Crush Step 1: The Ultimate USMLE Step 1 Review

An Update From Dr. O'Connell Sep 28, 2022

Dr. O'Connell gives an update about the Crush Step 1 book and as well as his new project, MedPrepToGo. Learn more at medpreptogo.com

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Chapter 17: Pulmonology (Part 2) Aug 27, 2020

Today's episode covers the second half of the Pulmonology chapter from Crush Step 1. Topics covered include:

- Respiratory Pathology

- Pharmacology

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Chapter 17: Pulmonology (Part 1) Aug 25, 2020

Today's episode covers the first half of the Pulmonology chapter from Crush Step 1. Topics covered include:

- Anatomy of the Respiratory System

- Respiratory Physiology

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Chapter 16: Reproductive Systems (Part 2) Aug 20, 2020

Today's episode is from the second half of the Reproductive Systems chapter of Crush Step 1. Topics covered include:

- Female Pathology

- Male Pathology

- Pharmacology

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Chapter 16: Reproductive Systems (Part 1) Aug 18, 2020

Today's episode is from the first half of the Reproductive Systems chapter of Crush Step 1. Topics covered include:

- Anatomy

Male and Female Reproductive Anatomy
Male and Female Gonadal Drainage

- Physiology

Hypothalamic-Pituitary-Gonadal Axis
Spermatogenesis
Male and Female Hormones
Female Physiology

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Chapter 15: Nephrology (Part 3) Aug 14, 2020

This episode is the last from the Nephrology chapter of Crush Step 1. Topics discussed include:

- Pathology (Cont.)

Tubular and Interstitial Disorders
Azotemia and Renal Failure
Urinary Tract Infections
Malignancies and Benign Tumors of the Urinary Tract
Congenital and Inherited Renal Disorders
Chronic Kidney Disease
Renal Osteodystrophy

- Pharmacology

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Chapter 15: Nephrology (Part 2) Aug 12, 2020

This episode contains the first part of the pathology section from the Nephrology chapter of Crush Step 1. Topics covered include:

- Hyponatremia and Hypernatremia

- Hypokalemia and Hyperkalemia

- Urinalysis and Urine Microscopy

- Kidney Stones

- Glomerular Diseases

- Nephrotic and Nephritic Syndromes

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Chapter 15: Nephrology (Part 1) Aug 10, 2020

This episode contains the first section of the Nephrology chapter from Crush Step 1, covering topics such as:

- Anatomy

- Physiology

Overview and Terminology
Glomerular Filtration Rate
Clearance and GFR
The Glomerulus and Filtration

- The Nephron and it's Segments

Proximal Tubule
Body Fluid Compartments and Maintenance
Other Endocrine Functions of the Kidney
pH Homeostasis and Acid-Base Disturbances

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Chapter 14: Psychiatry (Part 2) Aug 06, 2020

Today's episode includes the second half of the Psychiatry chapter from Crush Step 1, covering:

- Psychopathology (Cont.)

Bipolar Disorders
Anxiety Disorders
Obsessive-Compulsive Disorder
Stress Disorders
Malingering
Factitious Disorders
Somatoform Disorders
Personality Disorders
Dissociative Disorders
Eating Disorders
Gender Dysphoria
Disorders of Substance Abuse

- Medication Summary

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Chapter 14: Psychiatry (Part 1) Aug 04, 2020

Today's episode includes the first half of the Psychiatry chapter from Crush Step 1, covering:

- Psychology and Development (Theories of Learning & Miscellaneous Concepts)

- Psychopathology

Psychiatric Disorders of Children
Delirium v. Dementia
Schizophrenia & Similar Disorders
Depression

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Chapter 13: Neurology (Part 3) Jul 31, 2020

In the third and final part of the Neurology chapter from Crush Step 1, we finish covering pathology. We also discuss pharmacology.

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Chapter 13: Neurology (Part 2) Jul 29, 2020

In the second part of the Neurology chapter from Crush Step 1, we begin discussing pathology.

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Chapter 13: Neurology (Part 1) Jul 27, 2020

This episode covers the first part of the Neurology chapter from Crush Step 1, including topics such as:

- Anatomy and Physiology

Neurohistology
Sensory, Cutaneous, and Muscle Receptors
Neurotransmitters
Cerebral Perfusion Pressure (CPP)

- Anatomy [of the Brain]

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Chapter 12: Musculoskeletal/Rheumatology (Part 2) Jul 16, 2020

In this episode, we finish the Musculoskeletal/Rheumatology chapter by discussing:

