Critical Matters

Latest Episodes:

Corticosteroids in COVID-19 ARDS Sep 10, 2020

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In this episode of Critical Matters, we will take a deep dive into the topic of corticosteroids in COVID-19 ARDS. Our guest is Todd Rice, MD, an Associate Professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University. Dr. Rice is an accomplished physician-scientist focused on research in patients with sepsis, ARDS, and acute respiratory failure. He recently co-authored an editorial published in JAMA; “Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic.” Additional Resources: Corticosteroids in COVID-19 ARDS: https://bit.ly/3bFbFig PROSPERO Meta Analysis: https://bit.ly/3m69rgD RECOVERY Clinical Trial: https://bit.ly/35t59Ka REMAP-CAP Clinical Trial: https://bit.ly/3m2Hkz3 CODEX Clinical Trial: https://bit.ly/3bJQdbU CAPE-COVID Clinical Trial: https://bit.ly/3it8Xz7 Books Mentioned in this Episode: When Breath Becomes Air by Paul Kalanithi: https://amzn.to/2ZlVZeX

Towards Personalized Vasopressor Support Aug 27, 2020

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In this episode of Critical Matters, we will discuss hypotension and new data on Angiotensin II within the context of our path towards personalized vasopressor support. Our guest is Dr. Ashish K. Khanna. Dr. Khanna is an anesthesia and critical care practicing physician. He is Associate Professor, and Section Head for Research, in the Department of Anesthesiology, Section on Critical Care Medicine of the Wake Forest School of Medicine, in Winston-Salem, North Carolina. He is a prolific author and researcher and was the lead author of the ATHOS-3 study in the New England Journal of Medicine. The results of which led to the approval of Angiotensin II as a vasopressor for the treatment of refractory hypotension in adults with septic or other types of distributive shock. Links: The Relationship Between ICU Hypotension and In-Hospital Mortality and Morbidity in Septic Patients: https://bit.ly/2D1epJQ Association between Mean Arterial Pressure and Acute Kidney Injury and a Composite of Myocardial Injury and Mortality in Postoperative Critically Ill Patients: A Retrospective Cohort Analysis: https://bit.ly/2QuyStz Angiotensin II for the Treatment of Vasodilatory Shock (ATHOS-3 Trial): https://bit.ly/2G27hhB Survival After Shock Requiring High-Dose Vasopressor Therapy: https://bit.ly/2EkLm4P Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients: https://bit.ly/3jiKT1L Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock: https://bit.ly/2G1tZGB Additional Content Related to Angiotensin II: Angiotensin II for Vasodilatory Shock: 2019 Update: https://bit.ly/3hvVkyA Personalization of Vasopressor Therapy in the Treatment of Vasodilatory Shock: https://bit.ly/3hy7wyD

Racism In Healthcare Aug 13, 2020

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In this episode of Critical Matters, we will discuss racism in healthcare. Our guest is Dr. Gregory R. Johnson. Dr. Johnson is Chief Medical Officer of Hospital Medicine for Sound Physicians. In his role as CMO for Hospital Medicine, he has clinical leadership responsibility for over 200 hospital medicine programs and thousands of clinicians that care for millions of patients every year. Dr. Johnson is a thought leader within his field and a champion for diversity, inclusion, and belonging within medicine. Additional Resources: The Distribution of Suffering, Relief, and Greed in the Pandemic: https://bit.ly/30Tlzcl COVID-19 and African Americans: https://jamanetwork.com/journals/jama/fullarticle/2764789 Diagnosing and Treating Systemic Racism: https://bit.ly/30QGixp Unequal Treatment: https://bit.ly/3kEXTAd Tuskegee Syphilis Study: https://bit.ly/3fUU46q Books Mentioned in this Episode: Just Medicine: A Cure for Racial Inequality in American Health Care by Dayna B. Mathew: https://amzn.to/3amBTVU The Immortal Life of Henrietta Lacks by Rebecca Skloot: https://amzn.to/2POH3kd

