Brain Matters (Audio)

Latest Episodes:

Using Human Stem Cells to Probe Mechanisms of Neuronal Changes in Alzheimer’s Disease - Larry Goldstein Oct 10, 2020

Show notes

Lawrence S.B. Goldstein, PhD discusses his career in science and his work to understand the molecular basis of neuronal defects in Alzheimer's Disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36338]

Stem Cells and Disease Modeling in a Dish Autism Research via Brain Organoids Aug 28, 2020

Show notes

Researcher Alysson Muotri is using stem cells to study everything from autism to the Zika virus. In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. Series: "Health Matters" [Health and Medicine] [Show ID: 36301]

Little-Known Jobs of the Immune System (They Are a Big Deal) Jul 31, 2020

Show notes

Interactive immune systems are at the center of cancer and other diseases. Dr. Matthew Krummel explores some lesser-known functions of the immune system related to memory making, arteriosclerosis, and gut health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 36205]

Is Cognitive Decline Inevitable? Jul 11, 2020

Show notes

Dr. Aimee Kao discusses key behaviors known to protect brain health. Dr. Kao looks at population trends and wonders if they tell a complete story. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 36154]

Staying Sharp: Current and Future Approaches to Brain Health and Alzheimer’s Therapeutics Dec 07, 2019

Show notes

Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35238]

APOE TREM and Microglia in the Pathogenesis of Tau-mediated Neurodegeneration with David Holtzman MD - Shiley Endowed Lecture Oct 08, 2019

Show notes

David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of Aβ and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 35262]

The Burden of Alzheimer’s Disease and Related Diseases in Vulnerable Populations Aug 30, 2019

Show notes

Worldwide 50 million people live with dementia. By 2040 over 70% of them will be living in the developing world. Dr. Shamiel McFarlane explores the social and economic cost of dementia around the world. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34779]

Brain Health Promotion Strategies: Separating Reality-Based Hope From Hopeless Pseudo-Medicine Aug 27, 2019

Show notes

There are modifiable behaviors that may reduce the risk factor of Alzheimer's: vascular disease, sedentary lifestyle, depression/stress, diet factors and alcohol. Kaitlin Casaletto talks about the benefits of an active lifestyle and proper nutrition. Then Dr. Joanna Hellmuth looks at how to decode direct-to-consumer interventions - dietary supplements - and the rise of pseudo-medicine for dementia. She explains that supplements may or may not be safe and that manufacturers can make broad claims without supporting evidence. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35136]

Treatment and Management of Patients with Neurodegenerative Disease: Current State of Science Aug 16, 2019

Show notes

Dr. Julio Rojas-Martinez discusses the pharmacological treatment of Alzheimer’s disease now and what is in development. Current approaches pursue early intervention in the dementia phase. Novel emerging strategies will likely accompany anti-amyloid and anti-tau approaches in the future. Then Sarah Dulaney, RN, describe dementia education, support, and non-pharmacological treatment strategies. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34777]

Looking Beyond Alzheimer’s Disease: An Overview of Other Major Forms of Neurodegenerative Disease Aug 05, 2019

Show notes

Alzheimer’s disease is the most common but not the only cause of dementia throughout the lifespan. Dr.Salvatore Spina discusses frontotemporal dementias and how they differ. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34776]

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