Critical Care Reviews Podcast

IVIO Trial Nov 13, 2024

Rob Mac Sweeney discusses the IVIO trial with investigators Lars Wiuff Andersen and Mikael Fink Valentine from Aarhus, Denmark. The IVIO trial compared intraosseous with intravenous vascular access in adult patients suffering an out-of-hospital cardiac arrest. It was presented at the 2024 European Resuscitation Council congress in Athens and simultaneously published in the New England Journal of Medicine.

PARAMEDIC 3 Trial Nov 12, 2024

Rob Mac Sweeney discusses the PARAMEDIC 3 trial with it's investigators Keith Couple and Ranjit Lall from the University of Warwick, England. PARAMEDIC 3 compared intravenous with intraosseous vascular access in adult patients suffering cardiac arrest and requiring drug administration during ongoing resuscitation. It was presented at the European Resuscitation Council meeting in Athens on October 31st and simultaneously published in the New England Journal of Medicine.

B-FREE Trial Apr 07, 2024

Rob Mac Sweeney chats with Jessica Spence about the B-FREE trial, investigating benzodiazepine-free anaesthesia for the prevention of delirium in cardiac surgery

Beyond Platform Trials Panel Discussion Mar 13, 2024

Bala Venkatesh (Brisbane) hosts a panel discussion entitled "Beyond Platform Trials" at the Critical Care Reviews Meeting 2023. The panellists include Bronagh Blackwood (Belfast), Susan Rowell (Chicago), Fernando Zampieri (Edmonton), Marion Campbell (Aberdeen), David Harrison (London), Roger Lewis (Los Angeles), Derek Angus (Pittsburgh) & Kathy Rowan (London).

Causality Panel Discussion Mar 13, 2024

Kathy Rowan (London) hosts a fascinating panel discussion on causality at the Critical Care Reviews Meeting 2023. The panellists include Bronwen Connolly (Belfast), Ewan Goligher (Toronto), Flavia Machado (Sao Paulo), Kath Maitland (Kalifi), John Norrie (Edinburgh), Victoria Cornelius (London), Andrew Althouse (Pittsburgh) and Chris Seymour (Pittsburgh).

REMAP-CAP Trial Long Term Outcomes Mar 13, 2024

Dr Lisa Higgins (Melbourne) presents the long term outcomes of the REMAP-CAP domains at the Critical Care Reviews Meeting 2023. Prof Howard Bauchner (Boston) delivers an editorial. Prof Christopher Seymour (Pittsburgh) chairs the session.

AID-ICU Trial Mar 13, 2024

Nina Christine Andersen-Ranberg presents the AID-ICU trial, investigating haloperidol for the management of delirium in the ICU. Danny McAuley delivers an editorial. Anders Perner joins the discussion and the session is chaired by Paul Mouncey.

John Hinds Lecture 2023 Mar 13, 2024

Prof Flavia Machado (Sao Paulo) delivers the John Hinds Lecture at the Critical Care Reviews Meeting 2023, describing the story of BRICNET, the Brazilian Critical Care Trials Group. The session commences with Dr Chris Nutt remembering our friend, Dr John Hinds.

PROCOAG Trial Feb 05, 2024

You're listening to the audio version of the PROCOAG trial presentation from the Critical Care Reviews Meeting 2023. The PROCOAG trial investigated the efficacy and safety of early administration of 4-factor prothrombin complex concentrate in trauma patients at risk of massive transfusion. The trial is presented by Pierre Bouzat from Grenoble. Susan Rowell from Chicago, delivers the editorial. The session is chaired by Chris Seymour (Pittsburgh). PROCOAG was published in JAMA in March 2023.

TEAM Trial Feb 05, 2024

You're listening to the audio version of the TEAM trial presentation from the Critical Care Reviews Meeting 2023. The TEAM trial investigated early active mobilisation in critically ill mechanically ventilated patients. The trial is presented by Carol Hodgson from Melbourne. Darren Taichman from Philadelphia, delivers the editorial. The session is chaired by Paul Mouncey (Pittsburgh).

