Evidence Based Hair

Latest Episodes:

Season 6, Episode3 (Effect of Oral Minoxidil on Blood Pressure, Oral Minoxidil Use in Patients with High Blood Pressure and Arrhythmia) Nov 06, 2023

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ARTICLES COVERED THIS WEEK

STUDY 1:

Ong M et al (starts at 5:12). Low-dose oral minoxidil for androgenetic alopecia is not associated with clinically significant blood-pressure changes: a retrospective study. J Am Acad Dermatol. 2023 Oct 13:S0190-9622(23)02976-6.

Sanabria et al. Prospective cardiovascular evaluation with 24-h Holter and 24-h ambulatory blood pressure monitoring in men using 5 mg oral minoxidil for androgenetic alopecia. J Am Acad Dermatol. 2022 May 18;

Jimenez-Cauhe J et al. Before-after study with 24-hour ambulatory blood pressure monitoring after the first dose of 5 mg oral minoxidil. J Am Acad Dermatol. 2022 Dec;87(6):e235-e237

STUDY 2:

Imhof R et al (starts at 16:35). Safety and tolerability of low dose oral minoxidil monotherapy in female pattern hair loss: A retrospective review with longitudinal ambulatory blood pressure monitoring. JAAD Int. 2023 Aug 12:13:50-52.

Ramos PM et al. Minoxidil 1 mg versus minoxidil 5 % topical solution for the treatment of female-pattern hair loss: A randomized clinical trial. J Am Acad Dermatol Jan 2020;82(1):252-253.

STUDY 3:

Jimenez-Cauhe J et al (starts at 24:27). Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients. Actas Dermosifiliogr. 2023 Aug 29:S0001-7310(23)00679-8.

Vano-Galvan S et al. Safety of low dose oral minoxidil for hair loss: A multicenter study of 1404 patients. JAAD 2021; 84: 1644-51.

Sanabria B et al. Adverse effects of low dose oral minoxidil for

androgenetic alopecia in 435 patients. JAAD 2021; 84: 1175-78.

ARITCLES COVERED NEXT WEEK (PREVIEW)

Cook M et al. Use of low-level light therapy in management of central centrifugal cicatricial alopecia: A case series of four patients. Photodermatol Photoimmunol Photomed. 2023 Aug 23.

Workman K and Kindred C. Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib. JAAD Case Rep. 2023 Jul 28:39:109-111

Season 6, Episode 2 (A Closer Look at Randomized Controlled Trials and Real World Non RCT Data) Nov 04, 2023

Show notes

ARTICLES REFERENCED IN THIS EPISODE

Krauss A (starts at 12:44). Why all randomised controlled trials produce biased results. Ann Med. 2018 Jun;50(4):312-322.

Van Noreen R (starts at 15:33). Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? Nature. 2023 Jul;619(7970):454-458. Listen at https://youtu.be/_QLvzCr6nz4?feature=shared

Carlisle JB (starts at 16:28). False individual patient data and zombie randomised controlled trials submitted to Anaesthesia. Anaesthesia. 2021 Apr;76(4):472-479.

PREVIEW STUDIES FOR NEXT WEEK (SEASON 6, EPISODE 3)

Ong M et al. Low-dose oral minoxidil for androgenetic alopecia is not associated with clinically significant blood-pressure changes: a retrospective study. J Am Acad Dermatol. 2023 Oct 13:S0190-9622(23)02976-6. doi: 10.1016/j.jaad.2023.10.010. Online ahead of print.

Jimenez-Cauhe et al. Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients. Actas Dermosifiliogr. 2023 Aug 29:S0001-7310(23)00679-8.

Imhof R et al. Safety and tolerability of low dose oral minoxidil monotherapy in female pattern hair loss: A retrospective review with longitudinal ambulatory blood pressure monitoring. JAAD Int. 2023 Aug 12:13:50-52.

Season 6 Episode 1 (Baricitinib Response Timing, Real World Study of Baricitinib) Oct 24, 2023

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Studies Referenced in This Episode: Season 6 Episode 1

King B et al (starts at 4:07). When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials. Br J Dermatol. 2023 Sep 14:ljad253.

Gargiulo L et al (starts at 30:22). Effectiveness and safety of baricitinib in patients with severe alopecia areata: a 36-week multicenter real-world experience. J Dermatolog Treat. 2023 Dec;34(1):2268764.

Preview of Studies for New Week: Season 6 Episode 2

Krauss A. Why all randomised controlled trials produce biased results. Ann Med. 2018 Jun;50(4):312-322.

Carlisle JB. False individual patient data and zombie randomised controlled trials submitted to Anaesthesia. Anaesthesia. 2021 Apr;76(4):472-479.

