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    Science

    Discovery

    Explorations in the world of science.

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    Copyright: © (C) BBC 2026

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    Latest Episodes:
    The Evidence: Drug-resistant superbugs Feb 26, 2022
    Show notes

    Today, Claudia Hammond and her panel of experts focus on what’s been called “the silent pandemic”, the threat to modern medicine of anti-microbial resistance or AMR.

    Infections are increasingly resistant to live-saving drugs like antibiotics and many believe the very future of modern medicine is hanging in the balance.

    In a series produced in collaboration with Wellcome Collection, this edition of The Evidence is recorded in front of a live audience in the Reading Room at Wellcome in London.

    Just last month, a new global study covering 204 countries and territories published in The Lancet reveals the scale of AMR to human health. The number of lives lost is double previous estimates.

    The latest data reveals 1.3 million deaths caused directly by resistant infections in just one year, 2019, and five million more deaths were linked with AMR.

    The figures are shocking, especially because one in every five deaths were in children, under five years old, with the highest number of deaths in Western Sub-Saharan Africa.

    But this is a pandemic that threatens everybody, wherever they live.

    Everly Macario a public health researcher from Chicago in the United States shares her family’s story: the death of their 18 month old son, Simon, to a drug-resistant strain of the bacterial infection MRSA (Methicillin-resistant Staphylococcus aureus). The loss of Simon spurred Everly to campaign against the mis-use of antibiotics, particularly in agriculture and farming, which contributes to the rise in AMR.

    Leaders in the global fight against AMR join Claudia to discuss the threat to human health and address the paradox that while AMR claims millions of lives, so many die each day because they can’t get access to basic, life-saving drugs like antibiotics.

    And Wellcome Collection’s Research Development Lead, Ross Macfarlane, delves into the archives and shares the warning from the inventor of the first antibiotic, penicillin, Alexander Fleming as he accepted his Nobel Prize in 1945, that mis-use would lead to resistance developing.

    The new super drug was destined to spawn the new super bug.

    Claudia’s guests include the UK Special Envoy on AMR, Professor Dame Sally Davies; the World Health Organisation’s Assistant Director General for Anti-Microbial Resistance, Dr Hanan Balkhy; Senior Research Manager for Drug Resistant Infections at Wellcome, Dr Janet Midega and the Director of ReAct Africa, Dr Mirfin Mpundu.

    Produced by: Fiona Hill, Anand Jagatia and Maria Simons Studio Engineers: Duncan Hannant and Emma Harth


    Tooth and claw: Spotted hyena Feb 21, 2022
    Show notes

    Cursed as a worthless scavenger and cast as villainous cowardly sidekicks in Disney’s The Lion King, the spotted hyena is one of the world’s most misunderstood of all predators. It may scavenge at night on a giant rubbish tip on the outskirts of Mekelle in Ethiopia, but it earns it’s top predator status when it takes down its prey in Kenya’s Masai Mara National Reserve. Adam Hart and guests polish up the spotted hyena’s tarnished reputation.

    Professor Kay Holekamp, a behavioural ecologist at Michigan State University, and Chinmay Sonawane, a biologist at Stanford University in California

    Picture: Spotted Hyena puppies and adult male with each other in Masat Mara, Credit: Manoj Shah/Getty Images Producer: Beth Eastwood Presenter: Professor Adam Hart


    Deep sea exploration Feb 14, 2022
    Show notes

    UCL oceanographer Helen Czerski explores life in the ocean depths with a panel of deep sea biologists. They take us to deep ocean coral gardens on sea mounts, to extraordinary hydrothermal vent ecosystems teeming with weird lifeforms fed by chemosynthetic microbes, to the remarkable biodiversity in the muds of the vast abyssal plains.

    Helen's guests are Adrian Glover of the Natural History Museum in London, Kerry Howell of Plymouth University and Alex Rogers, scientific director of REV Ocean.

    They discuss the dramatic revelations made by deep ocean explorers in just the last forty years, and the profound connections that the deep sea floor has with life at the Earth's surface. They also consider the threats to the ecosystems down there from seabed mining and climate change.

    Producer: Andrew Luck-Baker

    Picture: Black smoker hydrothermal vents, Credit: Science Photo Library


    A new space age? Feb 07, 2022
    Show notes

    In 2021, Captain James Kirk, aka William Shatner, popped into space for real for a couple of minutes, transported by space company Blue Origin's tourist rocket New Shepard. Elon Musk's Space X ferried more astronauts and supplies between Earth and the International Space Station, using its revolutionary reusable launchers and Dragon spacecraft. On Mars, the latest Nasa robot rover landed and released an autonomous helicopter - the first aircraft to fly on another planet.