PILOT Trial Jan 26, 2024

Matthew Semler (Nashville, USA) presents the PILOT trial at the Critical care Reviews Meeting 2023, in Titanic Belfast. The PILOT trial compared low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Kath Maitland from Kigali, Kenya, delivers an independent editorial. The session is chaired by Chris Seymour from Pittsburgh, USA. PILOT was published in the New England Journal of Medicine on November 10th, 2022.

REMAP-CAP / LOVIT-COVID Vitamin C Trial Jan 16, 2024

Dr Francois Lamontagne joins Rob Mac Sweeney to discuss the harmonised REMAP-CAP / LOVIT-COVID vitamin C trial. The trial was presented at the European Society of Intensive Care Medicine annual congress and simultaneously published in the New England Journal of Medicine.

NICO Trial Dec 31, 2023

OXY-PICU Trial Presentation Dec 03, 2023

Mark Peters and Doug Gould (both London) present the results of the OXY-PICU trial, comparing conservative with liberal oxygenation targets (SpO2 88-92% vs >94%) in critically ill children receiving invasive mechanical ventilation. Luregn Schlapbach (Zurich) delivers an independent editorial. They are joined by Victoria Cornelius (London), Bronagh Blackwood (Belfast), & Matthew Semler (Nashville) for a panel discussion. The session is chaired by Howard Bauchner (Boston).

REMAP-CAP Statin Domain Oct 25, 2023

Scott Berry (Austin) and Danny McAuley (Belfast) join Rob Mac Sweeney to discuss the results of the statin domain of the REMAP-CAP trial, investigating 80mg once daily of simvastatin in critically ill patients with COVID-19.

UK-REBOA Trial Presentation Oct 12, 2023

Jan Jansen (Birmingham, USA) & Marion Campbell (Aberdeen) present the results of the UK-REBOA trial, investigating the use of REBOA in trauma patients with severe non-compressible torso haemorrhage. The editorial is delivered by John Holcomb (also from Birmingham, USA) and the session is chaired by Catriona Kelly from Dublin. The panel discussing the trial are Diana Cimpoesu (Ilsa, Romania), Caroline Leech (Coventry), Stephen Bernard (Melbourne) and Roger Lewis (Los Angeles).

CRYOSTAT-2 Trial Presentation Oct 12, 2023

Profs Nikki Curry (Oxford) and Karim Brohi (London) present the results of the CRYOSTAT-2 trial, evaluated early & empiric high-dose cryoprecipitate in patients with major traumatic haemorrhage. The editorial is delivered by Susan Rowell (Chicago) and the session is chaired by Phil Gillen from Belfast. The panel discussing the trial are Russell Gruen (Canberra), Caroline Leech (Coventry), John Holcomb (Birmingham, USA), Andrew Althouse (Pittsburgh) and co-investigator Simon Stanworth from Oxford.

CLOVERS Trial Sep 08, 2023

Prof Ivor Douglas (Denver, USA) presents the CLOVERS trial, comparing an early restrictive fluid strategy with an early liberal fluid strategy in adult patients with sepsis-induced hypotension. Prof Fernando Zampieri (Edmonton, Canada), delivers an editorial. The session is chaired by Dr Paul Mouncey (London, England).

PATCH-Trauma Trial Presentation Jul 27, 2023

Russell Gruen, Brian Burns and Stephen Bernard present the results of the PATCH-Trauma trial, investigating tranexamic acid in severe trauma. An independent editorial is delivered by Karim Brohi (London). Caroline Leech (Coventry) chairs a panel discussion consisting of Susan Rowell (Chicago), Carol Hodgson (Melbourne), John Holcomb (Birmingham, USA) and John Norrie (Edinburgh).

TAME Trial Presentation Jul 24, 2023

Glenn Eastwood presents the results of the TAME cardiac arrest trial, investigating mild hypercapnoea post cardiac arrest. He is joined by senior investigators Alistair Nichol (Dublin) and Stephen Bernard (Melbourne). An independent editorial is delivered by Lars Andersen (Aarhus). Darren Taichman (Philadelphia) chairs a panel discussion consisting of Flavia Machado (Sao paulo), Joyce Yeung (Birmingham, UK) and Andrew Althouse (Pittsburgh), as well as the other speakers.

