https://www.helixsleep.com/huberman

    RETHINK EDUCATION: The Biology of Learning Featuring Dr. Andrew Huberman

    • https://youtu.be/Oo7hQapFe3M

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Comprehensive Review On Fasting In Humans: https://bit.ly/3BwIyd7

    Timestamps:

    • 00:00:00 Introduction, Blood Glucose & Mortality, Mice Vs. Humans
    • 00:06:02 Sponsors: Roka, InsideTracker, Helix
    • 00:09:42 Neuroplasticity Protocols & Online Lecture https://youtu.be/Oo7hQapFe3M
    • 00:11:20 Feeding, Fasting, Performance
    • 00:13:50 Calories-In, Calories-Out (CICO); Perfect Diets
    • 00:19:48 Feeding-Induced Health Conditions
    • 00:25:33 Time Restricted Eating: When We Eat Is Vital
    • 00:29:45 The Eight Hour Feeding Window
    • 00:31:26 Feeding Deep Into the Night Is Bad (In Humans)
    • 00:36:33 Liver Health
    • 00:39:45 Time Restricted Feeding Protocol: Rules
    • 00:41:35 When to Start & Stop Eating
    • 00:45:38 Gastric Clearance, Linking Fasting to Sleep
    • 00:52:35 Effects of Specific Categories of Food
    • 00:55:40 Precision In Fasting: Protocol Build
    • 00:59:30 4-6 Hour Feeding Windows
    • 01:03:08 Protein Consumption & Timing for Muscle
    • 01:08:13 How to Shift Your Eating Window
    • 01:13:20 Glucose Clearing, Exercise & Compounds
    • 01:22:37 Blood Glucose: Monitoring, mTOR & Related Pathways
    • 01:27:40 Gut Health: Fasting, Clock Genes and Microbiota
    • 01:29:15 Non-Alcoholic Fatty Liver
    • 01:32:00 Effects of Fasting on Hormones: Testosterone, Cortisol
    • 01:38:40 Fertility
    • 01:41:50 8-Hour Feeding Window: Weight Loss Without Calorie Counting
    • 01:43:20 Eating Every-Other-Day
    • 01:45:29 Adherence
    • 01:47:15 Mental Focus & Clarity
    • 01:49:12 Enhancing Weight Loss from Body Fat: Hepatic Lipase
    • 01:53:15 What Breaks a Fast? Rules & Context
    • 01:58:50 Artificial Sweeteners, Plant-Based Sweeteners
    • 02:01:42 Glucose Clearing II, Cinnamon, Acidity, Salt
    • 02:06:42 My Circadian Clock, Zero-App
    • 02:08:20 Odd (But Common) Questions
    • 02:09:23 Effects of Sauna & Dehydration on Blood Glucose
    • 02:11:12 The Ideal Fasting Protocol
    • 02:24:00 More Resources, Ways to Support Us, Supplements

    Dr. Craig Heller: Using Temperature To Optimize Performance, Brain & Body Health | Episode 40 Oct 04, 2021

    This episode I am joined by Dr. Craig Heller, Professor of Biology at Stanford University and world expert on the science of temperature regulation. We discuss how the body and brain maintain temperature under different conditions and how most everyone uses the wrong approach to cool off or heat up. Dr. Heller teaches us the best ways and in doing so, explains how to offset hyperthermia and hypothermia. He also explains how we can use the precise timing and location of cooling on our body to greatly enhance endurance and weight training performance. He describes how cooling technology discovered and engineered in his laboratory has led to a tripling of anaerobic (weight training) performance and allowed endurance athletes to run further and faster, as well as to eliminate delayed onset muscle soreness. Dr. Heller explains how heat impairs muscular and mental performance, and how to cool the brain to reduce inflammation and to enhance sleep and cognition. We discuss how anyone can apply these principles for themselves, even their dogs! Our conversation includes both many practical tools and mechanistic science.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman

    Support Research in Huberman Lab at Stanford:

    • https://hubermanlab.stanford.edu/giving

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Links:

    • Dr. Heller's Website - https://profiles.stanford.edu/h-craig-heller
    • CoolMitt Technology - https://www.coolmitt.com

    Timestamps:

    • 00:00:00 Introducing Dr. Craig Heller, Physiology & Performance
    • 00:02:00 Sponsors: Roka, Inside Tracker, Athletic Greens
    • 00:06:45 Cold Showers, Ice Baths, Cryotherapy
    • 00:10:45 Boundary Layers
    • 00:11:55 Cooling Before Aerobic Activity to Enhance Performance
    • 00:14:45 Anaerobic Activity Locally Increases Muscle Heat
    • 00:16:45 Temperature Gates Our Energy Use
    • 00:19:00 Local Versus Systemic Fatigue: Heat Is Why We Fail
    • 00:22:10 Cooling Off: Most Methods are Counterproductive
    • 00:26:43 Exercise-Induced Brain Fog
    • 00:27:45 Hyperthermia
    • 00:31:50 Best Body Sites for Cooling: Palms, Foot Pads, Upper Face
    • 00:38:00 Cooling Your Brain via The Upper Face; Concussion
    • 00:41:25 Extraordinary (Tripling!) Performance by Cooling the Palms
    • 00:45:35 Enhancing Recovery, Eliminating Soreness w/Intra-workout Cooling
    • 00:50:00 Multiple Sclerosis: Heat Sensitivity & Amelioration with Cooling
    • 00:51:00 Enhancing Endurance with Proper Cooling
    • 00:53:00 Cool Mitt, Ice-Cold Is Too Cold, 3 Minutes Cooling
    • 00:58:20 How You Can Use Palmer Cooling to Enhance Performance
    • 01:01:15 Radiation, Convection, Heat-Transfer, Role of Surface Area
    • 01:04:40 Hypothermia Story, Ideal Re-Heating Strategy
    • 01:11:40 Paw-lmer Cooling for Dog Health & Performance
    • 01:12:45 Warming Up, & Varying Temperature Around the Body
    • 01:17:35 Cooling-Enhanced Performance Is Permanent
    • 01:19:55 Anabolic Steroids versus Palmer Cooling
    • 01:24:00 Female Athletic Performance
    • 01:25:18 Shivering & Cold, Metabolism
    • 01:26:55 Studies of Bears & Hibernation, Brown Fat
    • 01:31:10 Brown Fat Distribution & Activation In Humans
    • 01:34:18 Brain Freeze, Ice Headache: Blood Pressure, Headache
    • 01:37:50 Fidgeters, Non-Exercise Induced Thermogenesis
    • 01:39:44 How Pre-Workout Drinks, & Caffeine May Inhibit Performance
    • 01:43:42 Sleep, Cold, Warm Baths, Screens, & Socks
    • 01:48:44 Synthesis
    • 01:49:30 Supporting the Podcast & Scientific Research

    Controlling Your Dopamine For Motivation, Focus & Satisfaction | Episode 39 Sep 27, 2021

    This episode serves as a sort of “Dopamine Masterclass”. I discuss the immensely powerful chemical that we all make in our brain and body: dopamine. I describe what it does and the neural circuits involved. I explain dopamine peaks and baselines, and the cell biology of dopamine depletion. I include 14 tools for how to control your dopamine release for sake of motivation, focus, avoiding and combating addiction and depression, and I explain why dopamine stacking with chemicals and behaviors inevitably leads to states of underwhelm and poor performance. I explain how to achieve sustained increases in baseline dopamine, compounds that injure and protect dopamine neurons including caffeine from specific sources. I describe non-prescription supplements for increasing dopamine—both their benefits and risks—and synergy of pro-dopamine supplements with those that increase acetylcholine.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code "huberman"
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Logitech Event - Rethink Education: The Biology of Learning

    • Thursday, Sept. 30 at 12pm PT / 3pm ET
    • Sign up here: https://info.logitech.com/ReThink-Education.html

    Support Research in Huberman Lab at Stanford:

    • https://hubermanlab.stanford.edu/giving

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Links:

    • Review on Dopamine: https://www.nature.com/articles/s41583-021-00455-7
    • Cold Exposure & Dopamine: https://link.springer.com/article/10.1007%2Fs004210050065

    Timestamps:

    • 00:00:00 Introduction & Tool 1 to Induce Lasting Dopamine
    • 00:04:48 Sponsors: Roka, InsideTracker, Headspace
    • 00:09:10 Upcoming (Zero-Cost) Neuroplasticity Seminar for Educators
    • 00:09:58 What Dopamine (Really) Does
    • 00:15:30 Two Main Neural Circuits for Dopamine
    • 00:18:14 How Dopamine Is Released: Locally and Broadly
    • 00:22:03 Fast and Slow Effects of Dopamine
    • 00:25:03 Dopamine Neurons Co-Release Glutamate
    • 00:28:00 Your Dopamine History Really Matters
    • 00:30:30 Parkinson’s & Drugs That Kill Dopamine Neurons. My Dopamine Experience
    • 00:36:58 Tool 3 Controlling Dopamine Peaks & Baselines
    • 00:40:06 Chocolate, Sex (Pursuit & Behavior), Nicotine, Cocaine, Amphetamine, Exercise
    • 00:46:46 Tool 4 Caffeine Increases Dopamine Receptors
    • 00:49:54 Pursuit, Excitement & Your “Dopamine Setpoint”
    • 00:56:46 Your Pleasure-Pain Balance & Defining “Pain”
    • 01:00:00 Addiction, Dopamine Depletion, & Replenishing Dopamine
    • 01:07:50 Tool 5 Ensure Your Best (Healthy) Dopamine Release
    • 01:15:28 Smart Phones: How They Alter Our Dopamine Circuits
    • 01:19:45 Stimulants & Spiking Dopamine: Counterproductive for Work, Exercise & Attention
    • 01:22:20 Caffeine Sources Matter: Yerba Mate & Dopamine Neuron Protection
    • 01:24:20 Caffeine & Neurotoxicity of MDMA
    • 01:26:15 Amphetamine, Cocaine & Detrimental Rewiring of Dopamine Circuits
    • 01:27:57 Ritalin, Adderall, (Ar)Modafinil: ADHD versus non-Prescription Uses
    • 01:28:45 Tool 6 Stimulating Long-Lasting Increases in Baseline Dopamine
    • 01:37:55 Tool 7 Tuning Your Dopamine for Ongoing Motivation
    • 01:47:40 Tool 8 Intermittent Fasting: Effects on Dopamine
    • 01:53:09 Validation of Your Pre-Existing Beliefs Increases Dopamine
    • 01:53:50 Tool 9 Quitting Sugar & Highly Palatable Foods: 48 Hours
    • 01:55:36 Pornography
    • 01:56:50 Wellbutrin & Depression & Anxiety
    • 01:58:30 Tool 10 Mucuna Pruriens, Prolactin, Sperm, Crash Warning
    • 02:01:45 Tool 11 L-Tyrosine: Dosages, Duration of Effects & Specificity
    • 02:05:20 Tool 12 Avoiding Melatonin Supplementation, & Avoiding Light 10pm-4am
    • 02:07:00 Tool 13 Phenylethylamine (with Alpha-GPC) For Dopamine Focus/Energy
    • 02:08:20 Tool 14 Huperzine A
    • 02:10:02 Social Connections, Oxytocin & Dopamine Release
    • 02:12:20 Direct & Indirect Effects: e.g., Maca; Synthesis & Application
    • 02:14:22 Zero-Cost & Other Ways To Support Podcast & Research

    Dr. Matthew Johnson: Psychedelics for Treating Mental Disorders | Episode 38 Sep 20, 2021

    This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.

    Thank you to our sponsors:

    • Athletic Greens - http://www.athleticgreens.com/huberman
    • Belcampo - http://www.belcampo.com/huberman
    • InsideTracker - http://www.insidetracker.com/huberman

    Dr. Matthew Johnson Social Media:

    • Twitter: https://twitter.com/drug_researcher
    • Instagram: https://instagram.com/drug_researcher

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Dr. Johnson’s Website at Johns Hopkins School of Medicine - https://hopkinspsychedelic.org/johnson
    • Chris Letheby’s forthcoming book - https://amzn.to/3nMTaAs

    Timestamps:

    • 00:00:00 Introducing Dr. Matthew Johnson
    • 00:02:10 Supporting Sponsors
    • 00:06:40 ‘Psychedelics’ Defined
    • 00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception
    • 00:19:56 Serotonin & Dopamine
    • 00:23:50 Ketamine & Glutamate
    • 00:28:00 An Example Psychedelic Experiment
    • 00:37:30 ‘Letting Go’ with Psychedelics
    • 00:44:10 Our Mind’s Eye
    • 00:48:00 Redefining Your Sense of Self
    • 00:58:56 Exporting Psychedelic Learnings to Daily Life
    • 01:04:36 Flashbacks
    • 01:12:10 Ayahuasca, & ASMR, Kundalini Breathing
    • 01:15:54 MDMA, DMT
    • 01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis
    • 01:38:15 Micro-Dosing
    • 01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials
    • 02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation
    • 02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury
    • 02:27:45 Shifting Trends in Psychedelic Research, Academic Culture
    • 02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork
    • 02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements

    ADHD & How Anyone Can Improve Their Focus | Episode 37 Sep 13, 2021

    In this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD.

    I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD).

    The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered.

    Thank you to our sponsors:

    • Roka - https://www.roka.com -- code "huberman"
    • Belcampo - https://www.belcampo.com/huberman
    • Helix Sleep - https://www.helixsleep.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Support Research in the Huberman Lab at Stanford:

    • https://hubermanlab.stanford.edu/giving

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Email Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Review of Compounds for ADHD, Smart Drugs & Focus - https://www.fbscience.com/Landmark/articles/10.52586/4948
    • Review of Atypical Compounds for ADHD - https://www.hindawi.com/journals/np/2016/1320423/
    • Study of Focus Protocol In ADHD & Non-ADHD Children - https://www.mdpi.com/1660-4601/17/13/4780

    Timestamps:

    • 00:00:00 Introduction & Note About Diagnosis
    • 00:03:27 Sponsors
    • 00:07:56 ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults
    • 00:13:00 Attention & Focus, Impulse Control
    • 00:14:57 Hyper-focus
    • 00:16:45 Time Perception
    • 00:18:25 The Pile System
    • 00:20:00 Working Memory
    • 00:24:10 Hyper-Focus & Dopamine
    • 00:26:40 Neural Circuits In ADHD: Default Mode Network & Task-Related Networks
    • 00:32:57 Low Dopamine in ADHD & Stimulant Use & Abuse
    • 00:37:10 Sugar, Ritalin, Adderall, Modafinil & Armodafinil
    • 00:47:00 Non-Prescribed Adderall, Caffeine, Nicotine
    • 00:49:18 How Stimulants “Teach” the Brains of ADHD Children to Focus
    • 00:52:00 When To Medicate: A Highly Informed (Anecdotal) Case Study
    • 00:56:35 Elimination Diets & Allergies In ADHD
    • 01:04:46 Omega-3 Fatty Acids: EPAs & DHAs
    • 01:07:00 Modulation vs Mediation of Biological Processes
    • 01:10:50 Attentional Blinks
    • 01:16:56 Open Monitoring & 17minute Focus Enhancement
    • 01:22:50 Blinking, Dopamine & Time Perception; & Focus Training
    • 01:30:10 Reverberatory Neural & Physical Activity
    • 01:33:40 Adderall, Ritalin & Blink Frequency
    • 01:35:00 Cannabis
    • 01:37:30 Interoceptive Awareness
    • 01:41:15 Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers
    • 01:48:05 DHA Fatty Acids, Phosphatidylserine
    • 0:1:50:54 Ginko Biloba
    • 01:51:45 Modafinil & Armodafanil: Dopamine Action & Orexin
    • 01:56:19 Acetylcholine: Circuits Underlying Focus; Alpha-GPC
    • 01:59:04 L-Tyrosine, (PEA) Phenylethylamine
    • 02:01:23 Racetams, Noopept
    • 02:05:15 Transcranial Magnetic Stimulation; Combining Technology & Pharmacology
    • 02:09:14 Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids
    • 02:14:30 Synthesis/Summary
    • 02:16:10 Support for Podcast & Research, Supplement Resources

    Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging | Episode 36 Sep 06, 2021

    In this episode, I discuss what drives hunger and satiety, and the role our brain, stomach, fat and hormones play in regulating hunger and turning off the desire to eat more. I also address how protein is assimilated better early in the day than it is later in the day, and why those using intermittent fasting might want to shift their feeding window to earlier in the day.