COVID and ARDS - Back To Basics Jul 23, 2020

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In this episode of Critical Matters, we discuss the management of COVID induced ARDS. Our guest is Dr. Eddy Fan, an associate Professor in the Interdepartmental Division of Critical Care Medicine and the Institute of Health Policy, Management and Evaluation at the University of Toronto and a Staff Intensivist at the University Health Network/Mount Sinai Hospital. He is currently the Medical Director of the Extracorporeal Life Support Program at the Toronto General Hospital, and the Director of Critical Care Research at the University Health Network/Mount Sinai Hospital. During our conversation, we discuss phenotypes within ARDS, the best available evidence for the management of ARDS, and other topics. Additional Resources: COVID-19-Associated Acute Respiratory Distress Syndrome: Is a Different Approach to Management Warranted?: https://bit.ly/3fMkYOp American Thoraic Society - Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome: https://bit.ly/2CQTIju Management of COVID-19 Respiratory Distress: https://bit.ly/2WuwFCw Previous Episodes of Critical Matters on COVID-19 Induced ARDS/Respiratory Failure: - https://bit.ly/2OGWF8T - https://bit.ly/32yO2p7 Books Mentioned in this Episode: A Portrait of the Artist as a Young Man by James Joyce: https://amzn.to/2OJyiHM

Pregnancy, Critical Care, And COVID - 19 Jul 02, 2020

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In this episode of Critical Matters, we discuss pregnancy, critical care, and COVID-19. Our guest is Dr. Cesar Padilla. Dr. Padilla is an attending physician in the Department of Intensive Care and Resuscitation in the Cleveland Clinic in OHIO. He is a practicing anesthesia critical care physician with additional expertise and training in obstetric anesthesia. He is extremely interested in promoting better care of obstetrical patients requiring critical care and has worked in this area extensively from the clinical, educational, and research perspective. Additional Resources: Articles on Critical Care and Pregnancy by Dr. Padilla: - https://bit.ly/2BTHFkZ - https://bit.ly/2YKBrwH Development of a Comorbidity Index for Use in Obstetric Patients: https://bit.ly/38gtvq1 CDC COVID-19 and Pregnancy Resource Page: https://bit.ly/31v9XwH Articles by Dr. Padillas on KevinMD.com: https://bit.ly/31zIl9M Previous episodes on pregnancy and critical care: - https://bit.ly/2YPjld4 - https://bit.ly/38g5f7k Books Mentioned in this Episode: Twelve Rules for Life: An Antidote to Chaos by Jordan B. Peterson: https://amzn.to/2Zo8nu2

The Pause Jun 11, 2020

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In this episode of Critical Matters, we discuss challenges related to providing compassionate patient aligned care in the intensive care unit within the frame of COVID-19. We also explore “The Pause”, a simple yet innovative practice with the power to transform our practices. Our guest is Dr. Silvia Perez Protto, an anesthesia and critical care attending at the Cleveland Clinic. Dr. Perez Protto is a faculty member of the Department of Intensive Care and Resuscitation and is the Medical Director for the End of Life Center at the Cleveland Clinic. Additional Resources: Empathy: The Human Connection to Patient Care: https://bit.ly/3hiRWHk The Pause (for iPhone: https://apple.co/2zqzGei The Pause (for Android: https://bit.ly/3fislgd The Conversation Project: https://bit.ly/3cRjMaj New York Times - “An Incalculable Lost”: https://nyti.ms/2MOipyQ Books Mentioned in this Episode: When Breath Becomes Air by Paul Kalanithi: https://amzn.to/2YgjVPe Outliers by Malcolm Gladwell: https://amzn.to/3hdy3l3 The Tipping Point: How Little Things Can Make a Big Difference by Malcolm Gladwell: https://amzn.to/37hJJyC

AKI In COVID - 19 May 28, 2020

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In this episode of the Critical Matters, we will discuss acute kidney injury (AKI) in patients with COVID-19. Our guest is Dr. Claudio Ronco, a thought leader in the field of acute kidney injury and nephrology critical care. Dr. Ronco is professor of Nephrology at the University of Padua. Dr. Ronco is also Director of the Department of Nephrology Dialysis & Transplantation and of the International Renal Research Institute (IRRIV) at San Bortolo Hospital in Vicenza, Italy. Additional Resources: Acute Kidney Injury: https://bit.ly/3daKxaD Management of Acute Kidney Injury in Patients with COVID-19: https://bit.ly/3daKyLJ Extracorporeal Blood Purification and Organ Support in the Critically Ill Patient During COVID-19 Pandemic: Expert Review and Recommendation: https://bit.ly/3c6fxre Video - Cappuccino with Claudio Ronco: https://bit.ly/2B5X3dr Books Mentioned in this Episode: Carpediem by Claudio Ronco: https://amzn.to/3ekVMxm From Fish to Philosopher by Homer W. Smith: https://amzn.to/3c8j8F9