DEVICE Trial Results Jul 06, 2023

Profs Matthew Prekker (Minneapolis) and Matthew Semler (Nashville) present the results of the DEVICE trial, comparing direct with video laryngoscopy for emergency intubation in the critically ill. Prof Ellen O'Sullivan (Dublin) delivers an editorial, followed by a panel discussion including Prof David Harrison (London), Dr Caroline Leech (Coventry), Dr Fiona Kelly (Bath) and Prof Alistair Nichol (Dublin). The session was chaired by Dr Catriona Kelly (Dublin).

These results were presented at the Critical Care Reviews Meeting 2023, held in Titanic Belfast on June 16th. The DEVICE trial was simultaneously published in the New England Journal of Medicine.

MERCY Trial Results Jun 29, 2023

Profs Giovanni Landoni and Giacomo Monti present the results of the MERCY trial, comparing bolus administration with continuous infusion of meropenem in critically ill patients with sepsis and septic shock. The results were presented at the Critical Care Reviews Meeting 2023, in Titanic Belfast. Prof Flavia Machado (Sao Paulo) delivers an editorial. The panel discussion incldues Profs Kathy Rowan (London), Victoria Cornelius (London), Ivor Douglas (Denver) and Ewan Goligher (Toronto). The session was chaired by Chris Nutt (Belfast).

SuDDICU Trial Presentation Oct 26, 2022

John Myburgh and Ian Seppelt (Sydney) present the results of the SuDDICU trial at the Critical Care Reviews Meeting 2022, in Titanic Belfast. SuDDICU investigates selective digestive decontamination in critically ill mechanically ventilated patients. Naomi Hammond (Sydney) follows with a presentation of a systematic review and meta analysis also on SDD. John Marshall (Toronto) delivers an editorial. Danny McAuley (Belfast), Bodil Steen Rasmussen (Aalborg) and Victoria Cornelius (London) join the presenters for a panel discussion. The session is chaired by Chris Seymour (Pittsburgh).

PILOT Trial Result Livestream Oct 25, 2022

Matthew Semler presents the results of the PILOT trial, comparing low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Paul Young delivers an editorial and Chris Nutt asks questions from the viewers. The expert panel discussion includes Victoria Cornelius, Angelique de Man, Bodil Steen Rasmussen and Gilles Capellier. The paper was simultaneously published in the New England Journal of Medicine.

Prague Out-of-Hospital Cardiac Arrest Study Oct 11, 2022

Prof Jan Belohlavek (Prague, Czech Republic) presents the Prague Out-of-Hospital Cardiac Arrest Study at the Critical care Reviews Meeting 2022. This study investigates the efficacy of an eCPR programme in patients with refractory out-of-hospital cardiac arrest. Dr Liz Wilcox (Toronto, Canada) follows with an editorial on the trial.

VAM-IHCA Trial Presentation at CCR22 Sep 18, 2022

Lars Andersen (Aarhus, Denmark) presents the VAM-IHCA trial on June 15th at the Critical Care Reviews Meeting 2022, in Titanic Belfast. The VAM-IHCA trial investigates the combination of vasopressin and methylprednisolone in in-hospital cardiac arrest. Chris Seymour (Pittsburgh, USA) delivers an editorial after the trial presentation. The session is chaired by Catriona Kelly (Dublin, Ireland).

TTM2 Trial Presentation at CCR22 Sep 01, 2022

RePHILL Trial Presentation at CCR22 Aug 21, 2022

Nick Crombie (Birmingham, England) presents the RePHILL trial, comparing pre-hospital administration of saline with blood products in patients with trauma-related haemorrhagic shock. Liz Wilcox (Toronto, Canada) delivers an editorial. The session is chaired by Catriona Kelly (Dublin, Ireland).