- Disease of Bone

- Rheumatology Inflammatory Arthritis

- Seronegative

- Spondyloarthropathies

- Monoarticular Disease

- Pediatric Conditions

- Neoplasms of Bone

- Neoplasms of Soft Tissue

-Pharmacology

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Chapter 12: Musculoskeletal/Rheumatology (Part 1) Jul 14, 2020

In this episode, we begin the Musculoskeletal/Rheumatology chapter by covering:

- Upper and Lower Extremity Anatomy

- Brachial Plexus Syndromes

- Peripheral Nerve Lesions of the Upper and Lower Extremities

- Joints

- Pathology (Neuromuscular Junction Disorders, Muscular Dystrophy, and Mechanical Injuries)

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Chapter 11: Hematology and Oncology (Part 7) Jul 10, 2020

In the final episode from the Hematology and Oncology chapter of Crush Step 1, we discuss:

- Myeloproliferative Disorders

- Disorders of Heme Production

- Pharmacologic Treatment

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Chapter 11: Hematology and Oncology (Part 6) Jul 08, 2020

This episode is a continuation of the Hematology and Oncology chapter of Crush Step 1. Content covered includes:

- Lymphomas

- Histiocyte Disorders (Langerhans Cell Histiocytosis [LCH] and Histiocytosis X)

- Plasma Cell Disorders (Multiple Myeloma, Waldenström Macroglobulinemia [Lymphoplasmacytic Lymphoma], and Monoclonal Gammopathy of Undetermined Significance [MGUS])

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Chapter 11: Hematology and Oncology (Part 5) Jul 03, 2020

In this episode from the Hematology and Oncology chapter of Crush Step 1, we continue the discussion of pathology covering:

- Clotting Factor Deficiencies

- Hereditary Thrombosis Syndromes

- White Blood Cell Neoplastic Proliferation (Leukemias and Lymphomas)

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Chapter 11: Hematology and Oncology (Part 4) Jun 29, 2020

In this episode from the Hematology and Oncology chapter of Crush Step 1, we concluding our discussion of anemias by covering macrocytic anemias. Bleeding and thrombotic disorders are also discussed.

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Chapter 11: Hematology and Oncology (Part 3) Jun 19, 2020

In this episode from the Hematology and Oncology chapter of Crush Step 1, we continue discussing anemias, including normocytic and microcytic anemias. *This episode has been updated June 23, 2020.

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Chapter 11: Hematology and Oncology (Part 2) Jun 15, 2020

In this episode we continue the Hematology and Oncology chapter, covering topics such as:

- Platelet and Coagulation Tests

- Anticoagulant System

- Fibrinolytic System and Tests

- Pathology (Anemia)

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Chapter 11: Hematology and Oncology (Part 1) Jun 08, 2020

In this episode we begin the Hematology and Oncology chapter, covering topics such as:

- Anatomy (Blood: The Myeloid Lineage, Leukocytes, & The Lymphoid Lineage)

- Physiology (Blood Groups: ABO and Rh Systems & Hemostasis: The Coagulation Cascade)

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Chapter 10: Gastroenterology (Part 3) Jun 05, 2020

In this episode we wrap up the Gastroenterology chapter, covering topics such as:

- More Pathology (Hepatic neoplasms, disorders of bilirubin metabolism, and autoimmune disorders)

- Gallbladder and Pancreas

- Pediatric Gastroenterology and Hepatology

- Pharmacology (Antiemetics, antacids, cytoprotective agents, inflammatory bowel disease management, other agents)

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Chapter 10: Gastroenterology (Part 2) Jun 03, 2020

In this episode from the Gastroenterology chapter of Crush Step 1 we continue discussing Pathology, including:

- Inflammatory Bowel Disease

- Laboratory Tests

- Hepatic Pathology

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Chapter 10: Gastroenterology (Part 1) Jun 01, 2020

In this episode we begin the Gastroenterology chapter, covering topics such as:

- Anatomy (Digestive tract anatomy)

- Physiology (Gastric histology, histology of the intestine, gastrointestinal hormones, and saliva)

- Digestion and Absorption

- Pathology (Esophageal pathology, gastric and duodenal pathology, small bowel and colon)

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Chapter 9: Endocrinology (Part 3) May 29, 2020

In this episode we conclude the Endocrinology chapter, covering topics such as:

- Parathyroid Glands (anatomy/embryology/histology, overview of calcium homeostasis, laboratory testing and pitfalls, pathology causing increased calcium levels, and pathologic causes of decreased calcium levels)

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Chapter 9: Endocrinology (Part 2) May 27, 2020

In this episode we continue the Endocrinology chapter, covering topics such as:

- Adrenal Glands [Cortex and Medulla] (anatomy/embryology/histology, adrenal gland physiology, and pathology)

- Endocrine Pancreas (anatomy/embryology/histology and endocrine pancreas physiology)