Van Noorden R. Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? Nature. 2023 Jul;619(7970):454-458. Listen at https://youtu.be/_QLvzCr6nz4?feature=shared

Reminder of December 1, 2023 Deadline For Evidence Based Hair FellowshipTraining Program for Hair Loss Practitioners Oct 01, 2023

Show notes

On August 1, 2023, Dr Donovan announced the long awaited start of the Evidence Based Hair Fellowship training program. This is an online (virtual) training program for practitioners that wish to develop expertise in hair loss. The program runs Jan 2024 to August 2025 and participants meet once weekly for a three hour period (either on a Wednesday or a Thursday).

In this short recording, Dr Donovan updated listeners on the Evidence Based Hair Fellowship training program.

Interested participants may wish to watch video describing the full program at https://youtu.be/xWBT9sKWU_k?si=6TVCHw3lnNgb2_mk

or download the coarse syllabus at:

https://donovanmedical.com/donovan-hair-academy

Alopecia Areata Awareness Month - Recording from Sept 6 2023 Live Public Webinar Sep 10, 2023

Show notes

Alopecia Areata Awareness Month - Recording from Sept 6 2023 Live Public Webinar hosted by Dr Donovan.

Question 1 (starts at 3:50): Is the rate of alopecia areata going up ?

Question 2 (starts at 7:45). What blood tests should be ordered for someone with alopecia areata?

Question 3 (starts at 11:58). Do JAK inhibitors cure alopecia areata?

Question 4 (starts at 15:45). What treatments are possible for eyelash loss?

Question 5 (starts at 17:53). What other medical problems do patients with alopecia areata have?

Question 6 (starts at 20:29). My son is 3 years old and Alopecia. 1 year ago, hair loss started and his hair and eyebrows completely fell out. In the tests , it was determined that his intestinal flora was very disordered and he has lactose and gluten intolerance. There are some doctors who have found that Intestinal Flora Disorder and Leaky Gut Syndrome can cause some autoimmune diseases. I would like to know your thoughts on this subject.

Question 7 (starts at 26:58). Should I ask for a biopsy to prove the diagnosis of alopecia areata?

Question 8 (starts at 29:01). I am a 37 year old female and have alopecia areata. Will I pass this on to my children?

Question 9 (starts at 31:48). Does stress cause alopecia areata? I hear mixed views.

Question 10 (starts at 35:16). My 3 year old developed a small area of alopecia over the summer. What treatment is considered best?

Question 11 (starts at 41:12). Does low vitamin D make alopecia worse?

Question 12 (starts at 43:43). Myalopecia areata is becoming scarring. How is this possible?

Question 13 (starts at 47:13). Do you see loss of efficacy over time of JAK inhibitors and if so what would be the reason

Season 5, Episode 6 (Selenium Toxicity, Alopecia Neoplastica, Lymphema Distichiasis Syndrome, Eyebrow Hypotrichosis, Seasonal Shedding) Aug 30, 2023

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Season 5 Ep 6

Season 5, Episode 5 (CCCA Prognosis, CCCA in Males, Anagen Hairs in LPP, EPDS and NMSC and FD in Females) Aug 21, 2023

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STUDIES REFERENCED IN THIS EPISODE

Onamusi T et al (starts at 8:58). Clinical factors and hair care practices influencing outcomes in central centrifugal cicatricial alopecia. Arch Dermatol Res. 2023 May 15. doi: 10.1007/s00403-023-02630-5. Online ahead of print.

Erinolaoluwa F et al (starts at 11:59). Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin. JAAD Case Reports Feb 2020

Jackson TK et al (starts at 15:40). Central Centrifugal Cicatricial Alopecia in Males. J Am Acad Dermatol. 2023 Jul 24:S0190-9622(23)02399-X.

Melo RR et al (starts at 21:45). Positive Anagen Pull Test Predicting Lichen Planopilaris Activity. Dermatol Pract Concept. 2023 Jul 1;13(3):e2023140.

Shamloul N et al (starts at 29:14). Incidence and time to development of malignancies arising on the scalp of patients with erosive pustular dermatosis based on sex: A retrospective analysis. J Am Acad Dermatol. 2023 Jun 13;S0190-9622(23)01111-8.

Negbenebor NA et al (starts at 34:45). Nonmelanoma skin cancer in the setting of erosive pustular dermatosis of the scalp: A case series and comment on management implications. Dermatol Ther. 2022 Jul;35(7):e15584. doi: 10.1111/dth.15584. Epub 2022 May 28.

Sarkis A et al (starts at 41:54). Folliculitis Decalvans in women: a retrospective multicenter study of 150 patients. J Eur Acad Dermatol Venereol. 2023 Aug 18.

Vañó-Galván S et al (starts at 43:39). Folliculitis decalvans: a multicentre review of 82 patients. J Eur Acad Dermatol Venereol. 2015 Sep;29(9):1750-7.

Season 5, Episode 4 (Switching JAK Inhibitors, Ritlecitinib in Adolescents, VTE Risk in AT/AU, Habit Replacement Therapy in TTM) Aug 14, 2023

Show notes

STUDIES REFERENCE IN THE EPISODE

SWITCHING FROM TOFACITINIB TO BARICITINIB

Kazmi A et al (starts at 12:33). Switching between tofacitinib and baricitinib in alopecia areata: A review of clinical response. J Am Acad Dermatol. 2023 Apr 4;S0190-9622(23)00532-7.