PREPARE II Trial Result Presentation Aug 03, 2022

Derek Russell (Birmingham, USA) and Jon Casey (Nashville, USA) presents the results of the PREPARE II trial, investigating fluid bolus therapy for the prevention of cardiovascular collapse during emergency intubation. Anthony Gordon (London, England) delivers an editorial, which is followed by a panel discussion including Lennie Derde (Utrecht, the Netherlands), Andrew Althouse (Pittsburgh, USA), Elizabeth Wilcox (Toronto, Canada) and Lars Andersen (Aarhous, Denmark). The session is chaired by Chris Seymour from the USA. PREPARE II was simultaneously published in JAMA.

CLASSIC Trial Results Presentation Jul 27, 2022

Dr Tine Sylvest Meyhoff (Copenhagen, Denmark) presents the results of the CLASSIC trial at the Critical Care Reviews Meeting 2022. Prof Katryn Maitland (Kalifi, Kenya) delivers an editorial, which is followed by a panel discussion including Prof David Harrison (London, England), Dr Lennie Derde (Utrecht, the Netherlands), Dr Jon Silversides (Belfast, Northern Ireland), and the chief investigator for CLASSIC, Prof Anders Perner (Copenhagen, Denmark). The session is chaired by Prof Bala Venkatesh from Brisbane, Australia.

FIRST-ABC (step up) Trial Result Presentation Jul 20, 2022

Drs Padmanabhan Ramnarayan and Paul Mouncey (both London) present the results of the FIRST-ABC trial, comparing high-flow nasal cannulae therapy with CPAP in acute ill children with respiratory failure, at the Critical Care Reviews Meeting 2022. Dr Srinivas Murthy (Vancouver) delivers an editorial, which is followed by a panel discussion including Profs Kathryn Maitland (Kalifi), John Marshall (Toronto) and Marion Campbell (Aberdeen). The session is chaired by Prof Howard Bauchner.

NITRIC Trial - Panel Discussion Jun 28, 2022

Rob Mac Sweeney (Belfast, Northern Ireland) hosts a panel discussion including Prof Paul Checchia (Houston, USA), Prof Wes Diddle (Washington DC, USA), Prof Ranjit Lall (Coventry, England), Prof Kathy Rowan (London, England), as well as the NITRIC trial chief investigator Luregn Schlapbach (Zurich, Switzerland) and editorialist Prof Mark Peters (London, England)

NITRIC Trial - Viewer's Questions Jun 28, 2022

Dr Bronwen Connolly asks cheif investigator Luregn Schlapbach questions from the viewers during the livestream of the NITRIC trial results

NITRIC Trial Editorial Jun 28, 2022

Prof Mark Peters, from Great Ormond Street Hospital, delivers an editorial on the NITRIC trial, investigating nitric oxide during cardiac surgery for children with congenital cardiac disease. The chief investigator for the trial Assoc Prof Luregn Schlapbach replies.

NITRIC Trial Results Jun 28, 2022

Assoc Prof Luregn Schlapbach (Zurich, Switzerland) presents the results of the NITRIC trial, investigating nitric oxide during cardiac surgery for children with congenital cardiac disease.

FIRST-ABC Trial Results - Panel Discussion Apr 10, 2022

Rob Mac Sweeney hosts a panel discussion on the results of the FIRST ABC trial, comparing HFNO with CPAP in recently extubated children. The panelists are Martha A.Q. Curley (Philadelphia), Christopher M. Horvat (Pittsburgh), Martin Kneyber (Groningen), and David Harrison (London). They are joined by Padmanabhan Ramnarayan (chief investigator), Alvin Richards-Belle (trial manager) and Adrienne Randolph (editorialist).

FIRST-ABC Trial Results - Viewers' Questions Apr 10, 2022

Chris Nutt (Belfast) asks the chief investigator of the FIRST-ABC trial Padmanabhan Ramnarayan (London) questions from the viewers during the livestream presentation of the trial results.

FIRST-ABC Trial Results - Editorial Apr 10, 2022

Adrienne Randolph (Boston) delivers an independent editorial on the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.

FIRST-ABC Trial Results Presentation Apr 10, 2022

Dr Padmanabhan Ramnarayan (London) and Mr Alvin Richards-Belle (London) present the results of the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.

