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    Health & Fitness

    Emergency Medical Minute

    Our near daily podcasts move quickly to reflect current events, are inspired by real patient care, and speak to the true nature of what it’s like to work in the Emergency Room or Pre-Hospital Setting. Each medical minute is recorded in a real emergency department, by the emergency physician or clinical pharmacist on duty – the ER is our studio and everything is live.

    Advertise

    Copyright: © Copyright Emergency Medical Minute 2019

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    Latest Episodes:
    COVID-19 Digest: Hydroxychloroquine Update (Recorded 4/3/20) Apr 04, 2020
    Show notes

    In our coverage of COVID-19 this week, we've investigated the shakey evidence for NSAID use making COVID worse, heard first-hand accounts from ED clinicians with COVID, and looked at the status of testing in the United States. Before capping our week of coverage off, we wanted to analyze some of the most recent literature on clinical interventions for COVID, particularly the recently FDA approved hydroxychloroquine.

    Host: Elizabeth Esty, MD

    Research By: Elizabeth Esty and Nathan Novotny

    Sound Editing By: Stephen Bahmani

    References

    1. Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020;30(3):269-271. doi:10.1038/s41422-020-0282-0
    2. Gautret P, Lagier J-C, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. March 2020:105949. doi:10.1016/j.ijantimicag.2020.105949
    3. Molina JM, Delaugerre C, Goff JL, et al. No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection. Médecine et Maladies Infectieuses. March 2020. doi:10.1016/j.medmal.2020.03.006
    4. Chen Z, Hu J, Zhang Z, et al. Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. medRxiv. March 2020:2020.03.22.20040758. doi:10.1101/2020.03.22.20040758

    COVID-19 in the United States: Where are the tests? Apr 02, 2020
    Show notes

    A dive into how the United States responded to an emerging pandemic and the pitfalls along the way that led to stalled testing capacity across the country before community transmission was confirmed. Hear what led us to our current situation, what continues to be an issue and new technologies on the horizon as well as how the rest of the world has responded.

    Host: Elizabeth Esty, MD

    Research By: Mason Tuttle

    Sound Editing By: Stephen Bahmani

    References:

    1. Shear M, Goodnough A, Kaplan S, Fink S, Thomas K, Weiland N. The Lost Month: How a Failure to Test Blinded the U.S. to Covid-19. The New York Times. https://www.nytimes.com/2020/03/28/us/testing-coronavirus-pandemic.html?smid=nytcore-ios-share. Published March 28, 2020.
    2. Topol E. US Betrays Healthcare Workers in Coronavirus Disaster. MedScape. https://www.medscape.com/viewarticle/927811. Published March 30, 2020.
    3. Abbott. DETECT COVID-19 IN AS LITTLE AS 5 MINUTES. https://www.abbott.com/corpnewsroom/product-and-innovation/detect-covid-19-in-as-little-as-5-minutes.html. Published March 27, 2020.
    4. Abdelmalek M, David E, Margolin J. Why coronavirus antibody testing in one Colorado town could provide a way forward. ABC News. https://abcnews.go.com/Health/antibody-testing-colorado-town-provide-forward/story?id=69856623. Published March 28, 2020.
    5. Kuznia R, Devine C, Griffin D. Severe shortages of swabs and other supplies hamper coronavirus testing. CNN. https://www.cnn.com/2020/03/18/us/coronovirus-testing-supply-shortages-invs/index.html. Published March 18, 2020.
    6. Judd D, Zaslav A, Diaz D. America is ramping up Covid-19 testing, but a shortage of basic supplies is limiting capabilities. CNN. https://www.cnn.com/2020/03/28/politics/coronavirus-swabs-supplies-shortage-states/index.html. Published March 28, 2020.
    7. Haug G. "A game changer": FDA authorizes Abbott Labs' portable, 5-minute coronavirus test the size of a toaster. USA Today. https://www.usatoday.com/story/news/health/2020/03/28/coronavirus-fda-authorizes-abbott-labs-fast-portable-covid-test/2932766001/. Published March 28, 2020.
    8. Hasell J, Roser M, Ortiz-Ospina E. Data on COVID-19 testing. Our World In Data. https://ourworldindata.org/covid-testing. Published March 28, 2020.
    9. Hale T. Iceland's Prolific COVID-19 Testing Is Telling Us A Lot About The Outbreak. IFLScience! https://www.iflscience.com/health-and-medicine/icelands-prolific-covid19-testing-is-telling-us-a-lot-about-the-outbreak/. Published March 27, 2020.