- Diabetes (diagnosis of diabetes, chronic effects of hyperglycemia, acute emergencies in diabetes, islet cell tumors, and pharmacology of diabetes mellitus)

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Chapter 9: Endocrinology (Part 1) May 25, 2020

In this episode we begin the Endocrinology chapter, covering topics such as:

- Hormones (regulation, types of hormones, terminology of pathophysiology, and multiple endocrine neoplasia syndromes)

- Hypothalamus and Pituitary Gland (function overview, growth hormone, prolactin, and causes of anterior pituitary dysfunction)

- Thyroid Gland (anatomy/embryology/histology, thyroid hormone physiology, laboratory testing, pathology, and pharmacology)

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Chapter 8: Cardiology (Part 2) May 21, 2020

In this episode we cover the rest of the Cardiology chapter, including:

- Electrocardiography (including regulation of blood pressure)

- Pathology (Congenital Heart Disease, Atherosclerosis, Hypertension, Ischemic Heart Disease, Myocardial Infarction, Cardiomyopathies, Rheumatic Fever, Infective Endocarditis, Pericardial Disease, Vasculitides, as well as Cardiac and Vascular Tumors)

- Pharmacology (Vasopressors, Vasodilators, Sympatholytics, Diuretics, Antiarrhythmics, Adensine, and Digoxin)

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Chapter 8: Cardiology (Part 1) May 19, 2020

In the first part of the Cardiology chapter, we cover:

- Heart and Blood Vessels (Including anatomy of the heart as well as anatomy of the circulatory system)

- Physiology (Cardiovascular terminology and formulas)

- Electrophysiology (Including cardiac myocytes, Frank-Starling curve, cardiac cycle, and heart sounds & murmurs)

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Chapter 7: Pharmacology and Toxicology (Part 3) May 14, 2020

In the third and final episode covering the Pharmacology and Toxicology chapter, we discuss the following:

- Toxicology (Including common drugs, heavy metal toxicity, and environmental exposures)

- Ethanol, Methanol, and Ethylene Glycol

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Chapter 7: Pharmacology and Toxicology (Part 2) May 12, 2020

In the second part of the Pharmacology and Toxicology chapter, we discuss the following:

- Autonomic Nervous System and Signal Transduction

- Sympathetic Nervous System (Including signal transduction pathways)

- Parasympathetic Nervous System- Pharmacology (Including adrenergic and cholinergic pharmacology)

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Chapter 7: Pharmacology and Toxicology (Part 1) May 06, 2020

In the first part of the Pharmacology and Toxicology chapter we cover:

- Pharmacokinetics

- Pharmacodynamics

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Chapter 6: Immunology May 05, 2020

This episode covers the Immunology chapter of Crush Step 1, including topics such as:

- Lymphoid structures

- Innate versus adaptive immunity

- Cells of the immune system

- Major Histocompatibility Complex 1 & 2 - B cells, antibodies, and humoral immunity

- T cells, cell-mediated immunity, and immune system regulation

- Complement system

- Hypersensitivity response

- Transplantation immunology

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Chapter 5: Microbiology (Part 7) May 01, 2020

In the seventh and final part of the Microbiology chapter, we cover topics such as:

- Antimicrobials

- Antimycobacterial drugs

- Specific Antiviral Agents

- HIV Therapeutics/Highly Active Antiretroviral Therapy (HAART)

- Antifungals

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Chapter 5: Microbiology (Part 6) Apr 29, 2020

In the sixth part of the Microbiology chapter, we cover topics such as:

- Coronaviruses

- Rhabdoviruses

- Prion Diseases

- Fungi

- Superficial and Cutaneous Mycoses

- Subcutaneous Fungal Infections

- Systematic Mycoses

- Parasites

- Protozoa

- Helminths

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Chapter 5: Microbiology (Part 5) Apr 28, 2020

In the fifth part of the Microbiology chapter, we cover topics such as:

- More DNA Viruses

- Naked RNA Viruses

- Enveloped RNA Viruses

- Retroviruses

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Chapter 5: Microbiology (Part 4) Apr 24, 2020

In the fourth part of the Microbiology chapter, we cover topics such as:

- Gram-Positive Acid

- Fast Bacteria

- Gram-Positive Bacteria with No Cell Wall

- Introduction to Viruses

- DNA Viruses

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Chapter 5: Microbiology (Part 3) Apr 22, 2020

In the third part of the Microbiology chapter, we cover topics such as:

- Gram-Negative Nonenteric Robds

- Gram-Positive Branching Filamentous Bacteria

- Pleomorphic Bacteria

- Gram-Negative Spirals

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Chapter 5: Microbiology (Part 2) Apr 20, 2020