COMBAT-COVID Trial Feb 28, 2022

Pär Johansson from Copenhagen joins Rob Mac Sweeney to discuss the fascinating phase II COMBAT-COVID trial, investigating prostacyclin in intubated patients with COVID-19 and severe endotheliopathy. The trial was published in the American Journal of Respiratory and Critical Care Medicine in November 2021.

PLUS Trial Result Follow Up Podcast Feb 22, 2022

Naomi Hammond and Simon Finfer join Rob Mac Sweeney to discuss the reaction of the critical care community to the presentation and publication of both the PLUS trial and the systematic review and meta analysis comparing balanced solutions with 0.9% saline in the critically ill.

BOUGIE Trial Follow Up Podcast Feb 13, 2022

Drs Brian Driver and Matt Prekker join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BOUGIE trial, comparing the use of a stylet with that of a bougie in emergency intubation.

BOUGIE Trial Results - Panel Discussion Dec 09, 2021

Dr Rob Mac Sweeney (Belfast, Northern Ireland) chairs a panel discussion on the results of the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in either the emergency department or the ICU. The panelists are Prof Jonathan Benger (Bristol, England), Dr George Kovacs (Halifax, Canada), Dr Jean-Baptiste (Nantes, France) and Prof Sheila Myatra (Mumbai, India). They are joined by the trialists Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA), Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nashville, USA).

BOUGIE Trial Results - Viewer's Questions Dec 09, 2021

Dr Chris Nutt (Belfast, Northern Ireland) asks questions posed by viewers of the BOUGIE trial results presentation livestream. These are answered by Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA). Prof Jonathan Benger (Bristol, England) also joins the discussion.

BOUGIE Trial Results Editorial Dec 09, 2021

Prof Sheila Myatra (Mumbai, India) delivers an independent editorial on the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU. Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA) reply to the editorial and Prof Jonathan Benger (Bristol, England) also joins the discussion.

BOUGIE Trial Results Presentation Dec 09, 2021

Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA) and Dr Brian Driver (Minneapolis, USA) present the results of the BOUGIE trial at a Critical Care Reviews Trial Results Livestream, on December 8th, 2021. The BOUGIE trial compared the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU.

COCA Trial Panel Discussion Dec 06, 2021

Theresa Olasveengen (Oslo, Norway), Victoria Cornelius (London, England) and Christopher Seymour (Pittsburgh, USA) join trialists Mikael Fink Vallentin and Lars Andersen (Aarhus, Denmark), as well as editorialist Gavin Perkins (Coventry, England), to discuss the COCA trial.

COCA Trial - Viewer's Questions Dec 06, 2021

Dr Chris Nutt asks Dr Mikael Fink Vallentin and Lars Andersen questions form the viewers, during the livestream presentation of the COCA trial results. The COCA trial investigates calcium for out-of-hospital cardiac arrest and was presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.

COCA Trial Results Presentation Dec 06, 2021

Drs Mikael Fink Vallentin and Lars Andersen (University of Aarhus, Denmark) present the results of the COCA trial, investigating calcium for out-of-hospital cardiac arrest. The COCA trial results were presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.

COCA Trial Editorial Dec 06, 2021

Prof Gavin Perkins (University of Warwick) delivers an editorial on the COCA trial, investigating calcium for out-of-hospital cardiac arrest. The COCA trial results were presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.

The HOPE Trial Preliminary Results Oct 26, 2021

Dr Bharath Kumar presents preliminary results of the HOPE trial and discusses the difficulties of undertaking research during a pandemic.

COVID STEROID 2 Trial Results Presentation - Panel Discussion Oct 26, 2021

Bram Rochwerg (Hamilton, Canada), Paul Mouncey (London, England) & Colin McArthur (Auckland, New Zealand) join trialists Sheila Nainan Myatra (Mumbai, India), Bala Ventakesh (Brisbane, Australia) and Anders Perner (Copenhagen, Denmark), as well as editorialists Marion Campbell (Aberdeen, Scotland), to discuss the COVID STEROID 2 trial.