    Husband & Wife, Both ER Clinicians, Share Their Experience Having COVID-19 Apr 01, 2020
    Show notes

    Long time friends of EMM, Aaron and Bree, share their experiences on the frontlines in the ED, coping with COVID, managing anxiety and quarantining with their family.


    COVID-19 Digest: Do NSAIDs Make COVID-19 More Severe? (Recorded 3/30/20, 18:00 MST) Mar 31, 2020
    Show notes

    In the past two weeks, warnings, questions, and misinformation concerning COVID-19 and NSAID use have been spreading...no pun intended..virally. The pace of this evolving pandemic and the equally quick pace of the news and social media news cycle have meant that information and misinformation travel equally fast. Today we bring to you the story of how a letter in The Lancet led to a world of confusion.

    Host: Elizabeth Esty, MD

    Research By: Elizabeth Esty & Nathan Novotny

    Sound Editing By: Stephen Bahmani

    Time Stamps:

    0:00 - COVID-19 Statistics

    2:55 - The Lancet Letter: What Started the Rumor

    4:10 - ACE Inhibitors & ARB's

    5:00 - What The Lancet Letter Got Wrong

    6:25 - Treatment of HTN and DM in China vs. the U.S.

    9:13 - Do ACE Inhibitors Actually Increase ACE-2 Expression?

    11:00 - The French Ministry of Health and Their Warning About NSAIDs

    14:09 - Misinformation in the Age of COVID-19

    15:09 - Potential Harms of Tylenol Use

    16:11 - The Need for High-Quality Science to Overcome COVID-19

    References:

    1. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The Lancet Respiratory Medicine. March 2020:S2213260020301168. doi:10.1016/S2213-2600(20)30116-8
    2. Kane S. Ibuprofen - Drug Usage Statistics, ClinCalc DrugStats Database. ClinCalc DrugStats Database. https://clincalc.com/DrugStats/Drugs/Ibuprofen. Published December 23, 2019. Accessed March 30, 2020.
    3. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. March 2020. doi:10.1016/j.cell.2020.02.052
    4. Lu J, Lu Y, Wang X, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project). The Lancet. 2017;390(10112):2549-2558. doi:10.1016/S0140-6736(17)32478-9
    5. Wang Zengwu, Chen Zuo, Zhang Linfeng, et al. Status of Hypertension in China. Circulation. 2018;137(22):2344-2356. doi:10.1161/CIRCULATIONAHA.117.032380
    6. Hu C, Jia W. Diabetes in China: Epidemiology and Genetic Risk Factors and Their Clinical Utility in Personalized Medication. Diabetes. 2018;67(1):3-11. doi:10.2337/dbi17-0013
    7. Yuan H, Li X, Wan G, et al. Type 2 diabetes epidemic in East Asia: a 35-year systematic trend analysis. Oncotarget. 2018;9(6). doi:10.18632/oncotarget.22961
    8. Woo KS, Nicholls MG. High prevalence of persistent cough with angiotensin converting enzyme inhibitors in Chinese. Br J Clin Pharmacol. 1995;40(2):141-144.
    9. Chen X, Hu W, Ling J, et al. Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients. medRxiv. March 2020:2020.03.22.20040774. doi:10.1101/2020.03.22.20040774
    10. Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade. NEF. March 2020:1-9. doi:10.1159/000507305
    11. Qiao Y, Shin J-I, Chen TK, et al. Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate. JAMA Intern Med. March 2020. doi:10.1001/jamainternmed.2020.0193
    12. The Local. UPDATE - Coronavirus: French health minister and WHO issue warning over taking anti-inflammatories. https://www.thelocal.fr/20200314/coronavirus-french-health-minister-issues-warning-over-anti-flammatories. Published March 14, 2020. Accessed March 30, 2020.
    13. ScienceAlert. Updated: WHO Now Doesn't Recommend Avoiding Ibuprofen For COVID-19 Symptoms. https://www.sciencealert.com/who-recommends-to-avoid-taking-ibuprofen-for-covid-19-symptoms. Accessed March 30, 2020.
    14. European Medicines Agency. Coronavirus disease (COVID-19). https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19#advice-on-using-non-steroidal-anti-inflammatory-medicines-such-as-ibuprofen--section. Published March 18, 2020.
    15. U.S. Food and Drug Administration. FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19. https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19. Published March 19, 2020.
    16. BBC Reality Check team and BBC Monitoring. Coronavirus and ibuprofen: Separating fact from fiction. BBC News. https://www.bbc.com/news/51929628. Published March 17, 2020.
    17. Mosbergen D. Tylenol Overdose Risk Is Staggering; Acetaminophen Safeguards Remain Insufficient: Report. HuffPost. https://www.huffpost.com/entry/tylenol-overdose_n_3976991. Published September 24, 2013.