In the second part of the Microbiology chapter, we cover topics such as:

- Gram-Positive Rods

- Gram-Negative Enteric Rods

- Gram-Negative Nonenteric Rods

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Chapter 5: Microbiology (Part 1) Apr 15, 2020

In the first part of the Microbiology chapter, we cover topics such as:

- Introduction to Bacterial Structure

- Organization of the Rest of the Bacteriology Section

- Gram-Positive Cocci

- Gram-Negative Cocci

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Chapter 4: Embryology (Part 2) Mar 27, 2020

In the second and final part of the Embryology chapter, we review the following topics:

- Cardiac Embryology

- Formation of the Cardiac Loop

- Septation of the Heart

- Vascular Embryology- Neuroembryology

- Gastrointestinal Embryology

- Renal Embryology

- Reproductive Embryology

- Head and Neck Embryology

- Growth and Development

- Neonatal Medicine

- Developmental Milestones

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Chapter 4: Embryology (Part 1) Mar 25, 2020

In the first part of the Embryology chapter from Crush Step 1, we review topics such as:
- Description of Anatomy
- Early Embryology: The First Month
- From Fertilization to Implantation
- The Rule of Twos
- Gastrulation and the Ectoderm, Endoderm, and Mesoderm
- Neural Tube Closure and Beginning of Organogenesis
- Week Five and Beyond
- Organogenesis and Teratogenicity
- The “Fetal Period” of Organ Maturation
- Fetal Circulation and Erythropoiesis
- Structure of the Placenta and Umbilical Cord
- Changes to Fetal Circulation at Birth
- Fetal Erythropoiesis

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Chapter 3: Dermatology Mar 23, 2020

In this episode we cover the Dermatology chapter of Crush Step 1 including topics such as:
- Histology and Physiology
- Describing Lesions
- Pathology
- Common Dermatology Conditions
- Autoimmune Diseases
- Conditions of Pigmentation
- Neoplasms, Dysplasias, and Malignancies
- Skin Infections and Infestations
- Dermatologic Manifestations of Internal Disease

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Chapter 2: Biochemistry (Part 3) Mar 20, 2020

In the third and final episode covering the Biochemistry chapter from Crush Step 1, we review topics such as:
- Integration of Metabolism
- Vitamins
- Trace Elements
- Genetics- Patterns of Inheritance
- Basic Mendelian Inheritance
- Mitochondrial Inheritance
- Chromosomal Abnormalities
- Nondisjunction- Autosomal Trisomies
- Sex Chromosome Aneuploidy
- Trinucleotide Repeat Disorders
- Genetic Imprinting Diseases

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Chapter 2: Biochemistry (Part 2) Mar 18, 2020

In the second part of the Biochemistry chapter from Crush Step, we review topics such as:
- Heme Synthesis and Metabolism
- Nucleic Acid Structure and Function
- Purine Metabolism
- Pyrimidine Synthesis
- DNA Replication and Repair
- Carbohydrate Structure and Metabolism
- Glycolysis and Gluconeogenesis
- Pentose Phosphate Pathway
- TCA Cycle
- Electron Transport and Oxidative Phosphorylation
- Lipid Structure and Metabolism
- Sphingolipids and Sphingolipid Storage Diseases
- Eicosanoids

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Chapter 2: Biochemistry (Part 1) Mar 16, 2020

In the first part of the Biochemistry chapter from Crush Step, we review topics such as:
- Protein Structure and Function
- Amino Acid Structure
- Protein Structure
- Oxygen-Binding Proteins: Hemoglobin and Myoglobin
- Fibrous Proteins
- Enzymes
- Nitrogen Metabolism
- Disposal of Amino Acid Nitrogen
- Amino Acid Synthesis and Degradation
- Amino Acid Derivatives

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Chapter 1: Biostatistics Mar 09, 2020

In this episode we cover the Biostatistics chapter of Crush Step 1 including topics such as:
- Statistics for Diagnostic Tests
- Calculations of Risk Measures
- Statistical Tests and Significance
- Clinical Study Design
- Clinical Trials
- Medical Ethics
- Preventative Medicine and Health Care

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Crush Step 1: The Ultimate Step 1 Review Mar 02, 2020

The Crush Step 1 podcast features a totally free, audio optimized, complete narration of Crush Step 1: The Ultimate USMLE Step 1 Review by Ted O'Connell, Ryan Pedigo, and Thomas Blair. The podcast features up-to-date and easy to listen to high yield info on all the material tested on the exam with topics selected by a review board of current medical students and residents who scored in the 99th percentile on the USMLE Step 1. The Crush Step 1 podcast is the perfect companion for your dedicated prep time.

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