    This year promises even more. Most significantly Nasa plans to launch the first mission of its Artemis programme. This will be an unmanned flight of its new deep space vehicle Orion to the Moon, propelled off the Earth by its new giant rocket, the Space Launch System. Artemis is the American space agency's project to return astronauts to the lunar surface and later establish moon bases. China also has a similar ambition.

    Are we at the beginning of a new space age and if so, how have we got here? When will we see boots on the Moon again? Could we even see the first people on Mars by the end of this decade?

    Dr Kevin Fong convenes a panel of astronautical minds to discuss the next decade or two of space exploration. He is joined by Dr Mike Barratt, one of Nasa's most senior astronauts and a medical doctor, based at the Johnson Space Center in Houston, Texas; Dr Anita Sengupta, research associate professor in Astronautical Engineering at the University of Southern California; Oliver Morton, briefings editor at The Economist and the author of Mapping Mars and The Moon.

    Producer: Andrew Luck-Baker

    Picture: Artist concept of the SLS Block 1 configuration, Credit: NASA/MSFC


    African science, African future Jan 31, 2022
    Show notes

    Professor Tom Kariuki has spent his career battling for science in Africa, both as a leading immunologist and as the former director of the Alliance for Accelerating Excellence in Science in Africa. Now, as the world comes to grips with the coronavirus pandemic and a global movement for social justice, could this prove an opportunity for the transformation of African science?

    Tom talks to leading scientists in Africa about the successes they have achieved as well as the profound challenges they face, from the complexities of international funding to keeping the lights on. He asks who African science belongs to and benefits, and what needs to happen if its future is to be prosperous.

    (Photo: A team of scientists in a lab. Credit: Getty Images)


    The Evidence: Africa, the pandemic and healthcare independence Jan 29, 2022
    Show notes

    In a special edition of The Evidence, Claudia Hammond and her panel of experts focus on Africa, on how the more than fifty countries on the continent, home to 1.3 billion people and the most youthful population in the world, have fared, two years into the pandemic.

    African scientists have been key players in the global response, sequencing variants of the virus and sharing this vital information with the world.

    But there’s been huge frustration and anger on the continent about the way Africa has, yet again, found itself at the back of the global queue for life-saving tests, treatments and vaccines.

    The sense that the global health system isn’t set up to deliver for Africa has prompted what’s been described as unprecedented solidarity, and galvanised calls for increased healthcare independence, self-sufficiency and a new public health order for the continent.

    This includes plans to manufacture the vaccines, medicines and tests that Africa needs to increase its health security in Africa for Africa.

    In The Evidence, the head of the World Health Organisation in Africa, Dr Matshidiso Moeti, tells Claudia it has been “extremely devastating” to watch history repeating itself (just like the HIV pandemic and the millions of African lives lost because they were unable to access life-saving antiretroviral medication) as international solidarity faltered and Africa struggled to access vital supplies.

    The Pasteur Institute in Dakar, Senegal (along with centres in South Africa and Rwanda) has a key role in pan-African plans for increased health sufficiency. Yellow Fever vaccines have long been made here but the plan is that later this year, mRNA vaccines for Covid-19 and eventually for other diseases like Lassa and Rift Valley fevers, will be manufactured at this and other sites.

    Institute head Professor Amadou Sall, a virologist and public health specialist says producing vaccines, medicines and tests will reduce the dependency of Africa on the global community and increase health security.

    Dr Yodi Alakija, co-chair of the African Union’s Vaccine Delivery Alliance and WHO Special Envoy to the Access to Covid Tools Accelerator, the ACT-Accelerator, says the pandemic has laid bare a failure of global political leadership, where a life in Lagos has been viewed as worth less than a life in London.

    The equity gaps in access to the tools needed to fight Covid-19, she says, must be closed, and there are hopes that a high level global conference, “Port to Arms: Africa Responds – Vaccine Equity, Delivery and Manufacturing”, in Abuja, Nigeria, in February, will lead to a renewed commitments to vaccinate the world and end this pandemic.

    Produced by: Fiona Hill and Maria Simons Studio Engineer: Donald McDonald and Tim Heffer


    The venomous vendetta Jan 24, 2022
    Show notes

    Whilst watching a documentary about some poisonous frogs, Curio Janni in Amsterdam, started to wonder what would happen if a frog licked itself or another frog of the same species. She asks Dr Adam Rutherford and Professor Hannah Fry to investigate whether an animal would react badly to a toxin it itself produces? In essence 'can a venomous snake kill itself by biting itself?'

    Of course the answer is complicated, but the sleuths know exactly who to ask.

    Steve Backshall, award-winning wildlife explorer, best known for his BBC series 'Deadly 60'. Author of 'Venom – Poisonous Creatures in the Natural World'. Steve has been bitten, stung and spat at by a plethora of venomous creatures during his career. He also studied the first known venomous newt - the sharp-ribbed newt - a creature that has sharpened ribs that when it's under attack, it will squeeze its body force those ribs out through its skin, coating them in venom, which is then delivered into the mouth of an attacker.

