Discovery

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Knowing Pain Jan 29, 2018

Show notes

Scientists reveal why we feel pain and the consequences of life without pain. One way to understand the experience of pain is to look at unusual situations which give clues to our everyday agony.

Phantom limb pain was described in ancient times but only after WWI did it gain acceptance in modern medicine. For those living with it, it can be a painful reminder of a lost limb. New studies are now unravelling why the brain generates this often unpleasant experience and how the messages can be used positively.

Its only since the 1980s that doctors agreed that babies are able to feel pain but we still don’t know how the developing brain processes information and how premature babies can be protected from the many invasive tests they have to go through. New research aims to provide appropriate pain relief that could have long term consequences.

Picture: Nerve cells, computer artwork, Credit: Science Photo Library

Seeing Pain Jan 22, 2018

Show notes

Mystery still surrounds the experience of pain. It is highly subjective but why do some people feel more pain than others and why does the brain appear to switch off under anaesthesia so we are unaware of the surgeon’s scalpel? Professor Irene Tracey uses brain scanners to ask if we can actually see pain in the brain. On air we hear for the first time the results of the latest research into diabetes and nerve pain. Promising new techniques means scientists are able to see regions in the brain which effectively turn up the pain in some people and not others.

Anaesthetics prevent pain during surgery but how the brain disengages is only just beginning to be understood, which could in the future lead to personalised doses of anaesthetics leading to faster recovery times.

Picture: Graphic of neurons firing in the of the neural network within the Brain, Credit: Science Photo Library

Humphry Davy Jan 15, 2018

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In Bristol in 1799, a young man started to experiment with newly discovered gases, looking for a cure for tuberculosis. Humphry Davy, aged 20, nearly killed himself inhaling carbon monoxide. Nitrous oxide was next. It was highly pleasurable, ‘particularly in the chest and extremities’ and he began to dance around his laboratory ‘like a madman’, before passing out. By day, he gave the gas to patients, carefully noting their reactions. In the evenings, he invited his friends over to have a laugh (with assistants on standby to revive them with oxygen, as needed). The Romantic poets, Robert Southey and Samuel Taylor Coleridge could barely contain their excitement. During one session, Davy noted that the gas numbed his toothache and suggested that it could perhaps be used during surgical operations. But it was another fifty years before nitrous oxide was used by doctors. Throughout the 20th century, it was widely used during dentistry and to numb the pain of childbirth. (Nitrous oxide is the gas in ‘gas and air’: the ‘air’ is oxygen) .And it still is today, but less so. (It’s a potent greenhouse gas that damages the ozone layer, it’s difficult to store and there are side-effects). But, just as medical use is diminishing, recreational use is on the rise. A new generation of pleasure seekers have started experimenting, just as Davy did, despite the associated risks of injuries caused by fainting and death by suffocation. Naomi Alderman tells how a gas that created ‘ecstatic lunatics’ came to be used as an anaesthetic, with help from biographer, Richard Holmes and anaesthetist, Kevin Fong.

Picture: Humphry Davy and Anaesthesia, Credit: Science Photo Library

Lise Meitner Jan 09, 2018

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Philip Ball reveals the dramatic tale of Lise Meitner, the humanitarian physicist of Jewish descent, who unlocked the science of the atom bomb after a terrifying escape from Hitler's Germany. One of the most brilliant nuclear scientists working in Germany her flight from terror cost Hitler’s regime dearly.

In the early 20th Century it was barely possible for women to work in science at all and yet Einstein once called Meitner Germany’s own Marie Curie. It was Meitner’s insight that began the nuclear age and her story remains ever relevant, as the threat of nuclear conflict lies once again over the world.

Philip Ball talks to historian Dr Patricia Fara about Lise Meitner and her research and to Patricia Lewis of the International Campaign to Abolish Nuclear Weapons or ICAN, based in Geneva, which this year was awarded the Nobel Peace prize for its work in trying to reverse nuclear proliferation, about Meitner’s legacy today.

Picture: Lise Meitner, Credit: Central Press/Getty Images

The Day the Earth Moved Jan 01, 2018

Show notes

Roland Pease tells the story of how fifty years ago geologists finally became convinced that the earth’s crust is made up of shifting plates. The idea of mobile continents, continental drift, had been talked about, for example because it looked like Africa and South America had once been joined, and were now separated by the Atlantic. But given the solidity of rocks and the vastness of continents, that idea made no sense. Until plate tectonics, as it became known, gave it a scientific basis and rebuilt it into a mechanism that explained earthquakes, mountain belts, chains of volcanic islands and many other geological phenomena. Roland Pease talks to many of the key researchers in the story, now in their 70s and 80s, and finds out how their work transformed our understanding of the earth.