COVID STEROID 2 Trial Results Presentation - Viewer's Questions Oct 26, 2021

Chris Nutt (Belfast) asks investigators Sheila Nainan Myatra, Bala Venkatesh & Anders Perner questions from the viewers during the D STEROID 2 Trial Results Presentation. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on October 21st, 2021

COVID STEROID 2 Trial Editorial Oct 26, 2021

Prof Marion Campbell (Aberdeen, Scotland) delivers an editorial on the COVID STEROID 2 Trial, comparing 12mg with 6mg of dexamethasone in patients with severe COVID-19 and hypoxia, at a Critical Care Reviews Trial Result Livestream, on October 21st, 2021.

COVID STEROID 2 Trial Results Presentation Oct 26, 2021

Sheila Nainan Myatra (Mumbai, India), Bala Ventakesh (Brisbane, Australia), Anders Perner (Copenhagen, Denmark) present the results of the COVID STEROID 2 Trial, comparing 12mg with 6mg of dexamethasone in patients with severe COVID-19 and hypoxia, at a Critical Care Reviews Trial Result Livestream, on October 21st, 2021.

VAM-IHCA Trial Follow-Up Podcast Oct 13, 2021

Chief investigator Lars Andersen joins Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the VAM-IHCA trial results, investigating vasopressin and methylprednisolone for in-hospital cardiac arrest.

VAM-IHCA Trial Results Presentation - Panel Discussion Oct 01, 2021

Rob Mac Sweeney (Belfast) hosts an expert panel to discuss the findings of the VAM-IHCA trial, investigating vasopressin and methylprednisolone for in-hospital cardiac arrest. The panel consists of Katherine Berg (Boston), Bernd Botttiger (Cologne), Ranjit Lall (Coventry), Louise Morrison (Toronto), Spyros Mentzelopoulos (Athens), Lars Wiuff Andersen & Asger Granfeldt (Aarhus), and Spyros Mentzelopoulos (Athens). This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.

VAM-IHCA Trial Results Presentation - Viewer's Questions Oct 01, 2021

Chris Nutt (Belfast) poses questions from the viewers to the lead investigators of the VAM-IHCA trial, Lars Wiuff Andersen and Asger Granfeldt. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.

VAM-IHCA Trial Results Presentation - Editorial Oct 01, 2021

Prof Spyros Mentzelopoulos (Athens, Greece) delivers an independent editorial on the VAM-IHCA trial, investigating vasopressin and methylprednisolone for in-hospital cardiac arrest. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021

VAM-IHCA Trial Results Presentation Oct 01, 2021

Asger Granfeldt & Lars Wiuff Andersen (Aarhus, Denmark) present the results of the VAM-IHCA trial, investigating the combination of vasopressin and methylprednisolone for in-hospital cardiac arrest. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.

Ivermectin Sep 03, 2021

Prof Alistair Nichol (Dublin & Melbourne) discusses why the REMAP-CAP adaptive platform trial has chosen to investigate ivermectin, given the controversy surrounding this agent.

Behind the Scenes Aug 23, 2021

Dr Lennie Derde is the Trial Steering Committee Chair and the European Coordinating Investigator for the REMAP-CAP project. She discusses the running of the REMAP-CAP trial, her background in critical care and infectious diseases, how she got into critical care research, the background of the REMAP-CAP trial and its current workload for her. We also review the output from the trial to date and finish by considering how this pandemic is likely to progress.

BaSICS Livestream Follow-Up Podcast Aug 21, 2021

BaSICS trial leads Drs Fernando Zampieri & Alexandre Biasi Cavalcante join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BaSICS trial results.

TTM2 Livestream Follow-Up Podcast Aug 18, 2021

Niklas Nielsen, the chief investigator for the TTM2 trial, joins Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the TTM2 trial results.

Interleukin-6 Antagonists in COVID-19 Meta Analysis Jul 06, 2021

Prof Manu Shankar-Hari, the lead for the WHO REACT group's prospective meta analysis on interleukin 6 antagonism in patients hospitalised with COVID-19, joins Rob Mac Sweeney to discuss this important work

SYNAPSE-ICU Study Jun 29, 2021

Prof Giuseppe Citerio (Milan) joins Rob Mac Sweeney to discuss the global SYNAPSE-ICU study, investigating the use of intracranial pressure monitoring in acute brain injury.