    Podcast 552: PE Management and Risk Stratification Mar 30, 2020
    Show notes

    Contributor: Dylan Luyten, MD

    Educational Pearls:

    • After you diagnose a pulmonary embolism (PE) via CT or VQ scan, we need to categorize the PE as massive, sub-massive, or just PE to dictate treatment.
    • Massive PE: shock with hypotension due to an embolism, and the treatment of choice is thrombolysis with IV tPA with anticoagulation after lysis. Catheter thrombolysis is not used in the hemodynamically unstable patient but can be done after they are stable.
    • Sub-massive: signs of right heart strain/failure but hemodynamically stable. This can be EKG changes, positive biomarkers, or imaging findings. These patients can be treated with IV heparin as there may benefit from catheter directed thrombolysis which has been shown to lead to better functional outcomes.
    • Everything else can be stratified to determine whether inpatient even outpatient treatment is necessary
    • Pulmonary Embolism Severity Index (PESI) or Hestia criteria and can help determine if the patient is better suited for in or outpatient management.
    • Non massive or sub-massive PEs are treated with heparin/Lovenox bridged to Warfarin, a factor Xa inhibitor (ex. Xarelto), or direct oral anticoagulants (DOAC).

    Editor's note: intravenous heparin is preferable to other anticoagulants when considering interventional radiology as it can be shut off and/or reversed if necessary prior to procedure

    References

    1. Sista, A. et al. Stratification, Imaging, and Management of Acute Massive and Submassive Pulmonary Embolism. 2017 Jul;284(1):5-24

    2. Aujesky D, Obrosky DS, Stone RA, Auble TE, Perrier A, Cornuz J, Roy PM, Fine MJ. Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med. 2005 Oct 15;172(8):1041-6

    3. Jimenez, D. et al. Risk stratification of patients with acute symptomatic pulmonary embolism. Intern Emerg Med. 2016 Feb;11(1):11-8.

    Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD


    COVID-19 Digest: If You've Had COVID-19, Can You Get it Again? / Convalescent Serum (Recorded 3/26/20, 18:00 MST) Mar 27, 2020
    Show notes

    Host: Elizabeth Esty, MD

    Research By: Elizabeth Esty and Nathan Novotny

    References:

    1. Osumi M. Questions raised over COVID-19 reinfection after Japanese woman develops illness again. The Japan Times. https://www.japantimes.co.jp/news/2020/02/28/national/coronavirus-reinfection/#.Xn4coZNKhQI. Published February 28, 2020.
    2. Bao L, Deng W, Gao H, et al. Reinfection could not occur in SARS-CoV-2 infected rhesus macaques. bioRxiv. March 2020:2020.03.13.990226. doi:10.1101/2020.03.13.990226
    3. Steinbuch Y. Doctor asks recovered coronavirus patients to be tested for antibodies. New York Post. https://nypost.com/2020/03/26/doctor-asks-recovered-coronavirus-patients-to-be-tested-for-antibodies/. Published March 26, 2020.
    4. Casadevall A. How a Boy's Blood Stopped an Outbreak. The Wall Street Journal. https://www.wsj.com/articles/how-a-boys-blood-stopped-an-outbreak-11582847330. Published February 27, 2020.
    5. U.S. Food and Drug Administration. Investigational COVID-19 Convalescent Plasma - Emergency INDs.https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds. Published March 24, 2020.
    6. Carmichael T. Takeda Pharmaceutical Announces a Plasma-Derived Coronavirus Therapy. Nasdaq. https://www.nasdaq.com/articles/takeda-pharmaceutical-announces-a-plasma-derived-coronavirus-therapy-2020-03-04. Published March 4, 2020.
    7. Maxmen A. How blood from coronavirus survivors might save lives. Nature. March 2020. https://www.nature.com/articles/d41586-020-00895-8.
    8. Amanat F, Nguyen T, Chromikova V, et al. A serological assay to detect SARS-CoV-2 seroconversion in humans. medRxiv. March 2020:2020.03.17.20037713. doi:10.1101/2020.03.17.20037713
    9. Steinbuch Y. Mount Sinai researchers develop test for coronavirus antibodies. New York Post. https://nypost.com/2020/03/24/mount-sinai-researchers-develop-test-for-coronavirus-antibodies/. Published March 24, 2020.