Picture: Tectonic plates of planet earth - map with names of major and minor plates, Credit: PeterHermesFurian

Presenter: Roland Pease

Maria Merian Dec 25, 2017

Show notes

Maria Merian was born in 1647. At the time of her birth, Shakespeare had been dead for 30 years; Galileo had only just stood trial for arguing that the Earth moved around the Sun. And yet, here in Germany, was a child who would become an important but oft-forgotten figure of science.

Aged 13, she mapped out metamorphosis, catching caterpillars from her garden and painting them in exquisite detail. At that point, most believed that caterpillars spontaneously generated from cabbages and maggots materialised from rotten meat. She later voyaged to Suriname in South America to pursue pupae further, discovering not just new species but also the conditions needed for their survival.

Some call her the first field ecologist; others admire her for her eloquent brushwork. However, her studies will help today’s biologists plot which insects lived where. These data are invaluable because this could help scientists predict what species will survive climate change.

Naomi Alderman discusses the life and legacy of Maria Merian with biologist and historian Kay Etheridge from Gettysburg College, Pennsylvania and biologist Kathy Willis from Kew Gardens.

Picture: Belly-ache bush (Jatropha gossypifolia) with metamorphosis of a giant sphinx moth (Cocytius antaeus), created by Maria Sibylla Merian and Joseph Mulder, Credit: GRI Digital Collections

Producer: Graihagh Jackson

Alcuin of York Dec 18, 2017

Show notes

The Dark Ages are often painted as an era of scholarly decline. The Western Roman Empire was on its way out, books were few and far between, and, if you believe the stereotype, mud-splattered peasants ran around in rags.

However, it was far more intellectually vibrant than you might imagine. Out of this era emerged a set of ‘problems to sharpen the young,’ including the famous river crossing puzzle that’s still taught in maths today. The presumed author of these riddles is Alcuin of York – ‘the most learned man in the world.’ And it was this monk and his puzzles that laid the foundations for a branch of mathematics called combinatorics – the thinking behind today’s computer coding and cryptography.

Philip Ball speaks to historian Mary Garrison from the University of York to learn of Alcuin's character and how he encouraged his students to learn for the sake of learning, as opposed to salvation. And University College London mathematician Hannah Fry shows Philip just how much of a role combinatorics plays in today’s world.

Picture: White horned goat chewing a cabbage leaf, Credit: Oxana Medvedeva

Producer: Graihagh Jackson

Cheating the Atmosphere Dec 11, 2017

Show notes

All countries are supposed to measure and report their greenhouse gas emissions but BBC environment correspondent, Matt McGrath, reveals there are gaping holes in national inventories. He uncovers serious failings in countries’ accounts of warming gases with many not reporting at all. There are disturbing signs that some banned warming chemicals, which are supposed to have been phased out completely, are once again on the rise. And evidence that worthless carbon credits are still being traded. Meanwhile scientists are growing increasingly frustrated by the refusal of countries to gather and share accurate data in the face of this planetary emergency

(Photo: The Jungfraujoch Air Monitoring Station in Switzerland. Credit: Jungfraujoch)

Better Brains Dec 04, 2017

Show notes

Every three seconds someone is diagnosed with dementia, and two thirds of the cases are Alzheimer’s Disease. As the global population ages, this is becoming an epidemic, and with no cures currently available for the collection of neurodegenerative conditions that include Alzheimer’s, Parkinson’s and Motor Neurone Disease the public and personal cost is escalating. Sue Broom reports on new efforts to find ways to stop the progress of these diseases for the first time, and to bring treatment for neurodegenerative conditions in line with those of cancer and heart disease.

Picture: Human head, Credit: Science Photo Library

Presenter: Sue Broom

What would happen if you fell into a black hole? Nov 21, 2017

Show notes

Two deadly cases today sent in by listeners to curiouscases@bbc.co.uk

The Dark Star "What's inside a black hole and could we fly a spaceship inside?" asks Jorge Luis Alvarez from Mexico City.

Astrophysicist Sheila Rowan explains how we know invisible black holes actually exist. Plus cosmologist Andrew Pontzen is on hand to help cook one up.

But which of our intrepid doctors will volunteer to fly into the heart of a black hole?

Kate Bush’s Sonic Weapon "It started while listening to the excellent Experiment IV by Kate Bush. The premise of the song is of a band who secretly work for the military to create a 'sound that could kill someone'. Is it scientifically possible to do this?" asks Paul Goodfield.

Hannah consults acoustic engineer Trevor Cox to ask if sonic weapons could kill. And Adam delves into subsonic frequencies with parapsychologist Chris French to investigate their spooky effects.

Plus the team investigates the Curious Case of the Embassy in Cuba – could a sonic weapon really be responsible for the wide-ranging symptoms reported by American diplomats in Havana?

You can send your scientific mysteries for the team to investigate to: curiouscases@bbc.co.uk

Picture: A computer-generated image of a rich star field with a Black Hole in front of it which distorts starlight into a brilliant ring around itself, Credit: BBC

Producer: Michelle Martin

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