    Then I delve into the topic of disorders of eating: Anorexia Nervosa, where people starve themselves and Bulimia Nervosa where people binge and purge their food. I discuss some common myths about Anorexia such as the role of media images increasing the rates of anorexia and the myth of the "perfectionist" anorexic. I also review the symptoms, and the brain and chemical systems disrupted in this condition. I explain how anorexics become hyperaware of the fat content of foods and develop reflexive habits of fat-hyperawareness. Then I discuss the most effective treatments ranging from family-based models to those that target the habitual nature of low-fat/calorie food choices. I also discuss new more experimental clinical trials on MDMA, Psilocybin and Ibogaine for Anorexia, and both their promise and risks

    I review the latest work on binge eating disorder and brain stimulation, drug treatments and thyroid disruption in Bulimia and why the treatments for Bulimia are so similar to those for ADHD. Finally, I discuss "cheat days," body dysmorphia and the growing list of novel forms of eating disorders start to finish. As always, science and science-based tools are discussed.

    Thank you to our sponsors:

    • Belcampo - https://www.belcampo.com/huberman -- code "huberman"
    • Headspace - https://www.headspace.com/specialoffer
    • Athletic Greens - https://www.athleticgreens.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Links:

    • Ingesting Protein in the Morning Supports Muscle Maintenance & Growth:
    • https://bit.ly/3DPlms7
    • Studies Using Virtual Reality to Explore Eating & Hunger & Body Image:
    • https://bit.ly/3BGaDya
    • https://bit.ly/2WWGRq8

    Timestamps:

    • 00:00:00 Introduction: Fasting, & Defining Healthy Eating
    • 00:08:55 Morning Protein Is Important
    • 00:22:04 Sponsors
    • 00:26:29 Defining & Diagnosing Eating Disorders
    • 00:29:00 Anorexia Nervosa (Overview & Myths)
    • 00:33:44 Bulimia (Overview & Myths)
    • 00:37:35 Binge Eating Disorders, EDNOS, OSFEDS, Pica
    • 00:39:44 What is Hunger? What is Satiety?
    • 00:42:00 Neuronal & Hormonal “Accelerators & Brakes” on Eating
    • 00:46:17 Fat, Leptin & Fertility & Metabolic Dysfunctions in Obesity
    • 00:50:30 Why We Overeat
    • 00:55:30 Homeostasis & Reward Systems/Decisions
    • 00:59:58 Anorexia
    • 01:04:28 The Cholesterol Paradox
    • 01:06:13 Psychological vs. Biological/Genetic Factors in Anorexia
    • 01:09:44 Chemical Imbalances, Serotonergic Treatments
    • 01:12:56 Altered Habits & Rewards in Anorexia: Hyperacuity for Fat Content
    • 01:18:28 Brain Areas for Reward Based Decision Making vs. Habits
    • 01:24:06 Habit-Reward Circuits Are Flipped in Anorexics: Reward for Deprivation
    • 01:28:30 How Do You Break a Habit?
    • 01:33:23 Family Based Models, Cognitive Behavioral Therapy
    • 01:35:39 MDMA, Psilocybin, Clinical Trials, Ibogaine
    • 01:40:35 Anabolic vs. Catabolic Exercise, Spontaneous Movements, NEAT
    • 01:43:23 Distorted Self Image in Anorexia
    • 01:47:54 Bulimia & Binge-Eating, “Cheat Days”, Thyroid Hormone
    • 01:53:05 Inhibitory Control, Impulsivity, Adderall, Wellbutrin
    • 01:58:00 Direct Brain Stimulation: Nucleus Accumbens
    • 02:04:28 Anorexia/Reward. vs Bulimia/Binging
    • 02:05:45 Healthy Eating Revisited
    • 02:10:55 Synthesis, Body Dysmorphias
    • 02:14:15 Support: Podcast, & Research Studies

    Dr. Robert Sapolsky: Science of Stress, Testosterone & Free Will | Episode 35 Aug 30, 2021

    In this episode, I interview Dr. Robert Sapolsky, Ph.D., Professor of Biology, Neurology & Neurosurgery at Stanford University. We discuss stress, what defines short-term versus long-term stress, and how stress can be beneficial or detrimental, depending on the context. We also discuss stress mitigation and how our sense of control over stress mitigation techniques, including exercise, determine health outcomes. Dr. Sapolsky explains some of the key effects of the hormone testosterone — how it can amplify pre-existing tendencies for aggression or sexual behavior, but that it does not produce those behaviors per se. He also explains how testosterone impacts our social hierarchies, sense of confidence, and willingness to embrace challenges of different kinds. He also explains how our behaviors and perceptions shape testosterone levels. And we discuss estrogen and the powerful role it plays in brain development, health and longevity. Finally, we discuss free will, what it means to have free will, and if we have any free will, including how knowledge alone might allow us to make better decisions for ourselves and society.

    Thank you to our sponsors:

    • ROKA - https://roka.com - use code "huberman"
    • InsideTracker - https://insidetracker.com/huberman
    • Belcampo - https://belcampo.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Join Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Dr. Sapolsky's most recent book, "Behave: The Biology of Humans At Our Best & Worst": https://amzn.to/3yrZ6k7
    • Support Research in the Huberman Lab at Stanford on Stress, Sleep & Human Performance: https://hubermanlab.stanford.edu/giving

    Timestamps:

    • 00:00:00 Introduction: Dr. Robert Sapolsky
    • 00:02:26 Sponsors: Roka, Inside Tracker, Belcampo
    • 00:06:30 Stress: Short & Long-Term, Good & Bad
    • 00:09:11 Valence & Amygdala
    • 00:11:00 Testosterone: Common Myths vs. Actual Truths
    • 00:15:15 Behaviors that Affect Testosterone
    • 00:17:20 Mindsets & Contexts that Affect Testosterone
    • 00:20:28 How Finger Length Ratios Reflect Prenatal Hormone Levels
    • 00:22:30 Aggression: Male-Female, Female-Male, & Female-Female
    • 00:24:05 Testosterone: The Challenge Hypothesis
    • 00:29:20 How Dopamine Impacts Testosterone & Motivation
    • 00:32:32 Estrogen: Improves Brain & Longevity BUT TIMING IS KEY
    • 00:39:40 Are Testosterone & Sperm Counts in Males Really Dropping?
    • 00:42:15 Stress Mitigation & Our Sense of Control
    • 00:51:35 How Best to Buffer Stress
    • 00:57:04 Power of Perception, Choice & Individual Differences
    • 01:00:32 Context-Setting, Prefrontal Cortex & Hierarchy
    • 01:11:20 How Dr. Sapolsky Accomplishes Deep Thinking
    • 01:13:17 Do We Have Free Will?
    • 01:20:50 How to Apply Knowledge & Learning
    • 01:23:44 Robert’s New Book: “Determined: The Science of Life Without Free Will”
    • 01:28:27 Reflections, Support of Podcast, & Supporting Stress Research

    Understanding & Conquering Depression | Episode 34 Aug 23, 2021

    This episode, I explain what major depression is at the biological and psychological level and the various treatments that peer-reviewed studies have revealed can help prevent and treat depression. I explain the three major chemical systems that are altered in depression: norepinephrine, serotonin and dopamine. I discuss genetic predispositions to depression and how stress, thyroid hormone and cortisol play a role in many forms of depression. I also discuss inflammation as a common feature of many depression symptoms. I review 8 specific science-supported protocols for treating and avoiding depression, including EPA fatty acids (which have been shown to rival certain prescription treatments), how exercise protects against depression, studies of creatine, adjusting dopamine balance and more. I also discuss the results of ongoing clinical trials for ketamine and psilocybin for depression, how these compounds work and finally, I review how ketogenic diets can help in certain cases of depression, especially treatment-resistant major depression.

    Thank you to our sponsors:

    • InsideTracker - https://www.insidetracker.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman
    • Belcampo - https://www.belcampo.com/huberman -- code "huberman"

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Join Newsletter - https://hubermanlab.com/neural-network

    Links:

    • Review of EPAs for the Treatment of Depression - https://bit.ly/2Wl15ti
    • Review of Creatine for the Treatment of Depression - https://www.mdpi.com/520864
    • Recent Study on the Clinical Use of Psilocybin for Treatment of Depression - https://bit.ly/3sFSGMM

    Timestamps:

    • 00:00:00 Mood Disorders & Maintaining Mental Health (Protocol 1)
    • 00:07:10 Sponsors
    • 00:11:15 Major Depression
    • 00:18:40 “Anti-Self” Confabulation
    • 00:21:42 Autonomic (Vegetative) Symptoms of Depression
    • 00:26:58 Norepinephrine, Dopamine & Serotonin
    • 00:31:50 SSRIs (Prozac, Zoloft, etc.): Selective Serotonin Reuptake Inhibitors
    • 00:37:00 Epinephrine/Motor Functions, Dopamine/Motivation & Craving, Serotonin/Emotions
    • 00:39:33 Physical & Emotional Pain are Linked: Substance P
    • 00:41:50 Hormones & Depression: Thyroid & Cortisol
    • 00:46:50 Genetic Susceptibility to Depression: Impact of Stress
    • 00:50:50 Understanding Biological Mechanism Is Key: Recipes versus Skills
    • 00:52:50 Tools for Dealing with Depression: Logic & Implementation (Protocol 2)
    • 00:56:25 Brain Inflammation & Mental State: Cytokines, Prostaglandins, etc.
    • 00:59:20 Protocol 3: Essential Fatty Acids (Omega-3, EPAs: Eicosapentaenoic Acid)*
    • 01:02:50 How EPAs Help Offset Depression: Serotonin Synthesis, Kynurenine, Quinolinic Acid
    • 01:05:25 Protocol 4: How Exercise Offsets Depression
    • 01:11:44 Protocol 5: Creatine Monohydrate, Forebrain Function & NMDA receptors*
    • 01:20:30 Protocol 6*: Ketamine, PCP (*Prescription-Only), & NMDA-Receptor Function
    • 01:33:08 Protocol 7*: Psychedelics (*In Clinical Trials) for Major Depression: Psilocybin*
    • 01:47:00 Protocol 8: Ketogenic Diet, GABA (Gamma-Aminobutyric Acid)
    • 01:54:50 Summary of Protocols Covered
    • 02:00:10 Support & Additional Resources

    Dr. Anna Lembke: Understanding & Treating Addiction | Episode 33 Aug 16, 2021

    This episode I interview Dr. Anna Lembke, MD, Chief of the Stanford Addiction Medicine Dual Diagnosis Clinic at Stanford University School of Medicine. Dr. Lembke is a psychiatrist expert in treating addictions of all kinds: drugs, alcohol, food, sex, video games, gambling, food, medication, etc. Dr. Lembke is also an expert in the opioid crisis, and the author of Dopamine Nation: Finding Balance in the Age of Indulgence (https://amzn.to/3AHHGBp).

    We discuss the biology and psychology of why people become addicted to certain substances and behaviors and the key role that our "dopamine balance" plays in creating addiction. We also discuss the science and practice of how to conquer addictions, why people relapse and how to avoid relapsing. Dr. Lembke also shares her expertise on topics closely related to addiction such as community, shame and lying and she explains why telling the truth—even about the most basic things in daily life, adjusts dopamine levels in our brain.

    This episode is an important one for anyone struggling with addictions of any kind, for their friends and families and for health care professionals. It is also for anyone who has defeated addiction and is determined to stay clean. Last but not least, it helps explain why all humans do what we do, and how we can all maintain a healthy sense of pleasure seeking in life.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Join the Neural Network - https://hubermanlab.com/neural-network

    Dr. Anna Lembke Links:

    • Website: https://bit.ly/3iPtGje
    • Stanford Profile: https://stanford.io/3AI9SEu
    • Dopamine Nation (new book): https://amzn.to/3AHHGBp

    Timestamps:

    • 00:00:00 Dr. Anna Lembke, Addiction Expert
    • 00:02:25 Disclaimer & Sponsors: Roka, InsideTracker, Headspace
    • 00:07:00 Dopamine, Happiness & Impulsivity
    • 00:15:56 What Is Pleasure?
    • 00:18:20 Addiction, Boredom & Passion for Life
    • 00:24:00 Pain-Pleasure Balance Controls Addiction
    • 00:29:10 Dopamine Deficits, Anhedonia
    • 00:30:47 Are All Addictions the Same?
    • 00:35:38 Boredom & Anxiety Lead to Creativity
    • 00:40:35 Finding Your Passion Starts with Boredom & Action Steps
    • 00:50:05 How to Break an Addiction
    • 00:55:25 Relapse, Craving & Triggers
    • 01:07:40 Can People Get Addicted To “Sobriety”?
    • 01:11:45 Are We All Wired for Addiction?
    • 01:15:57 Bizarre Addiction
    • 01:18:14 Recovered Addicts Are Heroes
    • 01:20:10 Lying, Truth Telling, Guilt & Shame
    • 01:30:40 Clinical Applications of: Ibogaine, Ayahuasca, Psilocybin & MDMA
    • 01:40:20 Social Media Addiction
    • 01:51:25 Narcissism
    • 01:53:30 Goal Seeking, Success & Surprise
    • 01:58:10 Reciprocity
    • 02:01:15 Closing Comments, Resources

    How to Control Your Sense of Pain & Pleasure | Episode 32 Aug 09, 2021

    This episode I discuss our sense of pain and pleasure: where and how they each arise in our mind and body and various ways to control their intensity. I discuss the science of behavioral tools like acupuncture and hypnosis and directed pressure, including the neural circuits they each activate to modulate our experience of pain or pleasure. I also discuss whole body pain, pain "syndromes" and novel pain relief compounds such as Acetyl-L-Carnitine, SAMe and Agmatine. I discuss neuroplasticity of the pain system and the key role that visual perception plays in pain modulation. Finally, I address the link between dopamine, serotonin, and oxytocin, with arousal, pleasure and pain. As always, both basic science and various protocols are described.

    Note: The description of the dorsal root ganglia (DRGs) was intentionally simplified and does not include mention of dorsal horn spinal relay neurons, etc. For an excellent full text review of this anatomy and circuits for touch sensing, please see: https://bit.ly/3jH9CPf

    Thank you to our sponsors:

    • InsideTracker - https://www.insidetracker.com/huberman
    • Helix Sleep - https://www.helixsleep.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Join the Neural Network - https://hubermanlab.com/neural-network

    Links:

    • Instagram discussion with Dr. Sean Mackey, MD, PhD - https://www.instagram.com/p/CMVq0X8Bk1D/
    • Agmatine study - https://bit.ly/3CtTwRn
    • Mechanistic basis of acupuncture - https://bit.ly/2VHi0pz

    Timestamps:

    • 00:00:00 Skin, Pain, Pleasure
    • 00:01:50 Protocol 1: Maximizing Motivation (with Dopamine & Pleasure)
    • 00:07:12 Sponsors: InsideTracker, Helix Sleep, Athletic Greens
    • 00:12:04 Pleasure & Pain, & Skin Sensors
    • 00:18:13 Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals
    • 00:22:16 Two-Point Discrimination, Dermatomes
    • 00:28:11 Thoughts & Genes That Make Physical Pain Worse
    • 00:33:45 Expectations, Anxiety, & Pain Threshold
    • 00:40:27 Protocol 2: Cold Sensing Is Relative; Getting Into Cold Water
    • 00:45:22 Protocol 3: Heat Is Absolute
    • 00:48:10 Injury & Pain
    • 00:52:04 Protocol 4: Plasticity of Pain: Key Role of Vision
    • 00:58:08 Sensing Disparate Body Parts As Merged
    • 01:01:00 Pain “Syndromes”, Psychogenic Fever, “Psychosomatics”
    • 01:04:40 Fibromyalgia, Naltrexone, Protocol 5: Acetyl-L-Carnitine
    • 01:12:24 Protocol 6: Agmatine, S-adenosyl-L-methionine (SAMe), L-5-Methyltetrahydrofolate*
    • 01:17:27 Acupuncture: Mechanism, Non-Responders, Itch & Inflammation
    • 01:28:20 Laser Photobiomodulation, Protocol 7: Hypnosis (reveri.com)
    • 01:30:00 Protocol 8: Pressure-Based Pain Relief, “Gate Theory of Pain (Relief)”
    • 01:37:53 Redheads & Pain Thresholds, Endogenous Opioids
    • 01:44:02 Protocol 8: Love & Pain, Dopamine
    • 01:49:23 Pleasure & Reproduction, Dopamine & Serotonin, Oxytocin
    • 01:51:40 Protocol 9: PEA, L-Phenylalanine (Precursor to Tyrosine)
    • 01:55:40 Contextual Control of Pleasure by Autonomic Arousal, Dopamine Baselines
    • 01:59:40 Pleasure-Pain Balance
    • 02:01:24 Protocol 10: Controlling Pleasure, Dopamine & Motivation Over Time
    • 02:06:40 Protocol 11: Immediate, Non-Goal-Directed Pleasure, PAG
    • 02:08:40 Direction of Touch: Pleasure Versus Pain, Arousal & Touch “Sensitivity”
    • 02:13:00 Synthesis & How to Conceptualize Pain and Pleasure, Support

    Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep | Episode 31 Aug 02, 2021

    In this episode, my guest is Dr. Matt Walker, Professor of Neuroscience and Psychology and the Founder & Director of the Center for Human Sleep Science at the University of California, Berkeley. He is also the author of the international best-selling book Why We Sleep and the host of "The Matt Walker Podcast." We discuss the biology of sleep, including its various stages and what specifically happens to those stages when we don't get enough sleep. We also discuss the effects of sunlight, caffeine, alcohol, naps, hormones, exercise, marijuana, sexual activity, and various supplements on sleep. The episode consists of both basic science information and many science-supported actionable tools.