    Professor Nick Casewell, studies venomous snakes and their impact on humans. He works on treatments for snakebites at the Liverpool School of Hygiene and Tropical Medicine. Snakebites have a huge impact on communities in South Asia, Sub-Saharan Africa and South America. It's now been reinstated as one of the most serious neglected tropical diseases by the World Health Organisation. Traditional treatments - antivenins - can be expensive, difficult to access and don't always work - Nick is looking into alternative medicines to treat snakebite victims.

    Dr. Ronald Jenner is Principle Researcher in the Comparative Venomics group at the Natural History Museum's Life Sciences, Invertebrates Division and co-wrote the book ‘Venom -the secrets of nature's deadliest weapon.’ He explains the evolutionary arms race between venomous predators and their prey and poisonous prey and their predators. He explains how resistance to venom has evolved and how venom has evolved to be more or less powerful over time, answering another Curio - Scott Probert's question on the evolution of venom.

    Christie Wilcox wrote 'Venomous – How Earth’s Deadliest Creatures Mastered Biochemistry'. She studied the molecular basis of lionfish venom. Christie describes how venom and immunity to venom works at the molecular level.


    The slippery situation Jan 17, 2022
    Show notes

    'What is the slipperiest thing in the world?' asks 8 year old Evelyn? 'Why do my feet slip on a wet floor but when my feet are even slightly moist it's nearly impossible to put on a pair of socks without falling over and cursing the universe. What is going on here?' asks Evelyn's Dad, Sam. Hannah and Adam investigate the science of friction and lubrication - so called 'tribology' with the help of tribologists and mechanical engineers Professor Ashlie Martini from California University Merced and Professor Roger Lewis from the University of Sheffield. With their help Hannah and Adam find out why leaves on the line are so slippery, what happens to graphite in space and what is the slipperiest food. Professor of Materials, Mark Miodownik from University College London explains what's going on when friction stops two materials sliding past each other and wonders whether the slipperiest substance was actually discovered accidentally in a lab by scientists looking for something completely different. Also in the programme why the ability to reduce friction, even by minuscule amounts could have a huge impact for sustainability and reducing energy use.

    Producers: Jen Whyntie and Pamela Rutherford


    The painless heart Jan 10, 2022
    Show notes

    Dr Mitch Lomax is a sports scientist at the University of Portsmouth. She helps actual Olympic swimmers get faster. She explains how most of the muscles attached to our skeletons work: Tiny fibres use small-scale cellular energy, which, when all these fibres work in concert, turns into visible muscular movement. Mitch also explains how the dreaded Delayed Onset Muscle Soreness, or DOMS, can hit, taking a stair-wincing 48-72 hours to peak after exercise.

    But skeletal muscles turn out to be quite different to heart muscles, as consultant cardiologist Dr Rohin Francis explains. Heart cells are more efficient and don't get fatigued like skeletal muscle cells. They are extremely energetic and 'just want to beat'. He also explains that the sensory feedback from the heart muscles is different too. They have a different sort of nerve supply, with fewer sensory nerves, so that there is less chance of pain signals being sent to the brain.

    However, heart cells' incredible abilities are counterbalanced by one Achilles-like flaw: They cannot easily heal. Professor Sanjay Sinha is a British Heart Foundation (BHF) Senior Research Fellow and a Professor in Cardiovascular Regenerative Medicine at the University of Cambridge. His job is to fix broken hearts and he explains to Adam how new research into stem cells could be used to fix normally irreparable heart cells.

    Producer - Jennifer Whyntie and Fiona Roberts Presenters - Hannah Fry and Adam Rutherford


    The weirdness of water, Part 2 of 2 Jan 03, 2022
    Show notes

    “I don’t really understand why water has so many properties on different scales ranging from very large and cosmic to very small quantum and quarky - Could you help by zooming in and out on water to explain what is known about it? Asks Neil Morton in Stirling.

    “Why does boiling water sound different to cold water?’ asks Barbara Dyson in Brittany in France

    Ollie Gordon, in Christchurch in New Zealand, wants to know ‘why water is essential for all life as we know it?’

    And many more questions on the weirdness of water are tackled by super science sleuths Hannah and Adam helped by quantum physicist Professor Patricia Hunt, at the Victoria University in Wellington in New Zealand, science writer and author of ‘H2O – a biography of water’ Philip Ball and physicist and bubble expert in the Department of Mechanical Engineering at UCL, Dr Helen Czerski.

    Presenters: Hannah Fry & Adam Rutherford Producer: Fiona Roberts


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