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Copyright: © Richard Jacobs
Greg Paulsen, Director of Applications Engineering at Xometry (xometry.com), discusses the work they do at Xometry, including an overview of on-demand manufacturing services.
Paulsen heads the Applications Engineering team that is responsible for handling special case projects that demand specialized attention to material selection, design-for-manufacturing, and technical engineering resources as well.
Paulsen discusses Xometry, and how they came to their company's name. He provides an overview of what they do—making manufacturing easier. He discusses how they have sought to revolutionize the established manufacturing industry by introducing AI (artificial intelligence) and machine learning. Their system allows customers to procure parts in one location, yet still take advantage of the talents of thousands of people in a gigantic manufacturing network.
He discusses sourcing of parts, technical data packages, communications, and the entire process from start to finish as manufacturers bring all the necessary elements together. But the system is slow, and thus Xometry enhances the entire chain so manufacturers can get pricing quotes and information more efficiently and faster.
Paulsen discusses customized manufacturing and set up costs, and as he states, there is a need for high level specification but quantities needed are not as high. He explains how Xometry can help customers find the right suppliers who can meet these specialized needs.
Continuing, Paulsen talks about quantities needed, touching on the processes in 3D printing and how improvements can speed up manufacturing times. Paulsen goes on to discuss the feedback customers can get right away after they input their data, and manufacturing/parts needs. As Paulsen states, they seek to create a 'knowledge nucleus' for clients and customers, so they can make all sorts of important decisions that will bring multiple, more efficient technologies to their manufacturing process.
Wrapping up, the manufacturing expert details how their solutions help customers to streamline their process for manufacturing. He discusses their typical and atypical clients, and he provides further information on raw goods, milling, and prototypes.
In this podcast:
Gastrointestinal (GI) cancers such as esophageal and stomach cancer are on the rise worldwide, with under-resourced populations being particularly affected. Early detection of GI changes that can lead to cancer requires endoscopy, a procedure that involves the insertion of a thin tube into the body to image the tissues, identify signs of disease, and deliver treatment. When endoscopy is either too expensive or simply unavailable in certain populations, otherwise preventable cancers can emerge.
In her work, gastroenterologist and director of the Baylor Global Innovation Center in Houston, TX, Dr. Sharmila Anandasabapathy, has two primary research interests: how to better prevent the development of GI cancers, and how to make early detection and treatment more accessible to underserved populations around the world. In order to address this very issue, Dr. Anandasabapathy and her team have developed an affordable, portable endoscopic tool capable of detecting precancerous cellular changes and acting as the medium through which treatments are delivered.
She discusses a range of important issues, including the following:
Is natural talent a real thing? Are human beings fundamentally different in that some are born with special capabilities, and others just aren't? How are very high levels of performance attained? And how would the answer to these questions impact who receives access to limited resources? These are a few of the questions that Karl Ericsson has been researching for almost 40 years now.
Ericsson joins the podcast to talk about a number of topics in this field of research, including child "prodigies," possible hallmarks of continuous success from childhood into adulthood in a particular domain, savants, in what ways certain abilities might actually be "natural" (or not), and the lack of overall evidence suggesting that genetics play a role in high levels of performance.
On today's podcast, you will discover:
Press play for the full conversation, and check out Ericsson's book, Peak: Secrets from the New Science of Expertise.
Ben Atkinson, of the Functional Health podcast (FunctionalHealthInfo.com), is a nutritionist and health enthusiast. In this informative podcast, Ben talks about holistic wellness, functional medicine, and overall holistic health.
Ben's podcast, and site, is a complete resource guide for all kinds of important information regarding professional recognition, health events, training, and more—happening across the country—for clinicians in the field, as well as trainees and the public.
Ben discusses his background and how he came to be interested in nutrition. As an overweight child, Ben became interested in body building at the age of 16, and this interest led him to learn about high protein diets—low in carbs and low in fat. When he saw fast results he became excited about this power of nutrition and decided to make it a part of his ongoing work. But over time he added in carbs and fats to increase energy, which provided clarity of mind. Taking from everything he learned, he began to see that nutrition was the key to not only how you look and feel, but also to prevent illness and restore health.