    ER Doc Infected with COVID-19 Shares Experience Mar 27, 2020
    Show notes

    Recorded 3/26/20


    COVID-19: Hydroxychloroquine & Azithromycin / Anosmia / The Aerosolized vs. Droplet Debate (Recorded 3/24/20, 18:00 MST) Mar 25, 2020
    Show notes

    The circumstances surrounding the COVID-19 virus are quickly evolving and that means that EMM will have to as well. For the foreseeable future, EMM will be releasing COVID-19 updates. In this series, we will report the most recent statistics, summarize the newest literature and answer YOUR burning questions. Submit your questions through comments on this post or through private messages on any of our social media platforms.

    Host: Elizabeth Esty, MD

    Research By: Elizabeth Esty, Jackson Roos, Nathan Novotny & Mason Tuttle

    Time Stamps:

    0:00 - COVID-19 by the numbers

    2:50 - Hydroxychloroquine and Azithromycin

    6:05 - Ongoing Anti-Viral Therapy Research

    7:47 - Anosmia

    9:31 - Viability of COVID-19 Aerosolized vs. on Surfaces

    10:49 - Listener Questions

    References:

    [1] The Center for Systems Science and Engineering (CSSE) at Johns Hopkins University Interactive Map

    [2] Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID‐19: results of an open‐label nonrandomized clinical trial. International Journal of Antimicrobial Agents – In Press 17 March 2020 –DOI : 10.1016/j.ijantimicag.2020.105949

    [3] Belhadi D, Peiffer-Smadja N, Yazdanpanah Y, Mentré F, Laouénan C. A brief review of antiviral drugs evaluated in registered clinical trials for COVID-19. medRxiv. March 2020:2020.03.18.20038190.doi:10.1101/2020.03.18.20038190

    [4] Hopkins C, Kumar N, ENT UK at The Royal College of Surgeons of England. Loss of sense of smell as marker of COVID-19 infection. https://www.entuk.org/sites/default/files/files/Loss%20of%20sense%20of%20smell%20as%20marker%20of%20COVID.pdf.


    Podcast 551: PPIs are Not Benign Mar 23, 2020
    Show notes

    Contributor: Don Stader, MD

    Educational Pearls:

    • PPIs (Proton pump inhibitors) reduce stomach acid levels and are commonly prescribed in patients with GERD or peptic ulcer disease
    • Stopping a PPI after sustained use for a month or longer can lead to withdrawal - causing a rebound indigestion or reflux due to a surge in acid production
    • Long term PPI use has noteworthy side effects including increased incidence of bacterial GI infections and pneumonia
    • Be cautious in prescribing a PPI for over 2 weeks. If continued indigestion control is needed, transition to a H2 blocker or OTC antacids if prolonged treatment is needed.

    References

    1)Haastrup PF, Thompson W, Søndergaard J, Jarbøl DE (2018) Side effects of long-term proton pump inhibitor use: a review. Basic Clin Pharmacol Toxicol 123(2):114–121. https://doi.org/10.1111/bcpt.13023 Review

    2) Helgadottir, H.; Bjornsson, E.S. Problems Associated with Deprescribing of Proton Pump Inhibitors. Int. J. Mol. Sci. 2019, 20, 5469.

    Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD


    On the Streets #3: COVID-19 Mar 19, 2020
    Show notes

    In this special edition of our On the Streets podcast, we discuss COVID-19 as well as what first responders and emergency providers need to know to keep themselves and their patients safe during this pandemic.


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