    Dr. Matthew Walker:

    • Podcast - https://www.sleepdiplomat.com/podcast
    • Twitter - https://twitter.com/sleepdiplomat
    • Instagram - https://instagram.com/drmattwalker
    • Website - https://www.sleepdiplomat.com

    Thank you to our sponsors:

    • ROKA - https://www.roka.com -- code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Belcampo - https://www.belcampo.com/huberman -- code: huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Neural Network - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Introducing Dr. Matt Walker
    • 00:02:00 Sponsors: Roka, InsideTracker, Belcampo
    • 00:06:00 What Is Sleep?
    • 00:10:20 REM (Rapid Eye Movement) aka 'Paradoxical Sleep'
    • 00:16:15 Slow Wave Sleep aka 'Deep Sleep'
    • 00:24:00 Compensating For Lost Sleep
    • 00:32:20 Waking in the Middle Of The Night
    • 00:39:48 Uberman (Not Huberman!) Sleep Schedule
    • 00:42:48 Viewing Morning SUNLight
    • 00:49:20 Caffeine
    • 01:07:54 Alcohol
    • 01:14:30 Growth Hormone & Testosterone
    • 01:16:14 Emotions, Mental Health & Longevity
    • 01:20:40 Books vs. Podcasts
    • 01:21:20 Lunchtime Alcohol
    • 01:25:00 Marijuana/CBD
    • 01:36:00 Melatonin
    • 01:54:14 Magnesium
    • 01:58:10 Valerian, Kiwi, Tart Cherry, Apigenin
    • 02:15:00 Tryptophan & Serotonin
    • 02:19:24 Naps & Non-Sleep-Deep-Rest (NSDR)
    • 02:28:23 Is It Possible To Get Too Much Sleep?
    • 02:34:35 Sex, Orgasm, Masturbation, Oxytocin, Relationships
    • 02:47:30 Unconventional Yet Powerful Sleep Tips
    • 02:59:10 Connecting to & Learning More from Dr. Walker
    • 03:04:42 The New Dr. Matt Walker Podcast, Reviews & Support

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    How to Optimize Your Brain-Body Function & Health | Episode 30 Jul 26, 2021

    This episode I describe how the organs of the body influence the function and health of our brain and how our brain controls our bodily organs. The conscious awareness of this brain-body dialogue is called interoception. I describe how two factors- mechanical forces (e.g., pressure, pain, volume, etc.) and chemical factors (e.g., gut acidity, microbiome diversity, etc.) combine to influence our moods, control inflammation, immune system, recovery from injury and more. I explain how specific actions of our lungs, heart, spleen, and diaphragm, control our brain via the vagus nerve and other neural pathways. I describe 11 science-supported protocols for enhancing brain-body health and the logic behind them.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Join the Neural Network - https://hubermanlab.com/neural-network

    Links:

    • Sonnenburg, Cell Press Study - https://bit.ly/SonnenburgCellPress

    Timestamps:

    • 00:00:00 Your Sense of Self: Interoception
    • 00:01:25 Protocol 1: Fermented Foods, Not Fiber, to Reduce Inflammation
    • 00:03:30 Attributions
    • 00:08:22 Main Drivers of Feelings & Performance
    • 00:11:45 Brain-Body: A Mechanical & Chemical Dialogue
    • 00:17:50 LDB (Lung-Diaphragm-Brain) Dialogue
    • 00:21:00 Protocols 2, 3, 4: Control Heart Rate With Breathing
    • 00:29:08 Sensing Lung Pressure: Piezo Receptors
    • 00:30:54 Carbon Dioxide, From Air to Blood
    • 00:34:02 Protocol 5: Alert While Calm
    • 00:40:50 Baroreceptors: Hering-Breuer Reflex
    • 00:42:47 Gut Volume & The Desire to Open Your Mouth
    • 00:48:18 Protocol 6: Enhancing Gut-To-Brain Communication, Fasting
    • 00:51:50 Intestines, Fatty Acids, Amino Acids & Sugar
    • 00:57:00 Protocol 7: Reducing Sugar Cravings with Specific Amino Acid Nutrients
    • 00:58:58 Gut Acidity (Is Good)
    • 01:02:20: Improving Nasal Microbiome
    • 01:04:13 Inflammation & Microbiome: Fiber vs. Fermented
    • 01:11:15 Protocol 8: Reducing Inflammation & Enhancing Brain Function w/Fermented Foods
    • 01:13:10 Leaking Guts, Auto-Immune function & Glutamine
    • 01:15:50 Gut Acidity: HCl (hydrochloric acid), Pepsin
    • 01:18:30 Probiotics & Brain Fog
    • 01:21:45 Nausea: Happens in Your Brain; Area Postrema
    • 01:28:25 Protocol 9: Reducing Nausea: Ginger, Peppermint, CBD, etc.
    • 01:30:40 Fever: Triggers and Control Knobs: OVLT
    • 01:37:00 Protocol 10: Cooling the Blood Properly
    • 01:38:53 Sensing Feelings, Vagus Nerve, Stress
    • 01:41:50 Mental Emotions Reflect Bodily Conditions
    • 01:45:00 Sensing Other People’s Emotions via the Body
    • 01:46:00 Protocol 11: Increasing Interoception, Sensing Heartbeat
    • 01:50:40 Conclusions & Resources

    Dr. Lex Fridman: Machines, Creativity & Love | Episode 29 Jul 19, 2021

    Dr. Lex Fridman PhD, is a scientist at MIT (Massachusetts Institute of Technology), working on robotics, artificial intelligence, autonomous vehicles and human-robot interactions. He is also the host of the Lex Fridman Podcast where he holds conversations with academics, entrepreneurs, athletes and creatives. Here we discuss humans, robots, and the capacity they hold for friendship and love. Dr. Fridman also shares with us his unique dream for a world where robots guide humans to be the best versions of themselves, and his efforts to make that dream a reality.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman

    Connect with Dr. Lex Fridman:

    • Instagram - https://instagram.com/lexfridman/
    • Twitter - https://twitter.com/lexfridman
    • Facebook - https://www.facebook.com/lexfridman/
    • YouTube - https://www.youtube.com/lexfridman
    • Podcast - https://lexfridman.com/podcast/

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • https://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Join the Neural Network - https://hubermanlab.com/neural-network

    Links:

    • Hedgehog and the Fog - https://www.youtube.com/watch?v=ThmaGMgWRlY

    Timestamps:

    • 00:00:00 Introduction: Lex Fridman
    • 00:07:35 What is Artificial Intelligence?
    • 00:26:46 Machine & Human Learning
    • 00:32:21 Curiosity
    • 00:36:55 Story Telling Robots
    • 00:40:48 What Defines a Robot?
    • 00:44:30 Magic & Surprise
    • 00:47:37 How Robots Change Us
    • 00:49:35 Relationships Defined
    • 01:02:29 Lex’s Dream for Humanity
    • 01:11:33 Improving Social Media
    • 01:16:57 Challenges of Creativity
    • 01:21:49 Suits & Dresses
    • 01:22:22 Loneliness
    • 01:30:09 Empathy
    • 01:35:12 Power Dynamics In Relationships
    • 01:39:11 Robot Rights
    • 01:40:20 Dogs: Homer & Costello
    • 01:52:41 Friendship
    • 01:59:47 Russians & Suffering
    • 02:05:38 Public vs. Private Life
    • 02:14:04 How To Treat a Robot
    • 02:17:12 The Value of Friendship
    • 02:20:33 Martial Arts
    • 02:31:34 Body-Mind Interactions
    • 02:33:22 Romantic Love
    • 02:42:51 The Lex Fridman Podcast
    • 02:55:54 The Hedgehog
    • 03:01:17 Concluding Statements

    Maximizing Productivity, Physical & Mental Health with Daily Tools | Episode 28 Jul 12, 2021

    In this episode, I discuss science-supported tools for enhancing focus, learning, creativity, sleep, physical strength and endurance and brain and body health. I explain each protocol in detail, the rationale behind it, and how the protocol can be adjusted depending on individual needs. I set these tools in the context of a 24-hour day as a way of framing how one might incorporate these tools and protocols into their own daily routine.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.helixsleep.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Neural Network - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Introduction: Protocols for sleep, mood, focus, exercise creativity
    • 00:04:08 Sponsors
    • 00:08:50 Protocol 1: Record Your Daily Waking Time & Temperature Minimum
    • 00:12:07 Protocol 2: Self-Generate Forward Motion (Outdoors)
    • 00:17:00 Protocol 3: View Natural Light For 10-30min Every Morning
    • 00:22:43 What To Do If You Can’t View The Sun: Blue Light
    • 00:26:50 Protocol 4: Hydrate Correctly
    • 00:28:00 Protocol 5: Delay Caffeine 90-120m After Waking
    • 00:30:48 Protocol 6: Fast (or Fat-Fast) Until Noon
    • 00:32:30 What Actually Breaks A Fast & What Doesn’t?
    • 00:34:30 Fat Loss & Glucagon-Like Peptide 1 (GLP1), Yerba Mate, Guayusa Tea
    • 00:37:30 Protocol 7: Optimize Deep Work: Visual Elevation, Ultradian Cycles, White Noise
    • 00:48:30 Optimal Time of Day To Do Hard Mental Work
    • 00:52:07 Protocol 8: Optimal Exercise; 3:2 Ratio
    • 01:03:54 Tools for Training & Mental Focus: Fasting, Salt, Stimulants, Alpha-GPC
    • 01:10:00 Protocol 9: Eat For Brain Function & Mood
    • 01:17:39 Protocol 10: Get Your Testosterone & Estrogen In An Ideal Range
    • 01:24:00 Protocol 11: Reset the Mind & Body, Enhance Neuroplasticity, Reveri.com
    • 01:31:15 Protocol 12: Hydrate Correctly, Nap Rules
    • 01:33:29 Protocol 13: View Late Afternoon/Evening Light To Support Sleep & Dopamine
    • 01:39:00 Protocol 14: Eat Dinner That Promotes Serotonin, Calm Sleep
    • 01:44:27 Protocol 15: Optimize Falling & Staying Asleep; Tools & Supplements That Work
    • 01:55:00 Protocol 16: Preventing Middle of the Night Waking
    • 01:59:10 Protocol 17: Weekends, Recovering From A Poor Nights Sleep
    • 02:05:20 Neural Network, Supplement Sources, Sponsors

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com


    The Science of Hearing, Balance & Accelerated Learning | Episode 27 Jul 05, 2021

    This episode I describe how our ears and nervous system decode sound waves and gravity to allow us to hear and make sense of sounds. I also describe protocols for rapid learning of sound and other types of information. I discuss sound localization, doppler effects (sound motion), pitch perception and how we isolate sounds in noisy environments. I also review the scientific findings on binaural beats and white noise and how they can improve learning. Other topics and protocols include tinnitus, sea sickness, ear movement, ear growth and the science-supported ways we can all accelerate learning using "gap effects".

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Headspace - https://www.headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Neural Network - https://hubermanlab.com/neural-network

    Links:

    • Review on spacing effects and learning: https://bit.ly/3qM6bto
    • Micro-rest and accelerated learning: https://bit.ly/3hitXKM
    • Ear movement: https://bit.ly/2TrS9Bf
    • Ears making sounds, hormones: https://bit.ly/3yneKgV
    • Binaural beats: review and references: https://bit.ly/36fggFO

    Timestamps:

    • 00:00:00 Overview of Topics
    • 00:02:20 Protocol: New Data for Rapid Learning
    • 00:09:10 Introduction: Hearing & Balance
    • 00:13:53 How We Perceive Sounds
    • 00:21:56 Your Hearing Brain (Areas)
    • 00:23:48 Localizing Sounds
    • 00:28:00 Ear Movement: What It Means
    • 00:33:00 Your Ears (Likely) Make Sounds: Role of Hormones, Sexual Orientation
    • 00:35:30 Binaural Beats: Do They Work?
    • 00:43:54 White Noise Can Enhance Learning & Dopamine
    • 00:51:00 Headphones
    • 00:55:51 White Noise During Development: Possibly Harmful
    • 01:03:25 Remembering Information, & The Cocktail Party Effect
    • 01:12:55 How to Learn Information You Hear
    • 01:18:10 Doppler
    • 01:22:43 Tinnitus: What Has Been Found To Help?
    • 01:30:40 Aging: How Big Are Your Ears?
    • 01:35:00 Balance: Semi-Circular Canals
    • 01:40:35 A Vestibular Experiment
    • 01:43:15 Improve Your Sense of Balance
    • 01:48:55 Accelerating Balance
    • 01:51:55 Self-Generated Forward Motion
    • 01:56:25 Dizzy versus Light-Headed
    • 01:58:38 Motion Sickness Solution
    • 02:01:23 Synthesis

    Dr. Karl Deisseroth: Understanding & Healing the Mind | Episode 26 Jun 28, 2021

    Dr. Karl Deisseroth, MD, PhD, is a Clinical Psychiatrist and scientist who directs a bioengineering research laboratory at Stanford University School of Medicine. His work aims to understand and develop treatments for disorders of the mind such as depression, attention deficit disorders (ADHD & ADD), autism, schizophrenia, anxiety, eating disorders, borderline personality and obsessive-compulsive disorder. We discuss his experience treating his patients and his laboratory’s mission to find and develop cures for mental disease and tools for probing how the brain works.

    Dr. Karl Deisseroth:

    • Twitter: https://twitter.com/KarlDeisseroth
    • New book: https://amzn.to/3diiKHG
    • Lab Website: https://web.stanford.edu/group/dlab

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • https://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Neural Network - https://hubermanlab.com/neural-network

    Timestamps:

    • 00:00:00 Introduction
    • 00:07:41 Using Language to Understand the Mind
    • 00:12:19 Blood Tests For Mental Disease
    • 00:13:38 The Largest Challenges Facing Treatment of Mental Health
    • 00:20:21 Predicting Depression & Suicide
    • 00:22:47 Drugs That Work for Brain Illness
    • 00:27:01 What Would A Cure For the Broken Mind Look Like?
    • 00:32:23 Channelopsins: Tools For Understanding & Treating the Mind
    • 00:39:10 Curing Blindness with Channelopsins
    • 00:41:58 Why Karl Became a Scientist
    • 00:47:10 Vagus Nerve In Depression
    • 00:54:12 Challenges To Overcome for Treating Mental Illness with Channelopsins
    • 00:58:34 Using the Dialogue with Patients to Guide Treatment
    • 01:00:52 How Our Eyes Reveal Our Mental Health
    • 01:06:04 Controlling Structures Deep In the Brain
    • 01:08:23 The Most Effective Drugs Often Have the Most Side Effects
    • 01:09:50 Do Psychiatrists Take the Drugs They Prescribe
    • 01:14:15 Moving From Experimental Tools To Novel Treatments
    • 01:16:00 Brain-Machine Interfaces & Neuralink
    • 01:19:30 ADHD & Dr. Deissroth’s Approach To Focusing His Mind
    • 01:26:36 How Dr. Deisseroth Balances A Career In Medicine, Science & Family
    • 01:35:41 New Ways of Exploring Brains: CLARITY
    • 01:38:49 What Is Special About the Human Brain?
    • 01:46:03 Psychedelics
    • 01:54:12 MDMA
    • 01:57:15 Dr. Deisseroth’s New Book “Projections: A Story of Emotions”
    • 01:59:42 Connecting with Dr. Deisseroth on Twitter

    How Smell, Taste & Pheromone-Like Chemicals Control You | Episode 25 Jun 21, 2021

    This episode explains how we sense chemicals through smell, taste, and pheromones. How things smell and taste and chemicals in the tears, breath, and on the skin of others have a profound effect on how we feel, what we do, and our hormones. I explain the 3 types of responses to smell, the 5 types of tastes, the possible existence of sixth taste sense, and how the act of sniffing can make us learn and focus better. I explain how smell and taste reflect brain health and can assess and even promote brain regeneration. I discuss how eating specific categories of foods makes us crave more of those foods, including how to make sour things taste sweet and develop a heightened sense of smell and taste.

    Sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker
    • Athletic Greens

    Timestamps:

    • 00:00:00 Intro
    • 00:06:02 Sensing Chemicals: Smell, Taste and Chemicals That People Make To Control Each Other
    • 00:09:10 Vision Protocols Recap (Brief): Near-Far Viewing and 2 hours/day outside, and Correction
    • 00:12:20 Color Vision: Excellent Resource: What is Color? (The Book)
    • 00:13:54 How We Sense Chemicals: Enter Our Nose, Mouth, Eyes, Skin
    • 00:17:28 The Chemicals From Other People’s Tears Lower Testosterone and Libido
    • 00:21:16 SMELL: Sniffing, A Piece of Your Brain In Your Nose, 3 Responses To Smells
    • 00:24:40 Smells and Memory: Why They Are So Powerfully Associated
    • 00:26:40 Pheromone Effects: Spontaneous Miscarriage, Males and Timing Female Puberty
    • 00:28:56 Sniffing Creates Alertness and If Done Properly Can Help You Focus and Learn Better
    • 00:34:00 Protocol 1: Sniffing (Nothing) 10-15X Enhances Your Ability to Smell and Taste
    • 00:35:50 Smelling Salts, Ammonia and Adrenaline
    • 00:38:25 How You Can Become A Human Scent Hound, Detecting Cancer, and Tasting Better
    • 00:43:45 Smell As A Readout Of Brain Health and Longevity; Regaining Lost Sense Of Smell
    • 00:48:30 Dopamine, Sense Of Smell, New Neurons and New Relationships
    • 00:50:20 Why Brain Injury Causes Loss Of Smell; Using Smell To Gauge and Speed Recovery
    • 00:53:33 Using Smell To Immediately Becoming Physically Stronger
    • 00:54:40 Smelling In Our Dreams, Active Sniffing In Sleep, Sniffing As a Sign Of Consciousness
    • 00:57:35 Mint Scents Create Alertness By Activating Broad Wake-Up Pathways Of Your Nervous
    • 00:59:48 Protocol 2 Pleasant Or Putrid: The Microwave Popcorn Test, Cilantro, Asparagus, Musk
    • 01:03:00 Skunks, Costello, All Quiet On The Western Front
    • 01:04:32 TASTE: Sweet, Salty, Bitter, Umami, Sour; Your Tongue, Gustatory Nerve, NST, Cortex
    • 01:08:45 Energy, Electrolytes, Poisons, Gagging, Amino Acid and Fatty Acid Sensing, Fermentation
    • 01:13:48 Our 6th Sense of Taste: FAT Sensing
    • 01:15:05 Gut-Brain: Your Mouth As An Extension Of Your Gut; Burned Mouth and Regeneration
    • 01:19:30 Protocol 3: Learn To Be A Super-Taster By Top-Down Behavioral Plasticity
    • 01:22:20 The Umami-Sweet Distinction: Tigers Versus Pandas. Aggression Versus Passivity
    • 01:25:05 Eating More Plants Versus Eating More Meat, Cravings and Desire
    • 01:27:15 Food That Makes You Feel Good Or Bad: Taste Receptors On Our Testes Or Ovaries
    • 01:30:05 Biological Basis For The Sensuality of Umami and Sweet Foods
    • 01:32:28 Appetitive and Aversive Sensing: Touching Certain Surfaces, Tasting Certain Foods
    • 01:33:35 Amino Acids Are Key To Life, The Maillard Reaction, Smell-Taste Merge, Food Texture
    • 01:39:00 How Processed Food Make You Crave More Processed Foods
    • 01:39:44 Protocol 4: Invert Your Sense of Sweet and Sour: Miracle Fruit; Swapping Bitter and Sweet
    • 01:43:03 Pheromones, Desire To Continue Mating: Coolidge Effect Occurs In Males and Females
    • 01:46:40 Do Women Influence Each Others Menstrual Cycles?
    • 01:49:19 Recognizing the Smell Of Your Romantic Partner
    • 01:50:30 Differences In Odor Detection Ability, Effects Of Hormones
    • 01:53:00 We Rub The Chemicals Of Others On Our Eyes and Skin, Bunting Behavior
    • 01:56:40 Summary

    The Science of Vision, Eye Health & Seeing Better | Episode 24 Jun 14, 2021

    This episode I describe how we see, meaning how our eyes focus, convert light information into electricity the rest of the brain can understand and how our brain creates the incredible thing we experience as “sight”. I also describe how we can train and support our visual system to improve at any age. I describe more than a dozen protocols to support depth perception, offset near-sightedness, improve mood, sleep, and our ability to focus (both visual focus and our mental focus generally). I also explain how to use eyesight to improve our levels of alertness and why visual hallucinations, lazy eyes and colorblindness occur. I also describe various compounds that may assist in supporting visual health and possibly improve our vision. Many simple, zero-cost protocols and a lot of scientific mechanisms are covered in this episode in clear language anyone can understand-- it is for anyone that values their brain and whether eyesight, young, adult-age or advanced age.

    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Helix Sleep - https://www.helixsleep.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website: https://hubermanlab.com
    • Join the Neural Network: https://hubermanlab.com/neural-network

    Link to eye exercise videos for smooth pursuit, amblyopia, etc. (Numbering of videos does correspond to numbers in episode caption.) https://www.youtube.com/c/VisualExercises/videos

    Timestamps:

    • 00:00:00 Introduction
    • 00:04:51 Protocol: Concurrent Training For Endurance, Strength, Hypertrophy
    • 00:07:24 The Senses, Vision, Seeing & What We Should All Do To See Better
    • 00:10:35 Our Eyes: What They Really Do, & How They Work
    • 00:14:30 Converting Light Into Electricity Language: Photoreceptors, Retinal Ganglion Cells
    • 00:17:00 We Don’t See Anything Directly: It Is All A Comparison Of Reflected Light
    • 00:19:35 Dogs, Cats, Snakes, Squirrels, Shrimps, Diving Birds, & You(r View Of The World)
    • 00:24:05 Everything You See Is A Best Guess, Blind Spots
    • 00:25:50 Depth Perception
    • 00:28:00 Subconscious Vision: Light, Mood, Metabolism, Dopamine; Frog’s Skin In Your Eyes
    • 00:32:00 Blue-Yellow Light, Sunlight; & Protocol 1 For Better Biology & Psychology;
    • 00:35:00 Protocol 2: Prevent & Offset Near-Sightedness (Myopia): Outdoors 2 Hours Per Day
    • 00:42:00 Improving Focus: Visual & Mental; Accommodation, Your Pupils & Your Bendy Lens
    • 00:48:50 Protocol 3: Distance Viewing For 20min For Every 90 Minutes of “Close Viewing”
    • 00:52:20 Protocol 4: Self-Generated Optic Flow; Move Yourself Through Space Daily
    • 00:54:26 Protocol 5: Be More Alert; Eyelids, Eye Size, Chin Position, Looking Up Versus Down
    • 00:59:21 Protocol 6: Sleep In A Very Dark Room To Prevent Myopia (Nearsightedness)
    • 01:02:55 Color Vision, Colorblindness, Use Magentas Not Reds,
    • 01:04:32 Protocol 7: Keeping Your Vision Sharp With Distance Viewing Every Day
    • 01:06:05 Protocol 8: Smooth Pursuit
    • 01:08:48 Protocol 9: Near-Far Visual Training 2-3 Minutes 3-4 Times a Week
    • 01:13:33 Protocol 10: Red Light, Emerging Protocol To Improve Photoreceptors & Vision
    • 01:16:20 Dry Eyes; Blinking, Protocol 11
    • 01:18:40 Lazy Eye, Binocular Vision, Amblyopia; Triggering Rapid Brain Plasticity; Protocol 12
    • 01:24:48 Protocol 12: Determine Your Dominant Eye; Near-Far Training
    • 01:27:57 Visual Hallucinations: The Consequence of An Under-Active Visual Brain
    • 01:29:47 Protocol 13: Snellen Chart: A Simple, Cost-Free Way To Test & Maintain Vision
    • 01:33:00 Vitamin A, Lutein, Idebenone, Zeaxanthine, Astaxanthin, Blood Flow
    • 01:44:20 Summary of Protocols, Vital Point About Blood & Oxygen For Vision
    • 01:46:00 Episode Length, Captions, Zero-Cost Support, Instagram, Searching Topics

    How To Build Endurance In Your Brain & Body | Episode 23 Jun 07, 2021

    In this episode, I discuss endurance: our ability to perform effort over extended amounts of time. I describe the four kinds of endurance:

    • Muscular endurance.
    • Long-duration (single-set) efforts.
    • The two kinds of high-intensity interval training that can benefit our brain and various systems of our body.

    I discuss the fuel systems they each rely on and how to build up your capillary beds in muscle and in the brain to increase oxygen utilization or improve postural endurance. I discuss efficiency of effort, maximizing quality of effort, and the simplest hydration formula. I review how our heart literally gets stronger (as a muscle) when we oxygenate muscles properly and ways to warm up with and improve respiration/breathing. I also discuss motivation for long bouts of work and the visual physiological basis of the "extra gear" we all can leverage for effort. Finally, I review how accelerating as we fatigue can allow us to access untapped energetic resources. As always, both science, mechanism and tools are discussed throughout


    Thank you to our sponsors:

    • ROKA - https://www.roka.com - code: huberman
    • InsideTracker - https://www.insidetracker.com/huberman
    • Athletic Greens - https://www.athleticgreens.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • https://www.thorne.com/u/huberman

    Mechanistic review of training adaptations

    Example protocols


    Science & Tools For Muscle Growth, Increasing Strength & Muscular Recovery | Episode 22 May 31, 2021

    In this episode I describe how our brain and nervous system control muscle tissue and how to leverage that for muscle maintenance, growth (hypertrophy) and recovery. I explain how neurons control muscle contractions and limb movements. I explain muscle metabolism and muscle fiber recruitment. I detail protocols for increasing muscular growth and for neuro-muscular recovery. I explain the effects of deliberate cold, anti-inflammatory agents, and anti-histamines on training progress. I describe science-supported protocols using certain weight load ranges, total sets per week, training intensity, frequency, and in-between set activities if one's goal is to increase muscle growth, strength or endurance. I review three foundational compounds and nutrients and three optimization compounds and nutrients that have been shown to improve neuro-muscular performance. Finally, I explain how to leverage exercise and weight training to enhance cognitive function.

    Thank you to our sponsors:

    • InsideTracker - https://insidetracker.com/huberman
    • Belcampo - https://belcampo.com/huberman
    • Headspace - https://headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    How to Lose Fat with Science-Based Tools | Episode 21 May 24, 2021

    This episode I describe the science of fat loss, including how fat is mobilized and oxidized (burned) and how to increase fat burning by leveraging the nervous system. Most people don't realize it, but our neurons connect to our fat and release epinephrine/adrenaline to facilitate fat oxidation.


    How to Learn Skills Faster | Episode 20 May 17, 2021

    This episode I discuss the science and practice of learning physical skills: what it involves at a biological level, and what to focus on during skill learning at each stage to maximize learning speed and depth. I also describe what to do immediately after a training session (note: this is different than the optimal protocol for cognitive skill training) and as you progress to more advanced levels of performance. I also cover the science of skill-based visualization which does have benefits, but only if done correctly and at the correct times. I discuss auto-replay of skill learning in the brain during sleep and the value of adding in post-training ‘deliberately idle’ sessions. I cover how to immediately improve limb-range-of-motion by leveraging cerebellum function, error generation, optimal repetition numbers for learning and more. As always, scientific mechanism, peer-reviewed studies and science-based protocols are discussed.

    Thank you to our sponsors:

    • Belcampo - https://belcampo.com/huberman
    • InsideTracker - https://insidetracker.com/huberman
    • Athletic Greens - https://athleticgreens.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab

    Timestamps:

    • 00:00:00 Introduction
    • 00:06:28 Skill Acquisition: Mental & Physical
    • 00:08:40 Clarification About Cold, Heat & Caffeine
    • 00:12:45 Tool: How To Quickly Eliminate the Side-Stitch ‘Cramp’ & BoostHRV Entrainment
    • 00:16:08 Physical Skills: Open-Loop Versus Closed-Loop
    • 00:18:50 Three Key Components To Any Skill
    • 00:21:00 Sources of Control for Movement: 1) CPGs Govern Rhythmic Learned Behavior
    • 00:23:30 Upper Motor Neurons for Deliberate Movement & Learning
    • 00:25:00 Lower Motor Neurons Control Action Execution
    • 00:25:26 What To Focus On While Learning
    • 00:27:10 The Reality of Skill Learning & the 10,000 Hours Myth
    • 00:28:30 Repetitions & The Super Mario Effect: Error Signals vs. Error Signals + Punishment
    • 00:34:00 Learning To Win, Every Time
    • 00:39:26 Errors Solve the Problem of What Focus On While Trying to Learn Skills
    • 00:43:00 Why Increasing Baseline Levels of Dopamine Prior To Learning Is Bad
    • 00:44:40 The Framing Effect (& Protocol Defined)
    • 00:46:10 A Note & Warning To Coaches
    • 00:48:30 What To Do Immediately After Your Physical Skill Learning Practice
    • 00:53:48 Leveraging Uncertainty
    • 00:56:59 What to Pay Attention To While Striving To Improve
    • 01:04:45 Protocol Synthesis Part One
    • 01:07:10 Super-Slow-Motion Learning Training: Only Useful After Some Proficiency Is Attained
    • 01:11:06 How To Move From Intermediate To Advanced Skill Execution faster: Metronomes
    • 01:16:44 Increasing Speed Even If It Means More Errors: Training Central Pattern Generators
    • 01:19:12 Integrated Learning: Leveraging Your Cerebellum (“Mini-Brain”)
    • 01:22:02 Protocol For Increasing Limb Range of Motion, Immediately
    • 01:28:30 Visualization/ Mental Rehearsal: How To Do It Correctly
    • 01:33:50 Results From 15 Minutes Per Day, 5 Days Per Week Visualization (vs. Actual Training)
    • 01:35:34 Imagining Something Is Very Different Than Actually Experiencing It
    • 01:37:58 Cadence Training & Learning “Carryover”
    • 01:39:00 Ingestible Compounds That Support Skill Learning: Motivation, Repetitions, Alpha-GPC
    • 01:43:39 Summary & Sequencing Tools: Reps, Fails, Idle Time, Sleep, Metronome, Visualization
    • 01:46:20 Density Training: Comparing Ultradian- & Non-Ultradian Training Sessions
    • 01:49:24 Cost-Free Ways to Support Us, Sponsors & Alternate Channels, Closing Remarks

    Supercharge Exercise Performance & Recovery with Cooling | Episode 19 May 10, 2021

    This episode I explain the science of heating and cooling the body, a process called thermoregulation-- and how to apply that knowledge to significantly improve physical performance. I describe the three areas of our body that can remove heat (or bring heat into the body) faster than anywhere else, why that is so, and how proper cooling of these areas with specific protocols can allow people to perform 200-600% more volume and repetitions of resistance exercises at the same weight loads, or to run, cycle or swim significantly further. I also describe how to use directed cooling of so-called glabrous skin: the bottoms of feet, palms and face, to significantly enhance recovery times from exercise. Also, why the common practices of trying to heat up or cool the body via the torso or whole-body submersion in cold can be inefficient and/or dangerous-- and the better alternatives. Finally, I discuss the temperature-effects of caffeine, alcohol and anti-inflammatory compounds. The information in this episode is focused on mechanisms and tools for increasing athletic or exercise performance.