Ben discusses his intensive studies, and what he learned while gaining his master's. He discusses various modalities and the separations in the medical field, which he states need to come together and be more synchronized in order to best deliver options for good health practices. Ben discusses genes and how they contribute to various health outcomes, and he talks about the different people/cultures around the world and the diets that they exist upon. He discusses allergens, and how to eliminate them, and the various ways we can fine tune our bodies. Continuing, Ben talks about DNA testing, and other methods people can use to learn more about their bodies, markers, and health information.
In this podcast:
Renowned herbalist and nutritionist Donnie Yance talks about plant-based treatments with a focus on cancer management specifically. When you listen, you'll better understand
Founder, President, Chairman, and Lead Clinician at the Mederi Center, Donnie Yance has been involved in plant medicine for decades. He founded the Natura brand to make high quality botanical medicine.
At the Mederi Center, Yance works with cancer patients and their doctors from a quality of life and healthcare perspective under a specific order: first, they focus on the health of the patient with plant medicine to strengthen their healing capacity; then, they assess and alter accordingly the patient's micro environment and how it relates to the disease; and last, they targeting the cancer after identifying its molecular characteristics. Ultimately, the goal is to create a medicinal approach that does the most harm to the unhealthy cells with the least harm to the healthy.
Yance uses his extensive knowledge of extracts and botanicals to inhibit the capacity of the cancer cells to build resistant pathways. The Mederi Center also focuses on quality of life, offering tips to live longer with better healthcare.
For more, see the Mederi Center web site at https://medericenter.org/as well as a video featuring a Mederi Center patient called "That's Not Your Story" at https://www.youtube.com/watch?v=FUVu354ujnc.
Donnie Yance also has a website and a blog at https://www.donnieyance.com/
Consumer wireless broadband connection uses better technology than the industrial sector. Mr. Kantor explains why and how Ondas is changing this through software defined radio projects and other technologies. When you listen, you'll hear:
President, CEO, and cofounder of Ondas Networks, Stewart Kantor, discusses "mission critical IOT" (internet of other things) for the industrial sector. Ondas focuses on network connectivity for the industrial sector, including utility, natural gas, transportation, and commercial drone companies.
He explains that the technology in use by industrial companies has not been upgraded as it has for consumers because of a long list of challenges such as distance, cost, and data needs. Ondas is working on this upgrade through multiple means from software defined radio projects to specialized types of automation fitting the large geographical and upstream data needs.
Mr. Kantor discusses the ways in which these vulnerabilities played out in the California wildfires of 2019 and how his company is developing technology that could improve the situation from multiple angles. He describes what "licensed radio frequencies" are in terms of these improvements and why wireless broadband connections may never be the same.
For more, see www.ondas.com and find links to additional information.
P. Shannon Pendergrast, PhD, Chief Science Officer at Ymir Genomics (ymirgenomics.com), discusses his company's work in biomarker identification techniques.
Dr. Pendergrast holds a PhD from the Rutgers University Waksman Institute of Microbiology in Molecular Genetics. He completed his post-doctoral training at Cold Spring Harbor Laboratories. Dr. Pendergrast has over 12 years of experience as a scientist, executive, and entrepreneur.
Ymir Genomics seeks to provide new and innovative tools to facilitate the discovery of biomarkers from biofluids, to assist in the ongoing fight against human diseases. Dr. Pendergrast discusses the primary objectives of Ymir Genomics. Dr. Pendergrast talks in detail about their accomplishments and discoveries, including their efficient, rapid method for isolating extracellular vesicles, extracellular RNA, and/or extracellular protein directly from urine samples. Extracellular vesicles (EVs) are membrane-derived vesicles that can be released via different cell types, including hepatic stellate cells, hepatocytes, and immune cells in normal as well as pathological conditions.
The science researcher CSO discusses how they compare proteins using mass spectrometry, and how they look at the data. He talks in detail about their work studying liver-specific vesicles, exosomes, stability issues, and more. He discusses their processes in detail, discussing how they work with structures, proteins, RNA, etc.
Among the many important offerings Ymir delivers, they can also provide extracellular vesicle isolation protocol and bioinformatics protocol to discover biomarkers for prostate and bladder cancer. Dr. Pendergrast wraps up by discussing their current and future work.
In this podcast:
What can we learn from extracellular vesicles?
What can biomarkers tell us?