RITLECITINIB IN ADOLESCENTS

Hordinsky M et al (starts at 21:31). Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double-blind, placebo-controlled trial. Pediatr Dermatol. 2023 Jul 17.

RISK OF INFECTIONS, CANCER, HEART DISEASE AND BLOOD CLOTS IN AT/AU

George P et al (starts at 36:08). Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database., Dermatol Ther (Heidelb). 2023 Aug; 13(8): 1733–1746.

Schneeweiss MC et al (starts at 37:36). Incidence of Venous Thromboembolism in Patients With Dermatologist-Diagnosed Chronic Inflammatory Skin Diseases. JAMA Dermatol. 2021 Jul 1;157(7):805-816.

MARKERS OF VENOUS THROMBOEMBOLISM IN ALOPECIA AREATA

Sudnik W et al (starts at 57:40) . The role of selectins in alopecia areata. Postepy Dermatol Alergol. 2015 Feb;32(1):27-32.

Shakoei S et al (starts at 58:23). Coagulation status in patients with alopecia areata: a cross-sectional study. Ital J Dermatol Venerol. 2021 Oct;156(5):588-592.

Waśkiel-Burnat A et al (starts at 59:30). Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There Anything to Worry about? Dermatol Ther (Heidelb). 2023 Aug;13(8):1847-1855.

HABIT REPLACEMENT THERAPY FOR TRICHOTILLOMANIA

Moritz S et al (starts at 1:04:34). Self-Help Habit Replacement in Individuals With Body-Focused Repetitive Behaviors: A Proof-of-Concept Randomized Clinical Trial. JAMA Dermatol. 2023 Jul 19;e232167.

LINK TO VIDEO on HRT DEMONSTRATION https://clinical-neuropsychology.de/habit-replacement-en/#sthash.J6iQiYRi.dpuf

Season 5, Episode 3 (Ranking of Finasteride and Minoxidil Protocols for FPHL, Follow up to New York Times Aug 2022 Article, Periorbital Edema from Oral Minoxidil, TE from Anticonvulsant Medications) Aug 08, 2023

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Season 5, Episode 2 (CVG secondary to Psoriasis, Hair Loss from Temporal Lifts, Oral minoxidil Lung Disease, PTSD & Autoimmunity, Laser Hair Removal & Behcet’s) Jul 25, 2023

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NON SCARRING ALOPECIA AFTER HYALURONIC ACID TEMPORAL LIFTING TECHNIQUES

Landau M et al (starts at 9:05). Nonscarring alopecia after temporal lifting technique with dermal fillers. JAAD Case Rep. 2023 May 12;37:30-34

Coimbra D.D., and de Oliveira B.S (starts at 10:17). Supra-auricular lifting with fillers: new technique. J Cosmet Dermatol. 2016;8(4):328–335.

CUTIS VERTICES GYRATA DUE TO PSORIASIS

Garcia-Rodriquez V et al (starts at 25:19). Cutis verticis gyrata secondary to scalp psoriasis. Int J Dermatol. 2023 Jun 4.

ORAL MINOXIDIL ASSOCIATED HYPERSENSITIVITY PNEUMONITIS

Takekosh D et al (starts at 32:35). Minoxidil-induced lung disease, masquerading as hypersensitivity pneumonitis. Respir Med Case Rep. 2023 Apr 29;43:101861.

PTSD AND AUTOIMMUNE DISEASE

Hsu TW et al (starts at 43:40). Risk of autoimmune diseases after post-traumatic stress disorder: A nationwide cohort study. Eur Arch Psychiatry Clin Neurosci. 2023 Jun 15.

Song H et al (starts at 49:18). Association of Stress-Related Disorders With Subsequent Autoimmune Disease. JAMA. 2018 Jun 19;319(23):2388-2400.

Dai Y-X et al (starts at 51:00). Posttraumatic Stress Disorder and the Associated Risk of Autoimmune Skin Diseases: A Nationwide Population-Based Cohort Study. Psychosom Med. 2021 Apr 1;83(3):212-217.

PATHERGY IN PATIENTS WITH BEHCET’S DISEASE RECEIVIGING LASER HAIR REMOVAL R

Nicolau et al (starts at 53:07). Pathergy-like reaction induced by laser hair removal in a patient with Behçet disease. Reumatismo. 2023 Jul 17;75(2).

Van der Ree-Pellikaan C et al (starts at 1:01:48). Oral ulcerations after placement of orthodontic braces and skin pustules after laser hair removal: novel inducers of pathergy reactions in new-onset Behçet's disease. BMJ Case Rep. 2016 Mar 7;2016:bcr2014209208. doi: 10.1136/bcr-2014-209208.

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