    Thank you to our sponsors:

    • InsideTracker - https://insidetracker.com/huberman
    • Helix - https://helixsleep.com/huberman
    • Theragun - https://theragun.com/huberman

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab

    Timestamps:

    • 00:00:00 Introduction
    • 00:05:08 Physical Performance & Skill Learning
    • 00:06:40 Optimal Learning Protocol (Recap): 4 Steps
    • 00:08:31 Variables Impacting Physical Performance
    • 00:10:00 Temperature Is the Dominant Variable
    • 00:12:08 Understanding Mechanism Is Key
    • 00:13:42 Heat: The Enemy of All Performance (& Why)
    • 00:16:30 Blood Flow & Sweating & Piloerection
    • 00:22:35 Heat Is What Limits Effort: Even If You Feel Fine/Motivated
    • 00:25:29 Proper Cooling Can Double, Triple, Quadruple (Or More) Your Ability
    • 00:26:42 Heat Induced Confusion & Death
    • 00:30:02 The Three Body Parts Best For Heating & Cooling Your Whole Body
    • 00:31:38 Face, Palms, Bottoms of Feet; Glabrous Skin
    • 00:33:00 Arterio-Venous Anastamoses (AVAs) Are Super Cool(ing)!
    • 00:37:15 Palmar Cooling Can Supercharge Your Athletic Performance
    • 00:38:35 ATP, Pyruvate Kinase & Heat
    • 00:40:55 Palmer Cooling Outperforms Anabolic Steroids Several-Fold
    • 00:43:45 Increasing Endurance, Willpower & Persistence
    • 00:46:33 Cardiac Drift, & Moving the ”I Quit” Point
    • 00:50:44 Deliberate Heating: Myths and Better Protocols
    • 00:53:20 Protocols For Self-Directed Cooling To Vastly Improve Performance
    • 00:59:23 How To Use Cold To Recover Faster & More Thoroughly
    • 01:02:05 Ice Baths & Cold Showers Can Prevent Training Progress: mTOR, etc.
    • 01:06:29 Alcohol, Caffeine, NSAIDs: Their Temperature Effects Matter
    • 01:09:44 Are Stimulants Counter Productive For Performance? It Depends.
    • 01:12:00 The Caffeine Rule & “Caffeine Adaptation”
    • 01:14:20 NSAIDs for Training: Performance Enhancements & Risks
    • 01:17:00 The Best Way to Explore Your Own “Parameter Space”
    • 01:18:35 Tools: How To Try
    • 01:21:35 Cost-Free Support, & Additional Support & Resources

    Boost Your Energy & Immune System with Cortisol & Adrenaline | Episode 18 May 03, 2021

    This episode I describe the biology of two essential hormones we all make: cortisol and adrenaline (also called epinephrine). Cortisol and adrenaline powerfully regulate our levels of energy, focus and immune system function. I describe various science-supported tools and practices to increase or decrease cortisol and/or adrenaline, depending on one's specific needs and goals. I also describe the biology of nootropics, and how cortisol and adrenaline can improve or degrade learning. Finally, I review the scientific data and tools for timing the release of these hormones to improve memory, energy and immune system function.

    Thank you to our sponsors:

    • InsideTracker - https://insidetracker.com/huberman
    • Athletic Greens - https://athleticgreens.com/huberman
    • Headspace - https://headspace.com/specialoffer

    Our Patreon page:

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Social:

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab

    Links:

    • Intermittent Fasting & Growth Hormone Mechanism https://pubmed.ncbi.nlm.nih.gov/29233536/
    • Habitual Coffee Drinking & Changes In Brain Connectivity https://pubmed.ncbi.nlm.nih.gov/33875801/

    Timestamps:

    • 00:00:00 Introduction
    • 00:05:41 Energy & Your Immune System, & Learning Faster
    • 00:08:34 Why & How Intermittent Fasting Increases Growth Hormone
    • 00:11:56 Why Your Stomach Growls
    • 00:13:09 Hot Baths & Hormones
    • 00:14:35 Energy, Adrenaline (Epinephrine), & Cortisol
    • 00:15:48 Cortisol & Cholesterol, Competition With Testosterone & Estrogen
    • 00:17:54 Adrenaline (Epinephrine) Is Your (Immune Systems) Best Friend
    • 00:18:48 Cortisol Basics In Two (Actually 1) Minute/s
    • 00:19:48 Adrenaline Basics In Two Minutes
    • 00:21:32 Tool: Time Your Cortisol Peak To Waking Using Specific Light Intensities
    • 00:27:20 Brief Increases In Cortisol & Adrenaline Boost Energy, Focus & Immunity
    • 00:30:04 Ways To Increase Adrenaline, Epinephrine & Cortisol & Why That Is Good
    • 00:35:00 Does Mindset During Stress Matter?
    • 00:36:15 Protocols: Adrenaline Breathing Described
    • 00:39:00 Practices To Increase Energy Without Increasing Stress
    • 00:45:00 Using Stressors to ENHANCE Our Immune System: Science & Tools
    • 00:55:11 Timing Thyroid Release For Energy
    • 00:57:02 Adrenaline/Stress Increase Performance & Memory. IF They Are After Learning
    • 01:02:45 An Optimal Learning Protocol
    • 01:03:20 Coffee Changes Your Brain & Increases Connectivity Of “Anxiety Circuits”
    • 01:05:43 Nootropics: Two Kinds, & How & Why They Work, “Neural Energy”
    • 01:09:00 Biology of Comfort Foods: From Negative to Positive Feedback Loops
    • 01:14:00 Bombesin: Energy Without Eating
    • 01:15:00 How Stress Makes Our Hair Gray, & How To Prevent Stress-Induced-Graying
    • 01:18:05 Blunting Chronic Cortisol, Including: Ashwagandha & Science Of
    • 01:25:50 Licorice Increases Cortisol & Blood Pressure, & Reduces Testosterone (by Glycyrrhizin)
    • 01:28:50 Apigenin: Anti-Cortisol
    • 01:29:53 Protocols For Optimizing Energy & Immune System Function (& Learning)
    • 01:37:00 When Fasting, Exercise, Cold & Intense Breathing Become Detrimental
    • 01:39:00 Prescription Compounds
    • 01:39:47 Tools For Accessing Alert & Calm States of “Energy”: Separating The Brain & Body
    • 01:42:11 Ways To Apply Knowledge Presented Today
    • 01:43:20 No-Cost Ways To Support Us, Feedback, Sponsors, Patreon, Partners, “Office Hours”

    How to Control Your Metabolism by Thyroid & Growth Hormone | Episode 17 Apr 26, 2021

    This episode discusses metabolism and how our thyroid hormone and growth hormone control our metabolism. I also clarify that metabolism isn't just about burning energy, it’s about converting energy from different sources into fuels for building and repairing our tissues such as muscle, brain, and tendons and mobilizing energy from body fat storage. I discuss the role of iodine, selenium, and salt for thyroid health, and how specific exercise protocols, amino acids and temperature can dramatically shift levels of growth hormone release in waking and in sleep. I also describe the current landscape of prescription compounds, peptides and other factors for changing levels of thyroid and growth hormone, and some of their risks. Throughout the episode, mechanisms and tools grounded in specific mechanisms are discussed.


    Sponsors

    • Four Sigmatic - http://foursigmatic.com/huberman
    • Blinkist - http://blinkist.com/huberman
    • Munk Pack - http://munkpack.com - Use code: huberman

    Patreon page

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    • http://www.thorne.com/u/huberman

    Study on thermal stress and hormones

    • Endocrine Effects of Repeated Hot Thermal Stress and Cold Water Immersion in Young Adult Men

    Timestamps

    • 00:00:00 Introduction
    • 00:06:05 Thyroid & Growth Hormone
    • 00:08:44 Food Shapes: Do They Matter?
    • 00:11:43 Stevia: Naming & Impact
    • 00:13:30 Metabolism 101: Your Brain the Furnace
    • 00:17:33 Releasing Hormones From Your Brain, Stimulating Hormones from Your Pituitary
    • 00:21:04 Thyroid Hormone’s Real Effects: Growth, Repair and Energy Consumption of Tissues
    • 00:22:45 Iodine, L-Tyrosine & Selenium: The Trio Essential For Thyroid Function
    • 00:26:05 How Much Iodine Do We Need? By Food, Supplement or Ocean Air
    • 00:28:09 Selenium For Thyroid: Brazil Nuts & Other Valuable Sources
    • 00:33:05 Selenium For Pregnancy, Prostate Cancer Risk, Acne
    • 00:35:20 “Clean Eating” Downsides: Cruciferous Vegetables, Leeching Iodine
    • 00:39:00 Other Benefits of Iodine: Reducing Inflammation
    • 00:41:00 Why & How Increased Thyroid Increases Metabolism
    • 00:42:12 What To Eat To Support Your Brain
    • 00:43:00 Hyperthyroidism (Too Much) & Hypothyroidism (Too Little)
    • 00:44:35 Menstruation: Thyroid Carbohydrate & Sugar Craving
    • 00:45:33 Ketogenic Diet & Its Effects On Thyroid, Rebound Weight Gain
    • 00:48:39 Growth Hormone: What, Why & How
    • 00:51:18 Growth Hormone (GH) Changes Across The Lifespan & Risks of GH Therapy
    • 00:53:40 How To Powerfully Increase Growth Hormone: Know The Natural Triggers
    • 00:54:49 Not Eating Within 2hrs of Sleep: Keep Blood Glucose Low(ish) At Sleep
    • 00:55:43 Delta Wave Brain Activity Is the Trigger For Growth Hormone Release
    • 00:58:25 LOW Doses of Melatonin Supplementation For Increasing GH Release
    • 01:01:00 Book: Altered Traits, Binaural Beats? Delta Waves Access
    • 01:04:35 Specific Types & Duration of Exercise That Stimulate Growth Hormone & Warmups
    • 01:08:40 Keeping Low Blood Glucose & Ensuring A Cool Down For Two Phase GH Release
    • 01:10:36 Sex Differences For WHEN During Exercise Growth Hormone and IGF-1 Release Occurs: Males Have To Last Longer
    • 01:14:10 Supplements That Increase Growth Hormone 100-400% (or more): Arginine, Ornithine
    • 01:18:20 Arginine & Exercise Together Can Be Counter-Productive
    • 01:19:50 L-Citrulline Better For Arginine Than Arginine Itself (?!); & Blood Pressure Caution
    • 01:23:09 Growth Hormone Changes Across The Lifespan: No One Escapes
    • 01:26:00 Heat (& Cold) for Triggering Extremely Large Increases In Growth Hormone
    • 01:29:20 Specific Heat Protocols For Increasing Growth Hormone: Up To 16-Fold (?!)
    • 01:34:30 2021 (New) Study: Heat Increases GH, & Lowers Cortisol, No Effects On Testosterone, DHEA Or Prolactin
    • 01:36:00 Prescription Growth Hormone, & Emerging Peptides Therapeutics, Secretagogues Etc.
    • 01:42:25 Synthesis, Summary Of Actionable Steps For Increasing GH and Thyroid Hormone
    • 01:44:00 Zero Cost & Other Ways to Support Our Podcast; & Thank You!

    How Hormones Control Hunger, Eating & Satiety | Episode 16 Apr 19, 2021

    This episode I discuss how hormones from our gut, liver, pancreas and brain control our appetite-- and the specific tools we can use to adjust those hormones in order to achieve specific goals. I explain the brain areas that control our desire to eat, and our desire to stop eating. I discuss a hormone we all can make that is regulated by UV-rays from sunlight that reduces our appetite. I also explain that when we eat controls our appetite and not the other way around (and how to leverage that fact). I describe how we are basically always eating until we reach a threshold level of fatty acids and amino acids in our gut and the factors that can alter that signaling and make us eat far more than we need. I also explain how insulin, glucose and glucagon work, why cholesterol is so key for ovary, adrenal, liver and testes function and how the ketogenic diet impacts glucose and thyroid levels. As always, I describe many tools: specific supplements, prescription compounds, specific types (and timing) of exercise to regulate hormones, specific timing and types of eating, ways to reduce sugar cravings by triggering release of the hormone CCK, and more.

    Note: A future episode will cover Thyroid hormone. Also, I mis-spoke when explaining POMC neurons. I said “P-M-O-C” but should have said “POMC”. Apologies. The name I gave for what POMC is, however, was correct: "proopiomelanocortin".

    Thank you to our sponsors:

    • InsideTracker - http://insidetracker.com/huberman
    • Athletic Greens - http://athleticgreens.com/huberman
    • Munk Pack - http://munkpack.com - Code: huberman

    Patreon:

    • https://www.patreon.com/andrewhuberman

    Supplements (Thorne):

    • http://www.thorne.com/u/huberman

    Links:

    • Dr. Lustig’s Lecture
    • Paper In Cell Metabolism On Processed Food Effects

    Timestamps:

    • 00:00:00 Introduction
    • 00:06:59 Hunger: Neural & Hormonal Control
    • 00:08:32 Chewing & Hunger
    • 00:11:05 Siamese Rats Reveal the Importance of Hormones In Hunger
    • 00:13:08 Neurons That Powerfully Control Hunger by Releasing Specific Hormones
    • 00:16:28 Anorexia & Extreme Overeating
    • 00:16:57 Why Sunlight Suppresses Hunger: a-Melanocyte Stimulating Hormone (a -MSH)
    • 00:20:03 Blue-blockers, Injecting a-MSH: Instant Tan & Priapism
    • 00:22:30 Ghrelin: A Hormone That Determines When You Get Hungry, & That You Can Control
    • 00:24:40 Meal Timing Determines Hunger, Not the Other Way Around
    • 00:27:20 Satchin Panda, Circadian Eating & Intermittent(ish) Fasting
    • 00:29:35 How To Rationally Adjust Meal Schedules: The 45min Per Day Rule
    • 00:33:02 CCK (Cholecystokinin): A Hormone In Your Gut That Says “No Mas!”
    • 00:34:55 Eating For Amino Acids, Fatty Acids & Sugar
    • 00:39:05 L-Glutamine: Stimulates the Immune System & Reduces Sugar Cravings
    • 00:43:42 Things To Avoid: Emulsifiers; Alter Gut Mucosa & Nutrient Sensing
    • 00:49:32 “A Calorie Is NOT A Calorie” After All
    • 00:52:36 Insulin & Glucose: Hyperglycemia, Euglycemia, & Hypogylcemia
    • 00:56:12 The Order Your Eat Foods Matters: Managing Your Blood Glucose & Glucagon
    • 01:02:40 Movement, Exercise & GLUT-4
    • 01:04:50 Why Sugar Stimulates Your Appetite
    • 01:05:40 Keeping Blood Sugar Stable With Specific Exercises, The Power Of Insulin Sensitivity
    • 01:07:55 High-Intensity Exercise, Glycogen & Metabolism
    • 01:10:28 Cholesterol, HDL, LDL & Glucose Management: Ovaries, Testes, Liver, Adrenals
    • 01:15:00 Prescription Compounds That Reduce Blood Glucose: Metformin
    • 01:16:45 Berberine: A Potent Glucose Buffer That Also Adjusts Cholesterol Levels, Canker Sores
    • 01:22:05 Chromium, L-Carnitine, Ginseng, Caffeine, Magnesium, Stevia, Vitamin B3, & Zinc
    • 01:24:34 Acids: Vinegar, Lemons & Limes & False Alkalinity
    • 01:26:40 Ketogenic Diets (In Brief): Effects On Blood Glucose, Thyroid Hormones
    • 01:28:10 Diabetes, Filtering Blood, Sweet Urine
    • 01:31:08 The Power of GLP-1 & Yerba Mate For Controlling Appetite, Electrolytes
    • 01:35:19 Summary & Notes About Thyroid, Estrogen, Testosterone
    • 01:37:20 Zero Cost & Sponsor-Based Ways To Support The Huberman Lab Podcast

    How to Optimize Testosterone & Estrogen | Episode 15 Apr 12, 2021

    In this episode, I discuss testosterone and estrogen hormones and how they impact the brain, body, and behavior after puberty. I also discuss how various behaviors such as exercise (resistance and endurance training) and sex or observing sex impact these hormones and their levels. I ask: "what specifically is it about such activities that impact testosterone and estrogen?"; the resounding theme is that when our nervous system is activated in particular ways, it drives our endocrine system and vascular system to activate or repress certain hormone networks in predictable ways. I also discuss peer-reviewed studies and protocols addressing (at a mechanistic level) how light, cold and heat, and respiration (breathing) can positively or negatively impact testosterone and estrogen. We discuss specific supplements and compounds that peer-reviewed studies illustrate can adjust testosterone and estrogen levels by changing their binding to other proteins, raising them directly, or changing other hormones released from the brain and pituitary. I discuss optimization in the normal reference ranges for these hormones, and I discuss pheromones, apnea, menstrual cycles, menopause and andropause.