An overview of biomarker identification techniques
Dr. Annila, biophysics professor, explores the time and space relationship in this podcast. When you listen, you'll hear him discuss:
Early in his days as a new professor of biophysics, Dr. Annila of the University of Helsinki asked why there was no equation for evolution yet. After all, life is all about motion. That question took him on this voyage he explores in his book and in his research. He looks at the theory of evolution in terms of physics.
For example, he explains the time and space relationship like this: losing heat takes place over time. Photons that we lose as we cool off are not only carrying energy but also time. This means energy is carried over a period of time: energy and time go hand in hand and this can be a mathematical formula. Why? Because photons have a wavelength. A wavelength divided by the speed of light equals time. This makes time a concreate concept rather than an abstract.
He continues to explain that it is a contrived idea that evolution should be limited to animals and explains that there's nothing special in life versus nonlife according to his theories. Finally, this understanding changes how we approach many aspects of human existence. An understanding of everything as photons opens up a new understanding of all matter.
For more, see his university home page: https://www.mv.helsinki.fi/home/aannila/arto/index
Dr. Robin Smith, Lecturer in Physics at Sheffield Hallam University, UK, delivers an insightful overview of his work in nuclear physics research topics and experiments in nuclear physics.
Dr. Smith earned his Ph.D. in nuclear physics at the University of Birmingham under the guidance of Dr. C. Wheldon and Prof. M. Freer. He is a distinguished lecturer in physics and specializes in multiple fields, including the following: nuclear data, nuclear structure, nuclear astrophysics, radiation detection, atomic nuclei and more.
Dr. Smith talks about nuclear physics and general physics and how he came to his areas of specialty. As he explains, he undertook projects in his senior year at university that involved smashing nuclei, which really got his interest moving in the direction of nuclear physics. Dr. Smith explains why he studies the atomic nucleus in detail, discussing the building blocks—atoms, and historical perspectives on the atom. He explains the atom's structure and the density of the atomic nucleus, citing examples for comparison. Dr. Smith goes on to explain that in nature we have four fundamental forces that govern all matter within the universe—gravity, the electromagnetic force, the weak force, and the strong force. Dr. Smith details how these forces work, discussing gravity and its effects and the binding structures.
The nuclear physics expert discusses quantum mechanics, and how it is derived from the Schrödinger equation, which is a linear partial differential equation that precisely describes the general wave function, or state function, etc., of a quantum-mechanical system. Continuing, Dr. Smith discusses stars in our galaxy, the heavy elements, and the forces that exist, detailing how his research relates. He discusses carbon and excited states within nuclei and some of the theories that exist regarding molecules and molecular physics in general.
As Dr. Smith extends his discussion, he explains some of the methods they use to gather their scientific data. He explains how they study energies and what the data reveals in regard to decay processes. Regarding his research in colliding, Dr. Smith states that decay behavior, specifically regarding carbon-12, the most common of all-natural carbon isotopes, does appear to change dependent upon what projectile is being fired at the carbon-12. In essence, the environment does appear to affect the outcome of the reaction.
Wrapping up, Dr. Smith discusses the work and theories of Sir Fred Hoyle, the English astronomer who famously formulated the theory of stellar nucleosynthesis.
In this podcast:
Anita Öst, Medical Faculty at Linköping University, provides an overview of the current state of epigenetics research as she discusses
epigenetic inheritance in humans.
Anita seeks to understand and thereby manipulate epigenetic metabolic programs that are set up by parental cues as well as early life events in an effort to design new treatments for obesity and obesity-related diseases, etc.
Anita discusses the concept of epigenetics, which is the study of changes in organisms that can be caused by a modification of gene expression, as opposed to an alteration of the genetic code. She details the specific area of epigenetics she focuses on, which looks at how offspring will inherit information or change their phenotype based on their parents' environment, or stress. She explains why starvation or stress may lead to changes, and talks in depth about experiments with fruit flies that provided further information on theories related to epigenetic inheritance.
She discusses how weight affects flies, and how they look at fat by observing and measuring their triglycerides. And the research scientist explains what they learned by experimenting with weight gain in the test subjects and how that impacts offspring.
Continuing, the Linköping University researcher talks about experiments they performed with humans related to diet and sugar intake. She discusses their results, and how it affected sperm motility. Wrapping up, the researcher explains how these dietary and other effects have impacted their research and their considerations for other experimentation.
In this podcast:
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