COVID - 19: Interrupting The VILI Vortex May 14, 2020

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In this episode of Critical Matters, we continue our exploration and discussion on respiratory support and mechanical ventilation with COVID-19. Our guest is Dr. John J. Marini, a thought leader in the field of critical care. Dr. Marini is Director of Academic Programs in Research and Education for the Department of Medicine of the Regions Hospital in St. Paul, Minnesota. In most of his research, he has positioned himself at the interface between basic physiology and clinical medicine to develop insights into advancing clinical practice. In this episode, he discusses evolving concepts related to ventilator-induced lung injury and how they apply to respiratory support in patients with COVID-19. Additional Resources: Management of COVID-19 Respiratory Distress: https://bit.ly/2WuwFCw Time Course of Evolving Ventilator-Induced Lung Injury: https://bit.ly/2YVyEkO Static and Dynamic Contributors to Ventilator-induced Lung Injury in Clinical Practice. Pressure, Energy, and Power: https://bit.ly/360Fmr5 Books Mentioned in this Episode: Nunn's Applied Respiratory Physiology by Andrew B. Lumb: https://amzn.to/2UQLeiX The Discoverers by DJ Boorstin: https://amzn.to/2yTnL8u Why Not Say it Clearly: A Guide to Scientific Writing by LS King.: https://amzn.to/2WV6tzI

COVID - 19 Ethics During A Pandemic Apr 23, 2020

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In this episode of Critical Matters, we discuss ethical issues related to the COVID-19 pandemic. Our guest is Arthur L. Caplan, Ph.D. Dr. Caplan is the director of the Division of Medical Ethics at New York University Langone Medical Center and School of Medicine. He is the author and editor of 35 books and 750 peer-reviewed articles. Dr. Caplan is a recognized thought leader and expert in the field of medical ethics. Additional Resources: WHO – Guidance to Managing Ethical Issues in Infectious Disease Outbreaks: https://bit.ly/3bwhqOe Ethics of Outbreaks Position Statement. Part 1: Therapies, Treatment Limitations, and Duty to Treat: https://bit.ly/2Vs8i7G Ethics of Outbreaks Position Statement. Part 2: Family-Centered Care: https://bit.ly/3cQngun Fair Allocation of Scarce Medical Resources in the Time of COVID-19: https://bit.ly/2VRX1fQ Books Mentioned in this Episode: Plato: Five Dialogues by Plato: https://amzn.to/3bum1Rf Benjamin Franklin: An American Life by W. Isaacson: https://amzn.to/2VOpGTg Poor Richard’s Almanac by B. Franklin: https://amzn.to/2XUQqnK

Mechanical Ventilation In COVID - 19 Apr 07, 2020

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On this episode of Critical Matters, we will focus on respiratory support and mechanical ventilation with COVID-19. Our guest is Dr. Luciano Gattinoni, a thought leader in the field of critical care. Dr. Gattinoni introduced the concept of lung rest by extracorporeal CO2 removal in acute respiratory failure. He pioneered the use of thoracic CT in ARDS, which culminated in the "baby lung", lung recruitability, and Mechanical Power concepts. His research is focused on the pathophysiology and treatment of acute respiratory failure, including prone positioning, sepsis and acid-based disorders. Dr. Gattinoni has published more than 400 research articles and reviews in peer-reviewed journals. Additional Resources: COVID-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome: https://bit.ly/3e2cNNw COVID-19 Pneumonia: Different Respiratory Treatment for Different Phenotypes?: https://bit.ly/2URaCFd Books Mentioned in this Episode: Siddharta by Herman Hess: https://amzn.to/3bXi6vP The Prince by Nicolo Machiaveli: https://amzn.to/2RjyOho Nunn's Applied Respiratory Physiology: https://amzn.to/2UQLeiX The Pathway for Oxygen by M.D. Edwald R. Weibel: https://amzn.to/2yKpNrf Clinical Physiology of Acid-Base and Electrolyte Disorders by Burton Rose and Theodore Post: https://amzn.to/3e2dDdh

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