    Sponsors

    • Four Sigmatic - https://foursigmatic.com/huberman
    • Blinkist - https://blinkist.com/huberman
    • Theragun - https://theragun.com/huberman
    • InsideTracker - https://insidetracker.com/huberman


    Patreon

    • https://www.patreon.com/andrewhuberman

    Supplements (Thorne)

    • https://www.thorne.com/u/huberman


    References

    • Examine
    • "Behavioral Endocrinology”


    Timestamps

    • (00:00:00) Introduction
    • (00:05:50) Hormone Optimization
    • (00:07:00) Salutogenesis: A Powerful Way to Conceptualize Health
    • (00:10:03) Estrogen and Testosterone: Sources, Levels and Ratios
    • (00:15:46) The Power of Competition, Plus: Anxiety, Persistence and Dopamine
    • (00:20:58) Testosterone and Libido Pre-Ovulation
    • (00:21:48) Estrogen and Sexual Receptivity; Libido In Males
    • (00:23:10) How Sex Behavior Impacts Testosterone: Observing vs. Actual vs. Abstinence
    • (00:26:46) Testosterone and Prolactin: Sex Seeking vs Pair Bonding
    • (00:27:30) DHEA (dehydroepiandrosterone): Effects on Levels/Ratios
    • (00:28:45) Behaviors That Decrease Testosterone (and Cortisol): Parenting and Prolactin
    • (00:31:24) How Illness Impacts Testosterone and Estrogen: Cytokines, e.g., IL-6
    • (00:33:20) How Exactly Do Behaviors Change Hormones?
    • (00:34:18) Pheromones: Miscarriage, Menstrual Cycles, Puberty Onset, and Mate Recognition
    • (00:43:33) Apnea: A Powerful Bi-Directional Influence On Estrogen and Testosterone
    • (00:47:44) Mouth vs. Nose Breathing and Hormone Levels: Effects Via Sleep and Direct Effects
    • (00:51:11) How Sleep Adjusts Cortisol/Testosterone and Cortisol/Estrogen Ratios
    • (00:53:49) 02:CO2 Ratios, Nasal Breathing During Exercise
    • (00:56:30) Light Viewing Patterns and Hormones: Dopamine, GnRH
    • (00:57:44) Spring Fever: Tyrosinase, Hair Color, Mating Frequency
    • (01:04:39) Specificity of Hormone Effects
    • (01:06:03) Temperature: Cold and Hot Gonads
    • (01:14:10) How To Exercise: Types, Effort Level, Sequencing
    • (01:21:42) Cardio/Endurance vs. Resistance Training (First or Last?) Yes, It Matters
    • (01:24:41) Estrogen and Menopause: Compounds That May Ameliorate/Reverse Symptoms
    • (01:33:18) Nutrients That Optimize The Foundation For Hormones
    • (01:36:00) Opioids as Severe Hormone Disruptors
    • (01:37:23) Testes, Antlers and Ovaries
    • (01:38:50) Creatine and Increasing DHT (Dihydrotestosterone)
    • (01:40:14) Free and Bound Testosterone: SHBG (Sex Hormone Binding Globulin), Tongat Ali
    • (01:43:23) Nettles, Prostate, Boron, and Blood Brain Barrier
    • (01:45:27) Hormone Related Cancers: Sometimes Reducing Estrogen and Testosterone Is Optimal
    • (01:47:43) Ecdysteroids: Mimic Mammalian Hormones
    • (01:51:50) Optimizing Brain Hormones: Chorionic Gonadotropin, Fadogia Agrestis
    • (01:57:18) Additional Compounds, Liver Toxicity, Overall Milieu
    • (01:59:17) Summary: And Note About Additional Related Topic Coverage Coming

    Disclaimer


    The Science of Sexual Development | Episode 14 Apr 05, 2021

    In this episode, I discuss how hormones such as testosterone and estrogen and their derivatives impact the early development of the brain and body and their maturation. I review published data on environmental factors shown to powerfully alter hormone pathways in animals and humans and the effects of cannabis, alcohol and cell phones on testes, sperm, ovaries and hormones. I describe the predictable relationship between genes, beard growth and balding patterns, and the importance of estrogen for brain development in people of all chromosomal sexes. Finally, I discuss how the hormones we are exposed to in the womb shape the relative length of our finger digits, the sounds our ears make (yes you read that correctly), and how those correlate with people's self-reports of their sexual preferences. As always, basic information and tools are discussed.

    Thank you to our sponsors

    • InsideTracker - https://insidetracker.com/huberman
    • Helix Sleep - https://helixsleep.com/huberman
    • Athletic Greens - https://athleticgreens.com/huberman

    Our Patreon page

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    • https://www.thorne.com/u/huberman

    Social

    • Instagram - https://www.instagram.com/hubermanlab
    • Twitter - https://twitter.com/hubermanlab
    • Facebook - https://www.facebook.com/hubermanlab
    • Website - https://hubermanlab.com
    • Newsletter - https://hubermanlab.com/neural-network

    Links

    • Mood Meter
    • NSDR video
    • Cell Phones & Hormones
    • Finger-length ratios and sexual orientation (Nature)
    • Minireview: Organizational Hypothesis: Instances of the Fingerpost (Endocrinology)
    • LeVay Study in Science Magazine on Sexual Orientation Brain Dimorphism

    Timestamps

    • (00:00:00) Introduction
    • (00:06:47) Announcement: Mood Meter App Works Again
    • (00:08:00) Maximizing Learning from the Podcast
    • (00:10:00) New Non-Sleep Deep Rest Protocol, Spanish Subtitles
    • (00:11:35) Sexual Differentiation: Hormones, Neurons & Behavior
    • (00:14:15) Hormones Basics
    • (00:15:26) Sperm Meets Egg, Chromosomal Sex, Gonadal Sex,
    • (00:17:50) Y Chromosome Inhibition of Feminization
    • (00:19:00) Placenta Is An Endocrine (Hormone-Producing) Organ, Adrenal Testosterone
    • (00:19:45) Hormonal Sex, Morphological Sex
    • (00:21:04) Hormones Fast & Slow, Sex Steroids Can Turn On Genes
    • (00:23:06) Masculinization, Feminization, Demasculinization, Defeminization
    • (00:23:42) Primary Sexual Characteristics: DHT Drives Penis Development
    • (00:27:03) Secondary Sexual Characteristics
    • (00:27:43) Penis Sprouting: Guevedoces
    • (00:31:25) Estrogen, NOT Testosterone, Masculinizes The Brain
    • (00:33:15) Breast Development In Males: Aromatase; Puberty, & Steroids in Athletes
    • (00:34:50) Estrogen Powerfully Controls Brain Development In All Individuals
    • (00:35:19) Avoiding Hormonal Disruption In Children & Adults: Specific Oils, Creams, Etc.
    • (00:39:00) Environmental Endocrine Disruptors, Sperm Count Decline, Vincloziline
    • (00:44:20) Androgen Insensitivity Syndrome: Hormones Need Receptors, SARMS
    • (00:48:41) Estrogen Establishes “Masculine” Brain Circuits, Testosterone
    • (00:49:42) Cannabis, Alcohol: In Babies, Puberty & Adults
    • (00:56:25) Cell Phone Technology: Effects On Hormones, Ovaries, & Testicles
    • (01:02:33) Beards & Baldness Patterns Around the World, DHT, 5-alpha-reductase
    • (01:06:39) Creatine & DHT/Hair Loss
    • (01:08:20) Predicting Aging Rates By Pubertal Rates
    • (01:10:04) Hyenas, Baseball, & Jumbo Clitorises: Androstenedione
    • (01:14:26) Intersex Moles
    • (01:15:40) Marijuana Plants, Pollens: Plant-To-Animal “Warfare”
    • (01:20:08) Finger Length Ratios, Prenatal Hormone Exposure & Sexual Orientation
    • (01:29:13) Brain Dimorphisms with Sexual Orientation
    • (01:32:00) “Older Brother Effects”: Male Fetuses Might Change Mothers & Subsequent Brothers
    • (01:35:06) The Path Forward & A Warning
    • (01:35:55) Support & Your Questions


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    The Science of Emotions & Relationships | Episode 13 Mar 29, 2021

    In this episode, I discuss the biology of emotions and moods in the context of relationships. I focus on the science of how early infant-caregiver attachment, combined with adolescence and puberty shape our adult patterns of attachment. I explain the three universal aspects of emotions, the reality of right-brain versus left-brain personalities, and how the roots of adult attachment are also grounded in specific aspects of puberty. I review what factors determine when puberty starts and ends, and the role of oxytocin and other chemicals in controlling how we perceive and remember others. As always, I refer to various practical tools including new tools for understanding and predicting our emotions before they occur, and neurochemicals that shape human connection.

    Thank you to our sponsors

    • InsideTracker - https://insidetracker.com/huberman
    • ExpressVPN - https://expressvpn.com/huberman
    • Magic Spoon - https://magicspoon.com/huberman


    Our Patreon page

    • https://www.patreon.com/andrewhuberman


    Supplements from Thorne

    • https://www.thorne.com/u/huberman


    Links

    • NSDR - https://www.youtube.com/watch?v=pL02HRFk2vo
    • Mood Meter App - https://moodmeterapp.com/
    • Adolescence and The Brain - https://www.nature.com/articles/nature25770
    • Vagus and Depression - https://www.newyorker.com/magazine/2015/05/18/lighting-the-brain

    Timestamps

    • (00:00:00) Introduction
    • (00:05:10) Announcing New Cost-Free Resources: Captions, NSDR Link
    • (00:07:40) Emotions: Subjective Yet Tractable
    • (00:10:53) To Understand Your Emotions: Look At Infancy & Puberty
    • (00:15:21) Your First Feeling Was Anxiety
    • (00:17:36) What Are “Healthy Emotions”?
    • (00:19:03) Digital Tool For Predicting Your Emotions: Mood Meter App
    • (00:21:08) The Architecture Of A Feeling: (At Least) 3 Key Questions To Ask Yourself
    • (00:24:00) You Are An Infant: Bonds & Predictions
    • (00:27:57) Attachment Style Hinges On How You Handle Disappointment
    • (00:32:40) “Glue Points” Of Emotional Bonds: Gaze, Voice, Affect, Touch, (& Written)
    • (00:36:34) “Emotional Health”: Awareness of the Interoceptive-Exteroceptive Dynamic
    • (00:37:50) An Exercise: Controlling Interoceptive-Exteroceptive Bias
    • (00:42:19) Getting Out Of Your Head: The Attentional Aperture
    • (00:46:59) Puberty: Biology & Emotions On Deliberate Overdrive
    • (00:47:58) Bodyfat & Puberty: The Leptin Connection
    • (00:50:34) Pheromones: Mates, Timing Puberty, Spontaneous Miscarriage
    • (00:54:37) Kisspeptin: Robust Trigger Of Puberty & Performance Enhancing Agent
    • (00:58:26) Neuroplasticity Of Emotions: Becoming Specialists & Testing Emotional Bonds
    • (01:00:25) Testing Driving Brain Circuits For Emotion: Dispersal
    • (01:07:48) Science-Based Recommendations for Adolescents and Teens: The Autonomy Buffet
    • (01:11:05) “Right-Brain Versus Left-Brain People”: Facts Versus Lies
    • (01:14:18) Left Brain = Language, Right Brain = Spatial Awareness
    • (01:16:15) How To Recognize “Right Brain Activity” In Speech: Prosody
    • (01:18:32) Oxytocin: The Molecule of Synchronizing States
    • (01:20:09) Mirror Neurons: Are Not For “Empathy”, Maybe For Predicting Behavior
    • (01:23:00) Promoting Trust & Monogamy
    • (01:27:00) Ways To Increase Oxytocin
    • (01:28:34) Vasopressin: Aphrodisiac, Non-Monogamy and Anti-Bed-Wetting Qualities
    • (01:30:43) Bonding Bodies, Not Just Minds: Vagus Nerve, Depression Relief Via the Body
    • (01:35:18) A Powerful Tool For Enhancing Range & Depth of Emotional Experience
    • (01:30:43) MDMA and Other Psychedelic Compounds: Building A Framework
    • (01:38:54) Roundup, Various Forms of Support

    Title Card Photo Credit: Mike Blabac


    Disclaimer


    How To Increase Motivation & Drive | Episode 12 Mar 22, 2021

    This episode explains the science of motivation and drive. I describe how dopamine-- a chemical we all make in our brain, underlies our desire for and pursuit of our goals, as well as our capacity to move and experience pleasure. I describe how we can leverage specific behaviors, reward schedules and dopamine-prolactin balance to help ensure we can maintain motivation and capacity for pleasure over the long term. I also discuss dopamine in the context of ADHD, craving and addiction, and some absolutely amazing results about specificity of drug effects based purely on belief.


    Thank you to our sponsors

    • Athletic Greens - https://athleticgreens.com/huberman
    • Headspace - http://headspace.com/specialoffer
    • Magic Spoon - http://magicspoon.com/huberman


    Our Patreon page

    • https://www.patreon.com/andrewhuberman


    Supplements from Thorne

    • http://www.thorne.com/u/huberman


    Timestamps below

    • (00:00:00) Introduction
    • (00:04:22) Announcement: Spanish Subtitles
    • (00:05:06) Emotions, Addiction & Mindset
    • (00:06:22) Motivation & Movement: The Dopamine Connection
    • (00:07:29) A Double-Edged Dopamine Blade
    • (00:08:56) Dopamine Fundamentals: Precursor to Adrenalin
    • (00:10:15) The Reward Pathway: An Accelerator & A Brake
    • (00:12:10) Motivation= Pleasure Plus Pain
    • (00:14:14) The Dopamine Staircase: Food, Sex, Nicotine, Cocaine, Amphetamine
    • (00:16:15) Subjective Control of Dopamine Release
    • (00:17:40) Social Media and Video Games
    • (00:18:15) Addiction & Dopamine: Progressively Diminishing Returns
    • (00:18:48) Novelty, Sensation-Seeking & Anticipation
    • (00:20:15) Craving: Part Pain, Part Pleasure & Pain Always Prevails
    • (00:23:11) Desire Scales With Pain: The Yearning Function
    • (00:24:43) The Croissant Craving Circuit
    • (00:25:45) “Here and Now” Molecules: Serotonin, Bliss & Raphe Nucleus
    • (00:26:26) In Your Skin Or Out In the World
    • (00:27:25) Cannabinoids Lethargy & Forgetfulness
    • (00:28:15) The Almond Meditation
    • (00:29:30) Drugs That Shift Exteroception Versus Interoception
    • (00:30:36) Emotional Balance, Active & Passive Manipulation
    • (00:32:36) Procrastination: Leveraging Stress, Breathing, Caffeine, L-Tyrosine, Prescription Drugs
    • (00:37:04) When Enough Is Never Enough; How Dopamine Undermines Itself
    • (00:38:58) Dopamine-Prolactin Dynamics: Sex, Reproduction & Refractory Periods
    • (00:40:30) The Coolidge Effect: Novelty-Induced Suppression of Prolactin
    • (00:42:22) Vitamin B6, Zinc As Mild Prolactin Inhibitors
    • (00:43:25) Schizophrenia, Dopamine Hyperactivity and Side Effects of Anti-Dopaminergic Drugs
    • (00:45:08) Prolactin, Post-Satisfaction “Lows” & Extending the Arc of Dopamine
    • (00:48:00) The Chemistry of “I Won, But Now What?”
    • (00:49:00) Healthy Emotional Development: Child and Parent
    • (00:50:03) Never Say “Maybe” (Reward Prediction Error)
    • (00:52:02) Surprise!
    • (00:52:59) Are You Suppressing Your Drive and Motivation By Working Too Late?
    • (00:54:50) Disambiguating Pleasure and Drive: Dopamine Makes Us Anti-Lazy
    • (00:58:00) Beta-Phenylethylamine (PEA), & Acetyl L-Carnitine
    • (01:00:00) Attention Deficit Disorders, Cal Newport Books, Impulsivity & Obesity
    • (01:03:55) Leveraging Dopamine Schedules
    • (01:05:22) Subjective Control of Dopamine and Drug Effects: The “Adderall” Experiment
    • (01:09:03) Caffeine May Protect Dopamine Neurons, Methamphetamine Kills Them
    • (01:10:57) Nicotine: Dopamine, Possible Neuroprotection, Prolactin Increase
    • (01:11:53) Gambling, Intermittent Reinforcement, & Persistent Goal Seeking (Bad and Good)
    • (01:14:14) Intermittent Halting of Celebration; Enjoy Your Wins, But Not All of Them
    • (01:18:38) A Story Example of Intermittent Reward to Maintain Long-Term Drive and Motivation
    • (01:21:25) Corrections & Notes About Spanish Captions & Other Languages Soon
    • (01:24:00) Synthesis & Framework, Zero-Cost Support & A Note About Sponsors


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    How Foods and Nutrients Control Our Moods | Episode 11 Mar 15, 2021

    This episode explains the brain-body connections that allow the specific foods we eat to control our moods and motivation. I discuss the vagus nerve and its role in dopamine and serotonin release in the brain. I review Omega-3 fatty acids and the key role of the gut microbiome in supporting (or hindering) our mental and emotional states. Many actionable tools are reviewed and discussed related to fasting, ketogenic and plant-based diets, probiotics, fermented foods, fish oils, artificial sweeteners, specific supplements that promote dopamine and serotonin, and some remarkable behavioral (and belief) effects.