TTM2 Results Viewers' Questions Jun 24, 2021

Phil Gillen (Belfast) asks questions posed by the viewers of the TTM2 results livestream to the TTM2 trialists Niklas Nielsen, Josef Dankiewicz and Gisela Lilja.

TTM2 Results Presentation Jun 24, 2021

Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund) presents the results of the landmark TTM2 trial, comparing hypothermia (33°) with normothermia (<37.8°) in 1850 comatose survivors of out-of-hospital cardiac arrest.

TTM2 Results Panel Discussion Jun 24, 2021

Panellists Jerry Nolan, Kathy Rowan and Terri Hough join editorialist Stephen Bernard and TTM2 investigators Niklas Nielsen, Josef Dankiewicz and Gisela Lilja to discuss the landmark TTM2 trial at the Critical Care Reviews hosted TTM2 results livestream.

TTM2 Results Editorial Jun 23, 2021

Prof Stephen Bernard (Melbourne) delivers an editorial on the TTM2 trial result, delivered as part of the Critical Care Reviews hosted TTM2 Trial Results Livestream.

Learning while Doing Jun 05, 2021

Prof Derek Angus, from Pittsburgh, USA, discusses a modern healthcare system which merges research into clinical practice, producing a "learning while doing" healthcare model.

COAST Trial May 23, 2021

Professor Kath Maitland joins Rob Mac Sweeney to discuss the COAST trial, investigating oxygen therapy in African children with severe pneumonia.

The Ventilator May 11, 2021

In the latest episode on the REMAP-CAP series, Prof Alistair Nichol (Dublin / Melbourne) discuss the upcoming ventilation domain with Rob Mac Sweeney.

INTUBE Study Mar 28, 2021

Professors Vincenzo Russotto and Sheila Myatra join Rob Mac Sweeney to discuss their INTUBE study, investigating tracheal intubation practices in the critically ill around the world.

Mathias Pletz - The Pandemic Dec 27, 2020

Mathias Pletz discusses pandemics and the role of REMAP-CAP adaptive platform trial in responding to the COVID-19 pandemic

Marshall & Murthy - The Interventions Dec 27, 2020

John Marshall and Srinivas Murthy discuss the choice of interventions in the REMAP-CAP adaptive platform trial

Scott Berry - The Complexity Dec 23, 2020

Scott Berry discusses the methodological and statistical framework behind the REMAP-CAP trial

Steve Webb - The Beginning Dec 21, 2020

Prof Steve Webb, from Perth, Australia, discusses the origin, design and execution of the REMAP-CAP adaptive platform trial

REMAP-CAP Steroid Domain Results Podcast Sep 01, 2020

Prof Derek Angus and Prof Anthony Gordon, senior investigators for the REMAP-CAP trial, discuss the COVID-19 steroid domain results of the REMAP-CAP trial on the Critical Care Reviews Podcast

The COACT Trial Aug 21, 2020

Prof Jorrit Lemkes (Amsterdam, The Netherlands) presents the COACT Trial, investigating the timing of coronary angiography in patients with cardiac arrest without ST elevation. This is followed by an editorial by Dr Chris Nickson (Melbourne, Australia). This talk was given at the Critical Care Reviews Meeting 2020, in Titanic Belfast.

MEGA-ROX Aug 10, 2020

Dr Paul Young describes MEGA-ROX, a registry-based, adaptive platform trial investigating oxygenation targets in the critically ill. This is followed by a panel discussion involving trialists, methodologists and statisticians on this ambitious trial design.

ICU-ROX Trial Aug 07, 2020

Dr Paul Young (Wellington, New Zealand) presents the ICU-ROX trial, investigating conservative oxygen therapy in mechanically ventilated patients in the ICU, at the Critical Care Reviews Meeting 2020, in Titanic Belfast. Prof Anders Perner (Copenhagen, Denmark) gives an editorial on this trial afterwards.

