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    Science

    From First Principles

    From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing.

    Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

    Advertise

    Copyright: © Krishna Choudhary and Lester Nare

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    Latest Episodes:
    3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels (EP. 4) Aug 19, 2025
    Show notes

    Interstellar visitor #3 is here. We unpack 3I ATLAS (why it’s moving so fast, why we finally saw a tail, and how Hubble/JWST—and maybe even Juno—could nail down its makeup). Then we dive into the Vera Rubin Observatory, the 32-gigapixel camera that will turn the entire sky into a time-lapse movie and supercharge discovery. Next: AI just boosted CRISPR by predicting and guiding DNA repair (Pythia), making edits cleaner—especially in non-dividing neurons. And we close with a crossover of dinos + particle physics: preserved T. rex blood vessels revealed by a synchrotron. Mystery Box: the viral “Black aliens” meme.



    Oldest Molecule, Programmable Proteins, Europa Radar & Light’s Double Life (EP. 3) Aug 14, 2025
    Show notes

    We go from the universe’s first chemistry to tomorrow’s designer biology, swing by Mars to tune Europa Clipper’s ice radar, and finish with a fresh take on the double-slit experiment.


    In this episode

    • The “oldest molecule” puzzle (HeH⁺), cooling the early universe, and why JWST’s findings matter
    • Programmable proteins: reassigning codons, recoding organisms, and real biosafety
    • Europa Clipper’s REASON radar test at Mars: frequencies, ice thickness & ocean clues
    • Double-slit, demystified: single photons, “which-path” info, and measurement reality

    Chapters
    00:00 Intro

    • 01:26 First molecule

    • 22:27 Programmable proteins

    • 43:05 Europa radar

    • 55:00 Double-slit

    • 1:15:03 Sign-off


    Hidden Star in Betelgeuse, Dancing Atoms, Ultra-High-Energy Cosmic Rays & VR Immunity (EP. 2) Aug 05, 2025
    Show notes

    Lester and Dr. Krishna dive into:

    • Beetlejuice & “Bracelet” – why a red super-giant may soon swallow its tiny partner

    • Atomic Harlem Shake – 0.15 Å resolution images of thermal jiggles in 2-D materials

    • Too Fast, Too Furious – IceCube’s constraints on proton fractions in 10²⁰ eV cosmic rays

    • Interstellar Google Maps – New Horizons proves star-pattern navigation works

    • Mind-Body Woo-Woo – VR coughs that literally raise your white-blood-cell count



    Earth’s 1-ms Day, Baby Solar Systems, Record Black Hole Crash, CRISPR Cancer Hack & AI Indiana Jones (EP. 1) Aug 01, 2025
    Show notes

    Last week the Earth finished a full rotation one millisecond early – but that’s just the opener.

    In this week’s From First Principles we dive into six mind-bending headlines with our trademark mix of hard science and light-hearted banter:

    Earth’s fastest spin ever recorded – what shaved a millisecond off the day and why your chakras are still safe.

    ALMA spots a “baby Earth” forming 1,300 light years away – the first direct look at rocky planets in the making.

    Biggest black-hole merger on record – 15 ☉ of mass vaporized into pure gravitational waves, detected by LIGO/Virgo/KAGRA.

    CRISPR reveals a vitamin-D “kill switch” for tumors – how silencing one gene in pancreatic & colon cancers triggers 4,000 downstream changes.

    A star that died… then died again – the first confirmed “double-detonation” white-dwarf supernova.

    DeepMind’s Aeneas AI deciphers broken Latin tablets – giving historians new text, provenance and dating in seconds.

    👋 Hosts • Lester Nare – storyteller & professional curiosity machine • Dr. Krishna Choudhary – Princeton-trained physicist & cosmic tour guide

    👍 Like what you hear? Hit Subscribe, ring the bell 🔔, and drop your questions for next week’s episode.


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