    Thank you to our sponsors

    • Theragun - http://theragun.com/huberman
    • InsideTracker - http://insidetracker.com/huberman
    • Athletic Greens - https://athleticgreens.com/huberman

    Our Patreon page

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    • http://www.thorne.com/u/huberman

    Links

    Artificial Sweeteners and Gut Microbiome:

    • https://www.nature.com/articles/nature13793
    • https://www.nature.com/articles/nature13752


    Anti-Depressive Effects of EPAs

    • https://bit.ly/3rFymeC


    Links to Studies on Supplements Discussed

    • https://examine.com

    Timestamps

    • (00:00:00) Introduction
    • (00:05:00) Emotions: Aligning Mind & Body
    • (00:06:41) Nutrients, Neurochemicals and Mood
    • (00:08:39) Primitive Expressions and Actions
    • (00:12:30) The Vagus Nerve: Truth, Fiction, Function
    • (00:15:45) “Vagus Stimulation”: A Terrible Concept
    • (00:16:35) Polyvagal Theory
    • (00:18:27) Vagus Senses Many Things, & Moves Our Organs
    • (00:19:35) Sugar Sensing Without Perception of Sweetness
    • (00:23:00) Eating-Induced Anxiety
    • (00:27:30) We Eat Until Our Brain Perceives “Amino Acid Threshold”
    • (00:29:45) Reward Prediction Error: Buildup, Letdown and Wanting More
    • (00:32:01) L-Tyrosine, Dopamine, Motivation, Mood, & Movement
    • (00:34:04) Supplementing L-Tyrosine, Drugs of Abuse, Wellbutrin
    • (00:38:29) Serotonin: Gut, Brain, Satiety and Prozac
    • (00:43:38) Eating to Promote Dopamine (Daytime) & Serotonin (Night Time)
    • (00:44:30) Supplementing Serotonin: Sleep, & Caution About Sleep Disruptions
    • (00:46:40) Examine.com An Amazing Cost-Free Resource with Links to Science Papers
    • (00:48:05) Mucuna Pruriens: The Dopamine Bean with a Serotonin Outer Shell
    • (00:51:00) Emotional Context and Book Recommendation: “How Emotions Are Made”
    • (00:54:55) Exercise: Powerful Mood Enhancer, But Lacks Specificity
    • (00:56:45) Omega-3: Omega-6 Ratios, Fish Oil and Alleviating Depression
    • (01:01:00) Fish Oil as Antidepressant
    • (01:02:40) EPAs May Improve Mood via Heart Rate Variability: Gut-Heart-Brain
    • (01:07:24) Alternatives to Fish Oil to Obtain Sufficient Omega-3/EPAs
    • (01:09:05) L-Carnitine for Mood, Sperm and Ovary Quality, Autism, Fibromyalgia, Migraine
    • (01:16:29) Gut-Microbiome: Myths, Truths & the Tubes Within Us
    • (01:21:55) Probiotics, Brain Fog, Autism, Fermentation
    • (01:25:20) Artificial Sweeteners & the Gut Microbiome: NOT All Bad; It Depends!
    • (01:28:00) Ketogenic, Vegan, & Processed Food Effects, Individual Differences
    • (01:33:20) Fasting-Based Depletion of Our Microbiome
    • (01:35:20) How Mindset Effects Our Responses to Foods: Amazing (Ghrelin) Effects!
    • (01:38:30) How Mindset Controls Our Metabolism
    • (01:41:03) Closing Comments, Thanks, Support & Resources


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Master Stress: Tools for Managing Stress & Anxiety | Episode 10 Mar 08, 2021

    This episode explains what stress is, and how it recruits our brain and body to react in specific ways. I describe the three main types of stress, and how two of them actually enhance the function of our immune system making us less vulnerable to infections. I review tools that allow us to control our stress in real-time, as well as tools to prevent long-term stress, burnout and stress-induced illness and anxiety. As always, we cover behavioral tools and supplements that can assist or hinder stress control.


    Thank you to our sponsors

    • InsideTracker - https://insidetracker.com/huberman
    • Helix Sleep - https://helixsleep.com/huberman

    Our Patreon page

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    • https://www.thorne.com/u/huberman

    Timestamps

    • (00:00:00) Introduction
    • (00:04:41) Emotions: A Logical Framework of Brain-Body Loops
    • (00:10:29) Stress: The (Falsely Narrow) Animal Attack Narrative
    • (00:14:31) The Stress RESPONSE: Generic, Channels blood, Biases Action
    • (00:21:08) Tools to Actually Control Stress: Reduce Alertness or Increase Calm
    • (00:24:15) The Fastest Way to Reduce Stress In Real Time: “Respiratory Sinus Arrhythmia”
    • (00:29:45) The Fastlane to Calm
    • (00:34:53) Important Notes About Heart Rate Deceleration: Vaso-vagal Lag
    • (00:36:50) Cyclic Sighing For Calm and Sleep Induction
    • (00:37:57) Nasal Breathing For Cosmetic, Immune and Performance Enhancement
    • (00:38:46) Two Breathing Centers In The Brain
    • (00:39:45) Breathing For Speaking Clearly
    • (00:40:39) The 3 Types of Stress: Short, Medium and Long-Term
    • (00:42:10) Positive Effects of Short-Term Stress: Immunity and Focus
    • (00:45:32) Adrenalin (Epinephrine) Deploys Killer Immune Cells
    • (00:46:40) Cyclic Deep Breathing IS Stress: Wim Hof, Tummo & Super-Oxygenation
    • (00:50:58) Inflammation Is Useful and Good, In the Short Term
    • (00:52:02) Procrastination and Self-Manufactured Nootropics
    • (00:53:00) Relaxation Can Causes Illness
    • (00:54:30) Immune Activation Protocol
    • (00:55:20) Medium Term Stress: A Clear Definition
    • (00:56:07) Stress Threshold
    • (00:57:10) Stress Inoculation Tools: Separating Mind & Body, On Purpose
    • (00:59:50) Use Vision to Calm the Mind When the Body Is Agitated
    • (01:02:36) Beyond NSDR
    • (01:04:36) Long Term Stress: Definition, Measurement, Cardiovascular Risks
    • (01:06:30) Tools for Dealing With Long Term Stress
    • (01:08:20) The Oxytocin Myth
    • (01:09:15) Serotonin: Satiety, Safety
    • (01:12:00) Delight and Flexibility
    • (01:13:30) Chemical Irritants We Make But Can Control: Tackykinin
    • (01:15:40) Impactful Gratitude
    • (01:16:25) Non-Prescription Chemical Compounds For Additional Anti-Stress Support
    • (01:18:04) Melatonin: Cautionary Note About Adrenal Suppression
    • (01:19:15) Adrenal Burnout Is A Myth… But Why You Need to Know About It Anyway
    • (01:21:10) L-Theanine For Stress Reduction and Task Completion Anxiety
    • (01:23:00) Beware Taurine and Energy Drinks With Taurine
    • (01:23:30) Ashwagandha: Can Powerfully Lower Anxiety And Cortisol
    • (01:25:50) Examine.com Is An Amazing Free Resource
    • (01:26:20) How This All Relates to Emotions: State Versus Demand = Valence
    • (01:32:00) Modulating Reactivity, Mindfulness, & Functionality With Objective Tools
    • (01:34:00) Next Steps
    • (01:35:40) Topic Suggestions, Subscriptions and Reviews Please
    • (01:37:40) Additional Resources, Synthesis

    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Control Pain & Heal Faster with Your Brain | Episode 9 Mar 01, 2021

    In this episode, I describe the science of how and why pain arises in the body and brain, and how we can actively control our experience of pain. I discuss inflammation, stress, acupuncture, limb damage and Traumatic Brain Injury (TBI). I review protocols that leverage the lymphatic and nervous system to accelerate pain relief and healing in a variety of situations. Other topics discussed include how heat versus cold impacts neurons and wounds, red-light, sunlight, stem cells and more.


    Thank you to our sponsors

    • ExpressVPN - http://expressvpn.com/huberman
    • Athletic Greens - https://athleticgreens.com/huberman


    Our Patreon page

    • https://www.patreon.com/andrewhuberman


    Supplements from Thorne

    • https://www.thorne.com/u/huberman


    Links

    • The Ready State/Dr. Kelly Starrett: https://thereadystate.com
    • Instagram (@thereadystate): https://www.instagram.com/thereadystate
    • Twitter (@thereadystate): https://twitter.com/thereadystate
    • Love and Pain Study: https://academic.oup.com/painmedicine/article/15/6/947/1826529

    Timestamps

    • (00:00:00) Introduction/Avenues for Support
    • (00:04:58) Deliberate Unlearning
    • (00:06:43) Pain, Injury and Regeneration
    • (00:09:17) A System of Touch (Somatosensation)
    • (00:11:42) Pain and Injury are Dissociable
    • (00:15:19) Objective versus Subjective Control of Experience
    • (00:16:15) Plasticity of Perception
    • (00:16:41) Lack of Pain Is Self-Destructive; So Is Excessive Pain
    • (00:18:42) Homoculous, Ratonculous, Dogunculus
    • (00:19:05) “Sensitivity” explained
    • (00:21:30) Inflammation
    • (00:22:24) Phantom Limb Pain
    • (00:24:00) Top-down Relief of Pain by Vision
    • (00:26:41) From Deaf to Hearing Sounds
    • (00:28:10) Pain Is In The Mind & Body
    • (00:29:44) Recovering Movement Faster After Injury
    • (00:35:00) Don’t Over Compensate
    • (00:37:34) Concussion, TBI & Brain Ageing
    • (00:40:49) The Brain’s Sewage Treatment System: Glymphatic Clearance
    • (00:43:05) Body Position & Angle During Sleep
    • (00:44:30) Types of Exercise For Restoring & Maintaining Brain Health
    • (00:47:33) Ambulance Cells in The Brain
    • (00:49:20) True Pain Control by Belief and Context
    • (00:51:45) Romantic Love and Pain
    • (00:55:05) Dopaminergic Control of Pain
    • (00:57:15) Acupuncture: Rigorous Scientific Assessment
    • (01:07:32) Vagus Activation and Autonomic Control of Pain
    • (01:08:30) Inflammation, Turmeric, Lead and DHT
    • (01:11:40) Adrenalin: Wim Hof, Tummo, “Super-Oxygenation” Breathing
    • (01:14:53) Protocols For Accelerating Tissue Repair & Managing Pain
    • (01:17:55) Ice Is Not Always Nice (For Pain and Injury): Sludging, Fascia, Etc.
    • (01:22:02) Chronic and/or Whole Body Pain; Red-Light Therapy, Sunlight
    • (01:26:10) Glymphatics and Sleep
    • (01:26:29) Stem Cells, Platelet Rich Plasma (PRP: Shams, Shoulds and Should Nots
    • (01:31:38) Young Blood: Actual Science
    • (01:35:44) Synthesis, Support & Resources


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Optimize Your Brain with Science-based Tools | Episode 8 Feb 22, 2021

    In this episode, I describe how to access focused learning bouts, creative states, and the underlying neural circuitry involved. I frame this in the context of our daily 24-hour cycle in order to make it practical, clear and precise about timing. I review the role of fasting, meal timing and specific types of nutrients for promoting certain states of mind. I also review various other tools and biological factors that directly or indirectly gate brain function and that we can control. I answer commonly asked questions about the science of psychedelics, binaural beats, and visualization. Thank you for your interest in science!


    Thank you to our sponsors

    • InsideTracker - https://insidetracker.com/huberman
    • Athletic Greens - https://athleticgreens.com/huberman

    Our Patreon page

    • https://www.patreon.com/andrewhuberman

    Supplements from Thorne

    • https://www.thorne.com/u/huberman

    Links

    • Spike Jonze/Kenzo Perfume: https://www.youtube.com/watch?v=NoMqvniiEkk
    • Dr. Charles Czeisler, MD, Ph.D.: https://en.wikipedia.org/wiki/Charles_Czeisler
    • Reveri (Research Supported Hypnosis): https://www.reveri.com
    • The NSDR I do every day (30 min): https://www.youtube.com/watch?v=iEw5BkK9K9A&t=15s

    Timestamps

    • (00:00:00) Introduction
    • (00:04:53) The Daily (Learning) Routine
    • (00:07:13) Plasticity Is NOT the Goal
    • (00:09:26) No Obligation To Change
    • (00:09:59) Practical Plasticity Language
    • (00:13:37) Pillars of Neuroplasticity
    • (00:15:16) My Daily Routine: Chronotype Management
    • (00:17:20) Plasticity of the Wake-Sleep Circuit: Morning Light
    • (00:19:09) Delay Caffeine!
    • (00:21:19) Light, Black Coffee, Hydrate
    • (00:22:57) High Alertness, Linear Tasks/Learning
    • (00:25:12) Background Music/Noise: Yay or Nay?
    • (00:26:52) “GO” versus “NO-GO”: The Basal Ganglia & Dopamine
    • (00:28:37) Leveraging GO, NO-GO
    • (00:30:08) Non-Specific Action
    • (00:32:06) Clear, Calm, Focused: The GO, NO-GO Sweet Spot
    • (00:33:48) When Very Alert, Work In Silence; When Tired, Include Background Noise
    • (00:35:28) Temperaments Vary: And So Should This
    • (00:36:01) The 3 Hour-Long Post Waking Block
    • (00:36:20) Early Morning Exercise and GO Networks
    • (00:38:05) Fasting, Ketogenic Diets, & Food Volume
    • (00:39:41) Sodium/Electrolytes
    • (00:40:57) Avoiding Hot Lunch, Food Pre-Occupation
    • (00:42:01) Post Lunch Low/No Cognitive Load
    • (00:42:56) Hydration, NSDR, Nap
    • (00:44:54) Creativity Work
    • (00:46:26) Creativity Is A Two-Part Phenomenon
    • (00:51:15) Psychedelics
    • (00:58:20) Afternoon Light As Insurance
    • (01:00:26) Evening Nutrition
    • (01:01:21) Repacking Glycogen: Hormonal Factors
    • (01:04:11) Pre-Sleep Anxiety: Normal and Easy To Solve
    • (01:07:08) The Power of Objective Tools
    • (01:08:14) Visualization
    • (01:11:34) Mini-Synthesis
    • (01:13:31) Resetting Your Clock
    • (01:15:55) Don’t Trust the Mind Now
    • (01:16:59) Two, (Maybe 3) Optimization Bouts Per Day
    • (01:18:33) Organizational Logic
    • (01:20:22) Wim Hof Breathing, Binaural Beats, Ice Baths, Etc.
    • (01:24:42) Variation Among People, and Dogs
    • (01:25:49) Accurate Versus Exhaustive
    • (01:27:57) Familiar and New Ways To Support


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    How to Learn Faster by Using Failures, Movement & Balance | Episode 7 Feb 15, 2021

    In this episode, I discuss how we can use specific types of behavior to change our brain, both for sake of learning the movements themselves and for allowing us to learn non-movement-based information as well. I describe the key role that errors play in triggering our brains to change and how the vestibular (balance) system can activate and amplify neuroplasticity. As always, I cover science and science-based practical tools. Thank you in advance for your questions and for your interest in science!