John Hinds Lecture 2020 Aug 07, 2020

Prof Kathryn Maitland delivers the honorary John Hinds Lecture, entitled "A Higher Calling: two decades of emergency research in Africa", at the Critical Care Reviews Meeting 2020, at Titanic Belfast.

The TRACT Trial Aug 07, 2020

Prof Kathryn Maitland discusses the TRACT trial, investigating red blood cell transfusion in African children with anaemia, at the Critical Care Reviews Meeting 2020, at Titanic Belfast.

John Hinds Trauma Lecture 2019 Nov 08, 2019

Prof Maureen McCunn delivers the annual honorary John Hinds Trauma Lecture at the Critical Care Reviews Meeting 2019, in Titanic, Belfast, entitled "A Culture of Excellence - The R Adams Cowley Shock Trauma Center"

PreVENT Editorial Nov 03, 2019

Dr Lennie Derde delivers an editorial on the PreVENT trial, comparing low with intermediate tidal volumes in critically ill patients without ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

PreVENT Nov 03, 2019

Prof Marcus Schultz presents the PreVENT trial, comparing low with intermediate tidal volumes in critically ill patients without ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

PAMPer Editorial Sep 25, 2019

Prof Maureen McCunn delivers an editorial on the PAMPer trial, investigating plasma in prehospital trauma, at the Critical Care Reviews Meeting 2019, at Titanic, Belfast.

PAMPer Sep 25, 2019

Prof Jason Sperry presents the PAMPer trial, investigating plasma in prehospital trauma, at the Critical Care Reviews Meeting 2019, at Titanic, Belfast.

EOLIA Editorial Sep 23, 2019

Prof Marion Campbell delivers an editorial on the EOLIA trial, investigating ECMO in severe ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

EOLIA Sep 23, 2019

Prof Niall Ferguson presents the EOLIA trial, investigating ECMO in severe ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

TARGET Editorial Sep 18, 2019

Prof Todd Rice gives an editorial on the TARGET trial, comparing energy-dense (1.5 kcal/ml) with routine (1.0 kcal/ml) enteral nutrition in critically ill patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

TARGET Sep 18, 2019

Prof Marianne Chapman presents the TARGET trial, comparing energy-dense (1.5 kcal/ml) with routine (1.0 kcal/ml) enteral nutrition in critically ill patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

SUP-ICU Editorial Sep 14, 2019

Prof Marianne Chapman delivers an editorial on the SUP-ICU trial, investigating pantoprazole stress ulcer prophylaxis in critically ill mechanically ventilated patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

SUP-ICU Sep 14, 2019

Dr Morten Hylander Møller presents the SUP-ICU trial, investigating pantoprazole stress ulcer prophylaxis in critically ill, mechanically ventilated patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

SMART-Editorial Sep 11, 2019

Prof Anders Perner delivers an editorial on the SMART trial, comparing saline with balanced crystalloids in ICU patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

SMART Sep 11, 2019

Prof Todd Rice discusses the SMART trial, comparing saline with balanced crystalloids in ICU patients, at the Critical Care Reviews Meeting 2019

CCR19 Day 1 Trials Panel Discussion Sep 07, 2019

Prof Danny McAuley chairs a panel discussion between the investigators of the trials presented in detail at day 1 of the Critical Care Reviews Meeting 2019 - POPPI (Prof Kathy Rowan), MIND-USA (Assoc Prof Timoth Girard), AI in Sepsis (Prof Anthony Gordon), ANDROMEDA-SHOCK (Prof Jan Bakker), SMART (Prof Todd Rice) and APPROCCHSS (Prof Djillali Annane)

ANDROMEDA-SHOCK Editorial Sep 04, 2019

Dr Manu Shankar-Hari delivers an editorial on the ANDROMEDA-SHOCK trial, comparing peripheral perfusion-guided with serum lactate-guided resuscitation in septic shock

ANDROMEDA-SHOCK Sep 04, 2019

Prof Jan Bakker presents the ANDROMEDA-SHOCK trial, comparing peripheral perfusion-guided with serum lactate-guided resuscitation in septic shock

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