    Thank you to our sponsors

    • Headspace - http://headspace.com/specialoffer
    • Athletic Greens - http://athleticgreens.com/huberman
    • Madefor - https://getmadefor.com/ -- code: Huberman


    Supplements from Thorne

    • https://www.thorne.com/u/huberman


    Timestamps below

    • (00:00:00): Introduction
    • (00:06:20): Nerves and Muscles
    • (00:12:00): Exercise alone won’t change your brain
    • (00:12:58): Behavior will change your brain
    • (00:13:30): Remembering the wrong things
    • (00:15:00): Behavior as the gate to plasticity
    • (00:15:45): Types of Plasticity
    • (00:17:32): Errors Not Flow Trigger Plasticity
    • (00:21:30): Mechanisms of Plasticity
    • (00:22:30): What to learn when you are young
    • (00:23:50): Alignment of your brain maps: neuron sandwiches 00:26:00: Wearing Prisms On Your Face
    • (00:29:10): The KEY Trigger Plasticity
    • (00:32:20): Frustration Is the Feeling to Follow (Further into Learning)
    • (00:33:10): Incremental Learning
    • (00:35:30): Huberman Free Throws
    • (00:38:50): Failure Specificity Triggers Specific Plastic Changes
    • (00:40:20): Triggering Rapid, Massive Plasticity Made Possible
    • (00:43:25): Addiction
    • (00:45:25): An Example of Ultradian-Incremental Learning 00:49:42: Bad Events
    • (00:51:55): Surprise!
    • (00:52:00): Making Dopamine Work For You (Not The Other Way Around)
    • (00:53:20): HOW to release dopamine
    • (00:55:00): (Mental) Performance Enhancing Drugs
    • (00:56:00): Timing Your Learning
    • (00:57:36): (Chem)Trails of Neuroplasticity
    • (00:58:57): The Three Key Levers To Accelerate Plasticity
    • (00:59:15): Limbic Friction: Finding Clear, Calm and Focused
    • (01:04:25): The First Question To Ask Yourself Before Learning
    • (01:05:00): Balance
    • (01:07:45): Cerebellum
    • (01:10:00): Flow States Are Not The Path To Learning
    • (01:11:18): Novelty and Instability Are Key
    • (01:14:55): How to Arrive At Learning
    • (01:15:45): The Other Reason Kids Learn Faster Than Adults
    • (01:19:25): Learning French and Other Things Faster
    • (01:22:00): Yoga versus Science
    • (01:32:00): Closing Remarks


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    How to Focus to Change Your Brain | Episode 6 Feb 08, 2021

    This episode introduces neuroplasticity—which is how our brain and nervous system learn and acquire new capabilities. I describe the differences between childhood and adult neuroplasticity, the chemicals involved and how anyone can increase their rate and depth of learning by leveraging the science of focus. I describe specific tools for increasing focus and learning. The next two episodes will cover the ideal protocols for specific types of learning and how to make learning new information more reflexive.


    Thank you to our sponsors

    • InsideTracker - https://insidetracker.com/huberman
    • Headspace - https://headspace.com/specialoffer
    • Madefor - https://getmadefor.com/ -- code: Huberman


    Supplements from Thorne:

    • http://www.thorne.com/u/huberman

    Reference

    • Time dilates after spontaneous blinking (Current Biology)


    Timestamps

    • (00:00:00) Introduction
    • 03:50) Plasticity: What Is it, & What Is It For?
    • 06:30) Babies and Potato Bugs
    • 08:00) Customizing Your Brain
    • 08:50) Hard-Wired Versus Plastic Brains
    • 10:25) Everything Changes At 25
    • 12:29) Costello and Your Hearing
    • 13:10) The New Neuron Myth
    • 14:10) Anosmia: Losing Smell
    • 15:13) Neuronal Birthdays Near Our Death Day
    • 16:45) Circumstances for Brain Change
    • 17:21) Brain Space
    • 18:30) No Nose, Eyes, Or Ears
    • 19:30) Enhanced Hearing and Touch In The Blind
    • 20:20) Brain Maps of The Body Plan
    • 21:00) The Kennard Principle (Margaret Kennard)
    • 21:36) Maps of Meaning
    • 23:00) Awareness Cues Brain Change
    • 25:20) The Chemistry of Change
    • 26:15) A Giant Lie In The Universe
    • 27:10) Fathers of Neuroplasticity/Critical Periods
    • 29:30) Competition Is The Route to Plasticity
    • 32:30) Correcting The Errors of History
    • 33:29) Adult Brain Change: Bumps and Beeps
    • 36:25) What It Takes to Learn
    • 38:15) Adrenalin and Alertness
    • 40:18) The Acetylcholine Spotlight
    • 42:26) The Chemical Trio For Massive Brain Change
    • 44:10) Ways To Change Your Brain
    • 46:16) Love, Hate, & Shame: all the same chemical
    • 47:30) The Dopamine Trap
    • 49:40) Nicotine for Focus
    • 52:30) Sprinting
    • 53:30) How to Focus
    • 55:22) Adderall: Use & Abuse
    • 56:40) Seeing Your Way To Mental Focus
    • 1:02:59) Blinking
    • 1:05:30) And Ear Toward Learning
    • 1:06:14) The Best Listeners In The World
    • 1:07:20) Agitation is Key
    • 1:07:40) ADHD & ADD: Attention Deficit (Hyperactivity) Disorder
    • 1:12:00) Ultra(dian) Focus
    • 1:13:30) When Real Change Occurs
    • 1:16:20) How Much Learning Is Enough?
    • 1:16:50) Learning In (Optic) Flow/Mind Drift
    • 1:18:16) Synthesis/Summary
    • 1:25:15) Learning With Repetition, Forming Habits

    As always, thank you for your interest in science!


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Understanding and Using Dreams to Learn and to Forget | Episode 5 Feb 01, 2021

    This episode is all about the two major kinds of dreams and the sorts of learning and unlearning they are used for. I discuss REM-associated dreams that control emotional learning and their similarity to various trauma treatments such as ketamine and EMDR. I also discuss Non-REM dreams and their role in motor learning and learning of detailed, non-emotionally-laden information. I relate this to science-backed tools for accessing more of the types of sleep and learning people may want. Other topics are listed in the time stamps below.


    Thank you to our sponsors

    • Helix Sleep - http://helixsleep.com/huberman
    • Athletic Greens - http://athleticgreens.com/huberman


    Supplements from Thorne

    • http://www.thorne.com/u/huberman


    Timestamps

    • (00:00:00) Introduction
    • (00:03:00) The Dream Mask
    • (00:06:00) Cycling Sleep
    • (00:08:10) Chemical Cocktails of Sleep
    • (00:13:00) Motor Learning
    • (00:16:30) High Performance with Less Sleep
    • (00:17:45) Rapid Eye Movement Sleep
    • (00:20:30) Paralysis & Hallucinations
    • (00:23:35) Nightmares
    • (00:24:45) When REM & Waking Collide
    • (00:25:00) Sleeping While Awake
    • (00:26:45) Alien Abductions
    • (00:29:00) Irritability
    • (00:30:00) Sleep to Delete
    • (00:32:25) Creating Meaning
    • (00:34:10) Adults Acting Like Children
    • (00:36:20) Trauma & REM
    • (00:37:15) EMDR
    • (00:39:10) Demo
    • (00:44:25) Ketamine / PCP
    • (00:45:45) Soup, Explosions, & NMDA
    • (00:48:55) Self Therapy
    • (00:50:30) Note About Hormones
    • (00:51:40) Measuring REM / SWS
    • (00:53:15) Sleep Consistency
    • (00:56:00) Bed Wetting
    • (00:58:00) Serotonin
    • (00:59:00) Increasing SWS
    • (00:59:50) Lucidity
    • (01:02:15) Booze / Weed
    • (01:03:50) Scripting Dreams
    • (01:04:35) Theory of Mind
    • (01:07:55) Synthesis
    • (01:10:00) Intermittent Sleep Deprivation
    • (01:11:10) Snoring Disclaimer
    • (01:11:40) New Topic
    • (01:15:50) Corrections
    • (01:17:25) Closing Remarks


    As always, thank you for your interest in science!


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Find Your "Temperature Minimum" to Defeat Jetlag, Shift Work & Sleeplessness | Episode 4 Jan 25, 2021

    In this episode, I discuss a simple and reliable measurement called your "temperature minimum" that you can use to rapidly adjust to new times zones when traveling and to offset the bad effects of nocturnal shift work. I also discuss tools for adjusting sleep and waking rhythms in babies, teens, new parents and the elderly.

    Thank you to our sponsors

    • Athletic Greens - https://athleticgreens.com/huberman
    • Headspace - https://headspace.com/specialoffer


    Supplements from Thorne

    https://www.thorne.com/u/huberman


    Timestamps

    • (00:00:00) - Introduction
    • (00:04:15) - The bedrock of sleep-rest cycles
    • (00:07:05) - Night owls and morning larks
    • (00:08:22) - “The perfect schedule”
    • (00:11:04) - The 100K Lux per morning goal
    • (00:15:15) - Keeping your biological clock set
    • (00:16:15) - Reset your cortisol
    • (00:21:22) - Jetlag, death and lifespan
    • (00:23:00) - Going East versus West
    • (00:28:45) - The key to clock control
    • (00:31:01) - Your Temperature Minimum
    • (00:36:30) - Temperature and Exercise
    • (00:41:20) - Eating
    • (00:42:50) - Go West
    • (00:44:15) - Pineal myths and realities
    • (00:51:13) - The Heat-Cold Paradox
    • (00:53:45) - Staying on track
    • (00:55:30) - Nightshades
    • (00:57:00) - Emergency resets
    • (00:57:30) - Psychosis by light
    • (00:58:05) - Shift work
    • (01:02:40) - The Temperature-Light Rule
    • (01:04:20) - Up all night: watch the sunrise?
    • (01:06:45) - Error correction is good
    • (01:08:20) - NSDR protocols/implementation
    • (01:10:44) - The frog skin in your eye (not a joke)
    • (01:16:39) - Why stress turns your hair white
    • (01:17:24) - Ovaries or testes?
    • (01:18:25) - Babies and bright light
    • (01:21:40) - Polyphasic sleep
    • (01:25:25) - Ultradian cycles in children
    • (01:27:38) - Teens and puberty
    • (01:29:50) - Light before waking for better sleep
    • (01:31:20) - Older people and circadian rhythms
    • (01:33:48) - Sleepy Supplements
    • (01:42:00) - Red Pills & Acupuncture
    • (01:43:50) - Highlights
    • (01:48:30) - Feedback and Support


    As always, thank you for your interest in science!


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Using Science to Optimize Sleep, Learning & Metabolism | Episode 3 Jan 18, 2021

    “Office Hours” — In this episode, I answer your most commonly asked questions about science-supported tools for accessing more alertness, better learning, and quality sleep. I also cover when to exercise, time meals, and how to systematically vary your temperature to achieve specific effects on your nervous system.

    Thank you to our sponsors

    • Athletic Greens - https://athleticgreens.com/huberman
    • InsideTracker - https://insidetracker.com/huberman


    Timestamps

    • (00:00:00) - Introduction
    • (00:05:50) - Moonlight & Fire
    • (09:25:00) - Red Light: Good & Bad
    • (00:15:45) - Why Blue-Blockers Are Unscientific
    • (00:19:20) - Eyeglasses, Contact Lenses & Windows
    • (00:22:05) - Adding Up Your Lights
    • (00:24:30) - “Netflix Inoculation” With Light
    • (00:25:25) - How The Planet Controls Your Energy
    • (00:27:00) - A Season For Breeding (?)
    • (00:31:15) - Melatonin / Serotonin
    • (00:33:50) - Epinephrine vs Adrenaline: Same? Different?
    • (00:35:00) - Exercise & Your Sleep
    • (00:40:30) - Neuroplasticity & Food/Chemicals/NSDR
    • (00:44:10) - Using Sound & Smell To Learn Faster
    • (00:46:45) - Dream Meaning & Remembering
    • (00:48:15) - Waking Up Paralyzed
    • (00:49:40) - Nap/Focus Ratios For Accelerated Learning
    • (00:52:45) - Hypnotizing Yourself
    • (00:54:05) - Smart Drugs
    • (01:01:10) - Magnesium: Yay, Nay, or Meh?
    • (01:02:10) - How Apigenin Works
    • (01:04:30) - Serotonin: Slippery Slope
    • (01:05:35) - The Frog Experiment
    • (01:08:35) - Temperature
    • (01:10:30) - Morning Chills
    • (01:28:00) - Eating For Heating
    • (01:30:30) - Vagal Pathways For Gut-Brain Dialogue
    • (01:31:50) - Sex Differences
    • (01:33:50) - Self Experimentation


    As always, thank you for your interest in science!


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Master Your Sleep & Be More Alert When Awake | Episode 2 Jan 11, 2021

    Today's episode provides a host of information on what makes us sleepy, sleep soundly, and feel awake and alert. It covers a broad range of tools for anyone wishing to improve their sleep and wakeful state. The science and logic for each tool is described. Please put your questions related to Episodes 1 & 2 in the comments section below so I can address them in Episode 3 "Office Hours".


    Thank you to our sponsors

    • Helix Sleep: http://helixsleep.com/huberman
    • Headspace: http://headspace.com/specialoffer


    Timestamps

    • (00:03:30): What Is Sleep Really For?
    • (00:06:15): Sleep Hunger
    • (00:09:00): Caffeine: Devil & Angel
    • (00:12:20): Timing Your Sleep Properly
    • (00:14:15): Release Your Hormones (At The Right Times)
    • (00:18:45): (Pineal) Melatonin Waring
    • (00:24:30): Strange Vision Is Good Vision
    • (00:32:50): Blue Light Is Great!
    • (00:37:00): The Real Problem With Smartphones
    • (00:38:30): Blind / Low Vision People
    • (00:39:45): Using Exercise & Food To Set Your Clock
    • (00:42:00): The Power of Sunset
    • (00:45:43): The Healthy Holes In Your Skull
    • (00:48:15): Bad Light
    • (00:51:11): Light Location
    • (00:53:00): Fire / Candlelight
    • (00:54:00): When To Eat
    • (00:54:40): How To Wake Up Earlier
    • (01:08:00): Using The Body To Control The Mind
    • (01:10:00) Drugs & Supplements
    • (01:18:00): Sleep Walking
    • (01:20:00): Office Hours


    Links to several of the tools mentioned in this episode are listed below.

    • 10 Min Yoga Nidra Script (no cost): https://youtu.be/M0u9GST_j3s
    • 35 Min Yoga Nidra Script (no cost): https://youtu.be/FroVfmOtaps
    • Research-Supported Hypnosis Scripts: https://www.reveri.com
    • Independent Supplement Research Site: https://examine.com


    Note: A special episode devoted to shift workers and jetlag is coming out soon


    As always, thank you for your interest in science!


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    How Your Brain Works & Changes | Episode 1 Jan 04, 2021

    Today’s episode provides an introduction to how the nervous system works to create sensations, perceptions, emotions, thoughts and behaviors, as well as how we can change our nervous system— a phenomenon known as neuroplasticity. The information sets the stage for all Huberman Lab Podcast episodes that follow by covering neurons, synapses, brain chemicals and the rhythms that control our ability to focus, learn and sleep… and more. Thank you for your interest in science. We'll see you next week!


    Sponsors

    • Athletic Greens: https://athleticgreens.com/huberman
    • InsideTracker: https://info.insidetracker.com/huberman


    Timestamps

    • (00:05:00): What is the Nervous System
    • (00:08:55): Deja Vu
    • (00:10:50): How War, Guns & Soap Shaped Our Understanding of the Brain
    • (00:13:30): Jennifer Aniston Neurons
    • (00:14:30): Sensations
    • (00:16:10): Magnetic Sensing & Mating
    • (00:17:30): Perceptions & The Spotlight of Attention
    • (00:18:30): Multi-Tasking Is Real
    • (00:20:10): Bottom-Up vs. Top-Down Control of Behavior
    • (00:21:15): Focusing the Mind
    • (00:24:30): Antidepressants
    • (00:27:40): Thoughts & Thought Control
    • (00:28:35): Actions
    • (00:33:20): How We Control Our Impulses
    • (00:36:25): Neuroplasticity: The Holy Grail of Neuroscience
    • (00:41:20): The Portal to Neuroplasticity
    • (00:46:40): Accelerating Learning in Sleep
    • (00:50:20): The Pillar of Plasticity
    • (00:55:00): Leveraging Ultradian Cycles & Self Experimentation


    Title Card Photo Credit: Mike Blabac


    Disclaimer


    Welcome to the Huberman Lab Podcast Dec 21, 2020

    Welcome to the Huberman Lab Podcast, a new podcast from Dr. Andrew Huberman. The podcast can also be found on YouTube.


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